locus-tag	class	description
GKO49_00115	COG3039	Transposase
GKO49_00120	COG0513	Belongs to the DEAD box helicase family
GKO49_00185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GKO49_00190	COG3265	gluconokinase activity
GKO49_00195	COG2211	Major facilitator Superfamily
GKO49_00200	COG3459	Glycosyltransferase 36 associated
GKO49_00210	COG2205	protein histidine kinase activity
GKO49_00225	COG1414	Transcriptional regulator
GKO49_00230	COG0738	Major facilitator superfamily
GKO49_00235	COG3254	rhamnose metabolic process
GKO49_00265	COG0339	signal peptide processing
GKO49_00295	COG0564	pseudouridine synthase activity
GKO49_00315	COG1181	Belongs to the D-alanine--D-alanine ligase family
GKO49_00380	COG3551	Protein conserved in bacteria
GKO49_00410	COG2194	sulfuric ester hydrolase activity
GKO49_00420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GKO49_00425	COG0745	RESPONSE REGULATOR receiver
GKO49_00430	COG0642	Histidine kinase
GKO49_00440	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GKO49_00445	COG2894	cell division
GKO49_00465	COG4585	Histidine kinase
GKO49_00470	COG2197	response regulator
GKO49_00485	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GKO49_00515	COG2963	transposase activity
GKO49_00630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKO49_00635	COG3501	Rhs element vgr protein
GKO49_00640	COG3501	Rhs element vgr protein
GKO49_00705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GKO49_00710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GKO49_00715	COG2350	Protein conserved in bacteria
GKO49_00755	COG1175	transmembrane transport
GKO49_00760	COG0395	ABC-type sugar transport system, permease component
GKO49_00785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GKO49_00795	COG2957	Belongs to the agmatine deiminase family
GKO49_00805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GKO49_00815	COG0539	negative regulation of cytoplasmic translation
GKO49_00830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GKO49_00835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GKO49_00845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GKO49_00885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GKO49_00890	COG0583	DNA-binding transcription factor activity
GKO49_00920	COG0583	DNA-binding transcription factor activity
GKO49_00935	COG2201	protein-glutamate methylesterase activity
GKO49_00940	COG1914	H( )-stimulated, divalent metal cation uptake system
GKO49_00945	COG1321	iron dependent repressor
GKO49_00950	COG0590	tRNA wobble adenosine to inosine editing
GKO49_00960	COG0668	transmembrane transport
GKO49_01005	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_01010	COG1183	phosphatidylcholine synthase activity
GKO49_01020	COG3243	poly(R)-hydroxyalkanoic acid synthase
GKO49_01035	COG0723	plastoquinol--plastocyanin reductase activity
GKO49_01035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GKO49_01045	COG2183	response to ionizing radiation
GKO49_01060	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GKO49_01075	COG0671	phosphoesterase, PA-phosphatase related
GKO49_01140	COG3706	GGDEF domain
GKO49_01165	COG1247	-acetyltransferase
GKO49_01205	COG1862	Preprotein translocase
GKO49_01215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GKO49_01245	COG4206	TonB-dependent receptor
GKO49_01310	COG0019	diaminopimelate decarboxylase activity
GKO49_01320	COG2814	Major facilitator Superfamily
GKO49_01325	COG4264	IucA IucC family
GKO49_01335	COG4772	TonB-dependent receptor
GKO49_01350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GKO49_01350	COG4651	solute:proton antiporter activity
GKO49_01375	COG0488	(ABC) transporter
GKO49_01400	COG0657	acetylesterase activity
GKO49_01400	COG2755	lipolytic protein G-D-S-L family
GKO49_01415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GKO49_01430	COG2040	homocysteine
GKO49_01435	COG0833	amino acid
GKO49_01465	COG2878	Part of a membrane complex involved in electron transport
GKO49_01480	COG1595	DNA-templated transcription, initiation
GKO49_01505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GKO49_01520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GKO49_01525	COG0251	oxidation-reduction process
GKO49_01535	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GKO49_01535	COG0392	lysyltransferase activity
GKO49_01575	COG2814	Major facilitator Superfamily
GKO49_01580	COG1902	pentaerythritol trinitrate reductase activity
GKO49_01590	COG2824	Alkylphosphonate utilization operon protein PhnA
GKO49_01670	COG0303	'Molybdopterin
GKO49_01675	COG1160	GTP binding
GKO49_01680	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GKO49_01690	COG1426	Protein conserved in bacteria
GKO49_01705	COG0105	UTP biosynthetic process
GKO49_01715	COG1250	3-hydroxyacyl-CoA dehydrogenase
GKO49_01715	COG1024	Enoyl-CoA hydratase
GKO49_01720	COG0183	Belongs to the thiolase family
GKO49_01730	COG0038	chloride channel
GKO49_01750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GKO49_01770	COG1674	ftsk spoiiie
GKO49_01775	COG0492	ferredoxin-NADP+ reductase activity
GKO49_01795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GKO49_01800	COG0542	response to heat
GKO49_01805	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GKO49_01815	COG0482	sulfurtransferase activity
GKO49_01840	COG5001	Diguanylate cyclase
GKO49_01845	COG4585	Histidine kinase
GKO49_01855	COG5002	protein histidine kinase activity
GKO49_01875	COG0835	chemotaxis
GKO49_01875	COG0784	Response regulator, receiver
GKO49_01885	COG1558	bacterial-type flagellum-dependent cell motility
GKO49_01890	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GKO49_01895	COG1749	Flagellar hook protein flgE
GKO49_01900	COG4787	bacterial-type flagellum-dependent cell motility
GKO49_01910	COG4786	Flagellar basal body rod
GKO49_01940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GKO49_01945	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GKO49_01975	COG2201	protein-glutamate methylesterase activity
GKO49_01980	COG2204	response regulator
GKO49_01995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GKO49_02005	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_02040	COG1677	Flagellar hook-basal body complex protein FliE
GKO49_02090	COG3190	flagellar
GKO49_02100	COG1987	bacterial-type flagellum assembly
GKO49_02105	COG1684	flagellar biosynthetic protein fliR
GKO49_02110	COG3300	MHYT domain
GKO49_02110	COG5001	Diguanylate cyclase
GKO49_02115	COG5001	Diguanylate cyclase
GKO49_02115	COG3300	MHYT domain
GKO49_02130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GKO49_02140	COG0455	bacterial-type flagellum organization
GKO49_02160	COG0643	Histidine kinase
GKO49_02160	COG2198	Histidine kinase
GKO49_02190	COG3209	COG3209 Rhs family protein
GKO49_02285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GKO49_02290	COG4988	ABC transporter
GKO49_02310	COG4677	pectinesterase activity
GKO49_02325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKO49_02365	COG0386	Belongs to the glutathione peroxidase family
GKO49_02375	COG1725	Transcriptional regulator
GKO49_02380	COG1131	(ABC) transporter
GKO49_02460	COG2850	peptidyl-arginine hydroxylation
GKO49_02495	COG1132	(ABC) transporter
GKO49_02510	COG0583	DNA-binding transcription factor activity
GKO49_02525	COG1605	Chorismate mutase
GKO49_02525	COG0287	Prephenate dehydrogenase
GKO49_02530	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GKO49_02555	COG0497	DNA recombination
GKO49_02565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GKO49_02570	COG2914	Belongs to the UPF0125 (RnfH) family
GKO49_02580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GKO49_02595	COG1960	acyl-CoA dehydrogenase activity
GKO49_02650	COG2814	Major facilitator Superfamily
GKO49_02655	COG1566	PFAM secretion protein HlyD family protein
GKO49_02695	COG4774	siderophore transport
GKO49_02705	COG0367	asparagine synthase
GKO49_02720	COG1393	Belongs to the ArsC family
GKO49_02740	COG0024	Methionine aminopeptidase
GKO49_02810	COG0575	Belongs to the CDS family
GKO49_02820	COG0750	zinc metalloprotease
