locus-tag	class	description
IXO35_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO35_000020	COG0187	DNA topoisomerase II activity
IXO35_000030	COG0501	Belongs to the peptidase M48B family
IXO35_000060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO35_000070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO35_000080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO35_000090	COG4772	TonB-dependent receptor
IXO35_000105	COG3039	Transposase
IXO35_000110	COG1304	FMN binding
IXO35_000130	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO35_000145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO35_000215	COG3039	Transposase
IXO35_000230	COG2826	transposase and inactivated derivatives, IS30 family
IXO35_000255	COG3039	Transposase
IXO35_000265	COG1090	epimerase
IXO35_000275	COG0642	Histidine kinase
IXO35_000285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO35_000390	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO35_000465	COG3264	Mechanosensitive ion channel
IXO35_000465	COG1511	domain protein
IXO35_000480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO35_000485	COG2354	Protein conserved in bacteria
IXO35_000490	COG1649	PFAM Uncharacterised BCR, COG1649
IXO35_000510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO35_000535	COG0702	epimerase
IXO35_000550	COG1858	cytochrome C peroxidase
IXO35_000625	COG0513	Belongs to the DEAD box helicase family
IXO35_000630	COG3039	Transposase
IXO35_000675	COG1136	(ABC) transporter
IXO35_000705	COG1136	(ABC) transporter
IXO35_000750	COG1272	protein, Hemolysin III
IXO35_000755	COG1205	dead DEAH box helicase
IXO35_000755	COG1111	helicase
IXO35_000815	COG0070	glutamate synthase
IXO35_000815	COG0067	glutamate synthase
IXO35_000815	COG0069	glutamate synthase activity
IXO35_000820	COG0493	'glutamate synthase
IXO35_000860	COG1609	Transcriptional regulator
IXO35_000890	COG0366	Alpha amylase catalytic
IXO35_000895	COG0366	Alpha amylase catalytic
IXO35_000940	COG0606	chelatase, subunit chli
IXO35_000980	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO35_000985	COG1166	arginine decarboxylase activity
IXO35_001050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO35_001075	COG1028	Short-chain dehydrogenase reductase Sdr
IXO35_001100	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO35_001120	COG0210	DNA helicase
IXO35_001135	COG3132	Protein of unknown function, DUF480
IXO35_001140	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO35_001145	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO35_001180	COG2937	Belongs to the GPAT DAPAT family
IXO35_001210	COG2755	lipolytic protein G-D-S-L family
IXO35_001225	COG3186	Phenylalanine-4-hydroxylase
IXO35_001230	COG1522	sequence-specific DNA binding
IXO35_001275	COG1064	alcohol dehydrogenase
IXO35_001280	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO35_001290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO35_001300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO35_001320	COG0676	glucose-6-phosphate 1-epimerase activity
IXO35_001385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO35_001410	COG2853	Lipoprotein
IXO35_001425	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO35_001430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO35_001435	COG1127	ABC transporter
IXO35_001510	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO35_001520	COG3039	Transposase
IXO35_001525	COG3265	gluconokinase activity
IXO35_001530	COG2211	Major facilitator Superfamily
IXO35_001535	COG3459	Glycosyltransferase 36 associated
IXO35_001545	COG2205	protein histidine kinase activity
IXO35_001560	COG1414	Transcriptional regulator
IXO35_001565	COG0738	Major facilitator superfamily
IXO35_001570	COG3254	rhamnose metabolic process
IXO35_001600	COG0339	signal peptide processing
IXO35_001630	COG0564	pseudouridine synthase activity
IXO35_001640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO35_001650	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO35_001720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO35_001730	COG0842	Transport permease protein
IXO35_001735	COG1131	(ABC) transporter
IXO35_001765	COG1476	TRANSCRIPTIONal
IXO35_001775	COG4555	ABC transporter
IXO35_001810	COG0625	glutathione transferase activity
IXO35_001855	COG0583	DNA-binding transcription factor activity
IXO35_001895	COG1199	ATP-dependent helicase activity
IXO35_001915	COG1566	PFAM secretion protein HlyD family protein
IXO35_001940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO35_001980	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO35_001980	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO35_001985	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO35_002000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO35_002035	COG3237	CsbD-like
IXO35_002040	COG0180	Tryptophanyl-tRNA synthetase
IXO35_002045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO35_002090	COG0753	catalase activity
IXO35_002105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO35_002115	COG0628	permease
IXO35_002125	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO35_002130	COG1040	competence protein
IXO35_002135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO35_002140	COG0156	8-amino-7-oxononanoate synthase activity
IXO35_002150	COG1028	Short-chain dehydrogenase reductase Sdr
IXO35_002165	COG0463	Glycosyl transferase, family 2
IXO35_002175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO35_002180	COG3100	YcgL domain-containing protein
IXO35_002200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO35_002215	COG2239	Acts as a magnesium transporter
IXO35_002230	COG1042	CoA-binding domain protein
IXO35_002230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO35_002230	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO35_002240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO35_002245	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO35_002280	COG3485	protocatechuate 3,4-dioxygenase
IXO35_002300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO35_002305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO35_002330	COG4221	oxidoreductase activity
IXO35_002355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO35_002380	COG0463	Glycosyl transferase, family 2
IXO35_002395	COG1475	DNA binding
IXO35_002400	COG1192	Involved in chromosome partitioning
IXO35_002415	COG0708	Exodeoxyribonuclease III
IXO35_002420	COG2211	Major facilitator Superfamily
IXO35_002435	COG0739	heme binding
IXO35_002480	COG0745	RESPONSE REGULATOR receiver
IXO35_002520	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO35_002535	COG2814	Major facilitator Superfamily
IXO35_002550	COG1289	transmembrane transporter activity
IXO35_002575	COG0151	Belongs to the GarS family
IXO35_002585	COG0138	bifunctional purine biosynthesis protein purh
IXO35_002595	COG2267	carboxylic ester hydrolase activity
IXO35_002600	COG2267	carboxylic ester hydrolase activity
IXO35_002605	COG2267	carboxylic ester hydrolase activity
IXO35_002625	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO35_002670	COG0439	Biotin carboxylase
IXO35_002680	COG0511	ligase activity, forming carbon-carbon bonds
IXO35_002685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO35_002695	COG1324	tolerance protein
IXO35_002730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO35_002755	COG0534	Mate efflux family protein
IXO35_002760	COG0616	signal peptide processing
IXO35_002770	COG1028	Short-chain dehydrogenase reductase Sdr
IXO35_002785	COG0009	L-threonylcarbamoyladenylate synthase
IXO35_002790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO35_002790	COG1754	DNA topoisomerase type I activity
IXO35_002805	COG2922	Belongs to the Smg family
IXO35_002810	COG0758	DNA mediated transformation
IXO35_002815	COG1652	LysM domain
IXO35_002820	COG0242	peptide deformylase activity
IXO35_002825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO35_002890	COG1560	Kdo2-lipid A biosynthetic process
IXO35_002900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO35_003055	COG3039	Transposase
IXO35_003065	COG1271	oxidase subunit
IXO35_003115	COG2972	Histidine kinase
IXO35_003130	COG0531	amino acid
IXO35_003150	COG3590	peptidase
IXO35_003160	COG0667	Aldo Keto reductase
IXO35_003175	COG3384	dioxygenase
IXO35_003185	COG1573	uracil-dna glycosylase
IXO35_003195	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO35_003205	COG0025	NhaP-type Na H and K H
IXO35_003210	COG1131	(ABC) transporter
IXO35_003215	COG0842	Transport permease protein
IXO35_003230	COG1404	Belongs to the peptidase S8 family
IXO35_003245	COG0745	RESPONSE REGULATOR receiver
IXO35_003295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO35_003320	COG2202	Pas domain
IXO35_003320	COG2205	protein histidine kinase activity
IXO35_003350	COG2813	Specifically methylates the guanine in position
IXO35_003355	COG1187	pseudouridine synthase activity
IXO35_003360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO35_003400	COG0697	spore germination
IXO35_003410	COG2011	ABC-type metal ion transport system permease component
