locus-tag	class	description
J158_00006	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J158_00036	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J158_00041	COG1192	Involved in chromosome partitioning
J158_00049	COG2951	lytic endotransglycosylase activity
J158_00050	COG4644	lycopene metabolic process
J158_00080	COG2948	multi-organism process
J158_00081	COG3504	Conjugal transfer protein
J158_00102	COG4456	Virulence-associated protein
J158_00103	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J158_00105	COG2801	Transposase and inactivated derivatives
J158_00110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J158_00111	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J158_00113	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J158_00115	COG0187	DNA topoisomerase II activity
J158_00117	COG0501	Belongs to the peptidase M48B family
J158_00123	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J158_00125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J158_00134	COG0793	Belongs to the peptidase S41A family
J158_00135	COG4942	peptidase
J158_00137	COG2234	aminopeptidase activity
J158_00139	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J158_00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J158_00141	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J158_00142	COG1064	alcohol dehydrogenase
J158_00143	COG0493	'glutamate synthase
J158_00144	COG0067	glutamate synthase
J158_00144	COG0070	glutamate synthase
J158_00144	COG0069	glutamate synthase activity
J158_00148	COG2366	antibiotic biosynthetic process
J158_00153	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J158_00156	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
J158_00157	COG0297	glycogen (starch) synthase activity
J158_00157	COG0438	transferase activity, transferring glycosyl groups
J158_00161	COG0367	asparagine synthase
J158_00167	COG1132	(ABC) transporter
J158_00191	COG1205	dead DEAH box helicase
J158_00191	COG1111	helicase
J158_00192	COG1272	protein, Hemolysin III
J158_00195	COG0300	oxidoreductase activity
J158_00196	COG1028	Short-chain dehydrogenase reductase Sdr
J158_00201	COG2249	NAD(P)H dehydrogenase (quinone) activity
J158_00203	COG2963	transposase activity
J158_00204	COG2801	Transposase and inactivated derivatives
J158_00212	COG3237	CsbD-like
J158_00221	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J158_00222	COG0477	Major facilitator Superfamily
J158_00230	COG0714	Associated with various cellular activities
J158_00236	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
J158_00238	COG4772	TonB-dependent receptor
J158_00240	COG0662	Cupin 2, conserved barrel domain protein
J158_00241	COG1012	belongs to the aldehyde dehydrogenase family
J158_00246	COG1304	FMN binding
J158_00248	COG4585	Histidine kinase
J158_00249	COG2197	response regulator
J158_00253	COG3710	Transcriptional regulator
J158_00254	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J158_00267	COG2963	transposase activity
J158_00269	COG0366	Alpha amylase catalytic
J158_00270	COG0366	Alpha amylase catalytic
J158_00271	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J158_00275	COG0657	acetylesterase activity
J158_00275	COG2755	lipolytic protein G-D-S-L family
J158_00277	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J158_00280	COG3507	Belongs to the glycosyl hydrolase 43 family
J158_00281	COG1609	Transcriptional regulator
J158_00282	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
J158_00283	COG1028	Short-chain dehydrogenase reductase Sdr
J158_00285	COG2755	lipolytic protein G-D-S-L family
J158_00288	COG3186	Phenylalanine-4-hydroxylase
J158_00289	COG1522	sequence-specific DNA binding
J158_00291	COG1752	Esterase of the alpha-beta hydrolase superfamily
J158_00293	COG1119	ATPase activity
J158_00296	COG1125	glycine betaine transport
J158_00299	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J158_00302	COG1396	sequence-specific DNA binding
J158_00306	COG0489	protein tyrosine kinase activity
J158_00307	COG2062	phosphohistidine phosphatase, SixA
J158_00309	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J158_00318	COG1968	undecaprenyl-diphosphatase activity
J158_00319	COG0174	glutamine synthetase
J158_00320	COG0347	Belongs to the P(II) protein family
J158_00321	COG0004	ammonium transporteR
J158_00322	COG3852	Histidine kinase
J158_00323	COG2204	response regulator
J158_00324	COG2032	superoxide dismutase activity
J158_00325	COG2032	superoxide dismutase activity
J158_00326	COG0346	lactoylglutathione lyase activity
J158_00328	COG0183	Belongs to the thiolase family
J158_00335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J158_00336	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
J158_00337	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J158_00339	COG0028	Belongs to the TPP enzyme family
J158_00340	COG2205	protein histidine kinase activity
J158_00345	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J158_00348	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J158_00350	COG0596	Alpha beta hydrolase
J158_00352	COG0318	PFAM AMP-dependent synthetase and ligase
J158_00354	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J158_00356	COG1181	Belongs to the D-alanine--D-alanine ligase family
J158_00358	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J158_00360	COG0564	pseudouridine synthase activity
J158_00365	COG0339	signal peptide processing
J158_00370	COG0475	glutathione-regulated potassium exporter activity
J158_00371	COG0583	DNA-binding transcription factor activity
J158_00372	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J158_00373	COG2224	Isocitrate lyase
J158_00374	COG3706	GGDEF domain
J158_00380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J158_00381	COG1960	acyl-CoA dehydrogenase activity
J158_00392	COG0523	cobalamin synthesis protein
J158_00394	COG0697	spore germination
J158_00396	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J158_00397	COG1846	Transcriptional regulator
J158_00398	COG1764	response to oxidative stress
J158_00403	COG2130	NADP-dependent
J158_00406	COG1187	pseudouridine synthase activity
J158_00409	COG1643	Atp-dependent helicase
J158_00410	COG4807	Protein conserved in bacteria
J158_00411	COG2351	hydroxyisourate hydrolase activity
J158_00412	COG2072	flavoprotein involved in K transport
J158_00416	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J158_00423	COG1957	nucleoside hydrolase
J158_00425	COG2252	PERMEase
J158_00429	COG0084	hydrolase, TatD family'
J158_00432	COG0583	DNA-binding transcription factor activity
J158_00433	COG2814	Major facilitator Superfamily
J158_00436	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J158_00437	COG1902	pentaerythritol trinitrate reductase activity
J158_00441	COG0745	RESPONSE REGULATOR receiver
J158_00442	COG2205	protein histidine kinase activity
J158_00443	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J158_00445	COG1538	Outer membrane efflux protein
J158_00447	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J158_00448	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J158_00449	COG0583	DNA-binding transcription factor activity
J158_00455	COG0702	epimerase
J158_00456	COG1733	regulation of RNA biosynthetic process
J158_00461	COG2963	transposase activity
J158_00463	COG0129	dihydroxy-acid dehydratase activity
J158_00466	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
J158_00477	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J158_00478	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J158_00483	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J158_00484	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J158_00486	COG3485	protocatechuate 3,4-dioxygenase
J158_00487	COG3485	protocatechuate 3,4-dioxygenase
J158_00489	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J158_00490	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J158_00492	COG1414	Transcriptional regulator
J158_00496	COG0445	tRNA wobble uridine modification
J158_00504	COG2267	carboxylic ester hydrolase activity
J158_00506	COG0156	8-amino-7-oxononanoate synthase activity
J158_00507	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J158_00508	COG1040	competence protein
J158_00509	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J158_00526	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J158_00540	COG3264	Mechanosensitive ion channel
J158_00540	COG1511	domain protein
J158_00541	COG1368	sulfuric ester hydrolase activity
J158_00542	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J158_00543	COG2354	Protein conserved in bacteria
J158_00544	COG0745	RESPONSE REGULATOR receiver
J158_00544	COG3706	GGDEF domain
J158_00545	COG0297	glycogen (starch) synthase activity
J158_00546	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J158_00547	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J158_00552	COG0702	epimerase
J158_00553	COG1028	Short-chain dehydrogenase reductase Sdr
J158_00559	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J158_00560	COG1028	Short-chain dehydrogenase reductase Sdr
J158_00562	COG0513	Belongs to the DEAD box helicase family
J158_00567	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J158_00569	COG3483	tryptophan 2,3-dioxygenase activity
J158_00570	COG3104	oligopeptide transport
J158_00574	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
J158_00577	COG1320	monovalent cation:proton antiporter activity
J158_00578	COG2212	antiporter activity
J158_00580	COG0651	ATP synthesis coupled electron transport
J158_00581	COG1006	Multisubunit Na H antiporter MnhC subunit
J158_00582	COG2111	Na H antiporter
J158_00582	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J158_00586	COG3179	chitinase
J158_00590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J158_00591	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J158_00594	COG0456	acetyltransferase
J158_00595	COG1597	lipid kinase activity
J158_00600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J158_00601	COG0134	indole-3-glycerol-phosphate synthase activity
J158_00603	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J158_00604	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
J158_00606	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
J158_00607	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J158_00608	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J158_00611	COG1051	belongs to the nudix hydrolase family
J158_00618	COG0316	Belongs to the HesB IscA family
J158_00622	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J158_00625	COG2814	Major facilitator Superfamily
J158_00626	COG0583	DNA-binding transcription factor activity
J158_00627	COG2814	Major facilitator Superfamily
J158_00628	COG1289	transmembrane transporter activity
J158_00629	COG0151	Belongs to the GarS family
J158_00631	COG0138	bifunctional purine biosynthesis protein purh
J158_00632	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J158_00633	COG2267	carboxylic ester hydrolase activity
J158_00634	COG2453	phosphatase
J158_00634	COG0671	phosphoesterase, PA-phosphatase related
J158_00639	COG4589	Belongs to the CDS family
J158_00640	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
J158_00645	COG2264	protein methyltransferase activity
J158_00648	COG0439	Biotin carboxylase
J158_00650	COG0511	ligase activity, forming carbon-carbon bonds
J158_00651	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J158_00653	COG1324	tolerance protein
J158_00658	COG0300	oxidoreductase activity
J158_00659	COG2356	endonuclease I
J158_00660	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J158_00661	COG0459	protein refolding
J158_00664	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J158_00667	COG3386	PFAM SMP-30 Gluconolaconase
J158_00669	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J158_00670	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J158_00673	COG0778	Nitroreductase
J158_00674	COG2353	YceI-like domain
J158_00679	COG3052	prosthetic group binding
J158_00683	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
J158_00685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J158_00687	COG1802	Transcriptional regulator
J158_00697	COG2963	transposase activity
J158_00698	COG4221	oxidoreductase activity
J158_00701	COG4221	oxidoreductase activity
J158_00703	COG0435	Glutathione S-transferase
J158_00708	COG2409	Drug exporters of the RND superfamily
J158_00709	COG0823	Involved in the tonB-independent uptake of proteins
J158_00709	COG1506	peptidase
J158_00711	COG3706	GGDEF domain
J158_00715	COG0697	spore germination
J158_00719	COG1113	amino acid transport
J158_00721	COG0598	Magnesium transport protein CorA
J158_00723	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
J158_00730	COG5001	Diguanylate cyclase
J158_00731	COG0840	transmembrane signaling receptor activity
J158_00732	COG5297	Belongs to the glycosyl hydrolase family 6
J158_00732	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J158_00733	COG0659	secondary active sulfate transmembrane transporter activity
J158_00734	COG3706	GGDEF domain
