locus-tag	class	description
MML47_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MML47_00020	COG0187	DNA topoisomerase II activity
MML47_00030	COG0501	Belongs to the peptidase M48B family
MML47_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MML47_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MML47_00105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MML47_00115	COG0793	Belongs to the peptidase S41A family
MML47_00120	COG4942	peptidase
MML47_00130	COG2234	aminopeptidase activity
MML47_00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MML47_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MML47_00165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MML47_00170	COG1064	alcohol dehydrogenase
MML47_00185	COG0493	'glutamate synthase
MML47_00190	COG0067	glutamate synthase
MML47_00190	COG0069	glutamate synthase activity
MML47_00190	COG0070	glutamate synthase
MML47_00250	COG1111	helicase
MML47_00250	COG1205	dead DEAH box helicase
MML47_00255	COG1272	protein, Hemolysin III
MML47_00275	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MML47_00285	COG4772	TonB-dependent receptor
MML47_00300	COG3039	Transposase
MML47_00305	COG1304	FMN binding
MML47_00310	COG1755	Isoprenylcysteine carboxyl methyltransferase
MML47_00340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MML47_00370	COG0477	Major facilitator Superfamily
MML47_00435	COG0656	L-ascorbic acid biosynthetic process
MML47_00440	COG2130	NADP-dependent
MML47_00445	COG0667	Aldo Keto reductase
MML47_00455	COG1187	pseudouridine synthase activity
MML47_00470	COG1643	Atp-dependent helicase
MML47_00480	COG4807	Protein conserved in bacteria
MML47_00485	COG2351	hydroxyisourate hydrolase activity
MML47_00510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MML47_00520	COG0583	DNA-binding transcription factor activity
MML47_00575	COG2911	Protein conserved in bacteria
MML47_00580	COG0729	surface antigen
MML47_00585	COG4771	TonB-dependent receptor
MML47_00590	COG0457	Tetratricopeptide repeat
MML47_00600	COG0752	glycyl-tRNA synthetase alpha subunit
MML47_00605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MML47_00615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MML47_00615	COG0519	Catalyzes the synthesis of GMP from XMP
MML47_00625	COG0805	protein transport
MML47_00630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MML47_00635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MML47_00645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MML47_00670	COG2974	May be involved in recombination
MML47_00675	COG0037	tRNA processing
MML47_00695	COG3661	Belongs to the glycosyl hydrolase 67 family
MML47_00705	COG4948	Mandelate Racemase Muconate Lactonizing
MML47_00715	COG1472	Belongs to the glycosyl hydrolase 3 family
MML47_00720	COG0246	Mannitol dehydrogenase
MML47_00755	COG1192	Involved in chromosome partitioning
MML47_00770	COG3237	CsbD-like
MML47_00830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MML47_00835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MML47_00850	COG0028	Belongs to the TPP enzyme family
MML47_00855	COG4191	Histidine kinase
MML47_00880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MML47_00895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MML47_00900	COG3177	Filamentation induced by cAMP protein fic
MML47_00905	COG0596	Alpha beta hydrolase
MML47_00910	COG0727	PFAM Uncharacterised protein family (UPF0153)
MML47_00915	COG0318	PFAM AMP-dependent synthetase and ligase
MML47_00920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MML47_00930	COG1181	Belongs to the D-alanine--D-alanine ligase family
MML47_00940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MML47_00955	COG0564	pseudouridine synthase activity
MML47_00985	COG0339	signal peptide processing
MML47_01030	COG4770	biotin carboxylase activity
MML47_01035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MML47_01040	COG1960	acyl-CoA dehydrogenase activity
MML47_01090	COG0523	cobalamin synthesis protein
MML47_01105	COG0697	spore germination
MML47_01115	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MML47_01120	COG1846	Transcriptional regulator
MML47_01125	COG1764	response to oxidative stress
MML47_01170	COG1199	ATP-dependent helicase activity
MML47_01260	COG0183	Belongs to the thiolase family
MML47_01270	COG3039	Transposase
MML47_01305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MML47_01320	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MML47_01375	COG0358	DNA primase activity
MML47_01380	COG1295	ribonuclease BN
MML47_01395	COG1610	YqeY-like protein
MML47_01405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MML47_01410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MML47_01425	COG2133	pyrroloquinoline quinone binding
MML47_01430	COG4682	membrane
MML47_01450	COG0531	amino acid
MML47_01465	COG4948	Mandelate Racemase Muconate Lactonizing
MML47_01475	COG3023	N-Acetylmuramoyl-L-alanine amidase
MML47_01485	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
MML47_01515	COG2826	transposase and inactivated derivatives, IS30 family
MML47_01550	COG1473	amidohydrolase
MML47_01555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MML47_01560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MML47_01580	COG5383	Protein conserved in bacteria
MML47_01595	COG2826	transposase and inactivated derivatives, IS30 family
MML47_01600	COG1028	Short-chain dehydrogenase reductase Sdr
MML47_01620	COG0513	Belongs to the DEAD box helicase family
MML47_01625	COG3039	Transposase
MML47_01650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MML47_01660	COG3483	tryptophan 2,3-dioxygenase activity
MML47_01670	COG3104	oligopeptide transport
MML47_01690	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MML47_01700	COG1320	monovalent cation:proton antiporter activity
MML47_01705	COG2212	antiporter activity
MML47_01715	COG0651	ATP synthesis coupled electron transport
MML47_01720	COG1006	Multisubunit Na H antiporter MnhC subunit
MML47_01725	COG2111	Na H antiporter
MML47_01725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MML47_01760	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MML47_01770	COG0456	acetyltransferase
MML47_01805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MML47_01810	COG0134	indole-3-glycerol-phosphate synthase activity
MML47_01820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MML47_01825	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MML47_01835	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
MML47_01845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MML47_01880	COG0745	RESPONSE REGULATOR receiver
MML47_01915	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MML47_01920	COG3039	Transposase
MML47_01925	COG3039	Transposase
MML47_01945	COG2814	Major facilitator Superfamily
MML47_01955	COG2814	Major facilitator Superfamily
MML47_01960	COG1289	transmembrane transporter activity
MML47_01970	COG0151	Belongs to the GarS family
MML47_01980	COG0138	bifunctional purine biosynthesis protein purh
MML47_02015	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MML47_02055	COG0439	Biotin carboxylase
MML47_02065	COG0511	ligase activity, forming carbon-carbon bonds
MML47_02070	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MML47_02085	COG1324	tolerance protein
MML47_02090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MML47_02110	COG0534	Mate efflux family protein
MML47_02115	COG0616	signal peptide processing
MML47_02125	COG1028	Short-chain dehydrogenase reductase Sdr
MML47_02140	COG0009	L-threonylcarbamoyladenylate synthase
MML47_02145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MML47_02145	COG1754	DNA topoisomerase type I activity
MML47_02165	COG0758	DNA mediated transformation
MML47_02170	COG1652	LysM domain
MML47_02175	COG0242	peptide deformylase activity
MML47_02180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MML47_02185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MML47_02185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MML47_02235	COG1560	Kdo2-lipid A biosynthetic process
MML47_02245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MML47_02280	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MML47_02280	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MML47_02315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MML47_02320	COG3118	belongs to the thioredoxin family
MML47_02330	COG2884	Cell division ATP-binding protein ftsE
MML47_02335	COG2177	Part of the ABC transporter FtsEX involved in
MML47_02340	COG2201	protein-glutamate methylesterase activity
MML47_02345	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MML47_02350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MML47_02355	COG2860	membrane
MML47_02360	COG1252	NADH dehydrogenase
MML47_02380	COG0459	protein refolding
MML47_02395	COG3550	peptidyl-serine autophosphorylation
MML47_02400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MML47_02415	COG3386	PFAM SMP-30 Gluconolaconase
MML47_02430	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MML47_02460	COG2353	YceI-like domain
MML47_02500	COG3039	Transposase
MML47_02505	COG0514	ATP-dependent DNA helicase (RecQ)
MML47_02530	COG4221	oxidoreductase activity
MML47_02575	COG0697	spore germination
MML47_02580	COG4305	rare lipoprotein A
MML47_02585	COG5297	Belongs to the glycosyl hydrolase family 6
MML47_02595	COG1113	amino acid transport
MML47_02605	COG0598	Magnesium transport protein CorA
MML47_02665	COG0840	transmembrane signaling receptor activity
MML47_02670	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MML47_02670	COG5297	Belongs to the glycosyl hydrolase family 6
MML47_02675	COG0659	secondary active sulfate transmembrane transporter activity
MML47_02705	COG3275	phosphorelay sensor kinase activity
MML47_02715	COG0181	hydroxymethylbilane synthase activity
MML47_02740	COG1505	serine-type exopeptidase activity
MML47_02745	COG0436	Aminotransferase