IXO35_003440	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO35_003450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO35_003470	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO35_003480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO35_003490	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO35_003495	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO35_003500	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO35_003505	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXO35_003555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO35_003560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO35_003610	COG0339	signal peptide processing
IXO35_003650	COG1956	GAF domain-containing protein
IXO35_003655	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO35_003665	COG0720	synthase
IXO35_003670	COG0513	Belongs to the DEAD box helicase family
IXO35_003685	COG0625	glutathione transferase activity
IXO35_003715	COG0626	cystathionine gamma-synthase activity
IXO35_003755	COG3328	transposase activity
IXO35_003780	COG2086	electron transfer activity
IXO35_003805	COG0662	Cupin 2, conserved barrel domain protein
IXO35_003805	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO35_003810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO35_003845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO35_003845	COG3218	ABC-type transport auxiliary lipoprotein component
IXO35_003850	COG1127	ABC transporter
IXO35_003855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO35_003875	COG0442	prolyl-tRNA aminoacylation
IXO35_003885	COG1183	phosphatidylcholine synthase activity
IXO35_003915	COG3039	Transposase
IXO35_003950	COG3039	Transposase
IXO35_003980	COG0525	valine-tRNA ligase activity
IXO35_003995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO35_004005	COG0795	lipopolysaccharide-transporting ATPase activity
IXO35_004020	COG4974	Belongs to the 'phage' integrase family
IXO35_004025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO35_004030	COG0047	phosphoribosylformylglycinamidine synthase activity
IXO35_004030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXO35_004035	COG5295	Hep Hag repeat protein
IXO35_004045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO35_004055	COG1459	type II secretion system
IXO35_004060	COG2165	general secretion pathway protein
IXO35_004065	COG4970	Tfp pilus assembly protein FimT
IXO35_004070	COG2165	general secretion pathway protein
IXO35_004075	COG4795	General secretion pathway protein
IXO35_004080	COG3156	type II secretion system protein K
IXO35_004085	COG3166	PFAM Fimbrial assembly family protein
IXO35_004100	COG1450	Type ii and iii secretion system protein
IXO35_004115	COG2188	Transcriptional regulator
IXO35_004155	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO35_004160	COG1518	maintenance of DNA repeat elements
IXO35_004195	COG3039	Transposase
IXO35_004215	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO35_004240	COG1028	Short-chain dehydrogenase reductase Sdr
IXO35_004245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO35_004255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO35_004260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO35_004280	COG3039	Transposase
IXO35_004300	COG3829	transcription factor binding
IXO35_004380	COG2826	transposase and inactivated derivatives, IS30 family
IXO35_004390	COG0678	peroxiredoxin activity
IXO35_004410	COG0330	HflC and HflK could
IXO35_004415	COG0330	HflC and HflK could
IXO35_004425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO35_004430	COG0308	aminopeptidase N
IXO35_004490	COG1560	Kdo2-lipid A biosynthetic process
IXO35_004495	COG1519	Transferase
IXO35_004500	COG1538	Outer membrane efflux protein
IXO35_004505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO35_004535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO35_004540	COG0066	3-isopropylmalate dehydratase activity
IXO35_004545	COG2226	methyltransferase
IXO35_004575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO35_004585	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO35_004590	COG3710	Transcriptional regulator
IXO35_004615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO35_004635	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO35_004670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO35_004680	COG3781	membrane
IXO35_004815	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO35_004835	COG1217	gtp-binding protein TYPA
IXO35_004840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO35_004845	COG0039	L-malate dehydrogenase activity
IXO35_004850	COG0625	glutathione transferase activity
IXO35_004865	COG3039	Transposase
IXO35_004900	COG0584	glycerophosphoryl diester phosphodiesterase
IXO35_004935	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO35_004965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO35_004970	COG0583	DNA-binding transcription factor activity
IXO35_004975	COG3634	alkyl hydroperoxide reductase activity
IXO35_004985	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO35_005025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO35_005025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO35_005040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO35_005065	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO35_005090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO35_005100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO35_005130	COG1295	ribonuclease BN
IXO35_005135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO35_005155	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO35_005165	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO35_005170	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO35_005180	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO35_005195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO35_005205	COG0193	aminoacyl-tRNA hydrolase activity
IXO35_005210	COG0012	GTP binding
IXO35_005240	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO35_005245	COG0250	Participates in transcription elongation, termination and antitermination
IXO35_005250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO35_005260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO35_005265	COG0222	ribosome binding
IXO35_005270	COG0085	RNA polymerase activity
IXO35_005275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO35_005280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO35_005285	COG0049	tRNA binding
IXO35_005305	COG0051	transcription antitermination factor activity, RNA binding
IXO35_005310	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO35_005315	COG0088	Forms part of the polypeptide exit tunnel
IXO35_005320	COG0089	rRNA binding
IXO35_005335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO35_005345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO35_005350	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO35_005355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO35_005360	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO35_005370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO35_005400	COG1841	ribosomal large subunit assembly
IXO35_005410	COG0201	protein transport
IXO35_005420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO35_005425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO35_005435	COG0203	ribosomal protein L17
IXO35_005495	COG3551	Protein conserved in bacteria
IXO35_005525	COG2194	sulfuric ester hydrolase activity
IXO35_005535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO35_005540	COG0745	RESPONSE REGULATOR receiver
IXO35_005545	COG0642	Histidine kinase
IXO35_005555	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO35_005560	COG2894	cell division
IXO35_005575	COG4585	Histidine kinase
IXO35_005580	COG2197	response regulator
IXO35_005595	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO35_005620	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IXO35_005625	COG2963	transposase activity
IXO35_005730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO35_005740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO35_005750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO35_005895	COG3039	Transposase
IXO35_005910	COG3039	Transposase
IXO35_005970	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO35_005990	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO35_005995	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO35_006000	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO35_006015	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO35_006085	COG0587	DNA-directed DNA polymerase activity
IXO35_006100	COG1297	OPT oligopeptide transporter protein
IXO35_006120	COG0823	Involved in the tonB-independent uptake of proteins
IXO35_006120	COG1506	peptidase
IXO35_006140	COG1917	Cupin 2, conserved barrel domain protein
IXO35_006140	COG2207	Transcriptional regulator
IXO35_006165	COG0753	catalase activity
IXO35_006205	COG0469	pyruvate kinase activity
IXO35_006210	COG3588	fructose-bisphosphate aldolase
IXO35_006215	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO35_006265	COG0784	Response regulator, receiver
IXO35_006265	COG2198	Histidine kinase
IXO35_006265	COG2205	protein histidine kinase activity
IXO35_006285	COG0175	sulfate reduction
IXO35_006290	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO35_006295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO35_006300	COG0175	sulfate reduction
IXO35_006305	COG0529	Catalyzes the synthesis of activated sulfate
IXO35_006305	COG2895	sulfate adenylyltransferase (ATP) activity
IXO35_006315	COG3039	Transposase
IXO35_006325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO35_006330	COG0308	aminopeptidase N
