locus-tag	class	description
M9500_00020	COG2201	protein-glutamate methylesterase activity
M9500_00050	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M9500_00060	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M9500_00065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M9500_00080	COG1842	Phage shock protein A
M9500_00105	COG0754	glutathionylspermidine amidase activity
M9500_00165	COG0531	amino acid
M9500_00170	COG2197	response regulator
M9500_00185	COG1113	amino acid transport
M9500_00200	COG1271	oxidase subunit
M9500_00205	COG1294	oxidase, subunit
M9500_00215	COG2239	Acts as a magnesium transporter
M9500_00220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M9500_00225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M9500_00235	COG1660	Displays ATPase and GTPase activities
M9500_00240	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M9500_00245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M9500_00260	COG1137	ATPase activity
M9500_00265	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M9500_00275	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M9500_00285	COG0271	Belongs to the BolA IbaG family
M9500_00290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M9500_00310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M9500_00325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M9500_00335	COG0628	permease
M9500_00345	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M9500_00350	COG3178	'Phosphotransferase
M9500_00365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M9500_00370	COG1555	photosystem II stabilization
M9500_00410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M9500_00420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M9500_00440	COG0228	four-way junction DNA binding
M9500_00445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M9500_00450	COG0336	Belongs to the RNA methyltransferase TrmD family
M9500_00465	COG0534	Mate efflux family protein
M9500_00500	COG0542	response to heat
M9500_00535	COG4206	TonB-dependent receptor
M9500_00600	COG0019	diaminopimelate decarboxylase activity
M9500_00610	COG2814	Major facilitator Superfamily
M9500_00615	COG4264	IucA IucC family
M9500_00625	COG4772	TonB-dependent receptor
M9500_00640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M9500_00640	COG4651	solute:proton antiporter activity
M9500_00675	COG0488	(ABC) transporter
M9500_00700	COG0657	acetylesterase activity
M9500_00700	COG2755	lipolytic protein G-D-S-L family
M9500_00725	COG2207	Transcriptional regulator
M9500_00730	COG0326	Molecular chaperone. Has ATPase activity
M9500_00755	COG3328	transposase activity
M9500_00760	COG0174	glutamine synthetase
M9500_00765	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M9500_00775	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M9500_00790	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M9500_00825	COG2146	nitrite reductase [NAD(P)H] activity
M9500_00840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M9500_00845	COG0719	Fe-S assembly protein
M9500_00850	COG0396	ATPase activity
M9500_00855	COG0719	Fe-S assembly protein
M9500_00860	COG1959	2 iron, 2 sulfur cluster binding
M9500_00920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M9500_00945	COG0519	Catalyzes the synthesis of GMP from XMP
M9500_00960	COG1678	Uncharacterized ACR, COG1678
M9500_00965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M9500_00980	COG1764	response to oxidative stress
M9500_00990	COG0384	phenazine biosynthesis protein PhzF
M9500_01000	COG0527	aspartate kinase activity
M9500_01025	COG0142	geranyltranstransferase activity
M9500_01030	COG0629	single-stranded DNA binding
M9500_01035	COG2203	Gaf domain
M9500_01035	COG3706	GGDEF domain
M9500_01035	COG4251	negative regulation of phosphorylation
M9500_01035	COG5001	Diguanylate cyclase
M9500_01070	COG2879	small protein
M9500_01075	COG1966	Carbon starvation protein
M9500_01170	COG1741	Belongs to the pirin family
M9500_01180	COG1515	deoxyribonuclease V activity
M9500_01200	COG3590	peptidase
M9500_01215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M9500_01220	COG2199	diguanylate cyclase activity
M9500_01220	COG2200	EAL domain
M9500_01220	COG2202	Pas domain
M9500_01225	COG0835	chemotaxis
M9500_01230	COG0840	transmembrane signaling receptor activity
M9500_01235	COG0643	Histidine kinase
M9500_01235	COG2198	Histidine kinase
M9500_01250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M9500_01260	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M9500_01355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M9500_01360	COG0735	belongs to the Fur family
M9500_01420	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M9500_01425	COG0084	hydrolase, TatD family'
M9500_01440	COG1960	acyl-CoA dehydrogenase activity
M9500_01455	COG0367	asparagine synthase
M9500_01465	COG0305	Participates in initiation and elongation during chromosome replication
M9500_01470	COG0415	Belongs to the DNA photolyase family
M9500_01590	COG5001	Diguanylate cyclase
M9500_01590	COG5002	protein histidine kinase activity
M9500_01595	COG1187	pseudouridine synthase activity
M9500_01615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M9500_01625	COG0475	glutathione-regulated potassium exporter activity
M9500_01630	COG5000	phosphorelay sensor kinase activity
M9500_01630	COG5002	protein histidine kinase activity
M9500_01635	COG0745	RESPONSE REGULATOR receiver
M9500_01665	COG1132	(ABC) transporter
M9500_01695	COG3039	Transposase
M9500_01720	COG3039	Transposase
M9500_01755	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M9500_01765	COG4969	Belongs to the N-Me-Phe pilin family
M9500_01770	COG2194	sulfuric ester hydrolase activity
M9500_01790	COG2184	nucleotidyltransferase activity
M9500_01815	COG0045	succinate-CoA ligase (ADP-forming) activity
M9500_01820	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M9500_01835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M9500_01835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M9500_01840	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M9500_01845	COG0564	pseudouridine synthase activity
M9500_01870	COG3387	PFAM Glycoside hydrolase 15-related
M9500_01875	COG1877	trehalose-phosphatase activity
M9500_01915	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M9500_01945	COG1946	Acyl-CoA thioesterase
M9500_01960	COG0824	Thioesterase
M9500_01965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M9500_01975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M9500_01980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M9500_01985	COG0268	Binds directly to 16S ribosomal RNA
M9500_01990	COG0728	peptidoglycan biosynthetic process
M9500_01995	COG0196	riboflavin kinase activity
M9500_02005	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M9500_02010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M9500_02025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M9500_02030	COG1845	cytochrome c oxidase, subunit III
M9500_02035	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M9500_02055	COG3209	COG3209 Rhs family protein
M9500_02170	COG0632	four-way junction helicase activity
M9500_02180	COG2255	four-way junction helicase activity
M9500_02185	COG0824	Thioesterase
M9500_02195	COG0848	biopolymer transport protein
M9500_02210	COG2885	chlorophyll binding
M9500_02220	COG0602	queuosine metabolic process
M9500_02225	COG1187	pseudouridine synthase activity
M9500_02280	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M9500_02305	COG0514	ATP-dependent DNA helicase (RecQ)
M9500_02310	COG0783	Belongs to the Dps family
M9500_02315	COG1643	Atp-dependent helicase
M9500_02370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M9500_02380	COG1215	transferase activity, transferring glycosyl groups
M9500_02385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M9500_02395	COG1199	ATP-dependent helicase activity
M9500_02405	COG1397	ADP-ribosylglycohydrolase
M9500_02415	COG0189	ligase activity
M9500_02430	COG0835	chemotaxis
M9500_02435	COG0840	transmembrane signaling receptor activity
M9500_02440	COG0643	Histidine kinase
M9500_02440	COG0784	Response regulator, receiver
M9500_02440	COG2198	Histidine kinase
M9500_02465	COG2304	oxidoreductase activity
M9500_02470	COG2304	oxidoreductase activity
M9500_02480	COG1446	asparaginase
M9500_02485	COG3142	Participates in the control of copper homeostasis
M9500_02535	COG3537	Alpha-1,2-mannosidase
M9500_02610	COG1472	Belongs to the glycosyl hydrolase 3 family
M9500_02620	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M9500_02630	COG3858	chitin binding
M9500_02630	COG1388	LysM domain
M9500_02645	COG0837	glucose binding
M9500_02650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M9500_02660	COG0494	nUDIX hydrolase
M9500_02670	COG3956	TIGRFAM MazG family protein
