locus-tag	class	description
IXO134_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO134_000020	COG0187	DNA topoisomerase II activity
IXO134_000030	COG0501	Belongs to the peptidase M48B family
IXO134_000060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO134_000070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO134_000080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO134_000090	COG4772	TonB-dependent receptor
IXO134_000105	COG3039	Transposase
IXO134_000110	COG1304	FMN binding
IXO134_000130	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO134_000140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO134_000215	COG3039	Transposase
IXO134_000230	COG2826	transposase and inactivated derivatives, IS30 family
IXO134_000255	COG3039	Transposase
IXO134_000265	COG1090	epimerase
IXO134_000275	COG0642	Histidine kinase
IXO134_000285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO134_000390	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO134_000465	COG3264	Mechanosensitive ion channel
IXO134_000465	COG1511	domain protein
IXO134_000480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO134_000485	COG2354	Protein conserved in bacteria
IXO134_000490	COG1649	PFAM Uncharacterised BCR, COG1649
IXO134_000510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO134_000535	COG0702	epimerase
IXO134_000550	COG1858	cytochrome C peroxidase
IXO134_000625	COG0513	Belongs to the DEAD box helicase family
IXO134_000630	COG3039	Transposase
IXO134_000680	COG1131	(ABC) transporter
IXO134_000710	COG1136	(ABC) transporter
IXO134_000755	COG1272	protein, Hemolysin III
IXO134_000760	COG1111	helicase
IXO134_000760	COG1205	dead DEAH box helicase
IXO134_000820	COG0067	glutamate synthase
IXO134_000820	COG0069	glutamate synthase activity
IXO134_000820	COG0070	glutamate synthase
IXO134_000825	COG0493	'glutamate synthase
IXO134_000865	COG1609	Transcriptional regulator
IXO134_000895	COG0366	Alpha amylase catalytic
IXO134_000900	COG0366	Alpha amylase catalytic
IXO134_000945	COG0606	chelatase, subunit chli
IXO134_000985	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO134_000990	COG1166	arginine decarboxylase activity
IXO134_001055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO134_001080	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_001105	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO134_001125	COG0210	DNA helicase
IXO134_001140	COG3132	Protein of unknown function, DUF480
IXO134_001145	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO134_001150	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO134_001185	COG2937	Belongs to the GPAT DAPAT family
IXO134_001215	COG2755	lipolytic protein G-D-S-L family
IXO134_001230	COG3186	Phenylalanine-4-hydroxylase
IXO134_001235	COG1522	sequence-specific DNA binding
IXO134_001280	COG1064	alcohol dehydrogenase
IXO134_001285	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO134_001295	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO134_001305	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO134_001325	COG0676	glucose-6-phosphate 1-epimerase activity
IXO134_001390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO134_001415	COG2853	Lipoprotein
IXO134_001430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO134_001435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO134_001440	COG1127	ABC transporter
IXO134_001515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO134_001525	COG3039	Transposase
IXO134_001530	COG3265	gluconokinase activity
IXO134_001535	COG2211	Major facilitator Superfamily
IXO134_001540	COG3459	Glycosyltransferase 36 associated
IXO134_001550	COG2205	protein histidine kinase activity
IXO134_001560	COG1414	Transcriptional regulator
IXO134_001565	COG0738	Major facilitator superfamily
IXO134_001570	COG3254	rhamnose metabolic process
IXO134_001600	COG0339	signal peptide processing
IXO134_001630	COG0564	pseudouridine synthase activity
IXO134_001640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO134_001650	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO134_001720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO134_001730	COG0842	Transport permease protein
IXO134_001735	COG1131	(ABC) transporter
IXO134_001760	COG1476	TRANSCRIPTIONal
IXO134_001770	COG4555	ABC transporter
IXO134_001810	COG0625	glutathione transferase activity
IXO134_001855	COG0583	DNA-binding transcription factor activity
IXO134_001895	COG1199	ATP-dependent helicase activity
IXO134_001915	COG1566	PFAM secretion protein HlyD family protein
IXO134_001935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO134_001975	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO134_001975	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO134_001980	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO134_001995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO134_002030	COG3237	CsbD-like
IXO134_002035	COG0180	Tryptophanyl-tRNA synthetase
IXO134_002040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO134_002085	COG0753	catalase activity
IXO134_002100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO134_002110	COG0628	permease
IXO134_002120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO134_002125	COG1040	competence protein
IXO134_002130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO134_002135	COG0156	8-amino-7-oxononanoate synthase activity
IXO134_002145	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_002160	COG0463	Glycosyl transferase, family 2
IXO134_002170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO134_002175	COG3100	YcgL domain-containing protein
IXO134_002195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO134_002210	COG2239	Acts as a magnesium transporter
IXO134_002225	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO134_002225	COG1042	CoA-binding domain protein
IXO134_002225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO134_002235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO134_002240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO134_002275	COG3485	protocatechuate 3,4-dioxygenase
IXO134_002295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO134_002300	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO134_002325	COG4221	oxidoreductase activity
IXO134_002350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO134_002375	COG0463	Glycosyl transferase, family 2
IXO134_002390	COG1475	DNA binding
IXO134_002395	COG1192	Involved in chromosome partitioning
IXO134_002410	COG0708	Exodeoxyribonuclease III
IXO134_002415	COG2211	Major facilitator Superfamily
IXO134_002430	COG0739	heme binding
IXO134_002475	COG0745	RESPONSE REGULATOR receiver
IXO134_002515	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO134_002530	COG2814	Major facilitator Superfamily
IXO134_002545	COG1289	transmembrane transporter activity
IXO134_002570	COG0151	Belongs to the GarS family
IXO134_002580	COG0138	bifunctional purine biosynthesis protein purh
IXO134_002590	COG2267	carboxylic ester hydrolase activity
IXO134_002595	COG2267	carboxylic ester hydrolase activity
IXO134_002600	COG2267	carboxylic ester hydrolase activity
IXO134_002620	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO134_002665	COG0439	Biotin carboxylase
IXO134_002675	COG0511	ligase activity, forming carbon-carbon bonds
IXO134_002680	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO134_002690	COG1324	tolerance protein
IXO134_002725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO134_002750	COG0534	Mate efflux family protein
IXO134_002755	COG0616	signal peptide processing
IXO134_002765	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_002780	COG0009	L-threonylcarbamoyladenylate synthase
IXO134_002785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO134_002785	COG1754	DNA topoisomerase type I activity
IXO134_002800	COG2922	Belongs to the Smg family
IXO134_002805	COG0758	DNA mediated transformation
IXO134_002810	COG1652	LysM domain
IXO134_002815	COG0242	peptide deformylase activity
IXO134_002820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO134_002825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO134_002825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO134_002875	COG1560	Kdo2-lipid A biosynthetic process
IXO134_002885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO134_003030	COG3039	Transposase
IXO134_003040	COG1271	oxidase subunit
IXO134_003095	COG2972	Histidine kinase
IXO134_003110	COG0531	amino acid
IXO134_003130	COG3590	peptidase
IXO134_003140	COG0667	Aldo Keto reductase
IXO134_003155	COG3384	dioxygenase
IXO134_003165	COG1573	uracil-dna glycosylase
IXO134_003175	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO134_003185	COG0025	NhaP-type Na H and K H
IXO134_003190	COG1131	(ABC) transporter
IXO134_003195	COG0842	Transport permease protein
IXO134_003210	COG1404	Belongs to the peptidase S8 family
IXO134_003225	COG0745	RESPONSE REGULATOR receiver
IXO134_003275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO134_003300	COG2202	Pas domain
IXO134_003300	COG2205	protein histidine kinase activity
IXO134_003330	COG2813	Specifically methylates the guanine in position
IXO134_003335	COG1187	pseudouridine synthase activity
IXO134_003340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO134_003380	COG0697	spore germination
IXO134_003390	COG2011	ABC-type metal ion transport system permease component
