locus-tag	class	description
K4A87_00035	COG0187	DNA topoisomerase II activity
K4A87_00045	COG0501	Belongs to the peptidase M48B family
K4A87_00095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K4A87_00105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K4A87_00140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K4A87_00145	COG0793	Belongs to the peptidase S41A family
K4A87_00150	COG4942	peptidase
K4A87_00160	COG2234	aminopeptidase activity
K4A87_00195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K4A87_00205	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K4A87_00205	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K4A87_00215	COG1652	LysM domain
K4A87_00250	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K4A87_00255	COG3118	belongs to the thioredoxin family
K4A87_00265	COG2884	Cell division ATP-binding protein ftsE
K4A87_00270	COG2177	Part of the ABC transporter FtsEX involved in
K4A87_00275	COG2201	protein-glutamate methylesterase activity
K4A87_00280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K4A87_00285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K4A87_00295	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K4A87_00315	COG0534	Mate efflux family protein
K4A87_00320	COG0616	signal peptide processing
K4A87_00330	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_00340	COG0277	FAD linked oxidase domain protein
K4A87_00405	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K4A87_00410	COG5383	Protein conserved in bacteria
K4A87_00440	COG1609	Transcriptional regulator
K4A87_00445	COG0037	tRNA processing
K4A87_00450	COG2974	May be involved in recombination
K4A87_00470	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K4A87_00485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K4A87_00490	COG0805	protein transport
K4A87_00505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K4A87_00505	COG0519	Catalyzes the synthesis of GMP from XMP
K4A87_00510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K4A87_00535	COG0067	glutamate synthase
K4A87_00535	COG0069	glutamate synthase activity
K4A87_00535	COG0070	glutamate synthase
K4A87_00540	COG0493	'glutamate synthase
K4A87_00545	COG1064	alcohol dehydrogenase
K4A87_00550	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K4A87_00560	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K4A87_00615	COG0366	Alpha amylase catalytic
K4A87_00620	COG0366	Alpha amylase catalytic
K4A87_00625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K4A87_00640	COG0657	acetylesterase activity
K4A87_00640	COG2755	lipolytic protein G-D-S-L family
K4A87_00650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K4A87_00670	COG1609	Transcriptional regulator
K4A87_00680	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K4A87_00685	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_00690	COG3186	Phenylalanine-4-hydroxylase
K4A87_00695	COG1522	sequence-specific DNA binding
K4A87_00700	COG1119	ATPase activity
K4A87_00720	COG1125	glycine betaine transport
K4A87_00735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K4A87_00765	COG0489	protein tyrosine kinase activity
K4A87_00770	COG2062	phosphohistidine phosphatase, SixA
K4A87_00780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K4A87_00825	COG0174	glutamine synthetase
K4A87_00830	COG0347	Belongs to the P(II) protein family
K4A87_00835	COG0004	ammonium transporteR
K4A87_00840	COG3852	Histidine kinase
K4A87_00845	COG2204	response regulator
K4A87_00850	COG2032	superoxide dismutase activity
K4A87_00855	COG2032	superoxide dismutase activity
K4A87_00870	COG0183	Belongs to the thiolase family
K4A87_00905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K4A87_00915	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K4A87_00925	COG0028	Belongs to the TPP enzyme family
K4A87_00935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K4A87_00945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K4A87_00950	COG3177	Filamentation induced by cAMP protein fic
K4A87_00955	COG0596	Alpha beta hydrolase
K4A87_00965	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_00970	COG0727	PFAM Uncharacterised protein family (UPF0153)
K4A87_00975	COG0318	PFAM AMP-dependent synthetase and ligase
K4A87_00980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K4A87_01045	COG0339	signal peptide processing
K4A87_01100	COG4770	biotin carboxylase activity
K4A87_01105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K4A87_01110	COG1960	acyl-CoA dehydrogenase activity
K4A87_01175	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K4A87_01185	COG1764	response to oxidative stress
K4A87_01200	COG0656	L-ascorbic acid biosynthetic process
K4A87_01205	COG2130	NADP-dependent
K4A87_01220	COG1187	pseudouridine synthase activity
K4A87_01260	COG1643	Atp-dependent helicase
K4A87_01275	COG4807	Protein conserved in bacteria
K4A87_01285	COG0084	hydrolase, TatD family'
K4A87_01290	COG2814	Major facilitator Superfamily
K4A87_01300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K4A87_01305	COG1902	pentaerythritol trinitrate reductase activity
K4A87_01340	COG0745	RESPONSE REGULATOR receiver
K4A87_01345	COG2205	protein histidine kinase activity
K4A87_01370	COG1733	regulation of RNA biosynthetic process
K4A87_01435	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K4A87_01480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K4A87_01525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K4A87_01565	COG0156	8-amino-7-oxononanoate synthase activity
K4A87_01570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K4A87_01575	COG1040	competence protein
K4A87_01605	COG1404	Belongs to the peptidase S8 family
K4A87_01625	COG1511	domain protein
K4A87_01625	COG3264	Mechanosensitive ion channel
K4A87_01630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K4A87_01635	COG2354	Protein conserved in bacteria
K4A87_01640	COG1649	PFAM Uncharacterised BCR, COG1649
K4A87_01650	COG0297	glycogen (starch) synthase activity
K4A87_01655	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K4A87_01660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K4A87_01690	COG0702	epimerase
K4A87_01700	COG1858	cytochrome C peroxidase
K4A87_01785	COG4232	protein-disulfide reductase activity
K4A87_01790	COG1324	tolerance protein
K4A87_01810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K4A87_01820	COG1196	nuclear chromosome segregation
K4A87_01865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K4A87_01885	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K4A87_01890	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K4A87_01905	COG2353	YceI-like domain
K4A87_01990	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_02005	COG1131	(ABC) transporter
K4A87_02070	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_02110	COG1132	(ABC) transporter
K4A87_02130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K4A87_02135	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_02155	COG2204	response regulator
K4A87_02190	COG3546	catalase activity
K4A87_02195	COG3685	Protein conserved in bacteria
K4A87_02210	COG0531	amino acid
K4A87_02225	COG3590	peptidase
K4A87_02245	COG1573	uracil-dna glycosylase
K4A87_02255	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K4A87_02270	COG0025	NhaP-type Na H and K H
K4A87_02325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K4A87_02330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K4A87_02345	COG2205	protein histidine kinase activity
K4A87_02345	COG2202	Pas domain
K4A87_02370	COG1187	pseudouridine synthase activity
K4A87_02405	COG1666	GTP binding
K4A87_02430	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K4A87_02450	COG0180	Tryptophanyl-tRNA synthetase
K4A87_02500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K4A87_02505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K4A87_02535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K4A87_02555	COG0642	Histidine kinase
K4A87_02570	COG1090	epimerase
K4A87_02605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K4A87_02610	COG2011	ABC-type metal ion transport system permease component
K4A87_02640	COG0508	dehydrogenase complex catalyzes the overall conversion of
K4A87_02650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K4A87_02665	COG0356	it plays a direct role in the translocation of protons across the membrane
K4A87_02675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K4A87_02680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K4A87_02700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K4A87_02715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K4A87_02730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K4A87_02770	COG0339	signal peptide processing
K4A87_02785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K4A87_02790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K4A87_02795	COG0546	phosphoglycolate phosphatase activity
K4A87_02830	COG1956	GAF domain-containing protein