GKO49_02880	COG4771	TonB-dependent receptor
GKO49_03040	COG0745	RESPONSE REGULATOR receiver
GKO49_03045	COG0277	FAD linked oxidase domain protein
GKO49_03050	COG1988	membrane-bound metal-dependent
GKO49_03095	COG3116	cell division
GKO49_03110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GKO49_03115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GKO49_03135	COG1181	Belongs to the D-alanine--D-alanine ligase family
GKO49_03140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GKO49_03165	COG1388	LysM domain
GKO49_03165	COG4942	peptidase
GKO49_03170	COG0653	protein targeting
GKO49_03180	COG0494	nUDIX hydrolase
GKO49_03195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GKO49_03205	COG3321	synthase
GKO49_03205	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_03205	COG0604	alcohol dehydrogenase
GKO49_03260	COG2226	methyltransferase
GKO49_03300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GKO49_03315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GKO49_03325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKO49_03330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GKO49_03340	COG0667	Aldo Keto reductase
GKO49_03385	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GKO49_03395	COG2175	clavaminate synthase activity
GKO49_03405	COG4181	ATPase activity
GKO49_03420	COG0642	Histidine kinase
GKO49_03440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GKO49_03485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GKO49_03505	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GKO49_03520	COG0123	including yeast histone deacetylase and acetoin utilization protein
GKO49_03525	COG2096	Adenosyltransferase
GKO49_03535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GKO49_03540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GKO49_03560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GKO49_03615	COG1966	Carbon starvation protein
GKO49_03620	COG2879	small protein
GKO49_03655	COG5001	Diguanylate cyclase
GKO49_03655	COG4251	negative regulation of phosphorylation
GKO49_03655	COG3706	GGDEF domain
GKO49_03655	COG2203	Gaf domain
GKO49_03660	COG0629	single-stranded DNA binding
GKO49_03665	COG0142	geranyltranstransferase activity
GKO49_03690	COG0527	aspartate kinase activity
GKO49_03700	COG0384	phenazine biosynthesis protein PhzF
GKO49_03705	COG3039	Transposase
GKO49_03715	COG1764	response to oxidative stress
GKO49_03745	COG0519	Catalyzes the synthesis of GMP from XMP
GKO49_03775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GKO49_03815	COG0693	protein deglycase activity
GKO49_03835	COG1959	2 iron, 2 sulfur cluster binding
GKO49_03840	COG0719	Fe-S assembly protein
GKO49_03845	COG0396	ATPase activity
GKO49_03850	COG0719	Fe-S assembly protein
GKO49_03855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GKO49_03895	COG2207	Transcriptional regulator
GKO49_03900	COG0326	Molecular chaperone. Has ATPase activity
GKO49_03925	COG3328	transposase activity
GKO49_03935	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GKO49_03945	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GKO49_03995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GKO49_04035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKO49_04035	COG3453	Protein conserved in bacteria
GKO49_04040	COG0725	ABC transporter, periplasmic molybdate-binding protein
GKO49_04045	COG4149	molybdate abc transporter
GKO49_04050	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GKO49_04070	COG0642	Histidine kinase
GKO49_04075	COG0745	RESPONSE REGULATOR receiver
GKO49_04085	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_04095	COG1022	Amp-dependent synthetase and ligase
GKO49_04125	COG1376	ErfK ybiS ycfS ynhG family protein
GKO49_04130	COG0739	heme binding
GKO49_04140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GKO49_04145	COG1301	dicarboxylic acid transport
GKO49_04165	COG2304	oxidoreductase activity
GKO49_04185	COG0714	Associated with various cellular activities
GKO49_04235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GKO49_04250	COG0254	rRNA binding
GKO49_04260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GKO49_04270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GKO49_04295	COG1561	YicC-like family, N-terminal region
GKO49_04315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GKO49_04345	COG0006	proline dipeptidase activity
GKO49_04370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GKO49_04380	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GKO49_04390	COG2912	Transglutaminase-like superfamily
GKO49_04395	COG1773	rubredoxin
GKO49_04400	COG0352	thiamine-phosphate diphosphorylase activity
GKO49_04425	COG0281	malic enzyme
GKO49_04425	COG0280	phosphate acetyltransferase
GKO49_04445	COG4191	Histidine kinase
GKO49_04460	COG0583	DNA-binding transcription factor activity
GKO49_04475	COG2197	response regulator
GKO49_04480	COG1840	ABC-type Fe3 transport system, periplasmic component
GKO49_04485	COG0642	Histidine kinase
GKO49_04500	COG2851	Citrate transporter
GKO49_04505	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_04510	COG1609	Transcriptional regulator
GKO49_04545	COG1162	GTPase activity
GKO49_04570	COG0726	polysaccharide deacetylase
GKO49_04575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GKO49_04620	COG0242	peptide deformylase activity
GKO49_04640	COG0714	Associated with various cellular activities
GKO49_04660	COG0537	adenosine 5'-monophosphoramidase activity
GKO49_04690	COG0314	molybdopterin synthase activity
GKO49_04695	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GKO49_04710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GKO49_04715	COG1234	tRNA 3'-trailer cleavage
GKO49_04725	COG0859	PFAM glycosyl transferase family 9
GKO49_04735	COG0582	viral genome integration into host DNA
GKO49_04770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GKO49_04820	COG1858	cytochrome C peroxidase
GKO49_04850	COG0515	serine threonine protein kinase
GKO49_04855	COG0631	protein serine/threonine phosphatase activity
GKO49_04890	COG3501	Rhs element vgr protein
GKO49_04970	COG3039	Transposase
GKO49_05000	COG0473	3-isopropylmalate dehydrogenase activity
GKO49_05005	COG1877	trehalose-phosphatase activity
GKO49_05010	COG3387	PFAM Glycoside hydrolase 15-related
GKO49_05035	COG0564	pseudouridine synthase activity
GKO49_05040	COG0564	pseudouridine synthase activity
GKO49_05065	COG3387	PFAM Glycoside hydrolase 15-related
GKO49_05070	COG1877	trehalose-phosphatase activity
GKO49_05125	COG1595	DNA-templated transcription, initiation
GKO49_05135	COG1946	Acyl-CoA thioesterase
GKO49_05150	COG0824	Thioesterase
GKO49_05155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GKO49_05175	COG0268	Binds directly to 16S ribosomal RNA
GKO49_05180	COG0728	peptidoglycan biosynthetic process
GKO49_05185	COG0196	riboflavin kinase activity
GKO49_05215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GKO49_05220	COG1845	cytochrome c oxidase, subunit III
GKO49_05225	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GKO49_05250	COG0137	argininosuccinate synthase activity
GKO49_05260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GKO49_05265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GKO49_05330	COG1271	oxidase subunit
GKO49_05355	COG0471	metal ion transport
GKO49_05355	COG3273	potassium ion transport
GKO49_05415	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GKO49_05415	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GKO49_05445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GKO49_05465	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GKO49_05495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GKO49_05495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GKO49_05545	COG1846	Transcriptional regulator
GKO49_05550	COG1764	response to oxidative stress
GKO49_05635	COG3549	Plasmid maintenance system killer
GKO49_05645	COG1074	ATP-dependent DNA helicase activity
GKO49_05650	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GKO49_05695	COG2032	superoxide dismutase activity