J158_00737	COG2943	transferase activity, transferring hexosyl groups
J158_00739	COG3275	phosphorelay sensor kinase activity
J158_00741	COG0181	hydroxymethylbilane synthase activity
J158_00746	COG1505	serine-type exopeptidase activity
J158_00747	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J158_00750	COG2832	Protein of unknown function (DUF454)
J158_00752	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J158_00754	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J158_00755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
J158_00756	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J158_00761	COG2226	methyltransferase
J158_00762	COG5001	Diguanylate cyclase
J158_00762	COG3300	MHYT domain
J158_00763	COG0308	aminopeptidase N
J158_00772	COG3284	Transcriptional regulator
J158_00774	COG1077	Cell shape determining protein MreB Mrl
J158_00775	COG1792	Involved in formation and maintenance of cell shape
J158_00778	COG0772	Belongs to the SEDS family
J158_00780	COG2951	lytic endotransglycosylase activity
J158_00781	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J158_00782	COG1686	Belongs to the peptidase S11 family
J158_00784	COG2921	Belongs to the UPF0250 family
J158_00785	COG0321	lipoyl(octanoyl) transferase activity
J158_00786	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J158_00789	COG0583	DNA-binding transcription factor activity
J158_00791	COG1051	belongs to the nudix hydrolase family
J158_00791	COG1056	cytidyltransferase-related domain
J158_00798	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J158_00799	COG0673	inositol 2-dehydrogenase activity
J158_00800	COG2823	Periplasmic or secreted lipoprotein
J158_00801	COG4251	negative regulation of phosphorylation
J158_00802	COG0784	Response regulator, receiver
J158_00803	COG4191	Histidine kinase
J158_00804	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J158_00815	COG1459	type II secretion system
J158_00826	COG3250	beta-galactosidase activity
J158_00832	COG1609	Transcriptional regulator
J158_00833	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J158_00834	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J158_00836	COG0617	tRNA 3'-terminal CCA addition
J158_00837	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
J158_00838	COG1012	belongs to the aldehyde dehydrogenase family
J158_00839	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J158_00841	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J158_00845	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J158_00846	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J158_00849	COG2205	protein histidine kinase activity
J158_00850	COG0745	RESPONSE REGULATOR receiver
J158_00855	COG3791	Glutathione-dependent formaldehyde-activating
J158_00857	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J158_00859	COG0697	spore germination
J158_00861	COG0488	(ABC) transporter
J158_00863	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J158_00864	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J158_00866	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J158_00866	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J158_00871	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J158_00872	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J158_00873	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J158_00877	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
J158_00878	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
J158_00879	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
J158_00880	COG2205	protein histidine kinase activity
J158_00881	COG0745	RESPONSE REGULATOR receiver
J158_00884	COG0277	FAD linked oxidase domain protein
J158_00885	COG1988	membrane-bound metal-dependent
J158_00886	COG0792	nuclease activity
J158_00893	COG2001	Belongs to the MraZ family
J158_00894	COG0275	rRNA processing
J158_00895	COG3116	cell division
J158_00897	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J158_00898	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J158_00899	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J158_00901	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J158_00902	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J158_00903	COG1181	Belongs to the D-alanine--D-alanine ligase family
J158_00904	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J158_00907	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J158_00909	COG0739	heme binding
J158_00910	COG0653	protein targeting
J158_00911	COG0494	nUDIX hydrolase
J158_00913	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J158_00916	COG1028	Short-chain dehydrogenase reductase Sdr
J158_00916	COG3321	synthase
J158_00916	COG0604	alcohol dehydrogenase
J158_00920	COG0366	Alpha amylase catalytic
J158_00926	COG2226	methyltransferase
J158_00927	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J158_00930	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J158_00936	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J158_00938	COG4106	trans-aconitate 2-methyltransferase activity
J158_00939	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J158_00942	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J158_00943	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J158_00944	COG0667	Aldo Keto reductase
J158_00946	COG4771	TonB-dependent receptor
J158_00951	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J158_00952	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
J158_00954	COG2175	clavaminate synthase activity
J158_00956	COG4181	ATPase activity
J158_00959	COG0642	Histidine kinase
J158_00961	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J158_00965	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J158_00966	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J158_00969	COG3829	transcription factor binding
J158_00971	COG1116	anion transmembrane transporter activity
J158_00972	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J158_00974	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J158_00975	COG0431	NADPH-dependent FMN reductase
J158_00980	COG0747	negative chemotaxis
J158_00985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J158_00986	COG2967	ApaG domain
J158_00987	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J158_00988	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J158_00989	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J158_00990	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
J158_00993	COG0123	including yeast histone deacetylase and acetoin utilization protein
J158_00994	COG2096	Adenosyltransferase
J158_00996	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J158_00997	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J158_01003	COG3384	dioxygenase
J158_01004	COG0583	DNA-binding transcription factor activity
J158_01007	COG1024	Enoyl-CoA hydratase
J158_01011	COG3386	PFAM SMP-30 Gluconolaconase
J158_01013	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
J158_01016	COG0697	spore germination
J158_01017	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J158_01020	COG3706	GGDEF domain
J158_01020	COG0745	RESPONSE REGULATOR receiver
J158_01021	COG2205	protein histidine kinase activity
J158_01021	COG0784	Response regulator, receiver
J158_01021	COG5002	protein histidine kinase activity
J158_01022	COG2197	response regulator
J158_01024	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J158_01026	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J158_01027	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J158_01028	COG0583	DNA-binding transcription factor activity
J158_01029	COG3634	alkyl hydroperoxide reductase activity
J158_01031	COG2890	protein-(glutamine-N5) methyltransferase activity
J158_01035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J158_01035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J158_01041	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J158_01046	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J158_01047	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
J158_01050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J158_01051	COG1404	Belongs to the peptidase S8 family
J158_01052	COG1404	Belongs to the peptidase S8 family
J158_01053	COG1404	Belongs to the peptidase S8 family
J158_01054	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J158_01060	COG1295	ribonuclease BN
J158_01061	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J158_01062	COG1254	Belongs to the acylphosphatase family
J158_01065	COG0521	Mo-molybdopterin cofactor biosynthetic process
J158_01067	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J158_01068	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J158_01070	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J158_01071	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J158_01073	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J158_01074	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J158_01075	COG0193	aminoacyl-tRNA hydrolase activity
J158_01076	COG0012	GTP binding
J158_01080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J158_01082	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J158_01083	COG0250	Participates in transcription elongation, termination and antitermination
J158_01084	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J158_01085	COG0081	regulation of translation
J158_01086	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J158_01087	COG0222	ribosome binding
J158_01089	COG0085	RNA polymerase activity
J158_01090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J158_01091	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J158_01092	COG0049	tRNA binding
J158_01093	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J158_01094	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J158_01095	COG0051	transcription antitermination factor activity, RNA binding
J158_01096	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J158_01097	COG0088	Forms part of the polypeptide exit tunnel
J158_01098	COG0089	rRNA binding
J158_01099	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J158_01100	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J158_01101	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J158_01102	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J158_01103	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J158_01104	COG0255	Belongs to the universal ribosomal protein uL29 family
J158_01105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J158_01106	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J158_01107	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J158_01108	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J158_01109	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J158_01110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J158_01111	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J158_01112	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J158_01113	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J158_01114	COG1841	ribosomal large subunit assembly
J158_01115	COG0200	Binds to the 23S rRNA
J158_01116	COG0201	protein transport
J158_01117	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J158_01118	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J158_01119	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J158_01120	COG0202	RNA polymerase activity
J158_01121	COG0203	ribosomal protein L17
J158_01122	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J158_01124	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J158_01126	COG0154	amidase activity
J158_01129	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J158_01130	COG0039	L-malate dehydrogenase activity
J158_01131	COG0625	glutathione transferase activity
J158_01133	COG1902	pentaerythritol trinitrate reductase activity
J158_01133	COG0446	pyridine nucleotide-disulphide oxidoreductase
J158_01134	COG0604	alcohol dehydrogenase
J158_01139	COG0156	8-amino-7-oxononanoate synthase activity
J158_01140	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
J158_01141	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
J158_01142	COG4208	sulfate ABC transporter
J158_01143	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J158_01145	COG1063	alcohol dehydrogenase
J158_01150	COG0406	alpha-ribazole phosphatase activity
J158_01151	COG0285	dihydrofolate synthase activity
J158_01155	COG2833	Protein of unknown function (DUF455)
J158_01157	COG3291	Pkd domain containing protein
J158_01159	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J158_01161	COG0671	phosphoesterase, PA-phosphatase related
J158_01162	COG0438	transferase activity, transferring glycosyl groups
J158_01164	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J158_01167	COG4783	chaperone-mediated protein folding
J158_01170	COG0473	3-isopropylmalate dehydrogenase activity
J158_01176	COG2801	Transposase and inactivated derivatives
J158_01177	COG2963	transposase activity
J158_01200	COG2963	transposase activity
J158_01204	COG3852	Histidine kinase
J158_01207	COG0544	peptidyl-prolyl cis-trans isomerase activity