IXO134_003420	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO134_003430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO134_003450	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO134_003460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO134_003470	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO134_003475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO134_003480	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO134_003485	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXO134_003535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO134_003540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO134_003590	COG0339	signal peptide processing
IXO134_003630	COG1956	GAF domain-containing protein
IXO134_003635	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO134_003645	COG0720	synthase
IXO134_003650	COG0513	Belongs to the DEAD box helicase family
IXO134_003665	COG0625	glutathione transferase activity
IXO134_003695	COG0626	cystathionine gamma-synthase activity
IXO134_003735	COG3328	transposase activity
IXO134_003760	COG2086	electron transfer activity
IXO134_003785	COG0662	Cupin 2, conserved barrel domain protein
IXO134_003785	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO134_003790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO134_003825	COG3218	ABC-type transport auxiliary lipoprotein component
IXO134_003825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO134_003830	COG1127	ABC transporter
IXO134_003835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO134_003855	COG0442	prolyl-tRNA aminoacylation
IXO134_003865	COG1183	phosphatidylcholine synthase activity
IXO134_003895	COG3039	Transposase
IXO134_003930	COG3039	Transposase
IXO134_003960	COG0525	valine-tRNA ligase activity
IXO134_003975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO134_003985	COG0795	lipopolysaccharide-transporting ATPase activity
IXO134_004000	COG4974	Belongs to the 'phage' integrase family
IXO134_004005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO134_004010	COG0047	phosphoribosylformylglycinamidine synthase activity
IXO134_004010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXO134_004015	COG5295	Hep Hag repeat protein
IXO134_004025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO134_004035	COG1459	type II secretion system
IXO134_004040	COG2165	general secretion pathway protein
IXO134_004045	COG4970	Tfp pilus assembly protein FimT
IXO134_004050	COG2165	general secretion pathway protein
IXO134_004055	COG4795	General secretion pathway protein
IXO134_004060	COG3156	type II secretion system protein K
IXO134_004065	COG3166	PFAM Fimbrial assembly family protein
IXO134_004080	COG1450	Type ii and iii secretion system protein
IXO134_004095	COG2188	Transcriptional regulator
IXO134_004140	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO134_004145	COG1518	maintenance of DNA repeat elements
IXO134_004180	COG3039	Transposase
IXO134_004200	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO134_004225	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_004230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO134_004240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO134_004245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO134_004280	COG3829	transcription factor binding
IXO134_004360	COG2826	transposase and inactivated derivatives, IS30 family
IXO134_004370	COG0678	peroxiredoxin activity
IXO134_004390	COG0330	HflC and HflK could
IXO134_004395	COG0330	HflC and HflK could
IXO134_004405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO134_004410	COG0308	aminopeptidase N
IXO134_004470	COG1560	Kdo2-lipid A biosynthetic process
IXO134_004475	COG1519	Transferase
IXO134_004480	COG1538	Outer membrane efflux protein
IXO134_004485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO134_004515	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO134_004520	COG0066	3-isopropylmalate dehydratase activity
IXO134_004525	COG2226	methyltransferase
IXO134_004555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO134_004565	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO134_004570	COG3710	Transcriptional regulator
IXO134_004595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO134_004615	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO134_004650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO134_004660	COG3781	membrane
IXO134_004800	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO134_004820	COG1217	gtp-binding protein TYPA
IXO134_004825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO134_004830	COG0039	L-malate dehydrogenase activity
IXO134_004835	COG0625	glutathione transferase activity
IXO134_004850	COG3039	Transposase
IXO134_004875	COG0584	glycerophosphoryl diester phosphodiesterase
IXO134_004910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO134_004945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO134_004950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO134_004955	COG0583	DNA-binding transcription factor activity
IXO134_004960	COG3634	alkyl hydroperoxide reductase activity
IXO134_004970	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO134_005010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO134_005010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO134_005025	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO134_005050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO134_005075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO134_005085	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO134_005115	COG1295	ribonuclease BN
IXO134_005120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO134_005140	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO134_005150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO134_005155	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO134_005165	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO134_005180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO134_005190	COG0193	aminoacyl-tRNA hydrolase activity
IXO134_005195	COG0012	GTP binding
IXO134_005225	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO134_005230	COG0250	Participates in transcription elongation, termination and antitermination
IXO134_005235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO134_005245	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO134_005250	COG0222	ribosome binding
IXO134_005255	COG0085	RNA polymerase activity
IXO134_005260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO134_005265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO134_005270	COG0049	tRNA binding
IXO134_005290	COG0051	transcription antitermination factor activity, RNA binding
IXO134_005295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO134_005300	COG0088	Forms part of the polypeptide exit tunnel
IXO134_005305	COG0089	rRNA binding
IXO134_005320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO134_005330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO134_005335	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO134_005340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO134_005345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO134_005355	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO134_005385	COG1841	ribosomal large subunit assembly
IXO134_005395	COG0201	protein transport
IXO134_005405	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO134_005410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO134_005420	COG0203	ribosomal protein L17
IXO134_005480	COG3551	Protein conserved in bacteria
IXO134_005510	COG2194	sulfuric ester hydrolase activity
IXO134_005520	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO134_005525	COG0745	RESPONSE REGULATOR receiver
IXO134_005530	COG0642	Histidine kinase
IXO134_005540	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO134_005545	COG2894	cell division
IXO134_005560	COG4585	Histidine kinase
IXO134_005565	COG2197	response regulator
IXO134_005580	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO134_005605	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IXO134_005610	COG2963	transposase activity
IXO134_005715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO134_005725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO134_005735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO134_005780	COG3328	transposase activity
IXO134_005795	COG3179	chitinase
IXO134_005910	COG3039	Transposase
IXO134_005925	COG3039	Transposase
IXO134_005985	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO134_006005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO134_006010	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO134_006015	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO134_006030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO134_006100	COG0587	DNA-directed DNA polymerase activity
IXO134_006115	COG1297	OPT oligopeptide transporter protein
IXO134_006135	COG1506	peptidase
IXO134_006135	COG0823	Involved in the tonB-independent uptake of proteins
IXO134_006155	COG2207	Transcriptional regulator
IXO134_006155	COG1917	Cupin 2, conserved barrel domain protein
IXO134_006180	COG0753	catalase activity
IXO134_006220	COG0469	pyruvate kinase activity
IXO134_006225	COG3588	fructose-bisphosphate aldolase
IXO134_006230	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO134_006280	COG0784	Response regulator, receiver
IXO134_006280	COG2198	Histidine kinase
IXO134_006280	COG2205	protein histidine kinase activity
IXO134_006300	COG0175	sulfate reduction
IXO134_006305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO134_006310	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO134_006315	COG0175	sulfate reduction
IXO134_006320	COG2895	sulfate adenylyltransferase (ATP) activity