GKO49_05700	COG2032	superoxide dismutase activity
GKO49_05705	COG2204	response regulator
GKO49_05710	COG3852	Histidine kinase
GKO49_05715	COG0004	ammonium transporteR
GKO49_05720	COG0347	Belongs to the P(II) protein family
GKO49_05725	COG0174	glutamine synthetase
GKO49_05775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GKO49_05785	COG2062	phosphohistidine phosphatase, SixA
GKO49_05790	COG0489	protein tyrosine kinase activity
GKO49_05815	COG1396	sequence-specific DNA binding
GKO49_05820	COG3550	peptidyl-serine autophosphorylation
GKO49_05825	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GKO49_05830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKO49_05845	COG0517	IMP dehydrogenase activity
GKO49_05845	COG1125	glycine betaine transport
GKO49_05860	COG1119	ATPase activity
GKO49_05870	COG1752	Esterase of the alpha-beta hydrolase superfamily
GKO49_05910	COG2937	Belongs to the GPAT DAPAT family
GKO49_05950	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GKO49_05970	COG0210	DNA helicase
GKO49_05985	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GKO49_06010	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_06070	COG3501	Rhs element vgr protein
GKO49_06105	COG3039	Transposase
GKO49_06110	COG3039	Transposase
GKO49_06135	COG0316	Belongs to the HesB IscA family
GKO49_06135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GKO49_06140	COG2154	pterin-4-alpha-carbinolamine dehydratase
GKO49_06150	COG0428	transporter
GKO49_06155	COG0428	transporter
GKO49_06160	COG3064	Membrane
GKO49_06170	COG1530	ribonuclease E activity
GKO49_06205	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GKO49_06240	COG3039	Transposase
GKO49_06275	COG1648	precorrin-2 dehydrogenase activity
GKO49_06275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GKO49_06300	COG0746	molybdenum cofactor guanylyltransferase activity
GKO49_06325	COG3039	Transposase
GKO49_06375	COG4206	TonB-dependent receptor
GKO49_06425	COG0531	amino acid
GKO49_06440	COG0006	proline dipeptidase activity
GKO49_06450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GKO49_06465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GKO49_06470	COG3938	Belongs to the proline racemase family
GKO49_06480	COG0552	protein localization to endoplasmic reticulum
GKO49_06500	COG4191	Histidine kinase
GKO49_06500	COG0784	Response regulator, receiver
GKO49_06600	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GKO49_06615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GKO49_06650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GKO49_06650	COG0140	phosphoribosyl-ATP diphosphatase activity
GKO49_06715	COG0124	histidyl-tRNA synthetase
GKO49_06735	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GKO49_06775	COG1012	belongs to the aldehyde dehydrogenase family
GKO49_06800	COG0697	spore germination
GKO49_06805	COG1794	racemase activity, acting on amino acids and derivatives
GKO49_06825	COG0386	Belongs to the glutathione peroxidase family
GKO49_06910	COG3706	GGDEF domain
GKO49_06910	COG2203	Gaf domain
GKO49_06910	COG5001	Diguanylate cyclase
GKO49_06910	COG4251	negative regulation of phosphorylation
GKO49_06930	COG1472	Belongs to the glycosyl hydrolase 3 family
GKO49_06960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GKO49_06965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GKO49_06975	COG0617	tRNA 3'-terminal CCA addition
GKO49_06990	COG0860	N-Acetylmuramoyl-L-alanine amidase
GKO49_07020	COG1132	(ABC) transporter
GKO49_07040	COG0436	Aminotransferase
GKO49_07045	COG4133	protoheme IX ABC transporter activity
GKO49_07060	COG4133	protoheme IX ABC transporter activity
GKO49_07065	COG0436	Aminotransferase
GKO49_07105	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GKO49_07110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GKO49_07110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GKO49_07120	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GKO49_07165	COG2194	sulfuric ester hydrolase activity
GKO49_07170	COG4969	Belongs to the N-Me-Phe pilin family
GKO49_07180	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GKO49_07200	COG0542	response to heat
GKO49_07235	COG0534	Mate efflux family protein
GKO49_07285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GKO49_07295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GKO49_07340	COG1555	photosystem II stabilization
GKO49_07345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GKO49_07360	COG3178	'Phosphotransferase
GKO49_07365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GKO49_07375	COG0628	permease
GKO49_07400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GKO49_07430	COG0271	Belongs to the BolA IbaG family
GKO49_07440	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GKO49_07450	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GKO49_07455	COG1137	ATPase activity
GKO49_07470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKO49_07495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKO49_07500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GKO49_07505	COG2239	Acts as a magnesium transporter
GKO49_07515	COG1294	oxidase, subunit
GKO49_07520	COG1271	oxidase subunit
GKO49_07540	COG1113	amino acid transport
GKO49_07555	COG2197	response regulator
GKO49_07560	COG0531	amino acid
GKO49_07615	COG0789	Transcriptional regulator
GKO49_07630	COG0754	glutathionylspermidine amidase activity
GKO49_07655	COG1842	Phage shock protein A
GKO49_07675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GKO49_07685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GKO49_07745	COG3039	Transposase
GKO49_07765	COG1294	oxidase, subunit
GKO49_07770	COG1271	oxidase subunit
GKO49_07820	COG2972	Histidine kinase
GKO49_07835	COG0531	amino acid
GKO49_07855	COG3590	peptidase
GKO49_07865	COG0667	Aldo Keto reductase
GKO49_07880	COG3384	dioxygenase
GKO49_07890	COG1573	uracil-dna glycosylase
GKO49_07900	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GKO49_07915	COG0025	NhaP-type Na H and K H
GKO49_07920	COG1131	(ABC) transporter
GKO49_07925	COG0842	Transport permease protein
GKO49_07945	COG1404	Belongs to the peptidase S8 family
GKO49_07960	COG0745	RESPONSE REGULATOR receiver
GKO49_08010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GKO49_08035	COG2205	protein histidine kinase activity
GKO49_08035	COG2202	Pas domain
GKO49_08065	COG2813	Specifically methylates the guanine in position
GKO49_08070	COG1187	pseudouridine synthase activity
GKO49_08075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GKO49_08110	COG0697	spore germination
GKO49_08120	COG2011	ABC-type metal ion transport system permease component
GKO49_08150	COG0508	dehydrogenase complex catalyzes the overall conversion of
GKO49_08160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GKO49_08180	COG0356	it plays a direct role in the translocation of protons across the membrane
GKO49_08260	COG1970	mechanosensitive ion channel activity
GKO49_08325	COG2197	response regulator
GKO49_08350	COG3706	GGDEF domain
GKO49_08350	COG0745	RESPONSE REGULATOR receiver
GKO49_08430	COG3386	PFAM SMP-30 Gluconolaconase
GKO49_08450	COG1024	Enoyl-CoA hydratase
GKO49_08460	COG0318	PFAM AMP-dependent synthetase and ligase
GKO49_08465	COG0583	DNA-binding transcription factor activity
GKO49_08515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GKO49_08565	COG2986	histidine ammonia-lyase
GKO49_08575	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GKO49_08615	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GKO49_08630	COG3115	cell septum assembly
GKO49_08655	COG0316	Belongs to the HesB IscA family
GKO49_08685	COG0288	reversible hydration of carbon dioxide
GKO49_08715	COG2925	Exonuclease
GKO49_08725	COG0667	Aldo Keto reductase
GKO49_08795	COG0494	nUDIX hydrolase
GKO49_08805	COG1024	Enoyl-CoA hydratase
GKO49_08815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GKO49_08850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GKO49_08855	COG0573	inorganic phosphate transmembrane transporter activity
GKO49_08870	COG0704	Plays a role in the regulation of phosphate uptake
