locus-tag	class	description
IXO220_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO220_000020	COG0187	DNA topoisomerase II activity
IXO220_000030	COG0501	Belongs to the peptidase M48B family
IXO220_000060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO220_000070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO220_000080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO220_000090	COG4772	TonB-dependent receptor
IXO220_000105	COG3039	Transposase
IXO220_000110	COG1304	FMN binding
IXO220_000130	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO220_000140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO220_000225	COG2826	transposase and inactivated derivatives, IS30 family
IXO220_000250	COG3039	Transposase
IXO220_000260	COG1090	epimerase
IXO220_000270	COG0642	Histidine kinase
IXO220_000280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO220_000390	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO220_000465	COG3264	Mechanosensitive ion channel
IXO220_000465	COG1511	domain protein
IXO220_000480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO220_000485	COG2354	Protein conserved in bacteria
IXO220_000490	COG1649	PFAM Uncharacterised BCR, COG1649
IXO220_000510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO220_000535	COG0702	epimerase
IXO220_000550	COG1858	cytochrome C peroxidase
IXO220_000630	COG0513	Belongs to the DEAD box helicase family
IXO220_000635	COG3039	Transposase
IXO220_000680	COG1136	(ABC) transporter
IXO220_000720	COG1136	(ABC) transporter
IXO220_000760	COG1272	protein, Hemolysin III
IXO220_000765	COG1111	helicase
IXO220_000765	COG1205	dead DEAH box helicase
IXO220_000825	COG0067	glutamate synthase
IXO220_000825	COG0069	glutamate synthase activity
IXO220_000825	COG0070	glutamate synthase
IXO220_000830	COG0493	'glutamate synthase
IXO220_000875	COG1609	Transcriptional regulator
IXO220_000905	COG0366	Alpha amylase catalytic
IXO220_000910	COG0366	Alpha amylase catalytic
IXO220_000955	COG0606	chelatase, subunit chli
IXO220_000995	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO220_001000	COG1166	arginine decarboxylase activity
IXO220_001065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO220_001090	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_001115	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO220_001130	COG0210	DNA helicase
IXO220_001145	COG3132	Protein of unknown function, DUF480
IXO220_001150	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO220_001155	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO220_001190	COG2937	Belongs to the GPAT DAPAT family
IXO220_001230	COG3186	Phenylalanine-4-hydroxylase
IXO220_001235	COG1522	sequence-specific DNA binding
IXO220_001280	COG1064	alcohol dehydrogenase
IXO220_001285	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO220_001295	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO220_001305	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO220_001325	COG0676	glucose-6-phosphate 1-epimerase activity
IXO220_001390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO220_001415	COG2853	Lipoprotein
IXO220_001430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO220_001435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO220_001440	COG1127	ABC transporter
IXO220_001515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO220_001525	COG3039	Transposase
IXO220_001530	COG3265	gluconokinase activity
IXO220_001535	COG2211	Major facilitator Superfamily
IXO220_001540	COG3459	Glycosyltransferase 36 associated
IXO220_001550	COG2205	protein histidine kinase activity
IXO220_001560	COG1414	Transcriptional regulator
IXO220_001565	COG0738	Major facilitator superfamily
IXO220_001570	COG3254	rhamnose metabolic process
IXO220_001600	COG0339	signal peptide processing
IXO220_001630	COG0564	pseudouridine synthase activity
IXO220_001640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO220_001650	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO220_001715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO220_001725	COG0842	Transport permease protein
IXO220_001730	COG1131	(ABC) transporter
IXO220_001760	COG1476	TRANSCRIPTIONal
IXO220_001770	COG4555	ABC transporter
IXO220_001805	COG0625	glutathione transferase activity
IXO220_001850	COG0583	DNA-binding transcription factor activity
IXO220_001890	COG1199	ATP-dependent helicase activity
IXO220_001910	COG1566	PFAM secretion protein HlyD family protein
IXO220_001935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO220_001975	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO220_001975	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO220_001980	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO220_001995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO220_002030	COG3237	CsbD-like
IXO220_002035	COG0180	Tryptophanyl-tRNA synthetase
IXO220_002040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO220_002085	COG0753	catalase activity
IXO220_002100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO220_002110	COG0628	permease
IXO220_002120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO220_002125	COG1040	competence protein
IXO220_002130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO220_002135	COG0156	8-amino-7-oxononanoate synthase activity
IXO220_002145	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_002160	COG0463	Glycosyl transferase, family 2
IXO220_002170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO220_002175	COG3100	YcgL domain-containing protein
IXO220_002190	COG3387	PFAM Glycoside hydrolase 15-related
IXO220_002195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO220_002210	COG2239	Acts as a magnesium transporter
IXO220_002225	COG1042	CoA-binding domain protein
IXO220_002225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO220_002225	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO220_002235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO220_002240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO220_002280	COG3485	protocatechuate 3,4-dioxygenase
IXO220_002300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO220_002305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO220_002330	COG4221	oxidoreductase activity
IXO220_002355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO220_002380	COG0463	Glycosyl transferase, family 2
IXO220_002395	COG1475	DNA binding
IXO220_002400	COG1192	Involved in chromosome partitioning
IXO220_002415	COG0708	Exodeoxyribonuclease III
IXO220_002420	COG2211	Major facilitator Superfamily
IXO220_002435	COG0739	heme binding
IXO220_002480	COG0745	RESPONSE REGULATOR receiver
IXO220_002520	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO220_002535	COG2814	Major facilitator Superfamily
IXO220_002550	COG1289	transmembrane transporter activity
IXO220_002575	COG0151	Belongs to the GarS family
IXO220_002585	COG0138	bifunctional purine biosynthesis protein purh
IXO220_002600	COG3039	Transposase
IXO220_002605	COG2267	carboxylic ester hydrolase activity
IXO220_002610	COG2267	carboxylic ester hydrolase activity
IXO220_002630	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO220_002675	COG0439	Biotin carboxylase
IXO220_002685	COG0511	ligase activity, forming carbon-carbon bonds
IXO220_002690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO220_002700	COG1324	tolerance protein
IXO220_002740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO220_002765	COG0534	Mate efflux family protein
IXO220_002770	COG0616	signal peptide processing
IXO220_002780	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_002795	COG0009	L-threonylcarbamoyladenylate synthase
IXO220_002800	COG1754	DNA topoisomerase type I activity
IXO220_002800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO220_002815	COG2922	Belongs to the Smg family
IXO220_002820	COG0758	DNA mediated transformation
IXO220_002825	COG1652	LysM domain
IXO220_002830	COG0242	peptide deformylase activity
IXO220_002835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO220_002840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO220_002840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO220_002890	COG1560	Kdo2-lipid A biosynthetic process
IXO220_002900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO220_003045	COG3039	Transposase
IXO220_003055	COG1271	oxidase subunit
IXO220_003110	COG2972	Histidine kinase
IXO220_003125	COG0531	amino acid
IXO220_003145	COG3590	peptidase
IXO220_003155	COG0667	Aldo Keto reductase
IXO220_003170	COG3384	dioxygenase
IXO220_003180	COG1573	uracil-dna glycosylase
IXO220_003190	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO220_003200	COG0025	NhaP-type Na H and K H
IXO220_003205	COG1131	(ABC) transporter
IXO220_003210	COG0842	Transport permease protein
IXO220_003225	COG1404	Belongs to the peptidase S8 family
IXO220_003240	COG0745	RESPONSE REGULATOR receiver
IXO220_003290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO220_003315	COG2202	Pas domain
IXO220_003315	COG2205	protein histidine kinase activity
IXO220_003345	COG2813	Specifically methylates the guanine in position
IXO220_003350	COG1187	pseudouridine synthase activity
IXO220_003355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO220_003390	COG0697	spore germination
IXO220_003400	COG2011	ABC-type metal ion transport system permease component