J158_01208	COG0740	serine-type endopeptidase activity
J158_01209	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J158_01215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J158_01218	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J158_01220	COG0328	RNA-DNA hybrid ribonuclease activity
J158_01221	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J158_01222	COG0631	protein serine/threonine phosphatase activity
J158_01225	COG0859	PFAM glycosyl transferase family 9
J158_01226	COG3642	lipopolysaccharide core region biosynthetic process
J158_01227	COG1234	tRNA 3'-trailer cleavage
J158_01228	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J158_01229	COG0315	cyclic pyranopterin monophosphate synthase activity
J158_01230	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J158_01231	COG0314	molybdopterin synthase activity
J158_01234	COG2963	transposase activity
J158_01235	COG2801	Transposase and inactivated derivatives
J158_01242	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J158_01243	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J158_01244	COG0537	adenosine 5'-monophosphoramidase activity
J158_01248	COG0714	Associated with various cellular activities
J158_01252	COG0424	maF-like protein
J158_01253	COG1399	metal-binding, possibly nucleic acid-binding protein
J158_01254	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J158_01255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J158_01258	COG1028	Short-chain dehydrogenase reductase Sdr
J158_01259	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J158_01261	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J158_01262	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J158_01267	COG3829	transcription factor binding
J158_01271	COG3609	addiction module antidote protein, CC2985 family
J158_01276	COG2373	Large extracellular alpha-helical protein
J158_01279	COG4953	penicillin-binding protein 1C
J158_01281	COG0678	peroxiredoxin activity
J158_01287	COG0330	HflC and HflK could
J158_01288	COG0330	HflC and HflK could
J158_01290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J158_01291	COG0308	aminopeptidase N
J158_01293	COG1028	Short-chain dehydrogenase reductase Sdr
J158_01294	COG1309	transcriptional regulator
J158_01307	COG0328	RNA-DNA hybrid ribonuclease activity
J158_01307	COG0406	alpha-ribazole phosphatase activity
J158_01308	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J158_01310	COG3387	PFAM Glycoside hydrolase 15-related
J158_01311	COG1028	Short-chain dehydrogenase reductase Sdr
J158_01312	COG3537	Alpha-1,2-mannosidase
J158_01316	COG0492	ferredoxin-NADP+ reductase activity
J158_01321	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J158_01322	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J158_01323	COG2080	2 iron, 2 sulfur cluster binding
J158_01330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J158_01333	COG0587	DNA-directed DNA polymerase activity
J158_01336	COG1297	OPT oligopeptide transporter protein
J158_01339	COG0823	Involved in the tonB-independent uptake of proteins
J158_01339	COG1506	peptidase
J158_01342	COG1917	Cupin 2, conserved barrel domain protein
J158_01342	COG2207	Transcriptional regulator
J158_01347	COG0753	catalase activity
J158_01348	COG0656	L-ascorbic acid biosynthetic process
J158_01350	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J158_01350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J158_01353	COG2814	Major facilitator Superfamily
J158_01356	COG2194	sulfuric ester hydrolase activity
J158_01359	COG0745	RESPONSE REGULATOR receiver
J158_01360	COG0642	Histidine kinase
J158_01362	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
J158_01363	COG2894	cell division
J158_01364	COG0850	regulation of cytokinetic process
J158_01366	COG4585	Histidine kinase
J158_01367	COG2197	response regulator
J158_01370	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
J158_01375	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
J158_01377	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
J158_01382	COG1946	Acyl-CoA thioesterase
J158_01385	COG0824	Thioesterase
J158_01386	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J158_01387	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J158_01388	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J158_01389	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J158_01390	COG0268	Binds directly to 16S ribosomal RNA
J158_01392	COG0196	riboflavin kinase activity
J158_01393	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J158_01394	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J158_01395	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J158_01398	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J158_01399	COG1845	cytochrome c oxidase, subunit III
J158_01400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
J158_01403	COG3152	Membrane
J158_01405	COG2207	Transcriptional regulator
J158_01406	COG0326	Molecular chaperone. Has ATPase activity
J158_01408	COG1366	Belongs to the anti-sigma-factor antagonist family
J158_01409	COG1366	Belongs to the anti-sigma-factor antagonist family
J158_01410	COG2172	sigma factor antagonist activity
J158_01415	COG4771	TonB-dependent receptor
J158_01417	COG5507	3-demethylubiquinone-9 3-methyltransferase
J158_01418	COG2205	protein histidine kinase activity
J158_01420	COG4999	Histidine kinase
J158_01420	COG3437	response regulator, receiver
J158_01420	COG3850	Histidine kinase
J158_01420	COG2205	protein histidine kinase activity
J158_01421	COG0784	Response regulator, receiver
J158_01421	COG4191	Histidine kinase
J158_01426	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J158_01427	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J158_01429	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J158_01430	COG0228	four-way junction DNA binding
J158_01431	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J158_01432	COG0336	Belongs to the RNA methyltransferase TrmD family
J158_01433	COG0335	large ribosomal subunit rRNA binding
J158_01434	COG0534	Mate efflux family protein
J158_01435	COG0534	Mate efflux family protein
J158_01439	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
J158_01441	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J158_01444	COG3209	COG3209 Rhs family protein
J158_01448	COG3250	beta-galactosidase activity
J158_01449	COG3867	Arabinogalactan endo-beta-1,4-galactanase
J158_01453	COG1960	acyl-CoA dehydrogenase activity
J158_01454	COG1024	Enoyl-CoA hydratase
J158_01458	COG1250	3-hydroxyacyl-CoA dehydrogenase
J158_01458	COG1024	Enoyl-CoA hydratase
J158_01461	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J158_01462	COG0481	GTPase activity
J158_01465	COG0571	ribonuclease III activity
J158_01466	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J158_01467	COG1381	Involved in DNA repair and RecF pathway recombination
J158_01469	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J158_01471	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J158_01472	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
J158_01473	COG3046	protein related to deoxyribodipyrimidine photolyase
J158_01474	COG1472	Belongs to the glycosyl hydrolase 3 family
J158_01476	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J158_01477	COG1278	Cold shock
J158_01478	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J158_01480	COG1201	RNA secondary structure unwinding
J158_01481	COG1793	dna ligase
J158_01483	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J158_01483	COG1793	dna ligase
J158_01486	COG0745	RESPONSE REGULATOR receiver
J158_01486	COG3706	GGDEF domain
J158_01489	COG0183	Belongs to the thiolase family
J158_01493	COG1451	nucleotide metabolic process
J158_01494	COG5487	UPF0391 membrane protein
J158_01496	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J158_01499	COG1077	Cell shape determining protein MreB Mrl
J158_01500	COG1047	Peptidyl-prolyl cis-trans
J158_01502	COG2824	Alkylphosphonate utilization operon protein PhnA
J158_01503	COG1902	pentaerythritol trinitrate reductase activity
J158_01504	COG2814	Major facilitator Superfamily
J158_01511	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J158_01511	COG0392	lysyltransferase activity
J158_01514	COG0251	oxidation-reduction process
J158_01515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J158_01518	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J158_01523	COG1595	DNA-templated transcription, initiation
J158_01526	COG2878	Part of a membrane complex involved in electron transport
J158_01528	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J158_01528	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J158_01531	COG1131	(ABC) transporter
J158_01532	COG0346	lactoylglutathione lyase activity
J158_01533	COG0833	amino acid
J158_01534	COG2040	homocysteine
J158_01536	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J158_01540	COG1695	Transcriptional regulator
J158_01547	COG0825	malonyl-CoA metabolic process
J158_01549	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J158_01550	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J158_01551	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J158_01552	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J158_01553	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J158_01556	COG0750	zinc metalloprotease
J158_01557	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J158_01558	COG0575	Belongs to the CDS family
J158_01559	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J158_01560	COG0233	cytoplasmic translational termination
J158_01561	COG0528	UMP kinase activity
J158_01562	COG0745	RESPONSE REGULATOR receiver
J158_01562	COG3706	GGDEF domain
J158_01563	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J158_01564	COG0052	Belongs to the universal ribosomal protein uS2 family
J158_01571	COG0024	Methionine aminopeptidase
J158_01572	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
J158_01574	COG1393	Belongs to the ArsC family
J158_01575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J158_01576	COG0367	asparagine synthase
J158_01578	COG4774	siderophore transport
J158_01582	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J158_01588	COG1566	PFAM secretion protein HlyD family protein
J158_01589	COG2814	Major facilitator Superfamily
J158_01593	COG3104	oligopeptide transport
J158_01599	COG0339	signal peptide processing
J158_01600	COG0386	Belongs to the glutathione peroxidase family
J158_01611	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J158_01612	COG0084	hydrolase, TatD family'
J158_01615	COG1960	acyl-CoA dehydrogenase activity
J158_01618	COG0367	asparagine synthase
J158_01620	COG0305	Participates in initiation and elongation during chromosome replication
J158_01621	COG0415	Belongs to the DNA photolyase family
J158_01624	COG0583	DNA-binding transcription factor activity
J158_01631	COG3706	GGDEF domain
J158_01633	COG3706	GGDEF domain
J158_01660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J158_01663	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J158_01665	COG0497	DNA recombination
J158_01666	COG1420	regulation of RNA biosynthetic process
J158_01667	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J158_01668	COG0443	Heat shock 70 kDa protein
J158_01669	COG0484	heat shock protein binding
J158_01671	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
J158_01677	COG0583	DNA-binding transcription factor activity
J158_01678	COG1132	(ABC) transporter
J158_01685	COG2850	peptidyl-arginine hydroxylation
J158_01689	COG1253	flavin adenine dinucleotide binding
J158_01695	COG1131	(ABC) transporter
J158_01696	COG1725	Transcriptional regulator
J158_01698	COG0386	Belongs to the glutathione peroxidase family
J158_01701	COG2900	Belongs to the SlyX family
J158_01706	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J158_01708	COG0646	methionine synthase
J158_01708	COG1410	methionine synthase
J158_01709	COG0646	methionine synthase
J158_01709	COG1410	methionine synthase
J158_01711	COG1960	acyl-CoA dehydrogenase activity
J158_01714	COG0557	exoribonuclease II activity
J158_01716	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J158_01717	COG3706	GGDEF domain
J158_01718	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J158_01720	COG0704	Plays a role in the regulation of phosphate uptake
J158_01721	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J158_01722	COG0581	inorganic phosphate transmembrane transporter activity
J158_01723	COG0573	inorganic phosphate transmembrane transporter activity
J158_01724	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J158_01729	COG0659	secondary active sulfate transmembrane transporter activity
J158_01730	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J158_01732	COG1024	Enoyl-CoA hydratase
J158_01734	COG0494	nUDIX hydrolase
J158_01742	COG0116	Belongs to the methyltransferase superfamily
J158_01742	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J158_01743	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J158_01747	COG2925	Exonuclease