GKO49_08880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GKO49_08915	COG2205	protein histidine kinase activity
GKO49_08930	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GKO49_08940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GKO49_08955	COG2198	Histidine kinase
GKO49_08955	COG0643	Histidine kinase
GKO49_08960	COG0840	transmembrane signaling receptor activity
GKO49_08965	COG0835	chemotaxis
GKO49_08970	COG2202	Pas domain
GKO49_08970	COG2200	EAL domain
GKO49_08970	COG2199	diguanylate cyclase activity
GKO49_08975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GKO49_08990	COG3590	peptidase
GKO49_09005	COG0588	phosphoglycerate mutase activity
GKO49_09010	COG1515	deoxyribonuclease V activity
GKO49_09020	COG1741	Belongs to the pirin family
GKO49_09060	COG1111	helicase
GKO49_09060	COG1205	dead DEAH box helicase
GKO49_09065	COG1272	protein, Hemolysin III
GKO49_09185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GKO49_09205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GKO49_09220	COG1595	DNA-templated transcription, initiation
GKO49_09270	COG2244	polysaccharide biosynthetic process
GKO49_09310	COG0438	transferase activity, transferring glycosyl groups
GKO49_09325	COG1136	(ABC) transporter
GKO49_09340	COG0477	Major facilitator Superfamily
GKO49_09350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKO49_09365	COG1253	flavin adenine dinucleotide binding
GKO49_09375	COG0306	phosphate transporter
GKO49_09430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GKO49_09450	COG2840	Smr protein MutS2
GKO49_09465	COG1238	metal cluster binding
GKO49_09480	COG1534	Rna-binding protein
GKO49_09490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GKO49_09495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GKO49_09500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GKO49_09505	COG1923	regulation of RNA biosynthetic process
GKO49_09510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GKO49_09515	COG1546	Belongs to the CinA family
GKO49_09535	COG2137	regulation of response to DNA damage stimulus
GKO49_09545	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GKO49_09565	COG0305	Participates in initiation and elongation during chromosome replication
GKO49_09570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GKO49_09595	COG1741	Belongs to the pirin family
GKO49_09600	COG0583	DNA-binding transcription factor activity
GKO49_09630	COG0351	phosphomethylpyrimidine kinase
GKO49_09640	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GKO49_09645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GKO49_09660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GKO49_09670	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GKO49_09675	COG3734	2-keto-3-deoxy-galactonokinase
GKO49_09690	COG0800	Aldolase
GKO49_09725	COG3039	Transposase
GKO49_09735	COG3039	Transposase
GKO49_09820	COG0745	RESPONSE REGULATOR receiver
GKO49_09825	COG2205	protein histidine kinase activity
GKO49_09855	COG2205	protein histidine kinase activity
GKO49_09920	COG1136	(ABC) transporter
GKO49_09960	COG0302	gtp cyclohydrolase
GKO49_09965	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GKO49_10020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GKO49_10025	COG0302	gtp cyclohydrolase
GKO49_10055	COG0477	Major facilitator Superfamily
GKO49_10065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GKO49_10180	COG1929	Belongs to the glycerate kinase type-1 family
GKO49_10185	COG2271	Major facilitator Superfamily
GKO49_10200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GKO49_10205	COG0861	Integral membrane protein TerC family
GKO49_10215	COG0584	glycerophosphoryl diester phosphodiesterase
GKO49_10225	COG0671	phosphoesterase, PA-phosphatase related
GKO49_10235	COG0726	polysaccharide deacetylase
GKO49_10240	COG0706	membrane insertase activity
GKO49_10250	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GKO49_10270	COG0187	DNA topoisomerase II activity
GKO49_10280	COG0501	Belongs to the peptidase M48B family
GKO49_10310	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GKO49_10320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GKO49_10340	COG4772	TonB-dependent receptor
GKO49_10355	COG3039	Transposase
GKO49_10380	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GKO49_10390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKO49_10480	COG2826	transposase and inactivated derivatives, IS30 family
GKO49_10505	COG3039	Transposase
GKO49_10515	COG1090	epimerase
GKO49_10525	COG0642	Histidine kinase
GKO49_10535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GKO49_10640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GKO49_10715	COG1511	domain protein
GKO49_10715	COG3264	Mechanosensitive ion channel
GKO49_10730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GKO49_10735	COG2354	Protein conserved in bacteria
GKO49_10745	COG0745	RESPONSE REGULATOR receiver
GKO49_10745	COG3706	GGDEF domain
GKO49_10760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GKO49_10785	COG0702	epimerase
GKO49_10800	COG1858	cytochrome C peroxidase
GKO49_10805	COG0366	Alpha amylase catalytic
GKO49_10810	COG0366	Alpha amylase catalytic
GKO49_10840	COG1609	Transcriptional regulator
GKO49_10870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GKO49_10970	COG1047	Peptidyl-prolyl cis-trans
GKO49_10995	COG3781	membrane
GKO49_11005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GKO49_11035	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GKO49_11045	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GKO49_11055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GKO49_11080	COG3710	Transcriptional regulator
GKO49_11165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GKO49_11170	COG1538	Outer membrane efflux protein
GKO49_11175	COG1519	Transferase
GKO49_11180	COG1560	Kdo2-lipid A biosynthetic process
GKO49_11225	COG0308	aminopeptidase N
GKO49_11230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GKO49_11240	COG0330	HflC and HflK could
GKO49_11245	COG0330	HflC and HflK could
GKO49_11265	COG0678	peroxiredoxin activity
GKO49_11275	COG2826	transposase and inactivated derivatives, IS30 family
GKO49_11300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GKO49_11305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GKO49_11310	COG0583	DNA-binding transcription factor activity
GKO49_11315	COG3634	alkyl hydroperoxide reductase activity
GKO49_11325	COG2890	protein-(glutamine-N5) methyltransferase activity
GKO49_11365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GKO49_11365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GKO49_11380	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GKO49_11400	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GKO49_11405	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GKO49_11430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GKO49_11445	COG1404	Belongs to the peptidase S8 family
GKO49_11450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GKO49_11485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GKO49_11505	COG0521	Mo-molybdopterin cofactor biosynthetic process
GKO49_11520	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GKO49_11545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GKO49_11560	COG0012	GTP binding
GKO49_11590	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GKO49_11595	COG0250	Participates in transcription elongation, termination and antitermination
GKO49_11630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GKO49_11670	COG0089	rRNA binding
GKO49_11695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GKO49_11700	COG0255	Belongs to the universal ribosomal protein uL29 family
GKO49_11705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GKO49_11725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GKO49_11745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GKO49_11750	COG1841	ribosomal large subunit assembly
GKO49_11760	COG0201	protein transport
GKO49_11765	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GKO49_11780	COG0202	RNA polymerase activity