IXO35_006350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO35_006370	COG1970	mechanosensitive ion channel activity
IXO35_006400	COG0471	metal ion transport
IXO35_006400	COG3273	potassium ion transport
IXO35_006410	COG2022	thiamine diphosphate biosynthetic process
IXO35_006535	COG3118	belongs to the thioredoxin family
IXO35_006560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO35_006585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO35_006615	COG2968	Membrane
IXO35_006630	COG3164	Protein of unknown function
IXO35_006640	COG0312	modulator of DNA gyrase
IXO35_006645	COG3028	Belongs to the UPF0307 family
IXO35_006650	COG0312	modulator of DNA gyrase
IXO35_006685	COG0142	geranyltranstransferase activity
IXO35_006690	COG1722	exodeoxyribonuclease VII activity
IXO35_006695	COG0037	tRNA processing
IXO35_006700	COG1785	Belongs to the alkaline phosphatase family
IXO35_006705	COG1301	dicarboxylic acid transport
IXO35_006720	COG0791	NLP P60 protein
IXO35_006725	COG0791	NLP P60 protein
IXO35_006730	COG1047	Peptidyl-prolyl cis-trans
IXO35_006735	COG2311	Membrane
IXO35_006740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO35_006780	COG0489	protein tyrosine kinase activity
IXO35_006785	COG0717	Belongs to the dCTP deaminase family
IXO35_006805	COG0412	Dienelactone hydrolase
IXO35_006815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO35_006860	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO35_006865	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO35_006870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO35_006875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO35_006895	COG0101	tRNA pseudouridine synthase activity
IXO35_006900	COG0135	phosphoribosylanthranilate isomerase activity
IXO35_006920	COG0159	tryptophan synthase activity
IXO35_006925	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO35_006930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO35_006980	COG0149	triose-phosphate isomerase activity
IXO35_006995	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO35_007005	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO35_007010	COG0649	NAD binding
IXO35_007015	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO35_007020	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO35_007025	COG1034	ATP synthesis coupled electron transport
IXO35_007030	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO35_007060	COG1007	ATP synthesis coupled electron transport
IXO35_007070	COG0779	Required for maturation of 30S ribosomal subunits
IXO35_007075	COG0195	Participates in both transcription termination and antitermination
IXO35_007080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IXO35_007095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO35_007100	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO35_007135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO35_007145	COG2095	MarC family integral membrane protein
IXO35_007160	COG1611	Belongs to the LOG family
IXO35_007200	COG4969	Belongs to the N-Me-Phe pilin family
IXO35_007205	COG0556	nucleotide-excision repair
IXO35_007245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO35_007260	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO35_007315	COG0438	transferase activity, transferring glycosyl groups
IXO35_007320	COG0438	transferase activity, transferring glycosyl groups
IXO35_007330	COG0438	transferase activity, transferring glycosyl groups
IXO35_007375	COG3040	lipid binding
IXO35_007460	COG0784	Response regulator, receiver
IXO35_007460	COG4191	Histidine kinase
IXO35_007480	COG0552	protein localization to endoplasmic reticulum
IXO35_007490	COG3938	Belongs to the proline racemase family
IXO35_007495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO35_007510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO35_007520	COG0006	proline dipeptidase activity
IXO35_007535	COG0531	amino acid
IXO35_007585	COG4206	TonB-dependent receptor
IXO35_007610	COG3328	transposase activity
IXO35_007670	COG0746	molybdenum cofactor guanylyltransferase activity
IXO35_007695	COG1648	precorrin-2 dehydrogenase activity
IXO35_007695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO35_007730	COG3039	Transposase
IXO35_007735	COG3039	Transposase
IXO35_007765	COG3039	Transposase
IXO35_007780	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO35_007800	COG1054	Belongs to the UPF0176 family
IXO35_007815	COG1530	ribonuclease E activity
IXO35_007825	COG3064	Membrane
IXO35_007830	COG0428	transporter
IXO35_007835	COG0428	transporter
IXO35_007845	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO35_007850	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IXO35_007850	COG0316	Belongs to the HesB IscA family
IXO35_007895	COG3039	Transposase
IXO35_008025	COG0631	protein serine/threonine phosphatase activity
IXO35_008060	COG1858	cytochrome C peroxidase
IXO35_008115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO35_008120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO35_008140	COG2201	protein-glutamate methylesterase activity
IXO35_008185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO35_008205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO35_008220	COG1595	DNA-templated transcription, initiation
IXO35_008270	COG2244	polysaccharide biosynthetic process
IXO35_008300	COG2264	protein methyltransferase activity
IXO35_008310	COG0438	transferase activity, transferring glycosyl groups
IXO35_008325	COG1136	(ABC) transporter
IXO35_008330	COG1132	(ABC) transporter
IXO35_008340	COG0477	Major facilitator Superfamily
IXO35_008350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO35_008365	COG1253	flavin adenine dinucleotide binding
IXO35_008375	COG0306	phosphate transporter
IXO35_008405	COG0504	CTP synthase activity
IXO35_008410	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO35_008420	COG0148	phosphopyruvate hydratase activity
IXO35_008425	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO35_008430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO35_008440	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO35_008450	COG2840	Smr protein MutS2
IXO35_008455	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO35_008460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO35_008465	COG1238	metal cluster binding
IXO35_008480	COG1534	Rna-binding protein
IXO35_008485	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO35_008495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO35_008500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO35_008510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO35_008515	COG1546	Belongs to the CinA family
IXO35_008530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO35_008535	COG2137	regulation of response to DNA damage stimulus
IXO35_008540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO35_008545	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO35_008570	COG0305	Participates in initiation and elongation during chromosome replication
IXO35_008575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO35_008600	COG1741	Belongs to the pirin family
IXO35_008605	COG0583	DNA-binding transcription factor activity
IXO35_008635	COG0351	phosphomethylpyrimidine kinase
IXO35_008645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO35_008650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO35_008670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO35_008680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO35_008685	COG3734	2-keto-3-deoxy-galactonokinase
IXO35_008695	COG4948	Mandelate Racemase Muconate Lactonizing
IXO35_008700	COG0800	Aldolase
IXO35_008715	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO35_008725	COG1070	Carbohydrate kinase
IXO35_008735	COG0477	Major facilitator Superfamily
IXO35_008755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO35_008805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO35_008810	COG2258	MOSC domain
IXO35_008820	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO35_008825	COG0505	Belongs to the CarA family
IXO35_008835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO35_008840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO35_008850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO35_008920	COG2198	Histidine kinase
IXO35_008920	COG2205	protein histidine kinase activity
IXO35_008920	COG0784	Response regulator, receiver
IXO35_008925	COG1024	Enoyl-CoA hydratase
IXO35_008930	COG0318	PFAM AMP-dependent synthetase and ligase
IXO35_008960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO35_008990	COG0840	transmembrane signaling receptor activity
IXO35_009025	COG0835	chemotaxis
IXO35_009040	COG0840	transmembrane signaling receptor activity
IXO35_009045	COG0840	transmembrane signaling receptor activity
IXO35_009050	COG0840	transmembrane signaling receptor activity
IXO35_009055	COG0840	transmembrane signaling receptor activity
IXO35_009065	COG0840	transmembrane signaling receptor activity
IXO35_009075	COG0840	transmembrane signaling receptor activity
IXO35_009105	COG0745	RESPONSE REGULATOR receiver
IXO35_009115	COG0835	chemotaxis
IXO35_009125	COG1360	Flagellar Motor Protein
IXO35_009130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO35_009150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO35_009160	COG4771	TonB-dependent receptor
IXO35_009200	COG3039	Transposase
IXO35_009330	COG3039	Transposase