J158_01748	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J158_01749	COG3844	kynureninase activity
J158_01751	COG0662	Cupin 2, conserved barrel domain protein
J158_01752	COG0288	reversible hydration of carbon dioxide
J158_01764	COG2808	Putative FMN-binding domain
J158_01768	COG0017	Asparaginyl-tRNA synthetase
J158_01769	COG0316	Belongs to the HesB IscA family
J158_01770	COG0360	Binds together with S18 to 16S ribosomal RNA
J158_01771	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J158_01772	COG0359	binds to the 23S rRNA
J158_01774	COG3115	cell septum assembly
J158_01776	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J158_01777	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J158_01778	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
J158_01780	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
J158_01782	COG4993	Dehydrogenase
J158_01784	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J158_01786	COG2986	histidine ammonia-lyase
J158_01787	COG1228	amidohydrolase
J158_01795	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
J158_01796	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J158_01797	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J158_01798	COG0077	Prephenate dehydratase
J158_01798	COG1605	Chorismate mutase
J158_01799	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J158_01802	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J158_01803	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J158_01804	COG0583	DNA-binding transcription factor activity
J158_01807	COG0840	transmembrane signaling receptor activity
J158_01811	COG0745	RESPONSE REGULATOR receiver
J158_01812	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
J158_01813	COG0784	Response regulator, receiver
J158_01813	COG4191	Histidine kinase
J158_01816	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J158_01818	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J158_01820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J158_01823	COG1595	DNA-templated transcription, initiation
J158_01834	COG2244	polysaccharide biosynthetic process
J158_01840	COG2264	protein methyltransferase activity
J158_01842	COG0438	transferase activity, transferring glycosyl groups
J158_01845	COG1136	(ABC) transporter
J158_01847	COG0477	Major facilitator Superfamily
J158_01848	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J158_01851	COG1253	flavin adenine dinucleotide binding
J158_01853	COG0306	phosphate transporter
J158_01858	COG0504	CTP synthase activity
J158_01859	COG2877	3-deoxy-8-phosphooctulonate synthase activity
J158_01861	COG0148	phosphopyruvate hydratase activity
J158_01862	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
J158_01863	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J158_01864	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J158_01865	COG0585	pseudouridine synthase activity
J158_01866	COG2840	Smr protein MutS2
J158_01867	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J158_01868	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J158_01869	COG1238	metal cluster binding
J158_01873	COG1534	Rna-binding protein
J158_01874	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
J158_01875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J158_01876	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J158_01877	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J158_01878	COG1923	regulation of RNA biosynthetic process
J158_01879	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J158_01880	COG1546	Belongs to the CinA family
J158_01882	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J158_01883	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J158_01884	COG2137	regulation of response to DNA damage stimulus
J158_01885	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J158_01886	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
J158_01889	COG1741	Belongs to the pirin family
J158_01890	COG0583	DNA-binding transcription factor activity
J158_01895	COG0351	phosphomethylpyrimidine kinase
J158_01895	COG0352	thiamine-phosphate diphosphorylase activity
J158_01898	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J158_01899	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J158_01902	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J158_01904	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J158_01905	COG3734	2-keto-3-deoxy-galactonokinase
J158_01907	COG4948	Mandelate Racemase Muconate Lactonizing
J158_01908	COG0800	Aldolase
J158_01916	COG1501	Belongs to the glycosyl hydrolase 31 family
J158_01918	COG1070	Carbohydrate kinase
J158_01919	COG2115	Belongs to the xylose isomerase family
J158_01920	COG0477	Major facilitator Superfamily
J158_01923	COG0860	N-Acetylmuramoyl-L-alanine amidase
J158_01924	COG1469	GTP cyclohydrolase I activity
J158_01930	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J158_01931	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J158_01932	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J158_01933	COG0166	Belongs to the GPI family
J158_01937	COG1472	Belongs to the glycosyl hydrolase 3 family
J158_01939	COG2203	Gaf domain
J158_01939	COG3706	GGDEF domain
J158_01939	COG4251	negative regulation of phosphorylation
J158_01939	COG5001	Diguanylate cyclase
J158_01940	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J158_01941	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
J158_01943	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J158_01944	COG0671	phosphoesterase, PA-phosphatase related
J158_01946	COG1794	racemase activity, acting on amino acids and derivatives
J158_01947	COG0697	spore germination
J158_01948	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J158_01949	COG0167	dihydroorotate dehydrogenase activity
J158_01952	COG1012	belongs to the aldehyde dehydrogenase family
J158_01955	COG1215	transferase activity, transferring glycosyl groups
J158_01956	COG1649	PFAM Uncharacterised BCR, COG1649
J158_01956	COG0726	polysaccharide deacetylase
J158_01959	COG3210	domain, Protein
J158_01960	COG3210	domain, Protein
J158_01969	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J158_01970	COG0124	histidyl-tRNA synthetase
J158_01972	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J158_01973	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J158_01974	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J158_01975	COG0131	Imidazoleglycerol-phosphate dehydratase
J158_01975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J158_01976	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J158_01977	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J158_01978	COG0107	imidazoleglycerol-phosphate synthase activity
J158_01979	COG0140	phosphoribosyl-ATP diphosphatase activity
J158_01979	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J158_01982	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
J158_01983	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
J158_01984	COG0235	Class ii aldolase
J158_01985	COG0531	amino acid
J158_01986	COG0531	amino acid
J158_01988	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J158_01989	COG0277	FAD linked oxidase domain protein
J158_01993	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J158_02002	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J158_02003	COG2258	MOSC domain
J158_02004	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J158_02005	COG0505	Belongs to the CarA family
J158_02007	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J158_02008	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J158_02010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J158_02018	COG3279	Response regulator of the LytR AlgR family
J158_02019	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J158_02020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J158_02022	COG0784	Response regulator, receiver
J158_02022	COG2205	protein histidine kinase activity
J158_02022	COG2198	Histidine kinase
J158_02023	COG1024	Enoyl-CoA hydratase
J158_02024	COG0318	PFAM AMP-dependent synthetase and ligase
J158_02030	COG2267	carboxylic ester hydrolase activity
J158_02032	COG2201	protein-glutamate methylesterase activity
J158_02033	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
J158_02035	COG0840	transmembrane signaling receptor activity
J158_02036	COG0840	transmembrane signaling receptor activity
J158_02037	COG0840	transmembrane signaling receptor activity
J158_02038	COG0840	transmembrane signaling receptor activity
J158_02039	COG0840	transmembrane signaling receptor activity
J158_02040	COG0840	transmembrane signaling receptor activity
J158_02041	COG0840	transmembrane signaling receptor activity
J158_02044	COG0840	transmembrane signaling receptor activity
J158_02045	COG0840	transmembrane signaling receptor activity
J158_02045	COG0840	transmembrane signaling receptor activity
J158_02047	COG0840	transmembrane signaling receptor activity
J158_02048	COG0643	Histidine kinase
J158_02048	COG2198	Histidine kinase
J158_02049	COG0745	RESPONSE REGULATOR receiver
J158_02051	COG0835	chemotaxis
J158_02052	COG1192	Involved in chromosome partitioning
J158_02053	COG1360	Flagellar Motor Protein
J158_02054	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
J158_02066	COG2801	Transposase and inactivated derivatives
J158_02067	COG2963	transposase activity
J158_02073	COG0641	radical SAM
J158_02076	COG2198	Histidine kinase
J158_02076	COG0643	Histidine kinase
J158_02080	COG0455	bacterial-type flagellum organization
J158_02082	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J158_02085	COG5001	Diguanylate cyclase
J158_02085	COG3300	MHYT domain
J158_02086	COG5001	Diguanylate cyclase
J158_02086	COG3300	MHYT domain
J158_02087	COG1684	flagellar biosynthetic protein fliR
J158_02088	COG1987	bacterial-type flagellum assembly
J158_02091	COG3190	flagellar
J158_02101	COG1677	Flagellar hook-basal body complex protein FliE
J158_02108	COG1028	Short-chain dehydrogenase reductase Sdr
J158_02109	COG1028	Short-chain dehydrogenase reductase Sdr
J158_02110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J158_02113	COG2204	response regulator
J158_02114	COG2201	protein-glutamate methylesterase activity
J158_02120	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
J158_02121	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J158_02122	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J158_02124	COG3951	Flagellar rod assembly protein muramidase FlgJ
J158_02124	COG1705	Flagellar rod assembly protein muramidase FlgJ
J158_02125	COG1706	bacterial-type flagellum-dependent cell motility
J158_02126	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
J158_02127	COG4786	Flagellar basal body rod
J158_02128	COG4787	bacterial-type flagellum-dependent cell motility
J158_02129	COG1749	Flagellar hook protein flgE
J158_02130	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
J158_02131	COG1558	bacterial-type flagellum-dependent cell motility
J158_02133	COG0784	Response regulator, receiver
J158_02133	COG0835	chemotaxis
J158_02137	COG5002	protein histidine kinase activity
J158_02143	COG2915	High frequency lysogenization protein hflD homolog
J158_02144	COG0482	sulfurtransferase activity
J158_02146	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J158_02147	COG0542	response to heat
J158_02148	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J158_02149	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J158_02151	COG0492	ferredoxin-NADP+ reductase activity
J158_02152	COG1674	ftsk spoiiie
J158_02154	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J158_02156	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J158_02158	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J158_02160	COG0183	Belongs to the thiolase family
J158_02161	COG1024	Enoyl-CoA hydratase
J158_02161	COG1250	3-hydroxyacyl-CoA dehydrogenase
J158_02163	COG0105	UTP biosynthetic process
J158_02164	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J158_02166	COG1426	Protein conserved in bacteria
J158_02168	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J158_02169	COG1160	GTP binding
J158_02170	COG0303	'Molybdopterin
J158_02171	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J158_02178	COG0708	Exodeoxyribonuclease III
J158_02180	COG0303	'Molybdopterin
J158_02181	COG0746	molybdenum cofactor guanylyltransferase activity
J158_02184	COG1914	H( )-stimulated, divalent metal cation uptake system
J158_02185	COG1321	iron dependent repressor
J158_02186	COG0590	tRNA wobble adenosine to inosine editing
J158_02187	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
J158_02188	COG0668	transmembrane transport
J158_02190	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J158_02193	COG1028	Short-chain dehydrogenase reductase Sdr
J158_02194	COG1183	phosphatidylcholine synthase activity
J158_02196	COG3243	poly(R)-hydroxyalkanoic acid synthase
J158_02199	COG0723	plastoquinol--plastocyanin reductase activity
J158_02199	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J158_02201	COG2183	response to ionizing radiation