GKO49_11785	COG0203	ribosomal protein L17
GKO49_11820	COG2234	aminopeptidase activity
GKO49_11830	COG4942	peptidase
GKO49_11835	COG0793	Belongs to the peptidase S41A family
GKO49_11885	COG0386	Belongs to the glutathione peroxidase family
GKO49_11895	COG1322	Protein conserved in bacteria
GKO49_11905	COG0531	amino acid
GKO49_11920	COG0210	DNA helicase
GKO49_11935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GKO49_11940	COG0583	DNA-binding transcription factor activity
GKO49_11945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GKO49_11955	COG2159	amidohydrolase
GKO49_11960	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GKO49_11965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GKO49_11980	COG0357	Ribosomal RNA small subunit methyltransferase G
GKO49_11985	COG3540	Alkaline phosphatase
GKO49_11995	COG2091	lysine biosynthetic process via aminoadipic acid
GKO49_12010	COG0708	Exodeoxyribonuclease III
GKO49_12025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GKO49_12030	COG3162	membrane
GKO49_12070	COG3507	Belongs to the glycosyl hydrolase 43 family
GKO49_12090	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_12095	COG0179	Fumarylacetoacetate (FAA) hydrolase
GKO49_12100	COG4948	Mandelate Racemase Muconate Lactonizing
GKO49_12105	COG4807	Protein conserved in bacteria
GKO49_12110	COG1643	Atp-dependent helicase
GKO49_12120	COG1187	pseudouridine synthase activity
GKO49_12130	COG0667	Aldo Keto reductase
GKO49_12135	COG2130	NADP-dependent
GKO49_12140	COG0656	L-ascorbic acid biosynthetic process
GKO49_12170	COG2755	lipolytic protein G-D-S-L family
GKO49_12185	COG3186	Phenylalanine-4-hydroxylase
GKO49_12190	COG1522	sequence-specific DNA binding
GKO49_12240	COG1064	alcohol dehydrogenase
GKO49_12245	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GKO49_12255	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GKO49_12265	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GKO49_12285	COG0676	glucose-6-phosphate 1-epimerase activity
GKO49_12335	COG0800	Aldolase
GKO49_12340	COG0129	dihydroxy-acid dehydratase activity
GKO49_12345	COG0363	glucosamine-6-phosphate deaminase activity
GKO49_12355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GKO49_12370	COG0354	folic acid binding
GKO49_12385	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GKO49_12400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GKO49_12415	COG4591	ABC-type transport system involved in lipoprotein release permease component
GKO49_12440	COG0811	peptide transport
GKO49_12465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GKO49_12535	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GKO49_12575	COG2211	Major facilitator Superfamily
GKO49_12595	COG3693	PFAM glycoside hydrolase, family 10
GKO49_12620	COG0246	Mannitol dehydrogenase
GKO49_12625	COG1472	Belongs to the glycosyl hydrolase 3 family
GKO49_12635	COG4948	Mandelate Racemase Muconate Lactonizing
GKO49_12645	COG3661	Belongs to the glycosyl hydrolase 67 family
GKO49_12660	COG0037	tRNA processing
GKO49_12665	COG2974	May be involved in recombination
GKO49_12690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GKO49_12700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GKO49_12710	COG0805	protein transport
GKO49_12720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GKO49_12720	COG0519	Catalyzes the synthesis of GMP from XMP
GKO49_12735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GKO49_12740	COG0752	glycyl-tRNA synthetase alpha subunit
GKO49_12750	COG0457	Tetratricopeptide repeat
GKO49_12755	COG4771	TonB-dependent receptor
GKO49_12770	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GKO49_12795	COG0523	cobalamin synthesis protein
GKO49_12850	COG1960	acyl-CoA dehydrogenase activity
GKO49_12855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GKO49_12905	COG2072	flavoprotein involved in K transport
GKO49_12925	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GKO49_12970	COG0084	hydrolase, TatD family'
GKO49_12985	COG0583	DNA-binding transcription factor activity
GKO49_12990	COG2814	Major facilitator Superfamily
GKO49_13000	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GKO49_13005	COG1902	pentaerythritol trinitrate reductase activity
GKO49_13035	COG0745	RESPONSE REGULATOR receiver
GKO49_13055	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GKO49_13060	COG0583	DNA-binding transcription factor activity
GKO49_13090	COG0702	epimerase
GKO49_13095	COG1733	regulation of RNA biosynthetic process
GKO49_13145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GKO49_13160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GKO49_13195	COG2911	Protein conserved in bacteria
GKO49_13200	COG0729	surface antigen
GKO49_13215	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GKO49_13220	COG3118	belongs to the thioredoxin family
GKO49_13230	COG2884	Cell division ATP-binding protein ftsE
GKO49_13235	COG2177	Part of the ABC transporter FtsEX involved in
GKO49_13240	COG3437	response regulator, receiver
GKO49_13250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GKO49_13260	COG1252	NADH dehydrogenase
GKO49_13280	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GKO49_13295	COG4771	TonB-dependent receptor
GKO49_13310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GKO49_13355	COG3386	PFAM SMP-30 Gluconolaconase
GKO49_13370	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GKO49_13405	COG2353	YceI-like domain
GKO49_13475	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GKO49_13480	COG3023	N-Acetylmuramoyl-L-alanine amidase
GKO49_13490	COG4948	Mandelate Racemase Muconate Lactonizing
GKO49_13515	COG0531	amino acid
GKO49_13540	COG4682	membrane
GKO49_13545	COG2133	pyrroloquinoline quinone binding
GKO49_13600	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GKO49_13610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GKO49_13615	COG1610	YqeY-like protein
GKO49_13630	COG1295	ribonuclease BN
GKO49_13635	COG0358	DNA primase activity
GKO49_13645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GKO49_13650	COG0308	aminopeptidase N
GKO49_13665	COG3501	Rhs element vgr protein
GKO49_13695	COG0772	Belongs to the SEDS family
GKO49_13710	COG1792	Involved in formation and maintenance of cell shape
GKO49_13715	COG1077	Cell shape determining protein MreB Mrl
GKO49_13765	COG2199	diguanylate cyclase activity
GKO49_13770	COG0308	aminopeptidase N
GKO49_13800	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GKO49_13845	COG1505	serine-type exopeptidase activity
GKO49_13880	COG3275	phosphorelay sensor kinase activity
GKO49_13925	COG0659	secondary active sulfate transmembrane transporter activity
GKO49_13930	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GKO49_13930	COG5297	Belongs to the glycosyl hydrolase family 6
GKO49_13935	COG0840	transmembrane signaling receptor activity
GKO49_13990	COG3039	Transposase
GKO49_14010	COG0598	Magnesium transport protein CorA
GKO49_14020	COG1113	amino acid transport
GKO49_14025	COG5297	Belongs to the glycosyl hydrolase family 6
GKO49_14030	COG4305	rare lipoprotein A
GKO49_14035	COG0697	spore germination
GKO49_14090	COG4221	oxidoreductase activity
GKO49_14120	COG0456	acetyltransferase
GKO49_14130	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GKO49_14175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GKO49_14175	COG2111	Na H antiporter
GKO49_14180	COG1006	Multisubunit Na H antiporter MnhC subunit
GKO49_14185	COG0651	ATP synthesis coupled electron transport
GKO49_14195	COG2212	antiporter activity
GKO49_14200	COG1320	monovalent cation:proton antiporter activity
GKO49_14230	COG3104	oligopeptide transport
GKO49_14245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GKO49_14280	COG0183	Belongs to the thiolase family
GKO49_14330	COG2197	response regulator
GKO49_14390	COG0742	ribosomal rna small subunit methyltransferase
GKO49_14405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GKO49_14410	COG0405	Gamma-glutamyltransferase
GKO49_14470	COG1166	arginine decarboxylase activity