IXO35_009365	COG3039	Transposase
IXO35_009375	COG3039	Transposase
IXO35_009390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO35_009390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO35_009395	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO35_009400	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO35_009400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO35_009405	COG1609	Transcriptional regulator
IXO35_009430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO35_009435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO35_009445	COG2902	Dehydrogenase
IXO35_009450	COG3039	Transposase
IXO35_009460	COG0784	Response regulator, receiver
IXO35_009460	COG2205	protein histidine kinase activity
IXO35_009460	COG5002	protein histidine kinase activity
IXO35_009465	COG2733	membrane
IXO35_009475	COG1121	(ABC) transporter
IXO35_009480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO35_009490	COG2223	nitrite transmembrane transporter activity
IXO35_009500	COG0243	molybdopterin cofactor binding
IXO35_009510	COG0477	Major facilitator Superfamily
IXO35_009520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO35_009525	COG0174	glutamine synthetase
IXO35_009560	COG3842	ATPase activity
IXO35_009590	COG1012	belongs to the aldehyde dehydrogenase family
IXO35_009605	COG4535	Mg2 and Co2 transporter CorC
IXO35_009625	COG1702	phosphate starvation-inducible protein PhoH
IXO35_009650	COG0741	lytic transglycosylase activity
IXO35_009655	COG0723	plastoquinol--plastocyanin reductase activity
IXO35_009660	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO35_009665	COG2857	Cytochrome c1
IXO35_009670	COG0625	glutathione transferase activity
IXO35_009675	COG2969	positive regulation of protein catabolic process
IXO35_009710	COG3328	transposase activity
IXO35_009790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO35_009810	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO35_009815	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO35_009815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO35_009820	COG0802	atpase or kinase
IXO35_009825	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO35_009830	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO35_009850	COG1028	Short-chain dehydrogenase reductase Sdr
IXO35_009860	COG0501	Belongs to the peptidase M48B family
IXO35_009870	COG2081	HI0933 family
IXO35_009875	COG4681	YaeQ
IXO35_009880	COG1671	Belongs to the UPF0178 family
IXO35_009890	COG0625	glutathione transferase activity
IXO35_009900	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IXO35_009905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO35_009910	COG0513	Belongs to the DEAD box helicase family
IXO35_009915	COG0488	(ABC) transporter
IXO35_009935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO35_009940	COG0483	inositol monophosphate 1-phosphatase activity
IXO35_009955	COG5001	Diguanylate cyclase
IXO35_009955	COG3300	MHYT domain
IXO35_009960	COG1509	lysine 2,3-aminomutase activity
IXO35_009975	COG0402	S-adenosylhomocysteine deaminase activity
IXO35_009980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO35_010005	COG4677	pectinesterase activity
IXO35_010030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO35_010055	COG2166	iron-sulfur cluster assembly
IXO35_010070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO35_010075	COG0137	argininosuccinate synthase activity
IXO35_010085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO35_010090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO35_010105	COG0165	Argininosuccinate lyase
IXO35_010125	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO35_010160	COG3039	Transposase
IXO35_010175	COG4988	ABC transporter
IXO35_010180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO35_010190	COG3039	Transposase
IXO35_010285	COG3039	Transposase
IXO35_010300	COG3209	COG3209 Rhs family protein
IXO35_010310	COG3039	Transposase
IXO35_010345	COG2198	Histidine kinase
IXO35_010345	COG0784	Response regulator, receiver
IXO35_010345	COG0643	Histidine kinase
IXO35_010400	COG1684	flagellar biosynthetic protein fliR
IXO35_010415	COG3190	flagellar
IXO35_010465	COG1677	Flagellar hook-basal body complex protein FliE
IXO35_010500	COG1028	Short-chain dehydrogenase reductase Sdr
IXO35_010510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO35_010530	COG2201	protein-glutamate methylesterase activity
IXO35_010560	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO35_010565	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO35_010605	COG4787	bacterial-type flagellum-dependent cell motility
IXO35_010615	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO35_010620	COG1558	bacterial-type flagellum-dependent cell motility
IXO35_010630	COG0784	Response regulator, receiver
IXO35_010630	COG0835	chemotaxis
IXO35_010650	COG5002	protein histidine kinase activity
IXO35_010660	COG4585	Histidine kinase
IXO35_010665	COG5001	Diguanylate cyclase
IXO35_010690	COG0482	sulfurtransferase activity
IXO35_010710	COG0542	response to heat
IXO35_010735	COG0492	ferredoxin-NADP+ reductase activity
IXO35_010740	COG1674	ftsk spoiiie
IXO35_010760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO35_010780	COG0038	chloride channel
IXO35_010785	COG0183	Belongs to the thiolase family
IXO35_010790	COG1024	Enoyl-CoA hydratase
IXO35_010790	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO35_010805	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO35_010815	COG1426	Protein conserved in bacteria
IXO35_010825	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO35_010835	COG0303	'Molybdopterin
IXO35_010890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO35_010940	COG0742	ribosomal rna small subunit methyltransferase
IXO35_010945	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO35_010960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO35_010965	COG0405	Gamma-glutamyltransferase
IXO35_010990	COG3039	Transposase
IXO35_011060	COG0343	queuine tRNA-ribosyltransferase activity
IXO35_011065	COG1862	Preprotein translocase
IXO35_011070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO35_011075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO35_011115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO35_011125	COG0704	Plays a role in the regulation of phosphate uptake
IXO35_011140	COG0573	inorganic phosphate transmembrane transporter activity
IXO35_011145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO35_011190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO35_011200	COG1024	Enoyl-CoA hydratase
IXO35_011210	COG0494	nUDIX hydrolase
IXO35_011255	COG0116	Belongs to the methyltransferase superfamily
IXO35_011255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO35_011280	COG0667	Aldo Keto reductase
IXO35_011290	COG2925	Exonuclease
IXO35_011320	COG0288	reversible hydration of carbon dioxide
IXO35_011350	COG0316	Belongs to the HesB IscA family
IXO35_011355	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO35_011365	COG0359	binds to the 23S rRNA
IXO35_011375	COG3115	cell septum assembly
IXO35_011390	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO35_011410	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO35_011435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO35_011445	COG2986	histidine ammonia-lyase
IXO35_011450	COG1228	amidohydrolase
IXO35_011490	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO35_011500	COG0077	Prephenate dehydratase
IXO35_011500	COG1605	Chorismate mutase
IXO35_011505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO35_011535	COG4566	intracellular signal transduction
IXO35_011580	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO35_011585	COG1469	GTP cyclohydrolase I activity
IXO35_011595	COG0617	tRNA 3'-terminal CCA addition
IXO35_011605	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO35_011610	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO35_011640	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO35_011660	COG3706	GGDEF domain
IXO35_011660	COG2203	Gaf domain
IXO35_011660	COG4251	negative regulation of phosphorylation
IXO35_011660	COG5001	Diguanylate cyclase
IXO35_011720	COG1595	DNA-templated transcription, initiation
IXO35_011745	COG0386	Belongs to the glutathione peroxidase family
IXO35_011825	COG3039	Transposase
IXO35_011840	COG5002	protein histidine kinase activity
IXO35_011840	COG2205	protein histidine kinase activity
IXO35_011840	COG0784	Response regulator, receiver
IXO35_011880	COG0800	Aldolase
IXO35_011885	COG0129	dihydroxy-acid dehydratase activity
IXO35_011890	COG0363	glucosamine-6-phosphate deaminase activity
IXO35_011900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO35_011915	COG0354	folic acid binding
IXO35_011930	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO35_011945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO35_011960	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO35_011985	COG0811	peptide transport
IXO35_012000	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO35_012010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO35_012020	COG0322	excinuclease ABC activity
IXO35_012055	COG3328	transposase activity
IXO35_012075	COG3039	Transposase
IXO35_012090	COG2801	Transposase and inactivated derivatives
IXO35_012100	COG2201	protein-glutamate methylesterase activity
IXO35_012150	COG0653	protein targeting