M9500_02685	COG0330	HflC and HflK could
M9500_02700	COG0509	glycine decarboxylation via glycine cleavage system
M9500_02735	COG1960	acyl-CoA dehydrogenase activity
M9500_02745	COG1309	transcriptional regulator
M9500_02750	COG4771	TonB-dependent receptor
M9500_02760	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M9500_02770	COG0463	Glycosyl transferase, family 2
M9500_02795	COG1272	protein, Hemolysin III
M9500_02805	COG0739	heme binding
M9500_02810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M9500_02815	COG0626	cystathionine gamma-synthase activity
M9500_02825	COG1760	l-serine dehydratase
M9500_02840	COG2353	YceI-like domain
M9500_02850	COG2353	YceI-like domain
M9500_02920	COG1960	acyl-CoA dehydrogenase activity
M9500_02925	COG1024	Enoyl-CoA hydratase
M9500_02945	COG1024	Enoyl-CoA hydratase
M9500_02945	COG1250	3-hydroxyacyl-CoA dehydrogenase
M9500_02960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M9500_02990	COG1381	Involved in DNA repair and RecF pathway recombination
M9500_03005	COG2954	triphosphatase activity
M9500_03020	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M9500_03025	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
M9500_03030	COG3046	protein related to deoxyribodipyrimidine photolyase
M9500_03040	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M9500_03045	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M9500_03050	COG1278	Cold shock
M9500_03080	COG1201	RNA secondary structure unwinding
M9500_03085	COG1793	dna ligase
M9500_03095	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M9500_03095	COG1793	dna ligase
M9500_03125	COG0183	Belongs to the thiolase family
M9500_03165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M9500_03200	COG1047	Peptidyl-prolyl cis-trans
M9500_03215	COG2824	Alkylphosphonate utilization operon protein PhnA
M9500_03225	COG1902	pentaerythritol trinitrate reductase activity
M9500_03230	COG2814	Major facilitator Superfamily
M9500_03275	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M9500_03275	COG0392	lysyltransferase activity
M9500_03285	COG0251	oxidation-reduction process
M9500_03290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M9500_03305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M9500_03330	COG1595	DNA-templated transcription, initiation
M9500_03345	COG2878	Part of a membrane complex involved in electron transport
M9500_03355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M9500_03355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M9500_03375	COG0833	amino acid
M9500_03380	COG2040	homocysteine
M9500_03395	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M9500_03430	COG0529	Catalyzes the synthesis of activated sulfate
M9500_03430	COG2895	sulfate adenylyltransferase (ATP) activity
M9500_03475	COG1981	membrane
M9500_03500	COG1131	(ABC) transporter
M9500_03505	COG4771	TonB-dependent receptor
M9500_03520	COG0825	malonyl-CoA metabolic process
M9500_03540	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9500_03545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M9500_03565	COG0750	zinc metalloprotease
M9500_03575	COG0575	Belongs to the CDS family
M9500_03585	COG0233	cytoplasmic translational termination
M9500_03600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M9500_03660	COG1393	Belongs to the ArsC family
M9500_03675	COG0367	asparagine synthase
M9500_03685	COG4774	siderophore transport
M9500_03720	COG1566	PFAM secretion protein HlyD family protein
M9500_03725	COG2814	Major facilitator Superfamily
M9500_03765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M9500_03775	COG1960	acyl-CoA dehydrogenase activity
M9500_03805	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M9500_03825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M9500_03830	COG0443	Heat shock 70 kDa protein
M9500_03835	COG0484	heat shock protein binding
M9500_03840	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M9500_03845	COG0287	Prephenate dehydrogenase
M9500_03845	COG1605	Chorismate mutase
M9500_03870	COG1132	(ABC) transporter
M9500_03895	COG0567	Dehydrogenase, E1 component
M9500_03905	COG2850	peptidyl-arginine hydroxylation
M9500_03985	COG1131	(ABC) transporter
M9500_03990	COG1725	Transcriptional regulator
M9500_04000	COG0386	Belongs to the glutathione peroxidase family
M9500_04020	COG2900	Belongs to the SlyX family
M9500_04035	COG1609	Transcriptional regulator
M9500_04045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M9500_04055	COG1410	methionine synthase
M9500_04055	COG0646	methionine synthase
M9500_04060	COG0646	methionine synthase
M9500_04060	COG1410	methionine synthase
M9500_04065	COG2226	methyltransferase
M9500_04070	COG1960	acyl-CoA dehydrogenase activity
M9500_04095	COG0557	exoribonuclease II activity
M9500_04115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M9500_04125	COG3039	Transposase
M9500_04145	COG3328	transposase activity
M9500_04170	COG3039	Transposase
M9500_04220	COG3039	Transposase
M9500_04270	COG3039	Transposase
M9500_04280	COG0583	DNA-binding transcription factor activity
M9500_04330	COG2201	protein-glutamate methylesterase activity
M9500_04360	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M9500_04370	COG0531	amino acid
M9500_04375	COG0531	amino acid
M9500_04385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M9500_04390	COG0277	FAD linked oxidase domain protein
M9500_04455	COG0436	Aminotransferase
M9500_04485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M9500_04490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M9500_04495	COG2350	Protein conserved in bacteria
M9500_04530	COG1175	transmembrane transport
M9500_04535	COG0395	ABC-type sugar transport system, permease component
M9500_04560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M9500_04570	COG2957	Belongs to the agmatine deiminase family
M9500_04585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M9500_04590	COG0539	negative regulation of cytoplasmic translation
M9500_04595	COG0776	regulation of translation
M9500_04605	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M9500_04610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M9500_04620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M9500_04640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M9500_04655	COG3002	Belongs to the UPF0753 family
M9500_04660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M9500_04665	COG0583	DNA-binding transcription factor activity
M9500_04680	COG1028	Short-chain dehydrogenase reductase Sdr
M9500_04695	COG0583	DNA-binding transcription factor activity
M9500_04720	COG1914	H( )-stimulated, divalent metal cation uptake system
M9500_04740	COG0668	transmembrane transport
M9500_04795	COG1183	phosphatidylcholine synthase activity
M9500_04805	COG3243	poly(R)-hydroxyalkanoic acid synthase
M9500_04820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M9500_04820	COG0723	plastoquinol--plastocyanin reductase activity
M9500_04830	COG2183	response to ionizing radiation
M9500_04845	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
M9500_04860	COG0671	phosphoesterase, PA-phosphatase related
M9500_04885	COG0697	spore germination
M9500_04915	COG1012	belongs to the aldehyde dehydrogenase family
M9500_04950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M9500_04965	COG0124	histidyl-tRNA synthetase
M9500_04985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M9500_05000	COG0131	Imidazoleglycerol-phosphate dehydratase
M9500_05000	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M9500_05010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M9500_05065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M9500_05160	COG0745	RESPONSE REGULATOR receiver
M9500_05165	COG2205	protein histidine kinase activity
M9500_05185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M9500_05215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M9500_05215	COG3453	Protein conserved in bacteria
M9500_05220	COG0725	ABC transporter, periplasmic molybdate-binding protein
M9500_05225	COG4149	molybdate abc transporter
M9500_05230	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M9500_05250	COG0642	Histidine kinase
M9500_05265	COG1028	Short-chain dehydrogenase reductase Sdr
M9500_05275	COG1022	Amp-dependent synthetase and ligase
M9500_05300	COG1376	ErfK ybiS ycfS ynhG family protein
M9500_05305	COG0739	heme binding
M9500_05315	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M9500_05320	COG1301	dicarboxylic acid transport
M9500_05340	COG2304	oxidoreductase activity
M9500_05360	COG0714	Associated with various cellular activities
M9500_05410	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M9500_05440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M9500_05475	COG1561	YicC-like family, N-terminal region