GKO49_14520	COG0606	chelatase, subunit chli
GKO49_14550	COG1649	PFAM Uncharacterised BCR, COG1649
GKO49_14550	COG0726	polysaccharide deacetylase
GKO49_14555	COG1215	transferase activity, transferring glycosyl groups
GKO49_14565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GKO49_14570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GKO49_14575	COG1609	Transcriptional regulator
GKO49_14600	COG3250	beta-galactosidase activity
GKO49_14650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GKO49_14655	COG4191	Histidine kinase
GKO49_14660	COG0784	Response regulator, receiver
GKO49_14665	COG4251	negative regulation of phosphorylation
GKO49_14670	COG2823	Periplasmic or secreted lipoprotein
GKO49_14675	COG0673	inositol 2-dehydrogenase activity
GKO49_14680	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GKO49_14715	COG1051	belongs to the nudix hydrolase family
GKO49_14715	COG1056	cytidyltransferase-related domain
GKO49_14750	COG1686	Belongs to the peptidase S11 family
GKO49_14755	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GKO49_14760	COG2951	lytic endotransglycosylase activity
GKO49_14845	COG3829	transcription factor binding
GKO49_14855	COG3039	Transposase
GKO49_14885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GKO49_14890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GKO49_14905	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_14930	COG1399	metal-binding, possibly nucleic acid-binding protein
GKO49_14975	COG1518	maintenance of DNA repeat elements
GKO49_14980	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GKO49_15020	COG2188	Transcriptional regulator
GKO49_15035	COG1450	Type ii and iii secretion system protein
GKO49_15050	COG3166	PFAM Fimbrial assembly family protein
GKO49_15055	COG3156	type II secretion system protein K
GKO49_15060	COG4795	General secretion pathway protein
GKO49_15065	COG2165	general secretion pathway protein
GKO49_15070	COG4970	Tfp pilus assembly protein FimT
GKO49_15075	COG2165	general secretion pathway protein
GKO49_15080	COG1459	type II secretion system
GKO49_15090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GKO49_15100	COG5295	Hep Hag repeat protein
GKO49_15105	COG0047	phosphoribosylformylglycinamidine synthase activity
GKO49_15105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GKO49_15110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GKO49_15115	COG4974	Belongs to the 'phage' integrase family
GKO49_15130	COG0795	lipopolysaccharide-transporting ATPase activity
GKO49_15155	COG0525	valine-tRNA ligase activity
GKO49_15185	COG3039	Transposase
GKO49_15335	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKO49_15355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GKO49_15360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GKO49_15360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GKO49_15365	COG0802	atpase or kinase
GKO49_15370	COG0860	N-Acetylmuramoyl-L-alanine amidase
GKO49_15395	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_15405	COG0501	Belongs to the peptidase M48B family
GKO49_15415	COG2081	HI0933 family
GKO49_15420	COG4681	YaeQ
GKO49_15435	COG0625	glutathione transferase activity
GKO49_15445	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GKO49_15455	COG0513	Belongs to the DEAD box helicase family
GKO49_15485	COG0483	inositol monophosphate 1-phosphatase activity
GKO49_15500	COG3300	MHYT domain
GKO49_15500	COG5001	Diguanylate cyclase
GKO49_15505	COG1509	lysine 2,3-aminomutase activity
GKO49_15520	COG0402	S-adenosylhomocysteine deaminase activity
GKO49_15550	COG1410	methionine synthase
GKO49_15550	COG0646	methionine synthase
GKO49_15555	COG0646	methionine synthase
GKO49_15555	COG1410	methionine synthase
GKO49_15565	COG1960	acyl-CoA dehydrogenase activity
GKO49_15590	COG0557	exoribonuclease II activity
GKO49_15605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKO49_15620	COG1555	photosystem II stabilization
GKO49_15625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GKO49_15680	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GKO49_15685	COG3177	Filamentation induced by cAMP protein fic
GKO49_15690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GKO49_15705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GKO49_15730	COG4191	Histidine kinase
GKO49_15735	COG0028	Belongs to the TPP enzyme family
GKO49_15755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GKO49_15785	COG5383	Protein conserved in bacteria
GKO49_15800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GKO49_15805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GKO49_15810	COG1473	amidohydrolase
GKO49_15825	COG3328	transposase activity
GKO49_16005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GKO49_16020	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GKO49_16100	COG1047	Peptidyl-prolyl cis-trans
GKO49_16105	COG0791	NLP P60 protein
GKO49_16110	COG0791	NLP P60 protein
GKO49_16125	COG1301	dicarboxylic acid transport
GKO49_16130	COG1785	Belongs to the alkaline phosphatase family
GKO49_16135	COG0037	tRNA processing
GKO49_16145	COG0142	geranyltranstransferase activity
GKO49_16165	COG0312	modulator of DNA gyrase
GKO49_16170	COG3028	Belongs to the UPF0307 family
GKO49_16175	COG0312	modulator of DNA gyrase
GKO49_16185	COG3164	Protein of unknown function
GKO49_16190	COG1530	ribonuclease E activity
GKO49_16200	COG2968	Membrane
GKO49_16205	COG3039	Transposase
GKO49_16260	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GKO49_16285	COG3118	belongs to the thioredoxin family
GKO49_16315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GKO49_16330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GKO49_16335	COG1393	Belongs to the ArsC family
GKO49_16340	COG0431	NADPH-dependent FMN reductase
GKO49_16345	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GKO49_16350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GKO49_16370	COG2205	protein histidine kinase activity
GKO49_16370	COG5002	protein histidine kinase activity
GKO49_16370	COG0784	Response regulator, receiver
GKO49_16415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKO49_16435	COG0842	Transport permease protein
GKO49_16440	COG1131	(ABC) transporter
GKO49_16470	COG1476	TRANSCRIPTIONal
GKO49_16480	COG4555	ABC transporter
GKO49_16515	COG0625	glutathione transferase activity
GKO49_16560	COG0583	DNA-binding transcription factor activity
GKO49_16600	COG1199	ATP-dependent helicase activity
GKO49_16615	COG1566	PFAM secretion protein HlyD family protein
GKO49_16635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GKO49_16645	COG0745	RESPONSE REGULATOR receiver
GKO49_16650	COG2205	protein histidine kinase activity
GKO49_16675	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GKO49_16675	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GKO49_16730	COG3237	CsbD-like
GKO49_16735	COG0180	Tryptophanyl-tRNA synthetase
GKO49_16740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKO49_16790	COG0753	catalase activity
GKO49_16795	COG1595	DNA-templated transcription, initiation
GKO49_16805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GKO49_16815	COG0628	permease
GKO49_16830	COG1040	competence protein
GKO49_16850	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_16865	COG0463	Glycosyl transferase, family 2
GKO49_16875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GKO49_16880	COG3100	YcgL domain-containing protein
GKO49_16900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GKO49_16915	COG2239	Acts as a magnesium transporter
GKO49_16925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GKO49_16925	COG1042	CoA-binding domain protein
GKO49_16925	COG0045	succinate-CoA ligase (ADP-forming) activity
GKO49_16935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GKO49_16940	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GKO49_16980	COG3485	protocatechuate 3,4-dioxygenase
GKO49_16985	COG3485	protocatechuate 3,4-dioxygenase
GKO49_17000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GKO49_17005	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GKO49_17030	COG4221	oxidoreductase activity