IXO220_003430	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO220_003440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO220_003460	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO220_003470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO220_003480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO220_003485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO220_003490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO220_003495	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXO220_003545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO220_003550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO220_003600	COG0339	signal peptide processing
IXO220_003635	COG1956	GAF domain-containing protein
IXO220_003640	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO220_003650	COG0720	synthase
IXO220_003655	COG0513	Belongs to the DEAD box helicase family
IXO220_003665	COG0625	glutathione transferase activity
IXO220_003695	COG0626	cystathionine gamma-synthase activity
IXO220_003735	COG3328	transposase activity
IXO220_003760	COG2086	electron transfer activity
IXO220_003785	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO220_003785	COG0662	Cupin 2, conserved barrel domain protein
IXO220_003790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO220_003825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO220_003825	COG3218	ABC-type transport auxiliary lipoprotein component
IXO220_003830	COG1127	ABC transporter
IXO220_003835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO220_003855	COG0442	prolyl-tRNA aminoacylation
IXO220_003865	COG1183	phosphatidylcholine synthase activity
IXO220_003895	COG3039	Transposase
IXO220_003930	COG3039	Transposase
IXO220_003960	COG0525	valine-tRNA ligase activity
IXO220_003975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO220_003985	COG0795	lipopolysaccharide-transporting ATPase activity
IXO220_004000	COG4974	Belongs to the 'phage' integrase family
IXO220_004005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO220_004010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXO220_004010	COG0047	phosphoribosylformylglycinamidine synthase activity
IXO220_004015	COG5295	Hep Hag repeat protein
IXO220_004025	COG1404	Belongs to the peptidase S8 family
IXO220_004035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO220_004045	COG1459	type II secretion system
IXO220_004050	COG2165	general secretion pathway protein
IXO220_004055	COG4970	Tfp pilus assembly protein FimT
IXO220_004060	COG2165	general secretion pathway protein
IXO220_004065	COG4795	General secretion pathway protein
IXO220_004070	COG3156	type II secretion system protein K
IXO220_004075	COG3166	PFAM Fimbrial assembly family protein
IXO220_004090	COG1450	Type ii and iii secretion system protein
IXO220_004105	COG2188	Transcriptional regulator
IXO220_004155	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO220_004160	COG1518	maintenance of DNA repeat elements
IXO220_004195	COG3039	Transposase
IXO220_004210	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO220_004235	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_004240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO220_004250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO220_004255	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO220_004285	COG3829	transcription factor binding
IXO220_004360	COG2826	transposase and inactivated derivatives, IS30 family
IXO220_004370	COG0678	peroxiredoxin activity
IXO220_004390	COG0330	HflC and HflK could
IXO220_004395	COG0330	HflC and HflK could
IXO220_004405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO220_004410	COG0308	aminopeptidase N
IXO220_004470	COG1560	Kdo2-lipid A biosynthetic process
IXO220_004475	COG1519	Transferase
IXO220_004480	COG1538	Outer membrane efflux protein
IXO220_004485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO220_004515	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO220_004520	COG0066	3-isopropylmalate dehydratase activity
IXO220_004525	COG2226	methyltransferase
IXO220_004555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO220_004565	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO220_004570	COG3710	Transcriptional regulator
IXO220_004595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO220_004615	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO220_004650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO220_004660	COG3781	membrane
IXO220_004795	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO220_004815	COG1217	gtp-binding protein TYPA
IXO220_004820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO220_004825	COG0039	L-malate dehydrogenase activity
IXO220_004830	COG0625	glutathione transferase activity
IXO220_004845	COG3039	Transposase
IXO220_004870	COG0584	glycerophosphoryl diester phosphodiesterase
IXO220_004905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO220_004940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO220_004945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO220_004950	COG0583	DNA-binding transcription factor activity
IXO220_004955	COG3634	alkyl hydroperoxide reductase activity
IXO220_004965	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO220_005005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO220_005005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO220_005020	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO220_005045	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO220_005070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO220_005080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO220_005110	COG1295	ribonuclease BN
IXO220_005115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO220_005135	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO220_005145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO220_005150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO220_005160	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO220_005175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO220_005185	COG0193	aminoacyl-tRNA hydrolase activity
IXO220_005190	COG0012	GTP binding
IXO220_005220	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO220_005225	COG0250	Participates in transcription elongation, termination and antitermination
IXO220_005230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO220_005240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO220_005245	COG0222	ribosome binding
IXO220_005250	COG0085	RNA polymerase activity
IXO220_005255	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO220_005260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO220_005265	COG0049	tRNA binding
IXO220_005285	COG0051	transcription antitermination factor activity, RNA binding
IXO220_005290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO220_005295	COG0088	Forms part of the polypeptide exit tunnel
IXO220_005300	COG0089	rRNA binding
IXO220_005315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO220_005325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO220_005330	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO220_005335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO220_005340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO220_005350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO220_005380	COG1841	ribosomal large subunit assembly
IXO220_005390	COG0201	protein transport
IXO220_005400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO220_005405	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO220_005415	COG0203	ribosomal protein L17
IXO220_005475	COG3551	Protein conserved in bacteria
IXO220_005505	COG2194	sulfuric ester hydrolase activity
IXO220_005515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO220_005520	COG0745	RESPONSE REGULATOR receiver
IXO220_005525	COG0642	Histidine kinase
IXO220_005535	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO220_005540	COG2894	cell division
IXO220_005555	COG4585	Histidine kinase
IXO220_005560	COG2197	response regulator
IXO220_005575	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO220_005600	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IXO220_005605	COG2963	transposase activity
IXO220_005710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO220_005855	COG3039	Transposase
IXO220_005870	COG3039	Transposase
IXO220_005930	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO220_005950	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO220_005955	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO220_005960	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO220_005975	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO220_006010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO220_006015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO220_006050	COG0587	DNA-directed DNA polymerase activity
IXO220_006065	COG1297	OPT oligopeptide transporter protein
IXO220_006085	COG0823	Involved in the tonB-independent uptake of proteins
IXO220_006085	COG1506	peptidase
IXO220_006105	COG1917	Cupin 2, conserved barrel domain protein
IXO220_006105	COG2207	Transcriptional regulator
IXO220_006130	COG0753	catalase activity
IXO220_006160	COG0126	phosphoglycerate kinase activity
IXO220_006170	COG0469	pyruvate kinase activity
IXO220_006175	COG3588	fructose-bisphosphate aldolase
IXO220_006180	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO220_006225	COG0784	Response regulator, receiver
IXO220_006225	COG2198	Histidine kinase
IXO220_006225	COG2205	protein histidine kinase activity
IXO220_006245	COG0175	sulfate reduction
IXO220_006250	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO220_006255	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO220_006260	COG0175	sulfate reduction