IXO35_012380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO35_012380	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO35_012390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO35_012400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO35_012400	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO35_012415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO35_012435	COG0124	histidyl-tRNA synthetase
IXO35_012455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO35_012495	COG1012	belongs to the aldehyde dehydrogenase family
IXO35_012510	COG0167	dihydroorotate dehydrogenase activity
IXO35_012515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IXO35_012520	COG0697	spore germination
IXO35_012525	COG1794	racemase activity, acting on amino acids and derivatives
IXO35_012550	COG0671	phosphoesterase, PA-phosphatase related
IXO35_012565	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO35_012580	COG2183	response to ionizing radiation
IXO35_012590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO35_012590	COG0723	plastoquinol--plastocyanin reductase activity
IXO35_012605	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO35_012615	COG1183	phosphatidylcholine synthase activity
IXO35_012620	COG1028	Short-chain dehydrogenase reductase Sdr
IXO35_012645	COG0668	transmembrane transport
IXO35_012665	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO35_012715	COG0583	DNA-binding transcription factor activity
IXO35_012720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO35_012725	COG3002	Belongs to the UPF0753 family
IXO35_012740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO35_012760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO35_012770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO35_012775	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO35_012785	COG0776	regulation of translation
IXO35_012790	COG0539	negative regulation of cytoplasmic translation
IXO35_012795	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO35_012810	COG2957	Belongs to the agmatine deiminase family
IXO35_012820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO35_012845	COG0395	ABC-type sugar transport system, permease component
IXO35_012850	COG1175	transmembrane transport
IXO35_012880	COG2350	Protein conserved in bacteria
IXO35_012885	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO35_012890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO35_012895	COG1187	pseudouridine synthase activity
IXO35_012920	COG0436	Aminotransferase
IXO35_012985	COG0277	FAD linked oxidase domain protein
IXO35_012990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO35_013000	COG0531	amino acid
IXO35_013005	COG0531	amino acid
IXO35_013010	COG0235	Class ii aldolase
IXO35_013015	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO35_013045	COG2201	protein-glutamate methylesterase activity
IXO35_013095	COG0583	DNA-binding transcription factor activity
IXO35_013105	COG3039	Transposase
IXO35_013205	COG3039	Transposase
IXO35_013215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO35_013235	COG0557	exoribonuclease II activity
IXO35_013260	COG1960	acyl-CoA dehydrogenase activity
IXO35_013265	COG2226	methyltransferase
IXO35_013270	COG0646	methionine synthase
IXO35_013270	COG1410	methionine synthase
IXO35_013275	COG0646	methionine synthase
IXO35_013275	COG1410	methionine synthase
IXO35_013285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO35_013295	COG1609	Transcriptional regulator
IXO35_013310	COG2900	Belongs to the SlyX family
IXO35_013325	COG0386	Belongs to the glutathione peroxidase family
IXO35_013335	COG1725	Transcriptional regulator
IXO35_013340	COG1131	(ABC) transporter
IXO35_013405	COG2850	peptidyl-arginine hydroxylation
IXO35_013440	COG1132	(ABC) transporter
IXO35_013455	COG0583	DNA-binding transcription factor activity
IXO35_013470	COG0287	Prephenate dehydrogenase
IXO35_013470	COG1605	Chorismate mutase
IXO35_013475	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO35_013480	COG0484	heat shock protein binding
IXO35_013485	COG0443	Heat shock 70 kDa protein
IXO35_013490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO35_013500	COG0497	DNA recombination
IXO35_013510	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO35_013515	COG2914	Belongs to the UPF0125 (RnfH) family
IXO35_013525	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO35_013540	COG1960	acyl-CoA dehydrogenase activity
IXO35_013550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO35_013605	COG2814	Major facilitator Superfamily
IXO35_013610	COG1566	PFAM secretion protein HlyD family protein
IXO35_013625	COG2207	Transcriptional regulator
IXO35_013650	COG4774	siderophore transport
IXO35_013660	COG0367	asparagine synthase
IXO35_013675	COG1393	Belongs to the ArsC family
IXO35_013690	COG3039	Transposase
IXO35_013740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO35_013755	COG0233	cytoplasmic translational termination
IXO35_013765	COG0575	Belongs to the CDS family
IXO35_013775	COG0750	zinc metalloprotease
IXO35_013795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO35_013800	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO35_013820	COG0825	malonyl-CoA metabolic process
IXO35_013830	COG4771	TonB-dependent receptor
IXO35_013835	COG1131	(ABC) transporter
IXO35_013855	COG1981	membrane
IXO35_013900	COG0529	Catalyzes the synthesis of activated sulfate
IXO35_013900	COG2895	sulfate adenylyltransferase (ATP) activity
IXO35_013935	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO35_013950	COG2040	homocysteine
IXO35_013955	COG0833	amino acid
IXO35_013975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO35_013975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO35_013985	COG2878	Part of a membrane complex involved in electron transport
IXO35_014000	COG1595	DNA-templated transcription, initiation
IXO35_014025	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO35_014040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO35_014045	COG0251	oxidation-reduction process
IXO35_014055	COG0392	lysyltransferase activity
IXO35_014055	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO35_014085	COG3039	Transposase
IXO35_014100	COG2814	Major facilitator Superfamily
IXO35_014105	COG1902	pentaerythritol trinitrate reductase activity
IXO35_014115	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO35_014130	COG1047	Peptidyl-prolyl cis-trans
IXO35_014170	COG3039	Transposase
IXO35_014175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO35_014190	COG1451	nucleotide metabolic process
IXO35_014210	COG0183	Belongs to the thiolase family
IXO35_014240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO35_014240	COG1793	dna ligase
IXO35_014250	COG1793	dna ligase
IXO35_014255	COG1201	RNA secondary structure unwinding
IXO35_014275	COG1278	Cold shock
IXO35_014280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO35_014285	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO35_014295	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO35_014305	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO35_014335	COG3039	Transposase
IXO35_014345	COG2954	triphosphatase activity
IXO35_014360	COG1381	Involved in DNA repair and RecF pathway recombination
IXO35_014390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO35_014405	COG1024	Enoyl-CoA hydratase
IXO35_014405	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO35_014425	COG1024	Enoyl-CoA hydratase
IXO35_014430	COG1960	acyl-CoA dehydrogenase activity
IXO35_014500	COG2353	YceI-like domain
IXO35_014510	COG2353	YceI-like domain
IXO35_014525	COG1760	l-serine dehydratase
IXO35_014535	COG0626	cystathionine gamma-synthase activity
IXO35_014540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO35_014545	COG0739	heme binding
IXO35_014555	COG1272	protein, Hemolysin III
IXO35_014575	COG0463	Glycosyl transferase, family 2
IXO35_014585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO35_014595	COG4771	TonB-dependent receptor
IXO35_014600	COG1309	transcriptional regulator
IXO35_014610	COG1960	acyl-CoA dehydrogenase activity
IXO35_014640	COG0509	glycine decarboxylation via glycine cleavage system
IXO35_014655	COG0330	HflC and HflK could
IXO35_014670	COG3956	TIGRFAM MazG family protein
IXO35_014680	COG0494	nUDIX hydrolase
IXO35_014690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO35_014695	COG0837	glucose binding
IXO35_014710	COG1388	LysM domain
IXO35_014710	COG3858	chitin binding
IXO35_014730	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO35_014770	COG3537	Alpha-1,2-mannosidase
IXO35_014810	COG3142	Participates in the control of copper homeostasis
IXO35_014815	COG1446	asparaginase
IXO35_014840	COG3039	Transposase
IXO35_014860	COG0784	Response regulator, receiver
IXO35_014860	COG2198	Histidine kinase
IXO35_014860	COG0643	Histidine kinase
IXO35_014865	COG0840	transmembrane signaling receptor activity
IXO35_014870	COG0835	chemotaxis
IXO35_014885	COG0189	ligase activity
IXO35_014895	COG1397	ADP-ribosylglycohydrolase
IXO35_014905	COG1199	ATP-dependent helicase activity
IXO35_014915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO35_014920	COG1215	transferase activity, transferring glycosyl groups
IXO35_014930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO35_014950	COG0535	radical SAM domain protein
IXO35_014955	COG0535	radical SAM domain protein
IXO35_014980	COG1643	Atp-dependent helicase