M9500_05480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M9500_05495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M9500_05520	COG3293	Transposase
M9500_05535	COG0006	proline dipeptidase activity
M9500_05560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M9500_05580	COG2912	Transglutaminase-like superfamily
M9500_05585	COG1773	rubredoxin
M9500_05590	COG0352	thiamine-phosphate diphosphorylase activity
M9500_05620	COG0280	phosphate acetyltransferase
M9500_05620	COG0281	malic enzyme
M9500_05640	COG4191	Histidine kinase
M9500_05655	COG0583	DNA-binding transcription factor activity
M9500_05675	COG2197	response regulator
M9500_05685	COG0642	Histidine kinase
M9500_05700	COG2851	Citrate transporter
M9500_05705	COG1028	Short-chain dehydrogenase reductase Sdr
M9500_05710	COG1609	Transcriptional regulator
M9500_05720	COG2211	Major facilitator Superfamily
M9500_05770	COG0726	polysaccharide deacetylase
M9500_05775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M9500_05800	COG3039	Transposase
M9500_05845	COG0242	peptide deformylase activity
M9500_05865	COG0714	Associated with various cellular activities
M9500_05885	COG0537	adenosine 5'-monophosphoramidase activity
M9500_05915	COG0314	molybdopterin synthase activity
M9500_05920	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M9500_05925	COG0315	cyclic pyranopterin monophosphate synthase activity
M9500_05935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M9500_05940	COG1234	tRNA 3'-trailer cleavage
M9500_05945	COG3642	lipopolysaccharide core region biosynthetic process
M9500_05950	COG0859	PFAM glycosyl transferase family 9
M9500_05960	COG0582	viral genome integration into host DNA
M9500_06040	COG0631	protein serine/threonine phosphatase activity
M9500_06050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M9500_06075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M9500_06115	COG0544	peptidyl-prolyl cis-trans isomerase activity
M9500_06165	COG0473	3-isopropylmalate dehydrogenase activity
M9500_06190	COG0584	glycerophosphoryl diester phosphodiesterase
M9500_06210	COG3039	Transposase
M9500_06340	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M9500_06360	COG1217	gtp-binding protein TYPA
M9500_06365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M9500_06375	COG0625	glutathione transferase activity
M9500_06390	COG3781	membrane
M9500_06400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M9500_06430	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
M9500_06450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M9500_06475	COG3710	Transcriptional regulator
M9500_06480	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M9500_06490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M9500_06525	COG0066	3-isopropylmalate dehydratase activity
M9500_06530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M9500_06550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M9500_06555	COG1538	Outer membrane efflux protein
M9500_06560	COG1519	Transferase
M9500_06565	COG1560	Kdo2-lipid A biosynthetic process
M9500_06615	COG0308	aminopeptidase N
M9500_06630	COG0330	HflC and HflK could
M9500_06635	COG0330	HflC and HflK could
M9500_06655	COG0678	peroxiredoxin activity
M9500_06665	COG2826	transposase and inactivated derivatives, IS30 family
M9500_06740	COG3829	transcription factor binding
M9500_06775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M9500_06780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M9500_06790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M9500_06795	COG1028	Short-chain dehydrogenase reductase Sdr
M9500_06820	COG1399	metal-binding, possibly nucleic acid-binding protein
M9500_06860	COG1518	maintenance of DNA repeat elements
M9500_06865	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M9500_06915	COG2188	Transcriptional regulator
M9500_06930	COG1450	Type ii and iii secretion system protein
M9500_06945	COG3166	PFAM Fimbrial assembly family protein
M9500_06950	COG3156	type II secretion system protein K
M9500_06955	COG4795	General secretion pathway protein
M9500_06960	COG2165	general secretion pathway protein
M9500_06965	COG4970	Tfp pilus assembly protein FimT
M9500_06970	COG2165	general secretion pathway protein
M9500_06975	COG1459	type II secretion system
M9500_06985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M9500_07005	COG5295	Hep Hag repeat protein
M9500_07010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M9500_07010	COG0047	phosphoribosylformylglycinamidine synthase activity
M9500_07035	COG0795	lipopolysaccharide-transporting ATPase activity
M9500_07045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M9500_07060	COG0525	valine-tRNA ligase activity
M9500_07115	COG3039	Transposase
M9500_07140	COG1183	phosphatidylcholine synthase activity
M9500_07150	COG0442	prolyl-tRNA aminoacylation
M9500_07165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M9500_07170	COG1127	ABC transporter
M9500_07175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M9500_07175	COG3218	ABC-type transport auxiliary lipoprotein component
M9500_07210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M9500_07215	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M9500_07215	COG0662	Cupin 2, conserved barrel domain protein
M9500_07240	COG2086	electron transfer activity
M9500_07265	COG3328	transposase activity
M9500_07305	COG0626	cystathionine gamma-synthase activity
M9500_07335	COG0625	glutathione transferase activity
M9500_07345	COG0513	Belongs to the DEAD box helicase family
M9500_07350	COG0720	synthase
M9500_07360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M9500_07365	COG1956	GAF domain-containing protein
M9500_07400	COG0339	signal peptide processing
M9500_07455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M9500_07460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9500_07510	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M9500_07515	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M9500_07520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M9500_07525	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M9500_07535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M9500_07545	COG0356	it plays a direct role in the translocation of protons across the membrane
M9500_07575	COG0508	dehydrogenase complex catalyzes the overall conversion of
M9500_07605	COG2011	ABC-type metal ion transport system permease component
M9500_07615	COG0697	spore germination
M9500_07650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M9500_07655	COG1187	pseudouridine synthase activity
M9500_07660	COG2813	Specifically methylates the guanine in position
M9500_07690	COG2205	protein histidine kinase activity
M9500_07690	COG2202	Pas domain
M9500_07715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M9500_07765	COG0745	RESPONSE REGULATOR receiver
M9500_07780	COG1404	Belongs to the peptidase S8 family
M9500_07795	COG0842	Transport permease protein
M9500_07800	COG1131	(ABC) transporter
M9500_07805	COG0025	NhaP-type Na H and K H
M9500_07815	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M9500_07825	COG1573	uracil-dna glycosylase
M9500_07835	COG3384	dioxygenase
M9500_07850	COG0667	Aldo Keto reductase
M9500_07865	COG3590	peptidase
M9500_07885	COG0531	amino acid
M9500_07900	COG2972	Histidine kinase
M9500_07925	COG2204	response regulator
M9500_07935	COG1271	oxidase subunit
M9500_07940	COG1294	oxidase, subunit
M9500_08165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M9500_08175	COG1560	Kdo2-lipid A biosynthetic process
M9500_08225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M9500_08225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M9500_08230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M9500_08235	COG0242	peptide deformylase activity
M9500_08240	COG1652	LysM domain
M9500_08245	COG0758	DNA mediated transformation
M9500_08250	COG2922	Belongs to the Smg family
M9500_08265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M9500_08265	COG1754	DNA topoisomerase type I activity
M9500_08270	COG0009	L-threonylcarbamoyladenylate synthase
M9500_08285	COG1028	Short-chain dehydrogenase reductase Sdr
M9500_08295	COG0616	signal peptide processing
M9500_08300	COG0534	Mate efflux family protein
M9500_08320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M9500_08355	COG1324	tolerance protein
M9500_08365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M9500_08370	COG0511	ligase activity, forming carbon-carbon bonds
M9500_08380	COG0439	Biotin carboxylase
M9500_08420	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M9500_08455	COG0419	ATPase involved in DNA repair
M9500_08465	COG0151	Belongs to the GarS family
M9500_08470	COG1136	(ABC) transporter
M9500_08470	COG0577	efflux transmembrane transporter activity
M9500_08480	COG1289	transmembrane transporter activity
M9500_08495	COG2814	Major facilitator Superfamily
