locus-tag	class	description
XCAW_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XCAW_00005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XCAW_00006	COG0187	DNA topoisomerase II activity
XCAW_00008	COG0501	Belongs to the peptidase M48B family
XCAW_00014	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XCAW_00016	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCAW_00026	COG0793	Belongs to the peptidase S41A family
XCAW_00027	COG4942	peptidase
XCAW_00029	COG2234	aminopeptidase activity
XCAW_00031	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCAW_00032	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCAW_00040	COG2211	Major facilitator Superfamily
XCAW_00043	COG3693	PFAM glycoside hydrolase, family 10
XCAW_00045	COG3693	PFAM glycoside hydrolase, family 10
XCAW_00046	COG1904	glucuronate isomerase
XCAW_00047	COG3250	beta-galactosidase activity
XCAW_00049	COG3386	PFAM SMP-30 Gluconolaconase
XCAW_00054	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XCAW_00063	COG0246	Mannitol dehydrogenase
XCAW_00064	COG1472	Belongs to the glycosyl hydrolase 3 family
XCAW_00066	COG4948	Mandelate Racemase Muconate Lactonizing
XCAW_00068	COG3661	Belongs to the glycosyl hydrolase 67 family
XCAW_00070	COG2115	Belongs to the xylose isomerase family
XCAW_00071	COG0037	tRNA processing
XCAW_00072	COG2974	May be involved in recombination
XCAW_00075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XCAW_00077	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XCAW_00078	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XCAW_00079	COG0805	protein transport
XCAW_00081	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XCAW_00081	COG0519	Catalyzes the synthesis of GMP from XMP
XCAW_00083	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XCAW_00084	COG0752	glycyl-tRNA synthetase alpha subunit
XCAW_00090	COG0729	surface antigen
XCAW_00091	COG2911	Protein conserved in bacteria
XCAW_00095	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCAW_00097	COG3265	gluconokinase activity
XCAW_00098	COG2211	Major facilitator Superfamily
XCAW_00099	COG3459	Glycosyltransferase 36 associated
XCAW_00102	COG2205	protein histidine kinase activity
XCAW_00103	COG1971	Probably functions as a manganese efflux pump
XCAW_00104	COG1414	Transcriptional regulator
XCAW_00105	COG0738	Major facilitator superfamily
XCAW_00106	COG3254	rhamnose metabolic process
XCAW_00107	COG4948	Mandelate Racemase Muconate Lactonizing
XCAW_00108	COG0179	Fumarylacetoacetate (FAA) hydrolase
XCAW_00109	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_00112	COG3507	Belongs to the glycosyl hydrolase 43 family
XCAW_00118	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XCAW_00120	COG3162	membrane
XCAW_00121	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XCAW_00123	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XCAW_00125	COG1940	carbohydrate kinase activity
XCAW_00125	COG1846	Transcriptional regulator
XCAW_00126	COG0708	Exodeoxyribonuclease III
XCAW_00129	COG2091	lysine biosynthetic process via aminoadipic acid
XCAW_00131	COG3540	Alkaline phosphatase
XCAW_00132	COG0357	Ribosomal RNA small subunit methyltransferase G
XCAW_00136	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCAW_00139	COG0227	Belongs to the bacterial ribosomal protein bL28 family
XCAW_00140	COG0267	Belongs to the bacterial ribosomal protein bL33 family
XCAW_00141	COG2159	amidohydrolase
XCAW_00143	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XCAW_00144	COG0583	DNA-binding transcription factor activity
XCAW_00145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCAW_00148	COG0210	DNA helicase
XCAW_00175	COG3501	Rhs element vgr protein
XCAW_00182	COG0631	protein serine/threonine phosphatase activity
XCAW_00183	COG0515	serine threonine protein kinase
XCAW_00183	COG2815	serine threonine protein kinase
XCAW_00191	COG0408	coproporphyrinogen oxidase activity
XCAW_00194	COG1506	peptidase
XCAW_00194	COG0823	Involved in the tonB-independent uptake of proteins
XCAW_00194	COG4946	Tricorn protease homolog
XCAW_00199	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XCAW_00202	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XCAW_00209	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_00212	COG0463	Glycosyl transferase, family 2
XCAW_00214	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XCAW_00215	COG3100	YcgL domain-containing protein
XCAW_00218	COG3387	PFAM Glycoside hydrolase 15-related
XCAW_00219	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XCAW_00221	COG3338	carbonate dehydratase activity
XCAW_00223	COG2239	Acts as a magnesium transporter
XCAW_00224	COG1042	CoA-binding domain protein
XCAW_00224	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XCAW_00224	COG0045	succinate-CoA ligase (ADP-forming) activity
XCAW_00227	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XCAW_00228	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XCAW_00234	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XCAW_00235	COG0842	Transport permease protein
XCAW_00236	COG1131	(ABC) transporter
XCAW_00237	COG0633	Ferredoxin
XCAW_00237	COG0543	2 iron, 2 sulfur cluster binding
XCAW_00246	COG1476	TRANSCRIPTIONal
XCAW_00248	COG4555	ABC transporter
XCAW_00255	COG0625	glutathione transferase activity
XCAW_00267	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XCAW_00270	COG1199	ATP-dependent helicase activity
XCAW_00275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XCAW_00277	COG0745	RESPONSE REGULATOR receiver
XCAW_00278	COG2205	protein histidine kinase activity
XCAW_00284	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XCAW_00287	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XCAW_00296	COG3237	CsbD-like
XCAW_00297	COG0180	Tryptophanyl-tRNA synthetase
XCAW_00298	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCAW_00301	COG0697	spore germination
XCAW_00306	COG1136	(ABC) transporter
XCAW_00307	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCAW_00308	COG4585	Histidine kinase
XCAW_00309	COG2197	response regulator
XCAW_00312	COG0753	catalase activity
XCAW_00315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XCAW_00316	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XCAW_00321	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XCAW_00327	COG0642	Histidine kinase
XCAW_00328	COG0745	RESPONSE REGULATOR receiver
XCAW_00329	COG1090	epimerase
XCAW_00337	COG1690	Belongs to the RtcB family
XCAW_00343	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XCAW_00346	COG0606	chelatase, subunit chli
XCAW_00354	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XCAW_00355	COG1166	arginine decarboxylase activity
XCAW_00356	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XCAW_00359	COG2755	lipolytic protein G-D-S-L family
XCAW_00359	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XCAW_00360	COG4221	oxidoreductase activity
XCAW_00363	COG0018	arginyl-trna synthetase
XCAW_00364	COG2003	Belongs to the UPF0758 family
XCAW_00365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XCAW_00366	COG0756	dUTP diphosphatase activity
XCAW_00370	COG0463	Glycosyl transferase, family 2
XCAW_00373	COG1475	DNA binding
XCAW_00374	COG1192	Involved in chromosome partitioning
XCAW_00376	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XCAW_00377	COG0708	Exodeoxyribonuclease III
XCAW_00378	COG2223	nitrite transmembrane transporter activity
XCAW_00380	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XCAW_00381	COG0739	heme binding
XCAW_00382	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XCAW_00388	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XCAW_00390	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XCAW_00392	COG1435	thymidine kinase activity
XCAW_00393	COG0210	DNA helicase
XCAW_00396	COG3132	Protein of unknown function, DUF480
XCAW_00397	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XCAW_00398	COG0284	orotidine-5'-phosphate decarboxylase activity
XCAW_00404	COG2937	Belongs to the GPAT DAPAT family
XCAW_00414	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCAW_00415	COG1064	alcohol dehydrogenase
XCAW_00416	COG0493	'glutamate synthase
XCAW_00417	COG0067	glutamate synthase
XCAW_00417	COG0069	glutamate synthase activity
XCAW_00417	COG0070	glutamate synthase
XCAW_00421	COG2366	antibiotic biosynthetic process
XCAW_00428	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
XCAW_00431	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XCAW_00432	COG0297	glycogen (starch) synthase activity
XCAW_00432	COG0438	transferase activity, transferring glycosyl groups
XCAW_00438	COG0367	asparagine synthase
XCAW_00444	COG1132	(ABC) transporter
XCAW_00467	COG1111	helicase
XCAW_00467	COG1205	dead DEAH box helicase
XCAW_00468	COG1272	protein, Hemolysin III
XCAW_00470	COG0300	oxidoreductase activity
XCAW_00471	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_00476	COG2249	NAD(P)H dehydrogenase (quinone) activity
XCAW_00478	COG2963	transposase activity
XCAW_00489	COG3237	CsbD-like
XCAW_00498	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XCAW_00499	COG0477	Major facilitator Superfamily
XCAW_00507	COG0714	Associated with various cellular activities
XCAW_00513	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XCAW_00515	COG4772	TonB-dependent receptor
XCAW_00517	COG0662	Cupin 2, conserved barrel domain protein
XCAW_00518	COG1012	belongs to the aldehyde dehydrogenase family
XCAW_00523	COG1304	FMN binding
XCAW_00525	COG4585	Histidine kinase
XCAW_00526	COG2197	response regulator
XCAW_00530	COG3710	Transcriptional regulator
XCAW_00531	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XCAW_00546	COG2963	transposase activity
XCAW_00547	COG2801	Transposase and inactivated derivatives
XCAW_00548	COG0366	Alpha amylase catalytic
XCAW_00549	COG0366	Alpha amylase catalytic
XCAW_00550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XCAW_00554	COG0657	acetylesterase activity
XCAW_00554	COG2755	lipolytic protein G-D-S-L family
XCAW_00556	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XCAW_00559	COG3507	Belongs to the glycosyl hydrolase 43 family
XCAW_00560	COG1609	Transcriptional regulator
XCAW_00562	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XCAW_00563	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_00565	COG2755	lipolytic protein G-D-S-L family
XCAW_00569	COG3186	Phenylalanine-4-hydroxylase
XCAW_00570	COG1522	sequence-specific DNA binding
XCAW_00573	COG1752	Esterase of the alpha-beta hydrolase superfamily
XCAW_00575	COG1119	ATPase activity
XCAW_00578	COG1125	glycine betaine transport
XCAW_00581	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XCAW_00584	COG1396	sequence-specific DNA binding
XCAW_00588	COG0489	protein tyrosine kinase activity
XCAW_00589	COG2062	phosphohistidine phosphatase, SixA
XCAW_00591	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCAW_00600	COG1968	undecaprenyl-diphosphatase activity
XCAW_00601	COG0174	glutamine synthetase
XCAW_00602	COG0347	Belongs to the P(II) protein family
XCAW_00603	COG0004	ammonium transporteR
XCAW_00604	COG3852	Histidine kinase
XCAW_00605	COG2204	response regulator
XCAW_00606	COG2032	superoxide dismutase activity
XCAW_00607	COG2032	superoxide dismutase activity
XCAW_00610	COG0183	Belongs to the thiolase family
XCAW_00617	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XCAW_00618	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XCAW_00619	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XCAW_00621	COG0028	Belongs to the TPP enzyme family
XCAW_00622	COG2205	protein histidine kinase activity
XCAW_00627	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XCAW_00631	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCAW_00633	COG0596	Alpha beta hydrolase
XCAW_00635	COG0318	PFAM AMP-dependent synthetase and ligase
XCAW_00636	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XCAW_00638	COG1181	Belongs to the D-alanine--D-alanine ligase family
XCAW_00640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XCAW_00642	COG0564	pseudouridine synthase activity
XCAW_00648	COG0339	signal peptide processing
XCAW_00653	COG0475	glutathione-regulated potassium exporter activity
XCAW_00654	COG0583	DNA-binding transcription factor activity
XCAW_00655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XCAW_00656	COG2224	Isocitrate lyase
XCAW_00658	COG3706	GGDEF domain
XCAW_00664	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XCAW_00665	COG1960	acyl-CoA dehydrogenase activity
XCAW_00676	COG0523	cobalamin synthesis protein
XCAW_00678	COG0697	spore germination
XCAW_00680	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XCAW_00681	COG1846	Transcriptional regulator
XCAW_00682	COG1764	response to oxidative stress
XCAW_00687	COG2130	NADP-dependent
XCAW_00690	COG1187	pseudouridine synthase activity
XCAW_00693	COG1643	Atp-dependent helicase
XCAW_00694	COG4807	Protein conserved in bacteria
XCAW_00695	COG2351	hydroxyisourate hydrolase activity
XCAW_00696	COG2072	flavoprotein involved in K transport
XCAW_00700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XCAW_00709	COG1957	nucleoside hydrolase
XCAW_00711	COG2252	PERMEase
XCAW_00716	COG0084	hydrolase, TatD family'