J158_02202	COG0784	Response regulator, receiver
J158_02202	COG2205	protein histidine kinase activity
J158_02215	COG0800	Aldolase
J158_02216	COG0129	dihydroxy-acid dehydratase activity
J158_02217	COG0363	glucosamine-6-phosphate deaminase activity
J158_02218	COG0837	glucose binding
J158_02219	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J158_02224	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
J158_02227	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J158_02228	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
J158_02230	COG4591	ABC-type transport system involved in lipoprotein release permease component
J158_02231	COG1136	(ABC) transporter
J158_02234	COG0811	peptide transport
J158_02236	COG1132	(ABC) transporter
J158_02237	COG1663	tetraacyldisaccharide 4'-kinase activity
J158_02238	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J158_02239	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J158_02241	COG0322	excinuclease ABC activity
J158_02242	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J158_02246	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J158_02247	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J158_02251	COG2963	transposase activity
J158_02252	COG0582	viral genome integration into host DNA
J158_02254	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J158_02260	COG1530	ribonuclease E activity
J158_02262	COG3064	Membrane
J158_02263	COG0428	transporter
J158_02265	COG2154	pterin-4-alpha-carbinolamine dehydratase
J158_02266	COG0316	Belongs to the HesB IscA family
J158_02266	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
J158_02275	COG2226	methyltransferase
J158_02275	COG1073	alpha beta
J158_02277	COG1028	Short-chain dehydrogenase reductase Sdr
J158_02281	COG2801	Transposase and inactivated derivatives
J158_02282	COG2963	transposase activity
J158_02284	COG1238	metal cluster binding
J158_02290	COG3279	Response regulator of the LytR AlgR family
J158_02298	COG4566	intracellular signal transduction
J158_02300	COG5001	Diguanylate cyclase
J158_02303	COG3685	Protein conserved in bacteria
J158_02307	COG1648	precorrin-2 dehydrogenase activity
J158_02307	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J158_02310	COG2814	Major facilitator Superfamily
J158_02313	COG1335	isochorismatase
J158_02316	COG2197	response regulator
J158_02319	COG0583	DNA-binding transcription factor activity
J158_02320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J158_02321	COG3002	Belongs to the UPF0753 family
J158_02322	COG2801	Transposase and inactivated derivatives
J158_02323	COG2963	transposase activity
J158_02324	COG1396	sequence-specific DNA binding
J158_02325	COG5489	Protein of unknown function (DUF736)
J158_02327	COG2003	Belongs to the UPF0758 family
J158_02332	COG0582	viral genome integration into host DNA
J158_02335	COG4774	siderophore transport
J158_02339	COG2336	PFAM SpoVT AbrB
J158_02344	COG4206	TonB-dependent receptor
J158_02349	COG2273	Hydrolase Family 16
J158_02349	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
J158_02354	COG2274	protein secretion by the type I secretion system
J158_02356	COG1192	Involved in chromosome partitioning
J158_02364	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J158_02364	COG0551	DNA topoisomerase type I activity
J158_02366	COG0270	DNA (cytosine-5-)-methyltransferase activity
J158_02378	COG4804	nuclease activity
J158_02379	COG2963	transposase activity
J158_02380	COG2801	Transposase and inactivated derivatives
J158_02381	COG5006	permease, DMT superfamily
J158_02384	COG2249	NAD(P)H dehydrogenase (quinone) activity
J158_02386	COG3938	Belongs to the proline racemase family
J158_02387	COG0655	NAD(P)H dehydrogenase (quinone) activity
J158_02389	COG2807	transmembrane transport
J158_02390	COG2207	Transcriptional regulator
J158_02420	COG0210	DNA helicase
J158_02436	COG2084	Dehydrogenase
J158_02441	COG2003	Belongs to the UPF0758 family
J158_02448	COG0582	viral genome integration into host DNA
J158_02449	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J158_02449	COG0519	Catalyzes the synthesis of GMP from XMP
J158_02451	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J158_02453	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J158_02453	COG0475	glutathione-regulated potassium exporter activity
J158_02454	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J158_02456	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J158_02457	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
J158_02459	COG0776	regulation of translation
J158_02460	COG0539	negative regulation of cytoplasmic translation
J158_02461	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J158_02462	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J158_02465	COG2957	Belongs to the agmatine deiminase family
J158_02466	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J158_02471	COG0395	ABC-type sugar transport system, permease component
J158_02472	COG1175	transmembrane transport
J158_02478	COG2350	Protein conserved in bacteria
J158_02479	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J158_02480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J158_02481	COG1187	pseudouridine synthase activity
J158_02485	COG0436	Aminotransferase
J158_02486	COG4133	protoheme IX ABC transporter activity
J158_02490	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J158_02491	COG1138	Cytochrome C-type biogenesis protein
J158_02495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J158_02496	COG1278	Cold shock
J158_02497	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J158_02498	COG4988	ABC transporter
J158_02500	COG1294	oxidase, subunit
J158_02505	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J158_02506	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J158_02508	COG0165	Argininosuccinate lyase
J158_02509	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J158_02511	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J158_02514	COG0137	argininosuccinate synthase activity
J158_02515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J158_02517	COG0215	cysteine-tRNA ligase activity
J158_02518	COG2166	iron-sulfur cluster assembly
J158_02520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J158_02521	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J158_02522	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J158_02527	COG4302	ethanolamine ammonia-lyase activity
J158_02533	COG2963	transposase activity
J158_02539	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J158_02540	COG0402	S-adenosylhomocysteine deaminase activity
J158_02542	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J158_02543	COG1509	lysine 2,3-aminomutase activity
J158_02544	COG3300	MHYT domain
J158_02544	COG5001	Diguanylate cyclase
J158_02547	COG0483	inositol monophosphate 1-phosphatase activity
J158_02552	COG0513	Belongs to the DEAD box helicase family
J158_02553	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J158_02554	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J158_02556	COG0625	glutathione transferase activity
J158_02558	COG4681	YaeQ
J158_02559	COG2081	HI0933 family
J158_02561	COG0501	Belongs to the peptidase M48B family
J158_02562	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J158_02563	COG1028	Short-chain dehydrogenase reductase Sdr
J158_02567	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J158_02568	COG0860	N-Acetylmuramoyl-L-alanine amidase
J158_02569	COG0802	atpase or kinase
J158_02570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J158_02570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J158_02571	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J158_02572	COG1570	exodeoxyribonuclease VII activity
J158_02574	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J158_02613	COG0835	chemotaxis
J158_02614	COG0840	transmembrane signaling receptor activity
J158_02615	COG2094	Belongs to the DNA glycosylase MPG family
J158_02616	COG1201	RNA secondary structure unwinding
J158_02619	COG2969	positive regulation of protein catabolic process
J158_02620	COG0625	glutathione transferase activity
J158_02621	COG2857	Cytochrome c1
J158_02622	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J158_02623	COG0723	plastoquinol--plastocyanin reductase activity
J158_02624	COG0741	lytic transglycosylase activity
J158_02627	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J158_02628	COG1702	phosphate starvation-inducible protein PhoH
J158_02630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J158_02632	COG4535	Mg2 and Co2 transporter CorC
J158_02635	COG1012	belongs to the aldehyde dehydrogenase family
J158_02636	COG1177	transmembrane transport
J158_02637	COG1176	ABC-type spermidine putrescine transport system, permease component I
J158_02638	COG3842	ATPase activity
J158_02642	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J158_02645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J158_02646	COG0174	glutamine synthetase
J158_02647	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J158_02648	COG3706	GGDEF domain
J158_02648	COG0745	RESPONSE REGULATOR receiver
J158_02649	COG2703	oxygen carrier activity
J158_02650	COG0477	Major facilitator Superfamily
J158_02652	COG0243	molybdopterin cofactor binding
J158_02653	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J158_02657	COG2733	membrane
J158_02658	COG0784	Response regulator, receiver
J158_02658	COG2205	protein histidine kinase activity
J158_02658	COG5002	protein histidine kinase activity
J158_02660	COG0477	Major facilitator Superfamily
J158_02661	COG2902	Dehydrogenase
J158_02663	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J158_02664	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J158_02665	COG1609	Transcriptional regulator
J158_02666	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J158_02666	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J158_02667	COG1105	Belongs to the carbohydrate kinase PfkB family
J158_02668	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J158_02668	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J158_02674	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J158_02676	COG1862	Preprotein translocase
J158_02677	COG0343	queuine tRNA-ribosyltransferase activity
J158_02678	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J158_02686	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J158_02687	COG3291	Pkd domain containing protein
J158_02688	COG0405	Gamma-glutamyltransferase
J158_02689	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J158_02692	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J158_02693	COG0742	ribosomal rna small subunit methyltransferase
J158_02694	COG0326	Molecular chaperone. Has ATPase activity
J158_02709	COG0531	amino acid
J158_02712	COG0006	proline dipeptidase activity
J158_02714	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J158_02717	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J158_02718	COG3938	Belongs to the proline racemase family
J158_02720	COG0552	protein localization to endoplasmic reticulum
J158_02721	COG1194	a g-specific adenine glycosylase
J158_02722	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
J158_02723	COG4191	Histidine kinase
J158_02723	COG0784	Response regulator, receiver
J158_02726	COG0322	excinuclease ABC activity
J158_02729	COG3040	lipid binding
J158_02731	COG1960	acyl-CoA dehydrogenase activity
J158_02733	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J158_02737	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J158_02738	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J158_02739	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J158_02746	COG0438	transferase activity, transferring glycosyl groups
J158_02747	COG0438	transferase activity, transferring glycosyl groups
J158_02756	COG0776	regulation of translation
J158_02757	COG0072	phenylalanine-tRNA ligase activity
J158_02757	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J158_02758	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J158_02759	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J158_02760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J158_02762	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J158_02763	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J158_02768	COG1082	Xylose isomerase domain protein TIM barrel
J158_02772	COG0366	Alpha amylase catalytic
J158_02774	COG2963	transposase activity
J158_02775	COG2801	Transposase and inactivated derivatives
J158_02784	COG3702	type iv secretory pathway
J158_02788	COG2948	multi-organism process
J158_02792	COG3505	Type IV secretory pathway VirD4
J158_02795	COG0556	nucleotide-excision repair
J158_02803	COG2963	transposase activity
J158_02804	COG2801	Transposase and inactivated derivatives
J158_02812	COG4695	Portal protein
J158_02822	COG3179	chitinase
J158_02832	COG2801	Transposase and inactivated derivatives
J158_02833	COG2963	transposase activity
J158_02838	COG3275	phosphorelay sensor kinase activity
J158_02839	COG1611	Belongs to the LOG family