K4A87_02835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K4A87_02845	COG0720	synthase
K4A87_02850	COG0513	Belongs to the DEAD box helicase family
K4A87_02860	COG0625	glutathione transferase activity
K4A87_02895	COG0626	cystathionine gamma-synthase activity
K4A87_02910	COG0110	maltose O-acetyltransferase activity
K4A87_02915	COG0438	transferase activity, transferring glycosyl groups
K4A87_02915	COG1216	Glycosyl transferase, family 2
K4A87_02920	COG3754	Rhamnan synthesis protein F
K4A87_02950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K4A87_02960	COG0300	oxidoreductase activity
K4A87_02965	COG0277	FAD linked oxidase domain protein
K4A87_02970	COG0546	phosphoglycolate phosphatase activity
K4A87_02970	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K4A87_02985	COG2086	electron transfer activity
K4A87_03005	COG1091	dTDP-4-dehydrorhamnose reductase activity
K4A87_03010	COG0662	Cupin 2, conserved barrel domain protein
K4A87_03010	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K4A87_03015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K4A87_03050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K4A87_03050	COG3218	ABC-type transport auxiliary lipoprotein component
K4A87_03055	COG1127	ABC transporter
K4A87_03060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K4A87_03075	COG0442	prolyl-tRNA aminoacylation
K4A87_03090	COG1183	phosphatidylcholine synthase activity
K4A87_03105	COG0525	valine-tRNA ligase activity
K4A87_03125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K4A87_03135	COG0795	lipopolysaccharide-transporting ATPase activity
K4A87_03150	COG4974	Belongs to the 'phage' integrase family
K4A87_03155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K4A87_03165	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K4A87_03165	COG0047	phosphoribosylformylglycinamidine synthase activity
K4A87_03185	COG5295	Hep Hag repeat protein
K4A87_03190	COG1404	Belongs to the peptidase S8 family
K4A87_03195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K4A87_03200	COG1459	type II secretion system
K4A87_03210	COG2165	general secretion pathway protein
K4A87_03215	COG4970	Tfp pilus assembly protein FimT
K4A87_03220	COG2165	general secretion pathway protein
K4A87_03225	COG4795	General secretion pathway protein
K4A87_03230	COG3156	type II secretion system protein K
K4A87_03235	COG3166	PFAM Fimbrial assembly family protein
K4A87_03250	COG1450	Type ii and iii secretion system protein
K4A87_03275	COG2188	Transcriptional regulator
K4A87_03325	COG0242	peptide deformylase activity
K4A87_03330	COG0488	(ABC) transporter
K4A87_03340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K4A87_03355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K4A87_03355	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K4A87_03370	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K4A87_03380	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K4A87_03435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K4A87_03545	COG0792	nuclease activity
K4A87_03585	COG0275	rRNA processing
K4A87_03590	COG3116	cell division
K4A87_03600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K4A87_03605	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K4A87_03610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K4A87_03620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K4A87_03625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K4A87_03630	COG1181	Belongs to the D-alanine--D-alanine ligase family
K4A87_03635	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K4A87_03660	COG0739	heme binding
K4A87_03665	COG0653	protein targeting
K4A87_03675	COG0494	nUDIX hydrolase
K4A87_03685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K4A87_03695	COG3321	synthase
K4A87_03695	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_03695	COG0604	alcohol dehydrogenase
K4A87_03780	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K4A87_03795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K4A87_03805	COG4106	trans-aconitate 2-methyltransferase activity
K4A87_03810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K4A87_03820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K4A87_03835	COG0642	Histidine kinase
K4A87_03850	COG4181	ATPase activity
K4A87_03895	COG1560	Kdo2-lipid A biosynthetic process
K4A87_03900	COG1519	Transferase
K4A87_03905	COG1538	Outer membrane efflux protein
K4A87_03910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K4A87_03925	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K4A87_03930	COG0066	3-isopropylmalate dehydratase activity
K4A87_03935	COG0473	3-isopropylmalate dehydrogenase activity
K4A87_03955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K4A87_03975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K4A87_03980	COG0840	transmembrane signaling receptor activity
K4A87_04005	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K4A87_04035	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K4A87_04050	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K4A87_04070	COG0563	adenylate kinase activity
K4A87_04075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K4A87_04090	COG0671	phosphoesterase, PA-phosphatase related
K4A87_04110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K4A87_04115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K4A87_04120	COG0352	thiamine-phosphate diphosphorylase activity
K4A87_04125	COG1773	rubredoxin
K4A87_04135	COG2912	Transglutaminase-like superfamily
K4A87_04155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K4A87_04180	COG0006	proline dipeptidase activity
K4A87_04185	COG0006	proline dipeptidase activity
K4A87_04200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K4A87_04205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K4A87_04210	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K4A87_04215	COG1561	YicC-like family, N-terminal region
K4A87_04230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K4A87_04240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K4A87_04265	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K4A87_04295	COG3385	transposase activity
K4A87_04335	COG0714	Associated with various cellular activities
K4A87_04355	COG2304	oxidoreductase activity
K4A87_04365	COG1301	dicarboxylic acid transport
K4A87_04380	COG0739	heme binding
K4A87_04385	COG1376	ErfK ybiS ycfS ynhG family protein
K4A87_04405	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K4A87_04410	COG4149	molybdate abc transporter
K4A87_04415	COG0725	ABC transporter, periplasmic molybdate-binding protein
K4A87_04420	COG3453	Protein conserved in bacteria
K4A87_04420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4A87_04430	COG3047	cAMP biosynthetic process
K4A87_04435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K4A87_04455	COG0469	pyruvate kinase activity
K4A87_04460	COG3588	fructose-bisphosphate aldolase
K4A87_04465	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K4A87_04480	COG0583	DNA-binding transcription factor activity
K4A87_04490	COG2205	protein histidine kinase activity
K4A87_04490	COG2198	Histidine kinase
K4A87_04490	COG0784	Response regulator, receiver
K4A87_04515	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K4A87_04520	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K4A87_04530	COG2895	sulfate adenylyltransferase (ATP) activity
K4A87_04530	COG0529	Catalyzes the synthesis of activated sulfate
K4A87_04535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K4A87_04540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K4A87_04550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K4A87_04565	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K4A87_04585	COG1217	gtp-binding protein TYPA
K4A87_04590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K4A87_04625	COG1902	pentaerythritol trinitrate reductase activity
K4A87_04625	COG0446	pyridine nucleotide-disulphide oxidoreductase
K4A87_04630	COG0604	alcohol dehydrogenase
K4A87_04660	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
K4A87_04665	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K4A87_04670	COG4208	sulfate ABC transporter
K4A87_04675	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K4A87_04705	COG0406	alpha-ribazole phosphatase activity
K4A87_04735	COG0189	ligase activity
K4A87_04740	COG0745	RESPONSE REGULATOR receiver
K4A87_04785	COG0237	dephospho-CoA kinase activity
K4A87_04790	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K4A87_04815	COG2184	nucleotidyltransferase activity
K4A87_04835	COG0045	succinate-CoA ligase (ADP-forming) activity
K4A87_04840	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K4A87_04850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K4A87_04850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K4A87_04855	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K4A87_04860	COG0564	pseudouridine synthase activity
K4A87_04865	COG1496	oxidoreductase activity