IXO35_014985	COG0783	Belongs to the Dps family
IXO35_014990	COG0514	ATP-dependent DNA helicase (RecQ)
IXO35_015015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO35_015065	COG1187	pseudouridine synthase activity
IXO35_015075	COG0602	queuosine metabolic process
IXO35_015085	COG2885	chlorophyll binding
IXO35_015100	COG0848	biopolymer transport protein
IXO35_015110	COG0824	Thioesterase
IXO35_015115	COG2255	four-way junction helicase activity
IXO35_015125	COG0632	four-way junction helicase activity
IXO35_015255	COG3209	COG3209 Rhs family protein
IXO35_015275	COG3209	COG3209 Rhs family protein
IXO35_015275	COG3209	COG3209 Rhs family protein
IXO35_015295	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO35_015300	COG1845	cytochrome c oxidase, subunit III
IXO35_015305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO35_015320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO35_015325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO35_015335	COG0196	riboflavin kinase activity
IXO35_015340	COG0728	peptidoglycan biosynthetic process
IXO35_015345	COG0268	Binds directly to 16S ribosomal RNA
IXO35_015350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO35_015355	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO35_015365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO35_015370	COG0824	Thioesterase
IXO35_015385	COG1946	Acyl-CoA thioesterase
IXO35_015395	COG1595	DNA-templated transcription, initiation
IXO35_015410	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO35_015450	COG1877	trehalose-phosphatase activity
IXO35_015455	COG3387	PFAM Glycoside hydrolase 15-related
IXO35_015480	COG0564	pseudouridine synthase activity
IXO35_015485	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO35_015490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO35_015490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO35_015500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO35_015505	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO35_015545	COG2194	sulfuric ester hydrolase activity
IXO35_015550	COG4969	Belongs to the N-Me-Phe pilin family
IXO35_015560	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO35_015580	COG3039	Transposase
IXO35_015630	COG1132	(ABC) transporter
IXO35_015660	COG0745	RESPONSE REGULATOR receiver
IXO35_015665	COG5000	phosphorelay sensor kinase activity
IXO35_015665	COG5002	protein histidine kinase activity
IXO35_015670	COG0475	glutathione-regulated potassium exporter activity
IXO35_015680	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO35_015700	COG1187	pseudouridine synthase activity
IXO35_015705	COG5001	Diguanylate cyclase
IXO35_015705	COG5002	protein histidine kinase activity
IXO35_015805	COG1028	Short-chain dehydrogenase reductase Sdr
IXO35_015820	COG0415	Belongs to the DNA photolyase family
IXO35_015825	COG0305	Participates in initiation and elongation during chromosome replication
IXO35_015835	COG0367	asparagine synthase
IXO35_015850	COG1960	acyl-CoA dehydrogenase activity
IXO35_015865	COG0084	hydrolase, TatD family'
IXO35_015870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO35_015930	COG0735	belongs to the Fur family
IXO35_015935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO35_015955	COG3039	Transposase
IXO35_015965	COG3039	Transposase
IXO35_015975	COG3039	Transposase
IXO35_016025	COG2205	protein histidine kinase activity
IXO35_016040	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO35_016050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO35_016065	COG2198	Histidine kinase
IXO35_016065	COG0643	Histidine kinase
IXO35_016070	COG0840	transmembrane signaling receptor activity
IXO35_016075	COG0835	chemotaxis
IXO35_016080	COG2199	diguanylate cyclase activity
IXO35_016080	COG2202	Pas domain
IXO35_016080	COG2200	EAL domain
IXO35_016085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO35_016100	COG3590	peptidase
IXO35_016115	COG0588	phosphoglycerate mutase activity
IXO35_016120	COG1515	deoxyribonuclease V activity
IXO35_016130	COG1741	Belongs to the pirin family
IXO35_016195	COG1741	Belongs to the pirin family
IXO35_016200	COG1966	Carbon starvation protein
IXO35_016205	COG2879	small protein
IXO35_016245	COG2203	Gaf domain
IXO35_016245	COG5001	Diguanylate cyclase
IXO35_016245	COG4251	negative regulation of phosphorylation
IXO35_016245	COG3706	GGDEF domain
IXO35_016250	COG0629	single-stranded DNA binding
IXO35_016255	COG0142	geranyltranstransferase activity
IXO35_016280	COG0527	aspartate kinase activity
IXO35_016290	COG0384	phenazine biosynthesis protein PhzF
IXO35_016300	COG1764	response to oxidative stress
IXO35_016315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO35_016320	COG1678	Uncharacterized ACR, COG1678
IXO35_016330	COG0519	Catalyzes the synthesis of GMP from XMP
IXO35_016360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO35_016405	COG0693	protein deglycase activity
IXO35_016425	COG1959	2 iron, 2 sulfur cluster binding
IXO35_016430	COG0719	Fe-S assembly protein
IXO35_016435	COG0396	ATPase activity
IXO35_016440	COG0719	Fe-S assembly protein
IXO35_016445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO35_016455	COG2146	nitrite reductase [NAD(P)H] activity
IXO35_016480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO35_016495	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO35_016505	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO35_016510	COG0174	glutamine synthetase
IXO35_016515	COG3328	transposase activity
IXO35_016540	COG0326	Molecular chaperone. Has ATPase activity
IXO35_016545	COG2207	Transcriptional regulator
IXO35_016570	COG0657	acetylesterase activity
IXO35_016570	COG2755	lipolytic protein G-D-S-L family
IXO35_016595	COG0488	(ABC) transporter
IXO35_016630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO35_016630	COG4651	solute:proton antiporter activity
IXO35_016645	COG4772	TonB-dependent receptor
IXO35_016655	COG4264	IucA IucC family
IXO35_016660	COG2814	Major facilitator Superfamily
IXO35_016670	COG0019	diaminopimelate decarboxylase activity
IXO35_016730	COG4206	TonB-dependent receptor
IXO35_016765	COG0542	response to heat
IXO35_016810	COG0534	Mate efflux family protein
IXO35_016825	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO35_016830	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO35_016835	COG0228	four-way junction DNA binding
IXO35_016860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO35_016870	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO35_016920	COG1555	photosystem II stabilization
IXO35_016925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO35_016940	COG3178	'Phosphotransferase
IXO35_016945	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO35_016955	COG0628	permease
IXO35_016965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO35_016980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO35_017005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO35_017015	COG0271	Belongs to the BolA IbaG family
IXO35_017025	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO35_017035	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO35_017040	COG1137	ATPase activity
IXO35_017055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO35_017060	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO35_017065	COG1660	Displays ATPase and GTPase activities
IXO35_017075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO35_017080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO35_017085	COG2239	Acts as a magnesium transporter
IXO35_017095	COG1294	oxidase, subunit
IXO35_017100	COG1271	oxidase subunit
IXO35_017120	COG1113	amino acid transport
IXO35_017135	COG2197	response regulator
IXO35_017140	COG0531	amino acid
IXO35_017200	COG0754	glutathionylspermidine amidase activity
IXO35_017225	COG1842	Phage shock protein A
IXO35_017240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO35_017245	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXO35_017255	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO35_017285	COG2201	protein-glutamate methylesterase activity
IXO35_017340	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO35_017385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO35_017390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO35_017415	COG3039	Transposase
IXO35_017430	COG0745	RESPONSE REGULATOR receiver
IXO35_017435	COG2205	protein histidine kinase activity
IXO35_017455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO35_017485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO35_017485	COG3453	Protein conserved in bacteria
IXO35_017490	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO35_017495	COG4149	molybdate abc transporter
IXO35_017500	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO35_017520	COG0642	Histidine kinase
IXO35_017535	COG1028	Short-chain dehydrogenase reductase Sdr
IXO35_017545	COG1022	Amp-dependent synthetase and ligase
IXO35_017570	COG1376	ErfK ybiS ycfS ynhG family protein
IXO35_017575	COG0739	heme binding
IXO35_017585	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO35_017590	COG1301	dicarboxylic acid transport
IXO35_017610	COG2304	oxidoreductase activity
IXO35_017630	COG0714	Associated with various cellular activities
IXO35_017675	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO35_017700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO35_017710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO35_017735	COG1561	YicC-like family, N-terminal region