J158_02841	COG2095	MarC family integral membrane protein
J158_02843	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J158_02844	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J158_02850	COG1185	polyribonucleotide nucleotidyltransferase activity
J158_02851	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J158_02852	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J158_02853	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J158_02854	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J158_02855	COG0195	Participates in both transcription termination and antitermination
J158_02856	COG0779	Required for maturation of 30S ribosomal subunits
J158_02858	COG1007	ATP synthesis coupled electron transport
J158_02861	COG0713	ATP synthesis coupled electron transport
J158_02863	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J158_02864	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J158_02866	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J158_02867	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
J158_02868	COG0649	NAD binding
J158_02869	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J158_02870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J158_02871	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J158_02874	COG0149	triose-phosphate isomerase activity
J158_02875	COG0300	oxidoreductase activity
J158_02881	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J158_02882	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
J158_02883	COG0159	tryptophan synthase activity
J158_02885	COG0133	tryptophan synthase activity
J158_02887	COG0135	phosphoribosylanthranilate isomerase activity
J158_02888	COG0101	tRNA pseudouridine synthase activity
J158_02892	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J158_02893	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J158_02894	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J158_02895	COG2890	protein-(glutamine-N5) methyltransferase activity
J158_02897	COG0688	phosphatidylethanolamine metabolic process
J158_02899	COG0433	COG0433 Predicted ATPase
J158_02900	COG0494	nUDIX hydrolase
J158_02903	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J158_02904	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J158_02909	COG0717	Belongs to the dCTP deaminase family
J158_02910	COG0489	protein tyrosine kinase activity
J158_02914	COG3590	peptidase
J158_02915	COG3590	peptidase
J158_02919	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J158_02920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J158_02921	COG2311	Membrane
J158_02922	COG1047	Peptidyl-prolyl cis-trans
J158_02923	COG0791	NLP P60 protein
J158_02924	COG0791	NLP P60 protein
J158_02926	COG4106	trans-aconitate 2-methyltransferase activity
J158_02927	COG1301	dicarboxylic acid transport
J158_02928	COG1785	Belongs to the alkaline phosphatase family
J158_02929	COG0037	tRNA processing
J158_02930	COG1722	exodeoxyribonuclease VII activity
J158_02931	COG0142	geranyltranstransferase activity
J158_02932	COG4104	PAAR repeat-containing protein
J158_02934	COG0312	modulator of DNA gyrase
J158_02935	COG3028	Belongs to the UPF0307 family
J158_02936	COG0312	modulator of DNA gyrase
J158_02938	COG3164	Protein of unknown function
J158_02939	COG1530	ribonuclease E activity
J158_02940	COG0424	maF-like protein
J158_02941	COG2968	Membrane
J158_02944	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J158_02947	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J158_02950	COG0495	leucyl-tRNA aminoacylation
J158_02952	COG3118	belongs to the thioredoxin family
J158_02957	COG2155	Conserved Protein
J158_02958	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J158_02965	COG1132	(ABC) transporter
J158_02971	COG1538	Outer membrane efflux protein
J158_02972	COG0745	RESPONSE REGULATOR receiver
J158_02973	COG5002	protein histidine kinase activity
J158_02973	COG5000	phosphorelay sensor kinase activity
J158_02974	COG0475	glutathione-regulated potassium exporter activity
J158_02975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J158_02976	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J158_02979	COG3706	GGDEF domain
J158_02979	COG0745	RESPONSE REGULATOR receiver
J158_02980	COG1187	pseudouridine synthase activity
J158_02981	COG5001	Diguanylate cyclase
J158_02981	COG5002	protein histidine kinase activity
J158_03005	COG0667	Aldo Keto reductase
J158_03006	COG2814	Major facilitator Superfamily
J158_03007	COG0583	DNA-binding transcription factor activity
J158_03009	COG2207	Transcriptional regulator
J158_03011	COG1309	transcriptional regulator
J158_03012	COG1538	Outer membrane efflux protein
J158_03016	COG0735	belongs to the Fur family
J158_03017	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J158_03022	COG4452	Inner membrane protein CreD
J158_03024	COG2205	protein histidine kinase activity
J158_03025	COG0745	RESPONSE REGULATOR receiver
J158_03026	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J158_03028	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J158_03035	COG2198	Histidine kinase
J158_03035	COG0643	Histidine kinase
J158_03036	COG0840	transmembrane signaling receptor activity
J158_03037	COG0835	chemotaxis
J158_03038	COG2202	Pas domain
J158_03038	COG2199	diguanylate cyclase activity
J158_03038	COG2200	EAL domain
J158_03039	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J158_03040	COG2201	protein-glutamate methylesterase activity
J158_03041	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J158_03042	COG3590	peptidase
J158_03044	COG0588	phosphoglycerate mutase activity
J158_03045	COG1515	deoxyribonuclease V activity
J158_03047	COG1741	Belongs to the pirin family
J158_03050	COG1741	Belongs to the pirin family
J158_03051	COG1966	Carbon starvation protein
J158_03052	COG2879	small protein
J158_03063	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J158_03064	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J158_03065	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J158_03066	COG2080	2 iron, 2 sulfur cluster binding
J158_03068	COG5001	Diguanylate cyclase
J158_03068	COG3706	GGDEF domain
J158_03068	COG2203	Gaf domain
J158_03068	COG4251	negative regulation of phosphorylation
J158_03069	COG0629	single-stranded DNA binding
J158_03070	COG0142	geranyltranstransferase activity
J158_03072	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J158_03075	COG0527	aspartate kinase activity
J158_03076	COG0384	phenazine biosynthesis protein PhzF
J158_03077	COG0384	phenazine biosynthesis protein PhzF
J158_03079	COG1764	response to oxidative stress
J158_03080	COG0540	Belongs to the ATCase OTCase family
J158_03081	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J158_03082	COG1678	Uncharacterized ACR, COG1678
J158_03083	COG0519	Catalyzes the synthesis of GMP from XMP
J158_03086	COG5297	Belongs to the glycosyl hydrolase family 6
J158_03089	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J158_03092	COG0739	heme binding
J158_03096	COG0693	protein deglycase activity
J158_03098	COG1959	2 iron, 2 sulfur cluster binding
J158_03099	COG0719	Fe-S assembly protein
J158_03100	COG0396	ATPase activity
J158_03101	COG0719	Fe-S assembly protein
J158_03102	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J158_03105	COG4774	siderophore transport
J158_03106	COG3128	pkhd-type hydroxylase
J158_03111	COG1477	protein flavinylation
J158_03112	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J158_03115	COG1555	photosystem II stabilization
J158_03116	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J158_03118	COG3178	'Phosphotransferase
J158_03119	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J158_03121	COG0628	permease
J158_03123	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J158_03125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J158_03129	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J158_03130	COG0271	Belongs to the BolA IbaG family
J158_03132	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J158_03134	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J158_03135	COG1137	ATPase activity
J158_03138	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J158_03139	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
J158_03140	COG1660	Displays ATPase and GTPase activities
J158_03142	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J158_03143	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J158_03144	COG2239	Acts as a magnesium transporter
J158_03146	COG1294	oxidase, subunit
J158_03147	COG1271	oxidase subunit
J158_03149	COG1113	amino acid transport
J158_03152	COG2197	response regulator
J158_03153	COG0531	amino acid
J158_03158	COG1234	tRNA 3'-trailer cleavage
J158_03165	COG2814	Major facilitator Superfamily
J158_03167	COG0754	glutathionylspermidine amidase activity
J158_03172	COG1842	Phage shock protein A
J158_03174	COG0259	pyridoxamine-phosphate oxidase activity
J158_03175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J158_03176	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J158_03178	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J158_03192	COG2814	Major facilitator Superfamily
J158_03196	COG0784	Response regulator, receiver
J158_03196	COG2205	protein histidine kinase activity
J158_03196	COG2198	Histidine kinase
J158_03197	COG2353	YceI-like domain
J158_03201	COG1760	l-serine dehydratase
J158_03203	COG0527	aspartate kinase activity
J158_03203	COG0460	homoserine dehydrogenase
J158_03204	COG0626	cystathionine gamma-synthase activity
J158_03205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J158_03207	COG0739	heme binding
J158_03208	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J158_03209	COG1272	protein, Hemolysin III
J158_03210	COG2982	Protein involved in outer membrane biogenesis
J158_03211	COG0517	IMP dehydrogenase activity
J158_03211	COG0516	GMP reductase activity
J158_03212	COG0463	Glycosyl transferase, family 2
J158_03213	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J158_03214	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J158_03216	COG4771	TonB-dependent receptor
J158_03218	COG1309	transcriptional regulator
J158_03219	COG2267	carboxylic ester hydrolase activity
J158_03220	COG1960	acyl-CoA dehydrogenase activity
J158_03225	COG0509	glycine decarboxylation via glycine cleavage system
J158_03226	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J158_03228	COG0330	HflC and HflK could
J158_03229	COG1742	UPF0060 membrane protein
J158_03230	COG3956	TIGRFAM MazG family protein
J158_03232	COG0494	nUDIX hydrolase
J158_03234	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J158_03235	COG0837	glucose binding
J158_03238	COG3858	chitin binding
J158_03238	COG1388	LysM domain
J158_03239	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J158_03241	COG1472	Belongs to the glycosyl hydrolase 3 family
J158_03244	COG0531	amino acid
J158_03246	COG1486	melibiose metabolic process
J158_03248	COG3537	Alpha-1,2-mannosidase
J158_03255	COG3142	Participates in the control of copper homeostasis
J158_03256	COG1446	asparaginase
J158_03261	COG0840	transmembrane signaling receptor activity
J158_03265	COG0189	ligase activity
J158_03267	COG1397	ADP-ribosylglycohydrolase
J158_03269	COG1199	ATP-dependent helicase activity
J158_03271	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J158_03272	COG1215	transferase activity, transferring glycosyl groups
J158_03274	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J158_03275	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J158_03276	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
J158_03277	COG0535	radical SAM domain protein
J158_03278	COG0535	radical SAM domain protein
J158_03281	COG0837	glucose binding
J158_03283	COG1643	Atp-dependent helicase
J158_03284	COG0783	Belongs to the Dps family
J158_03285	COG0514	ATP-dependent DNA helicase (RecQ)
J158_03292	COG0840	transmembrane signaling receptor activity
J158_03296	COG3920	Histidine kinase
J158_03297	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J158_03299	COG0602	queuosine metabolic process
J158_03301	COG2885	chlorophyll binding
J158_03302	COG0823	Involved in the tonB-independent uptake of proteins
J158_03304	COG0848	biopolymer transport protein
J158_03306	COG0824	Thioesterase
J158_03307	COG2255	four-way junction helicase activity
J158_03309	COG3158	transport of potassium into the cell
J158_03310	COG0632	four-way junction helicase activity
J158_03311	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J158_03312	COG0217	transcriptional regulatory protein
J158_03315	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J158_03318	COG0477	Major facilitator Superfamily
J158_03326	COG0488	(ABC) transporter
J158_03332	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J158_03332	COG4651	solute:proton antiporter activity
J158_03337	COG4772	TonB-dependent receptor
J158_03339	COG4264	IucA IucC family
J158_03342	COG0019	diaminopimelate decarboxylase activity
J158_03347	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J158_03349	COG1492	cobalamin metabolic process