K4A87_04875	COG3387	PFAM Glycoside hydrolase 15-related
K4A87_04880	COG1877	trehalose-phosphatase activity
K4A87_04935	COG0542	response to heat
K4A87_04945	COG0019	diaminopimelate decarboxylase activity
K4A87_04960	COG4264	IucA IucC family
K4A87_04970	COG4772	TonB-dependent receptor
K4A87_04995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K4A87_04995	COG4651	solute:proton antiporter activity
K4A87_05020	COG0488	(ABC) transporter
K4A87_05040	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K4A87_05080	COG2255	four-way junction helicase activity
K4A87_05085	COG0824	Thioesterase
K4A87_05095	COG0848	biopolymer transport protein
K4A87_05105	COG0823	Involved in the tonB-independent uptake of proteins
K4A87_05110	COG2885	chlorophyll binding
K4A87_05120	COG0602	queuosine metabolic process
K4A87_05125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K4A87_05155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K4A87_05165	COG0544	peptidyl-prolyl cis-trans isomerase activity
K4A87_05190	COG2207	Transcriptional regulator
K4A87_05190	COG1917	Cupin 2, conserved barrel domain protein
K4A87_05195	COG0753	catalase activity
K4A87_05200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K4A87_05200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K4A87_05220	COG2194	sulfuric ester hydrolase activity
K4A87_05240	COG0642	Histidine kinase
K4A87_05250	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K4A87_05255	COG2894	cell division
K4A87_05260	COG0850	regulation of cytokinetic process
K4A87_05275	COG4585	Histidine kinase
K4A87_05280	COG2197	response regulator
K4A87_05295	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K4A87_05350	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K4A87_05365	COG1946	Acyl-CoA thioesterase
K4A87_05370	COG1024	Enoyl-CoA hydratase
K4A87_05380	COG0824	Thioesterase
K4A87_05385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K4A87_05395	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K4A87_05400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K4A87_05415	COG0196	riboflavin kinase activity
K4A87_05425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K4A87_05430	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K4A87_05445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K4A87_05450	COG1845	cytochrome c oxidase, subunit III
K4A87_05455	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K4A87_05495	COG2207	Transcriptional regulator
K4A87_05505	COG4771	TonB-dependent receptor
K4A87_05525	COG4191	Histidine kinase
K4A87_05525	COG0784	Response regulator, receiver
K4A87_05560	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K4A87_05570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K4A87_05575	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K4A87_05595	COG1842	Phage shock protein A
K4A87_05615	COG5463	Belongs to the UPF0441 family
K4A87_05620	COG0754	glutathionylspermidine amidase activity
K4A87_05670	COG0531	amino acid
K4A87_05675	COG2197	response regulator
K4A87_05690	COG1113	amino acid transport
K4A87_05725	COG2239	Acts as a magnesium transporter
K4A87_05730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K4A87_05735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4A87_05755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4A87_05770	COG1137	ATPase activity
K4A87_05775	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K4A87_05785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K4A87_05795	COG0271	Belongs to the BolA IbaG family
K4A87_05800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K4A87_05830	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K4A87_05835	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K4A87_05845	COG0628	permease
K4A87_05860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K4A87_05865	COG3178	'Phosphotransferase
K4A87_05880	COG1555	photosystem II stabilization
K4A87_05895	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K4A87_05900	COG1477	protein flavinylation
K4A87_05925	COG3128	pkhd-type hydroxylase
K4A87_05930	COG4774	siderophore transport
K4A87_05940	COG0456	acetyltransferase
K4A87_05950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K4A87_05955	COG0719	Fe-S assembly protein
K4A87_05960	COG0396	ATPase activity
K4A87_05965	COG0719	Fe-S assembly protein
K4A87_05970	COG1959	2 iron, 2 sulfur cluster binding
K4A87_05995	COG4942	peptidase
K4A87_06010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K4A87_06030	COG1678	Uncharacterized ACR, COG1678
K4A87_06035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K4A87_06045	COG1764	response to oxidative stress
K4A87_06055	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_06060	COG0384	phenazine biosynthesis protein PhzF
K4A87_06070	COG0527	aspartate kinase activity
K4A87_06095	COG0142	geranyltranstransferase activity
K4A87_06100	COG0629	single-stranded DNA binding
K4A87_06105	COG2203	Gaf domain
K4A87_06105	COG3706	GGDEF domain
K4A87_06105	COG4251	negative regulation of phosphorylation
K4A87_06105	COG5001	Diguanylate cyclase
K4A87_06115	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K4A87_06125	COG0746	molybdenum cofactor guanylyltransferase activity
K4A87_06135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K4A87_06140	COG2879	small protein
K4A87_06145	COG1966	Carbon starvation protein
K4A87_06165	COG0588	phosphoglycerate mutase activity
K4A87_06205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K4A87_06210	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K4A87_06225	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K4A87_06280	COG0438	transferase activity, transferring glycosyl groups
K4A87_06285	COG0438	transferase activity, transferring glycosyl groups
K4A87_06295	COG0438	transferase activity, transferring glycosyl groups
K4A87_06325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K4A87_06335	COG1960	acyl-CoA dehydrogenase activity
K4A87_06345	COG3040	lipid binding
K4A87_06360	COG3039	Transposase
K4A87_06405	COG0326	Molecular chaperone. Has ATPase activity
K4A87_06410	COG0742	ribosomal rna small subunit methyltransferase
K4A87_06415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K4A87_06425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K4A87_06430	COG0405	Gamma-glutamyltransferase
K4A87_06435	COG3291	Pkd domain containing protein
K4A87_06480	COG3039	Transposase
K4A87_06630	COG2963	transposase activity
K4A87_06655	COG0784	Response regulator, receiver
K4A87_06655	COG2205	protein histidine kinase activity
K4A87_06655	COG5002	protein histidine kinase activity
K4A87_06660	COG2733	membrane
K4A87_06670	COG1121	(ABC) transporter
K4A87_06675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K4A87_06685	COG2223	nitrite transmembrane transporter activity
K4A87_06690	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K4A87_06695	COG0243	molybdopterin cofactor binding
K4A87_06705	COG0477	Major facilitator Superfamily
K4A87_06715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K4A87_06720	COG0174	glutamine synthetase
K4A87_06760	COG3842	ATPase activity
K4A87_06765	COG1176	ABC-type spermidine putrescine transport system, permease component I
K4A87_06770	COG1177	transmembrane transport
K4A87_06775	COG1012	belongs to the aldehyde dehydrogenase family
K4A87_06795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K4A87_06800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K4A87_06810	COG2902	Dehydrogenase
K4A87_06880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K4A87_06930	COG4133	protoheme IX ABC transporter activity
K4A87_06935	COG0436	Aminotransferase
K4A87_06960	COG1187	pseudouridine synthase activity
K4A87_06965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K4A87_06970	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K4A87_06975	COG2350	Protein conserved in bacteria
K4A87_07010	COG1175	transmembrane transport
K4A87_07015	COG0395	ABC-type sugar transport system, permease component
K4A87_07040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K4A87_07045	COG2957	Belongs to the agmatine deiminase family
K4A87_07055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K4A87_07060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K4A87_07065	COG0539	negative regulation of cytoplasmic translation
K4A87_07080	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K4A87_07085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K4A87_07110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K4A87_07160	COG4691	Plasmid stability protein
K4A87_07165	COG1487	ribonuclease activity
K4A87_07180	COG3039	Transposase
K4A87_07190	COG3737	Protein of unknown function (DUF498/DUF598)
K4A87_07195	COG1534	Rna-binding protein
K4A87_07200	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K4A87_07210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K4A87_07215	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K4A87_07225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K4A87_07230	COG1546	Belongs to the CinA family