M9500_08510	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M9500_08550	COG0745	RESPONSE REGULATOR receiver
M9500_08595	COG0739	heme binding
M9500_08610	COG2211	Major facilitator Superfamily
M9500_08615	COG0708	Exodeoxyribonuclease III
M9500_08630	COG1192	Involved in chromosome partitioning
M9500_08635	COG1475	DNA binding
M9500_08650	COG0463	Glycosyl transferase, family 2
M9500_08675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M9500_08680	COG2003	Belongs to the UPF0758 family
M9500_08685	COG0018	arginyl-trna synthetase
M9500_08700	COG4221	oxidoreductase activity
M9500_08725	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M9500_08730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M9500_08745	COG3485	protocatechuate 3,4-dioxygenase
M9500_08750	COG3485	protocatechuate 3,4-dioxygenase
M9500_08785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M9500_08790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M9500_08800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M9500_08800	COG0045	succinate-CoA ligase (ADP-forming) activity
M9500_08800	COG1042	CoA-binding domain protein
M9500_08810	COG2239	Acts as a magnesium transporter
M9500_08825	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M9500_08830	COG3387	PFAM Glycoside hydrolase 15-related
M9500_08845	COG3100	YcgL domain-containing protein
M9500_08850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M9500_08860	COG0463	Glycosyl transferase, family 2
M9500_08875	COG1028	Short-chain dehydrogenase reductase Sdr
M9500_08885	COG0156	8-amino-7-oxononanoate synthase activity
M9500_08890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M9500_08895	COG1040	competence protein
M9500_08900	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M9500_08910	COG0628	permease
M9500_08920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M9500_08930	COG1595	DNA-templated transcription, initiation
M9500_08935	COG0753	catalase activity
M9500_08980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M9500_08985	COG0180	Tryptophanyl-tRNA synthetase
M9500_08990	COG3237	CsbD-like
M9500_09025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M9500_09040	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M9500_09045	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M9500_09045	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M9500_09055	COG3228	Belongs to the MtfA family
M9500_09085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M9500_09125	COG1199	ATP-dependent helicase activity
M9500_09165	COG0583	DNA-binding transcription factor activity
M9500_09210	COG0625	glutathione transferase activity
M9500_09245	COG4555	ABC transporter
M9500_09255	COG1476	TRANSCRIPTIONal
M9500_09280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M9500_09285	COG1131	(ABC) transporter
M9500_09290	COG0842	Transport permease protein
M9500_09300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M9500_09380	COG3039	Transposase
M9500_09390	COG1181	Belongs to the D-alanine--D-alanine ligase family
M9500_09400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M9500_09410	COG0564	pseudouridine synthase activity
M9500_09440	COG0339	signal peptide processing
M9500_09475	COG3254	rhamnose metabolic process
M9500_09480	COG0738	Major facilitator superfamily
M9500_09485	COG1414	Transcriptional regulator
M9500_09495	COG2205	protein histidine kinase activity
M9500_09505	COG3459	Glycosyltransferase 36 associated
M9500_09510	COG2211	Major facilitator Superfamily
M9500_09515	COG3265	gluconokinase activity
M9500_09525	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M9500_09600	COG1127	ABC transporter
M9500_09605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M9500_09610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M9500_09625	COG2853	Lipoprotein
M9500_09645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M9500_09710	COG0676	glucose-6-phosphate 1-epimerase activity
M9500_09715	COG3039	Transposase
M9500_09740	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M9500_09750	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M9500_09760	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M9500_09765	COG1064	alcohol dehydrogenase
M9500_09810	COG1522	sequence-specific DNA binding
M9500_09815	COG3186	Phenylalanine-4-hydroxylase
M9500_09850	COG0604	alcohol dehydrogenase
M9500_09850	COG3321	synthase
M9500_09850	COG1028	Short-chain dehydrogenase reductase Sdr
M9500_09855	COG2937	Belongs to the GPAT DAPAT family
M9500_09890	COG0284	orotidine-5'-phosphate decarboxylase activity
M9500_09895	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M9500_09900	COG3132	Protein of unknown function, DUF480
M9500_09915	COG0210	DNA helicase
M9500_09930	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M9500_09955	COG1028	Short-chain dehydrogenase reductase Sdr
M9500_09980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M9500_10045	COG1166	arginine decarboxylase activity
M9500_10050	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M9500_10090	COG0606	chelatase, subunit chli
M9500_10135	COG0366	Alpha amylase catalytic
M9500_10140	COG0366	Alpha amylase catalytic
M9500_10165	COG1609	Transcriptional regulator
M9500_10215	COG0493	'glutamate synthase
M9500_10220	COG0070	glutamate synthase
M9500_10220	COG0069	glutamate synthase activity
M9500_10220	COG0067	glutamate synthase
M9500_10280	COG1205	dead DEAH box helicase
M9500_10280	COG1111	helicase
M9500_10285	COG1272	protein, Hemolysin III
M9500_10325	COG1136	(ABC) transporter
M9500_10385	COG2826	transposase and inactivated derivatives, IS30 family
M9500_10410	COG3039	Transposase
M9500_10420	COG1090	epimerase
M9500_10440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M9500_10550	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M9500_10625	COG1511	domain protein
M9500_10625	COG3264	Mechanosensitive ion channel
M9500_10640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M9500_10645	COG2354	Protein conserved in bacteria
M9500_10650	COG1649	PFAM Uncharacterised BCR, COG1649
M9500_10670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M9500_10695	COG0702	epimerase
M9500_10710	COG1858	cytochrome C peroxidase
M9500_10755	COG3039	Transposase
M9500_10805	COG0513	Belongs to the DEAD box helicase family
M9500_10810	COG3039	Transposase
M9500_10850	COG1136	(ABC) transporter
M9500_10860	COG3039	Transposase
M9500_10870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M9500_10900	COG1304	FMN binding
M9500_10905	COG3039	Transposase
M9500_10920	COG4772	TonB-dependent receptor
M9500_10930	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M9500_10940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M9500_10980	COG0501	Belongs to the peptidase M48B family
M9500_10990	COG0187	DNA topoisomerase II activity
M9500_11005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M9500_11025	COG0726	polysaccharide deacetylase
M9500_11035	COG0671	phosphoesterase, PA-phosphatase related
M9500_11045	COG0584	glycerophosphoryl diester phosphodiesterase
M9500_11055	COG0861	Integral membrane protein TerC family
M9500_11060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M9500_11075	COG2271	Major facilitator Superfamily
M9500_11080	COG1929	Belongs to the glycerate kinase type-1 family
M9500_11175	COG0477	Major facilitator Superfamily
M9500_11200	COG0302	gtp cyclohydrolase
M9500_11205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M9500_11250	COG2234	aminopeptidase activity
M9500_11260	COG4942	peptidase
M9500_11265	COG0793	Belongs to the peptidase S41A family
M9500_11310	COG0386	Belongs to the glutathione peroxidase family
M9500_11320	COG1322	Protein conserved in bacteria
M9500_11330	COG0531	amino acid
M9500_11360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M9500_11365	COG0583	DNA-binding transcription factor activity
M9500_11370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M9500_11420	COG3540	Alkaline phosphatase
M9500_11430	COG2091	lysine biosynthetic process via aminoadipic acid
M9500_11445	COG0708	Exodeoxyribonuclease III
M9500_11460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M9500_11465	COG3162	membrane
M9500_11525	COG1028	Short-chain dehydrogenase reductase Sdr
M9500_11530	COG0179	Fumarylacetoacetate (FAA) hydrolase
M9500_11535	COG4948	Mandelate Racemase Muconate Lactonizing
M9500_11540	COG4807	Protein conserved in bacteria
M9500_11545	COG1643	Atp-dependent helicase
M9500_11555	COG1187	pseudouridine synthase activity
M9500_11565	COG0667	Aldo Keto reductase
M9500_11570	COG2130	NADP-dependent
M9500_11575	COG0656	L-ascorbic acid biosynthetic process
M9500_11600	COG3039	Transposase
M9500_11615	COG1752	Esterase of the alpha-beta hydrolase superfamily
M9500_11625	COG1119	ATPase activity
M9500_11640	COG1125	glycine betaine transport
M9500_11640	COG0517	IMP dehydrogenase activity