IXO220_006265	COG0529	Catalyzes the synthesis of activated sulfate
IXO220_006265	COG2895	sulfate adenylyltransferase (ATP) activity
IXO220_006275	COG3039	Transposase
IXO220_006285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO220_006290	COG0308	aminopeptidase N
IXO220_006315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO220_006335	COG1970	mechanosensitive ion channel activity
IXO220_006365	COG3273	potassium ion transport
IXO220_006365	COG0471	metal ion transport
IXO220_006375	COG2022	thiamine diphosphate biosynthetic process
IXO220_006490	COG3118	belongs to the thioredoxin family
IXO220_006515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO220_006540	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO220_006570	COG2968	Membrane
IXO220_006585	COG3164	Protein of unknown function
IXO220_006595	COG0312	modulator of DNA gyrase
IXO220_006600	COG3028	Belongs to the UPF0307 family
IXO220_006605	COG0312	modulator of DNA gyrase
IXO220_006630	COG0142	geranyltranstransferase activity
IXO220_006635	COG1722	exodeoxyribonuclease VII activity
IXO220_006640	COG0037	tRNA processing
IXO220_006645	COG1785	Belongs to the alkaline phosphatase family
IXO220_006650	COG1301	dicarboxylic acid transport
IXO220_006665	COG0791	NLP P60 protein
IXO220_006670	COG0791	NLP P60 protein
IXO220_006675	COG1047	Peptidyl-prolyl cis-trans
IXO220_006680	COG2311	Membrane
IXO220_006685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO220_006725	COG0489	protein tyrosine kinase activity
IXO220_006730	COG0717	Belongs to the dCTP deaminase family
IXO220_006750	COG0412	Dienelactone hydrolase
IXO220_006760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO220_006800	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO220_006805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO220_006810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO220_006815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO220_006835	COG0101	tRNA pseudouridine synthase activity
IXO220_006840	COG0135	phosphoribosylanthranilate isomerase activity
IXO220_006860	COG0159	tryptophan synthase activity
IXO220_006865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO220_006870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO220_006920	COG0149	triose-phosphate isomerase activity
IXO220_006935	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO220_006945	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO220_006950	COG0649	NAD binding
IXO220_006955	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO220_006960	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO220_006965	COG1034	ATP synthesis coupled electron transport
IXO220_006970	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO220_007000	COG1007	ATP synthesis coupled electron transport
IXO220_007010	COG0779	Required for maturation of 30S ribosomal subunits
IXO220_007015	COG0195	Participates in both transcription termination and antitermination
IXO220_007020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IXO220_007035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO220_007040	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO220_007075	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO220_007085	COG2095	MarC family integral membrane protein
IXO220_007100	COG1611	Belongs to the LOG family
IXO220_007295	COG3179	chitinase
IXO220_007340	COG4695	Portal protein
IXO220_007395	COG3039	Transposase
IXO220_007410	COG4969	Belongs to the N-Me-Phe pilin family
IXO220_007415	COG0556	nucleotide-excision repair
IXO220_007455	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO220_007470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO220_007525	COG0438	transferase activity, transferring glycosyl groups
IXO220_007530	COG0438	transferase activity, transferring glycosyl groups
IXO220_007540	COG0438	transferase activity, transferring glycosyl groups
IXO220_007580	COG3040	lipid binding
IXO220_007660	COG0784	Response regulator, receiver
IXO220_007660	COG4191	Histidine kinase
IXO220_007680	COG0552	protein localization to endoplasmic reticulum
IXO220_007690	COG3938	Belongs to the proline racemase family
IXO220_007695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO220_007710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO220_007720	COG0006	proline dipeptidase activity
IXO220_007735	COG0531	amino acid
IXO220_007785	COG4206	TonB-dependent receptor
IXO220_007810	COG3328	transposase activity
IXO220_007870	COG0746	molybdenum cofactor guanylyltransferase activity
IXO220_007895	COG1648	precorrin-2 dehydrogenase activity
IXO220_007895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO220_007935	COG3039	Transposase
IXO220_007940	COG3039	Transposase
IXO220_007975	COG3039	Transposase
IXO220_007990	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO220_008010	COG1054	Belongs to the UPF0176 family
IXO220_008025	COG1530	ribonuclease E activity
IXO220_008035	COG3064	Membrane
IXO220_008040	COG0428	transporter
IXO220_008045	COG0428	transporter
IXO220_008055	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO220_008105	COG3039	Transposase
IXO220_008225	COG0631	protein serine/threonine phosphatase activity
IXO220_008230	COG0515	serine threonine protein kinase
IXO220_008260	COG1858	cytochrome C peroxidase
IXO220_008310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO220_008315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO220_008335	COG2201	protein-glutamate methylesterase activity
IXO220_008380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO220_008400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO220_008415	COG1595	DNA-templated transcription, initiation
IXO220_008465	COG2244	polysaccharide biosynthetic process
IXO220_008495	COG2264	protein methyltransferase activity
IXO220_008505	COG0438	transferase activity, transferring glycosyl groups
IXO220_008520	COG1136	(ABC) transporter
IXO220_008525	COG1132	(ABC) transporter
IXO220_008535	COG0477	Major facilitator Superfamily
IXO220_008540	COG3039	Transposase
IXO220_008550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO220_008565	COG1253	flavin adenine dinucleotide binding
IXO220_008575	COG0306	phosphate transporter
IXO220_008605	COG0504	CTP synthase activity
IXO220_008610	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO220_008620	COG0148	phosphopyruvate hydratase activity
IXO220_008625	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO220_008630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO220_008640	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO220_008650	COG2840	Smr protein MutS2
IXO220_008655	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO220_008660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO220_008665	COG1238	metal cluster binding
IXO220_008680	COG1534	Rna-binding protein
IXO220_008685	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO220_008695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO220_008710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO220_008715	COG1546	Belongs to the CinA family
IXO220_008730	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO220_008735	COG2137	regulation of response to DNA damage stimulus
IXO220_008740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO220_008745	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO220_008770	COG0305	Participates in initiation and elongation during chromosome replication
IXO220_008775	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO220_008800	COG1741	Belongs to the pirin family
IXO220_008805	COG0583	DNA-binding transcription factor activity
IXO220_008835	COG0351	phosphomethylpyrimidine kinase
IXO220_008845	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO220_008850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO220_008870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO220_008880	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO220_008885	COG3734	2-keto-3-deoxy-galactonokinase
IXO220_008895	COG4948	Mandelate Racemase Muconate Lactonizing
IXO220_008900	COG0800	Aldolase
IXO220_008915	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO220_008925	COG1070	Carbohydrate kinase
IXO220_008935	COG0477	Major facilitator Superfamily
IXO220_008955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO220_009005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO220_009010	COG2258	MOSC domain
IXO220_009020	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO220_009025	COG0505	Belongs to the CarA family
IXO220_009035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO220_009040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO220_009050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO220_009115	COG0784	Response regulator, receiver
IXO220_009115	COG2198	Histidine kinase
IXO220_009115	COG2205	protein histidine kinase activity
IXO220_009120	COG1024	Enoyl-CoA hydratase
IXO220_009125	COG0318	PFAM AMP-dependent synthetase and ligase
IXO220_009155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO220_009185	COG0840	transmembrane signaling receptor activity
IXO220_009205	COG3039	Transposase
IXO220_009220	COG0835	chemotaxis
IXO220_009235	COG0840	transmembrane signaling receptor activity
IXO220_009240	COG0840	transmembrane signaling receptor activity
IXO220_009245	COG0840	transmembrane signaling receptor activity
IXO220_009250	COG0840	transmembrane signaling receptor activity
IXO220_009260	COG0840	transmembrane signaling receptor activity
IXO220_009270	COG0840	transmembrane signaling receptor activity