J158_03352	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J158_03356	COG4206	TonB-dependent receptor
J158_03358	COG0542	response to heat
J158_03359	COG1116	anion transmembrane transporter activity
J158_03360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J158_03361	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J158_03362	COG0667	Aldo Keto reductase
J158_03364	COG4771	TonB-dependent receptor
J158_03365	COG2827	Endonuclease containing a URI domain
J158_03373	COG1877	trehalose-phosphatase activity
J158_03374	COG3387	PFAM Glycoside hydrolase 15-related
J158_03377	COG0840	transmembrane signaling receptor activity
J158_03378	COG3011	Protein conserved in bacteria
J158_03381	COG0564	pseudouridine synthase activity
J158_03382	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J158_03384	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J158_03384	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J158_03386	COG2963	transposase activity
J158_03387	COG2801	Transposase and inactivated derivatives
J158_03390	COG2951	lytic endotransglycosylase activity
J158_03391	COG4644	lycopene metabolic process
J158_03395	COG2369	cell adhesion
J158_03400	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J158_03401	COG0045	succinate-CoA ligase (ADP-forming) activity
J158_03405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J158_03411	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
J158_03412	COG0237	dephospho-CoA kinase activity
J158_03415	COG2963	transposase activity
J158_03417	COG5002	protein histidine kinase activity
J158_03418	COG0745	RESPONSE REGULATOR receiver
J158_03420	COG0189	ligase activity
J158_03434	COG2003	Belongs to the UPF0758 family
J158_03439	COG4191	Histidine kinase
J158_03439	COG0784	Response regulator, receiver
J158_03440	COG4191	Histidine kinase
J158_03440	COG0784	Response regulator, receiver
J158_03459	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J158_03465	COG2022	thiamine diphosphate biosynthetic process
J158_03466	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J158_03467	COG3273	potassium ion transport
J158_03467	COG0471	metal ion transport
J158_03471	COG1970	mechanosensitive ion channel activity
J158_03475	COG3250	beta-galactosidase activity
J158_03476	COG4948	Mandelate Racemase Muconate Lactonizing
J158_03479	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J158_03481	COG0308	aminopeptidase N
J158_03483	COG2801	Transposase and inactivated derivatives
J158_03484	COG2963	transposase activity
J158_03490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J158_03492	COG0529	Catalyzes the synthesis of activated sulfate
J158_03492	COG2895	sulfate adenylyltransferase (ATP) activity
J158_03493	COG0175	sulfate reduction
J158_03494	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J158_03495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J158_03496	COG0175	sulfate reduction
J158_03503	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J158_03503	COG1648	precorrin-2 dehydrogenase activity
J158_03506	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
J158_03507	COG3588	fructose-bisphosphate aldolase
J158_03508	COG0469	pyruvate kinase activity
J158_03510	COG0126	phosphoglycerate kinase activity
J158_03515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J158_03517	COG3047	cAMP biosynthetic process
J158_03518	COG3047	cAMP biosynthetic process
J158_03520	COG3453	Protein conserved in bacteria
J158_03520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J158_03521	COG0725	ABC transporter, periplasmic molybdate-binding protein
J158_03522	COG4149	molybdate abc transporter
J158_03523	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J158_03530	COG1376	ErfK ybiS ycfS ynhG family protein
J158_03531	COG0739	heme binding
J158_03533	COG4773	Receptor
J158_03534	COG0596	Alpha beta hydrolase
J158_03535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J158_03536	COG1301	dicarboxylic acid transport
J158_03538	COG2304	oxidoreductase activity
J158_03542	COG0714	Associated with various cellular activities
J158_03549	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J158_03552	COG0254	rRNA binding
J158_03554	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J158_03556	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J158_03557	COG1758	RNA polymerase activity
J158_03558	COG0194	GDP metabolic process
J158_03559	COG1561	YicC-like family, N-terminal region
J158_03560	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J158_03562	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J158_03563	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J158_03566	COG0006	proline dipeptidase activity
J158_03568	COG0006	proline dipeptidase activity
J158_03569	COG3079	Belongs to the UPF0149 family
J158_03573	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J158_03575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J158_03577	COG2912	Transglutaminase-like superfamily
J158_03578	COG1773	rubredoxin
J158_03579	COG0352	thiamine-phosphate diphosphorylase activity
J158_03582	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J158_03585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J158_03591	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J158_03592	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J158_03593	COG1028	Short-chain dehydrogenase reductase Sdr
J158_03595	COG0671	phosphoesterase, PA-phosphatase related
J158_03596	COG3781	membrane
J158_03598	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J158_03599	COG0563	adenylate kinase activity
J158_03602	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J158_03604	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J158_03608	COG3710	Transcriptional regulator
J158_03609	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J158_03612	COG0840	transmembrane signaling receptor activity
J158_03613	COG0405	Gamma-glutamyltransferase
J158_03614	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J158_03618	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J158_03619	COG0473	3-isopropylmalate dehydrogenase activity
J158_03620	COG0066	3-isopropylmalate dehydratase activity
J158_03621	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J158_03625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J158_03626	COG1538	Outer membrane efflux protein
J158_03627	COG1519	Transferase
J158_03628	COG1560	Kdo2-lipid A biosynthetic process
J158_03633	COG0281	malic enzyme
J158_03633	COG0280	phosphate acetyltransferase
J158_03634	COG1301	dicarboxylic acid transport
J158_03639	COG0583	DNA-binding transcription factor activity
J158_03640	COG0667	Aldo Keto reductase
J158_03644	COG2197	response regulator
J158_03645	COG1840	ABC-type Fe3 transport system, periplasmic component
J158_03646	COG0642	Histidine kinase
J158_03649	COG2851	Citrate transporter
J158_03651	COG1028	Short-chain dehydrogenase reductase Sdr
J158_03652	COG1609	Transcriptional regulator
J158_03653	COG2211	Major facilitator Superfamily
J158_03658	COG1162	GTPase activity
J158_03662	COG4773	Receptor
J158_03663	COG0726	polysaccharide deacetylase
J158_03664	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J158_03667	COG2963	transposase activity
J158_03668	COG2801	Transposase and inactivated derivatives
J158_03672	COG1307	EDD domain protein, DegV family
J158_03673	COG0242	peptide deformylase activity
J158_03677	COG0457	Tetratricopeptide repeat
J158_03678	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
J158_03679	COG1215	transferase activity, transferring glycosyl groups
J158_03680	COG1215	transferase activity, transferring glycosyl groups
J158_03683	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J158_03692	COG2188	Transcriptional regulator
J158_03694	COG1450	Type ii and iii secretion system protein
J158_03695	COG1450	Type ii and iii secretion system protein
J158_03698	COG3166	PFAM Fimbrial assembly family protein
J158_03699	COG3156	type II secretion system protein K
J158_03700	COG4795	General secretion pathway protein
J158_03701	COG2165	general secretion pathway protein
J158_03702	COG4970	Tfp pilus assembly protein FimT
J158_03703	COG2165	general secretion pathway protein
J158_03704	COG1459	type II secretion system
J158_03705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J158_03706	COG1404	Belongs to the peptidase S8 family
J158_03707	COG5295	Hep Hag repeat protein
J158_03708	COG1404	Belongs to the peptidase S8 family
J158_03709	COG5295	Hep Hag repeat protein
J158_03710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J158_03710	COG0047	phosphoribosylformylglycinamidine synthase activity
J158_03711	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J158_03712	COG4974	Belongs to the 'phage' integrase family
J158_03715	COG0795	lipopolysaccharide-transporting ATPase activity
J158_03717	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J158_03720	COG0525	valine-tRNA ligase activity
J158_03726	COG1183	phosphatidylcholine synthase activity
J158_03728	COG0442	prolyl-tRNA aminoacylation
J158_03731	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J158_03732	COG1127	ABC transporter
J158_03733	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J158_03733	COG3218	ABC-type transport auxiliary lipoprotein component
J158_03740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J158_03741	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
J158_03741	COG0662	Cupin 2, conserved barrel domain protein
J158_03747	COG2086	electron transfer activity
J158_03750	COG0546	phosphoglycolate phosphatase activity
J158_03750	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J158_03751	COG0277	FAD linked oxidase domain protein
J158_03754	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J158_03760	COG1216	Glycosyl transferase, family 2
J158_03760	COG0438	transferase activity, transferring glycosyl groups
J158_03764	COG0626	cystathionine gamma-synthase activity
J158_03770	COG0625	glutathione transferase activity
J158_03772	COG0513	Belongs to the DEAD box helicase family
J158_03775	COG4206	TonB-dependent receptor
J158_03776	COG0720	synthase
J158_03778	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J158_03779	COG1956	GAF domain-containing protein
J158_03781	COG2819	hydrolase of the alpha beta superfamily
J158_03784	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J158_03785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J158_03788	COG0339	signal peptide processing
J158_03791	COG2132	Multicopper oxidase
J158_03799	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J158_03800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J158_03801	COG4591	ABC-type transport system involved in lipoprotein release permease component
J158_03801	COG1136	(ABC) transporter
J158_03802	COG1136	(ABC) transporter
J158_03802	COG0577	efflux transmembrane transporter activity
J158_03803	COG0577	efflux transmembrane transporter activity
J158_03805	COG2204	response regulator
J158_03806	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J158_03809	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J158_03810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J158_03811	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J158_03812	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J158_03813	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J158_03814	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J158_03816	COG0356	it plays a direct role in the translocation of protons across the membrane
J158_03820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J158_03822	COG0508	dehydrogenase complex catalyzes the overall conversion of
J158_03829	COG2011	ABC-type metal ion transport system permease component
J158_03830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J158_03831	COG0697	spore germination
J158_03832	COG1666	GTP binding
J158_03834	COG0784	Response regulator, receiver
J158_03834	COG5002	protein histidine kinase activity
J158_03834	COG2198	Histidine kinase
J158_03838	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J158_03839	COG1187	pseudouridine synthase activity
J158_03840	COG2813	Specifically methylates the guanine in position
J158_03844	COG2202	Pas domain
J158_03844	COG2205	protein histidine kinase activity
J158_03848	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J158_03849	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J158_03850	COG1522	sequence-specific DNA binding
J158_03860	COG0842	Transport permease protein
J158_03861	COG1131	(ABC) transporter
J158_03862	COG0025	NhaP-type Na H and K H
J158_03863	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
J158_03864	COG1573	uracil-dna glycosylase
J158_03866	COG3384	dioxygenase
J158_03868	COG0583	DNA-binding transcription factor activity
J158_03870	COG0667	Aldo Keto reductase
J158_03872	COG3590	peptidase
J158_03876	COG0531	amino acid
J158_03879	COG2972	Histidine kinase
J158_03882	COG3685	Protein conserved in bacteria
J158_03883	COG3546	catalase activity
J158_03891	COG1271	oxidase subunit
J158_03892	COG1294	oxidase, subunit
J158_03895	COG1028	Short-chain dehydrogenase reductase Sdr