MML47_02755	COG2832	Protein of unknown function (DUF454)
MML47_02775	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MML47_02785	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MML47_02820	COG5001	Diguanylate cyclase
MML47_02820	COG3300	MHYT domain
MML47_02825	COG0308	aminopeptidase N
MML47_02840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MML47_02845	COG1077	Cell shape determining protein MreB Mrl
MML47_02850	COG1792	Involved in formation and maintenance of cell shape
MML47_02865	COG0772	Belongs to the SEDS family
MML47_02895	COG2951	lytic endotransglycosylase activity
MML47_02900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MML47_02905	COG1686	Belongs to the peptidase S11 family
MML47_02920	COG2921	Belongs to the UPF0250 family
MML47_02945	COG1051	belongs to the nudix hydrolase family
MML47_02945	COG1056	cytidyltransferase-related domain
MML47_02980	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MML47_02985	COG0673	inositol 2-dehydrogenase activity
MML47_02990	COG2823	Periplasmic or secreted lipoprotein
MML47_02995	COG4251	negative regulation of phosphorylation
MML47_03000	COG0784	Response regulator, receiver
MML47_03005	COG4191	Histidine kinase
MML47_03010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MML47_03045	COG3250	beta-galactosidase activity
MML47_03060	COG2188	Transcriptional regulator
MML47_03070	COG1609	Transcriptional regulator
MML47_03075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MML47_03080	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MML47_03090	COG1215	transferase activity, transferring glycosyl groups
MML47_03095	COG1649	PFAM Uncharacterised BCR, COG1649
MML47_03095	COG0726	polysaccharide deacetylase
MML47_03105	COG2826	transposase and inactivated derivatives, IS30 family
MML47_03130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MML47_03135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MML47_03160	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MML47_03200	COG2205	protein histidine kinase activity
MML47_03225	COG3791	Glutathione-dependent formaldehyde-activating
MML47_03250	COG0488	(ABC) transporter
MML47_03270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MML47_03280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MML47_03290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MML47_03290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MML47_03310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MML47_03315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MML47_03320	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MML47_03345	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MML47_03350	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MML47_03360	COG2205	protein histidine kinase activity
MML47_03365	COG0745	RESPONSE REGULATOR receiver
MML47_03370	COG0277	FAD linked oxidase domain protein
MML47_03375	COG1988	membrane-bound metal-dependent
MML47_03380	COG0792	nuclease activity
MML47_03420	COG0275	rRNA processing
MML47_03425	COG3116	cell division
MML47_03440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MML47_03445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MML47_03460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MML47_03465	COG1181	Belongs to the D-alanine--D-alanine ligase family
MML47_03470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MML47_03490	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MML47_03500	COG4942	peptidase
MML47_03500	COG1388	LysM domain
MML47_03515	COG0494	nUDIX hydrolase
MML47_03590	COG2226	methyltransferase
MML47_03595	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MML47_03635	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MML47_03650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MML47_03660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MML47_03665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MML47_03675	COG0667	Aldo Keto reductase
MML47_03715	COG2175	clavaminate synthase activity
MML47_03725	COG4181	ATPase activity
MML47_03740	COG0642	Histidine kinase
MML47_03755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MML47_03775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MML47_03795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MML47_03800	COG2967	ApaG domain
MML47_03805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MML47_03840	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MML47_03855	COG0123	including yeast histone deacetylase and acetoin utilization protein
MML47_03860	COG2096	Adenosyltransferase
MML47_03870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MML47_03875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MML47_03895	COG1802	Transcriptional regulator
MML47_03905	COG3384	dioxygenase
MML47_03910	COG0583	DNA-binding transcription factor activity
MML47_03925	COG1024	Enoyl-CoA hydratase
MML47_03945	COG3386	PFAM SMP-30 Gluconolaconase
MML47_03975	COG0697	spore germination
MML47_04010	COG2197	response regulator
MML47_04020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MML47_04025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MML47_04035	COG0583	DNA-binding transcription factor activity
MML47_04040	COG3634	alkyl hydroperoxide reductase activity
MML47_04050	COG2890	protein-(glutamine-N5) methyltransferase activity
MML47_04100	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MML47_04150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MML47_04160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MML47_04190	COG1295	ribonuclease BN
MML47_04195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MML47_04215	COG0521	Mo-molybdopterin cofactor biosynthetic process
MML47_04225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MML47_04230	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MML47_04240	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MML47_04255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MML47_04265	COG0193	aminoacyl-tRNA hydrolase activity
MML47_04270	COG0012	GTP binding
MML47_04300	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MML47_04305	COG0250	Participates in transcription elongation, termination and antitermination
MML47_04310	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MML47_04315	COG0081	regulation of translation
MML47_04320	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MML47_04325	COG0222	ribosome binding
MML47_04330	COG0085	RNA polymerase activity
MML47_04335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MML47_04340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MML47_04345	COG0049	tRNA binding
MML47_04365	COG0051	transcription antitermination factor activity, RNA binding
MML47_04375	COG0088	Forms part of the polypeptide exit tunnel
MML47_04380	COG0089	rRNA binding
MML47_04385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MML47_04395	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MML47_04405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MML47_04410	COG0255	Belongs to the universal ribosomal protein uL29 family
MML47_04415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MML47_04420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MML47_04425	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MML47_04450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MML47_04460	COG1841	ribosomal large subunit assembly
MML47_04465	COG0200	Binds to the 23S rRNA
MML47_04470	COG0201	protein transport
MML47_04485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MML47_04495	COG0203	ribosomal protein L17
MML47_04575	COG1560	Kdo2-lipid A biosynthetic process
MML47_04580	COG1519	Transferase
MML47_04585	COG1538	Outer membrane efflux protein
MML47_04590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MML47_04610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MML47_04615	COG0066	3-isopropylmalate dehydratase activity
MML47_04620	COG2226	methyltransferase
MML47_04650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MML47_04660	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MML47_04665	COG3710	Transcriptional regulator
MML47_04690	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MML47_04700	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MML47_04745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MML47_04755	COG3781	membrane
MML47_04765	COG0671	phosphoesterase, PA-phosphatase related
MML47_04775	COG1028	Short-chain dehydrogenase reductase Sdr
MML47_04785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MML47_04790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MML47_04840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MML47_04850	COG0352	thiamine-phosphate diphosphorylase activity
MML47_04855	COG1773	rubredoxin
MML47_04860	COG2912	Transglutaminase-like superfamily
MML47_04880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MML47_04905	COG0006	proline dipeptidase activity
MML47_04935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MML47_04945	COG0346	lactoylglutathione lyase activity
MML47_04950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MML47_04955	COG1561	YicC-like family, N-terminal region
MML47_04975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MML47_04985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MML47_05015	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MML47_05050	COG0714	Associated with various cellular activities
MML47_05070	COG2304	oxidoreductase activity
MML47_05090	COG1301	dicarboxylic acid transport
MML47_05095	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MML47_05105	COG0739	heme binding
MML47_05110	COG1376	ErfK ybiS ycfS ynhG family protein
MML47_05140	COG1022	Amp-dependent synthetase and ligase
MML47_05150	COG1028	Short-chain dehydrogenase reductase Sdr
MML47_05165	COG0642	Histidine kinase
MML47_05185	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MML47_05190	COG4149	molybdate abc transporter