XCAW_00719	COG0583	DNA-binding transcription factor activity
XCAW_00720	COG2814	Major facilitator Superfamily
XCAW_00722	COG2267	carboxylic ester hydrolase activity
XCAW_00723	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XCAW_00724	COG1902	pentaerythritol trinitrate reductase activity
XCAW_00728	COG0745	RESPONSE REGULATOR receiver
XCAW_00729	COG2205	protein histidine kinase activity
XCAW_00730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCAW_00732	COG1538	Outer membrane efflux protein
XCAW_00735	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XCAW_00736	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XCAW_00737	COG0583	DNA-binding transcription factor activity
XCAW_00743	COG0702	epimerase
XCAW_00744	COG1733	regulation of RNA biosynthetic process
XCAW_00748	COG2801	Transposase and inactivated derivatives
XCAW_00749	COG2963	transposase activity
XCAW_00751	COG0129	dihydroxy-acid dehydratase activity
XCAW_00754	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XCAW_00765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XCAW_00766	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XCAW_00771	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XCAW_00772	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XCAW_00774	COG3485	protocatechuate 3,4-dioxygenase
XCAW_00775	COG3485	protocatechuate 3,4-dioxygenase
XCAW_00777	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XCAW_00778	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XCAW_00780	COG1414	Transcriptional regulator
XCAW_00784	COG0445	tRNA wobble uridine modification
XCAW_00792	COG2267	carboxylic ester hydrolase activity
XCAW_00794	COG0156	8-amino-7-oxononanoate synthase activity
XCAW_00795	COG1040	competence protein
XCAW_00796	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XCAW_00797	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XCAW_00816	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XCAW_00831	COG3264	Mechanosensitive ion channel
XCAW_00831	COG1511	domain protein
XCAW_00832	COG1368	sulfuric ester hydrolase activity
XCAW_00834	COG2354	Protein conserved in bacteria
XCAW_00835	COG3706	GGDEF domain
XCAW_00835	COG0745	RESPONSE REGULATOR receiver
XCAW_00836	COG0297	glycogen (starch) synthase activity
XCAW_00837	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XCAW_00838	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XCAW_00843	COG0702	epimerase
XCAW_00844	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_00850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCAW_00851	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_00853	COG0513	Belongs to the DEAD box helicase family
XCAW_00857	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XCAW_00859	COG3483	tryptophan 2,3-dioxygenase activity
XCAW_00860	COG3104	oligopeptide transport
XCAW_00864	COG2852	Protein conserved in bacteria
XCAW_00865	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XCAW_00868	COG1320	monovalent cation:proton antiporter activity
XCAW_00869	COG2212	antiporter activity
XCAW_00871	COG0651	ATP synthesis coupled electron transport
XCAW_00872	COG1006	Multisubunit Na H antiporter MnhC subunit
XCAW_00873	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XCAW_00873	COG2111	Na H antiporter
XCAW_00877	COG3179	chitinase
XCAW_00881	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XCAW_00882	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XCAW_00886	COG1597	lipid kinase activity
XCAW_00892	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XCAW_00893	COG0134	indole-3-glycerol-phosphate synthase activity
XCAW_00895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XCAW_00896	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XCAW_00898	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XCAW_00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XCAW_00901	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XCAW_00904	COG1051	belongs to the nudix hydrolase family
XCAW_00912	COG0316	Belongs to the HesB IscA family
XCAW_00916	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XCAW_00919	COG2814	Major facilitator Superfamily
XCAW_00920	COG0583	DNA-binding transcription factor activity
XCAW_00921	COG2814	Major facilitator Superfamily
XCAW_00922	COG1289	transmembrane transporter activity
XCAW_00923	COG0151	Belongs to the GarS family
XCAW_00925	COG0138	bifunctional purine biosynthesis protein purh
XCAW_00926	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XCAW_00927	COG2267	carboxylic ester hydrolase activity
XCAW_00928	COG2453	phosphatase
XCAW_00928	COG0671	phosphoesterase, PA-phosphatase related
XCAW_00933	COG4589	Belongs to the CDS family
XCAW_00934	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XCAW_00938	COG2264	protein methyltransferase activity
XCAW_00942	COG0439	Biotin carboxylase
XCAW_00944	COG0511	ligase activity, forming carbon-carbon bonds
XCAW_00945	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XCAW_00947	COG1324	tolerance protein
XCAW_00952	COG0300	oxidoreductase activity
XCAW_00953	COG2356	endonuclease I
XCAW_00954	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
XCAW_00955	COG0459	protein refolding
XCAW_00958	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XCAW_00961	COG3386	PFAM SMP-30 Gluconolaconase
XCAW_00963	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XCAW_00964	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XCAW_00968	COG0778	Nitroreductase
XCAW_00969	COG2353	YceI-like domain
XCAW_00975	COG3052	prosthetic group binding
XCAW_00979	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
XCAW_00980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XCAW_00982	COG1802	Transcriptional regulator
XCAW_00992	COG2801	Transposase and inactivated derivatives
XCAW_00993	COG2963	transposase activity
XCAW_00994	COG4221	oxidoreductase activity
XCAW_00997	COG4221	oxidoreductase activity
XCAW_00999	COG0435	Glutathione S-transferase
XCAW_01005	COG2963	transposase activity
XCAW_01008	COG0308	aminopeptidase N
XCAW_01010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XCAW_01013	COG4948	Mandelate Racemase Muconate Lactonizing
XCAW_01014	COG3250	beta-galactosidase activity
XCAW_01018	COG1970	mechanosensitive ion channel activity
XCAW_01022	COG3273	potassium ion transport
XCAW_01022	COG0471	metal ion transport
XCAW_01023	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XCAW_01024	COG2022	thiamine diphosphate biosynthetic process
XCAW_01032	COG3209	COG3209 Rhs family protein
XCAW_01038	COG3657	addiction module killer protein
XCAW_01049	COG2003	Belongs to the UPF0758 family
XCAW_01050	COG3692	DNA binding
XCAW_01057	COG2189	Belongs to the N(4) N(6)-methyltransferase family
XCAW_01078	COG0745	RESPONSE REGULATOR receiver
XCAW_01079	COG5002	protein histidine kinase activity
XCAW_01080	COG2801	Transposase and inactivated derivatives
XCAW_01081	COG2963	transposase activity
XCAW_01085	COG0237	dephospho-CoA kinase activity
XCAW_01086	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XCAW_01093	COG0045	succinate-CoA ligase (ADP-forming) activity
XCAW_01094	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XCAW_01099	COG2369	cell adhesion
XCAW_01113	COG2963	transposase activity
XCAW_01114	COG2801	Transposase and inactivated derivatives
XCAW_01149	COG4191	Histidine kinase
XCAW_01149	COG0784	Response regulator, receiver
XCAW_01150	COG0745	RESPONSE REGULATOR receiver
XCAW_01163	COG4695	Portal protein
XCAW_01169	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XCAW_01171	COG2201	protein-glutamate methylesterase activity
XCAW_01172	COG3852	Histidine kinase
XCAW_01174	COG0544	peptidyl-prolyl cis-trans isomerase activity
XCAW_01175	COG0740	serine-type endopeptidase activity
XCAW_01177	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XCAW_01183	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XCAW_01185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCAW_01187	COG0328	RNA-DNA hybrid ribonuclease activity
XCAW_01188	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XCAW_01189	COG0631	protein serine/threonine phosphatase activity
XCAW_01192	COG0859	PFAM glycosyl transferase family 9
XCAW_01193	COG3642	lipopolysaccharide core region biosynthetic process
XCAW_01194	COG1234	tRNA 3'-trailer cleavage
XCAW_01195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XCAW_01196	COG0315	cyclic pyranopterin monophosphate synthase activity
XCAW_01197	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XCAW_01198	COG0314	molybdopterin synthase activity
XCAW_01200	COG2963	transposase activity
XCAW_01201	COG2801	Transposase and inactivated derivatives
XCAW_01209	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XCAW_01210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XCAW_01211	COG0537	adenosine 5'-monophosphoramidase activity
XCAW_01215	COG0714	Associated with various cellular activities
XCAW_01220	COG0424	maF-like protein
XCAW_01221	COG1399	metal-binding, possibly nucleic acid-binding protein
XCAW_01222	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XCAW_01223	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCAW_01227	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_01228	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XCAW_01230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XCAW_01231	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XCAW_01236	COG3829	transcription factor binding
XCAW_01240	COG3609	addiction module antidote protein, CC2985 family
XCAW_01245	COG2373	Large extracellular alpha-helical protein
XCAW_01249	COG4953	penicillin-binding protein 1C
XCAW_01251	COG0678	peroxiredoxin activity
XCAW_01255	COG0330	HflC and HflK could
XCAW_01256	COG0330	HflC and HflK could
XCAW_01258	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XCAW_01259	COG0308	aminopeptidase N
XCAW_01260	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_01261	COG1309	transcriptional regulator
XCAW_01270	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XCAW_01275	COG0328	RNA-DNA hybrid ribonuclease activity
XCAW_01275	COG0406	alpha-ribazole phosphatase activity
XCAW_01276	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XCAW_01278	COG3387	PFAM Glycoside hydrolase 15-related
XCAW_01279	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_01280	COG3537	Alpha-1,2-mannosidase
XCAW_01283	COG0492	ferredoxin-NADP+ reductase activity
XCAW_01288	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XCAW_01289	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XCAW_01290	COG2080	2 iron, 2 sulfur cluster binding
XCAW_01297	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XCAW_01300	COG0587	DNA-directed DNA polymerase activity
XCAW_01304	COG1297	OPT oligopeptide transporter protein
XCAW_01306	COG1506	peptidase
XCAW_01306	COG0823	Involved in the tonB-independent uptake of proteins
XCAW_01309	COG1917	Cupin 2, conserved barrel domain protein
XCAW_01309	COG2207	Transcriptional regulator
XCAW_01314	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XCAW_01316	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XCAW_01317	COG0745	RESPONSE REGULATOR receiver
XCAW_01318	COG2205	protein histidine kinase activity
XCAW_01320	COG4452	Inner membrane protein CreD
XCAW_01325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XCAW_01326	COG0735	belongs to the Fur family
XCAW_01329	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCAW_01330	COG1538	Outer membrane efflux protein
XCAW_01331	COG1309	transcriptional regulator
XCAW_01333	COG2207	Transcriptional regulator
XCAW_01335	COG0583	DNA-binding transcription factor activity
XCAW_01336	COG2814	Major facilitator Superfamily
XCAW_01337	COG0667	Aldo Keto reductase
XCAW_01361	COG5001	Diguanylate cyclase
XCAW_01361	COG5002	protein histidine kinase activity
XCAW_01362	COG1187	pseudouridine synthase activity
XCAW_01363	COG0745	RESPONSE REGULATOR receiver
XCAW_01363	COG3706	GGDEF domain
XCAW_01366	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XCAW_01367	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
XCAW_01368	COG0475	glutathione-regulated potassium exporter activity
XCAW_01369	COG5002	protein histidine kinase activity
XCAW_01369	COG5000	phosphorelay sensor kinase activity
XCAW_01370	COG0745	RESPONSE REGULATOR receiver
XCAW_01371	COG1538	Outer membrane efflux protein
XCAW_01376	COG1132	(ABC) transporter
XCAW_01384	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XCAW_01385	COG2155	Conserved Protein
XCAW_01391	COG3118	belongs to the thioredoxin family
XCAW_01393	COG0495	leucyl-tRNA aminoacylation
XCAW_01396	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XCAW_01399	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XCAW_01401	COG2968	Membrane
XCAW_01402	COG0424	maF-like protein
XCAW_01403	COG1530	ribonuclease E activity
XCAW_01404	COG3164	Protein of unknown function
XCAW_01406	COG0312	modulator of DNA gyrase
XCAW_01407	COG3028	Belongs to the UPF0307 family
XCAW_01408	COG0312	modulator of DNA gyrase
XCAW_01410	COG4104	PAAR repeat-containing protein
XCAW_01411	COG0142	geranyltranstransferase activity
XCAW_01412	COG1722	exodeoxyribonuclease VII activity
XCAW_01413	COG0037	tRNA processing
XCAW_01414	COG1785	Belongs to the alkaline phosphatase family