IXO35_017740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO35_017755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO35_017785	COG0006	proline dipeptidase activity
IXO35_017810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO35_017820	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO35_017830	COG2912	Transglutaminase-like superfamily
IXO35_017835	COG1773	rubredoxin
IXO35_017840	COG0352	thiamine-phosphate diphosphorylase activity
IXO35_017910	COG0280	phosphate acetyltransferase
IXO35_017910	COG0281	malic enzyme
IXO35_017930	COG4191	Histidine kinase
IXO35_017945	COG0583	DNA-binding transcription factor activity
IXO35_017960	COG2197	response regulator
IXO35_017970	COG0642	Histidine kinase
IXO35_017985	COG2851	Citrate transporter
IXO35_017990	COG1028	Short-chain dehydrogenase reductase Sdr
IXO35_017995	COG1609	Transcriptional regulator
IXO35_018005	COG2211	Major facilitator Superfamily
IXO35_018030	COG1162	GTPase activity
IXO35_018055	COG0726	polysaccharide deacetylase
IXO35_018060	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO35_018085	COG3039	Transposase
IXO35_018090	COG3039	Transposase
IXO35_018135	COG0242	peptide deformylase activity
IXO35_018155	COG0714	Associated with various cellular activities
IXO35_018175	COG0537	adenosine 5'-monophosphoramidase activity
IXO35_018205	COG0314	molybdopterin synthase activity
IXO35_018210	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO35_018215	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO35_018225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO35_018230	COG1234	tRNA 3'-trailer cleavage
IXO35_018235	COG3642	lipopolysaccharide core region biosynthetic process
IXO35_018240	COG0859	PFAM glycosyl transferase family 9
IXO35_018250	COG0582	viral genome integration into host DNA
IXO35_018305	COG0631	protein serine/threonine phosphatase activity
IXO35_018315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO35_018340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO35_018380	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO35_018430	COG0473	3-isopropylmalate dehydrogenase activity
IXO35_018455	COG4783	chaperone-mediated protein folding
IXO35_018470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO35_018480	COG0438	transferase activity, transferring glycosyl groups
IXO35_018485	COG0671	phosphoesterase, PA-phosphatase related
IXO35_018490	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO35_018510	COG2833	Protein of unknown function (DUF455)
IXO35_018530	COG0285	dihydrofolate synthase activity
IXO35_018540	COG0588	phosphoglycerate mutase activity
IXO35_018570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO35_018575	COG4208	sulfate ABC transporter
IXO35_018580	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO35_018585	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO35_018590	COG0156	8-amino-7-oxononanoate synthase activity
IXO35_018615	COG0604	alcohol dehydrogenase
IXO35_018620	COG1902	pentaerythritol trinitrate reductase activity
IXO35_018620	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO35_018705	COG0697	spore germination
IXO35_018735	COG3386	PFAM SMP-30 Gluconolaconase
IXO35_018755	COG1024	Enoyl-CoA hydratase
IXO35_018765	COG0318	PFAM AMP-dependent synthetase and ligase
IXO35_018770	COG0583	DNA-binding transcription factor activity
IXO35_018810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO35_018815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO35_018825	COG2096	Adenosyltransferase
IXO35_018830	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO35_018845	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO35_018855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO35_018860	COG2967	ApaG domain
IXO35_018885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO35_018905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO35_018925	COG0642	Histidine kinase
IXO35_018940	COG4181	ATPase activity
IXO35_018955	COG2175	clavaminate synthase activity
IXO35_019010	COG0667	Aldo Keto reductase
IXO35_019020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO35_019025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO35_019035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO35_019050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO35_019105	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO35_019110	COG2226	methyltransferase
IXO35_019160	COG0604	alcohol dehydrogenase
IXO35_019160	COG1028	Short-chain dehydrogenase reductase Sdr
IXO35_019160	COG3321	synthase
IXO35_019170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO35_019185	COG0494	nUDIX hydrolase
IXO35_019200	COG4942	peptidase
IXO35_019200	COG1388	LysM domain
IXO35_019210	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO35_019225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO35_019230	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO35_019235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO35_019250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO35_019255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO35_019270	COG3116	cell division
IXO35_019275	COG0275	rRNA processing
IXO35_019310	COG0792	nuclease activity
IXO35_019315	COG1988	membrane-bound metal-dependent
IXO35_019320	COG0277	FAD linked oxidase domain protein
IXO35_019325	COG0745	RESPONSE REGULATOR receiver
IXO35_019330	COG2205	protein histidine kinase activity
IXO35_019340	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO35_019345	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO35_019365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO35_019370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO35_019375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO35_019395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO35_019395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO35_019415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO35_019435	COG0488	(ABC) transporter
IXO35_019485	COG2205	protein histidine kinase activity
IXO35_019530	COG2205	protein histidine kinase activity
IXO35_019545	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO35_019580	COG3039	Transposase
IXO35_019595	COG3039	Transposase
IXO35_019680	COG1649	PFAM Uncharacterised BCR, COG1649
IXO35_019680	COG0726	polysaccharide deacetylase
IXO35_019685	COG1215	transferase activity, transferring glycosyl groups
IXO35_019695	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO35_019700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO35_019705	COG1609	Transcriptional regulator
IXO35_019715	COG2188	Transcriptional regulator
IXO35_019730	COG3250	beta-galactosidase activity
IXO35_019780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO35_019785	COG4191	Histidine kinase
IXO35_019790	COG0784	Response regulator, receiver
IXO35_019795	COG4251	negative regulation of phosphorylation
IXO35_019800	COG2823	Periplasmic or secreted lipoprotein
IXO35_019805	COG0673	inositol 2-dehydrogenase activity
IXO35_019810	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO35_019845	COG1056	cytidyltransferase-related domain
IXO35_019845	COG1051	belongs to the nudix hydrolase family
IXO35_019870	COG2921	Belongs to the UPF0250 family
IXO35_019880	COG1686	Belongs to the peptidase S11 family
IXO35_019885	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO35_019890	COG2951	lytic endotransglycosylase activity
IXO35_019960	COG0772	Belongs to the SEDS family
IXO35_019975	COG1792	Involved in formation and maintenance of cell shape
IXO35_019980	COG1077	Cell shape determining protein MreB Mrl
IXO35_019985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO35_020035	COG2199	diguanylate cyclase activity
IXO35_020040	COG0308	aminopeptidase N
IXO35_020070	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO35_020100	COG0436	Aminotransferase
IXO35_020125	COG1505	serine-type exopeptidase activity
IXO35_020150	COG0181	hydroxymethylbilane synthase activity
IXO35_020160	COG3275	phosphorelay sensor kinase activity
IXO35_020200	COG0659	secondary active sulfate transmembrane transporter activity
IXO35_020205	COG5297	Belongs to the glycosyl hydrolase family 6
IXO35_020205	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO35_020275	COG0598	Magnesium transport protein CorA
IXO35_020285	COG1113	amino acid transport
IXO35_020290	COG5297	Belongs to the glycosyl hydrolase family 6
IXO35_020295	COG4305	rare lipoprotein A
IXO35_020300	COG0697	spore germination
IXO35_020355	COG4221	oxidoreductase activity
IXO35_020385	COG0456	acetyltransferase
IXO35_020395	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO35_020440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO35_020440	COG2111	Na H antiporter
IXO35_020445	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO35_020450	COG0651	ATP synthesis coupled electron transport
IXO35_020460	COG2212	antiporter activity
IXO35_020465	COG1320	monovalent cation:proton antiporter activity
IXO35_020475	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO35_020495	COG3104	oligopeptide transport
IXO35_020500	COG3483	tryptophan 2,3-dioxygenase activity
IXO35_020510	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IXO35_020550	COG0183	Belongs to the thiolase family
IXO35_020620	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO35_020625	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO35_020635	COG4948	Mandelate Racemase Muconate Lactonizing
