locus-tag	class	description
IXO365_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO365_000020	COG0187	DNA topoisomerase II activity
IXO365_000030	COG0501	Belongs to the peptidase M48B family
IXO365_000060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO365_000070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO365_000080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO365_000090	COG4772	TonB-dependent receptor
IXO365_000110	COG1304	FMN binding
IXO365_000140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO365_000225	COG2826	transposase and inactivated derivatives, IS30 family
IXO365_000250	COG3039	Transposase
IXO365_000260	COG1090	epimerase
IXO365_000270	COG0642	Histidine kinase
IXO365_000280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO365_000390	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO365_000465	COG3264	Mechanosensitive ion channel
IXO365_000465	COG1511	domain protein
IXO365_000480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO365_000485	COG2354	Protein conserved in bacteria
IXO365_000490	COG1649	PFAM Uncharacterised BCR, COG1649
IXO365_000510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO365_000535	COG0702	epimerase
IXO365_000550	COG1858	cytochrome C peroxidase
IXO365_000625	COG0513	Belongs to the DEAD box helicase family
IXO365_000630	COG3039	Transposase
IXO365_000675	COG1136	(ABC) transporter
IXO365_000715	COG1136	(ABC) transporter
IXO365_000755	COG1272	protein, Hemolysin III
IXO365_000760	COG1111	helicase
IXO365_000760	COG1205	dead DEAH box helicase
IXO365_000820	COG0069	glutamate synthase activity
IXO365_000820	COG0070	glutamate synthase
IXO365_000820	COG0067	glutamate synthase
IXO365_000825	COG0493	'glutamate synthase
IXO365_000870	COG1609	Transcriptional regulator
IXO365_000900	COG0366	Alpha amylase catalytic
IXO365_000905	COG0366	Alpha amylase catalytic
IXO365_000945	COG0606	chelatase, subunit chli
IXO365_000985	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO365_000990	COG1166	arginine decarboxylase activity
IXO365_001065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO365_001090	COG1028	Short-chain dehydrogenase reductase Sdr
IXO365_001115	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO365_001130	COG0210	DNA helicase
IXO365_001145	COG3132	Protein of unknown function, DUF480
IXO365_001150	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO365_001155	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO365_001190	COG2937	Belongs to the GPAT DAPAT family
IXO365_001195	COG1028	Short-chain dehydrogenase reductase Sdr
IXO365_001195	COG0604	alcohol dehydrogenase
IXO365_001195	COG3321	synthase
IXO365_001230	COG3186	Phenylalanine-4-hydroxylase
IXO365_001235	COG1522	sequence-specific DNA binding
IXO365_001280	COG1064	alcohol dehydrogenase
IXO365_001285	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO365_001290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO365_001300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO365_001320	COG0676	glucose-6-phosphate 1-epimerase activity
IXO365_001385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO365_001405	COG2853	Lipoprotein
IXO365_001420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO365_001425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO365_001430	COG1127	ABC transporter
IXO365_001505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO365_001510	COG3265	gluconokinase activity
IXO365_001515	COG2211	Major facilitator Superfamily
IXO365_001520	COG3459	Glycosyltransferase 36 associated
IXO365_001530	COG2205	protein histidine kinase activity
IXO365_001540	COG1414	Transcriptional regulator
IXO365_001545	COG0738	Major facilitator superfamily
IXO365_001550	COG3254	rhamnose metabolic process
IXO365_001580	COG0339	signal peptide processing
IXO365_001610	COG0564	pseudouridine synthase activity
IXO365_001620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO365_001630	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO365_001670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO365_001680	COG0842	Transport permease protein
IXO365_001685	COG1131	(ABC) transporter
IXO365_001715	COG1476	TRANSCRIPTIONal
IXO365_001725	COG4555	ABC transporter
IXO365_001760	COG0625	glutathione transferase activity
IXO365_001805	COG0583	DNA-binding transcription factor activity
IXO365_001845	COG1199	ATP-dependent helicase activity
IXO365_001865	COG1566	PFAM secretion protein HlyD family protein
IXO365_001885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO365_001925	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO365_001925	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO365_001930	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO365_001945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO365_001980	COG3237	CsbD-like
IXO365_001985	COG0180	Tryptophanyl-tRNA synthetase
IXO365_001990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO365_002035	COG0753	catalase activity
IXO365_002040	COG1595	DNA-templated transcription, initiation
IXO365_002050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO365_002060	COG0628	permease
IXO365_002070	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO365_002075	COG1040	competence protein
IXO365_002080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO365_002085	COG0156	8-amino-7-oxononanoate synthase activity
IXO365_002095	COG1028	Short-chain dehydrogenase reductase Sdr
IXO365_002110	COG0463	Glycosyl transferase, family 2
IXO365_002120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO365_002125	COG3100	YcgL domain-containing protein
IXO365_002140	COG3387	PFAM Glycoside hydrolase 15-related
IXO365_002145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO365_002150	COG3039	Transposase
IXO365_002210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO365_002225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO365_002230	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO365_002240	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO365_002245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO365_002250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO365_002300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO365_002315	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO365_002380	COG0358	DNA primase activity