IXO134_006320	COG0529	Catalyzes the synthesis of activated sulfate
IXO134_006330	COG3039	Transposase
IXO134_006340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO134_006345	COG0308	aminopeptidase N
IXO134_006365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO134_006385	COG1970	mechanosensitive ion channel activity
IXO134_006415	COG0471	metal ion transport
IXO134_006415	COG3273	potassium ion transport
IXO134_006425	COG2022	thiamine diphosphate biosynthetic process
IXO134_006545	COG3118	belongs to the thioredoxin family
IXO134_006570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO134_006595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO134_006625	COG2968	Membrane
IXO134_006640	COG3164	Protein of unknown function
IXO134_006650	COG0312	modulator of DNA gyrase
IXO134_006655	COG3028	Belongs to the UPF0307 family
IXO134_006660	COG0312	modulator of DNA gyrase
IXO134_006685	COG0142	geranyltranstransferase activity
IXO134_006690	COG1722	exodeoxyribonuclease VII activity
IXO134_006695	COG0037	tRNA processing
IXO134_006700	COG1785	Belongs to the alkaline phosphatase family
IXO134_006705	COG1301	dicarboxylic acid transport
IXO134_006725	COG0791	NLP P60 protein
IXO134_006730	COG0791	NLP P60 protein
IXO134_006735	COG1047	Peptidyl-prolyl cis-trans
IXO134_006740	COG2311	Membrane
IXO134_006745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO134_006785	COG0489	protein tyrosine kinase activity
IXO134_006790	COG0717	Belongs to the dCTP deaminase family
IXO134_006810	COG0412	Dienelactone hydrolase
IXO134_006820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO134_006865	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO134_006870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO134_006875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO134_006880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO134_006900	COG0101	tRNA pseudouridine synthase activity
IXO134_006905	COG0135	phosphoribosylanthranilate isomerase activity
IXO134_006925	COG0159	tryptophan synthase activity
IXO134_006930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO134_006935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO134_006985	COG0149	triose-phosphate isomerase activity
IXO134_007000	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO134_007010	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO134_007015	COG0649	NAD binding
IXO134_007020	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO134_007025	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO134_007030	COG1034	ATP synthesis coupled electron transport
IXO134_007035	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO134_007065	COG1007	ATP synthesis coupled electron transport
IXO134_007075	COG0779	Required for maturation of 30S ribosomal subunits
IXO134_007080	COG0195	Participates in both transcription termination and antitermination
IXO134_007085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IXO134_007100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO134_007105	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO134_007140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO134_007150	COG2095	MarC family integral membrane protein
IXO134_007165	COG1611	Belongs to the LOG family
IXO134_007200	COG3039	Transposase
IXO134_007365	COG3179	chitinase
IXO134_007410	COG4695	Portal protein
IXO134_007430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IXO134_007430	COG0758	DNA mediated transformation
IXO134_007460	COG4969	Belongs to the N-Me-Phe pilin family
IXO134_007465	COG0556	nucleotide-excision repair
IXO134_007505	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO134_007520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO134_007575	COG0438	transferase activity, transferring glycosyl groups
IXO134_007580	COG0438	transferase activity, transferring glycosyl groups
IXO134_007590	COG0438	transferase activity, transferring glycosyl groups
IXO134_007635	COG3040	lipid binding
IXO134_007720	COG0784	Response regulator, receiver
IXO134_007720	COG4191	Histidine kinase
IXO134_007740	COG0552	protein localization to endoplasmic reticulum
IXO134_007750	COG3938	Belongs to the proline racemase family
IXO134_007755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO134_007770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO134_007780	COG0006	proline dipeptidase activity
IXO134_007795	COG0531	amino acid
IXO134_007845	COG4206	TonB-dependent receptor
IXO134_007870	COG3328	transposase activity
IXO134_007930	COG0746	molybdenum cofactor guanylyltransferase activity
IXO134_007955	COG1648	precorrin-2 dehydrogenase activity
IXO134_007955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO134_007990	COG3039	Transposase
IXO134_007995	COG3039	Transposase
IXO134_008025	COG3039	Transposase
IXO134_008040	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO134_008060	COG1054	Belongs to the UPF0176 family
IXO134_008075	COG1530	ribonuclease E activity
IXO134_008085	COG3064	Membrane
IXO134_008090	COG0428	transporter
IXO134_008095	COG0428	transporter
IXO134_008105	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO134_008155	COG3039	Transposase
IXO134_008285	COG0631	protein serine/threonine phosphatase activity
IXO134_008290	COG0515	serine threonine protein kinase
IXO134_008320	COG1858	cytochrome C peroxidase
IXO134_008375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO134_008380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO134_008400	COG2201	protein-glutamate methylesterase activity
IXO134_008445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO134_008465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO134_008480	COG1595	DNA-templated transcription, initiation
IXO134_008530	COG2244	polysaccharide biosynthetic process
IXO134_008560	COG2264	protein methyltransferase activity
IXO134_008570	COG0438	transferase activity, transferring glycosyl groups
IXO134_008585	COG1136	(ABC) transporter
IXO134_008590	COG1132	(ABC) transporter
IXO134_008600	COG0477	Major facilitator Superfamily
IXO134_008610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO134_008625	COG1253	flavin adenine dinucleotide binding
IXO134_008635	COG0306	phosphate transporter
IXO134_008665	COG0504	CTP synthase activity
IXO134_008670	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO134_008680	COG0148	phosphopyruvate hydratase activity
IXO134_008685	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO134_008690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO134_008700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO134_008710	COG2840	Smr protein MutS2
IXO134_008715	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO134_008720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO134_008725	COG1238	metal cluster binding
IXO134_008740	COG1534	Rna-binding protein
IXO134_008745	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO134_008755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO134_008770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO134_008775	COG1546	Belongs to the CinA family
IXO134_008790	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO134_008795	COG2137	regulation of response to DNA damage stimulus
IXO134_008800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO134_008805	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO134_008830	COG0305	Participates in initiation and elongation during chromosome replication
IXO134_008835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO134_008860	COG1741	Belongs to the pirin family
IXO134_008865	COG0583	DNA-binding transcription factor activity
IXO134_008895	COG0351	phosphomethylpyrimidine kinase
IXO134_008905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO134_008910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO134_008930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO134_008940	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO134_008945	COG3734	2-keto-3-deoxy-galactonokinase
IXO134_008955	COG4948	Mandelate Racemase Muconate Lactonizing
IXO134_008960	COG0800	Aldolase
IXO134_008975	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO134_008985	COG1070	Carbohydrate kinase
IXO134_008995	COG0477	Major facilitator Superfamily
IXO134_009015	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO134_009065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO134_009070	COG2258	MOSC domain
IXO134_009080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO134_009085	COG0505	Belongs to the CarA family
IXO134_009095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO134_009100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO134_009110	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO134_009180	COG2205	protein histidine kinase activity
IXO134_009180	COG2198	Histidine kinase
IXO134_009180	COG0784	Response regulator, receiver
IXO134_009185	COG1024	Enoyl-CoA hydratase
IXO134_009190	COG0318	PFAM AMP-dependent synthetase and ligase
IXO134_009220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO134_009250	COG0840	transmembrane signaling receptor activity
IXO134_009270	COG3039	Transposase
IXO134_009285	COG0835	chemotaxis
IXO134_009300	COG0840	transmembrane signaling receptor activity
IXO134_009305	COG0840	transmembrane signaling receptor activity
IXO134_009310	COG0840	transmembrane signaling receptor activity
IXO134_009315	COG0840	transmembrane signaling receptor activity
IXO134_009325	COG0840	transmembrane signaling receptor activity
IXO134_009335	COG0840	transmembrane signaling receptor activity