IXO35_020660	COG0531	amino acid
IXO35_020685	COG4682	membrane
IXO35_020690	COG2133	pyrroloquinoline quinone binding
IXO35_020730	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO35_020735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO35_020745	COG1610	YqeY-like protein
IXO35_020755	COG1295	ribonuclease BN
IXO35_020760	COG0358	DNA primase activity
IXO35_020825	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO35_020840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO35_020890	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO35_020895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO35_020900	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO35_020910	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO35_020915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO35_020925	COG0134	indole-3-glycerol-phosphate synthase activity
IXO35_020930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO35_020995	COG3039	Transposase
IXO35_021015	COG3039	Transposase
IXO35_021030	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO35_021030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO35_021040	COG1473	amidohydrolase
IXO35_021045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO35_021050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO35_021065	COG5383	Protein conserved in bacteria
IXO35_021105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO35_021110	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO35_021125	COG0028	Belongs to the TPP enzyme family
IXO35_021135	COG4191	Histidine kinase
IXO35_021160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO35_021175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO35_021180	COG3177	Filamentation induced by cAMP protein fic
IXO35_021195	COG0596	Alpha beta hydrolase
IXO35_021200	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO35_021205	COG0318	PFAM AMP-dependent synthetase and ligase
IXO35_021210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO35_021260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO35_021270	COG0129	dihydroxy-acid dehydratase activity
IXO35_021295	COG3039	Transposase
IXO35_021305	COG0408	coproporphyrinogen oxidase activity
IXO35_021345	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXO35_021405	COG2353	YceI-like domain
IXO35_021435	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO35_021450	COG3386	PFAM SMP-30 Gluconolaconase
IXO35_021490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO35_021505	COG4771	TonB-dependent receptor
IXO35_021515	COG0459	protein refolding
IXO35_021545	COG1252	NADH dehydrogenase
IXO35_021555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO35_021560	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO35_021565	COG3437	response regulator, receiver
IXO35_021570	COG2177	Part of the ABC transporter FtsEX involved in
IXO35_021575	COG2884	Cell division ATP-binding protein ftsE
IXO35_021585	COG3118	belongs to the thioredoxin family
IXO35_021590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO35_021605	COG0729	surface antigen
IXO35_021610	COG2911	Protein conserved in bacteria
IXO35_021645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO35_021660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO35_021715	COG1733	regulation of RNA biosynthetic process
IXO35_021720	COG0702	epimerase
IXO35_021750	COG0583	DNA-binding transcription factor activity
IXO35_021755	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO35_021775	COG0745	RESPONSE REGULATOR receiver
IXO35_021805	COG1902	pentaerythritol trinitrate reductase activity
IXO35_021810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO35_021820	COG2814	Major facilitator Superfamily
IXO35_021825	COG0583	DNA-binding transcription factor activity
IXO35_021840	COG0084	hydrolase, TatD family'
IXO35_021885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO35_021905	COG2072	flavoprotein involved in K transport
IXO35_021960	COG4770	biotin carboxylase activity
IXO35_021965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO35_021970	COG1960	acyl-CoA dehydrogenase activity
IXO35_022020	COG0523	cobalamin synthesis protein
IXO35_022030	COG0697	spore germination
IXO35_022040	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO35_022055	COG4771	TonB-dependent receptor
IXO35_022060	COG0457	Tetratricopeptide repeat
IXO35_022070	COG0752	glycyl-tRNA synthetase alpha subunit
IXO35_022075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO35_022090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO35_022090	COG0519	Catalyzes the synthesis of GMP from XMP
IXO35_022100	COG0805	protein transport
IXO35_022110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO35_022120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO35_022145	COG2974	May be involved in recombination
IXO35_022150	COG0037	tRNA processing
IXO35_022165	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO35_022175	COG4948	Mandelate Racemase Muconate Lactonizing
IXO35_022185	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO35_022190	COG0246	Mannitol dehydrogenase
IXO35_022215	COG3693	PFAM glycoside hydrolase, family 10
IXO35_022235	COG2211	Major facilitator Superfamily
IXO35_022285	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IXO35_022325	COG1846	Transcriptional regulator
IXO35_022330	COG1764	response to oxidative stress
IXO35_022415	COG3549	Plasmid maintenance system killer
IXO35_022425	COG1074	ATP-dependent DNA helicase activity
IXO35_022430	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO35_022475	COG2032	superoxide dismutase activity
IXO35_022480	COG2032	superoxide dismutase activity
IXO35_022485	COG2204	response regulator
IXO35_022490	COG3852	Histidine kinase
IXO35_022495	COG0004	ammonium transporteR
IXO35_022500	COG0347	Belongs to the P(II) protein family
IXO35_022505	COG0174	glutamine synthetase
IXO35_022510	COG1968	undecaprenyl-diphosphatase activity
IXO35_022555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO35_022565	COG2062	phosphohistidine phosphatase, SixA
IXO35_022570	COG0489	protein tyrosine kinase activity
IXO35_022590	COG1396	sequence-specific DNA binding
IXO35_022595	COG3550	peptidyl-serine autophosphorylation
IXO35_022600	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO35_022605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO35_022620	COG0517	IMP dehydrogenase activity
IXO35_022620	COG1125	glycine betaine transport
IXO35_022635	COG1119	ATPase activity
IXO35_022645	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO35_022660	COG3039	Transposase
IXO35_022685	COG0656	L-ascorbic acid biosynthetic process
IXO35_022690	COG2130	NADP-dependent
IXO35_022695	COG0667	Aldo Keto reductase
IXO35_022705	COG1187	pseudouridine synthase activity
IXO35_022715	COG1643	Atp-dependent helicase
IXO35_022720	COG4807	Protein conserved in bacteria
IXO35_022725	COG4948	Mandelate Racemase Muconate Lactonizing
IXO35_022730	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO35_022735	COG1028	Short-chain dehydrogenase reductase Sdr
IXO35_022755	COG3507	Belongs to the glycosyl hydrolase 43 family
IXO35_022795	COG3162	membrane
IXO35_022800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO35_022815	COG0708	Exodeoxyribonuclease III
IXO35_022830	COG2091	lysine biosynthetic process via aminoadipic acid
IXO35_022840	COG3540	Alkaline phosphatase
IXO35_022845	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO35_022875	COG2159	amidohydrolase
IXO35_022885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO35_022890	COG0583	DNA-binding transcription factor activity
IXO35_022895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO35_022910	COG0210	DNA helicase
IXO35_022930	COG0531	amino acid
IXO35_022935	COG1322	Protein conserved in bacteria
IXO35_022945	COG0386	Belongs to the glutathione peroxidase family
IXO35_023000	COG0793	Belongs to the peptidase S41A family
IXO35_023005	COG4942	peptidase
IXO35_023015	COG2234	aminopeptidase activity
IXO35_023060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO35_023065	COG0302	gtp cyclohydrolase
IXO35_023090	COG0477	Major facilitator Superfamily
IXO35_023145	COG1929	Belongs to the glycerate kinase type-1 family
IXO35_023150	COG2271	Major facilitator Superfamily
IXO35_023165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO35_023170	COG0861	Integral membrane protein TerC family
IXO35_023185	COG0584	glycerophosphoryl diester phosphodiesterase
IXO35_023195	COG0671	phosphoesterase, PA-phosphatase related
IXO35_023200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IXO35_023205	COG0726	polysaccharide deacetylase
IXO35_023240	COG3846	protein secretion by the type IV secretion system
IXO35_023275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO35_023415	COG0489	protein tyrosine kinase activity
IXO35_023455	COG4962	Type ii secretion system protein e
IXO35_023460	COG3838	Conjugal transfer protein Trbc
IXO35_023485	COG3704	protein secretion by the type IV secretion system
IXO35_023495	COG3504	Conjugal transfer protein
IXO35_023500	COG2948	multi-organism process
IXO35_023505	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
IXO35_023520	COG0741	lytic transglycosylase activity
IXO35_023535	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IXO35_023565	COG1475	DNA binding
IXO35_023570	COG1192	Involved in chromosome partitioning