IXO220_009280	COG0840	transmembrane signaling receptor activity
IXO220_009300	COG0745	RESPONSE REGULATOR receiver
IXO220_009310	COG0835	chemotaxis
IXO220_009320	COG1360	Flagellar Motor Protein
IXO220_009325	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO220_009345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO220_009355	COG4771	TonB-dependent receptor
IXO220_009390	COG3039	Transposase
IXO220_009530	COG3039	Transposase
IXO220_009555	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO220_009575	COG3039	Transposase
IXO220_009585	COG3039	Transposase
IXO220_009600	COG3039	Transposase
IXO220_009610	COG3039	Transposase
IXO220_009625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO220_009625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO220_009630	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO220_009635	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO220_009635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO220_009640	COG1609	Transcriptional regulator
IXO220_009665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO220_009670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO220_009680	COG2902	Dehydrogenase
IXO220_009685	COG3039	Transposase
IXO220_009695	COG0784	Response regulator, receiver
IXO220_009695	COG2205	protein histidine kinase activity
IXO220_009695	COG5002	protein histidine kinase activity
IXO220_009700	COG2733	membrane
IXO220_009710	COG1121	(ABC) transporter
IXO220_009715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO220_009720	COG2223	nitrite transmembrane transporter activity
IXO220_009730	COG0243	molybdopterin cofactor binding
IXO220_009740	COG0477	Major facilitator Superfamily
IXO220_009750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO220_009755	COG0174	glutamine synthetase
IXO220_009760	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO220_009790	COG3842	ATPase activity
IXO220_009800	COG1177	transmembrane transport
IXO220_009810	COG1012	belongs to the aldehyde dehydrogenase family
IXO220_009825	COG4535	Mg2 and Co2 transporter CorC
IXO220_009845	COG1702	phosphate starvation-inducible protein PhoH
IXO220_009870	COG0741	lytic transglycosylase activity
IXO220_009875	COG0723	plastoquinol--plastocyanin reductase activity
IXO220_009880	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO220_009885	COG2857	Cytochrome c1
IXO220_009890	COG0625	glutathione transferase activity
IXO220_009895	COG2969	positive regulation of protein catabolic process
IXO220_009930	COG3328	transposase activity
IXO220_010005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO220_010025	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO220_010030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO220_010030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO220_010035	COG0802	atpase or kinase
IXO220_010040	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO220_010045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO220_010065	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_010075	COG0501	Belongs to the peptidase M48B family
IXO220_010085	COG2081	HI0933 family
IXO220_010090	COG4681	YaeQ
IXO220_010095	COG1671	Belongs to the UPF0178 family
IXO220_010105	COG0625	glutathione transferase activity
IXO220_010115	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IXO220_010120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO220_010125	COG0513	Belongs to the DEAD box helicase family
IXO220_010130	COG0488	(ABC) transporter
IXO220_010150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO220_010155	COG0483	inositol monophosphate 1-phosphatase activity
IXO220_010170	COG5001	Diguanylate cyclase
IXO220_010170	COG3300	MHYT domain
IXO220_010175	COG1509	lysine 2,3-aminomutase activity
IXO220_010190	COG0402	S-adenosylhomocysteine deaminase activity
IXO220_010195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO220_010220	COG4677	pectinesterase activity
IXO220_010245	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO220_010270	COG2166	iron-sulfur cluster assembly
IXO220_010285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO220_010290	COG0137	argininosuccinate synthase activity
IXO220_010300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO220_010305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO220_010320	COG0165	Argininosuccinate lyase
IXO220_010340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO220_010375	COG3039	Transposase
IXO220_010390	COG4988	ABC transporter
IXO220_010395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO220_010405	COG3039	Transposase
IXO220_010505	COG3039	Transposase
IXO220_010520	COG3209	COG3209 Rhs family protein
IXO220_010530	COG3039	Transposase
IXO220_010565	COG0643	Histidine kinase
IXO220_010565	COG2198	Histidine kinase
IXO220_010565	COG0784	Response regulator, receiver
IXO220_010620	COG1684	flagellar biosynthetic protein fliR
IXO220_010635	COG3190	flagellar
IXO220_010685	COG1677	Flagellar hook-basal body complex protein FliE
IXO220_010715	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_010725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO220_010745	COG2201	protein-glutamate methylesterase activity
IXO220_010775	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO220_010780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO220_010815	COG4787	bacterial-type flagellum-dependent cell motility
IXO220_010825	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO220_010830	COG1558	bacterial-type flagellum-dependent cell motility
IXO220_010840	COG0784	Response regulator, receiver
IXO220_010840	COG0835	chemotaxis
IXO220_010860	COG5002	protein histidine kinase activity
IXO220_010870	COG4585	Histidine kinase
IXO220_010875	COG5001	Diguanylate cyclase
IXO220_010900	COG0482	sulfurtransferase activity
IXO220_010915	COG0542	response to heat
IXO220_010940	COG0492	ferredoxin-NADP+ reductase activity
IXO220_010945	COG1674	ftsk spoiiie
IXO220_010965	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO220_010985	COG0038	chloride channel
IXO220_010990	COG0183	Belongs to the thiolase family
IXO220_010995	COG1024	Enoyl-CoA hydratase
IXO220_010995	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO220_011010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO220_011020	COG1426	Protein conserved in bacteria
IXO220_011030	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO220_011040	COG0303	'Molybdopterin
IXO220_011095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO220_011145	COG0742	ribosomal rna small subunit methyltransferase
IXO220_011150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO220_011165	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO220_011170	COG0405	Gamma-glutamyltransferase
IXO220_011195	COG3039	Transposase
IXO220_011275	COG0343	queuine tRNA-ribosyltransferase activity
IXO220_011280	COG1862	Preprotein translocase
IXO220_011285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO220_011290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO220_011330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO220_011340	COG0704	Plays a role in the regulation of phosphate uptake
IXO220_011355	COG0573	inorganic phosphate transmembrane transporter activity
IXO220_011360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO220_011405	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO220_011415	COG1024	Enoyl-CoA hydratase
IXO220_011430	COG0494	nUDIX hydrolase
IXO220_011475	COG0116	Belongs to the methyltransferase superfamily
IXO220_011475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO220_011500	COG0667	Aldo Keto reductase
IXO220_011510	COG2925	Exonuclease
IXO220_011545	COG0288	reversible hydration of carbon dioxide
IXO220_011575	COG0316	Belongs to the HesB IscA family
IXO220_011580	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO220_011590	COG0359	binds to the 23S rRNA
IXO220_011600	COG3115	cell septum assembly
IXO220_011620	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO220_011640	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO220_011665	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO220_011675	COG2986	histidine ammonia-lyase
IXO220_011680	COG1228	amidohydrolase
IXO220_011720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO220_011730	COG1605	Chorismate mutase
IXO220_011730	COG0077	Prephenate dehydratase
IXO220_011735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO220_011765	COG4566	intracellular signal transduction
IXO220_011810	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO220_011815	COG1469	GTP cyclohydrolase I activity
IXO220_011825	COG0617	tRNA 3'-terminal CCA addition
IXO220_011835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO220_011840	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO220_011870	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO220_011885	COG2203	Gaf domain
IXO220_011885	COG3706	GGDEF domain
IXO220_011885	COG4251	negative regulation of phosphorylation
IXO220_011885	COG5001	Diguanylate cyclase
IXO220_011945	COG1595	DNA-templated transcription, initiation
IXO220_011970	COG0386	Belongs to the glutathione peroxidase family
IXO220_012045	COG3039	Transposase
IXO220_012060	COG5002	protein histidine kinase activity
IXO220_012060	COG0784	Response regulator, receiver
IXO220_012060	COG2205	protein histidine kinase activity
IXO220_012100	COG0800	Aldolase
IXO220_012105	COG0129	dihydroxy-acid dehydratase activity
IXO220_012110	COG0363	glucosamine-6-phosphate deaminase activity
IXO220_012120	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO220_012135	COG0354	folic acid binding