K4A87_07250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K4A87_07255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K4A87_07265	COG2137	regulation of response to DNA damage stimulus
K4A87_07270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K4A87_07275	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K4A87_07290	COG1741	Belongs to the pirin family
K4A87_07295	COG0583	DNA-binding transcription factor activity
K4A87_07320	COG0351	phosphomethylpyrimidine kinase
K4A87_07320	COG0352	thiamine-phosphate diphosphorylase activity
K4A87_07330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K4A87_07335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K4A87_07350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K4A87_07360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K4A87_07365	COG3734	2-keto-3-deoxy-galactonokinase
K4A87_07375	COG4948	Mandelate Racemase Muconate Lactonizing
K4A87_07380	COG0800	Aldolase
K4A87_07435	COG1501	Belongs to the glycosyl hydrolase 31 family
K4A87_07445	COG1070	Carbohydrate kinase
K4A87_07455	COG0477	Major facilitator Superfamily
K4A87_07480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K4A87_07485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K4A87_07490	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K4A87_07495	COG0166	Belongs to the GPI family
K4A87_07540	COG1472	Belongs to the glycosyl hydrolase 3 family
K4A87_07580	COG5001	Diguanylate cyclase
K4A87_07580	COG4251	negative regulation of phosphorylation
K4A87_07580	COG3706	GGDEF domain
K4A87_07580	COG2203	Gaf domain
K4A87_07600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K4A87_07605	COG0671	phosphoesterase, PA-phosphatase related
K4A87_07615	COG0697	spore germination
K4A87_07620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K4A87_07625	COG0167	dihydroorotate dehydrogenase activity
K4A87_07640	COG1012	belongs to the aldehyde dehydrogenase family
K4A87_07705	COG2003	Belongs to the UPF0758 family
K4A87_07825	COG2814	Major facilitator Superfamily
K4A87_07885	COG0527	aspartate kinase activity
K4A87_07885	COG0460	homoserine dehydrogenase
K4A87_07920	COG0124	histidyl-tRNA synthetase
K4A87_07930	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K4A87_07935	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K4A87_07940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K4A87_07945	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K4A87_07945	COG0131	Imidazoleglycerol-phosphate dehydratase
K4A87_07950	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K4A87_07955	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K4A87_07960	COG0107	imidazoleglycerol-phosphate synthase activity
K4A87_07965	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K4A87_07965	COG0140	phosphoribosyl-ATP diphosphatase activity
K4A87_08005	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
K4A87_08010	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K4A87_08020	COG0531	amino acid
K4A87_08025	COG0531	amino acid
K4A87_08035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K4A87_08040	COG0277	FAD linked oxidase domain protein
K4A87_08055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K4A87_08070	COG1024	Enoyl-CoA hydratase
K4A87_08105	COG0505	Belongs to the CarA family
K4A87_08120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K4A87_08125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K4A87_08135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K4A87_08155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K4A87_08170	COG2205	protein histidine kinase activity
K4A87_08170	COG0784	Response regulator, receiver
K4A87_08170	COG2198	Histidine kinase
K4A87_08175	COG1024	Enoyl-CoA hydratase
K4A87_08185	COG0318	PFAM AMP-dependent synthetase and ligase
K4A87_08215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K4A87_08245	COG0835	chemotaxis
K4A87_08260	COG0840	transmembrane signaling receptor activity
K4A87_08270	COG0840	transmembrane signaling receptor activity
K4A87_08280	COG0840	transmembrane signaling receptor activity
K4A87_08290	COG0840	transmembrane signaling receptor activity
K4A87_08295	COG0840	transmembrane signaling receptor activity
K4A87_08320	COG0643	Histidine kinase
K4A87_08320	COG2198	Histidine kinase
K4A87_08325	COG0745	RESPONSE REGULATOR receiver
K4A87_08335	COG0835	chemotaxis
K4A87_08340	COG1192	Involved in chromosome partitioning
K4A87_08345	COG1360	Flagellar Motor Protein
K4A87_08350	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K4A87_08370	COG2198	Histidine kinase
K4A87_08370	COG0784	Response regulator, receiver
K4A87_08370	COG0643	Histidine kinase
K4A87_08415	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_08455	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K4A87_08475	COG1684	flagellar biosynthetic protein fliR
K4A87_08550	COG1677	Flagellar hook-basal body complex protein FliE
K4A87_08575	COG2201	protein-glutamate methylesterase activity
K4A87_08585	COG2197	response regulator
K4A87_08605	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K4A87_08610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K4A87_08625	COG1705	Flagellar rod assembly protein muramidase FlgJ
K4A87_08625	COG3951	Flagellar rod assembly protein muramidase FlgJ
K4A87_08630	COG1706	bacterial-type flagellum-dependent cell motility
K4A87_08645	COG4787	bacterial-type flagellum-dependent cell motility
K4A87_08655	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K4A87_08660	COG1558	bacterial-type flagellum-dependent cell motility
K4A87_08675	COG0784	Response regulator, receiver
K4A87_08675	COG0835	chemotaxis
K4A87_08695	COG5002	protein histidine kinase activity
K4A87_08710	COG4585	Histidine kinase
K4A87_08735	COG2915	High frequency lysogenization protein hflD homolog
K4A87_08740	COG0482	sulfurtransferase activity
K4A87_08760	COG0542	response to heat
K4A87_08770	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K4A87_08780	COG0492	ferredoxin-NADP+ reductase activity
K4A87_08785	COG1674	ftsk spoiiie
K4A87_08800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K4A87_08805	COG0038	chloride channel
K4A87_08810	COG0183	Belongs to the thiolase family
K4A87_08815	COG1250	3-hydroxyacyl-CoA dehydrogenase
K4A87_08815	COG1024	Enoyl-CoA hydratase
K4A87_08830	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K4A87_08850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K4A87_08855	COG1160	GTP binding
K4A87_08860	COG0303	'Molybdopterin
K4A87_08865	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K4A87_08885	COG0303	'Molybdopterin
K4A87_08890	COG0746	molybdenum cofactor guanylyltransferase activity
K4A87_08900	COG1648	precorrin-2 dehydrogenase activity
K4A87_08900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K4A87_08915	COG3685	Protein conserved in bacteria
K4A87_08970	COG1064	alcohol dehydrogenase
K4A87_09210	COG2154	pterin-4-alpha-carbinolamine dehydratase
K4A87_09230	COG0564	pseudouridine synthase activity
K4A87_09235	COG1530	ribonuclease E activity
K4A87_09255	COG1304	FMN binding
K4A87_09265	COG1657	PFAM Prenyltransferase squalene oxidase
K4A87_09270	COG0142	geranyltranstransferase activity
K4A87_09275	COG2124	cytochrome p450
K4A87_09280	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_09285	COG1141	Ferredoxin
K4A87_09290	COG2124	cytochrome p450
K4A87_09295	COG2124	cytochrome p450
K4A87_09300	COG2124	cytochrome p450
K4A87_09315	COG2951	lytic endotransglycosylase activity
K4A87_09330	COG1054	Belongs to the UPF0176 family
K4A87_09355	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K4A87_09375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4A87_09410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K4A87_09415	COG0322	excinuclease ABC activity
K4A87_09425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K4A87_09430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K4A87_09435	COG1663	tetraacyldisaccharide 4'-kinase activity
K4A87_09440	COG1132	(ABC) transporter
K4A87_09445	COG0848	biopolymer transport protein
K4A87_09450	COG0811	peptide transport
K4A87_09465	COG1136	(ABC) transporter
K4A87_09470	COG4591	ABC-type transport system involved in lipoprotein release permease component
K4A87_09480	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K4A87_09485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K4A87_09495	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K4A87_09520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K4A87_09535	COG0129	dihydroxy-acid dehydratase activity
K4A87_09540	COG0800	Aldolase
K4A87_09605	COG0784	Response regulator, receiver
K4A87_09605	COG2198	Histidine kinase
K4A87_09605	COG2205	protein histidine kinase activity
K4A87_09610	COG2183	response to ionizing radiation
K4A87_09635	COG3243	poly(R)-hydroxyalkanoic acid synthase
K4A87_09670	COG0668	transmembrane transport
K4A87_09690	COG1914	H( )-stimulated, divalent metal cation uptake system
K4A87_09730	COG1238	metal cluster binding