XCAW_01415	COG1301	dicarboxylic acid transport
XCAW_01416	COG4106	trans-aconitate 2-methyltransferase activity
XCAW_01418	COG0791	NLP P60 protein
XCAW_01419	COG0791	NLP P60 protein
XCAW_01420	COG1047	Peptidyl-prolyl cis-trans
XCAW_01421	COG2311	Membrane
XCAW_01422	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCAW_01423	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XCAW_01427	COG3590	peptidase
XCAW_01428	COG3590	peptidase
XCAW_01432	COG0489	protein tyrosine kinase activity
XCAW_01433	COG0717	Belongs to the dCTP deaminase family
XCAW_01438	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XCAW_01439	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XCAW_01442	COG0494	nUDIX hydrolase
XCAW_01443	COG0433	COG0433 Predicted ATPase
XCAW_01445	COG0688	phosphatidylethanolamine metabolic process
XCAW_01447	COG2890	protein-(glutamine-N5) methyltransferase activity
XCAW_01448	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XCAW_01449	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XCAW_01450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XCAW_01454	COG0101	tRNA pseudouridine synthase activity
XCAW_01455	COG0135	phosphoribosylanthranilate isomerase activity
XCAW_01457	COG0133	tryptophan synthase activity
XCAW_01459	COG0159	tryptophan synthase activity
XCAW_01460	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XCAW_01461	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XCAW_01469	COG0300	oxidoreductase activity
XCAW_01470	COG0149	triose-phosphate isomerase activity
XCAW_01473	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCAW_01474	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCAW_01475	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCAW_01476	COG0649	NAD binding
XCAW_01477	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XCAW_01478	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XCAW_01480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XCAW_01481	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XCAW_01483	COG0713	ATP synthesis coupled electron transport
XCAW_01486	COG1007	ATP synthesis coupled electron transport
XCAW_01488	COG0779	Required for maturation of 30S ribosomal subunits
XCAW_01489	COG0195	Participates in both transcription termination and antitermination
XCAW_01490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XCAW_01491	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XCAW_01492	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XCAW_01493	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XCAW_01494	COG1185	polyribonucleotide nucleotidyltransferase activity
XCAW_01500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XCAW_01501	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XCAW_01503	COG2095	MarC family integral membrane protein
XCAW_01505	COG1611	Belongs to the LOG family
XCAW_01506	COG3275	phosphorelay sensor kinase activity
XCAW_01514	COG2963	transposase activity
XCAW_01515	COG2801	Transposase and inactivated derivatives
XCAW_01521	COG2003	Belongs to the UPF0758 family
XCAW_01523	COG5489	Protein of unknown function (DUF736)
XCAW_01524	COG1396	sequence-specific DNA binding
XCAW_01525	COG2963	transposase activity
XCAW_01527	COG3002	Belongs to the UPF0753 family
XCAW_01528	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XCAW_01529	COG0583	DNA-binding transcription factor activity
XCAW_01532	COG2197	response regulator
XCAW_01535	COG1335	isochorismatase
XCAW_01539	COG2814	Major facilitator Superfamily
XCAW_01542	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XCAW_01542	COG1648	precorrin-2 dehydrogenase activity
XCAW_01545	COG3685	Protein conserved in bacteria
XCAW_01548	COG5001	Diguanylate cyclase
XCAW_01550	COG4566	intracellular signal transduction
XCAW_01558	COG3279	Response regulator of the LytR AlgR family
XCAW_01564	COG1238	metal cluster binding
XCAW_01566	COG2963	transposase activity
XCAW_01567	COG2801	Transposase and inactivated derivatives
XCAW_01583	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_01594	COG2154	pterin-4-alpha-carbinolamine dehydratase
XCAW_01595	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XCAW_01595	COG0316	Belongs to the HesB IscA family
XCAW_01597	COG0428	transporter
XCAW_01598	COG3064	Membrane
XCAW_01601	COG1530	ribonuclease E activity
XCAW_01607	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XCAW_01609	COG0582	viral genome integration into host DNA
XCAW_01610	COG2963	transposase activity
XCAW_01611	COG2801	Transposase and inactivated derivatives
XCAW_01614	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XCAW_01615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XCAW_01620	COG3039	Transposase
XCAW_01624	COG3039	Transposase
XCAW_01632	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
XCAW_01635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
XCAW_01644	COG1192	Involved in chromosome partitioning
XCAW_01651	COG0629	single-stranded DNA binding
XCAW_01652	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XCAW_01653	COG0270	DNA (cytosine-5-)-methyltransferase activity
XCAW_01663	COG2826	transposase and inactivated derivatives, IS30 family
XCAW_01690	COG2003	Belongs to the UPF0758 family
XCAW_01720	COG0583	DNA-binding transcription factor activity
XCAW_01721	COG1396	sequence-specific DNA binding
XCAW_01726	COG0582	viral genome integration into host DNA
XCAW_01728	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XCAW_01729	COG0322	excinuclease ABC activity
XCAW_01731	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XCAW_01732	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XCAW_01733	COG1663	tetraacyldisaccharide 4'-kinase activity
XCAW_01734	COG1132	(ABC) transporter
XCAW_01736	COG0811	peptide transport
XCAW_01739	COG1136	(ABC) transporter
XCAW_01740	COG4591	ABC-type transport system involved in lipoprotein release permease component
XCAW_01742	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XCAW_01743	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XCAW_01746	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XCAW_01751	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XCAW_01752	COG0837	glucose binding
XCAW_01753	COG0363	glucosamine-6-phosphate deaminase activity
XCAW_01754	COG0129	dihydroxy-acid dehydratase activity
XCAW_01755	COG0800	Aldolase
XCAW_01769	COG0784	Response regulator, receiver
XCAW_01769	COG2205	protein histidine kinase activity
XCAW_01770	COG2183	response to ionizing radiation
XCAW_01772	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCAW_01772	COG0723	plastoquinol--plastocyanin reductase activity
XCAW_01775	COG3243	poly(R)-hydroxyalkanoic acid synthase
XCAW_01777	COG1183	phosphatidylcholine synthase activity
XCAW_01778	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_01782	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XCAW_01784	COG0668	transmembrane transport
XCAW_01785	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XCAW_01786	COG0590	tRNA wobble adenosine to inosine editing
XCAW_01787	COG1321	iron dependent repressor
XCAW_01788	COG1914	H( )-stimulated, divalent metal cation uptake system
XCAW_01791	COG0746	molybdenum cofactor guanylyltransferase activity
XCAW_01792	COG0303	'Molybdopterin
XCAW_01794	COG0708	Exodeoxyribonuclease III
XCAW_01801	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XCAW_01802	COG0303	'Molybdopterin
XCAW_01803	COG1160	GTP binding
XCAW_01804	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCAW_01806	COG1426	Protein conserved in bacteria
XCAW_01808	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XCAW_01809	COG0105	UTP biosynthetic process
XCAW_01811	COG1250	3-hydroxyacyl-CoA dehydrogenase
XCAW_01811	COG1024	Enoyl-CoA hydratase
XCAW_01812	COG0183	Belongs to the thiolase family
XCAW_01813	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XCAW_01814	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XCAW_01816	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XCAW_01819	COG1674	ftsk spoiiie
XCAW_01821	COG0492	ferredoxin-NADP+ reductase activity
XCAW_01823	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XCAW_01824	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XCAW_01825	COG0542	response to heat
XCAW_01826	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XCAW_01828	COG0482	sulfurtransferase activity
XCAW_01829	COG2915	High frequency lysogenization protein hflD homolog
XCAW_01836	COG5002	protein histidine kinase activity
XCAW_01840	COG0784	Response regulator, receiver
XCAW_01840	COG0835	chemotaxis
XCAW_01842	COG1558	bacterial-type flagellum-dependent cell motility
XCAW_01843	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XCAW_01844	COG1749	Flagellar hook protein flgE
XCAW_01845	COG4787	bacterial-type flagellum-dependent cell motility
XCAW_01846	COG4786	Flagellar basal body rod
XCAW_01847	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XCAW_01848	COG1706	bacterial-type flagellum-dependent cell motility
XCAW_01849	COG1705	Flagellar rod assembly protein muramidase FlgJ
XCAW_01849	COG3951	Flagellar rod assembly protein muramidase FlgJ
XCAW_01851	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XCAW_01852	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XCAW_01853	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XCAW_01860	COG2201	protein-glutamate methylesterase activity
XCAW_01861	COG2204	response regulator
XCAW_01864	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCAW_01865	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_01866	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_01873	COG1677	Flagellar hook-basal body complex protein FliE
XCAW_01884	COG3190	flagellar
XCAW_01887	COG1987	bacterial-type flagellum assembly
XCAW_01888	COG1684	flagellar biosynthetic protein fliR
XCAW_01889	COG3300	MHYT domain
XCAW_01889	COG5001	Diguanylate cyclase
XCAW_01890	COG3300	MHYT domain
XCAW_01890	COG5001	Diguanylate cyclase
XCAW_01893	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XCAW_01896	COG0455	bacterial-type flagellum organization
XCAW_01900	COG2198	Histidine kinase
XCAW_01900	COG0643	Histidine kinase
XCAW_01903	COG0641	radical SAM
XCAW_01910	COG2963	transposase activity
XCAW_01911	COG2801	Transposase and inactivated derivatives
XCAW_01912	COG3002	Belongs to the UPF0753 family
XCAW_01923	COG0210	DNA helicase
XCAW_01940	COG2084	Dehydrogenase
XCAW_01944	COG2003	Belongs to the UPF0758 family
XCAW_01951	COG0582	viral genome integration into host DNA
XCAW_01952	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XCAW_01952	COG0519	Catalyzes the synthesis of GMP from XMP
XCAW_01954	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XCAW_01956	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XCAW_01956	COG0475	glutathione-regulated potassium exporter activity
XCAW_01957	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XCAW_01959	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XCAW_01960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XCAW_01962	COG0776	regulation of translation
XCAW_01963	COG0539	negative regulation of cytoplasmic translation
XCAW_01964	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XCAW_01965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XCAW_01967	COG2957	Belongs to the agmatine deiminase family
XCAW_01968	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XCAW_01973	COG0395	ABC-type sugar transport system, permease component
XCAW_01974	COG1175	transmembrane transport
XCAW_01980	COG2350	Protein conserved in bacteria
XCAW_01981	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XCAW_01982	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XCAW_01983	COG1187	pseudouridine synthase activity
XCAW_01987	COG0436	Aminotransferase
XCAW_01988	COG4133	protoheme IX ABC transporter activity
XCAW_01992	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XCAW_01993	COG1138	Cytochrome C-type biogenesis protein
XCAW_01997	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XCAW_01998	COG1278	Cold shock
XCAW_01999	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XCAW_02000	COG4988	ABC transporter
XCAW_02002	COG1294	oxidase, subunit
XCAW_02007	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XCAW_02008	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XCAW_02010	COG0165	Argininosuccinate lyase
XCAW_02011	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XCAW_02013	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XCAW_02016	COG0137	argininosuccinate synthase activity
XCAW_02017	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XCAW_02020	COG0215	cysteine-tRNA ligase activity
XCAW_02021	COG2166	iron-sulfur cluster assembly
XCAW_02023	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XCAW_02024	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XCAW_02025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XCAW_02031	COG4302	ethanolamine ammonia-lyase activity
XCAW_02037	COG2963	transposase activity
XCAW_02042	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XCAW_02043	COG0402	S-adenosylhomocysteine deaminase activity
XCAW_02045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XCAW_02046	COG1509	lysine 2,3-aminomutase activity
XCAW_02047	COG3300	MHYT domain
XCAW_02047	COG5001	Diguanylate cyclase