IXO220_012150	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO220_012165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO220_012180	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO220_012205	COG0811	peptide transport
IXO220_012220	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO220_012230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO220_012240	COG0322	excinuclease ABC activity
IXO220_012275	COG3328	transposase activity
IXO220_012295	COG3039	Transposase
IXO220_012310	COG2801	Transposase and inactivated derivatives
IXO220_012320	COG2201	protein-glutamate methylesterase activity
IXO220_012370	COG0653	protein targeting
IXO220_012660	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO220_012660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO220_012670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO220_012680	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO220_012680	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO220_012695	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO220_012715	COG0124	histidyl-tRNA synthetase
IXO220_012730	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO220_012765	COG1012	belongs to the aldehyde dehydrogenase family
IXO220_012790	COG0697	spore germination
IXO220_012795	COG1794	racemase activity, acting on amino acids and derivatives
IXO220_012815	COG0671	phosphoesterase, PA-phosphatase related
IXO220_012830	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO220_012845	COG2183	response to ionizing radiation
IXO220_012855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO220_012855	COG0723	plastoquinol--plastocyanin reductase activity
IXO220_012870	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO220_012880	COG1183	phosphatidylcholine synthase activity
IXO220_012885	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_012910	COG0668	transmembrane transport
IXO220_012930	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO220_012980	COG0583	DNA-binding transcription factor activity
IXO220_012985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO220_012990	COG3002	Belongs to the UPF0753 family
IXO220_013005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO220_013025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO220_013035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO220_013040	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO220_013050	COG0776	regulation of translation
IXO220_013055	COG0539	negative regulation of cytoplasmic translation
IXO220_013060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO220_013075	COG2957	Belongs to the agmatine deiminase family
IXO220_013085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO220_013110	COG0395	ABC-type sugar transport system, permease component
IXO220_013115	COG1175	transmembrane transport
IXO220_013145	COG2350	Protein conserved in bacteria
IXO220_013150	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO220_013155	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO220_013160	COG1187	pseudouridine synthase activity
IXO220_013185	COG0436	Aminotransferase
IXO220_013250	COG0277	FAD linked oxidase domain protein
IXO220_013255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO220_013265	COG0531	amino acid
IXO220_013270	COG0531	amino acid
IXO220_013275	COG0235	Class ii aldolase
IXO220_013280	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO220_013310	COG2201	protein-glutamate methylesterase activity
IXO220_013360	COG0583	DNA-binding transcription factor activity
IXO220_013370	COG3039	Transposase
IXO220_013475	COG3039	Transposase
IXO220_013485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO220_013505	COG0557	exoribonuclease II activity
IXO220_013530	COG1960	acyl-CoA dehydrogenase activity
IXO220_013535	COG2226	methyltransferase
IXO220_013540	COG0646	methionine synthase
IXO220_013540	COG1410	methionine synthase
IXO220_013545	COG0646	methionine synthase
IXO220_013545	COG1410	methionine synthase
IXO220_013555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO220_013565	COG1609	Transcriptional regulator
IXO220_013580	COG2900	Belongs to the SlyX family
IXO220_013595	COG0386	Belongs to the glutathione peroxidase family
IXO220_013605	COG1725	Transcriptional regulator
IXO220_013610	COG1131	(ABC) transporter
IXO220_013670	COG2850	peptidyl-arginine hydroxylation
IXO220_013705	COG1132	(ABC) transporter
IXO220_013720	COG0583	DNA-binding transcription factor activity
IXO220_013735	COG1605	Chorismate mutase
IXO220_013735	COG0287	Prephenate dehydrogenase
IXO220_013740	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO220_013745	COG0484	heat shock protein binding
IXO220_013750	COG0443	Heat shock 70 kDa protein
IXO220_013755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO220_013765	COG0497	DNA recombination
IXO220_013775	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO220_013780	COG2914	Belongs to the UPF0125 (RnfH) family
IXO220_013790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO220_013805	COG1960	acyl-CoA dehydrogenase activity
IXO220_013815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO220_013870	COG2814	Major facilitator Superfamily
IXO220_013875	COG1566	PFAM secretion protein HlyD family protein
IXO220_013890	COG2207	Transcriptional regulator
IXO220_013915	COG4774	siderophore transport
IXO220_013925	COG0367	asparagine synthase
IXO220_013940	COG1393	Belongs to the ArsC family
IXO220_013955	COG3039	Transposase
IXO220_014005	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO220_014020	COG0233	cytoplasmic translational termination
IXO220_014030	COG0575	Belongs to the CDS family
IXO220_014040	COG0750	zinc metalloprotease
IXO220_014055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO220_014060	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO220_014080	COG0825	malonyl-CoA metabolic process
IXO220_014090	COG4771	TonB-dependent receptor
IXO220_014095	COG1131	(ABC) transporter
IXO220_014120	COG1981	membrane
IXO220_014165	COG2895	sulfate adenylyltransferase (ATP) activity
IXO220_014165	COG0529	Catalyzes the synthesis of activated sulfate
IXO220_014200	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO220_014215	COG2040	homocysteine
IXO220_014220	COG0833	amino acid
IXO220_014240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO220_014240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO220_014250	COG2878	Part of a membrane complex involved in electron transport
IXO220_014265	COG1595	DNA-templated transcription, initiation
IXO220_014290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO220_014305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO220_014310	COG0251	oxidation-reduction process
IXO220_014320	COG0392	lysyltransferase activity
IXO220_014320	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO220_014350	COG3039	Transposase
IXO220_014365	COG2814	Major facilitator Superfamily
IXO220_014370	COG1902	pentaerythritol trinitrate reductase activity
IXO220_014380	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO220_014395	COG1047	Peptidyl-prolyl cis-trans
IXO220_014435	COG3039	Transposase
IXO220_014440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO220_014455	COG1451	nucleotide metabolic process
IXO220_014475	COG0183	Belongs to the thiolase family
IXO220_014505	COG1793	dna ligase
IXO220_014505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO220_014515	COG1793	dna ligase
IXO220_014520	COG1201	RNA secondary structure unwinding
IXO220_014540	COG1278	Cold shock
IXO220_014545	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO220_014550	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO220_014560	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO220_014570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO220_014595	COG3039	Transposase
IXO220_014605	COG2954	triphosphatase activity
IXO220_014620	COG1381	Involved in DNA repair and RecF pathway recombination
IXO220_014650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO220_014665	COG1024	Enoyl-CoA hydratase
IXO220_014665	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO220_014685	COG1024	Enoyl-CoA hydratase
IXO220_014690	COG1960	acyl-CoA dehydrogenase activity
IXO220_014760	COG2353	YceI-like domain
IXO220_014770	COG2353	YceI-like domain
IXO220_014785	COG1760	l-serine dehydratase
IXO220_014795	COG0626	cystathionine gamma-synthase activity
IXO220_014800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO220_014805	COG0739	heme binding
IXO220_014815	COG1272	protein, Hemolysin III
IXO220_014835	COG0463	Glycosyl transferase, family 2
IXO220_014845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO220_014855	COG4771	TonB-dependent receptor
IXO220_014860	COG1309	transcriptional regulator
IXO220_014870	COG1960	acyl-CoA dehydrogenase activity
IXO220_014900	COG0509	glycine decarboxylation via glycine cleavage system
IXO220_014915	COG0330	HflC and HflK could
IXO220_014930	COG3956	TIGRFAM MazG family protein
IXO220_014940	COG0494	nUDIX hydrolase
IXO220_014950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO220_014955	COG0837	glucose binding
IXO220_014970	COG3858	chitin binding
IXO220_014970	COG1388	LysM domain
IXO220_014975	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO220_014985	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO220_015045	COG3537	Alpha-1,2-mannosidase
IXO220_015085	COG3142	Participates in the control of copper homeostasis
IXO220_015090	COG1446	asparaginase
IXO220_015115	COG3039	Transposase
IXO220_015135	COG2198	Histidine kinase