IXO134_009345	COG0840	transmembrane signaling receptor activity
IXO134_009365	COG0745	RESPONSE REGULATOR receiver
IXO134_009375	COG0835	chemotaxis
IXO134_009385	COG1360	Flagellar Motor Protein
IXO134_009390	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO134_009410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO134_009420	COG4771	TonB-dependent receptor
IXO134_009460	COG3039	Transposase
IXO134_009605	COG3039	Transposase
IXO134_009610	COG3039	Transposase
IXO134_009630	COG3039	Transposase
IXO134_009665	COG3039	Transposase
IXO134_009675	COG3039	Transposase
IXO134_009690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO134_009690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO134_009695	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO134_009700	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO134_009700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO134_009705	COG1609	Transcriptional regulator
IXO134_009730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO134_009735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO134_009745	COG2902	Dehydrogenase
IXO134_009750	COG3039	Transposase
IXO134_009760	COG0784	Response regulator, receiver
IXO134_009760	COG2205	protein histidine kinase activity
IXO134_009760	COG5002	protein histidine kinase activity
IXO134_009765	COG2733	membrane
IXO134_009775	COG1121	(ABC) transporter
IXO134_009780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO134_009790	COG2223	nitrite transmembrane transporter activity
IXO134_009800	COG0243	molybdopterin cofactor binding
IXO134_009810	COG0477	Major facilitator Superfamily
IXO134_009820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO134_009825	COG0174	glutamine synthetase
IXO134_009860	COG3842	ATPase activity
IXO134_009870	COG1177	transmembrane transport
IXO134_009880	COG1012	belongs to the aldehyde dehydrogenase family
IXO134_009895	COG4535	Mg2 and Co2 transporter CorC
IXO134_009915	COG1702	phosphate starvation-inducible protein PhoH
IXO134_009940	COG0741	lytic transglycosylase activity
IXO134_009945	COG0723	plastoquinol--plastocyanin reductase activity
IXO134_009950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO134_009955	COG2857	Cytochrome c1
IXO134_009960	COG0625	glutathione transferase activity
IXO134_009965	COG2969	positive regulation of protein catabolic process
IXO134_010000	COG3328	transposase activity
IXO134_010005	COG3039	Transposase
IXO134_010085	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO134_010105	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO134_010110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO134_010110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO134_010115	COG0802	atpase or kinase
IXO134_010120	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO134_010125	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO134_010145	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_010155	COG0501	Belongs to the peptidase M48B family
IXO134_010165	COG2081	HI0933 family
IXO134_010170	COG4681	YaeQ
IXO134_010175	COG1671	Belongs to the UPF0178 family
IXO134_010185	COG0625	glutathione transferase activity
IXO134_010195	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IXO134_010200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO134_010205	COG0513	Belongs to the DEAD box helicase family
IXO134_010210	COG0488	(ABC) transporter
IXO134_010230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO134_010235	COG0483	inositol monophosphate 1-phosphatase activity
IXO134_010250	COG3300	MHYT domain
IXO134_010250	COG5001	Diguanylate cyclase
IXO134_010255	COG1509	lysine 2,3-aminomutase activity
IXO134_010270	COG0402	S-adenosylhomocysteine deaminase activity
IXO134_010275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO134_010300	COG4677	pectinesterase activity
IXO134_010325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO134_010350	COG2166	iron-sulfur cluster assembly
IXO134_010365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO134_010370	COG0137	argininosuccinate synthase activity
IXO134_010380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO134_010385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO134_010400	COG0165	Argininosuccinate lyase
IXO134_010420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO134_010455	COG3039	Transposase
IXO134_010470	COG4988	ABC transporter
IXO134_010475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO134_010485	COG3039	Transposase
IXO134_010575	COG3039	Transposase
IXO134_010590	COG3209	COG3209 Rhs family protein
IXO134_010600	COG3039	Transposase
IXO134_010635	COG0784	Response regulator, receiver
IXO134_010635	COG2198	Histidine kinase
IXO134_010635	COG0643	Histidine kinase
IXO134_010690	COG1684	flagellar biosynthetic protein fliR
IXO134_010705	COG3190	flagellar
IXO134_010755	COG1677	Flagellar hook-basal body complex protein FliE
IXO134_010790	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_010800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO134_010820	COG2201	protein-glutamate methylesterase activity
IXO134_010850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO134_010855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO134_010895	COG4787	bacterial-type flagellum-dependent cell motility
IXO134_010905	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO134_010910	COG1558	bacterial-type flagellum-dependent cell motility
IXO134_010920	COG0784	Response regulator, receiver
IXO134_010920	COG0835	chemotaxis
IXO134_010940	COG5002	protein histidine kinase activity
IXO134_010950	COG4585	Histidine kinase
IXO134_010955	COG5001	Diguanylate cyclase
IXO134_010980	COG0482	sulfurtransferase activity
IXO134_010995	COG0542	response to heat
IXO134_011020	COG0492	ferredoxin-NADP+ reductase activity
IXO134_011025	COG1674	ftsk spoiiie
IXO134_011045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO134_011065	COG0038	chloride channel
IXO134_011070	COG0183	Belongs to the thiolase family
IXO134_011075	COG1024	Enoyl-CoA hydratase
IXO134_011075	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO134_011090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO134_011100	COG1426	Protein conserved in bacteria
IXO134_011110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO134_011120	COG0303	'Molybdopterin
IXO134_011175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO134_011225	COG0742	ribosomal rna small subunit methyltransferase
IXO134_011230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO134_011245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO134_011250	COG0405	Gamma-glutamyltransferase
IXO134_011275	COG3039	Transposase
IXO134_011345	COG0343	queuine tRNA-ribosyltransferase activity
IXO134_011350	COG1862	Preprotein translocase
IXO134_011355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO134_011360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO134_011400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO134_011410	COG0704	Plays a role in the regulation of phosphate uptake
IXO134_011425	COG0573	inorganic phosphate transmembrane transporter activity
IXO134_011430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO134_011475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO134_011485	COG1024	Enoyl-CoA hydratase
IXO134_011495	COG0494	nUDIX hydrolase
IXO134_011540	COG0116	Belongs to the methyltransferase superfamily
IXO134_011540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO134_011565	COG0667	Aldo Keto reductase
IXO134_011575	COG2925	Exonuclease
IXO134_011605	COG0288	reversible hydration of carbon dioxide
IXO134_011635	COG0316	Belongs to the HesB IscA family
IXO134_011640	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO134_011650	COG0359	binds to the 23S rRNA
IXO134_011660	COG3115	cell septum assembly
IXO134_011675	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO134_011695	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO134_011720	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO134_011730	COG2986	histidine ammonia-lyase
IXO134_011735	COG1228	amidohydrolase
IXO134_011775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO134_011785	COG1605	Chorismate mutase
IXO134_011785	COG0077	Prephenate dehydratase
IXO134_011790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO134_011820	COG4566	intracellular signal transduction
IXO134_011865	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO134_011870	COG1469	GTP cyclohydrolase I activity
IXO134_011880	COG0617	tRNA 3'-terminal CCA addition
IXO134_011890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO134_011895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO134_011925	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO134_011945	COG3706	GGDEF domain
IXO134_011945	COG4251	negative regulation of phosphorylation
IXO134_011945	COG5001	Diguanylate cyclase
IXO134_011945	COG2203	Gaf domain
IXO134_012005	COG1595	DNA-templated transcription, initiation
IXO134_012030	COG0386	Belongs to the glutathione peroxidase family
IXO134_012110	COG3039	Transposase
IXO134_012125	COG5002	protein histidine kinase activity
IXO134_012125	COG0784	Response regulator, receiver
IXO134_012125	COG2205	protein histidine kinase activity
IXO134_012165	COG0800	Aldolase
IXO134_012170	COG0129	dihydroxy-acid dehydratase activity
IXO134_012175	COG0363	glucosamine-6-phosphate deaminase activity
IXO134_012185	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO134_012200	COG0354	folic acid binding
IXO134_012215	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO134_012230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO134_012245	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO134_012270	COG0811	peptide transport