K4A87_09735	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K4A87_09740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K4A87_09745	COG2840	Smr protein MutS2
K4A87_09755	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K4A87_09760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K4A87_09770	COG0148	phosphopyruvate hydratase activity
K4A87_09775	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K4A87_09780	COG0504	CTP synthase activity
K4A87_09800	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K4A87_09815	COG1253	flavin adenine dinucleotide binding
K4A87_09830	COG2271	Major facilitator Superfamily
K4A87_09885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4A87_09910	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
K4A87_09925	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K4A87_09930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K4A87_09935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K4A87_09945	COG2890	protein-(glutamine-N5) methyltransferase activity
K4A87_10000	COG1228	amidohydrolase
K4A87_10005	COG2986	histidine ammonia-lyase
K4A87_10015	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K4A87_10040	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K4A87_10055	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K4A87_10060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K4A87_10095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K4A87_10105	COG0316	Belongs to the HesB IscA family
K4A87_10110	COG0017	Asparaginyl-tRNA synthetase
K4A87_10135	COG0288	reversible hydration of carbon dioxide
K4A87_10150	COG3844	kynureninase activity
K4A87_10155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K4A87_10160	COG2925	Exonuclease
K4A87_10180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K4A87_10185	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K4A87_10185	COG0116	Belongs to the methyltransferase superfamily
K4A87_10225	COG0494	nUDIX hydrolase
K4A87_10245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K4A87_10250	COG0659	secondary active sulfate transmembrane transporter activity
K4A87_10280	COG0573	inorganic phosphate transmembrane transporter activity
K4A87_10285	COG0581	inorganic phosphate transmembrane transporter activity
K4A87_10290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K4A87_10295	COG0704	Plays a role in the regulation of phosphate uptake
K4A87_10300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K4A87_10315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K4A87_10320	COG0557	exoribonuclease II activity
K4A87_10330	COG1960	acyl-CoA dehydrogenase activity
K4A87_10335	COG2226	methyltransferase
K4A87_10340	COG0646	methionine synthase
K4A87_10340	COG1410	methionine synthase
K4A87_10345	COG0646	methionine synthase
K4A87_10345	COG1410	methionine synthase
K4A87_10355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K4A87_10365	COG1609	Transcriptional regulator
K4A87_10380	COG2900	Belongs to the SlyX family
K4A87_10395	COG0386	Belongs to the glutathione peroxidase family
K4A87_10405	COG1725	Transcriptional regulator
K4A87_10410	COG1131	(ABC) transporter
K4A87_10470	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_10480	COG2850	peptidyl-arginine hydroxylation
K4A87_10515	COG1132	(ABC) transporter
K4A87_10555	COG1605	Chorismate mutase
K4A87_10555	COG0287	Prephenate dehydrogenase
K4A87_10560	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K4A87_10565	COG0484	heat shock protein binding
K4A87_10575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K4A87_10585	COG0497	DNA recombination
K4A87_10595	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K4A87_10600	COG2914	Belongs to the UPF0125 (RnfH) family
K4A87_10610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K4A87_10760	COG3702	type iv secretory pathway
K4A87_10780	COG2948	multi-organism process
K4A87_10810	COG0556	nucleotide-excision repair
K4A87_10885	COG0165	Argininosuccinate lyase
K4A87_10900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K4A87_10905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K4A87_10910	COG0137	argininosuccinate synthase activity
K4A87_10915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K4A87_10930	COG2166	iron-sulfur cluster assembly
K4A87_10955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K4A87_10995	COG0402	S-adenosylhomocysteine deaminase activity
K4A87_11010	COG1509	lysine 2,3-aminomutase activity
K4A87_11020	COG0483	inositol monophosphate 1-phosphatase activity
K4A87_11025	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K4A87_11040	COG0488	(ABC) transporter
K4A87_11045	COG0513	Belongs to the DEAD box helicase family
K4A87_11050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K4A87_11055	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K4A87_11065	COG0625	glutathione transferase activity
K4A87_11075	COG4681	YaeQ
K4A87_11080	COG2081	HI0933 family
K4A87_11090	COG0501	Belongs to the peptidase M48B family
K4A87_11095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K4A87_11100	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_11120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K4A87_11125	COG0860	N-Acetylmuramoyl-L-alanine amidase
K4A87_11135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K4A87_11135	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K4A87_11140	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K4A87_11155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K4A87_11190	COG2094	Belongs to the DNA glycosylase MPG family
K4A87_11205	COG2969	positive regulation of protein catabolic process
K4A87_11210	COG0625	glutathione transferase activity
K4A87_11215	COG2857	Cytochrome c1
K4A87_11220	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K4A87_11225	COG0723	plastoquinol--plastocyanin reductase activity
K4A87_11230	COG0741	lytic transglycosylase activity
K4A87_11260	COG0415	Belongs to the DNA photolyase family
K4A87_11265	COG0305	Participates in initiation and elongation during chromosome replication
K4A87_11275	COG0367	asparagine synthase
K4A87_11310	COG0084	hydrolase, TatD family'
K4A87_11315	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K4A87_11380	COG0386	Belongs to the glutathione peroxidase family
K4A87_11440	COG2814	Major facilitator Superfamily
K4A87_11445	COG1566	PFAM secretion protein HlyD family protein
K4A87_11490	COG0367	asparagine synthase
K4A87_11495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K4A87_11505	COG1393	Belongs to the ArsC family
K4A87_11520	COG0024	Methionine aminopeptidase
K4A87_11555	COG0052	Belongs to the universal ribosomal protein uS2 family
K4A87_11560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K4A87_11570	COG0528	UMP kinase activity
K4A87_11575	COG0233	cytoplasmic translational termination
K4A87_11585	COG0575	Belongs to the CDS family
K4A87_11590	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K4A87_11595	COG0750	zinc metalloprotease
K4A87_11610	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K4A87_11620	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K4A87_11625	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K4A87_11640	COG0825	malonyl-CoA metabolic process
K4A87_11645	COG1981	membrane
K4A87_11675	COG5599	Phosphatase
K4A87_11695	COG3039	Transposase
K4A87_11765	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_11790	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K4A87_11820	COG0531	amino acid
K4A87_11835	COG0006	proline dipeptidase activity
K4A87_11845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K4A87_11860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K4A87_11865	COG3938	Belongs to the proline racemase family
K4A87_11875	COG0552	protein localization to endoplasmic reticulum
K4A87_11890	COG3039	Transposase
K4A87_11950	COG0583	DNA-binding transcription factor activity
K4A87_11975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K4A87_11980	COG1605	Chorismate mutase
K4A87_11980	COG0077	Prephenate dehydratase
K4A87_11985	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K4A87_11990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K4A87_12000	COG1609	Transcriptional regulator
K4A87_12005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K4A87_12005	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4A87_12010	COG1105	Belongs to the carbohydrate kinase PfkB family
K4A87_12015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K4A87_12015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K4A87_12030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K4A87_12035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K4A87_12040	COG1862	Preprotein translocase
K4A87_12050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K4A87_12075	COG1702	phosphate starvation-inducible protein PhoH
K4A87_12080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K4A87_12090	COG4535	Mg2 and Co2 transporter CorC
K4A87_12115	COG2003	Belongs to the UPF0758 family