XCAW_02050	COG0483	inositol monophosphate 1-phosphatase activity
XCAW_02055	COG0513	Belongs to the DEAD box helicase family
XCAW_02056	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XCAW_02057	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XCAW_02059	COG0625	glutathione transferase activity
XCAW_02061	COG4681	YaeQ
XCAW_02062	COG2081	HI0933 family
XCAW_02064	COG0501	Belongs to the peptidase M48B family
XCAW_02065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XCAW_02066	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_02070	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XCAW_02072	COG0860	N-Acetylmuramoyl-L-alanine amidase
XCAW_02073	COG0802	atpase or kinase
XCAW_02074	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XCAW_02074	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XCAW_02075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XCAW_02076	COG1570	exodeoxyribonuclease VII activity
XCAW_02078	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XCAW_02119	COG0835	chemotaxis
XCAW_02120	COG0840	transmembrane signaling receptor activity
XCAW_02121	COG2094	Belongs to the DNA glycosylase MPG family
XCAW_02122	COG1201	RNA secondary structure unwinding
XCAW_02125	COG2969	positive regulation of protein catabolic process
XCAW_02126	COG0625	glutathione transferase activity
XCAW_02127	COG2857	Cytochrome c1
XCAW_02128	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XCAW_02129	COG0723	plastoquinol--plastocyanin reductase activity
XCAW_02131	COG0741	lytic transglycosylase activity
XCAW_02134	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XCAW_02135	COG1702	phosphate starvation-inducible protein PhoH
XCAW_02137	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XCAW_02139	COG4535	Mg2 and Co2 transporter CorC
XCAW_02142	COG1012	belongs to the aldehyde dehydrogenase family
XCAW_02143	COG1177	transmembrane transport
XCAW_02144	COG1176	ABC-type spermidine putrescine transport system, permease component I
XCAW_02145	COG3842	ATPase activity
XCAW_02149	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XCAW_02152	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XCAW_02153	COG0174	glutamine synthetase
XCAW_02154	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCAW_02155	COG0745	RESPONSE REGULATOR receiver
XCAW_02155	COG3706	GGDEF domain
XCAW_02156	COG2703	oxygen carrier activity
XCAW_02157	COG0477	Major facilitator Superfamily
XCAW_02159	COG0243	molybdopterin cofactor binding
XCAW_02160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XCAW_02165	COG2733	membrane
XCAW_02166	COG5002	protein histidine kinase activity
XCAW_02166	COG2205	protein histidine kinase activity
XCAW_02166	COG0784	Response regulator, receiver
XCAW_02168	COG0477	Major facilitator Superfamily
XCAW_02171	COG2902	Dehydrogenase
XCAW_02173	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCAW_02174	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCAW_02175	COG1609	Transcriptional regulator
XCAW_02176	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XCAW_02176	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XCAW_02177	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XCAW_02177	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XCAW_02178	COG1105	Belongs to the carbohydrate kinase PfkB family
XCAW_02179	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XCAW_02179	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XCAW_02187	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XCAW_02189	COG1862	Preprotein translocase
XCAW_02190	COG0343	queuine tRNA-ribosyltransferase activity
XCAW_02191	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XCAW_02198	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XCAW_02199	COG3291	Pkd domain containing protein
XCAW_02200	COG0405	Gamma-glutamyltransferase
XCAW_02201	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XCAW_02203	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XCAW_02204	COG0742	ribosomal rna small subunit methyltransferase
XCAW_02205	COG0326	Molecular chaperone. Has ATPase activity
XCAW_02221	COG0531	amino acid
XCAW_02224	COG0006	proline dipeptidase activity
XCAW_02226	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XCAW_02229	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCAW_02230	COG3938	Belongs to the proline racemase family
XCAW_02232	COG0552	protein localization to endoplasmic reticulum
XCAW_02233	COG1194	a g-specific adenine glycosylase
XCAW_02234	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XCAW_02235	COG4191	Histidine kinase
XCAW_02235	COG0784	Response regulator, receiver
XCAW_02238	COG0322	excinuclease ABC activity
XCAW_02241	COG3040	lipid binding
XCAW_02244	COG1960	acyl-CoA dehydrogenase activity
XCAW_02246	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XCAW_02250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XCAW_02251	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCAW_02252	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XCAW_02259	COG0438	transferase activity, transferring glycosyl groups
XCAW_02260	COG0438	transferase activity, transferring glycosyl groups
XCAW_02269	COG0776	regulation of translation
XCAW_02270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XCAW_02270	COG0072	phenylalanine-tRNA ligase activity
XCAW_02271	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XCAW_02272	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XCAW_02273	COG0291	Belongs to the bacterial ribosomal protein bL35 family
XCAW_02274	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XCAW_02275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XCAW_02280	COG1082	Xylose isomerase domain protein TIM barrel
XCAW_02284	COG0366	Alpha amylase catalytic
XCAW_02285	COG2963	transposase activity
XCAW_02286	COG2801	Transposase and inactivated derivatives
XCAW_02289	COG0477	Major facilitator Superfamily
XCAW_02290	COG2115	Belongs to the xylose isomerase family
XCAW_02291	COG1070	Carbohydrate kinase
XCAW_02293	COG1501	Belongs to the glycosyl hydrolase 31 family
XCAW_02302	COG0800	Aldolase
XCAW_02303	COG4948	Mandelate Racemase Muconate Lactonizing
XCAW_02305	COG3734	2-keto-3-deoxy-galactonokinase
XCAW_02306	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XCAW_02308	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XCAW_02311	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XCAW_02312	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XCAW_02315	COG0351	phosphomethylpyrimidine kinase
XCAW_02315	COG0352	thiamine-phosphate diphosphorylase activity
XCAW_02320	COG0583	DNA-binding transcription factor activity
XCAW_02321	COG1741	Belongs to the pirin family
XCAW_02325	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XCAW_02326	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XCAW_02327	COG2137	regulation of response to DNA damage stimulus
XCAW_02328	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XCAW_02329	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XCAW_02332	COG1546	Belongs to the CinA family
XCAW_02333	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XCAW_02334	COG1923	regulation of RNA biosynthetic process
XCAW_02335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XCAW_02336	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XCAW_02337	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XCAW_02338	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XCAW_02339	COG1534	Rna-binding protein
XCAW_02343	COG1238	metal cluster binding
XCAW_02344	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XCAW_02345	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XCAW_02346	COG2840	Smr protein MutS2
XCAW_02347	COG0585	pseudouridine synthase activity
XCAW_02348	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XCAW_02349	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XCAW_02350	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XCAW_02351	COG0148	phosphopyruvate hydratase activity
XCAW_02353	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XCAW_02354	COG0504	CTP synthase activity
XCAW_02360	COG0306	phosphate transporter
XCAW_02363	COG1253	flavin adenine dinucleotide binding
XCAW_02366	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCAW_02367	COG0477	Major facilitator Superfamily
XCAW_02369	COG1136	(ABC) transporter
XCAW_02372	COG0438	transferase activity, transferring glycosyl groups
XCAW_02374	COG2264	protein methyltransferase activity
XCAW_02380	COG2244	polysaccharide biosynthetic process
XCAW_02390	COG1595	DNA-templated transcription, initiation
XCAW_02393	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XCAW_02395	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XCAW_02397	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XCAW_02400	COG4191	Histidine kinase
XCAW_02400	COG0784	Response regulator, receiver
XCAW_02401	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XCAW_02402	COG0745	RESPONSE REGULATOR receiver
XCAW_02407	COG0840	transmembrane signaling receptor activity
XCAW_02413	COG2801	Transposase and inactivated derivatives
XCAW_02414	COG2963	transposase activity
XCAW_02415	COG1396	sequence-specific DNA binding
XCAW_02416	COG5489	Protein of unknown function (DUF736)
XCAW_02418	COG2003	Belongs to the UPF0758 family
XCAW_02423	COG0582	viral genome integration into host DNA
XCAW_02426	COG4774	siderophore transport
XCAW_02430	COG2336	PFAM SpoVT AbrB
XCAW_02435	COG4206	TonB-dependent receptor
XCAW_02438	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
XCAW_02438	COG2273	Hydrolase Family 16
XCAW_02442	COG2274	protein secretion by the type I secretion system
XCAW_02445	COG1192	Involved in chromosome partitioning
XCAW_02455	COG0270	DNA (cytosine-5-)-methyltransferase activity
XCAW_02465	COG4804	nuclease activity
XCAW_02466	COG2963	transposase activity
XCAW_02467	COG2801	Transposase and inactivated derivatives
XCAW_02468	COG3002	Belongs to the UPF0753 family
XCAW_02483	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XCAW_02484	COG1360	Flagellar Motor Protein
XCAW_02485	COG1192	Involved in chromosome partitioning
XCAW_02486	COG0835	chemotaxis
XCAW_02488	COG0745	RESPONSE REGULATOR receiver
XCAW_02489	COG2198	Histidine kinase
XCAW_02489	COG0643	Histidine kinase
XCAW_02490	COG0840	transmembrane signaling receptor activity
XCAW_02492	COG0840	transmembrane signaling receptor activity
XCAW_02492	COG0840	transmembrane signaling receptor activity
XCAW_02493	COG0840	transmembrane signaling receptor activity
XCAW_02495	COG0840	transmembrane signaling receptor activity
XCAW_02496	COG0840	transmembrane signaling receptor activity
XCAW_02497	COG0840	transmembrane signaling receptor activity
XCAW_02498	COG0840	transmembrane signaling receptor activity
XCAW_02499	COG0840	transmembrane signaling receptor activity
XCAW_02500	COG0840	transmembrane signaling receptor activity
XCAW_02501	COG0840	transmembrane signaling receptor activity
XCAW_02502	COG0840	transmembrane signaling receptor activity
XCAW_02504	COG0840	transmembrane signaling receptor activity
XCAW_02506	COG0835	chemotaxis
XCAW_02508	COG0840	transmembrane signaling receptor activity
XCAW_02510	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XCAW_02511	COG2201	protein-glutamate methylesterase activity
XCAW_02513	COG2267	carboxylic ester hydrolase activity
XCAW_02519	COG0318	PFAM AMP-dependent synthetase and ligase
XCAW_02520	COG1024	Enoyl-CoA hydratase
XCAW_02521	COG2205	protein histidine kinase activity
XCAW_02521	COG2198	Histidine kinase
XCAW_02521	COG0784	Response regulator, receiver
XCAW_02523	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XCAW_02524	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XCAW_02525	COG3279	Response regulator of the LytR AlgR family
XCAW_02534	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XCAW_02536	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XCAW_02537	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XCAW_02539	COG0505	Belongs to the CarA family
XCAW_02540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XCAW_02541	COG2258	MOSC domain
XCAW_02542	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XCAW_02552	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XCAW_02556	COG0277	FAD linked oxidase domain protein
XCAW_02557	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XCAW_02559	COG0531	amino acid
XCAW_02560	COG0531	amino acid
XCAW_02561	COG0235	Class ii aldolase
XCAW_02562	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XCAW_02563	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XCAW_02566	COG0140	phosphoribosyl-ATP diphosphatase activity
XCAW_02566	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XCAW_02567	COG0107	imidazoleglycerol-phosphate synthase activity
XCAW_02568	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XCAW_02569	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XCAW_02570	COG0131	Imidazoleglycerol-phosphate dehydratase
XCAW_02570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XCAW_02571	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XCAW_02572	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XCAW_02573	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XCAW_02575	COG0124	histidyl-tRNA synthetase