IXO134_012285	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO134_012295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO134_012305	COG0322	excinuclease ABC activity
IXO134_012340	COG3328	transposase activity
IXO134_012360	COG3039	Transposase
IXO134_012375	COG2801	Transposase and inactivated derivatives
IXO134_012435	COG0653	protein targeting
IXO134_012730	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO134_012730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO134_012740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO134_012750	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO134_012750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO134_012765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO134_012785	COG0124	histidyl-tRNA synthetase
IXO134_012805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO134_012845	COG1012	belongs to the aldehyde dehydrogenase family
IXO134_012860	COG0167	dihydroorotate dehydrogenase activity
IXO134_012865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IXO134_012870	COG0697	spore germination
IXO134_012875	COG1794	racemase activity, acting on amino acids and derivatives
IXO134_012900	COG0671	phosphoesterase, PA-phosphatase related
IXO134_012915	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO134_012930	COG2183	response to ionizing radiation
IXO134_012940	COG0723	plastoquinol--plastocyanin reductase activity
IXO134_012940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO134_012955	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO134_012965	COG1183	phosphatidylcholine synthase activity
IXO134_012970	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_012995	COG0668	transmembrane transport
IXO134_013015	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO134_013065	COG0583	DNA-binding transcription factor activity
IXO134_013070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO134_013075	COG3002	Belongs to the UPF0753 family
IXO134_013090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO134_013110	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO134_013120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO134_013125	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO134_013135	COG0776	regulation of translation
IXO134_013140	COG0539	negative regulation of cytoplasmic translation
IXO134_013145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO134_013160	COG2957	Belongs to the agmatine deiminase family
IXO134_013170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO134_013195	COG0395	ABC-type sugar transport system, permease component
IXO134_013200	COG1175	transmembrane transport
IXO134_013230	COG2350	Protein conserved in bacteria
IXO134_013235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO134_013240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO134_013245	COG1187	pseudouridine synthase activity
IXO134_013270	COG0436	Aminotransferase
IXO134_013335	COG0277	FAD linked oxidase domain protein
IXO134_013340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO134_013350	COG0531	amino acid
IXO134_013355	COG0531	amino acid
IXO134_013360	COG0235	Class ii aldolase
IXO134_013365	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO134_013395	COG2201	protein-glutamate methylesterase activity
IXO134_013445	COG0583	DNA-binding transcription factor activity
IXO134_013455	COG3039	Transposase
IXO134_013555	COG3039	Transposase
IXO134_013565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO134_013585	COG0557	exoribonuclease II activity
IXO134_013610	COG1960	acyl-CoA dehydrogenase activity
IXO134_013615	COG2226	methyltransferase
IXO134_013620	COG0646	methionine synthase
IXO134_013620	COG1410	methionine synthase
IXO134_013625	COG0646	methionine synthase
IXO134_013625	COG1410	methionine synthase
IXO134_013635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO134_013645	COG1609	Transcriptional regulator
IXO134_013660	COG2900	Belongs to the SlyX family
IXO134_013675	COG0386	Belongs to the glutathione peroxidase family
IXO134_013685	COG1725	Transcriptional regulator
IXO134_013690	COG1131	(ABC) transporter
IXO134_013755	COG2850	peptidyl-arginine hydroxylation
IXO134_013790	COG1132	(ABC) transporter
IXO134_013805	COG0583	DNA-binding transcription factor activity
IXO134_013820	COG1605	Chorismate mutase
IXO134_013820	COG0287	Prephenate dehydrogenase
IXO134_013825	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO134_013830	COG0484	heat shock protein binding
IXO134_013835	COG0443	Heat shock 70 kDa protein
IXO134_013840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO134_013850	COG0497	DNA recombination
IXO134_013860	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO134_013865	COG2914	Belongs to the UPF0125 (RnfH) family
IXO134_013875	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO134_013890	COG1960	acyl-CoA dehydrogenase activity
IXO134_013900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO134_013955	COG2814	Major facilitator Superfamily
IXO134_013960	COG1566	PFAM secretion protein HlyD family protein
IXO134_013975	COG2207	Transcriptional regulator
IXO134_014000	COG4774	siderophore transport
IXO134_014010	COG0367	asparagine synthase
IXO134_014025	COG1393	Belongs to the ArsC family
IXO134_014040	COG3039	Transposase
IXO134_014090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO134_014105	COG0233	cytoplasmic translational termination
IXO134_014115	COG0575	Belongs to the CDS family
IXO134_014125	COG0750	zinc metalloprotease
IXO134_014145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO134_014150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO134_014170	COG0825	malonyl-CoA metabolic process
IXO134_014180	COG4771	TonB-dependent receptor
IXO134_014185	COG1131	(ABC) transporter
IXO134_014205	COG1981	membrane
IXO134_014250	COG0529	Catalyzes the synthesis of activated sulfate
IXO134_014250	COG2895	sulfate adenylyltransferase (ATP) activity
IXO134_014285	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO134_014300	COG2040	homocysteine
IXO134_014305	COG0833	amino acid
IXO134_014325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO134_014325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO134_014335	COG2878	Part of a membrane complex involved in electron transport
IXO134_014350	COG1595	DNA-templated transcription, initiation
IXO134_014375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO134_014390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO134_014395	COG0251	oxidation-reduction process
IXO134_014405	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO134_014405	COG0392	lysyltransferase activity
IXO134_014435	COG3039	Transposase
IXO134_014450	COG2814	Major facilitator Superfamily
IXO134_014455	COG1902	pentaerythritol trinitrate reductase activity
IXO134_014465	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO134_014480	COG1047	Peptidyl-prolyl cis-trans
IXO134_014520	COG3039	Transposase
IXO134_014525	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO134_014540	COG1451	nucleotide metabolic process
IXO134_014560	COG0183	Belongs to the thiolase family
IXO134_014590	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO134_014590	COG1793	dna ligase
IXO134_014600	COG1793	dna ligase
IXO134_014605	COG1201	RNA secondary structure unwinding
IXO134_014625	COG1278	Cold shock
IXO134_014630	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO134_014635	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO134_014645	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO134_014655	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO134_014685	COG3039	Transposase
IXO134_014695	COG2954	triphosphatase activity
IXO134_014710	COG1381	Involved in DNA repair and RecF pathway recombination
IXO134_014740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO134_014755	COG1024	Enoyl-CoA hydratase
IXO134_014755	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO134_014775	COG1024	Enoyl-CoA hydratase
IXO134_014780	COG1960	acyl-CoA dehydrogenase activity
IXO134_014850	COG2353	YceI-like domain
IXO134_014860	COG2353	YceI-like domain
IXO134_014875	COG1760	l-serine dehydratase
IXO134_014885	COG0626	cystathionine gamma-synthase activity
IXO134_014890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO134_014895	COG0739	heme binding
IXO134_014905	COG1272	protein, Hemolysin III
IXO134_014925	COG0463	Glycosyl transferase, family 2
IXO134_014935	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO134_014945	COG4771	TonB-dependent receptor
IXO134_014950	COG1309	transcriptional regulator
IXO134_014960	COG1960	acyl-CoA dehydrogenase activity
IXO134_014990	COG0509	glycine decarboxylation via glycine cleavage system
IXO134_015005	COG0330	HflC and HflK could
IXO134_015020	COG3956	TIGRFAM MazG family protein
IXO134_015030	COG0494	nUDIX hydrolase
IXO134_015040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO134_015045	COG0837	glucose binding
IXO134_015060	COG1388	LysM domain
IXO134_015060	COG3858	chitin binding
IXO134_015080	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO134_015120	COG3537	Alpha-1,2-mannosidase
IXO134_015160	COG3142	Participates in the control of copper homeostasis
IXO134_015165	COG1446	asparaginase
IXO134_015190	COG3039	Transposase
IXO134_015210	COG2198	Histidine kinase
IXO134_015210	COG0784	Response regulator, receiver
IXO134_015210	COG0643	Histidine kinase
IXO134_015215	COG0840	transmembrane signaling receptor activity
IXO134_015220	COG0835	chemotaxis