GKO49_17045	COG0018	arginyl-trna synthetase
GKO49_17050	COG2003	Belongs to the UPF0758 family
GKO49_17055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GKO49_17080	COG0463	Glycosyl transferase, family 2
GKO49_17095	COG1475	DNA binding
GKO49_17100	COG1192	Involved in chromosome partitioning
GKO49_17115	COG0708	Exodeoxyribonuclease III
GKO49_17120	COG2211	Major facilitator Superfamily
GKO49_17135	COG0739	heme binding
GKO49_17220	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GKO49_17235	COG2814	Major facilitator Superfamily
GKO49_17250	COG1289	transmembrane transporter activity
GKO49_17265	COG1136	(ABC) transporter
GKO49_17265	COG0577	efflux transmembrane transporter activity
GKO49_17270	COG0151	Belongs to the GarS family
GKO49_17280	COG0419	ATPase involved in DNA repair
GKO49_17295	COG2267	carboxylic ester hydrolase activity
GKO49_17300	COG2267	carboxylic ester hydrolase activity
GKO49_17305	COG2267	carboxylic ester hydrolase activity
GKO49_17325	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GKO49_17370	COG0439	Biotin carboxylase
GKO49_17380	COG0511	ligase activity, forming carbon-carbon bonds
GKO49_17395	COG1324	tolerance protein
GKO49_17430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GKO49_17450	COG0534	Mate efflux family protein
GKO49_17455	COG0616	signal peptide processing
GKO49_17465	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_17485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GKO49_17485	COG1754	DNA topoisomerase type I activity
GKO49_17505	COG0758	DNA mediated transformation
GKO49_17510	COG1652	LysM domain
GKO49_17515	COG0242	peptide deformylase activity
GKO49_17525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GKO49_17525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GKO49_17575	COG1560	Kdo2-lipid A biosynthetic process
GKO49_17585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GKO49_17705	COG0735	belongs to the Fur family
GKO49_17765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GKO49_17770	COG0084	hydrolase, TatD family'
GKO49_17785	COG1960	acyl-CoA dehydrogenase activity
GKO49_17800	COG0367	asparagine synthase
GKO49_17810	COG0305	Participates in initiation and elongation during chromosome replication
GKO49_17815	COG0415	Belongs to the DNA photolyase family
GKO49_17830	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_17930	COG5001	Diguanylate cyclase
GKO49_17930	COG5002	protein histidine kinase activity
GKO49_17935	COG1187	pseudouridine synthase activity
GKO49_17965	COG0475	glutathione-regulated potassium exporter activity
GKO49_17970	COG5000	phosphorelay sensor kinase activity
GKO49_17970	COG5002	protein histidine kinase activity
GKO49_18020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GKO49_18070	COG0531	amino acid
GKO49_18075	COG0531	amino acid
GKO49_18085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GKO49_18090	COG0277	FAD linked oxidase domain protein
GKO49_18140	COG0583	DNA-binding transcription factor activity
GKO49_18150	COG3039	Transposase
GKO49_18175	COG1451	nucleotide metabolic process
GKO49_18195	COG0183	Belongs to the thiolase family
GKO49_18210	COG0745	RESPONSE REGULATOR receiver
GKO49_18210	COG3706	GGDEF domain
GKO49_18225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GKO49_18225	COG1793	dna ligase
GKO49_18235	COG1793	dna ligase
GKO49_18240	COG1201	RNA secondary structure unwinding
GKO49_18260	COG1278	Cold shock
GKO49_18265	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GKO49_18280	COG3046	protein related to deoxyribodipyrimidine photolyase
GKO49_18285	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
GKO49_18290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GKO49_18350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GKO49_18365	COG1250	3-hydroxyacyl-CoA dehydrogenase
GKO49_18365	COG1024	Enoyl-CoA hydratase
GKO49_18385	COG1024	Enoyl-CoA hydratase
GKO49_18390	COG1960	acyl-CoA dehydrogenase activity
GKO49_18460	COG2353	YceI-like domain
GKO49_18470	COG2353	YceI-like domain
GKO49_18485	COG1760	l-serine dehydratase
GKO49_18495	COG0626	cystathionine gamma-synthase activity
GKO49_18500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GKO49_18505	COG0739	heme binding
GKO49_18510	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GKO49_18515	COG1272	protein, Hemolysin III
GKO49_18535	COG0463	Glycosyl transferase, family 2
GKO49_18545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GKO49_18555	COG4771	TonB-dependent receptor
GKO49_18560	COG1309	transcriptional regulator
GKO49_18570	COG1960	acyl-CoA dehydrogenase activity
GKO49_18615	COG0330	HflC and HflK could
GKO49_18630	COG3956	TIGRFAM MazG family protein
GKO49_18640	COG0494	nUDIX hydrolase
GKO49_18650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GKO49_18655	COG0837	glucose binding
GKO49_18670	COG3858	chitin binding
GKO49_18670	COG1388	LysM domain
GKO49_18690	COG1472	Belongs to the glycosyl hydrolase 3 family
GKO49_18745	COG3537	Alpha-1,2-mannosidase
GKO49_18790	COG3142	Participates in the control of copper homeostasis
GKO49_18795	COG1446	asparaginase
GKO49_18835	COG0631	protein serine/threonine phosphatase activity
GKO49_18845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GKO49_18870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GKO49_18905	COG0740	serine-type endopeptidase activity
GKO49_18910	COG0544	peptidyl-prolyl cis-trans isomerase activity
GKO49_18985	COG4783	chaperone-mediated protein folding
GKO49_19010	COG0438	transferase activity, transferring glycosyl groups
GKO49_19015	COG0671	phosphoesterase, PA-phosphatase related
GKO49_19040	COG2833	Protein of unknown function (DUF455)
GKO49_19060	COG0285	dihydrofolate synthase activity
GKO49_19070	COG0588	phosphoglycerate mutase activity
GKO49_19100	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GKO49_19105	COG4208	sulfate ABC transporter
GKO49_19110	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GKO49_19115	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GKO49_19120	COG0156	8-amino-7-oxononanoate synthase activity
GKO49_19150	COG0446	pyridine nucleotide-disulphide oxidoreductase
GKO49_19150	COG1902	pentaerythritol trinitrate reductase activity
GKO49_19180	COG0584	glycerophosphoryl diester phosphodiesterase
GKO49_19230	COG1278	Cold shock
GKO49_19235	COG0412	Dienelactone hydrolase
GKO49_19260	COG0489	protein tyrosine kinase activity
GKO49_19345	COG0489	protein tyrosine kinase activity
GKO49_19370	COG0412	Dienelactone hydrolase
GKO49_19380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GKO49_19430	COG2890	protein-(glutamine-N5) methyltransferase activity
GKO49_19440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GKO49_19445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GKO49_19480	COG0133	tryptophan synthase activity
GKO49_19490	COG0159	tryptophan synthase activity
GKO49_19545	COG1028	Short-chain dehydrogenase reductase Sdr
GKO49_19565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKO49_19585	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GKO49_19590	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GKO49_19595	COG1034	ATP synthesis coupled electron transport
GKO49_19600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GKO49_19615	COG0713	ATP synthesis coupled electron transport
GKO49_19645	COG0195	Participates in both transcription termination and antitermination
GKO49_19665	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GKO49_19700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GKO49_19705	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GKO49_19715	COG2095	MarC family integral membrane protein
GKO49_19735	COG1611	Belongs to the LOG family
GKO49_19775	COG4969	Belongs to the N-Me-Phe pilin family
GKO49_19780	COG0556	nucleotide-excision repair
GKO49_19820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GKO49_19825	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GKO49_19830	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GKO49_19835	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GKO49_19845	COG0776	regulation of translation