XCAW_02576	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XCAW_02586	COG3210	domain, Protein
XCAW_02588	COG3210	domain, Protein
XCAW_02592	COG1649	PFAM Uncharacterised BCR, COG1649
XCAW_02592	COG0726	polysaccharide deacetylase
XCAW_02593	COG1215	transferase activity, transferring glycosyl groups
XCAW_02596	COG1012	belongs to the aldehyde dehydrogenase family
XCAW_02600	COG0167	dihydroorotate dehydrogenase activity
XCAW_02601	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XCAW_02602	COG0697	spore germination
XCAW_02603	COG1794	racemase activity, acting on amino acids and derivatives
XCAW_02605	COG0671	phosphoesterase, PA-phosphatase related
XCAW_02606	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XCAW_02608	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XCAW_02609	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCAW_02610	COG2203	Gaf domain
XCAW_02610	COG5001	Diguanylate cyclase
XCAW_02610	COG3706	GGDEF domain
XCAW_02610	COG4251	negative regulation of phosphorylation
XCAW_02612	COG1472	Belongs to the glycosyl hydrolase 3 family
XCAW_02617	COG0166	Belongs to the GPI family
XCAW_02618	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XCAW_02619	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XCAW_02620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XCAW_02624	COG1469	GTP cyclohydrolase I activity
XCAW_02625	COG0860	N-Acetylmuramoyl-L-alanine amidase
XCAW_02627	COG0366	Alpha amylase catalytic
XCAW_02628	COG2963	transposase activity
XCAW_02629	COG2801	Transposase and inactivated derivatives
XCAW_02643	COG2948	multi-organism process
XCAW_02647	COG3505	Type IV secretory pathway VirD4
XCAW_02650	COG0556	nucleotide-excision repair
XCAW_02659	COG2963	transposase activity
XCAW_02660	COG2801	Transposase and inactivated derivatives
XCAW_02668	COG0583	DNA-binding transcription factor activity
XCAW_02669	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XCAW_02670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XCAW_02673	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XCAW_02674	COG0077	Prephenate dehydratase
XCAW_02674	COG1605	Chorismate mutase
XCAW_02675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XCAW_02676	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XCAW_02677	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XCAW_02685	COG1228	amidohydrolase
XCAW_02686	COG2986	histidine ammonia-lyase
XCAW_02688	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XCAW_02692	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XCAW_02694	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XCAW_02695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XCAW_02696	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XCAW_02698	COG3115	cell septum assembly
XCAW_02700	COG0359	binds to the 23S rRNA
XCAW_02701	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XCAW_02702	COG0360	Binds together with S18 to 16S ribosomal RNA
XCAW_02703	COG0316	Belongs to the HesB IscA family
XCAW_02704	COG0017	Asparaginyl-tRNA synthetase
XCAW_02708	COG2808	Putative FMN-binding domain
XCAW_02720	COG0288	reversible hydration of carbon dioxide
XCAW_02721	COG0662	Cupin 2, conserved barrel domain protein
XCAW_02723	COG3844	kynureninase activity
XCAW_02724	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCAW_02726	COG2925	Exonuclease
XCAW_02730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XCAW_02731	COG0116	Belongs to the methyltransferase superfamily
XCAW_02731	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XCAW_02739	COG0494	nUDIX hydrolase
XCAW_02741	COG1024	Enoyl-CoA hydratase
XCAW_02743	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XCAW_02744	COG0659	secondary active sulfate transmembrane transporter activity
XCAW_02750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XCAW_02751	COG0573	inorganic phosphate transmembrane transporter activity
XCAW_02752	COG0581	inorganic phosphate transmembrane transporter activity
XCAW_02753	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XCAW_02754	COG0704	Plays a role in the regulation of phosphate uptake
XCAW_02756	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XCAW_02757	COG3706	GGDEF domain
XCAW_02758	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XCAW_02760	COG0557	exoribonuclease II activity
XCAW_02763	COG1960	acyl-CoA dehydrogenase activity
XCAW_02765	COG0646	methionine synthase
XCAW_02765	COG1410	methionine synthase
XCAW_02766	COG1410	methionine synthase
XCAW_02766	COG0646	methionine synthase
XCAW_02768	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XCAW_02773	COG2900	Belongs to the SlyX family
XCAW_02776	COG0386	Belongs to the glutathione peroxidase family
XCAW_02778	COG1725	Transcriptional regulator
XCAW_02779	COG1131	(ABC) transporter
XCAW_02785	COG1253	flavin adenine dinucleotide binding
XCAW_02789	COG2850	peptidyl-arginine hydroxylation
XCAW_02796	COG1132	(ABC) transporter
XCAW_02797	COG0583	DNA-binding transcription factor activity
XCAW_02803	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XCAW_02805	COG0484	heat shock protein binding
XCAW_02806	COG0443	Heat shock 70 kDa protein
XCAW_02807	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XCAW_02808	COG1420	regulation of RNA biosynthetic process
XCAW_02809	COG0497	DNA recombination
XCAW_02811	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCAW_02814	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XCAW_02854	COG3706	GGDEF domain
XCAW_02856	COG3706	GGDEF domain
XCAW_02862	COG0583	DNA-binding transcription factor activity
XCAW_02865	COG0415	Belongs to the DNA photolyase family
XCAW_02866	COG0305	Participates in initiation and elongation during chromosome replication
XCAW_02868	COG0367	asparagine synthase
XCAW_02871	COG1960	acyl-CoA dehydrogenase activity
XCAW_02874	COG0084	hydrolase, TatD family'
XCAW_02875	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XCAW_02886	COG0386	Belongs to the glutathione peroxidase family
XCAW_02887	COG0339	signal peptide processing
XCAW_02893	COG3104	oligopeptide transport
XCAW_02897	COG2814	Major facilitator Superfamily
XCAW_02898	COG1566	PFAM secretion protein HlyD family protein
XCAW_02904	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XCAW_02908	COG4774	siderophore transport
XCAW_02910	COG0367	asparagine synthase
XCAW_02911	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XCAW_02912	COG1393	Belongs to the ArsC family
XCAW_02914	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XCAW_02915	COG0024	Methionine aminopeptidase
XCAW_02922	COG0052	Belongs to the universal ribosomal protein uS2 family
XCAW_02923	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XCAW_02924	COG0745	RESPONSE REGULATOR receiver
XCAW_02924	COG3706	GGDEF domain
XCAW_02925	COG0528	UMP kinase activity
XCAW_02926	COG0233	cytoplasmic translational termination
XCAW_02927	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XCAW_02928	COG0575	Belongs to the CDS family
XCAW_02929	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XCAW_02930	COG0750	zinc metalloprotease
XCAW_02933	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCAW_02934	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XCAW_02935	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCAW_02936	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCAW_02937	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XCAW_02939	COG0825	malonyl-CoA metabolic process
XCAW_02946	COG1695	Transcriptional regulator
XCAW_02950	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XCAW_02952	COG2040	homocysteine
XCAW_02953	COG0833	amino acid
XCAW_02954	COG0346	lactoylglutathione lyase activity
XCAW_02955	COG1131	(ABC) transporter
XCAW_02958	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XCAW_02958	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XCAW_02961	COG2878	Part of a membrane complex involved in electron transport
XCAW_02964	COG1595	DNA-templated transcription, initiation
XCAW_02969	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XCAW_02972	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XCAW_02973	COG0251	oxidation-reduction process
XCAW_02975	COG0392	lysyltransferase activity
XCAW_02975	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XCAW_02982	COG2814	Major facilitator Superfamily
XCAW_02983	COG1902	pentaerythritol trinitrate reductase activity
XCAW_02985	COG2824	Alkylphosphonate utilization operon protein PhnA
XCAW_02987	COG1047	Peptidyl-prolyl cis-trans
XCAW_02988	COG1077	Cell shape determining protein MreB Mrl
XCAW_02991	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XCAW_02993	COG5487	UPF0391 membrane protein
XCAW_02994	COG1451	nucleotide metabolic process
XCAW_02998	COG0183	Belongs to the thiolase family
XCAW_03003	COG3706	GGDEF domain
XCAW_03003	COG0745	RESPONSE REGULATOR receiver
XCAW_03006	COG1793	dna ligase
XCAW_03006	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XCAW_03007	COG1793	dna ligase
XCAW_03008	COG1201	RNA secondary structure unwinding
XCAW_03010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCAW_03011	COG1278	Cold shock
XCAW_03012	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XCAW_03014	COG1472	Belongs to the glycosyl hydrolase 3 family
XCAW_03015	COG3046	protein related to deoxyribodipyrimidine photolyase
XCAW_03016	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
XCAW_03017	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XCAW_03019	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XCAW_03021	COG1381	Involved in DNA repair and RecF pathway recombination
XCAW_03022	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XCAW_03023	COG0571	ribonuclease III activity
XCAW_03026	COG0481	GTPase activity
XCAW_03027	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XCAW_03030	COG1250	3-hydroxyacyl-CoA dehydrogenase
XCAW_03030	COG1024	Enoyl-CoA hydratase
XCAW_03034	COG1024	Enoyl-CoA hydratase
XCAW_03035	COG1960	acyl-CoA dehydrogenase activity
XCAW_03039	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XCAW_03040	COG3250	beta-galactosidase activity
XCAW_03044	COG3209	COG3209 Rhs family protein
XCAW_03047	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XCAW_03050	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XCAW_03054	COG0534	Mate efflux family protein
XCAW_03056	COG0335	large ribosomal subunit rRNA binding
XCAW_03057	COG0336	Belongs to the RNA methyltransferase TrmD family
XCAW_03058	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XCAW_03059	COG0228	four-way junction DNA binding
XCAW_03060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XCAW_03062	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XCAW_03063	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XCAW_03068	COG4191	Histidine kinase
XCAW_03068	COG0784	Response regulator, receiver
XCAW_03069	COG3850	Histidine kinase
XCAW_03069	COG3437	response regulator, receiver
XCAW_03069	COG2205	protein histidine kinase activity
XCAW_03069	COG4999	Histidine kinase
XCAW_03070	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XCAW_03072	COG2205	protein histidine kinase activity
XCAW_03073	COG5507	3-demethylubiquinone-9 3-methyltransferase
XCAW_03075	COG4771	TonB-dependent receptor
XCAW_03080	COG2172	sigma factor antagonist activity
XCAW_03081	COG1366	Belongs to the anti-sigma-factor antagonist family
XCAW_03082	COG1366	Belongs to the anti-sigma-factor antagonist family
XCAW_03084	COG0326	Molecular chaperone. Has ATPase activity
XCAW_03086	COG2207	Transcriptional regulator
XCAW_03089	COG3152	Membrane
XCAW_03092	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XCAW_03093	COG1845	cytochrome c oxidase, subunit III
XCAW_03094	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XCAW_03097	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XCAW_03098	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XCAW_03099	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XCAW_03100	COG0196	riboflavin kinase activity
XCAW_03102	COG0268	Binds directly to 16S ribosomal RNA
XCAW_03103	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XCAW_03104	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XCAW_03105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XCAW_03106	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XCAW_03107	COG0824	Thioesterase
XCAW_03110	COG1946	Acyl-CoA thioesterase
XCAW_03114	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XCAW_03116	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XCAW_03121	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XCAW_03124	COG2197	response regulator
XCAW_03125	COG4585	Histidine kinase
XCAW_03127	COG0850	regulation of cytokinetic process
XCAW_03128	COG2894	cell division
XCAW_03129	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XCAW_03131	COG0642	Histidine kinase
XCAW_03132	COG0745	RESPONSE REGULATOR receiver
XCAW_03135	COG2194	sulfuric ester hydrolase activity
XCAW_03138	COG2814	Major facilitator Superfamily
XCAW_03139	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XCAW_03139	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XCAW_03141	COG0656	L-ascorbic acid biosynthetic process
XCAW_03143	COG0753	catalase activity
XCAW_03150	COG2198	Histidine kinase