MML47_05195	COG0725	ABC transporter, periplasmic molybdate-binding protein
MML47_05200	COG3453	Protein conserved in bacteria
MML47_05200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MML47_05210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MML47_05235	COG0469	pyruvate kinase activity
MML47_05240	COG3588	fructose-bisphosphate aldolase
MML47_05245	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MML47_05290	COG0784	Response regulator, receiver
MML47_05290	COG2198	Histidine kinase
MML47_05290	COG2205	protein histidine kinase activity
MML47_05310	COG0175	sulfate reduction
MML47_05315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MML47_05320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MML47_05325	COG0175	sulfate reduction
MML47_05330	COG2895	sulfate adenylyltransferase (ATP) activity
MML47_05330	COG0529	Catalyzes the synthesis of activated sulfate
MML47_05340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MML47_05345	COG0308	aminopeptidase N
MML47_05360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MML47_05375	COG1970	mechanosensitive ion channel activity
MML47_05400	COG0471	metal ion transport
MML47_05400	COG3273	potassium ion transport
MML47_05410	COG2022	thiamine diphosphate biosynthetic process
MML47_05525	COG3039	Transposase
MML47_05570	COG0745	RESPONSE REGULATOR receiver
MML47_05575	COG3039	Transposase
MML47_05590	COG2205	protein histidine kinase activity
MML47_05595	COG0237	dephospho-CoA kinase activity
MML47_05600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MML47_05615	COG2194	sulfuric ester hydrolase activity
MML47_05650	COG0045	succinate-CoA ligase (ADP-forming) activity
MML47_05655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MML47_05670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MML47_05670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MML47_05675	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MML47_05680	COG0564	pseudouridine synthase activity
MML47_05695	COG3011	Protein conserved in bacteria
MML47_05700	COG0840	transmembrane signaling receptor activity
MML47_05715	COG3387	PFAM Glycoside hydrolase 15-related
MML47_05720	COG1877	trehalose-phosphatase activity
MML47_05760	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MML47_05775	COG1595	DNA-templated transcription, initiation
MML47_05785	COG1946	Acyl-CoA thioesterase
MML47_05800	COG0824	Thioesterase
MML47_05805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MML47_05815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MML47_05820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MML47_05825	COG0268	Binds directly to 16S ribosomal RNA
MML47_05830	COG0728	peptidoglycan biosynthetic process
MML47_05835	COG0196	riboflavin kinase activity
MML47_05845	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MML47_05850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MML47_05865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MML47_05870	COG1845	cytochrome c oxidase, subunit III
MML47_05875	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MML47_05895	COG3209	COG3209 Rhs family protein
MML47_05905	COG3209	COG3209 Rhs family protein
MML47_05925	COG2826	transposase and inactivated derivatives, IS30 family
MML47_05955	COG2207	Transcriptional regulator
MML47_05960	COG0326	Molecular chaperone. Has ATPase activity
MML47_05970	COG1366	Belongs to the anti-sigma-factor antagonist family
MML47_05975	COG1366	Belongs to the anti-sigma-factor antagonist family
MML47_05980	COG2172	sigma factor antagonist activity
MML47_06020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MML47_06025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MML47_06060	COG3179	chitinase
MML47_06085	COG3179	chitinase
MML47_06265	COG2826	transposase and inactivated derivatives, IS30 family
MML47_06320	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MML47_06340	COG1842	Phage shock protein A
MML47_06365	COG0754	glutathionylspermidine amidase activity
MML47_06415	COG3039	Transposase
MML47_06430	COG0531	amino acid
MML47_06435	COG2197	response regulator
MML47_06440	COG2267	carboxylic ester hydrolase activity
MML47_06450	COG1113	amino acid transport
MML47_06460	COG1271	oxidase subunit
MML47_06465	COG1294	oxidase, subunit
MML47_06475	COG2239	Acts as a magnesium transporter
MML47_06480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MML47_06485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MML47_06495	COG1660	Displays ATPase and GTPase activities
MML47_06505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MML47_06520	COG1137	ATPase activity
MML47_06525	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MML47_06535	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MML47_06545	COG0271	Belongs to the BolA IbaG family
MML47_06550	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MML47_06570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MML47_06585	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MML47_06595	COG0628	permease
MML47_06605	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MML47_06610	COG3178	'Phosphotransferase
MML47_06620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MML47_06625	COG1555	photosystem II stabilization
MML47_06640	COG2146	nitrite reductase [NAD(P)H] activity
MML47_06650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MML47_06655	COG0719	Fe-S assembly protein
MML47_06660	COG0396	ATPase activity
MML47_06665	COG0719	Fe-S assembly protein
MML47_06670	COG1959	2 iron, 2 sulfur cluster binding
MML47_06725	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MML47_06760	COG0519	Catalyzes the synthesis of GMP from XMP
MML47_06770	COG1678	Uncharacterized ACR, COG1678
MML47_06775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MML47_06795	COG1764	response to oxidative stress
MML47_06805	COG0384	phenazine biosynthesis protein PhzF
MML47_06815	COG0527	aspartate kinase activity
MML47_06840	COG0142	geranyltranstransferase activity
MML47_06845	COG0629	single-stranded DNA binding
MML47_06890	COG3706	GGDEF domain
MML47_06890	COG5001	Diguanylate cyclase
MML47_06890	COG4251	negative regulation of phosphorylation
MML47_06890	COG2203	Gaf domain
MML47_06900	COG2080	2 iron, 2 sulfur cluster binding
MML47_06905	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MML47_06910	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MML47_06915	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MML47_06960	COG2879	small protein
MML47_06965	COG1966	Carbon starvation protein
MML47_06970	COG1741	Belongs to the pirin family
MML47_07015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MML47_07030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MML47_07040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MML47_07050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MML47_07255	COG2826	transposase and inactivated derivatives, IS30 family
MML47_07275	COG1741	Belongs to the pirin family
MML47_07285	COG1515	deoxyribonuclease V activity
MML47_07310	COG3409	Peptidoglycan-binding domain 1 protein
MML47_07310	COG3501	Rhs element vgr protein
MML47_07325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MML47_07330	COG2200	EAL domain
MML47_07330	COG2202	Pas domain
MML47_07330	COG2199	diguanylate cyclase activity
MML47_07335	COG0835	chemotaxis
MML47_07340	COG0840	transmembrane signaling receptor activity
MML47_07345	COG0643	Histidine kinase
MML47_07345	COG2198	Histidine kinase
MML47_07355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MML47_07365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MML47_07405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MML47_07410	COG0735	belongs to the Fur family
MML47_07500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MML47_07550	COG5001	Diguanylate cyclase
MML47_07550	COG5002	protein histidine kinase activity
MML47_07555	COG1187	pseudouridine synthase activity
MML47_07575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MML47_07585	COG0475	glutathione-regulated potassium exporter activity
MML47_07590	COG5000	phosphorelay sensor kinase activity
MML47_07590	COG5002	protein histidine kinase activity
MML47_07595	COG0745	RESPONSE REGULATOR receiver
MML47_07625	COG1132	(ABC) transporter
MML47_07685	COG3118	belongs to the thioredoxin family
MML47_07710	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MML47_07735	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MML47_07760	COG2968	Membrane
MML47_07775	COG3164	Protein of unknown function
MML47_07785	COG0312	modulator of DNA gyrase
MML47_07795	COG0312	modulator of DNA gyrase
MML47_07810	COG4104	PAAR repeat-containing protein
MML47_07815	COG0142	geranyltranstransferase activity
MML47_07820	COG1722	exodeoxyribonuclease VII activity
MML47_07825	COG0037	tRNA processing
MML47_07830	COG1785	Belongs to the alkaline phosphatase family
MML47_07835	COG1301	dicarboxylic acid transport
MML47_07840	COG4106	trans-aconitate 2-methyltransferase activity
MML47_07850	COG0791	NLP P60 protein
MML47_07855	COG0791	NLP P60 protein
MML47_07860	COG1047	Peptidyl-prolyl cis-trans
MML47_07865	COG2311	Membrane
MML47_07870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MML47_07955	COG3039	Transposase
MML47_07960	COG0489	protein tyrosine kinase activity
MML47_07965	COG0717	Belongs to the dCTP deaminase family
MML47_07990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MML47_07995	COG3039	Transposase
MML47_08015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MML47_08025	COG0840	transmembrane signaling receptor activity
MML47_08060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MML47_08065	COG0084	hydrolase, TatD family'
MML47_08080	COG1960	acyl-CoA dehydrogenase activity
MML47_08095	COG0367	asparagine synthase
MML47_08105	COG0305	Participates in initiation and elongation during chromosome replication
MML47_08110	COG0415	Belongs to the DNA photolyase family
MML47_08145	COG3706	GGDEF domain
MML47_08165	COG0174	glutamine synthetase