GKO49_19890	COG0438	transferase activity, transferring glycosyl groups
GKO49_19895	COG0438	transferase activity, transferring glycosyl groups
GKO49_19950	COG3040	lipid binding
GKO49_20010	COG0067	glutamate synthase
GKO49_20010	COG0069	glutamate synthase activity
GKO49_20010	COG0070	glutamate synthase
GKO49_20015	COG0493	'glutamate synthase
GKO49_20035	COG0840	transmembrane signaling receptor activity
GKO49_20045	COG0840	transmembrane signaling receptor activity
GKO49_20060	COG3039	Transposase
GKO49_20070	COG2205	protein histidine kinase activity
GKO49_20075	COG0745	RESPONSE REGULATOR receiver
GKO49_20130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GKO49_20135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GKO49_20180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GKO49_20255	COG4771	TonB-dependent receptor
GKO49_20265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GKO49_20285	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GKO49_20290	COG1360	Flagellar Motor Protein
GKO49_20295	COG1192	Involved in chromosome partitioning
GKO49_20300	COG0835	chemotaxis
GKO49_20310	COG0745	RESPONSE REGULATOR receiver
GKO49_20330	COG0840	transmembrane signaling receptor activity
GKO49_20350	COG0840	transmembrane signaling receptor activity
GKO49_20360	COG0840	transmembrane signaling receptor activity
GKO49_20365	COG0840	transmembrane signaling receptor activity
GKO49_20370	COG0840	transmembrane signaling receptor activity
GKO49_20375	COG0840	transmembrane signaling receptor activity
GKO49_20390	COG0835	chemotaxis
GKO49_20445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GKO49_20475	COG0318	PFAM AMP-dependent synthetase and ligase
GKO49_20480	COG1024	Enoyl-CoA hydratase
GKO49_20485	COG2205	protein histidine kinase activity
GKO49_20485	COG0784	Response regulator, receiver
GKO49_20485	COG2198	Histidine kinase
GKO49_20535	COG3501	Rhs element vgr protein
GKO49_20560	COG1127	ABC transporter
GKO49_20565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GKO49_20570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GKO49_20585	COG2853	Lipoprotein
GKO49_20605	COG2895	sulfate adenylyltransferase (ATP) activity
GKO49_20605	COG0529	Catalyzes the synthesis of activated sulfate
GKO49_20620	COG3293	Transposase
GKO49_20625	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GKO49_20660	COG2969	positive regulation of protein catabolic process
GKO49_20665	COG0625	glutathione transferase activity
GKO49_20670	COG2857	Cytochrome c1
GKO49_20675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GKO49_20680	COG0723	plastoquinol--plastocyanin reductase activity
GKO49_20685	COG0741	lytic transglycosylase activity
GKO49_20705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GKO49_20710	COG1702	phosphate starvation-inducible protein PhoH
GKO49_20730	COG4535	Mg2 and Co2 transporter CorC
GKO49_20745	COG1012	belongs to the aldehyde dehydrogenase family
GKO49_20755	COG1177	transmembrane transport
GKO49_20765	COG3842	ATPase activity
GKO49_20800	COG0174	glutamine synthetase
GKO49_20810	COG0745	RESPONSE REGULATOR receiver
GKO49_20810	COG3706	GGDEF domain
GKO49_20815	COG0477	Major facilitator Superfamily
GKO49_20825	COG0243	molybdopterin cofactor binding
GKO49_20855	COG3039	Transposase
GKO49_20870	COG2733	membrane
GKO49_20875	COG5002	protein histidine kinase activity
GKO49_20875	COG2205	protein histidine kinase activity
GKO49_20875	COG0784	Response regulator, receiver
GKO49_20885	COG3039	Transposase
GKO49_20890	COG2902	Dehydrogenase
GKO49_20900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GKO49_20905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GKO49_20925	COG1609	Transcriptional regulator
GKO49_20930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GKO49_20930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKO49_20935	COG1105	Belongs to the carbohydrate kinase PfkB family
GKO49_20940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GKO49_20940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GKO49_20955	COG3039	Transposase
GKO49_20975	COG3039	Transposase
GKO49_21075	COG0824	Thioesterase
GKO49_21085	COG0848	biopolymer transport protein
GKO49_21100	COG2885	chlorophyll binding
GKO49_21110	COG0602	queuosine metabolic process
GKO49_21160	COG0514	ATP-dependent DNA helicase (RecQ)
GKO49_21165	COG0783	Belongs to the Dps family
GKO49_21170	COG1643	Atp-dependent helicase
GKO49_21205	COG0535	radical SAM domain protein
GKO49_21210	COG0535	radical SAM domain protein
GKO49_21215	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GKO49_21230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GKO49_21245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GKO49_21255	COG1199	ATP-dependent helicase activity
GKO49_21265	COG1397	ADP-ribosylglycohydrolase
GKO49_21275	COG0189	ligase activity
GKO49_21295	COG0840	transmembrane signaling receptor activity
GKO49_21345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GKO49_21355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GKO49_21360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GKO49_21370	COG0505	Belongs to the CarA family
GKO49_21375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GKO49_21385	COG2258	MOSC domain
GKO49_21390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GKO49_21460	COG0477	Major facilitator Superfamily
GKO49_21470	COG1070	Carbohydrate kinase
GKO49_21485	COG3209	COG3209 Rhs family protein
GKO49_21525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GKO49_21530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GKO49_21580	COG0339	signal peptide processing
GKO49_21620	COG1956	GAF domain-containing protein
GKO49_21635	COG0720	synthase
GKO49_21640	COG0513	Belongs to the DEAD box helicase family
GKO49_21655	COG0625	glutathione transferase activity
GKO49_21685	COG0626	cystathionine gamma-synthase activity
GKO49_21730	COG3328	transposase activity
GKO49_21755	COG2086	electron transfer activity
GKO49_21780	COG0662	Cupin 2, conserved barrel domain protein
GKO49_21780	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GKO49_21785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GKO49_21820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GKO49_21820	COG3218	ABC-type transport auxiliary lipoprotein component
GKO49_21825	COG1127	ABC transporter
GKO49_21830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GKO49_21855	COG1183	phosphatidylcholine synthase activity
GKO49_21885	COG3039	Transposase
GKO49_21905	COG1136	(ABC) transporter
GKO49_21950	COG0596	Alpha beta hydrolase
GKO49_21960	COG0318	PFAM AMP-dependent synthetase and ligase
GKO49_21965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKO49_21995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GKO49_22110	COG3501	Rhs element vgr protein
GKO49_22170	COG0732	type I restriction modification DNA specificity domain
GKO49_22185	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GKO49_22230	COG0732	type I restriction modification DNA specificity domain
GKO49_22265	COG0406	alpha-ribazole phosphatase activity
GKO49_22265	COG0328	RNA-DNA hybrid ribonuclease activity
GKO49_22305	COG0587	DNA-directed DNA polymerase activity
GKO49_22320	COG1297	OPT oligopeptide transporter protein
GKO49_22345	COG1506	peptidase
GKO49_22345	COG0823	Involved in the tonB-independent uptake of proteins
GKO49_22365	COG1917	Cupin 2, conserved barrel domain protein
GKO49_22365	COG2207	Transcriptional regulator
GKO49_22390	COG0753	catalase activity
GKO49_22420	COG0126	phosphoglycerate kinase activity
GKO49_22430	COG0469	pyruvate kinase activity
GKO49_22435	COG3588	fructose-bisphosphate aldolase
GKO49_22440	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GKO49_22485	COG2198	Histidine kinase
GKO49_22485	COG2205	protein histidine kinase activity
GKO49_22485	COG0784	Response regulator, receiver
GKO49_22515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GKO49_22525	COG2895	sulfate adenylyltransferase (ATP) activity
GKO49_22525	COG0529	Catalyzes the synthesis of activated sulfate