M9500_11655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M9500_11660	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
M9500_11665	COG3550	peptidyl-serine autophosphorylation
M9500_11670	COG1396	sequence-specific DNA binding
M9500_11690	COG0489	protein tyrosine kinase activity
M9500_11695	COG2062	phosphohistidine phosphatase, SixA
M9500_11705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M9500_11745	COG1968	undecaprenyl-diphosphatase activity
M9500_11750	COG0174	glutamine synthetase
M9500_11755	COG0347	Belongs to the P(II) protein family
M9500_11760	COG0004	ammonium transporteR
M9500_11765	COG3852	Histidine kinase
M9500_11770	COG2204	response regulator
M9500_11775	COG2032	superoxide dismutase activity
M9500_11780	COG2032	superoxide dismutase activity
M9500_11815	COG1196	nuclear chromosome segregation
M9500_11830	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M9500_11835	COG1074	ATP-dependent DNA helicase activity
M9500_11845	COG3549	Plasmid maintenance system killer
M9500_11930	COG1764	response to oxidative stress
M9500_11935	COG1846	Transcriptional regulator
M9500_12030	COG2211	Major facilitator Superfamily
M9500_12055	COG3693	PFAM glycoside hydrolase, family 10
M9500_12080	COG0246	Mannitol dehydrogenase
M9500_12085	COG1472	Belongs to the glycosyl hydrolase 3 family
M9500_12095	COG4948	Mandelate Racemase Muconate Lactonizing
M9500_12105	COG3661	Belongs to the glycosyl hydrolase 67 family
M9500_12155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M9500_12165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M9500_12175	COG0805	protein transport
M9500_12185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M9500_12185	COG0519	Catalyzes the synthesis of GMP from XMP
M9500_12200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M9500_12215	COG0457	Tetratricopeptide repeat
M9500_12220	COG4771	TonB-dependent receptor
M9500_12240	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M9500_12260	COG0523	cobalamin synthesis protein
M9500_12315	COG1960	acyl-CoA dehydrogenase activity
M9500_12320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M9500_12325	COG4770	biotin carboxylase activity
M9500_12395	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M9500_12445	COG0084	hydrolase, TatD family'
M9500_12460	COG0583	DNA-binding transcription factor activity
M9500_12465	COG2814	Major facilitator Superfamily
M9500_12475	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M9500_12480	COG1902	pentaerythritol trinitrate reductase activity
M9500_12510	COG0745	RESPONSE REGULATOR receiver
M9500_12525	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M9500_12530	COG0583	DNA-binding transcription factor activity
M9500_12560	COG0702	epimerase
M9500_12565	COG1733	regulation of RNA biosynthetic process
M9500_12615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M9500_12665	COG2911	Protein conserved in bacteria
M9500_12670	COG0729	surface antigen
M9500_12685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M9500_12690	COG3118	belongs to the thioredoxin family
M9500_12700	COG2884	Cell division ATP-binding protein ftsE
M9500_12705	COG2177	Part of the ABC transporter FtsEX involved in
M9500_12710	COG2201	protein-glutamate methylesterase activity
M9500_12730	COG1252	NADH dehydrogenase
M9500_12760	COG0459	protein refolding
M9500_12780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M9500_12810	COG3386	PFAM SMP-30 Gluconolaconase
M9500_12825	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M9500_12855	COG2353	YceI-like domain
M9500_12945	COG0408	coproporphyrinogen oxidase activity
M9500_12955	COG3039	Transposase
M9500_12980	COG0129	dihydroxy-acid dehydratase activity
M9500_12990	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M9500_13040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M9500_13045	COG0318	PFAM AMP-dependent synthetase and ligase
M9500_13050	COG0727	PFAM Uncharacterised protein family (UPF0153)
M9500_13055	COG0596	Alpha beta hydrolase
M9500_13070	COG3177	Filamentation induced by cAMP protein fic
M9500_13075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M9500_13090	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M9500_13115	COG4191	Histidine kinase
M9500_13120	COG0028	Belongs to the TPP enzyme family
M9500_13135	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M9500_13140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M9500_13175	COG5383	Protein conserved in bacteria
M9500_13185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M9500_13190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9500_13195	COG1473	amidohydrolase
M9500_13205	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M9500_13205	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M9500_13215	COG3328	transposase activity
M9500_13275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M9500_13290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M9500_13295	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M9500_13305	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
M9500_13310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M9500_13315	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M9500_13365	COG1565	acr, cog1565
M9500_13365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M9500_13380	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M9500_13445	COG0358	DNA primase activity
M9500_13450	COG1295	ribonuclease BN
M9500_13460	COG1610	YqeY-like protein
M9500_13470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M9500_13475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M9500_13510	COG2133	pyrroloquinoline quinone binding
M9500_13515	COG4682	membrane
M9500_13550	COG0531	amino acid
M9500_13585	COG4948	Mandelate Racemase Muconate Lactonizing
M9500_13595	COG3023	N-Acetylmuramoyl-L-alanine amidase
M9500_13600	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
M9500_13630	COG3039	Transposase
M9500_13680	COG0183	Belongs to the thiolase family
M9500_13725	COG3483	tryptophan 2,3-dioxygenase activity
M9500_13730	COG3104	oligopeptide transport
M9500_13750	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M9500_13760	COG1320	monovalent cation:proton antiporter activity
M9500_13765	COG2212	antiporter activity
M9500_13775	COG0651	ATP synthesis coupled electron transport
M9500_13780	COG1006	Multisubunit Na H antiporter MnhC subunit
M9500_13785	COG2111	Na H antiporter
M9500_13785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M9500_13815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M9500_13825	COG0456	acetyltransferase
M9500_13855	COG4221	oxidoreductase activity
M9500_13915	COG0697	spore germination
M9500_13920	COG4305	rare lipoprotein A
M9500_13925	COG5297	Belongs to the glycosyl hydrolase family 6
M9500_13935	COG1113	amino acid transport
M9500_13945	COG0598	Magnesium transport protein CorA
M9500_14015	COG5297	Belongs to the glycosyl hydrolase family 6
M9500_14015	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M9500_14020	COG0659	secondary active sulfate transmembrane transporter activity
M9500_14055	COG3275	phosphorelay sensor kinase activity
M9500_14065	COG0181	hydroxymethylbilane synthase activity
M9500_14090	COG1505	serine-type exopeptidase activity
M9500_14105	COG0436	Aminotransferase
M9500_14135	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M9500_14165	COG0308	aminopeptidase N
M9500_14170	COG2199	diguanylate cyclase activity
M9500_14220	COG3039	Transposase
M9500_14225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M9500_14230	COG1077	Cell shape determining protein MreB Mrl
M9500_14235	COG1792	Involved in formation and maintenance of cell shape
M9500_14250	COG0772	Belongs to the SEDS family
M9500_14325	COG2951	lytic endotransglycosylase activity
M9500_14330	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M9500_14335	COG1686	Belongs to the peptidase S11 family
M9500_14350	COG2921	Belongs to the UPF0250 family
M9500_14390	COG1051	belongs to the nudix hydrolase family
M9500_14390	COG1056	cytidyltransferase-related domain
M9500_14425	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M9500_14430	COG0673	inositol 2-dehydrogenase activity
M9500_14435	COG2823	Periplasmic or secreted lipoprotein
M9500_14440	COG4251	negative regulation of phosphorylation
M9500_14445	COG0784	Response regulator, receiver
M9500_14450	COG4191	Histidine kinase
M9500_14455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M9500_14505	COG2188	Transcriptional regulator
M9500_14515	COG1609	Transcriptional regulator
M9500_14520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M9500_14525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M9500_14535	COG1215	transferase activity, transferring glycosyl groups
M9500_14540	COG1649	PFAM Uncharacterised BCR, COG1649
M9500_14540	COG0726	polysaccharide deacetylase
M9500_14590	COG3039	Transposase