MML47_08170	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MML47_08175	COG1280	lysine exporter protein (LysE YggA)
MML47_08180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MML47_08195	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MML47_08225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MML47_08235	COG2914	Belongs to the UPF0125 (RnfH) family
MML47_08245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MML47_08255	COG0497	DNA recombination
MML47_08265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MML47_08270	COG0443	Heat shock 70 kDa protein
MML47_08275	COG0484	heat shock protein binding
MML47_08280	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MML47_08310	COG0583	DNA-binding transcription factor activity
MML47_08320	COG1132	(ABC) transporter
MML47_08355	COG2850	peptidyl-arginine hydroxylation
MML47_08415	COG1131	(ABC) transporter
MML47_08420	COG1725	Transcriptional regulator
MML47_08430	COG0386	Belongs to the glutathione peroxidase family
MML47_08445	COG2900	Belongs to the SlyX family
MML47_08470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MML47_08480	COG1410	methionine synthase
MML47_08480	COG0646	methionine synthase
MML47_08485	COG0646	methionine synthase
MML47_08485	COG1410	methionine synthase
MML47_08490	COG2226	methyltransferase
MML47_08495	COG1960	acyl-CoA dehydrogenase activity
MML47_08515	COG0557	exoribonuclease II activity
MML47_08530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MML47_08540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MML47_08550	COG0704	Plays a role in the regulation of phosphate uptake
MML47_08565	COG0573	inorganic phosphate transmembrane transporter activity
MML47_08570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MML47_08595	COG0659	secondary active sulfate transmembrane transporter activity
MML47_08600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MML47_08610	COG1024	Enoyl-CoA hydratase
MML47_08625	COG0494	nUDIX hydrolase
MML47_08670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MML47_08670	COG0116	Belongs to the methyltransferase superfamily
MML47_08695	COG0667	Aldo Keto reductase
MML47_08705	COG2925	Exonuclease
MML47_08715	COG3844	kynureninase activity
MML47_08730	COG0288	reversible hydration of carbon dioxide
MML47_08760	COG0316	Belongs to the HesB IscA family
MML47_08765	COG0360	Binds together with S18 to 16S ribosomal RNA
MML47_08785	COG3115	cell septum assembly
MML47_08800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MML47_08805	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MML47_08820	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MML47_08880	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MML47_08890	COG2986	histidine ammonia-lyase
MML47_08895	COG1228	amidohydrolase
MML47_08935	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MML47_08940	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MML47_08945	COG0077	Prephenate dehydratase
MML47_08945	COG1605	Chorismate mutase
MML47_08950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MML47_08970	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MML47_08985	COG0583	DNA-binding transcription factor activity
MML47_09045	COG0840	transmembrane signaling receptor activity
MML47_09060	COG5002	protein histidine kinase activity
MML47_09060	COG0784	Response regulator, receiver
MML47_09060	COG2205	protein histidine kinase activity
MML47_09065	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MML47_09070	COG4191	Histidine kinase
MML47_09070	COG0784	Response regulator, receiver
MML47_09085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MML47_09105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MML47_09120	COG1595	DNA-templated transcription, initiation
MML47_09170	COG2244	polysaccharide biosynthetic process
MML47_09200	COG2264	protein methyltransferase activity
MML47_09210	COG0438	transferase activity, transferring glycosyl groups
MML47_09225	COG1136	(ABC) transporter
MML47_09230	COG1132	(ABC) transporter
MML47_09240	COG2271	Major facilitator Superfamily
MML47_09250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MML47_09265	COG1253	flavin adenine dinucleotide binding
MML47_09300	COG0504	CTP synthase activity
MML47_09305	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MML47_09315	COG0148	phosphopyruvate hydratase activity
MML47_09320	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MML47_09335	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MML47_09345	COG2840	Smr protein MutS2
MML47_09350	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MML47_09355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MML47_09360	COG1238	metal cluster binding
MML47_09375	COG1534	Rna-binding protein
MML47_09380	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MML47_09390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MML47_09405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MML47_09410	COG1546	Belongs to the CinA family
MML47_09425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MML47_09430	COG2137	regulation of response to DNA damage stimulus
MML47_09435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MML47_09440	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MML47_09450	COG0305	Participates in initiation and elongation during chromosome replication
MML47_09465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MML47_09490	COG1741	Belongs to the pirin family
MML47_09495	COG0583	DNA-binding transcription factor activity
MML47_09520	COG0351	phosphomethylpyrimidine kinase
MML47_09520	COG0352	thiamine-phosphate diphosphorylase activity
MML47_09530	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MML47_09535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MML47_09550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MML47_09560	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MML47_09565	COG3734	2-keto-3-deoxy-galactonokinase
MML47_09575	COG4948	Mandelate Racemase Muconate Lactonizing
MML47_09580	COG0800	Aldolase
MML47_09605	COG1070	Carbohydrate kinase
MML47_09615	COG0477	Major facilitator Superfamily
MML47_09635	COG3039	Transposase
MML47_09640	COG0860	N-Acetylmuramoyl-L-alanine amidase
MML47_09645	COG1469	GTP cyclohydrolase I activity
MML47_09655	COG0617	tRNA 3'-terminal CCA addition
MML47_09675	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MML47_09700	COG1472	Belongs to the glycosyl hydrolase 3 family
MML47_09715	COG4251	negative regulation of phosphorylation
MML47_09715	COG5001	Diguanylate cyclase
MML47_09715	COG3706	GGDEF domain
MML47_09715	COG2203	Gaf domain
MML47_09725	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MML47_09730	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MML47_09745	COG0671	phosphoesterase, PA-phosphatase related
MML47_09770	COG0697	spore germination
MML47_09775	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MML47_09795	COG1012	belongs to the aldehyde dehydrogenase family
MML47_09855	COG0515	serine threonine protein kinase
MML47_09855	COG2815	serine threonine protein kinase
MML47_09950	COG3039	Transposase
MML47_09955	COG2814	Major facilitator Superfamily
MML47_09970	COG3039	Transposase
MML47_09980	COG3039	Transposase
MML47_09990	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MML47_09990	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MML47_10030	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MML47_10040	COG0124	histidyl-tRNA synthetase
MML47_10055	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MML47_10070	COG0131	Imidazoleglycerol-phosphate dehydratase
MML47_10070	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MML47_10080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MML47_10090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MML47_10090	COG0140	phosphoribosyl-ATP diphosphatase activity
MML47_10110	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MML47_10115	COG0235	Class ii aldolase
MML47_10120	COG0531	amino acid
MML47_10125	COG0531	amino acid
MML47_10135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MML47_10140	COG0277	FAD linked oxidase domain protein
MML47_10160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MML47_10205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MML47_10210	COG2258	MOSC domain
MML47_10215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MML47_10220	COG0505	Belongs to the CarA family
MML47_10230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MML47_10235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MML47_10245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MML47_10260	COG3279	Response regulator of the LytR AlgR family
MML47_10280	COG0784	Response regulator, receiver
MML47_10280	COG2198	Histidine kinase
MML47_10280	COG2205	protein histidine kinase activity
MML47_10285	COG1024	Enoyl-CoA hydratase
MML47_10290	COG0318	PFAM AMP-dependent synthetase and ligase
MML47_10320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MML47_10350	COG0840	transmembrane signaling receptor activity
MML47_10360	COG0835	chemotaxis
MML47_10375	COG0840	transmembrane signaling receptor activity
MML47_10380	COG0840	transmembrane signaling receptor activity
MML47_10385	COG0840	transmembrane signaling receptor activity
MML47_10390	COG0840	transmembrane signaling receptor activity
MML47_10395	COG0840	transmembrane signaling receptor activity
MML47_10405	COG0840	transmembrane signaling receptor activity
MML47_10415	COG0840	transmembrane signaling receptor activity
MML47_10420	COG0840	transmembrane signaling receptor activity
MML47_10425	COG0840	transmembrane signaling receptor activity
MML47_10435	COG0840	transmembrane signaling receptor activity
MML47_10460	COG0840	transmembrane signaling receptor activity
MML47_10470	COG0745	RESPONSE REGULATOR receiver
MML47_10480	COG0835	chemotaxis
MML47_10485	COG1192	Involved in chromosome partitioning
MML47_10490	COG1360	Flagellar Motor Protein