IXO134_015235	COG0189	ligase activity
IXO134_015245	COG1397	ADP-ribosylglycohydrolase
IXO134_015255	COG1199	ATP-dependent helicase activity
IXO134_015265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO134_015270	COG1215	transferase activity, transferring glycosyl groups
IXO134_015280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO134_015295	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IXO134_015300	COG0535	radical SAM domain protein
IXO134_015305	COG0535	radical SAM domain protein
IXO134_015330	COG1643	Atp-dependent helicase
IXO134_015335	COG0783	Belongs to the Dps family
IXO134_015340	COG0514	ATP-dependent DNA helicase (RecQ)
IXO134_015365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO134_015415	COG1187	pseudouridine synthase activity
IXO134_015425	COG0602	queuosine metabolic process
IXO134_015435	COG2885	chlorophyll binding
IXO134_015450	COG0848	biopolymer transport protein
IXO134_015460	COG0824	Thioesterase
IXO134_015465	COG2255	four-way junction helicase activity
IXO134_015475	COG0632	four-way junction helicase activity
IXO134_015605	COG3209	COG3209 Rhs family protein
IXO134_015630	COG3209	COG3209 Rhs family protein
IXO134_015630	COG3209	COG3209 Rhs family protein
IXO134_015650	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO134_015655	COG1845	cytochrome c oxidase, subunit III
IXO134_015660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO134_015675	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO134_015680	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO134_015690	COG0196	riboflavin kinase activity
IXO134_015695	COG0728	peptidoglycan biosynthetic process
IXO134_015700	COG0268	Binds directly to 16S ribosomal RNA
IXO134_015705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO134_015710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO134_015720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO134_015725	COG0824	Thioesterase
IXO134_015740	COG1946	Acyl-CoA thioesterase
IXO134_015750	COG1595	DNA-templated transcription, initiation
IXO134_015765	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO134_015805	COG1877	trehalose-phosphatase activity
IXO134_015810	COG3387	PFAM Glycoside hydrolase 15-related
IXO134_015835	COG0564	pseudouridine synthase activity
IXO134_015840	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO134_015845	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO134_015845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO134_015855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO134_015860	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO134_015900	COG2194	sulfuric ester hydrolase activity
IXO134_015905	COG4969	Belongs to the N-Me-Phe pilin family
IXO134_015915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO134_015935	COG3039	Transposase
IXO134_015985	COG1132	(ABC) transporter
IXO134_016015	COG0745	RESPONSE REGULATOR receiver
IXO134_016020	COG5000	phosphorelay sensor kinase activity
IXO134_016020	COG5002	protein histidine kinase activity
IXO134_016025	COG0475	glutathione-regulated potassium exporter activity
IXO134_016035	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO134_016055	COG1187	pseudouridine synthase activity
IXO134_016060	COG5002	protein histidine kinase activity
IXO134_016060	COG5001	Diguanylate cyclase
IXO134_016160	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_016175	COG0415	Belongs to the DNA photolyase family
IXO134_016180	COG0305	Participates in initiation and elongation during chromosome replication
IXO134_016190	COG0367	asparagine synthase
IXO134_016205	COG1960	acyl-CoA dehydrogenase activity
IXO134_016220	COG0084	hydrolase, TatD family'
IXO134_016225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO134_016285	COG0735	belongs to the Fur family
IXO134_016290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO134_016310	COG3039	Transposase
IXO134_016320	COG3039	Transposase
IXO134_016325	COG3039	Transposase
IXO134_016375	COG2205	protein histidine kinase activity
IXO134_016390	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO134_016400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO134_016415	COG0643	Histidine kinase
IXO134_016415	COG2198	Histidine kinase
IXO134_016425	COG0835	chemotaxis
IXO134_016430	COG2202	Pas domain
IXO134_016430	COG2200	EAL domain
IXO134_016430	COG2199	diguanylate cyclase activity
IXO134_016435	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO134_016450	COG3590	peptidase
IXO134_016465	COG0588	phosphoglycerate mutase activity
IXO134_016470	COG1515	deoxyribonuclease V activity
IXO134_016480	COG1741	Belongs to the pirin family
IXO134_016545	COG1741	Belongs to the pirin family
IXO134_016550	COG1966	Carbon starvation protein
IXO134_016555	COG2879	small protein
IXO134_016595	COG4251	negative regulation of phosphorylation
IXO134_016595	COG5001	Diguanylate cyclase
IXO134_016595	COG3706	GGDEF domain
IXO134_016595	COG2203	Gaf domain
IXO134_016600	COG0629	single-stranded DNA binding
IXO134_016605	COG0142	geranyltranstransferase activity
IXO134_016630	COG0527	aspartate kinase activity
IXO134_016640	COG0384	phenazine biosynthesis protein PhzF
IXO134_016650	COG1764	response to oxidative stress
IXO134_016665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO134_016670	COG1678	Uncharacterized ACR, COG1678
IXO134_016680	COG0519	Catalyzes the synthesis of GMP from XMP
IXO134_016710	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO134_016750	COG0693	protein deglycase activity
IXO134_016770	COG1959	2 iron, 2 sulfur cluster binding
IXO134_016775	COG0719	Fe-S assembly protein
IXO134_016780	COG0396	ATPase activity
IXO134_016785	COG0719	Fe-S assembly protein
IXO134_016790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO134_016800	COG2146	nitrite reductase [NAD(P)H] activity
IXO134_016825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO134_016840	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO134_016850	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO134_016855	COG0174	glutamine synthetase
IXO134_016860	COG3328	transposase activity
IXO134_016885	COG0326	Molecular chaperone. Has ATPase activity
IXO134_016890	COG2207	Transcriptional regulator
IXO134_016915	COG0657	acetylesterase activity
IXO134_016915	COG2755	lipolytic protein G-D-S-L family
IXO134_016940	COG0488	(ABC) transporter
IXO134_016975	COG4651	solute:proton antiporter activity
IXO134_016975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO134_016990	COG4772	TonB-dependent receptor
IXO134_017000	COG4264	IucA IucC family
IXO134_017005	COG2814	Major facilitator Superfamily
IXO134_017015	COG0019	diaminopimelate decarboxylase activity
IXO134_017075	COG4206	TonB-dependent receptor
IXO134_017110	COG0542	response to heat
IXO134_017155	COG0534	Mate efflux family protein
IXO134_017170	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO134_017175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO134_017180	COG0228	four-way junction DNA binding
IXO134_017205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO134_017215	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO134_017260	COG1555	photosystem II stabilization
IXO134_017265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO134_017280	COG3178	'Phosphotransferase
IXO134_017285	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO134_017295	COG0628	permease
IXO134_017305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO134_017320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO134_017345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO134_017355	COG0271	Belongs to the BolA IbaG family
IXO134_017365	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO134_017375	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO134_017380	COG1137	ATPase activity
IXO134_017395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO134_017400	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO134_017405	COG1660	Displays ATPase and GTPase activities
IXO134_017420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO134_017425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO134_017430	COG2239	Acts as a magnesium transporter
IXO134_017440	COG1294	oxidase, subunit
IXO134_017445	COG1271	oxidase subunit
IXO134_017465	COG1113	amino acid transport
IXO134_017480	COG2197	response regulator
IXO134_017485	COG0531	amino acid
IXO134_017545	COG0754	glutathionylspermidine amidase activity
IXO134_017570	COG1842	Phage shock protein A
IXO134_017585	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO134_017590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXO134_017600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO134_017665	COG2801	Transposase and inactivated derivatives
IXO134_017680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO134_017725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO134_017730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO134_017755	COG3039	Transposase
IXO134_017770	COG0745	RESPONSE REGULATOR receiver
IXO134_017775	COG2205	protein histidine kinase activity
IXO134_017795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO134_017825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO134_017825	COG3453	Protein conserved in bacteria
IXO134_017830	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO134_017835	COG4149	molybdate abc transporter
IXO134_017840	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO134_017860	COG0642	Histidine kinase
IXO134_017875	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_017885	COG1022	Amp-dependent synthetase and ligase
IXO134_017910	COG1376	ErfK ybiS ycfS ynhG family protein