M9500_14645	COG3039	Transposase
M9500_14655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M9500_14660	COG3039	Transposase
M9500_14695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M9500_14755	COG2205	protein histidine kinase activity
M9500_14780	COG3791	Glutathione-dependent formaldehyde-activating
M9500_14805	COG0488	(ABC) transporter
M9500_14825	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M9500_14845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M9500_14845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M9500_14865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M9500_14870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M9500_14875	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M9500_14895	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M9500_14900	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M9500_14910	COG2205	protein histidine kinase activity
M9500_14915	COG0745	RESPONSE REGULATOR receiver
M9500_14920	COG0277	FAD linked oxidase domain protein
M9500_14925	COG1988	membrane-bound metal-dependent
M9500_14930	COG0792	nuclease activity
M9500_14965	COG0275	rRNA processing
M9500_14970	COG3116	cell division
M9500_14985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M9500_15005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M9500_15010	COG1181	Belongs to the D-alanine--D-alanine ligase family
M9500_15015	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M9500_15030	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M9500_15040	COG4942	peptidase
M9500_15040	COG1388	LysM domain
M9500_15055	COG0494	nUDIX hydrolase
M9500_15075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M9500_15085	COG0604	alcohol dehydrogenase
M9500_15085	COG1028	Short-chain dehydrogenase reductase Sdr
M9500_15085	COG3321	synthase
M9500_15140	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M9500_15180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M9500_15195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M9500_15205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M9500_15210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M9500_15220	COG0667	Aldo Keto reductase
M9500_15270	COG2175	clavaminate synthase activity
M9500_15280	COG4181	ATPase activity
M9500_15295	COG0642	Histidine kinase
M9500_15310	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M9500_15330	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M9500_15355	COG2967	ApaG domain
M9500_15360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M9500_15370	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M9500_15385	COG0123	including yeast histone deacetylase and acetoin utilization protein
M9500_15390	COG2096	Adenosyltransferase
M9500_15400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M9500_15405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M9500_15445	COG0583	DNA-binding transcription factor activity
M9500_15450	COG0318	PFAM AMP-dependent synthetase and ligase
M9500_15460	COG1024	Enoyl-CoA hydratase
M9500_15480	COG3386	PFAM SMP-30 Gluconolaconase
M9500_15610	COG0446	pyridine nucleotide-disulphide oxidoreductase
M9500_15610	COG1902	pentaerythritol trinitrate reductase activity
M9500_15615	COG0604	alcohol dehydrogenase
M9500_15640	COG0156	8-amino-7-oxononanoate synthase activity
M9500_15645	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M9500_15650	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M9500_15655	COG4208	sulfate ABC transporter
M9500_15660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M9500_15690	COG0406	alpha-ribazole phosphatase activity
M9500_15700	COG0285	dihydrofolate synthase activity
M9500_15720	COG2833	Protein of unknown function (DUF455)
M9500_15740	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9500_15745	COG0671	phosphoesterase, PA-phosphatase related
M9500_15750	COG0438	transferase activity, transferring glycosyl groups
M9500_15760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M9500_15775	COG4783	chaperone-mediated protein folding
M9500_15840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M9500_15845	COG0583	DNA-binding transcription factor activity
M9500_15850	COG3634	alkyl hydroperoxide reductase activity
M9500_15860	COG2890	protein-(glutamine-N5) methyltransferase activity
M9500_15910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M9500_15910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M9500_15925	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M9500_15950	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M9500_15975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M9500_15985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M9500_16015	COG1295	ribonuclease BN
M9500_16020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M9500_16040	COG0521	Mo-molybdopterin cofactor biosynthetic process
M9500_16050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M9500_16065	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M9500_16080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M9500_16090	COG0193	aminoacyl-tRNA hydrolase activity
M9500_16095	COG0012	GTP binding
M9500_16125	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M9500_16130	COG0250	Participates in transcription elongation, termination and antitermination
M9500_16135	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M9500_16145	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M9500_16150	COG0222	ribosome binding
M9500_16155	COG0085	RNA polymerase activity
M9500_16160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M9500_16165	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M9500_16170	COG0049	tRNA binding
M9500_16190	COG0051	transcription antitermination factor activity, RNA binding
M9500_16195	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M9500_16200	COG0088	Forms part of the polypeptide exit tunnel
M9500_16205	COG0089	rRNA binding
M9500_16220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M9500_16230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M9500_16235	COG0255	Belongs to the universal ribosomal protein uL29 family
M9500_16240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M9500_16245	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M9500_16255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M9500_16285	COG1841	ribosomal large subunit assembly
M9500_16295	COG0201	protein transport
M9500_16305	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M9500_16310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M9500_16320	COG0203	ribosomal protein L17
M9500_16380	COG3551	Protein conserved in bacteria
M9500_16410	COG2194	sulfuric ester hydrolase activity
M9500_16420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M9500_16425	COG0745	RESPONSE REGULATOR receiver
M9500_16430	COG0642	Histidine kinase
M9500_16440	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M9500_16445	COG2894	cell division
M9500_16460	COG4585	Histidine kinase
M9500_16465	COG2197	response regulator
M9500_16490	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M9500_16590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M9500_16600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M9500_16665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M9500_16720	COG3179	chitinase
M9500_16910	COG0732	type I restriction modification DNA specificity domain
M9500_16925	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
M9500_16945	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M9500_16950	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
M9500_16955	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
M9500_16970	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M9500_17065	COG1297	OPT oligopeptide transporter protein
M9500_17070	COG3039	Transposase
M9500_17090	COG0823	Involved in the tonB-independent uptake of proteins
M9500_17090	COG1506	peptidase
M9500_17110	COG1917	Cupin 2, conserved barrel domain protein
M9500_17110	COG2207	Transcriptional regulator
M9500_17135	COG3039	Transposase
M9500_17155	COG0753	catalase activity
M9500_17195	COG0469	pyruvate kinase activity
M9500_17200	COG3588	fructose-bisphosphate aldolase
M9500_17205	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M9500_17255	COG0784	Response regulator, receiver
M9500_17255	COG2198	Histidine kinase
M9500_17255	COG2205	protein histidine kinase activity
M9500_17275	COG0175	sulfate reduction
M9500_17280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M9500_17285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M9500_17290	COG0175	sulfate reduction
M9500_17295	COG2895	sulfate adenylyltransferase (ATP) activity
M9500_17295	COG0529	Catalyzes the synthesis of activated sulfate
M9500_17305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M9500_17310	COG0308	aminopeptidase N