XCAW_03150	COG0643	Histidine kinase
XCAW_03151	COG0840	transmembrane signaling receptor activity
XCAW_03152	COG0835	chemotaxis
XCAW_03153	COG2200	EAL domain
XCAW_03153	COG2202	Pas domain
XCAW_03153	COG2199	diguanylate cyclase activity
XCAW_03154	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XCAW_03155	COG2201	protein-glutamate methylesterase activity
XCAW_03156	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCAW_03157	COG3590	peptidase
XCAW_03159	COG0588	phosphoglycerate mutase activity
XCAW_03160	COG1515	deoxyribonuclease V activity
XCAW_03162	COG1741	Belongs to the pirin family
XCAW_03165	COG1741	Belongs to the pirin family
XCAW_03166	COG1966	Carbon starvation protein
XCAW_03167	COG2879	small protein
XCAW_03176	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XCAW_03177	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XCAW_03178	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XCAW_03179	COG2080	2 iron, 2 sulfur cluster binding
XCAW_03181	COG4251	negative regulation of phosphorylation
XCAW_03181	COG5001	Diguanylate cyclase
XCAW_03181	COG2203	Gaf domain
XCAW_03181	COG3706	GGDEF domain
XCAW_03182	COG0629	single-stranded DNA binding
XCAW_03183	COG0142	geranyltranstransferase activity
XCAW_03185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XCAW_03188	COG0527	aspartate kinase activity
XCAW_03190	COG0384	phenazine biosynthesis protein PhzF
XCAW_03191	COG0384	phenazine biosynthesis protein PhzF
XCAW_03193	COG1764	response to oxidative stress
XCAW_03194	COG0540	Belongs to the ATCase OTCase family
XCAW_03195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XCAW_03196	COG1678	Uncharacterized ACR, COG1678
XCAW_03197	COG0519	Catalyzes the synthesis of GMP from XMP
XCAW_03200	COG5297	Belongs to the glycosyl hydrolase family 6
XCAW_03203	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XCAW_03206	COG0739	heme binding
XCAW_03210	COG0693	protein deglycase activity
XCAW_03212	COG1959	2 iron, 2 sulfur cluster binding
XCAW_03213	COG0719	Fe-S assembly protein
XCAW_03214	COG0396	ATPase activity
XCAW_03215	COG0719	Fe-S assembly protein
XCAW_03216	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XCAW_03219	COG4774	siderophore transport
XCAW_03220	COG3128	pkhd-type hydroxylase
XCAW_03225	COG1477	protein flavinylation
XCAW_03226	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XCAW_03229	COG1555	photosystem II stabilization
XCAW_03230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XCAW_03232	COG3178	'Phosphotransferase
XCAW_03233	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XCAW_03235	COG0628	permease
XCAW_03237	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XCAW_03239	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XCAW_03243	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XCAW_03244	COG0271	Belongs to the BolA IbaG family
XCAW_03246	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XCAW_03248	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XCAW_03249	COG1137	ATPase activity
XCAW_03252	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XCAW_03253	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XCAW_03254	COG1660	Displays ATPase and GTPase activities
XCAW_03256	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XCAW_03257	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XCAW_03258	COG2239	Acts as a magnesium transporter
XCAW_03260	COG1294	oxidase, subunit
XCAW_03261	COG1271	oxidase subunit
XCAW_03263	COG1113	amino acid transport
XCAW_03266	COG2197	response regulator
XCAW_03267	COG0531	amino acid
XCAW_03273	COG1234	tRNA 3'-trailer cleavage
XCAW_03281	COG2814	Major facilitator Superfamily
XCAW_03283	COG0754	glutathionylspermidine amidase activity
XCAW_03288	COG1842	Phage shock protein A
XCAW_03290	COG0259	pyridoxamine-phosphate oxidase activity
XCAW_03291	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XCAW_03292	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XCAW_03294	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XCAW_03310	COG0477	Major facilitator Superfamily
XCAW_03315	COG2205	protein histidine kinase activity
XCAW_03315	COG2198	Histidine kinase
XCAW_03315	COG0784	Response regulator, receiver
XCAW_03316	COG2353	YceI-like domain
XCAW_03320	COG1760	l-serine dehydratase
XCAW_03322	COG0527	aspartate kinase activity
XCAW_03322	COG0460	homoserine dehydrogenase
XCAW_03323	COG0626	cystathionine gamma-synthase activity
XCAW_03324	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XCAW_03325	COG0739	heme binding
XCAW_03326	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XCAW_03327	COG1272	protein, Hemolysin III
XCAW_03328	COG2982	Protein involved in outer membrane biogenesis
XCAW_03329	COG0517	IMP dehydrogenase activity
XCAW_03329	COG0516	GMP reductase activity
XCAW_03330	COG0463	Glycosyl transferase, family 2
XCAW_03331	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XCAW_03332	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XCAW_03334	COG4771	TonB-dependent receptor
XCAW_03338	COG1309	transcriptional regulator
XCAW_03339	COG2267	carboxylic ester hydrolase activity
XCAW_03340	COG1960	acyl-CoA dehydrogenase activity
XCAW_03345	COG0509	glycine decarboxylation via glycine cleavage system
XCAW_03346	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XCAW_03348	COG0330	HflC and HflK could
XCAW_03350	COG1742	UPF0060 membrane protein
XCAW_03351	COG3956	TIGRFAM MazG family protein
XCAW_03353	COG0494	nUDIX hydrolase
XCAW_03355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XCAW_03356	COG0837	glucose binding
XCAW_03360	COG1388	LysM domain
XCAW_03360	COG3858	chitin binding
XCAW_03361	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XCAW_03363	COG1472	Belongs to the glycosyl hydrolase 3 family
XCAW_03366	COG0531	amino acid
XCAW_03368	COG1486	melibiose metabolic process
XCAW_03370	COG3537	Alpha-1,2-mannosidase
XCAW_03377	COG3142	Participates in the control of copper homeostasis
XCAW_03378	COG1446	asparaginase
XCAW_03385	COG0840	transmembrane signaling receptor activity
XCAW_03390	COG0189	ligase activity
XCAW_03392	COG1397	ADP-ribosylglycohydrolase
XCAW_03394	COG1199	ATP-dependent helicase activity
XCAW_03396	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XCAW_03397	COG1215	transferase activity, transferring glycosyl groups
XCAW_03399	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XCAW_03400	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XCAW_03401	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XCAW_03402	COG0535	radical SAM domain protein
XCAW_03403	COG0535	radical SAM domain protein
XCAW_03406	COG0837	glucose binding
XCAW_03408	COG1643	Atp-dependent helicase
XCAW_03409	COG0783	Belongs to the Dps family
XCAW_03410	COG0514	ATP-dependent DNA helicase (RecQ)
XCAW_03417	COG0840	transmembrane signaling receptor activity
XCAW_03421	COG3920	Histidine kinase
XCAW_03422	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XCAW_03424	COG0602	queuosine metabolic process
XCAW_03426	COG2885	chlorophyll binding
XCAW_03427	COG0823	Involved in the tonB-independent uptake of proteins
XCAW_03429	COG0848	biopolymer transport protein
XCAW_03431	COG0824	Thioesterase
XCAW_03432	COG2255	four-way junction helicase activity
XCAW_03434	COG3158	transport of potassium into the cell
XCAW_03435	COG0632	four-way junction helicase activity
XCAW_03436	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XCAW_03437	COG0217	transcriptional regulatory protein
XCAW_03440	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XCAW_03443	COG0477	Major facilitator Superfamily
XCAW_03451	COG0488	(ABC) transporter
XCAW_03458	COG4651	solute:proton antiporter activity
XCAW_03458	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XCAW_03463	COG4772	TonB-dependent receptor
XCAW_03465	COG4264	IucA IucC family
XCAW_03468	COG0019	diaminopimelate decarboxylase activity
XCAW_03473	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XCAW_03475	COG1492	cobalamin metabolic process
XCAW_03477	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XCAW_03481	COG4206	TonB-dependent receptor
XCAW_03482	COG0542	response to heat
XCAW_03483	COG1116	anion transmembrane transporter activity
XCAW_03484	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XCAW_03485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XCAW_03486	COG0667	Aldo Keto reductase
XCAW_03488	COG4771	TonB-dependent receptor
XCAW_03490	COG2827	Endonuclease containing a URI domain
XCAW_03499	COG1877	trehalose-phosphatase activity
XCAW_03500	COG3387	PFAM Glycoside hydrolase 15-related
XCAW_03503	COG0840	transmembrane signaling receptor activity
XCAW_03504	COG3011	Protein conserved in bacteria
XCAW_03507	COG0564	pseudouridine synthase activity
XCAW_03508	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XCAW_03510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XCAW_03510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XCAW_03511	COG2963	transposase activity
XCAW_03513	COG2801	Transposase and inactivated derivatives
XCAW_03516	COG2951	lytic endotransglycosylase activity
XCAW_03517	COG4644	lycopene metabolic process
XCAW_03527	COG2963	transposase activity
XCAW_03528	COG2801	Transposase and inactivated derivatives
XCAW_03534	COG0473	3-isopropylmalate dehydrogenase activity
XCAW_03537	COG4783	chaperone-mediated protein folding
XCAW_03540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XCAW_03542	COG0438	transferase activity, transferring glycosyl groups
XCAW_03543	COG0671	phosphoesterase, PA-phosphatase related
XCAW_03546	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XCAW_03548	COG3291	Pkd domain containing protein
XCAW_03553	COG0285	dihydrofolate synthase activity
XCAW_03554	COG0406	alpha-ribazole phosphatase activity
XCAW_03560	COG1063	alcohol dehydrogenase
XCAW_03562	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XCAW_03563	COG4208	sulfate ABC transporter
XCAW_03564	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XCAW_03565	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XCAW_03566	COG0156	8-amino-7-oxononanoate synthase activity
XCAW_03571	COG0604	alcohol dehydrogenase
XCAW_03572	COG0446	pyridine nucleotide-disulphide oxidoreductase
XCAW_03572	COG1902	pentaerythritol trinitrate reductase activity
XCAW_03575	COG0625	glutathione transferase activity
XCAW_03576	COG0039	L-malate dehydrogenase activity
XCAW_03577	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XCAW_03580	COG0154	amidase activity
XCAW_03582	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XCAW_03584	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XCAW_03585	COG0203	ribosomal protein L17
XCAW_03586	COG0202	RNA polymerase activity
XCAW_03587	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XCAW_03588	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XCAW_03589	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XCAW_03590	COG0201	protein transport
XCAW_03591	COG0200	Binds to the 23S rRNA
XCAW_03592	COG1841	ribosomal large subunit assembly
XCAW_03593	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XCAW_03594	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XCAW_03595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XCAW_03596	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XCAW_03597	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XCAW_03598	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XCAW_03599	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XCAW_03600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XCAW_03601	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XCAW_03602	COG0255	Belongs to the universal ribosomal protein uL29 family
XCAW_03603	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XCAW_03604	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XCAW_03605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XCAW_03606	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XCAW_03607	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XCAW_03608	COG0089	rRNA binding
XCAW_03609	COG0088	Forms part of the polypeptide exit tunnel
XCAW_03610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XCAW_03611	COG0051	transcription antitermination factor activity, RNA binding
XCAW_03612	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XCAW_03613	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XCAW_03614	COG0049	tRNA binding
XCAW_03615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XCAW_03616	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XCAW_03617	COG0085	RNA polymerase activity
XCAW_03618	COG0222	ribosome binding
XCAW_03619	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XCAW_03620	COG0081	regulation of translation
XCAW_03621	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XCAW_03622	COG0250	Participates in transcription elongation, termination and antitermination
XCAW_03623	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XCAW_03625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XCAW_03629	COG0012	GTP binding
XCAW_03630	COG0193	aminoacyl-tRNA hydrolase activity