MML47_10495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MML47_10505	COG4774	siderophore transport
MML47_10510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MML47_10605	COG0800	Aldolase
MML47_10610	COG0129	dihydroxy-acid dehydratase activity
MML47_10615	COG0363	glucosamine-6-phosphate deaminase activity
MML47_10625	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MML47_10640	COG0354	folic acid binding
MML47_10655	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MML47_10670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MML47_10685	COG4591	ABC-type transport system involved in lipoprotein release permease component
MML47_10705	COG0811	peptide transport
MML47_10720	COG1663	tetraacyldisaccharide 4'-kinase activity
MML47_10730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MML47_10740	COG0322	excinuclease ABC activity
MML47_10775	COG0037	tRNA processing
MML47_10795	COG2234	aminopeptidase activity
MML47_10810	COG3501	Rhs element vgr protein
MML47_10810	COG3409	Peptidoglycan-binding domain 1 protein
MML47_10840	COG3039	Transposase
MML47_10865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MML47_10885	COG1054	Belongs to the UPF0176 family
MML47_10895	COG1530	ribonuclease E activity
MML47_10905	COG3064	Membrane
MML47_10920	COG2154	pterin-4-alpha-carbinolamine dehydratase
MML47_10935	COG2801	Transposase and inactivated derivatives
MML47_11145	COG0631	protein serine/threonine phosphatase activity
MML47_11150	COG0515	serine threonine protein kinase
MML47_11180	COG1858	cytochrome C peroxidase
MML47_11230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MML47_11235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MML47_11535	COG4566	intracellular signal transduction
MML47_11545	COG5001	Diguanylate cyclase
MML47_11565	COG3685	Protein conserved in bacteria
MML47_11595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MML47_11595	COG1648	precorrin-2 dehydrogenase activity
MML47_11620	COG0746	molybdenum cofactor guanylyltransferase activity
MML47_11655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MML47_11665	COG0303	'Molybdopterin
MML47_11670	COG1160	GTP binding
MML47_11675	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MML47_11695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MML47_11710	COG1250	3-hydroxyacyl-CoA dehydrogenase
MML47_11710	COG1024	Enoyl-CoA hydratase
MML47_11715	COG0183	Belongs to the thiolase family
MML47_11720	COG0038	chloride channel
MML47_11740	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MML47_11760	COG1674	ftsk spoiiie
MML47_11765	COG0492	ferredoxin-NADP+ reductase activity
MML47_11790	COG0542	response to heat
MML47_11805	COG0482	sulfurtransferase activity
MML47_11835	COG4585	Histidine kinase
MML47_11845	COG5002	protein histidine kinase activity
MML47_11865	COG0784	Response regulator, receiver
MML47_11865	COG0835	chemotaxis
MML47_11875	COG1558	bacterial-type flagellum-dependent cell motility
MML47_11880	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MML47_11890	COG4787	bacterial-type flagellum-dependent cell motility
MML47_11900	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MML47_11905	COG1706	bacterial-type flagellum-dependent cell motility
MML47_11925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MML47_11930	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MML47_11960	COG2201	protein-glutamate methylesterase activity
MML47_11980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MML47_11990	COG1028	Short-chain dehydrogenase reductase Sdr
MML47_12045	COG1677	Flagellar hook-basal body complex protein FliE
MML47_12095	COG3190	flagellar
MML47_12110	COG1684	flagellar biosynthetic protein fliR
MML47_12165	COG0643	Histidine kinase
MML47_12165	COG0784	Response regulator, receiver
MML47_12165	COG2198	Histidine kinase
MML47_12255	COG2205	protein histidine kinase activity
MML47_12255	COG0784	Response regulator, receiver
MML47_12265	COG2183	response to ionizing radiation
MML47_12275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MML47_12275	COG0723	plastoquinol--plastocyanin reductase activity
MML47_12290	COG3243	poly(R)-hydroxyalkanoic acid synthase
MML47_12300	COG1183	phosphatidylcholine synthase activity
MML47_12305	COG1028	Short-chain dehydrogenase reductase Sdr
MML47_12320	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MML47_12330	COG0668	transmembrane transport
MML47_12350	COG1914	H( )-stimulated, divalent metal cation uptake system
MML47_12370	COG0583	DNA-binding transcription factor activity
MML47_12385	COG1028	Short-chain dehydrogenase reductase Sdr
MML47_12400	COG0583	DNA-binding transcription factor activity
MML47_12405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MML47_12410	COG3002	Belongs to the UPF0753 family
MML47_12415	COG0519	Catalyzes the synthesis of GMP from XMP
MML47_12415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MML47_12425	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MML47_12440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MML47_12450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MML47_12455	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MML47_12465	COG0776	regulation of translation
MML47_12470	COG0539	negative regulation of cytoplasmic translation
MML47_12475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MML47_12490	COG2957	Belongs to the agmatine deiminase family
MML47_12500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MML47_12525	COG0395	ABC-type sugar transport system, permease component
MML47_12530	COG1175	transmembrane transport
MML47_12560	COG2350	Protein conserved in bacteria
MML47_12565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MML47_12570	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MML47_12575	COG1187	pseudouridine synthase activity
MML47_12595	COG0436	Aminotransferase
MML47_12600	COG4133	protoheme IX ABC transporter activity
MML47_12650	COG1278	Cold shock
MML47_12660	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MML47_12665	COG4988	ABC transporter
MML47_12720	COG0165	Argininosuccinate lyase
MML47_12735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MML47_12740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MML47_12745	COG0137	argininosuccinate synthase activity
MML47_12750	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MML47_12765	COG2166	iron-sulfur cluster assembly
MML47_12795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MML47_12820	COG4677	pectinesterase activity
MML47_12845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MML47_12850	COG0402	S-adenosylhomocysteine deaminase activity
MML47_12865	COG1509	lysine 2,3-aminomutase activity
MML47_12870	COG3300	MHYT domain
MML47_12870	COG5001	Diguanylate cyclase
MML47_12885	COG0483	inositol monophosphate 1-phosphatase activity
MML47_12890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MML47_12910	COG0488	(ABC) transporter
MML47_12915	COG0513	Belongs to the DEAD box helicase family
MML47_12925	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MML47_12935	COG0625	glutathione transferase activity
MML47_12945	COG1671	Belongs to the UPF0178 family
MML47_12950	COG4681	YaeQ
MML47_12955	COG2081	HI0933 family
MML47_12965	COG0501	Belongs to the peptidase M48B family
MML47_12975	COG1028	Short-chain dehydrogenase reductase Sdr
MML47_12995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MML47_13000	COG0860	N-Acetylmuramoyl-L-alanine amidase
MML47_13005	COG0802	atpase or kinase
MML47_13010	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MML47_13010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MML47_13015	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MML47_13035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MML47_13070	COG0582	viral genome integration into host DNA
MML47_13130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MML47_13225	COG2801	Transposase and inactivated derivatives
MML47_13240	COG0835	chemotaxis
MML47_13245	COG0840	transmembrane signaling receptor activity
MML47_13270	COG2969	positive regulation of protein catabolic process
MML47_13275	COG0625	glutathione transferase activity
MML47_13280	COG2857	Cytochrome c1
MML47_13285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MML47_13290	COG0723	plastoquinol--plastocyanin reductase activity
MML47_13295	COG0741	lytic transglycosylase activity
MML47_13315	COG1702	phosphate starvation-inducible protein PhoH
MML47_13335	COG4535	Mg2 and Co2 transporter CorC
MML47_13350	COG1012	belongs to the aldehyde dehydrogenase family
MML47_13360	COG1177	transmembrane transport
MML47_13365	COG1176	ABC-type spermidine putrescine transport system, permease component I
MML47_13375	COG3842	ATPase activity
MML47_13395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MML47_13425	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MML47_13430	COG0174	glutamine synthetase
MML47_13435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MML47_13445	COG0477	Major facilitator Superfamily
MML47_13455	COG0243	molybdopterin cofactor binding
MML47_13465	COG2223	nitrite transmembrane transporter activity
MML47_13470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MML47_13475	COG1121	(ABC) transporter
MML47_13485	COG2733	membrane
MML47_13520	COG0477	Major facilitator Superfamily
MML47_13540	COG2902	Dehydrogenase
MML47_13550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MML47_13555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MML47_13565	COG1609	Transcriptional regulator
MML47_13570	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MML47_13570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MML47_13575	COG1105	Belongs to the carbohydrate kinase PfkB family
MML47_13580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MML47_13580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MML47_13635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MML47_13645	COG1862	Preprotein translocase