K4A87_12120	COG0688	phosphatidylethanolamine metabolic process
K4A87_12130	COG3220	belongs to the UPF0276 family
K4A87_12145	COG0840	transmembrane signaling receptor activity
K4A87_12185	COG4968	Prepilin-type N-terminal cleavage methylation domain
K4A87_12190	COG3275	phosphorelay sensor kinase activity
K4A87_12205	COG1611	Belongs to the LOG family
K4A87_12215	COG2095	MarC family integral membrane protein
K4A87_12225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K4A87_12270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K4A87_12280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K4A87_12285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K4A87_12290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K4A87_12295	COG0195	Participates in both transcription termination and antitermination
K4A87_12300	COG0779	Required for maturation of 30S ribosomal subunits
K4A87_12310	COG1007	ATP synthesis coupled electron transport
K4A87_12335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K4A87_12350	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K4A87_12355	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K4A87_12360	COG0649	NAD binding
K4A87_12365	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K4A87_12375	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K4A87_12425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K4A87_12445	COG0133	tryptophan synthase activity
K4A87_12465	COG0101	tRNA pseudouridine synthase activity
K4A87_12485	COG0433	COG0433 Predicted ATPase
K4A87_12500	COG5487	UPF0391 membrane protein
K4A87_12530	COG0183	Belongs to the thiolase family
K4A87_12560	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K4A87_12560	COG1793	dna ligase
K4A87_12570	COG1793	dna ligase
K4A87_12575	COG1201	RNA secondary structure unwinding
K4A87_12585	COG1278	Cold shock
K4A87_12590	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K4A87_12595	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K4A87_12600	COG1472	Belongs to the glycosyl hydrolase 3 family
K4A87_12605	COG3046	protein related to deoxyribodipyrimidine photolyase
K4A87_12610	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
K4A87_12615	COG2954	triphosphatase activity
K4A87_12630	COG1381	Involved in DNA repair and RecF pathway recombination
K4A87_12645	COG0571	ribonuclease III activity
K4A87_12660	COG0481	GTPase activity
K4A87_12675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K4A87_12690	COG1024	Enoyl-CoA hydratase
K4A87_12690	COG1250	3-hydroxyacyl-CoA dehydrogenase
K4A87_12705	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K4A87_12710	COG1024	Enoyl-CoA hydratase
K4A87_12715	COG1960	acyl-CoA dehydrogenase activity
K4A87_12785	COG2198	Histidine kinase
K4A87_12785	COG0643	Histidine kinase
K4A87_12795	COG0835	chemotaxis
K4A87_12800	COG2199	diguanylate cyclase activity
K4A87_12800	COG2200	EAL domain
K4A87_12800	COG2202	Pas domain
K4A87_12805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K4A87_12845	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K4A87_12860	COG2040	homocysteine
K4A87_12865	COG0833	amino acid
K4A87_12880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K4A87_12880	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K4A87_12890	COG2878	Part of a membrane complex involved in electron transport
K4A87_12905	COG1595	DNA-templated transcription, initiation
K4A87_12930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K4A87_12945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K4A87_12955	COG0251	oxidation-reduction process
K4A87_12960	COG0392	lysyltransferase activity
K4A87_12960	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K4A87_12990	COG2814	Major facilitator Superfamily
K4A87_13030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K4A87_13055	COG0412	Dienelactone hydrolase
K4A87_13070	COG0717	Belongs to the dCTP deaminase family
K4A87_13075	COG0489	protein tyrosine kinase activity
K4A87_13110	COG3590	peptidase
K4A87_13145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K4A87_13150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K4A87_13155	COG2311	Membrane
K4A87_13160	COG1047	Peptidyl-prolyl cis-trans
K4A87_13165	COG0791	NLP P60 protein
K4A87_13170	COG0791	NLP P60 protein
K4A87_13185	COG1301	dicarboxylic acid transport
K4A87_13190	COG1785	Belongs to the alkaline phosphatase family
K4A87_13195	COG0037	tRNA processing
K4A87_13200	COG1722	exodeoxyribonuclease VII activity
K4A87_13205	COG0142	geranyltranstransferase activity
K4A87_13220	COG0312	modulator of DNA gyrase
K4A87_13225	COG3028	Belongs to the UPF0307 family
K4A87_13230	COG0312	modulator of DNA gyrase
K4A87_13240	COG3164	Protein of unknown function
K4A87_13250	COG0424	maF-like protein
K4A87_13255	COG2968	Membrane
K4A87_13290	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K4A87_13305	COG0495	leucyl-tRNA aminoacylation
K4A87_13315	COG3118	belongs to the thioredoxin family
K4A87_13385	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K4A87_13440	COG5297	Belongs to the glycosyl hydrolase family 6
K4A87_13465	COG2155	Conserved Protein
K4A87_13500	COG1132	(ABC) transporter
K4A87_13510	COG0475	glutathione-regulated potassium exporter activity
K4A87_13535	COG1187	pseudouridine synthase activity
K4A87_13545	COG5002	protein histidine kinase activity
K4A87_13545	COG5001	Diguanylate cyclase
K4A87_13630	COG1404	Belongs to the peptidase S8 family
K4A87_13660	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K4A87_13665	COG0735	belongs to the Fur family
K4A87_13670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K4A87_13700	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K4A87_13710	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K4A87_13755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K4A87_13765	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K4A87_13780	COG0534	Mate efflux family protein
K4A87_13790	COG0336	Belongs to the RNA methyltransferase TrmD family
K4A87_13795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K4A87_13820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K4A87_13825	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K4A87_13850	COG2353	YceI-like domain
K4A87_13880	COG0460	homoserine dehydrogenase
K4A87_13880	COG0527	aspartate kinase activity
K4A87_13885	COG0626	cystathionine gamma-synthase activity
K4A87_13890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K4A87_13900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K4A87_13905	COG1272	protein, Hemolysin III
K4A87_13910	COG2982	Protein involved in outer membrane biogenesis
K4A87_13915	COG0516	GMP reductase activity
K4A87_13915	COG0517	IMP dehydrogenase activity
K4A87_13920	COG0463	Glycosyl transferase, family 2
K4A87_13925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K4A87_13930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K4A87_13940	COG1309	transcriptional regulator
K4A87_13950	COG1960	acyl-CoA dehydrogenase activity
K4A87_13980	COG0509	glycine decarboxylation via glycine cleavage system
K4A87_13985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K4A87_13995	COG3956	TIGRFAM MazG family protein
K4A87_14000	COG1218	3'(2'),5'-bisphosphate nucleotidase
K4A87_14005	COG0494	nUDIX hydrolase
K4A87_14015	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K4A87_14055	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K4A87_14065	COG1309	transcriptional regulator
K4A87_14090	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_14130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K4A87_14140	COG0330	HflC and HflK could
K4A87_14145	COG0330	HflC and HflK could
K4A87_14170	COG0678	peroxiredoxin activity
K4A87_14195	COG0346	lactoylglutathione lyase activity
K4A87_14220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K4A87_14225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K4A87_14250	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_14285	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K4A87_14300	COG3829	transcription factor binding
K4A87_14335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K4A87_14340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K4A87_14355	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_14360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K4A87_14365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K4A87_14375	COG1399	metal-binding, possibly nucleic acid-binding protein
K4A87_14380	COG0424	maF-like protein
K4A87_14400	COG0714	Associated with various cellular activities
K4A87_14420	COG0537	adenosine 5'-monophosphoramidase activity
K4A87_14430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K4A87_14520	COG0314	molybdopterin synthase activity
K4A87_14530	COG0315	cyclic pyranopterin monophosphate synthase activity
K4A87_14540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K4A87_14545	COG1234	tRNA 3'-trailer cleavage
K4A87_14550	COG3642	lipopolysaccharide core region biosynthetic process