XCAW_03631	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XCAW_03632	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XCAW_03634	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XCAW_03635	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XCAW_03637	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XCAW_03638	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XCAW_03640	COG0521	Mo-molybdopterin cofactor biosynthetic process
XCAW_03643	COG1254	Belongs to the acylphosphatase family
XCAW_03644	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XCAW_03645	COG1295	ribonuclease BN
XCAW_03651	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XCAW_03652	COG1404	Belongs to the peptidase S8 family
XCAW_03653	COG1404	Belongs to the peptidase S8 family
XCAW_03654	COG1404	Belongs to the peptidase S8 family
XCAW_03655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XCAW_03658	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XCAW_03659	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XCAW_03663	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XCAW_03669	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XCAW_03669	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XCAW_03673	COG2890	protein-(glutamine-N5) methyltransferase activity
XCAW_03675	COG3634	alkyl hydroperoxide reductase activity
XCAW_03676	COG0583	DNA-binding transcription factor activity
XCAW_03677	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XCAW_03678	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XCAW_03680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XCAW_03682	COG2197	response regulator
XCAW_03683	COG0784	Response regulator, receiver
XCAW_03683	COG2205	protein histidine kinase activity
XCAW_03683	COG5002	protein histidine kinase activity
XCAW_03684	COG3706	GGDEF domain
XCAW_03684	COG0745	RESPONSE REGULATOR receiver
XCAW_03687	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XCAW_03688	COG0697	spore germination
XCAW_03691	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XCAW_03693	COG3386	PFAM SMP-30 Gluconolaconase
XCAW_03697	COG1024	Enoyl-CoA hydratase
XCAW_03699	COG0318	PFAM AMP-dependent synthetase and ligase
XCAW_03700	COG0583	DNA-binding transcription factor activity
XCAW_03701	COG3384	dioxygenase
XCAW_03707	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCAW_03708	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XCAW_03710	COG2096	Adenosyltransferase
XCAW_03711	COG0123	including yeast histone deacetylase and acetoin utilization protein
XCAW_03714	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XCAW_03715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XCAW_03716	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XCAW_03717	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XCAW_03718	COG2967	ApaG domain
XCAW_03719	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XCAW_03723	COG0747	negative chemotaxis
XCAW_03727	COG0431	NADPH-dependent FMN reductase
XCAW_03728	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XCAW_03731	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XCAW_03732	COG1116	anion transmembrane transporter activity
XCAW_03734	COG3829	transcription factor binding
XCAW_03737	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XCAW_03738	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XCAW_03742	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XCAW_03744	COG0642	Histidine kinase
XCAW_03747	COG4181	ATPase activity
XCAW_03749	COG2175	clavaminate synthase activity
XCAW_03751	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XCAW_03752	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XCAW_03756	COG4771	TonB-dependent receptor
XCAW_03758	COG0667	Aldo Keto reductase
XCAW_03761	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XCAW_03762	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XCAW_03764	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XCAW_03765	COG4106	trans-aconitate 2-methyltransferase activity
XCAW_03767	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XCAW_03774	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XCAW_03776	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XCAW_03777	COG2226	methyltransferase
XCAW_03784	COG0366	Alpha amylase catalytic
XCAW_03788	COG3321	synthase
XCAW_03788	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_03788	COG0604	alcohol dehydrogenase
XCAW_03790	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XCAW_03792	COG0494	nUDIX hydrolase
XCAW_03793	COG0653	protein targeting
XCAW_03794	COG0739	heme binding
XCAW_03796	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XCAW_03799	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XCAW_03800	COG1181	Belongs to the D-alanine--D-alanine ligase family
XCAW_03801	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XCAW_03802	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XCAW_03804	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XCAW_03805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XCAW_03806	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XCAW_03808	COG3116	cell division
XCAW_03809	COG0275	rRNA processing
XCAW_03810	COG2001	Belongs to the MraZ family
XCAW_03817	COG0792	nuclease activity
XCAW_03818	COG1988	membrane-bound metal-dependent
XCAW_03819	COG0277	FAD linked oxidase domain protein
XCAW_03822	COG0745	RESPONSE REGULATOR receiver
XCAW_03823	COG2205	protein histidine kinase activity
XCAW_03824	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XCAW_03825	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XCAW_03826	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XCAW_03830	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XCAW_03831	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XCAW_03832	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XCAW_03836	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XCAW_03836	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XCAW_03838	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XCAW_03839	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XCAW_03841	COG0488	(ABC) transporter
XCAW_03843	COG0697	spore germination
XCAW_03845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XCAW_03847	COG3791	Glutathione-dependent formaldehyde-activating
XCAW_03852	COG0745	RESPONSE REGULATOR receiver
XCAW_03853	COG2205	protein histidine kinase activity
XCAW_03856	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XCAW_03857	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XCAW_03860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XCAW_03862	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XCAW_03863	COG1012	belongs to the aldehyde dehydrogenase family
XCAW_03864	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XCAW_03865	COG0617	tRNA 3'-terminal CCA addition
XCAW_03867	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XCAW_03868	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XCAW_03869	COG1609	Transcriptional regulator
XCAW_03874	COG3250	beta-galactosidase activity
XCAW_03884	COG1459	type II secretion system
XCAW_03895	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XCAW_03896	COG4191	Histidine kinase
XCAW_03897	COG0784	Response regulator, receiver
XCAW_03898	COG4251	negative regulation of phosphorylation
XCAW_03899	COG2823	Periplasmic or secreted lipoprotein
XCAW_03900	COG0673	inositol 2-dehydrogenase activity
XCAW_03901	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XCAW_03908	COG1056	cytidyltransferase-related domain
XCAW_03908	COG1051	belongs to the nudix hydrolase family
XCAW_03910	COG0583	DNA-binding transcription factor activity
XCAW_03913	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XCAW_03914	COG0321	lipoyl(octanoyl) transferase activity
XCAW_03915	COG2921	Belongs to the UPF0250 family
XCAW_03917	COG1686	Belongs to the peptidase S11 family
XCAW_03918	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XCAW_03919	COG2951	lytic endotransglycosylase activity
XCAW_03921	COG0772	Belongs to the SEDS family
XCAW_03924	COG1792	Involved in formation and maintenance of cell shape
XCAW_03925	COG1077	Cell shape determining protein MreB Mrl
XCAW_03927	COG3284	Transcriptional regulator
XCAW_03936	COG0308	aminopeptidase N
XCAW_03937	COG3300	MHYT domain
XCAW_03937	COG5001	Diguanylate cyclase
XCAW_03938	COG2226	methyltransferase
XCAW_03943	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XCAW_03944	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XCAW_03945	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XCAW_03947	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XCAW_03949	COG2832	Protein of unknown function (DUF454)
XCAW_03952	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XCAW_03953	COG1505	serine-type exopeptidase activity
XCAW_03959	COG0181	hydroxymethylbilane synthase activity
XCAW_03961	COG3275	phosphorelay sensor kinase activity
XCAW_03963	COG2943	transferase activity, transferring hexosyl groups
XCAW_03967	COG3706	GGDEF domain
XCAW_03968	COG0659	secondary active sulfate transmembrane transporter activity
XCAW_03969	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XCAW_03969	COG5297	Belongs to the glycosyl hydrolase family 6
XCAW_03970	COG0840	transmembrane signaling receptor activity
XCAW_03971	COG5001	Diguanylate cyclase
XCAW_03977	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XCAW_03979	COG0598	Magnesium transport protein CorA
XCAW_03981	COG1113	amino acid transport
XCAW_03986	COG0697	spore germination
XCAW_03992	COG3706	GGDEF domain
XCAW_03995	COG1506	peptidase
XCAW_03995	COG0823	Involved in the tonB-independent uptake of proteins
XCAW_03996	COG2409	Drug exporters of the RND superfamily
XCAW_04001	COG0435	Glutathione S-transferase
XCAW_04006	COG2003	Belongs to the UPF0758 family
XCAW_04012	COG0784	Response regulator, receiver
XCAW_04012	COG4191	Histidine kinase
XCAW_04019	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCAW_04021	COG2895	sulfate adenylyltransferase (ATP) activity
XCAW_04021	COG0529	Catalyzes the synthesis of activated sulfate
XCAW_04022	COG0175	sulfate reduction
XCAW_04023	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XCAW_04024	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XCAW_04025	COG0175	sulfate reduction
XCAW_04033	COG1648	precorrin-2 dehydrogenase activity
XCAW_04033	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XCAW_04036	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XCAW_04037	COG3588	fructose-bisphosphate aldolase
XCAW_04038	COG0469	pyruvate kinase activity
XCAW_04040	COG0126	phosphoglycerate kinase activity
XCAW_04044	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XCAW_04046	COG3047	cAMP biosynthetic process
XCAW_04047	COG3047	cAMP biosynthetic process
XCAW_04049	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XCAW_04049	COG3453	Protein conserved in bacteria
XCAW_04050	COG0725	ABC transporter, periplasmic molybdate-binding protein
XCAW_04051	COG4149	molybdate abc transporter
XCAW_04052	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XCAW_04059	COG1376	ErfK ybiS ycfS ynhG family protein
XCAW_04060	COG0739	heme binding
XCAW_04062	COG4773	Receptor
XCAW_04063	COG0596	Alpha beta hydrolase
XCAW_04064	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XCAW_04065	COG1301	dicarboxylic acid transport
XCAW_04067	COG2304	oxidoreductase activity
XCAW_04071	COG0714	Associated with various cellular activities
XCAW_04078	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XCAW_04081	COG0254	rRNA binding
XCAW_04083	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XCAW_04086	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XCAW_04087	COG1758	RNA polymerase activity
XCAW_04088	COG0194	GDP metabolic process
XCAW_04089	COG1561	YicC-like family, N-terminal region
XCAW_04090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XCAW_04092	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XCAW_04093	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XCAW_04096	COG0006	proline dipeptidase activity
XCAW_04098	COG0006	proline dipeptidase activity
XCAW_04099	COG3079	Belongs to the UPF0149 family
XCAW_04102	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XCAW_04104	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XCAW_04106	COG2912	Transglutaminase-like superfamily
XCAW_04107	COG1773	rubredoxin
XCAW_04108	COG0352	thiamine-phosphate diphosphorylase activity
XCAW_04113	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XCAW_04116	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XCAW_04122	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XCAW_04123	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XCAW_04124	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_04126	COG0671	phosphoesterase, PA-phosphatase related
XCAW_04127	COG3781	membrane
XCAW_04129	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XCAW_04131	COG0563	adenylate kinase activity
XCAW_04134	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XCAW_04136	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XCAW_04140	COG3710	Transcriptional regulator
XCAW_04141	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XCAW_04143	COG0840	transmembrane signaling receptor activity
XCAW_04144	COG0405	Gamma-glutamyltransferase