MML47_13650	COG0343	queuine tRNA-ribosyltransferase activity
MML47_13700	COG0405	Gamma-glutamyltransferase
MML47_13705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MML47_13715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MML47_13720	COG0742	ribosomal rna small subunit methyltransferase
MML47_13725	COG0326	Molecular chaperone. Has ATPase activity
MML47_13780	COG4206	TonB-dependent receptor
MML47_13810	COG0531	amino acid
MML47_13825	COG0006	proline dipeptidase activity
MML47_13835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MML47_13850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MML47_13855	COG3938	Belongs to the proline racemase family
MML47_13865	COG0552	protein localization to endoplasmic reticulum
MML47_13875	COG1194	a g-specific adenine glycosylase
MML47_13885	COG0784	Response regulator, receiver
MML47_13885	COG4191	Histidine kinase
MML47_13890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MML47_13910	COG3040	lipid binding
MML47_13920	COG1960	acyl-CoA dehydrogenase activity
MML47_13930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MML47_13960	COG0438	transferase activity, transferring glycosyl groups
MML47_13970	COG0438	transferase activity, transferring glycosyl groups
MML47_13975	COG0438	transferase activity, transferring glycosyl groups
MML47_14030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MML47_14045	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MML47_14080	COG0556	nucleotide-excision repair
MML47_14085	COG4969	Belongs to the N-Me-Phe pilin family
MML47_14145	COG4695	Portal protein
MML47_14190	COG3179	chitinase
MML47_14385	COG2826	transposase and inactivated derivatives, IS30 family
MML47_14415	COG1611	Belongs to the LOG family
MML47_14430	COG2095	MarC family integral membrane protein
MML47_14440	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MML47_14475	COG1185	polyribonucleotide nucleotidyltransferase activity
MML47_14480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MML47_14495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MML47_14500	COG0195	Participates in both transcription termination and antitermination
MML47_14505	COG0779	Required for maturation of 30S ribosomal subunits
MML47_14515	COG1007	ATP synthesis coupled electron transport
MML47_14545	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MML47_14550	COG1034	ATP synthesis coupled electron transport
MML47_14555	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MML47_14560	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MML47_14565	COG0649	NAD binding
MML47_14570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MML47_14580	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MML47_14595	COG0149	triose-phosphate isomerase activity
MML47_14635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MML47_14640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MML47_14655	COG0133	tryptophan synthase activity
MML47_14665	COG0135	phosphoribosylanthranilate isomerase activity
MML47_14670	COG0101	tRNA pseudouridine synthase activity
MML47_14690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MML47_14695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MML47_14700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MML47_14705	COG2890	protein-(glutamine-N5) methyltransferase activity
MML47_14730	COG0433	COG0433 Predicted ATPase
MML47_14735	COG2826	transposase and inactivated derivatives, IS30 family
MML47_14750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MML47_14770	COG3039	Transposase
MML47_14775	COG2826	transposase and inactivated derivatives, IS30 family
MML47_14830	COG0386	Belongs to the glutathione peroxidase family
MML47_14835	COG0339	signal peptide processing
MML47_14905	COG3039	Transposase
MML47_14925	COG2814	Major facilitator Superfamily
MML47_14930	COG1566	PFAM secretion protein HlyD family protein
MML47_14945	COG2207	Transcriptional regulator
MML47_14965	COG4774	siderophore transport
MML47_14975	COG0367	asparagine synthase
MML47_14980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MML47_14990	COG1393	Belongs to the ArsC family
MML47_15050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MML47_15065	COG0233	cytoplasmic translational termination
MML47_15075	COG0575	Belongs to the CDS family
MML47_15080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MML47_15085	COG0750	zinc metalloprotease
MML47_15095	COG2826	transposase and inactivated derivatives, IS30 family
MML47_15100	COG3039	Transposase
MML47_15105	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MML47_15110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MML47_15115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MML47_15135	COG0825	malonyl-CoA metabolic process
MML47_15160	COG1981	membrane
MML47_15205	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MML47_15220	COG2040	homocysteine
MML47_15225	COG0833	amino acid
MML47_15230	COG0346	lactoylglutathione lyase activity
MML47_15240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MML47_15240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MML47_15250	COG2878	Part of a membrane complex involved in electron transport
MML47_15265	COG1595	DNA-templated transcription, initiation
MML47_15290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MML47_15305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MML47_15310	COG0251	oxidation-reduction process
MML47_15320	COG0392	lysyltransferase activity
MML47_15320	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MML47_15355	COG2814	Major facilitator Superfamily
MML47_15360	COG1902	pentaerythritol trinitrate reductase activity
MML47_15370	COG2824	Alkylphosphonate utilization operon protein PhnA
MML47_15380	COG1047	Peptidyl-prolyl cis-trans
MML47_15420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MML47_15435	COG1451	nucleotide metabolic process
MML47_15460	COG0183	Belongs to the thiolase family
MML47_15490	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MML47_15490	COG1793	dna ligase
MML47_15500	COG1793	dna ligase
MML47_15505	COG1201	RNA secondary structure unwinding
MML47_15520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MML47_15525	COG1278	Cold shock
MML47_15530	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MML47_15535	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MML47_15545	COG3046	protein related to deoxyribodipyrimidine photolyase
MML47_15550	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
MML47_15555	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MML47_15560	COG2954	triphosphatase activity
MML47_15575	COG1381	Involved in DNA repair and RecF pathway recombination
MML47_15600	COG0481	GTPase activity
MML47_15605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MML47_15620	COG1024	Enoyl-CoA hydratase
MML47_15620	COG1250	3-hydroxyacyl-CoA dehydrogenase
MML47_15640	COG1024	Enoyl-CoA hydratase
MML47_15645	COG1960	acyl-CoA dehydrogenase activity
MML47_15710	COG0784	Response regulator, receiver
MML47_15710	COG5002	protein histidine kinase activity
MML47_15715	COG0784	Response regulator, receiver
MML47_15715	COG2198	Histidine kinase
MML47_15715	COG2205	protein histidine kinase activity
MML47_15720	COG2353	YceI-like domain
MML47_15745	COG1760	l-serine dehydratase
MML47_15750	COG0527	aspartate kinase activity
MML47_15750	COG0460	homoserine dehydrogenase
MML47_15755	COG0626	cystathionine gamma-synthase activity
MML47_15760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MML47_15765	COG0739	heme binding
MML47_15775	COG1272	protein, Hemolysin III
MML47_15780	COG2982	Protein involved in outer membrane biogenesis
MML47_15785	COG0516	GMP reductase activity
MML47_15785	COG0517	IMP dehydrogenase activity
MML47_15790	COG0463	Glycosyl transferase, family 2
MML47_15800	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MML47_15810	COG4771	TonB-dependent receptor
MML47_15815	COG1309	transcriptional regulator
MML47_15825	COG1960	acyl-CoA dehydrogenase activity
MML47_15855	COG0509	glycine decarboxylation via glycine cleavage system
MML47_15870	COG0330	HflC and HflK could
MML47_15880	COG1742	UPF0060 membrane protein
MML47_15885	COG3956	TIGRFAM MazG family protein
MML47_15895	COG0494	nUDIX hydrolase
MML47_15905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MML47_15910	COG0837	glucose binding
MML47_15925	COG1388	LysM domain
MML47_15925	COG3858	chitin binding
MML47_15935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MML47_15945	COG1472	Belongs to the glycosyl hydrolase 3 family
MML47_15975	COG2826	transposase and inactivated derivatives, IS30 family
MML47_15995	COG3537	Alpha-1,2-mannosidase
MML47_16035	COG3142	Participates in the control of copper homeostasis
MML47_16040	COG1446	asparaginase
MML47_16045	COG2304	oxidoreductase activity
MML47_16065	COG2198	Histidine kinase
MML47_16065	COG0784	Response regulator, receiver
MML47_16065	COG0643	Histidine kinase
MML47_16070	COG0840	transmembrane signaling receptor activity
MML47_16075	COG0835	chemotaxis
MML47_16090	COG0189	ligase activity
MML47_16110	COG1199	ATP-dependent helicase activity
MML47_16120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MML47_16125	COG1215	transferase activity, transferring glycosyl groups
MML47_16135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MML47_16185	COG1643	Atp-dependent helicase
MML47_16190	COG0783	Belongs to the Dps family
MML47_16195	COG0514	ATP-dependent DNA helicase (RecQ)
MML47_16210	COG1187	pseudouridine synthase activity
MML47_16250	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MML47_16260	COG0602	queuosine metabolic process
MML47_16270	COG2885	chlorophyll binding
MML47_16275	COG0823	Involved in the tonB-independent uptake of proteins
MML47_16295	COG0824	Thioesterase
MML47_16300	COG2255	four-way junction helicase activity
MML47_16315	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MML47_16320	COG0217	transcriptional regulatory protein