IXO220_015135	COG0784	Response regulator, receiver
IXO220_015135	COG0643	Histidine kinase
IXO220_015140	COG0840	transmembrane signaling receptor activity
IXO220_015145	COG0835	chemotaxis
IXO220_015160	COG0189	ligase activity
IXO220_015170	COG1397	ADP-ribosylglycohydrolase
IXO220_015180	COG1199	ATP-dependent helicase activity
IXO220_015190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO220_015195	COG1215	transferase activity, transferring glycosyl groups
IXO220_015205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO220_015225	COG0535	radical SAM domain protein
IXO220_015230	COG0535	radical SAM domain protein
IXO220_015255	COG1643	Atp-dependent helicase
IXO220_015260	COG0783	Belongs to the Dps family
IXO220_015265	COG0514	ATP-dependent DNA helicase (RecQ)
IXO220_015285	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO220_015335	COG1187	pseudouridine synthase activity
IXO220_015340	COG0602	queuosine metabolic process
IXO220_015350	COG2885	chlorophyll binding
IXO220_015365	COG0848	biopolymer transport protein
IXO220_015375	COG0824	Thioesterase
IXO220_015380	COG2255	four-way junction helicase activity
IXO220_015390	COG0632	four-way junction helicase activity
IXO220_015515	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO220_015520	COG1845	cytochrome c oxidase, subunit III
IXO220_015525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO220_015540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO220_015545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO220_015555	COG0196	riboflavin kinase activity
IXO220_015560	COG0728	peptidoglycan biosynthetic process
IXO220_015565	COG0268	Binds directly to 16S ribosomal RNA
IXO220_015570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO220_015575	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO220_015585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO220_015590	COG0824	Thioesterase
IXO220_015605	COG1946	Acyl-CoA thioesterase
IXO220_015615	COG1595	DNA-templated transcription, initiation
IXO220_015630	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO220_015665	COG1877	trehalose-phosphatase activity
IXO220_015670	COG3387	PFAM Glycoside hydrolase 15-related
IXO220_015695	COG0564	pseudouridine synthase activity
IXO220_015700	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO220_015705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO220_015705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO220_015715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO220_015720	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO220_015760	COG2194	sulfuric ester hydrolase activity
IXO220_015765	COG4969	Belongs to the N-Me-Phe pilin family
IXO220_015775	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO220_015795	COG3039	Transposase
IXO220_015815	COG3039	Transposase
IXO220_015850	COG1132	(ABC) transporter
IXO220_015880	COG0745	RESPONSE REGULATOR receiver
IXO220_015885	COG5000	phosphorelay sensor kinase activity
IXO220_015885	COG5002	protein histidine kinase activity
IXO220_015890	COG0475	glutathione-regulated potassium exporter activity
IXO220_015900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO220_015920	COG1187	pseudouridine synthase activity
IXO220_015925	COG5001	Diguanylate cyclase
IXO220_015925	COG5002	protein histidine kinase activity
IXO220_016030	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_016045	COG0415	Belongs to the DNA photolyase family
IXO220_016050	COG0305	Participates in initiation and elongation during chromosome replication
IXO220_016060	COG0367	asparagine synthase
IXO220_016075	COG1960	acyl-CoA dehydrogenase activity
IXO220_016090	COG0084	hydrolase, TatD family'
IXO220_016095	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO220_016155	COG0735	belongs to the Fur family
IXO220_016160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO220_016175	COG3039	Transposase
IXO220_016200	COG3039	Transposase
IXO220_016250	COG2205	protein histidine kinase activity
IXO220_016260	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO220_016270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO220_016285	COG2198	Histidine kinase
IXO220_016285	COG0643	Histidine kinase
IXO220_016290	COG0840	transmembrane signaling receptor activity
IXO220_016295	COG0835	chemotaxis
IXO220_016300	COG2199	diguanylate cyclase activity
IXO220_016300	COG2200	EAL domain
IXO220_016300	COG2202	Pas domain
IXO220_016305	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO220_016320	COG3590	peptidase
IXO220_016335	COG0588	phosphoglycerate mutase activity
IXO220_016340	COG1515	deoxyribonuclease V activity
IXO220_016350	COG1741	Belongs to the pirin family
IXO220_016415	COG1741	Belongs to the pirin family
IXO220_016420	COG1966	Carbon starvation protein
IXO220_016425	COG2879	small protein
IXO220_016465	COG5001	Diguanylate cyclase
IXO220_016465	COG4251	negative regulation of phosphorylation
IXO220_016465	COG3706	GGDEF domain
IXO220_016465	COG2203	Gaf domain
IXO220_016470	COG0629	single-stranded DNA binding
IXO220_016475	COG0142	geranyltranstransferase activity
IXO220_016500	COG0527	aspartate kinase activity
IXO220_016510	COG0384	phenazine biosynthesis protein PhzF
IXO220_016520	COG1764	response to oxidative stress
IXO220_016535	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO220_016540	COG1678	Uncharacterized ACR, COG1678
IXO220_016550	COG0519	Catalyzes the synthesis of GMP from XMP
IXO220_016580	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO220_016620	COG0693	protein deglycase activity
IXO220_016640	COG1959	2 iron, 2 sulfur cluster binding
IXO220_016645	COG0719	Fe-S assembly protein
IXO220_016650	COG0396	ATPase activity
IXO220_016655	COG0719	Fe-S assembly protein
IXO220_016660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO220_016670	COG2146	nitrite reductase [NAD(P)H] activity
IXO220_016695	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO220_016710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO220_016720	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO220_016725	COG0174	glutamine synthetase
IXO220_016730	COG3328	transposase activity
IXO220_016755	COG0326	Molecular chaperone. Has ATPase activity
IXO220_016760	COG2207	Transcriptional regulator
IXO220_016785	COG0657	acetylesterase activity
IXO220_016785	COG2755	lipolytic protein G-D-S-L family
IXO220_016810	COG0488	(ABC) transporter
IXO220_016845	COG4651	solute:proton antiporter activity
IXO220_016845	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO220_016865	COG4772	TonB-dependent receptor
IXO220_016875	COG4264	IucA IucC family
IXO220_016880	COG2814	Major facilitator Superfamily
IXO220_016890	COG0019	diaminopimelate decarboxylase activity
IXO220_016950	COG4206	TonB-dependent receptor
IXO220_016985	COG0542	response to heat
IXO220_017025	COG0534	Mate efflux family protein
IXO220_017045	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO220_017050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO220_017055	COG0228	four-way junction DNA binding
IXO220_017075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO220_017085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO220_017130	COG1555	photosystem II stabilization
IXO220_017135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO220_017150	COG3178	'Phosphotransferase
IXO220_017155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO220_017165	COG0628	permease
IXO220_017175	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO220_017190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO220_017210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO220_017215	COG0271	Belongs to the BolA IbaG family
IXO220_017225	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO220_017235	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO220_017240	COG1137	ATPase activity
IXO220_017255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO220_017260	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO220_017265	COG1660	Displays ATPase and GTPase activities
IXO220_017280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO220_017285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO220_017290	COG2239	Acts as a magnesium transporter
IXO220_017300	COG1294	oxidase, subunit
IXO220_017305	COG1271	oxidase subunit
IXO220_017320	COG1113	amino acid transport
IXO220_017335	COG2197	response regulator
IXO220_017340	COG0531	amino acid
IXO220_017395	COG0754	glutathionylspermidine amidase activity
IXO220_017420	COG1842	Phage shock protein A
IXO220_017435	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO220_017440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXO220_017450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO220_017485	COG2201	protein-glutamate methylesterase activity
IXO220_017525	COG2801	Transposase and inactivated derivatives
IXO220_017540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO220_017590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO220_017595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO220_017620	COG3039	Transposase
IXO220_017635	COG0745	RESPONSE REGULATOR receiver
IXO220_017640	COG2205	protein histidine kinase activity
IXO220_017660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO220_017690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO220_017690	COG3453	Protein conserved in bacteria
IXO220_017695	COG3039	Transposase
IXO220_017700	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO220_017705	COG4149	molybdate abc transporter
IXO220_017710	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO220_017730	COG0642	Histidine kinase