XCAW_04145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XCAW_04149	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XCAW_04150	COG0473	3-isopropylmalate dehydrogenase activity
XCAW_04151	COG0066	3-isopropylmalate dehydratase activity
XCAW_04152	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XCAW_04156	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XCAW_04157	COG1538	Outer membrane efflux protein
XCAW_04158	COG1519	Transferase
XCAW_04159	COG1560	Kdo2-lipid A biosynthetic process
XCAW_04165	COG0280	phosphate acetyltransferase
XCAW_04165	COG0281	malic enzyme
XCAW_04166	COG1301	dicarboxylic acid transport
XCAW_04171	COG0583	DNA-binding transcription factor activity
XCAW_04172	COG0667	Aldo Keto reductase
XCAW_04176	COG2197	response regulator
XCAW_04177	COG1840	ABC-type Fe3 transport system, periplasmic component
XCAW_04178	COG0642	Histidine kinase
XCAW_04181	COG2851	Citrate transporter
XCAW_04182	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_04183	COG1609	Transcriptional regulator
XCAW_04184	COG2211	Major facilitator Superfamily
XCAW_04190	COG1162	GTPase activity
XCAW_04195	COG4773	Receptor
XCAW_04196	COG0726	polysaccharide deacetylase
XCAW_04197	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XCAW_04200	COG2963	transposase activity
XCAW_04201	COG2801	Transposase and inactivated derivatives
XCAW_04206	COG1307	EDD domain protein, DegV family
XCAW_04208	COG0242	peptide deformylase activity
XCAW_04212	COG0457	Tetratricopeptide repeat
XCAW_04213	COG0457	Tetratricopeptide repeat
XCAW_04214	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XCAW_04215	COG1215	transferase activity, transferring glycosyl groups
XCAW_04216	COG1215	transferase activity, transferring glycosyl groups
XCAW_04219	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XCAW_04228	COG2188	Transcriptional regulator
XCAW_04231	COG1450	Type ii and iii secretion system protein
XCAW_04234	COG3166	PFAM Fimbrial assembly family protein
XCAW_04235	COG3156	type II secretion system protein K
XCAW_04236	COG4795	General secretion pathway protein
XCAW_04237	COG2165	general secretion pathway protein
XCAW_04238	COG4970	Tfp pilus assembly protein FimT
XCAW_04239	COG2165	general secretion pathway protein
XCAW_04240	COG1459	type II secretion system
XCAW_04241	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XCAW_04243	COG1404	Belongs to the peptidase S8 family
XCAW_04244	COG5295	Hep Hag repeat protein
XCAW_04245	COG1404	Belongs to the peptidase S8 family
XCAW_04246	COG5295	Hep Hag repeat protein
XCAW_04247	COG0047	phosphoribosylformylglycinamidine synthase activity
XCAW_04247	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XCAW_04248	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XCAW_04250	COG4974	Belongs to the 'phage' integrase family
XCAW_04253	COG0795	lipopolysaccharide-transporting ATPase activity
XCAW_04255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XCAW_04258	COG0525	valine-tRNA ligase activity
XCAW_04265	COG1183	phosphatidylcholine synthase activity
XCAW_04267	COG0442	prolyl-tRNA aminoacylation
XCAW_04270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XCAW_04271	COG1127	ABC transporter
XCAW_04272	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XCAW_04272	COG3218	ABC-type transport auxiliary lipoprotein component
XCAW_04279	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XCAW_04280	COG0662	Cupin 2, conserved barrel domain protein
XCAW_04280	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XCAW_04286	COG2086	electron transfer activity
XCAW_04289	COG0546	phosphoglycolate phosphatase activity
XCAW_04289	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XCAW_04290	COG0277	FAD linked oxidase domain protein
XCAW_04291	COG0300	oxidoreductase activity
XCAW_04293	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XCAW_04297	COG2226	methyltransferase
XCAW_04299	COG3754	Rhamnan synthesis protein F
XCAW_04301	COG0438	transferase activity, transferring glycosyl groups
XCAW_04301	COG1216	Glycosyl transferase, family 2
XCAW_04304	COG0626	cystathionine gamma-synthase activity
XCAW_04311	COG0625	glutathione transferase activity
XCAW_04313	COG0513	Belongs to the DEAD box helicase family
XCAW_04315	COG4771	TonB-dependent receptor
XCAW_04316	COG0720	synthase
XCAW_04318	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XCAW_04319	COG1956	GAF domain-containing protein
XCAW_04321	COG2819	hydrolase of the alpha beta superfamily
XCAW_04324	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XCAW_04325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XCAW_04328	COG0339	signal peptide processing
XCAW_04338	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XCAW_04339	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCAW_04340	COG4591	ABC-type transport system involved in lipoprotein release permease component
XCAW_04340	COG1136	(ABC) transporter
XCAW_04341	COG0577	efflux transmembrane transporter activity
XCAW_04342	COG0577	efflux transmembrane transporter activity
XCAW_04344	COG2204	response regulator
XCAW_04345	COG4191	Histidine kinase
XCAW_04346	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XCAW_04349	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XCAW_04350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XCAW_04352	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XCAW_04353	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XCAW_04354	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XCAW_04355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XCAW_04357	COG0356	it plays a direct role in the translocation of protons across the membrane
XCAW_04361	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XCAW_04371	COG2011	ABC-type metal ion transport system permease component
XCAW_04372	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XCAW_04373	COG0697	spore germination
XCAW_04374	COG1666	GTP binding
XCAW_04376	COG2198	Histidine kinase
XCAW_04376	COG5002	protein histidine kinase activity
XCAW_04376	COG0784	Response regulator, receiver
XCAW_04381	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XCAW_04382	COG1187	pseudouridine synthase activity
XCAW_04383	COG2813	Specifically methylates the guanine in position
XCAW_04387	COG2205	protein histidine kinase activity
XCAW_04387	COG2202	Pas domain
XCAW_04391	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XCAW_04392	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XCAW_04393	COG1522	sequence-specific DNA binding
XCAW_04403	COG0842	Transport permease protein
XCAW_04404	COG1131	(ABC) transporter
XCAW_04405	COG0025	NhaP-type Na H and K H
XCAW_04406	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XCAW_04407	COG1573	uracil-dna glycosylase
XCAW_04410	COG3384	dioxygenase
XCAW_04412	COG0583	DNA-binding transcription factor activity
XCAW_04414	COG0667	Aldo Keto reductase
XCAW_04416	COG3590	peptidase
XCAW_04420	COG0531	amino acid
XCAW_04423	COG2972	Histidine kinase
XCAW_04426	COG3685	Protein conserved in bacteria
XCAW_04427	COG3546	catalase activity
XCAW_04436	COG1271	oxidase subunit
XCAW_04437	COG1294	oxidase, subunit
XCAW_04440	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_04445	COG1132	(ABC) transporter
XCAW_04448	COG1063	alcohol dehydrogenase
XCAW_04463	COG0251	oxidation-reduction process
XCAW_04466	COG0840	transmembrane signaling receptor activity
XCAW_04469	COG0583	DNA-binding transcription factor activity
XCAW_04470	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XCAW_04479	COG0024	Methionine aminopeptidase
XCAW_04484	COG0431	NADPH-dependent FMN reductase
XCAW_04485	COG2963	transposase activity
XCAW_04486	COG2801	Transposase and inactivated derivatives
XCAW_04492	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XCAW_04500	COG4695	Portal protein
XCAW_04509	COG3179	chitinase
XCAW_04548	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XCAW_04549	COG1490	D-aminoacyl-tRNA deacylase activity
XCAW_04550	COG1560	Kdo2-lipid A biosynthetic process
XCAW_04559	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XCAW_04559	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XCAW_04560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XCAW_04561	COG0242	peptide deformylase activity
XCAW_04562	COG1652	LysM domain
XCAW_04563	COG0758	DNA mediated transformation
XCAW_04567	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XCAW_04567	COG1754	DNA topoisomerase type I activity
XCAW_04568	COG0009	L-threonylcarbamoyladenylate synthase
XCAW_04571	COG1028	Short-chain dehydrogenase reductase Sdr
XCAW_04573	COG0616	signal peptide processing
XCAW_04574	COG0534	Mate efflux family protein
XCAW_04578	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XCAW_04579	COG0625	glutathione transferase activity
XCAW_04582	COG1252	NADH dehydrogenase
XCAW_04583	COG2860	membrane
XCAW_04584	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XCAW_04585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XCAW_04586	COG2201	protein-glutamate methylesterase activity
XCAW_04587	COG2177	Part of the ABC transporter FtsEX involved in
XCAW_04588	COG2884	Cell division ATP-binding protein ftsE
XCAW_04589	COG0513	Belongs to the DEAD box helicase family
XCAW_04590	COG3118	belongs to the thioredoxin family
XCAW_04591	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XCAW_04592	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XCAW_04593	COG0583	DNA-binding transcription factor activity
XCAW_04603	COG1518	maintenance of DNA repeat elements
XCAW_04607	COG1652	LysM domain
XCAW_04608	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XCAW_04608	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XCAW_04609	COG1473	amidohydrolase
XCAW_04610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XCAW_04611	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XCAW_04613	COG5383	Protein conserved in bacteria
XCAW_04621	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XCAW_04622	COG3023	N-Acetylmuramoyl-L-alanine amidase
XCAW_04624	COG4948	Mandelate Racemase Muconate Lactonizing
XCAW_04626	COG0531	amino acid
XCAW_04629	COG4682	membrane
XCAW_04630	COG2133	pyrroloquinoline quinone binding
XCAW_04632	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XCAW_04633	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XCAW_04634	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XCAW_04635	COG1610	YqeY-like protein
XCAW_04636	COG1295	ribonuclease BN
XCAW_04637	COG0358	DNA primase activity
XCAW_04640	COG0109	protoheme IX farnesyltransferase activity
XCAW_04646	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XCAW_04649	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XCAW_04658	COG3135	benzoate transporter
XCAW_04662	COG0676	glucose-6-phosphate 1-epimerase activity
XCAW_04664	COG3012	SEC-C Motif Domain Protein
XCAW_04665	COG0730	response to heat
XCAW_04670	COG0302	gtp cyclohydrolase
XCAW_04673	COG1566	PFAM secretion protein HlyD family protein
XCAW_04676	COG1289	transmembrane transporter activity
XCAW_04677	COG0477	Major facilitator Superfamily
XCAW_04679	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XCAW_04683	COG4691	Plasmid stability protein
XCAW_04684	COG1487	ribonuclease activity
XCAW_04691	COG0564	pseudouridine synthase activity
XCAW_04693	COG2963	transposase activity
XCAW_04698	COG0439	Biotin carboxylase
XCAW_04708	COG1074	ATP-dependent DNA helicase activity
XCAW_04709	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XCAW_04711	COG1127	ABC transporter
XCAW_04712	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XCAW_04713	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XCAW_04716	COG2853	Lipoprotein
XCAW_04718	COG0386	Belongs to the glutathione peroxidase family
XCAW_04720	COG1322	Protein conserved in bacteria
XCAW_04721	COG0604	alcohol dehydrogenase
XCAW_04722	COG0583	DNA-binding transcription factor activity
XCAW_04724	COG0625	glutathione transferase activity
XCAW_04726	COG0531	amino acid
XCAW_04727	COG3537	Alpha-1,2-mannosidase
XCAW_04730	COG3706	GGDEF domain
XCAW_04731	COG3835	regulator
XCAW_04732	COG1929	Belongs to the glycerate kinase type-1 family
XCAW_04733	COG2271	Major facilitator Superfamily
XCAW_04736	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XCAW_04737	COG0861	Integral membrane protein TerC family
XCAW_04739	COG0584	glycerophosphoryl diester phosphodiesterase
XCAW_04742	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XCAW_04743	COG0726	polysaccharide deacetylase
XCAW_04744	COG0706	membrane insertase activity
XCAW_04745	COG0594	ribonuclease P activity
XCAW_04746	COG0230	Belongs to the bacterial ribosomal protein bL34 family
XCAW_a00005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCAW_a00013	COG3505	Type IV secretory pathway VirD4
XCAW_a00016	COG1487	ribonuclease activity
XCAW_b00001	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCAW_b00007	COG2963	transposase activity
XCAW_b00008	COG2801	Transposase and inactivated derivatives
XCAW_b00019	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCAW_b00024	COG2963	transposase activity
XCAW_b00029	COG2801	Transposase and inactivated derivatives
XCAW_b00030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XCAW_b00058	COG1674	ftsk spoiiie
XCAW_b00066	COG3012	SEC-C Motif Domain Protein
XCAW_b00066	COG3318	Belongs to the UPF0149 family