IXO134_017915	COG0739	heme binding
IXO134_017925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO134_017930	COG1301	dicarboxylic acid transport
IXO134_017950	COG2304	oxidoreductase activity
IXO134_017970	COG0714	Associated with various cellular activities
IXO134_018015	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO134_018040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO134_018050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO134_018075	COG1561	YicC-like family, N-terminal region
IXO134_018080	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO134_018095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO134_018125	COG0006	proline dipeptidase activity
IXO134_018150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO134_018160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO134_018170	COG2912	Transglutaminase-like superfamily
IXO134_018175	COG1773	rubredoxin
IXO134_018180	COG0352	thiamine-phosphate diphosphorylase activity
IXO134_018245	COG0280	phosphate acetyltransferase
IXO134_018245	COG0281	malic enzyme
IXO134_018265	COG4191	Histidine kinase
IXO134_018280	COG0583	DNA-binding transcription factor activity
IXO134_018295	COG2197	response regulator
IXO134_018305	COG0642	Histidine kinase
IXO134_018325	COG2851	Citrate transporter
IXO134_018330	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_018335	COG1609	Transcriptional regulator
IXO134_018345	COG2211	Major facilitator Superfamily
IXO134_018370	COG1162	GTPase activity
IXO134_018395	COG0726	polysaccharide deacetylase
IXO134_018400	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO134_018425	COG3039	Transposase
IXO134_018435	COG3039	Transposase
IXO134_018480	COG0242	peptide deformylase activity
IXO134_018500	COG0714	Associated with various cellular activities
IXO134_018520	COG0537	adenosine 5'-monophosphoramidase activity
IXO134_018550	COG0314	molybdopterin synthase activity
IXO134_018555	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO134_018560	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO134_018570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO134_018575	COG1234	tRNA 3'-trailer cleavage
IXO134_018580	COG3642	lipopolysaccharide core region biosynthetic process
IXO134_018585	COG0859	PFAM glycosyl transferase family 9
IXO134_018595	COG0582	viral genome integration into host DNA
IXO134_018650	COG0631	protein serine/threonine phosphatase activity
IXO134_018660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO134_018685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO134_018725	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO134_018775	COG0473	3-isopropylmalate dehydrogenase activity
IXO134_018800	COG4783	chaperone-mediated protein folding
IXO134_018815	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO134_018825	COG0438	transferase activity, transferring glycosyl groups
IXO134_018830	COG0671	phosphoesterase, PA-phosphatase related
IXO134_018835	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO134_018855	COG2833	Protein of unknown function (DUF455)
IXO134_018875	COG0285	dihydrofolate synthase activity
IXO134_018885	COG0588	phosphoglycerate mutase activity
IXO134_018915	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO134_018920	COG4208	sulfate ABC transporter
IXO134_018925	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO134_018930	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO134_018935	COG0156	8-amino-7-oxononanoate synthase activity
IXO134_018960	COG0604	alcohol dehydrogenase
IXO134_018965	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO134_018965	COG1902	pentaerythritol trinitrate reductase activity
IXO134_019085	COG3386	PFAM SMP-30 Gluconolaconase
IXO134_019105	COG1024	Enoyl-CoA hydratase
IXO134_019115	COG0318	PFAM AMP-dependent synthetase and ligase
IXO134_019120	COG0583	DNA-binding transcription factor activity
IXO134_019160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO134_019165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO134_019175	COG2096	Adenosyltransferase
IXO134_019180	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO134_019195	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO134_019205	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO134_019210	COG2967	ApaG domain
IXO134_019235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO134_019255	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO134_019275	COG0642	Histidine kinase
IXO134_019290	COG4181	ATPase activity
IXO134_019300	COG2175	clavaminate synthase activity
IXO134_019355	COG0667	Aldo Keto reductase
IXO134_019365	COG3039	Transposase
IXO134_019375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO134_019380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO134_019390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO134_019405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO134_019460	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO134_019465	COG2226	methyltransferase
IXO134_019515	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_019515	COG3321	synthase
IXO134_019515	COG0604	alcohol dehydrogenase
IXO134_019525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO134_019540	COG0494	nUDIX hydrolase
IXO134_019555	COG1388	LysM domain
IXO134_019555	COG4942	peptidase
IXO134_019565	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO134_019580	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO134_019585	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO134_019590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO134_019605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO134_019610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO134_019625	COG3116	cell division
IXO134_019630	COG0275	rRNA processing
IXO134_019665	COG0792	nuclease activity
IXO134_019670	COG1988	membrane-bound metal-dependent
IXO134_019675	COG0277	FAD linked oxidase domain protein
IXO134_019680	COG0745	RESPONSE REGULATOR receiver
IXO134_019685	COG2205	protein histidine kinase activity
IXO134_019695	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO134_019700	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO134_019720	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO134_019725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO134_019730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO134_019750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO134_019750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO134_019770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO134_019790	COG0488	(ABC) transporter
IXO134_019840	COG2205	protein histidine kinase activity
IXO134_019885	COG2205	protein histidine kinase activity
IXO134_019900	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO134_019935	COG3039	Transposase
IXO134_019955	COG3039	Transposase
IXO134_020040	COG1649	PFAM Uncharacterised BCR, COG1649
IXO134_020040	COG0726	polysaccharide deacetylase
IXO134_020045	COG1215	transferase activity, transferring glycosyl groups
IXO134_020055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO134_020060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO134_020065	COG1609	Transcriptional regulator
IXO134_020075	COG2188	Transcriptional regulator
IXO134_020090	COG3250	beta-galactosidase activity
IXO134_020140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO134_020145	COG4191	Histidine kinase
IXO134_020150	COG0784	Response regulator, receiver
IXO134_020155	COG4251	negative regulation of phosphorylation
IXO134_020160	COG2823	Periplasmic or secreted lipoprotein
IXO134_020165	COG0673	inositol 2-dehydrogenase activity
IXO134_020170	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO134_020205	COG1051	belongs to the nudix hydrolase family
IXO134_020205	COG1056	cytidyltransferase-related domain
IXO134_020230	COG2921	Belongs to the UPF0250 family
IXO134_020240	COG1686	Belongs to the peptidase S11 family
IXO134_020245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO134_020250	COG2951	lytic endotransglycosylase activity
IXO134_020320	COG0772	Belongs to the SEDS family
IXO134_020335	COG1792	Involved in formation and maintenance of cell shape
IXO134_020340	COG1077	Cell shape determining protein MreB Mrl
IXO134_020345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO134_020395	COG2199	diguanylate cyclase activity
IXO134_020400	COG0308	aminopeptidase N
IXO134_020430	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO134_020460	COG0436	Aminotransferase
IXO134_020465	COG3039	Transposase
IXO134_020470	COG3039	Transposase
IXO134_020490	COG1505	serine-type exopeptidase activity
IXO134_020515	COG0181	hydroxymethylbilane synthase activity
IXO134_020525	COG3275	phosphorelay sensor kinase activity
IXO134_020565	COG0659	secondary active sulfate transmembrane transporter activity
IXO134_020570	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO134_020570	COG5297	Belongs to the glycosyl hydrolase family 6
IXO134_020645	COG0598	Magnesium transport protein CorA
IXO134_020655	COG1113	amino acid transport
IXO134_020660	COG5297	Belongs to the glycosyl hydrolase family 6
IXO134_020665	COG4305	rare lipoprotein A
IXO134_020670	COG0697	spore germination
IXO134_020725	COG4221	oxidoreductase activity
IXO134_020755	COG0456	acetyltransferase
IXO134_020765	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO134_020810	COG2111	Na H antiporter
IXO134_020810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO134_020815	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO134_020820	COG0651	ATP synthesis coupled electron transport