M9500_17330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M9500_17335	COG2272	Belongs to the type-B carboxylesterase lipase family
M9500_17355	COG1970	mechanosensitive ion channel activity
M9500_17370	COG3039	Transposase
M9500_17390	COG3273	potassium ion transport
M9500_17390	COG0471	metal ion transport
M9500_17400	COG2022	thiamine diphosphate biosynthetic process
M9500_17490	COG3039	Transposase
M9500_17555	COG3118	belongs to the thioredoxin family
M9500_17580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M9500_17605	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M9500_17630	COG2968	Membrane
M9500_17645	COG3164	Protein of unknown function
M9500_17655	COG0312	modulator of DNA gyrase
M9500_17660	COG3028	Belongs to the UPF0307 family
M9500_17665	COG0312	modulator of DNA gyrase
M9500_17690	COG0142	geranyltranstransferase activity
M9500_17695	COG1722	exodeoxyribonuclease VII activity
M9500_17700	COG0037	tRNA processing
M9500_17705	COG1785	Belongs to the alkaline phosphatase family
M9500_17725	COG0791	NLP P60 protein
M9500_17730	COG0791	NLP P60 protein
M9500_17735	COG1047	Peptidyl-prolyl cis-trans
M9500_17740	COG2311	Membrane
M9500_17745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M9500_17785	COG0489	protein tyrosine kinase activity
M9500_17790	COG0717	Belongs to the dCTP deaminase family
M9500_17820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M9500_17860	COG2890	protein-(glutamine-N5) methyltransferase activity
M9500_17865	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M9500_17875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M9500_17895	COG0101	tRNA pseudouridine synthase activity
M9500_17900	COG0135	phosphoribosylanthranilate isomerase activity
M9500_17925	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M9500_17930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M9500_17975	COG0149	triose-phosphate isomerase activity
M9500_17990	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9500_18000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9500_18005	COG0649	NAD binding
M9500_18010	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M9500_18015	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M9500_18020	COG1034	ATP synthesis coupled electron transport
M9500_18025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M9500_18055	COG1007	ATP synthesis coupled electron transport
M9500_18065	COG0779	Required for maturation of 30S ribosomal subunits
M9500_18070	COG0195	Participates in both transcription termination and antitermination
M9500_18090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M9500_18095	COG1185	polyribonucleotide nucleotidyltransferase activity
M9500_18130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M9500_18140	COG2095	MarC family integral membrane protein
M9500_18155	COG1611	Belongs to the LOG family
M9500_18195	COG4969	Belongs to the N-Me-Phe pilin family
M9500_18200	COG0556	nucleotide-excision repair
M9500_18235	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M9500_18305	COG0438	transferase activity, transferring glycosyl groups
M9500_18310	COG0438	transferase activity, transferring glycosyl groups
M9500_18320	COG0438	transferase activity, transferring glycosyl groups
M9500_18360	COG3040	lipid binding
M9500_18440	COG3039	Transposase
M9500_18445	COG4191	Histidine kinase
M9500_18445	COG0784	Response regulator, receiver
M9500_18470	COG0552	protein localization to endoplasmic reticulum
M9500_18480	COG3938	Belongs to the proline racemase family
M9500_18485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M9500_18500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M9500_18510	COG0006	proline dipeptidase activity
M9500_18525	COG0531	amino acid
M9500_18555	COG4206	TonB-dependent receptor
M9500_18645	COG0746	molybdenum cofactor guanylyltransferase activity
M9500_18675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M9500_18675	COG1648	precorrin-2 dehydrogenase activity
M9500_18705	COG3039	Transposase
M9500_18715	COG3039	Transposase
M9500_18740	COG3039	Transposase
M9500_18755	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M9500_18775	COG3039	Transposase
M9500_18780	COG1054	Belongs to the UPF0176 family
M9500_18795	COG1530	ribonuclease E activity
M9500_18820	COG2154	pterin-4-alpha-carbinolamine dehydratase
M9500_18825	COG0316	Belongs to the HesB IscA family
M9500_18825	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M9500_18875	COG3039	Transposase
M9500_18980	COG0631	protein serine/threonine phosphatase activity
M9500_18985	COG0515	serine threonine protein kinase
M9500_19020	COG1858	cytochrome C peroxidase
M9500_19075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9500_19130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M9500_19150	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M9500_19165	COG1595	DNA-templated transcription, initiation
M9500_19215	COG2244	polysaccharide biosynthetic process
M9500_19245	COG2264	protein methyltransferase activity
M9500_19255	COG0438	transferase activity, transferring glycosyl groups
M9500_19275	COG1136	(ABC) transporter
M9500_19280	COG1132	(ABC) transporter
M9500_19290	COG0477	Major facilitator Superfamily
M9500_19300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M9500_19315	COG1253	flavin adenine dinucleotide binding
M9500_19325	COG0306	phosphate transporter
M9500_19330	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M9500_19355	COG0504	CTP synthase activity
M9500_19360	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M9500_19370	COG0148	phosphopyruvate hydratase activity
M9500_19375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M9500_19390	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M9500_19400	COG2840	Smr protein MutS2
M9500_19405	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M9500_19410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M9500_19415	COG1238	metal cluster binding
M9500_19430	COG1534	Rna-binding protein
M9500_19435	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M9500_19445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M9500_19460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M9500_19465	COG1546	Belongs to the CinA family
M9500_19480	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M9500_19485	COG2137	regulation of response to DNA damage stimulus
M9500_19490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M9500_19495	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M9500_19510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M9500_19520	COG1741	Belongs to the pirin family
M9500_19525	COG0583	DNA-binding transcription factor activity
M9500_19550	COG0351	phosphomethylpyrimidine kinase
M9500_19560	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M9500_19565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M9500_19580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M9500_19590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M9500_19595	COG3734	2-keto-3-deoxy-galactonokinase
M9500_19605	COG4948	Mandelate Racemase Muconate Lactonizing
M9500_19610	COG0800	Aldolase
M9500_19625	COG1501	Belongs to the glycosyl hydrolase 31 family
M9500_19645	COG0477	Major facilitator Superfamily
M9500_19710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M9500_19715	COG2258	MOSC domain
M9500_19725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M9500_19730	COG0505	Belongs to the CarA family
M9500_19740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M9500_19745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M9500_19755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M9500_19765	COG3039	Transposase
M9500_19775	COG3039	Transposase
M9500_19825	COG0784	Response regulator, receiver
M9500_19825	COG2198	Histidine kinase
M9500_19825	COG2205	protein histidine kinase activity
M9500_19830	COG1024	Enoyl-CoA hydratase
M9500_19835	COG0318	PFAM AMP-dependent synthetase and ligase
M9500_19865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M9500_19895	COG0840	transmembrane signaling receptor activity
M9500_19915	COG0835	chemotaxis
M9500_19930	COG0840	transmembrane signaling receptor activity
M9500_19935	COG0840	transmembrane signaling receptor activity
M9500_19940	COG0840	transmembrane signaling receptor activity
M9500_19945	COG0840	transmembrane signaling receptor activity
M9500_19955	COG0840	transmembrane signaling receptor activity
M9500_19965	COG0840	transmembrane signaling receptor activity
M9500_19995	COG0745	RESPONSE REGULATOR receiver
M9500_20005	COG0835	chemotaxis
M9500_20015	COG1360	Flagellar Motor Protein
M9500_20020	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M9500_20040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M9500_20050	COG4771	TonB-dependent receptor
M9500_20075	COG3039	Transposase
M9500_20120	COG3409	Peptidoglycan-binding domain 1 protein