IXO220_017745	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_017755	COG1022	Amp-dependent synthetase and ligase
IXO220_017780	COG1376	ErfK ybiS ycfS ynhG family protein
IXO220_017785	COG0739	heme binding
IXO220_017795	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO220_017800	COG1301	dicarboxylic acid transport
IXO220_017820	COG2304	oxidoreductase activity
IXO220_017840	COG0714	Associated with various cellular activities
IXO220_017885	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO220_017910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO220_017920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO220_017945	COG1561	YicC-like family, N-terminal region
IXO220_017950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO220_017965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO220_018000	COG0006	proline dipeptidase activity
IXO220_018025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO220_018035	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO220_018045	COG2912	Transglutaminase-like superfamily
IXO220_018050	COG1773	rubredoxin
IXO220_018055	COG0352	thiamine-phosphate diphosphorylase activity
IXO220_018120	COG0281	malic enzyme
IXO220_018120	COG0280	phosphate acetyltransferase
IXO220_018140	COG4191	Histidine kinase
IXO220_018155	COG0583	DNA-binding transcription factor activity
IXO220_018170	COG2197	response regulator
IXO220_018180	COG0642	Histidine kinase
IXO220_018200	COG2851	Citrate transporter
IXO220_018205	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_018210	COG1609	Transcriptional regulator
IXO220_018220	COG2211	Major facilitator Superfamily
IXO220_018245	COG1162	GTPase activity
IXO220_018270	COG0726	polysaccharide deacetylase
IXO220_018275	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO220_018300	COG3039	Transposase
IXO220_018305	COG3039	Transposase
IXO220_018350	COG0242	peptide deformylase activity
IXO220_018370	COG0714	Associated with various cellular activities
IXO220_018390	COG0537	adenosine 5'-monophosphoramidase activity
IXO220_018420	COG0314	molybdopterin synthase activity
IXO220_018425	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO220_018430	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO220_018440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO220_018445	COG1234	tRNA 3'-trailer cleavage
IXO220_018450	COG3642	lipopolysaccharide core region biosynthetic process
IXO220_018455	COG0859	PFAM glycosyl transferase family 9
IXO220_018465	COG0582	viral genome integration into host DNA
IXO220_018520	COG0631	protein serine/threonine phosphatase activity
IXO220_018530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO220_018555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO220_018595	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO220_018645	COG0473	3-isopropylmalate dehydrogenase activity
IXO220_018670	COG4783	chaperone-mediated protein folding
IXO220_018685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO220_018695	COG0438	transferase activity, transferring glycosyl groups
IXO220_018700	COG0671	phosphoesterase, PA-phosphatase related
IXO220_018705	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO220_018725	COG2833	Protein of unknown function (DUF455)
IXO220_018745	COG0285	dihydrofolate synthase activity
IXO220_018755	COG0588	phosphoglycerate mutase activity
IXO220_018785	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO220_018790	COG4208	sulfate ABC transporter
IXO220_018795	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO220_018800	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO220_018805	COG0156	8-amino-7-oxononanoate synthase activity
IXO220_018830	COG0604	alcohol dehydrogenase
IXO220_018835	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO220_018835	COG1902	pentaerythritol trinitrate reductase activity
IXO220_018955	COG3386	PFAM SMP-30 Gluconolaconase
IXO220_018975	COG1024	Enoyl-CoA hydratase
IXO220_018985	COG0318	PFAM AMP-dependent synthetase and ligase
IXO220_018990	COG0583	DNA-binding transcription factor activity
IXO220_019030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO220_019035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO220_019045	COG2096	Adenosyltransferase
IXO220_019050	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO220_019065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO220_019075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO220_019080	COG2967	ApaG domain
IXO220_019105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO220_019125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO220_019150	COG0642	Histidine kinase
IXO220_019165	COG4181	ATPase activity
IXO220_019175	COG2175	clavaminate synthase activity
IXO220_019230	COG0667	Aldo Keto reductase
IXO220_019240	COG3039	Transposase
IXO220_019250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO220_019255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO220_019265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO220_019280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO220_019325	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO220_019330	COG2226	methyltransferase
IXO220_019375	COG3321	synthase
IXO220_019375	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_019375	COG0604	alcohol dehydrogenase
IXO220_019385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO220_019400	COG0494	nUDIX hydrolase
IXO220_019415	COG4942	peptidase
IXO220_019415	COG1388	LysM domain
IXO220_019425	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO220_019440	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO220_019445	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO220_019450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO220_019465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO220_019470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO220_019485	COG3116	cell division
IXO220_019490	COG0275	rRNA processing
IXO220_019525	COG0792	nuclease activity
IXO220_019530	COG1988	membrane-bound metal-dependent
IXO220_019535	COG0277	FAD linked oxidase domain protein
IXO220_019540	COG0745	RESPONSE REGULATOR receiver
IXO220_019545	COG2205	protein histidine kinase activity
IXO220_019555	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO220_019560	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO220_019580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO220_019585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO220_019590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO220_019610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO220_019610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO220_019630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO220_019650	COG0488	(ABC) transporter
IXO220_019660	COG3039	Transposase
IXO220_019705	COG2205	protein histidine kinase activity
IXO220_019750	COG2205	protein histidine kinase activity
IXO220_019765	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO220_019800	COG3039	Transposase
IXO220_019820	COG3039	Transposase
IXO220_019900	COG1649	PFAM Uncharacterised BCR, COG1649
IXO220_019900	COG0726	polysaccharide deacetylase
IXO220_019905	COG1215	transferase activity, transferring glycosyl groups
IXO220_019915	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO220_019920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO220_019925	COG1609	Transcriptional regulator
IXO220_019935	COG2188	Transcriptional regulator
IXO220_019950	COG3250	beta-galactosidase activity
IXO220_020000	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO220_020005	COG4191	Histidine kinase
IXO220_020010	COG0784	Response regulator, receiver
IXO220_020015	COG4251	negative regulation of phosphorylation
IXO220_020020	COG2823	Periplasmic or secreted lipoprotein
IXO220_020025	COG0673	inositol 2-dehydrogenase activity
IXO220_020030	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO220_020065	COG1056	cytidyltransferase-related domain
IXO220_020065	COG1051	belongs to the nudix hydrolase family
IXO220_020090	COG2921	Belongs to the UPF0250 family
IXO220_020105	COG1686	Belongs to the peptidase S11 family
IXO220_020110	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO220_020115	COG2951	lytic endotransglycosylase activity
IXO220_020185	COG0772	Belongs to the SEDS family
IXO220_020200	COG1792	Involved in formation and maintenance of cell shape
IXO220_020205	COG1077	Cell shape determining protein MreB Mrl
IXO220_020210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO220_020260	COG2199	diguanylate cyclase activity
IXO220_020265	COG0308	aminopeptidase N
IXO220_020295	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO220_020325	COG0436	Aminotransferase
IXO220_020350	COG1505	serine-type exopeptidase activity
IXO220_020375	COG0181	hydroxymethylbilane synthase activity
IXO220_020385	COG3275	phosphorelay sensor kinase activity
IXO220_020420	COG0659	secondary active sulfate transmembrane transporter activity
IXO220_020425	COG5297	Belongs to the glycosyl hydrolase family 6
IXO220_020425	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO220_020500	COG0598	Magnesium transport protein CorA
IXO220_020510	COG1113	amino acid transport
IXO220_020520	COG5297	Belongs to the glycosyl hydrolase family 6
IXO220_020525	COG4305	rare lipoprotein A
IXO220_020530	COG0697	spore germination
IXO220_020590	COG4221	oxidoreductase activity
IXO220_020620	COG0456	acetyltransferase
IXO220_020630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO220_020675	COG2111	Na H antiporter