K4A87_14555	COG0859	PFAM glycosyl transferase family 9
K4A87_14570	COG0631	protein serine/threonine phosphatase activity
K4A87_14580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K4A87_14595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4A87_14600	COG3942	CHAP domain
K4A87_14600	COG1388	LysM domain
K4A87_14610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K4A87_14615	COG3039	Transposase
K4A87_14625	COG0823	Involved in the tonB-independent uptake of proteins
K4A87_14625	COG1506	peptidase
K4A87_14655	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_14685	COG1297	OPT oligopeptide transporter protein
K4A87_14710	COG2080	2 iron, 2 sulfur cluster binding
K4A87_14715	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K4A87_14720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K4A87_14725	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_14775	COG0837	glucose binding
K4A87_14795	COG1388	LysM domain
K4A87_14795	COG3858	chitin binding
K4A87_14800	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K4A87_14810	COG1472	Belongs to the glycosyl hydrolase 3 family
K4A87_14860	COG3537	Alpha-1,2-mannosidase
K4A87_14915	COG3645	SOS response
K4A87_14930	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K4A87_14965	COG3142	Participates in the control of copper homeostasis
K4A87_14990	COG2201	protein-glutamate methylesterase activity
K4A87_15000	COG0840	transmembrane signaling receptor activity
K4A87_15005	COG0835	chemotaxis
K4A87_15020	COG0189	ligase activity
K4A87_15040	COG1199	ATP-dependent helicase activity
K4A87_15050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K4A87_15055	COG1215	transferase activity, transferring glycosyl groups
K4A87_15065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K4A87_15075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K4A87_15080	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
K4A87_15090	COG0535	radical SAM domain protein
K4A87_15115	COG1643	Atp-dependent helicase
K4A87_15120	COG0783	Belongs to the Dps family
K4A87_15165	COG0860	N-Acetylmuramoyl-L-alanine amidase
K4A87_15200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K4A87_15260	COG0473	3-isopropylmalate dehydrogenase activity
K4A87_15275	COG4783	chaperone-mediated protein folding
K4A87_15295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K4A87_15305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K4A87_15305	COG0438	transferase activity, transferring glycosyl groups
K4A87_15310	COG0671	phosphoesterase, PA-phosphatase related
K4A87_15315	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K4A87_15330	COG2833	Protein of unknown function (DUF455)
K4A87_15350	COG0285	dihydrofolate synthase activity
K4A87_15370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K4A87_15415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K4A87_15420	COG0471	metal ion transport
K4A87_15420	COG3273	potassium ion transport
K4A87_15440	COG1970	mechanosensitive ion channel activity
K4A87_15470	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K4A87_15480	COG0203	ribosomal protein L17
K4A87_15505	COG0201	protein transport
K4A87_15510	COG0200	Binds to the 23S rRNA
K4A87_15515	COG1841	ribosomal large subunit assembly
K4A87_15550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K4A87_15560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K4A87_15565	COG0255	Belongs to the universal ribosomal protein uL29 family
K4A87_15580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K4A87_15590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K4A87_15605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K4A87_15610	COG0051	transcription antitermination factor activity, RNA binding
K4A87_15615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K4A87_15620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K4A87_15630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K4A87_15635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K4A87_15645	COG0222	ribosome binding
K4A87_15650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K4A87_15655	COG0081	regulation of translation
K4A87_15665	COG0250	Participates in transcription elongation, termination and antitermination
K4A87_15670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K4A87_15680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K4A87_15700	COG0012	GTP binding
K4A87_15705	COG0193	aminoacyl-tRNA hydrolase activity
K4A87_15710	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K4A87_15715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K4A87_15725	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K4A87_15730	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K4A87_15740	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K4A87_15745	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K4A87_15755	COG0521	Mo-molybdopterin cofactor biosynthetic process
K4A87_15775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4A87_15780	COG1295	ribonuclease BN
K4A87_15805	COG1404	Belongs to the peptidase S8 family
K4A87_15815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K4A87_15865	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K4A87_15865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K4A87_15885	COG2890	protein-(glutamine-N5) methyltransferase activity
K4A87_15895	COG3634	alkyl hydroperoxide reductase activity
K4A87_15900	COG0583	DNA-binding transcription factor activity
K4A87_15910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K4A87_15915	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K4A87_15930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K4A87_15950	COG0673	inositol 2-dehydrogenase activity
K4A87_15955	COG3386	PFAM SMP-30 Gluconolaconase
K4A87_15975	COG0583	DNA-binding transcription factor activity
K4A87_15990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K4A87_15995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K4A87_16005	COG2096	Adenosyltransferase
K4A87_16010	COG0123	including yeast histone deacetylase and acetoin utilization protein
K4A87_16015	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K4A87_16025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K4A87_16030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K4A87_16035	COG2967	ApaG domain
K4A87_16040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K4A87_16060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K4A87_16080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K4A87_16115	COG0281	malic enzyme
K4A87_16115	COG0280	phosphate acetyltransferase
K4A87_16185	COG0642	Histidine kinase
K4A87_16200	COG2851	Citrate transporter
K4A87_16205	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_16220	COG2211	Major facilitator Superfamily
K4A87_16270	COG0436	Aminotransferase
K4A87_16295	COG0726	polysaccharide deacetylase
K4A87_16300	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K4A87_16360	COG3920	Histidine kinase
K4A87_16365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K4A87_16370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K4A87_16375	COG1609	Transcriptional regulator
K4A87_16385	COG2188	Transcriptional regulator
K4A87_16455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K4A87_16460	COG4191	Histidine kinase
K4A87_16465	COG0784	Response regulator, receiver
K4A87_16470	COG4251	negative regulation of phosphorylation
K4A87_16480	COG2823	Periplasmic or secreted lipoprotein
K4A87_16485	COG0673	inositol 2-dehydrogenase activity
K4A87_16490	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K4A87_16585	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K4A87_16595	COG2921	Belongs to the UPF0250 family
K4A87_16605	COG1686	Belongs to the peptidase S11 family
K4A87_16610	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K4A87_16615	COG2951	lytic endotransglycosylase activity
K4A87_16625	COG0772	Belongs to the SEDS family
K4A87_16640	COG1792	Involved in formation and maintenance of cell shape
K4A87_16645	COG1077	Cell shape determining protein MreB Mrl
K4A87_16650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K4A87_16670	COG0308	aminopeptidase N
K4A87_16675	COG5001	Diguanylate cyclase
K4A87_16675	COG3300	MHYT domain
K4A87_16680	COG2226	methyltransferase
K4A87_16705	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K4A87_16710	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K4A87_16715	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K4A87_16725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K4A87_16735	COG2832	Protein of unknown function (DUF454)
K4A87_16765	COG0436	Aminotransferase
K4A87_16780	COG1505	serine-type exopeptidase activity
K4A87_16805	COG0181	hydroxymethylbilane synthase activity
K4A87_16825	COG2943	transferase activity, transferring hexosyl groups
K4A87_16840	COG0659	secondary active sulfate transmembrane transporter activity
K4A87_16845	COG5297	Belongs to the glycosyl hydrolase family 6
K4A87_16845	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K4A87_16900	COG1113	amino acid transport