M9500_20120	COG3501	Rhs element vgr protein
M9500_20195	COG3039	Transposase
M9500_20210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M9500_20210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M9500_20215	COG1105	Belongs to the carbohydrate kinase PfkB family
M9500_20220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M9500_20220	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M9500_20225	COG1609	Transcriptional regulator
M9500_20245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M9500_20250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9500_20260	COG2902	Dehydrogenase
M9500_20265	COG3039	Transposase
M9500_20275	COG5002	protein histidine kinase activity
M9500_20275	COG2205	protein histidine kinase activity
M9500_20275	COG0784	Response regulator, receiver
M9500_20280	COG2733	membrane
M9500_20290	COG1121	(ABC) transporter
M9500_20295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M9500_20300	COG2223	nitrite transmembrane transporter activity
M9500_20310	COG0243	molybdopterin cofactor binding
M9500_20320	COG0477	Major facilitator Superfamily
M9500_20330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M9500_20335	COG0174	glutamine synthetase
M9500_20370	COG3842	ATPase activity
M9500_20390	COG1012	belongs to the aldehyde dehydrogenase family
M9500_20450	COG0741	lytic transglycosylase activity
M9500_20455	COG0723	plastoquinol--plastocyanin reductase activity
M9500_20460	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M9500_20470	COG0625	glutathione transferase activity
M9500_20495	COG2094	Belongs to the DNA glycosylase MPG family
M9500_20505	COG3328	transposase activity
M9500_20570	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M9500_20595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M9500_20600	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M9500_20600	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M9500_20605	COG0802	atpase or kinase
M9500_20610	COG0860	N-Acetylmuramoyl-L-alanine amidase
M9500_20615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M9500_20635	COG1028	Short-chain dehydrogenase reductase Sdr
M9500_20655	COG2081	HI0933 family
M9500_20660	COG4681	YaeQ
M9500_20665	COG1671	Belongs to the UPF0178 family
M9500_20675	COG0625	glutathione transferase activity
M9500_20695	COG0513	Belongs to the DEAD box helicase family
M9500_20700	COG0488	(ABC) transporter
M9500_20720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M9500_20725	COG0483	inositol monophosphate 1-phosphatase activity
M9500_20740	COG3300	MHYT domain
M9500_20740	COG5001	Diguanylate cyclase
M9500_20745	COG1509	lysine 2,3-aminomutase activity
M9500_20760	COG0402	S-adenosylhomocysteine deaminase activity
M9500_20765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M9500_20790	COG4677	pectinesterase activity
M9500_20800	COG3039	Transposase
M9500_20835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M9500_20860	COG2166	iron-sulfur cluster assembly
M9500_20875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M9500_20880	COG0137	argininosuccinate synthase activity
M9500_20890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M9500_20895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M9500_20910	COG0165	Argininosuccinate lyase
M9500_20930	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M9500_20965	COG3039	Transposase
M9500_20980	COG4988	ABC transporter
M9500_20985	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M9500_20995	COG3039	Transposase
M9500_21070	COG3039	Transposase
M9500_21080	COG3039	Transposase
M9500_21090	COG3039	Transposase
M9500_21100	COG3209	COG3209 Rhs family protein
M9500_21110	COG3039	Transposase
M9500_21140	COG0643	Histidine kinase
M9500_21140	COG0784	Response regulator, receiver
M9500_21140	COG2198	Histidine kinase
M9500_21195	COG1684	flagellar biosynthetic protein fliR
M9500_21210	COG3190	flagellar
M9500_21260	COG1677	Flagellar hook-basal body complex protein FliE
M9500_21290	COG1028	Short-chain dehydrogenase reductase Sdr
M9500_21300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M9500_21320	COG2201	protein-glutamate methylesterase activity
M9500_21355	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M9500_21360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M9500_21395	COG4787	bacterial-type flagellum-dependent cell motility
M9500_21405	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M9500_21410	COG1558	bacterial-type flagellum-dependent cell motility
M9500_21420	COG0835	chemotaxis
M9500_21420	COG0784	Response regulator, receiver
M9500_21440	COG5002	protein histidine kinase activity
M9500_21450	COG4585	Histidine kinase
M9500_21455	COG5001	Diguanylate cyclase
M9500_21480	COG0482	sulfurtransferase activity
M9500_21495	COG0542	response to heat
M9500_21530	COG0492	ferredoxin-NADP+ reductase activity
M9500_21535	COG1674	ftsk spoiiie
M9500_21555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M9500_21575	COG0038	chloride channel
M9500_21580	COG0183	Belongs to the thiolase family
M9500_21585	COG1250	3-hydroxyacyl-CoA dehydrogenase
M9500_21585	COG1024	Enoyl-CoA hydratase
M9500_21600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M9500_21610	COG1426	Protein conserved in bacteria
M9500_21620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M9500_21630	COG0303	'Molybdopterin
M9500_21660	COG3039	Transposase
M9500_21695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M9500_21715	COG0742	ribosomal rna small subunit methyltransferase
M9500_21720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M9500_21730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M9500_21735	COG0405	Gamma-glutamyltransferase
M9500_21810	COG0343	queuine tRNA-ribosyltransferase activity
M9500_21815	COG1862	Preprotein translocase
M9500_21820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M9500_21825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M9500_21835	COG3039	Transposase
M9500_21855	COG3328	transposase activity
M9500_21870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M9500_21880	COG0704	Plays a role in the regulation of phosphate uptake
M9500_21895	COG0573	inorganic phosphate transmembrane transporter activity
M9500_21900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M9500_21940	COG3039	Transposase
M9500_21960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M9500_21970	COG1024	Enoyl-CoA hydratase
M9500_21985	COG0494	nUDIX hydrolase
M9500_22030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M9500_22030	COG0116	Belongs to the methyltransferase superfamily
M9500_22055	COG0667	Aldo Keto reductase
M9500_22065	COG2925	Exonuclease
M9500_22090	COG0288	reversible hydration of carbon dioxide
M9500_22120	COG0316	Belongs to the HesB IscA family
M9500_22125	COG0360	Binds together with S18 to 16S ribosomal RNA
M9500_22135	COG0359	binds to the 23S rRNA
M9500_22145	COG3115	cell septum assembly
M9500_22165	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M9500_22180	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M9500_22205	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M9500_22215	COG2986	histidine ammonia-lyase
M9500_22220	COG1228	amidohydrolase
M9500_22260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M9500_22270	COG0077	Prephenate dehydratase
M9500_22270	COG1605	Chorismate mutase
M9500_22275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M9500_22305	COG4566	intracellular signal transduction
M9500_22350	COG0860	N-Acetylmuramoyl-L-alanine amidase
M9500_22355	COG1469	GTP cyclohydrolase I activity
M9500_22365	COG0617	tRNA 3'-terminal CCA addition
M9500_22380	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M9500_22410	COG1472	Belongs to the glycosyl hydrolase 3 family
M9500_22425	COG5001	Diguanylate cyclase
M9500_22425	COG4251	negative regulation of phosphorylation
M9500_22425	COG3706	GGDEF domain
M9500_22425	COG2203	Gaf domain
M9500_22510	COG0386	Belongs to the glutathione peroxidase family
M9500_22585	COG5002	protein histidine kinase activity
M9500_22585	COG0784	Response regulator, receiver
M9500_22585	COG2205	protein histidine kinase activity
M9500_22615	COG0800	Aldolase
M9500_22620	COG0129	dihydroxy-acid dehydratase activity
M9500_22625	COG0363	glucosamine-6-phosphate deaminase activity
M9500_22635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M9500_22650	COG0354	folic acid binding
M9500_22665	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M9500_22680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M9500_22695	COG4591	ABC-type transport system involved in lipoprotein release permease component
M9500_22720	COG0811	peptide transport
M9500_22735	COG1663	tetraacyldisaccharide 4'-kinase activity
M9500_22745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M9500_22755	COG0322	excinuclease ABC activity
M9500_22810	COG3039	Transposase