MML47_16335	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MML47_16350	COG0477	Major facilitator Superfamily
MML47_16365	COG0657	acetylesterase activity
MML47_16365	COG2755	lipolytic protein G-D-S-L family
MML47_16385	COG0488	(ABC) transporter
MML47_16415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MML47_16415	COG4651	solute:proton antiporter activity
MML47_16430	COG4772	TonB-dependent receptor
MML47_16440	COG4264	IucA IucC family
MML47_16455	COG0019	diaminopimelate decarboxylase activity
MML47_16475	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MML47_16515	COG4206	TonB-dependent receptor
MML47_16555	COG0542	response to heat
MML47_16580	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MML47_16600	COG0534	Mate efflux family protein
MML47_16615	COG0336	Belongs to the RNA methyltransferase TrmD family
MML47_16620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MML47_16625	COG0228	four-way junction DNA binding
MML47_16800	COG2963	transposase activity
MML47_16805	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MML47_16830	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MML47_16845	COG2197	response regulator
MML47_16850	COG4585	Histidine kinase
MML47_16865	COG2894	cell division
MML47_16870	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MML47_16885	COG0642	Histidine kinase
MML47_16890	COG0745	RESPONSE REGULATOR receiver
MML47_16895	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MML47_16905	COG2194	sulfuric ester hydrolase activity
MML47_16935	COG3551	Protein conserved in bacteria
MML47_16945	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MML47_16945	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MML47_16975	COG0753	catalase activity
MML47_17010	COG2826	transposase and inactivated derivatives, IS30 family
MML47_17015	COG1917	Cupin 2, conserved barrel domain protein
MML47_17015	COG2207	Transcriptional regulator
MML47_17025	COG0823	Involved in the tonB-independent uptake of proteins
MML47_17025	COG1506	peptidase
MML47_17040	COG1297	OPT oligopeptide transporter protein
MML47_17055	COG0587	DNA-directed DNA polymerase activity
MML47_17135	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MML47_17150	COG0732	type I restriction modification DNA specificity domain
MML47_17200	COG0308	aminopeptidase N
MML47_17205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MML47_17215	COG0330	HflC and HflK could
MML47_17220	COG0330	HflC and HflK could
MML47_17300	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MML47_17315	COG3829	transcription factor binding
MML47_17345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MML47_17350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MML47_17360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MML47_17365	COG1028	Short-chain dehydrogenase reductase Sdr
MML47_17390	COG1399	metal-binding, possibly nucleic acid-binding protein
MML47_17410	COG0714	Associated with various cellular activities
MML47_17430	COG0537	adenosine 5'-monophosphoramidase activity
MML47_17440	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MML47_17555	COG0314	molybdopterin synthase activity
MML47_17560	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MML47_17565	COG0315	cyclic pyranopterin monophosphate synthase activity
MML47_17575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MML47_17580	COG1234	tRNA 3'-trailer cleavage
MML47_17585	COG3642	lipopolysaccharide core region biosynthetic process
MML47_17590	COG0859	PFAM glycosyl transferase family 9
MML47_17605	COG0631	protein serine/threonine phosphatase activity
MML47_17615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MML47_17640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MML47_17680	COG0544	peptidyl-prolyl cis-trans isomerase activity
MML47_17690	COG3852	Histidine kinase
MML47_17730	COG0473	3-isopropylmalate dehydrogenase activity
MML47_17745	COG4783	chaperone-mediated protein folding
MML47_17760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MML47_17775	COG0671	phosphoesterase, PA-phosphatase related
MML47_17780	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MML47_17800	COG2833	Protein of unknown function (DUF455)
MML47_17820	COG0285	dihydrofolate synthase activity
MML47_17835	COG0406	alpha-ribazole phosphatase activity
MML47_17865	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MML47_17870	COG4208	sulfate ABC transporter
MML47_17875	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MML47_17880	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MML47_17885	COG0156	8-amino-7-oxononanoate synthase activity
MML47_17915	COG0446	pyridine nucleotide-disulphide oxidoreductase
MML47_17915	COG1902	pentaerythritol trinitrate reductase activity
MML47_17935	COG0584	glycerophosphoryl diester phosphodiesterase
MML47_17945	COG0625	glutathione transferase activity
MML47_17955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MML47_17960	COG1217	gtp-binding protein TYPA
MML47_17980	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MML47_18005	COG0280	phosphate acetyltransferase
MML47_18005	COG0281	malic enzyme
MML47_18025	COG4191	Histidine kinase
MML47_18040	COG0583	DNA-binding transcription factor activity
MML47_18060	COG2826	transposase and inactivated derivatives, IS30 family
MML47_18070	COG2197	response regulator
MML47_18080	COG0642	Histidine kinase
MML47_18095	COG2851	Citrate transporter
MML47_18100	COG1028	Short-chain dehydrogenase reductase Sdr
MML47_18105	COG1609	Transcriptional regulator
MML47_18115	COG2211	Major facilitator Superfamily
MML47_18145	COG0436	Aminotransferase
MML47_18170	COG0726	polysaccharide deacetylase
MML47_18175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MML47_18200	COG3964	amidohydrolase
MML47_18205	COG0402	S-adenosylhomocysteine deaminase activity
MML47_18240	COG0242	peptide deformylase activity
MML47_18255	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MML47_18305	COG2188	Transcriptional regulator
MML47_18335	COG1450	Type ii and iii secretion system protein
MML47_18350	COG3166	PFAM Fimbrial assembly family protein
MML47_18355	COG3156	type II secretion system protein K
MML47_18360	COG4795	General secretion pathway protein
MML47_18365	COG2165	general secretion pathway protein
MML47_18370	COG4970	Tfp pilus assembly protein FimT
MML47_18375	COG2165	general secretion pathway protein
MML47_18380	COG1459	type II secretion system
MML47_18390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MML47_18395	COG1404	Belongs to the peptidase S8 family
MML47_18400	COG5295	Hep Hag repeat protein
MML47_18405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MML47_18405	COG0047	phosphoribosylformylglycinamidine synthase activity
MML47_18410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MML47_18415	COG4974	Belongs to the 'phage' integrase family
MML47_18430	COG0795	lipopolysaccharide-transporting ATPase activity
MML47_18440	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MML47_18455	COG0525	valine-tRNA ligase activity
MML47_18485	COG1183	phosphatidylcholine synthase activity
MML47_18495	COG0442	prolyl-tRNA aminoacylation
MML47_18510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MML47_18515	COG1127	ABC transporter
MML47_18520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MML47_18520	COG3218	ABC-type transport auxiliary lipoprotein component
MML47_18555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MML47_18560	COG0662	Cupin 2, conserved barrel domain protein
MML47_18560	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MML47_18585	COG2086	electron transfer activity
MML47_18610	COG3328	transposase activity
MML47_18650	COG0626	cystathionine gamma-synthase activity
MML47_18685	COG0625	glutathione transferase activity
MML47_18695	COG0513	Belongs to the DEAD box helicase family
MML47_18700	COG0720	synthase
MML47_18710	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MML47_18715	COG1956	GAF domain-containing protein
MML47_18725	COG0546	phosphoglycolate phosphatase activity
MML47_18750	COG0339	signal peptide processing
MML47_18795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MML47_18855	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MML47_18860	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MML47_18865	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MML47_18875	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MML47_18885	COG0356	it plays a direct role in the translocation of protons across the membrane
MML47_18905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MML47_18915	COG0508	dehydrogenase complex catalyzes the overall conversion of
MML47_18950	COG2011	ABC-type metal ion transport system permease component
MML47_18960	COG0697	spore germination
MML47_18995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MML47_19000	COG1187	pseudouridine synthase activity
MML47_19005	COG2813	Specifically methylates the guanine in position
MML47_19035	COG2202	Pas domain
MML47_19035	COG2205	protein histidine kinase activity
MML47_19060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MML47_19110	COG0745	RESPONSE REGULATOR receiver
MML47_19125	COG1404	Belongs to the peptidase S8 family
MML47_19140	COG0842	Transport permease protein
MML47_19145	COG1131	(ABC) transporter
MML47_19150	COG0025	NhaP-type Na H and K H
MML47_19160	COG3039	Transposase
MML47_19165	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MML47_19175	COG1573	uracil-dna glycosylase
MML47_19185	COG3384	dioxygenase
MML47_19200	COG0667	Aldo Keto reductase
MML47_19215	COG3590	peptidase
MML47_19235	COG0531	amino acid
MML47_19250	COG2972	Histidine kinase
MML47_19265	COG3685	Protein conserved in bacteria
MML47_19270	COG3546	catalase activity
MML47_19300	COG2204	response regulator
MML47_19310	COG1271	oxidase subunit
MML47_19315	COG1294	oxidase, subunit
MML47_19340	COG1063	alcohol dehydrogenase
MML47_19415	COG2826	transposase and inactivated derivatives, IS30 family