K4A87_16905	COG4305	rare lipoprotein A
K4A87_16920	COG0697	spore germination
K4A87_17000	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K4A87_17005	COG0511	ligase activity, forming carbon-carbon bonds
K4A87_17015	COG0439	Biotin carboxylase
K4A87_17020	COG2264	protein methyltransferase activity
K4A87_17045	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K4A87_17065	COG0138	bifunctional purine biosynthesis protein purh
K4A87_17070	COG0151	Belongs to the GarS family
K4A87_17075	COG3039	Transposase
K4A87_17100	COG1289	transmembrane transporter activity
K4A87_17105	COG2814	Major facilitator Superfamily
K4A87_17115	COG2814	Major facilitator Superfamily
K4A87_17130	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K4A87_17135	COG2816	NAD+ diphosphatase activity
K4A87_17140	COG0316	Belongs to the HesB IscA family
K4A87_17200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K4A87_17210	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
K4A87_17225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K4A87_17235	COG0134	indole-3-glycerol-phosphate synthase activity
K4A87_17240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K4A87_17275	COG1597	lipid kinase activity
K4A87_17280	COG0456	acetyltransferase
K4A87_17295	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K4A87_17330	COG2111	Na H antiporter
K4A87_17330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K4A87_17335	COG1006	Multisubunit Na H antiporter MnhC subunit
K4A87_17340	COG0651	ATP synthesis coupled electron transport
K4A87_17350	COG2212	antiporter activity
K4A87_17355	COG1320	monovalent cation:proton antiporter activity
K4A87_17390	COG3023	N-Acetylmuramoyl-L-alanine amidase
K4A87_17400	COG4948	Mandelate Racemase Muconate Lactonizing
K4A87_17410	COG0531	amino acid
K4A87_17430	COG2133	pyrroloquinoline quinone binding
K4A87_17445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K4A87_17450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K4A87_17465	COG1295	ribonuclease BN
K4A87_17470	COG0358	DNA primase activity
K4A87_17475	COG0109	protoheme IX farnesyltransferase activity
K4A87_17505	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K4A87_17515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K4A87_17535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K4A87_17540	COG0739	heme binding
K4A87_17545	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K4A87_17555	COG2223	nitrite transmembrane transporter activity
K4A87_17565	COG0708	Exodeoxyribonuclease III
K4A87_17580	COG1192	Involved in chromosome partitioning
K4A87_17585	COG1475	DNA binding
K4A87_17600	COG0463	Glycosyl transferase, family 2
K4A87_17615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K4A87_17625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K4A87_17630	COG2003	Belongs to the UPF0758 family
K4A87_17635	COG0018	arginyl-trna synthetase
K4A87_17650	COG4221	oxidoreductase activity
K4A87_17655	COG1819	glycosyl
K4A87_17660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4A87_17670	COG1166	arginine decarboxylase activity
K4A87_17675	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K4A87_17700	COG3291	Pkd domain containing protein
K4A87_17700	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K4A87_17715	COG0606	chelatase, subunit chli
K4A87_17730	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K4A87_17790	COG2826	transposase and inactivated derivatives, IS30 family
K4A87_17810	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K4A87_17815	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K4A87_17815	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K4A87_17845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K4A87_17865	COG1199	ATP-dependent helicase activity
K4A87_17940	COG2816	NAD+ diphosphatase activity
K4A87_18025	COG1136	(ABC) transporter
K4A87_18025	COG0577	efflux transmembrane transporter activity
K4A87_18055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K4A87_18080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K4A87_18135	COG3039	Transposase
K4A87_18165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K4A87_18210	COG1272	protein, Hemolysin III
K4A87_18215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4A87_18230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K4A87_18235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K4A87_18255	COG2239	Acts as a magnesium transporter
K4A87_18260	COG3338	carbonate dehydratase activity
K4A87_18270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K4A87_18275	COG3387	PFAM Glycoside hydrolase 15-related
K4A87_18290	COG3100	YcgL domain-containing protein
K4A87_18295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K4A87_18305	COG0463	Glycosyl transferase, family 2
K4A87_18320	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_18345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K4A87_18360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K4A87_18415	COG1131	(ABC) transporter
K4A87_18495	COG0210	DNA helicase
K4A87_18505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K4A87_18540	COG2091	lysine biosynthetic process via aminoadipic acid
K4A87_18555	COG0708	Exodeoxyribonuclease III
K4A87_18565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K4A87_18570	COG3162	membrane
K4A87_18600	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_18605	COG0179	Fumarylacetoacetate (FAA) hydrolase
K4A87_18610	COG4948	Mandelate Racemase Muconate Lactonizing
K4A87_18615	COG3254	rhamnose metabolic process
K4A87_18620	COG0738	Major facilitator superfamily
K4A87_18625	COG1414	Transcriptional regulator
K4A87_18630	COG1971	Probably functions as a manganese efflux pump
K4A87_18670	COG0784	Response regulator, receiver
K4A87_18670	COG2205	protein histidine kinase activity
K4A87_18690	COG3459	Glycosyltransferase 36 associated
K4A87_18695	COG2211	Major facilitator Superfamily
K4A87_18700	COG3265	gluconokinase activity
K4A87_18705	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K4A87_18745	COG2911	Protein conserved in bacteria
K4A87_18750	COG0729	surface antigen
K4A87_18755	COG4771	TonB-dependent receptor
K4A87_18785	COG0009	L-threonylcarbamoyladenylate synthase
K4A87_18790	COG1754	DNA topoisomerase type I activity
K4A87_18790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K4A87_18800	COG0758	DNA mediated transformation
K4A87_18805	COG1652	LysM domain
K4A87_18810	COG0242	peptide deformylase activity
K4A87_18815	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K4A87_18820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K4A87_18820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K4A87_18825	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K4A87_18855	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K4A87_18870	COG1490	D-aminoacyl-tRNA deacylase activity
K4A87_18875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K4A87_18920	COG4555	ABC transporter
K4A87_18935	COG0633	Ferredoxin
K4A87_18935	COG0543	2 iron, 2 sulfur cluster binding
K4A87_18945	COG0842	Transport permease protein
K4A87_18955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K4A87_18970	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K4A87_19010	COG3104	oligopeptide transport
K4A87_19015	COG3483	tryptophan 2,3-dioxygenase activity
K4A87_19020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K4A87_19035	COG0508	dehydrogenase complex catalyzes the overall conversion of
K4A87_19060	COG0513	Belongs to the DEAD box helicase family
K4A87_19155	COG0676	glucose-6-phosphate 1-epimerase activity
K4A87_19170	COG0730	response to heat
K4A87_19195	COG0302	gtp cyclohydrolase
K4A87_19200	COG0477	Major facilitator Superfamily
K4A87_19240	COG3550	peptidyl-serine autophosphorylation
K4A87_19315	COG3549	Plasmid maintenance system killer
K4A87_19325	COG1074	ATP-dependent DNA helicase activity
K4A87_19330	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K4A87_19335	COG1127	ABC transporter
K4A87_19340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K4A87_19345	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K4A87_19360	COG2853	Lipoprotein
K4A87_19375	COG1322	Protein conserved in bacteria
K4A87_19390	COG0531	amino acid
K4A87_19395	COG2203	Gaf domain
K4A87_19395	COG2199	diguanylate cyclase activity
K4A87_19425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K4A87_19430	COG0861	Integral membrane protein TerC family
K4A87_19445	COG0604	alcohol dehydrogenase
K4A87_19445	COG1028	Short-chain dehydrogenase reductase Sdr
K4A87_19445	COG3321	synthase
K4A87_19450	COG2937	Belongs to the GPAT DAPAT family
K4A87_19485	COG0284	orotidine-5'-phosphate decarboxylase activity
K4A87_19495	COG3132	Protein of unknown function, DUF480
K4A87_19505	COG0210	DNA helicase
K4A87_19510	COG1435	thymidine kinase activity
K4A87_19515	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K4A87_19550	COG0706	membrane insertase activity
K4A87_19555	COG0594	ribonuclease P activity