IXO220_020675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO220_020680	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO220_020685	COG0651	ATP synthesis coupled electron transport
IXO220_020695	COG2212	antiporter activity
IXO220_020700	COG1320	monovalent cation:proton antiporter activity
IXO220_020710	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO220_020730	COG3104	oligopeptide transport
IXO220_020735	COG3483	tryptophan 2,3-dioxygenase activity
IXO220_020745	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IXO220_020785	COG0183	Belongs to the thiolase family
IXO220_020855	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO220_020860	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO220_020870	COG4948	Mandelate Racemase Muconate Lactonizing
IXO220_020895	COG0531	amino acid
IXO220_020925	COG4682	membrane
IXO220_020930	COG2133	pyrroloquinoline quinone binding
IXO220_020970	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO220_020975	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO220_020985	COG1610	YqeY-like protein
IXO220_020995	COG1295	ribonuclease BN
IXO220_021000	COG0358	DNA primase activity
IXO220_021065	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO220_021080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO220_021130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO220_021135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO220_021140	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO220_021150	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO220_021155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO220_021165	COG0134	indole-3-glycerol-phosphate synthase activity
IXO220_021170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO220_021245	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO220_021245	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO220_021255	COG1473	amidohydrolase
IXO220_021260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO220_021265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO220_021275	COG5383	Protein conserved in bacteria
IXO220_021310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO220_021315	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO220_021330	COG0028	Belongs to the TPP enzyme family
IXO220_021335	COG4191	Histidine kinase
IXO220_021360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO220_021375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO220_021380	COG3177	Filamentation induced by cAMP protein fic
IXO220_021395	COG0596	Alpha beta hydrolase
IXO220_021400	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO220_021405	COG0318	PFAM AMP-dependent synthetase and ligase
IXO220_021410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO220_021460	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO220_021470	COG0129	dihydroxy-acid dehydratase activity
IXO220_021490	COG3039	Transposase
IXO220_021500	COG0408	coproporphyrinogen oxidase activity
IXO220_021540	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXO220_021600	COG2353	YceI-like domain
IXO220_021605	COG0778	Nitroreductase
IXO220_021640	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO220_021655	COG3386	PFAM SMP-30 Gluconolaconase
IXO220_021695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO220_021715	COG0459	protein refolding
IXO220_021740	COG1252	NADH dehydrogenase
IXO220_021750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO220_021755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO220_021760	COG2201	protein-glutamate methylesterase activity
IXO220_021765	COG2177	Part of the ABC transporter FtsEX involved in
IXO220_021770	COG2884	Cell division ATP-binding protein ftsE
IXO220_021780	COG3118	belongs to the thioredoxin family
IXO220_021785	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO220_021800	COG0729	surface antigen
IXO220_021805	COG2911	Protein conserved in bacteria
IXO220_021840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO220_021855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO220_021905	COG1733	regulation of RNA biosynthetic process
IXO220_021910	COG0702	epimerase
IXO220_021940	COG0583	DNA-binding transcription factor activity
IXO220_021945	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO220_021965	COG0745	RESPONSE REGULATOR receiver
IXO220_021995	COG1902	pentaerythritol trinitrate reductase activity
IXO220_022000	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO220_022010	COG2814	Major facilitator Superfamily
IXO220_022015	COG0583	DNA-binding transcription factor activity
IXO220_022030	COG0084	hydrolase, TatD family'
IXO220_022075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO220_022095	COG2072	flavoprotein involved in K transport
IXO220_022155	COG4770	biotin carboxylase activity
IXO220_022160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO220_022165	COG1960	acyl-CoA dehydrogenase activity
IXO220_022215	COG0523	cobalamin synthesis protein
IXO220_022225	COG0697	spore germination
IXO220_022235	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO220_022250	COG4771	TonB-dependent receptor
IXO220_022255	COG0457	Tetratricopeptide repeat
IXO220_022265	COG0752	glycyl-tRNA synthetase alpha subunit
IXO220_022270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO220_022285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO220_022285	COG0519	Catalyzes the synthesis of GMP from XMP
IXO220_022295	COG0805	protein transport
IXO220_022305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO220_022315	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO220_022340	COG2974	May be involved in recombination
IXO220_022345	COG0037	tRNA processing
IXO220_022360	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO220_022370	COG4948	Mandelate Racemase Muconate Lactonizing
IXO220_022380	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO220_022385	COG0246	Mannitol dehydrogenase
IXO220_022410	COG3693	PFAM glycoside hydrolase, family 10
IXO220_022430	COG2211	Major facilitator Superfamily
IXO220_022475	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IXO220_022515	COG1846	Transcriptional regulator
IXO220_022520	COG1764	response to oxidative stress
IXO220_022595	COG3549	Plasmid maintenance system killer
IXO220_022605	COG1074	ATP-dependent DNA helicase activity
IXO220_022610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO220_022655	COG2032	superoxide dismutase activity
IXO220_022660	COG2032	superoxide dismutase activity
IXO220_022665	COG2204	response regulator
IXO220_022670	COG3852	Histidine kinase
IXO220_022675	COG0004	ammonium transporteR
IXO220_022680	COG0347	Belongs to the P(II) protein family
IXO220_022685	COG0174	glutamine synthetase
IXO220_022690	COG1968	undecaprenyl-diphosphatase activity
IXO220_022735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO220_022745	COG2062	phosphohistidine phosphatase, SixA
IXO220_022750	COG0489	protein tyrosine kinase activity
IXO220_022770	COG1396	sequence-specific DNA binding
IXO220_022775	COG3550	peptidyl-serine autophosphorylation
IXO220_022780	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO220_022785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO220_022800	COG0517	IMP dehydrogenase activity
IXO220_022800	COG1125	glycine betaine transport
IXO220_022815	COG1119	ATPase activity
IXO220_022825	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO220_022840	COG3039	Transposase
IXO220_022865	COG0656	L-ascorbic acid biosynthetic process
IXO220_022870	COG2130	NADP-dependent
IXO220_022875	COG0667	Aldo Keto reductase
IXO220_022885	COG1187	pseudouridine synthase activity
IXO220_022895	COG1643	Atp-dependent helicase
IXO220_022900	COG4807	Protein conserved in bacteria
IXO220_022905	COG4948	Mandelate Racemase Muconate Lactonizing
IXO220_022910	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO220_022915	COG1028	Short-chain dehydrogenase reductase Sdr
IXO220_022935	COG3507	Belongs to the glycosyl hydrolase 43 family
IXO220_022975	COG3162	membrane
IXO220_022980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO220_022995	COG0708	Exodeoxyribonuclease III
IXO220_023010	COG2091	lysine biosynthetic process via aminoadipic acid
IXO220_023020	COG3540	Alkaline phosphatase
IXO220_023025	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO220_023050	COG2159	amidohydrolase
IXO220_023060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO220_023065	COG0583	DNA-binding transcription factor activity
IXO220_023070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO220_023085	COG0210	DNA helicase
IXO220_023100	COG0531	amino acid
IXO220_023105	COG1322	Protein conserved in bacteria
IXO220_023115	COG0386	Belongs to the glutathione peroxidase family
IXO220_023170	COG0793	Belongs to the peptidase S41A family
IXO220_023175	COG4942	peptidase
IXO220_023185	COG2234	aminopeptidase activity
IXO220_023230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO220_023235	COG0302	gtp cyclohydrolase
IXO220_023255	COG0477	Major facilitator Superfamily
IXO220_023270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO220_023330	COG1929	Belongs to the glycerate kinase type-1 family
IXO220_023335	COG2271	Major facilitator Superfamily
IXO220_023350	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO220_023355	COG0861	Integral membrane protein TerC family
IXO220_023370	COG0584	glycerophosphoryl diester phosphodiesterase
IXO220_023380	COG0671	phosphoesterase, PA-phosphatase related
IXO220_023385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IXO220_023390	COG0726	polysaccharide deacetylase