MML47_19425	COG0702	epimerase
MML47_19450	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MML47_19470	COG1649	PFAM Uncharacterised BCR, COG1649
MML47_19475	COG2354	Protein conserved in bacteria
MML47_19480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MML47_19495	COG3264	Mechanosensitive ion channel
MML47_19495	COG1511	domain protein
MML47_19570	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MML47_19660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MML47_19665	COG1040	competence protein
MML47_19670	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MML47_19675	COG0156	8-amino-7-oxononanoate synthase activity
MML47_19715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MML47_19735	COG3541	Predicted nucleotidyltransferase
MML47_19745	COG0657	acetylesterase activity
MML47_19755	COG1414	Transcriptional regulator
MML47_19770	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MML47_19775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MML47_19790	COG3485	protocatechuate 3,4-dioxygenase
MML47_19795	COG3485	protocatechuate 3,4-dioxygenase
MML47_19805	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MML47_19810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MML47_19885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MML47_19895	COG0129	dihydroxy-acid dehydratase activity
MML47_19920	COG2032	superoxide dismutase activity
MML47_19925	COG2032	superoxide dismutase activity
MML47_19930	COG2204	response regulator
MML47_19935	COG3852	Histidine kinase
MML47_19940	COG0004	ammonium transporteR
MML47_19945	COG0347	Belongs to the P(II) protein family
MML47_19950	COG0174	glutamine synthetase
MML47_19955	COG1968	undecaprenyl-diphosphatase activity
MML47_20000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MML47_20010	COG2062	phosphohistidine phosphatase, SixA
MML47_20015	COG0489	protein tyrosine kinase activity
MML47_20035	COG1396	sequence-specific DNA binding
MML47_20040	COG3550	peptidyl-serine autophosphorylation
MML47_20045	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MML47_20050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MML47_20065	COG1125	glycine betaine transport
MML47_20065	COG0517	IMP dehydrogenase activity
MML47_20080	COG1119	ATPase activity
MML47_20090	COG1473	amidohydrolase
MML47_20095	COG1752	Esterase of the alpha-beta hydrolase superfamily
MML47_20100	COG4773	Receptor
MML47_20105	COG1522	sequence-specific DNA binding
MML47_20110	COG3186	Phenylalanine-4-hydroxylase
MML47_20170	COG0739	heme binding
MML47_20185	COG2211	Major facilitator Superfamily
MML47_20190	COG0708	Exodeoxyribonuclease III
MML47_20205	COG1192	Involved in chromosome partitioning
MML47_20210	COG1475	DNA binding
MML47_20230	COG0463	Glycosyl transferase, family 2
MML47_20255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MML47_20280	COG4221	oxidoreductase activity
MML47_20285	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MML47_20285	COG2755	lipolytic protein G-D-S-L family
MML47_20305	COG1166	arginine decarboxylase activity
MML47_20310	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MML47_20350	COG0606	chelatase, subunit chli
MML47_20370	COG4943	cyclic-guanylate-specific phosphodiesterase activity
MML47_20410	COG1090	epimerase
MML47_20430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MML47_20465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MML47_20475	COG1595	DNA-templated transcription, initiation
MML47_20480	COG0753	catalase activity
MML47_20505	COG0697	spore germination
MML47_20525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MML47_20530	COG0180	Tryptophanyl-tRNA synthetase
MML47_20535	COG3237	CsbD-like
MML47_20570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MML47_20585	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MML47_20590	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MML47_20590	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MML47_20600	COG3228	Belongs to the MtfA family
MML47_20630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MML47_20720	COG0625	glutathione transferase activity
MML47_20755	COG4555	ABC transporter
MML47_20765	COG1476	TRANSCRIPTIONal
MML47_20790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MML47_20795	COG1131	(ABC) transporter
MML47_20800	COG0842	Transport permease protein
MML47_20810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MML47_20845	COG3039	Transposase
MML47_20855	COG2951	lytic endotransglycosylase activity
MML47_20890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MML47_21000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MML47_21005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MML47_21015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MML47_21015	COG0045	succinate-CoA ligase (ADP-forming) activity
MML47_21015	COG1042	CoA-binding domain protein
MML47_21025	COG2239	Acts as a magnesium transporter
MML47_21050	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MML47_21055	COG3387	PFAM Glycoside hydrolase 15-related
MML47_21070	COG3100	YcgL domain-containing protein
MML47_21075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MML47_21085	COG0463	Glycosyl transferase, family 2
MML47_21100	COG1028	Short-chain dehydrogenase reductase Sdr
MML47_21165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MML47_21215	COG0408	coproporphyrinogen oxidase activity
MML47_21220	COG2826	transposase and inactivated derivatives, IS30 family
MML47_21295	COG0210	DNA helicase
MML47_21310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MML47_21315	COG0583	DNA-binding transcription factor activity
MML47_21320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MML47_21330	COG2159	amidohydrolase
MML47_21355	COG0357	Ribosomal RNA small subunit methyltransferase G
MML47_21360	COG3540	Alkaline phosphatase
MML47_21370	COG2091	lysine biosynthetic process via aminoadipic acid
MML47_21385	COG0708	Exodeoxyribonuclease III
MML47_21410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MML47_21415	COG3162	membrane
MML47_21470	COG1028	Short-chain dehydrogenase reductase Sdr
MML47_21475	COG0179	Fumarylacetoacetate (FAA) hydrolase
MML47_21480	COG4948	Mandelate Racemase Muconate Lactonizing
MML47_21485	COG3254	rhamnose metabolic process
MML47_21490	COG0738	Major facilitator superfamily
MML47_21495	COG1414	Transcriptional regulator
MML47_21505	COG2205	protein histidine kinase activity
MML47_21515	COG3459	Glycosyltransferase 36 associated
MML47_21520	COG2211	Major facilitator Superfamily
MML47_21525	COG3265	gluconokinase activity
MML47_21535	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MML47_21560	COG0443	Heat shock 70 kDa protein
MML47_21595	COG3210	domain, Protein
MML47_21630	COG3210	domain, Protein
MML47_21655	COG3039	Transposase
MML47_21665	COG3210	domain, Protein
MML47_21700	COG3210	domain, Protein
MML47_21730	COG3210	domain, Protein
MML47_21745	COG3210	domain, Protein
MML47_21750	COG2831	hemolysin activation secretion protein
MML47_21755	COG0366	Alpha amylase catalytic
MML47_21760	COG0366	Alpha amylase catalytic
MML47_21785	COG1609	Transcriptional regulator
MML47_21810	COG1733	regulation of RNA biosynthetic process
MML47_21815	COG0702	epimerase
MML47_21845	COG0583	DNA-binding transcription factor activity
MML47_21850	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MML47_21870	COG0745	RESPONSE REGULATOR receiver
MML47_21900	COG1902	pentaerythritol trinitrate reductase activity
MML47_21905	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MML47_21915	COG2814	Major facilitator Superfamily
MML47_21920	COG0583	DNA-binding transcription factor activity
MML47_21935	COG0084	hydrolase, TatD family'
MML47_21985	COG2211	Major facilitator Superfamily
MML47_22030	COG2937	Belongs to the GPAT DAPAT family
MML47_22060	COG0284	orotidine-5'-phosphate decarboxylase activity
MML47_22065	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MML47_22070	COG3132	Protein of unknown function, DUF480
MML47_22085	COG0210	DNA helicase
MML47_22100	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MML47_22110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MML47_22145	COG3135	benzoate transporter
MML47_22165	COG0676	glucose-6-phosphate 1-epimerase activity
MML47_22180	COG0730	response to heat
MML47_22210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MML47_22215	COG0302	gtp cyclohydrolase
MML47_22250	COG0477	Major facilitator Superfamily
MML47_22285	COG2826	transposase and inactivated derivatives, IS30 family
MML47_22295	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MML47_22295	COG0546	phosphoglycolate phosphatase activity
MML47_22300	COG0277	FAD linked oxidase domain protein
MML47_22315	COG2826	transposase and inactivated derivatives, IS30 family
MML47_22340	COG0564	pseudouridine synthase activity
MML47_22385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MML47_22390	COG1074	ATP-dependent DNA helicase activity
MML47_22395	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MML47_22415	COG3039	Transposase
MML47_22430	COG1136	(ABC) transporter
MML47_22445	COG1127	ABC transporter
MML47_22450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MML47_22455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MML47_22470	COG2853	Lipoprotein
MML47_22480	COG0386	Belongs to the glutathione peroxidase family
MML47_22490	COG1322	Protein conserved in bacteria
MML47_22500	COG0531	amino acid
MML47_22525	COG2199	diguanylate cyclase activity
MML47_22525	COG2203	Gaf domain
MML47_22535	COG1929	Belongs to the glycerate kinase type-1 family
MML47_22540	COG2271	Major facilitator Superfamily
MML47_22555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MML47_22560	COG0861	Integral membrane protein TerC family
MML47_22570	COG0584	glycerophosphoryl diester phosphodiesterase
MML47_22580	COG0671	phosphoesterase, PA-phosphatase related
MML47_22585	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MML47_22590	COG0726	polysaccharide deacetylase