IXO134_020830	COG2212	antiporter activity
IXO134_020835	COG1320	monovalent cation:proton antiporter activity
IXO134_020850	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO134_020870	COG3104	oligopeptide transport
IXO134_020875	COG3483	tryptophan 2,3-dioxygenase activity
IXO134_020885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IXO134_020920	COG0183	Belongs to the thiolase family
IXO134_020965	COG3039	Transposase
IXO134_021000	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO134_021020	COG4948	Mandelate Racemase Muconate Lactonizing
IXO134_021045	COG0531	amino acid
IXO134_021070	COG4682	membrane
IXO134_021080	COG2133	pyrroloquinoline quinone binding
IXO134_021120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO134_021125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO134_021135	COG1610	YqeY-like protein
IXO134_021145	COG1295	ribonuclease BN
IXO134_021150	COG0358	DNA primase activity
IXO134_021215	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO134_021230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO134_021280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO134_021285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO134_021290	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO134_021300	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO134_021305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO134_021315	COG0134	indole-3-glycerol-phosphate synthase activity
IXO134_021320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO134_021385	COG3039	Transposase
IXO134_021400	COG3039	Transposase
IXO134_021410	COG3328	transposase activity
IXO134_021415	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO134_021415	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO134_021425	COG1473	amidohydrolase
IXO134_021430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO134_021435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO134_021450	COG5383	Protein conserved in bacteria
IXO134_021490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO134_021495	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO134_021510	COG0028	Belongs to the TPP enzyme family
IXO134_021515	COG4191	Histidine kinase
IXO134_021540	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO134_021555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO134_021560	COG3177	Filamentation induced by cAMP protein fic
IXO134_021575	COG0596	Alpha beta hydrolase
IXO134_021580	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO134_021585	COG0318	PFAM AMP-dependent synthetase and ligase
IXO134_021590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO134_021640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO134_021650	COG0129	dihydroxy-acid dehydratase activity
IXO134_021675	COG3039	Transposase
IXO134_021685	COG0408	coproporphyrinogen oxidase activity
IXO134_021725	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXO134_021730	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXO134_021790	COG2353	YceI-like domain
IXO134_021820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO134_021835	COG3386	PFAM SMP-30 Gluconolaconase
IXO134_021875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO134_021890	COG4771	TonB-dependent receptor
IXO134_021900	COG0459	protein refolding
IXO134_021925	COG1252	NADH dehydrogenase
IXO134_021935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO134_021940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO134_021945	COG3437	response regulator, receiver
IXO134_021950	COG2177	Part of the ABC transporter FtsEX involved in
IXO134_021955	COG2884	Cell division ATP-binding protein ftsE
IXO134_021965	COG3118	belongs to the thioredoxin family
IXO134_021970	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO134_021985	COG0729	surface antigen
IXO134_021990	COG2911	Protein conserved in bacteria
IXO134_022025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO134_022040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO134_022095	COG1733	regulation of RNA biosynthetic process
IXO134_022100	COG0702	epimerase
IXO134_022130	COG0583	DNA-binding transcription factor activity
IXO134_022135	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO134_022155	COG0745	RESPONSE REGULATOR receiver
IXO134_022185	COG1902	pentaerythritol trinitrate reductase activity
IXO134_022190	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO134_022200	COG2814	Major facilitator Superfamily
IXO134_022205	COG0583	DNA-binding transcription factor activity
IXO134_022220	COG0084	hydrolase, TatD family'
IXO134_022265	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO134_022285	COG2072	flavoprotein involved in K transport
IXO134_022340	COG4770	biotin carboxylase activity
IXO134_022345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO134_022350	COG1960	acyl-CoA dehydrogenase activity
IXO134_022405	COG0523	cobalamin synthesis protein
IXO134_022415	COG0697	spore germination
IXO134_022425	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO134_022440	COG4771	TonB-dependent receptor
IXO134_022445	COG0457	Tetratricopeptide repeat
IXO134_022455	COG0752	glycyl-tRNA synthetase alpha subunit
IXO134_022460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO134_022475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO134_022475	COG0519	Catalyzes the synthesis of GMP from XMP
IXO134_022485	COG0805	protein transport
IXO134_022495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO134_022505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO134_022530	COG2974	May be involved in recombination
IXO134_022535	COG0037	tRNA processing
IXO134_022550	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO134_022560	COG4948	Mandelate Racemase Muconate Lactonizing
IXO134_022570	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO134_022575	COG0246	Mannitol dehydrogenase
IXO134_022600	COG3693	PFAM glycoside hydrolase, family 10
IXO134_022620	COG2211	Major facilitator Superfamily
IXO134_022670	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IXO134_022710	COG1846	Transcriptional regulator
IXO134_022715	COG1764	response to oxidative stress
IXO134_022795	COG3549	Plasmid maintenance system killer
IXO134_022805	COG1074	ATP-dependent DNA helicase activity
IXO134_022810	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO134_022855	COG2032	superoxide dismutase activity
IXO134_022860	COG2032	superoxide dismutase activity
IXO134_022865	COG2204	response regulator
IXO134_022870	COG3852	Histidine kinase
IXO134_022875	COG0004	ammonium transporteR
IXO134_022880	COG0347	Belongs to the P(II) protein family
IXO134_022885	COG0174	glutamine synthetase
IXO134_022890	COG1968	undecaprenyl-diphosphatase activity
IXO134_022935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO134_022945	COG2062	phosphohistidine phosphatase, SixA
IXO134_022950	COG0489	protein tyrosine kinase activity
IXO134_022970	COG1396	sequence-specific DNA binding
IXO134_022975	COG3550	peptidyl-serine autophosphorylation
IXO134_022980	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO134_022985	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO134_023000	COG0517	IMP dehydrogenase activity
IXO134_023000	COG1125	glycine betaine transport
IXO134_023015	COG1119	ATPase activity
IXO134_023025	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO134_023040	COG3039	Transposase
IXO134_023065	COG0656	L-ascorbic acid biosynthetic process
IXO134_023070	COG2130	NADP-dependent
IXO134_023075	COG0667	Aldo Keto reductase
IXO134_023085	COG1187	pseudouridine synthase activity
IXO134_023095	COG1643	Atp-dependent helicase
IXO134_023100	COG4807	Protein conserved in bacteria
IXO134_023105	COG4948	Mandelate Racemase Muconate Lactonizing
IXO134_023110	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO134_023115	COG1028	Short-chain dehydrogenase reductase Sdr
IXO134_023135	COG3507	Belongs to the glycosyl hydrolase 43 family
IXO134_023175	COG3162	membrane
IXO134_023180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO134_023195	COG0708	Exodeoxyribonuclease III
IXO134_023210	COG2091	lysine biosynthetic process via aminoadipic acid
IXO134_023220	COG3540	Alkaline phosphatase
IXO134_023225	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO134_023250	COG2159	amidohydrolase
IXO134_023260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO134_023265	COG0583	DNA-binding transcription factor activity
IXO134_023270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO134_023285	COG0210	DNA helicase
IXO134_023305	COG0531	amino acid
IXO134_023310	COG1322	Protein conserved in bacteria
IXO134_023320	COG0386	Belongs to the glutathione peroxidase family
IXO134_023375	COG0793	Belongs to the peptidase S41A family
IXO134_023380	COG4942	peptidase
IXO134_023390	COG2234	aminopeptidase activity
IXO134_023435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO134_023440	COG0302	gtp cyclohydrolase
IXO134_023460	COG0477	Major facilitator Superfamily
IXO134_023545	COG1929	Belongs to the glycerate kinase type-1 family
IXO134_023550	COG2271	Major facilitator Superfamily
IXO134_023565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO134_023570	COG0861	Integral membrane protein TerC family
IXO134_023580	COG0584	glycerophosphoryl diester phosphodiesterase
IXO134_023590	COG0671	phosphoesterase, PA-phosphatase related
IXO134_023600	COG0726	polysaccharide deacetylase
IXO134_023720	COG0489	protein tyrosine kinase activity
IXO134_023745	COG3039	Transposase
IXO134_023805	COG3704	protein secretion by the type IV secretion system
IXO134_023815	COG3504	Conjugal transfer protein