J158_03896	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J158_03900	COG1132	(ABC) transporter
J158_03903	COG1063	alcohol dehydrogenase
J158_03918	COG0251	oxidation-reduction process
J158_03924	COG0840	transmembrane signaling receptor activity
J158_03928	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J158_03937	COG0024	Methionine aminopeptidase
J158_03942	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J158_03943	COG1490	D-aminoacyl-tRNA deacylase activity
J158_03944	COG1560	Kdo2-lipid A biosynthetic process
J158_03953	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J158_03953	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J158_03954	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J158_03955	COG0242	peptide deformylase activity
J158_03956	COG1652	LysM domain
J158_03957	COG0758	DNA mediated transformation
J158_03958	COG2922	Belongs to the Smg family
J158_03961	COG1754	DNA topoisomerase type I activity
J158_03961	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J158_03962	COG0009	L-threonylcarbamoyladenylate synthase
J158_03965	COG1028	Short-chain dehydrogenase reductase Sdr
J158_03967	COG0616	signal peptide processing
J158_03968	COG0534	Mate efflux family protein
J158_03972	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J158_03973	COG0625	glutathione transferase activity
J158_03976	COG1252	NADH dehydrogenase
J158_03977	COG2860	membrane
J158_03978	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J158_03979	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J158_03980	COG2201	protein-glutamate methylesterase activity
J158_03981	COG2177	Part of the ABC transporter FtsEX involved in
J158_03982	COG2884	Cell division ATP-binding protein ftsE
J158_03983	COG0513	Belongs to the DEAD box helicase family
J158_03984	COG3118	belongs to the thioredoxin family
J158_03985	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J158_03986	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
J158_03987	COG0583	DNA-binding transcription factor activity
J158_03997	COG1518	maintenance of DNA repeat elements
J158_03998	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J158_04000	COG1652	LysM domain
J158_04001	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J158_04001	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J158_04002	COG1473	amidohydrolase
J158_04003	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J158_04004	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J158_04006	COG5383	Protein conserved in bacteria
J158_04014	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
J158_04015	COG3023	N-Acetylmuramoyl-L-alanine amidase
J158_04017	COG4948	Mandelate Racemase Muconate Lactonizing
J158_04019	COG0531	amino acid
J158_04022	COG4682	membrane
J158_04023	COG2133	pyrroloquinoline quinone binding
J158_04025	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J158_04026	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J158_04027	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J158_04028	COG1610	YqeY-like protein
J158_04029	COG1295	ribonuclease BN
J158_04030	COG0358	DNA primase activity
J158_04033	COG0109	protoheme IX farnesyltransferase activity
J158_04039	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
J158_04042	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J158_04052	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J158_04053	COG0739	heme binding
J158_04054	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
J158_04056	COG2223	nitrite transmembrane transporter activity
J158_04057	COG0708	Exodeoxyribonuclease III
J158_04058	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J158_04060	COG1192	Involved in chromosome partitioning
J158_04061	COG1475	DNA binding
J158_04064	COG0463	Glycosyl transferase, family 2
J158_04068	COG0756	dUTP diphosphatase activity
J158_04069	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J158_04070	COG2003	Belongs to the UPF0758 family
J158_04071	COG0018	arginyl-trna synthetase
J158_04074	COG4221	oxidoreductase activity
J158_04075	COG2755	lipolytic protein G-D-S-L family
J158_04075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J158_04077	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J158_04078	COG1166	arginine decarboxylase activity
J158_04079	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J158_04086	COG0606	chelatase, subunit chli
J158_04089	COG4943	cyclic-guanylate-specific phosphodiesterase activity
J158_04098	COG1690	Belongs to the RtcB family
J158_04106	COG1090	epimerase
J158_04107	COG0745	RESPONSE REGULATOR receiver
J158_04108	COG0642	Histidine kinase
J158_04112	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J158_04117	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J158_04118	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J158_04121	COG0753	catalase activity
J158_04124	COG2197	response regulator
J158_04125	COG4585	Histidine kinase
J158_04126	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J158_04127	COG1136	(ABC) transporter
J158_04131	COG2962	Rard protein
J158_04133	COG0697	spore germination
J158_04136	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J158_04137	COG0180	Tryptophanyl-tRNA synthetase
J158_04138	COG3237	CsbD-like
J158_04146	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J158_04149	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J158_04150	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J158_04150	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J158_04155	COG2205	protein histidine kinase activity
J158_04156	COG0745	RESPONSE REGULATOR receiver
J158_04158	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J158_04162	COG1199	ATP-dependent helicase activity
J158_04165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J158_04176	COG0625	glutathione transferase activity
J158_04183	COG4555	ABC transporter
J158_04185	COG1476	TRANSCRIPTIONal
J158_04194	COG0543	2 iron, 2 sulfur cluster binding
J158_04194	COG0633	Ferredoxin
J158_04195	COG1131	(ABC) transporter
J158_04196	COG0842	Transport permease protein
J158_04199	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J158_04205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J158_04206	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J158_04208	COG0045	succinate-CoA ligase (ADP-forming) activity
J158_04208	COG1042	CoA-binding domain protein
J158_04208	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J158_04209	COG2239	Acts as a magnesium transporter
J158_04210	COG3338	carbonate dehydratase activity
J158_04212	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J158_04213	COG3387	PFAM Glycoside hydrolase 15-related
J158_04216	COG3100	YcgL domain-containing protein
J158_04217	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J158_04219	COG0463	Glycosyl transferase, family 2
J158_04222	COG1028	Short-chain dehydrogenase reductase Sdr
J158_04230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J158_04233	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J158_04238	COG1506	peptidase
J158_04238	COG0823	Involved in the tonB-independent uptake of proteins
J158_04238	COG4946	Tricorn protease homolog
J158_04241	COG0408	coproporphyrinogen oxidase activity
J158_04248	COG2815	serine threonine protein kinase
J158_04248	COG0515	serine threonine protein kinase
J158_04249	COG0631	protein serine/threonine phosphatase activity
J158_04256	COG3501	Rhs element vgr protein
J158_04282	COG0210	DNA helicase
J158_04284	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J158_04285	COG0583	DNA-binding transcription factor activity
J158_04286	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J158_04288	COG2159	amidohydrolase
J158_04289	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J158_04290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J158_04292	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J158_04296	COG0357	Ribosomal RNA small subunit methyltransferase G
J158_04297	COG3540	Alkaline phosphatase
J158_04300	COG2091	lysine biosynthetic process via aminoadipic acid
J158_04303	COG0708	Exodeoxyribonuclease III
J158_04305	COG1940	carbohydrate kinase activity
J158_04305	COG1846	Transcriptional regulator
J158_04307	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J158_04309	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J158_04310	COG3162	membrane
J158_04312	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J158_04318	COG3507	Belongs to the glycosyl hydrolase 43 family
J158_04321	COG1028	Short-chain dehydrogenase reductase Sdr
J158_04322	COG0179	Fumarylacetoacetate (FAA) hydrolase
J158_04323	COG4948	Mandelate Racemase Muconate Lactonizing
J158_04325	COG3254	rhamnose metabolic process
J158_04326	COG0738	Major facilitator superfamily
J158_04327	COG1414	Transcriptional regulator
J158_04328	COG1971	Probably functions as a manganese efflux pump
J158_04329	COG2205	protein histidine kinase activity
J158_04331	COG3459	Glycosyltransferase 36 associated
J158_04332	COG2211	Major facilitator Superfamily
J158_04333	COG3265	gluconokinase activity
J158_04334	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J158_04338	COG2911	Protein conserved in bacteria
J158_04339	COG0729	surface antigen
J158_04342	COG2963	transposase activity
J158_04343	COG2801	Transposase and inactivated derivatives
J158_04347	COG0752	glycyl-tRNA synthetase alpha subunit
J158_04348	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J158_04350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J158_04350	COG0519	Catalyzes the synthesis of GMP from XMP
J158_04352	COG0805	protein transport
J158_04353	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J158_04354	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J158_04356	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J158_04359	COG2974	May be involved in recombination
J158_04360	COG0037	tRNA processing
J158_04361	COG2115	Belongs to the xylose isomerase family
J158_04363	COG3661	Belongs to the glycosyl hydrolase 67 family
J158_04365	COG4948	Mandelate Racemase Muconate Lactonizing
J158_04367	COG1472	Belongs to the glycosyl hydrolase 3 family
J158_04368	COG0246	Mannitol dehydrogenase
J158_04376	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J158_04377	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J158_04382	COG3386	PFAM SMP-30 Gluconolaconase
J158_04384	COG3250	beta-galactosidase activity
J158_04385	COG1904	glucuronate isomerase
J158_04386	COG3693	PFAM glycoside hydrolase, family 10
J158_04388	COG3693	PFAM glycoside hydrolase, family 10
J158_04391	COG2211	Major facilitator Superfamily
J158_04401	COG2937	Belongs to the GPAT DAPAT family
J158_04407	COG0284	orotidine-5'-phosphate decarboxylase activity
J158_04408	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
J158_04410	COG3132	Protein of unknown function, DUF480
J158_04413	COG0210	DNA helicase
J158_04414	COG1435	thymidine kinase activity
J158_04416	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
J158_04418	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J158_04425	COG3135	benzoate transporter
J158_04429	COG0676	glucose-6-phosphate 1-epimerase activity
J158_04431	COG3012	SEC-C Motif Domain Protein
J158_04432	COG0730	response to heat
J158_04436	COG0302	gtp cyclohydrolase
J158_04439	COG1566	PFAM secretion protein HlyD family protein
J158_04441	COG1289	transmembrane transporter activity
J158_04442	COG0477	Major facilitator Superfamily
J158_04444	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J158_04448	COG4691	Plasmid stability protein
J158_04449	COG1487	ribonuclease activity
J158_04454	COG0564	pseudouridine synthase activity
J158_04456	COG2963	transposase activity
J158_04457	COG2801	Transposase and inactivated derivatives
J158_04460	COG0439	Biotin carboxylase
J158_04471	COG1074	ATP-dependent DNA helicase activity
J158_04472	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J158_04474	COG1127	ABC transporter
J158_04475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J158_04476	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J158_04479	COG2853	Lipoprotein
J158_04481	COG0386	Belongs to the glutathione peroxidase family
J158_04483	COG1322	Protein conserved in bacteria
J158_04484	COG0604	alcohol dehydrogenase
J158_04485	COG0583	DNA-binding transcription factor activity
J158_04487	COG0625	glutathione transferase activity
J158_04489	COG0531	amino acid
J158_04490	COG3537	Alpha-1,2-mannosidase
J158_04492	COG3706	GGDEF domain
J158_04493	COG3835	regulator
J158_04494	COG1929	Belongs to the glycerate kinase type-1 family
J158_04495	COG2271	Major facilitator Superfamily
J158_04498	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J158_04500	COG0861	Integral membrane protein TerC family
J158_04502	COG0584	glycerophosphoryl diester phosphodiesterase
J158_04505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J158_04506	COG0726	polysaccharide deacetylase
J158_04507	COG0706	membrane insertase activity
J158_04508	COG0594	ribonuclease P activity
J158_04509	COG0230	Belongs to the bacterial ribosomal protein bL34 family