IXO365_002385	COG1295	ribonuclease BN
IXO365_002395	COG1610	YqeY-like protein
IXO365_002405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO365_002410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO365_002450	COG2133	pyrroloquinoline quinone binding
IXO365_002455	COG4682	membrane
IXO365_002480	COG0531	amino acid
IXO365_002510	COG4948	Mandelate Racemase Muconate Lactonizing
IXO365_002520	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO365_002525	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO365_002595	COG0183	Belongs to the thiolase family
IXO365_002635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IXO365_002645	COG3483	tryptophan 2,3-dioxygenase activity
IXO365_002650	COG3104	oligopeptide transport
IXO365_002680	COG1320	monovalent cation:proton antiporter activity
IXO365_002685	COG2212	antiporter activity
IXO365_002695	COG0651	ATP synthesis coupled electron transport
IXO365_002700	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO365_002705	COG2111	Na H antiporter
IXO365_002705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO365_002755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO365_002765	COG0456	acetyltransferase
IXO365_002785	COG2801	Transposase and inactivated derivatives
IXO365_002795	COG4221	oxidoreductase activity
IXO365_002840	COG3039	Transposase
IXO365_002860	COG0697	spore germination
IXO365_002865	COG4305	rare lipoprotein A
IXO365_002870	COG5297	Belongs to the glycosyl hydrolase family 6
IXO365_002880	COG1113	amino acid transport
IXO365_002890	COG0598	Magnesium transport protein CorA
IXO365_002960	COG5297	Belongs to the glycosyl hydrolase family 6
IXO365_002960	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO365_002965	COG0659	secondary active sulfate transmembrane transporter activity
IXO365_003000	COG3275	phosphorelay sensor kinase activity
IXO365_003010	COG0181	hydroxymethylbilane synthase activity
IXO365_003035	COG1505	serine-type exopeptidase activity
IXO365_003050	COG3039	Transposase
IXO365_003055	COG0436	Aminotransferase
IXO365_003085	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO365_003115	COG0308	aminopeptidase N
IXO365_003120	COG2199	diguanylate cyclase activity
IXO365_003170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO365_003175	COG1077	Cell shape determining protein MreB Mrl
IXO365_003180	COG1792	Involved in formation and maintenance of cell shape
IXO365_003195	COG0772	Belongs to the SEDS family
IXO365_003230	COG2951	lytic endotransglycosylase activity
IXO365_003235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO365_003240	COG1686	Belongs to the peptidase S11 family
IXO365_003255	COG2921	Belongs to the UPF0250 family
IXO365_003280	COG1056	cytidyltransferase-related domain
IXO365_003280	COG1051	belongs to the nudix hydrolase family
IXO365_003315	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO365_003320	COG0673	inositol 2-dehydrogenase activity
IXO365_003325	COG2823	Periplasmic or secreted lipoprotein
IXO365_003330	COG4251	negative regulation of phosphorylation
IXO365_003335	COG0784	Response regulator, receiver
IXO365_003340	COG4191	Histidine kinase
IXO365_003345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO365_003395	COG3250	beta-galactosidase activity
IXO365_003410	COG2188	Transcriptional regulator
IXO365_003420	COG1609	Transcriptional regulator
IXO365_003425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO365_003430	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO365_003440	COG1215	transferase activity, transferring glycosyl groups
IXO365_003445	COG0726	polysaccharide deacetylase
IXO365_003445	COG1649	PFAM Uncharacterised BCR, COG1649
IXO365_003530	COG3039	Transposase
IXO365_003535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO365_003540	COG3039	Transposase
IXO365_003575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO365_003590	COG2205	protein histidine kinase activity
IXO365_003625	COG2205	protein histidine kinase activity
IXO365_003665	COG3039	Transposase
IXO365_003680	COG0488	(ABC) transporter
IXO365_003700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO365_003720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO365_003720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO365_003740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO365_003745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO365_003750	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO365_003770	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO365_003775	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO365_003785	COG2205	protein histidine kinase activity
IXO365_003790	COG0745	RESPONSE REGULATOR receiver
IXO365_003795	COG0277	FAD linked oxidase domain protein
IXO365_003800	COG1988	membrane-bound metal-dependent
IXO365_003805	COG0792	nuclease activity
IXO365_003840	COG0275	rRNA processing
IXO365_003845	COG3116	cell division
IXO365_003860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO365_003865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO365_003880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO365_003885	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO365_003890	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO365_003905	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO365_003915	COG1388	LysM domain
IXO365_003915	COG4942	peptidase
IXO365_003920	COG0653	protein targeting
IXO365_003930	COG0494	nUDIX hydrolase
IXO365_003945	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO365_003955	COG1028	Short-chain dehydrogenase reductase Sdr
IXO365_003955	COG0604	alcohol dehydrogenase
IXO365_003955	COG3321	synthase
IXO365_004005	COG2226	methyltransferase
IXO365_004010	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO365_004045	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO365_004050	COG3039	Transposase
IXO365_004065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO365_004075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO365_004080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO365_004090	COG3039	Transposase
IXO365_004110	COG0667	Aldo Keto reductase
IXO365_004165	COG2175	clavaminate synthase activity
IXO365_004175	COG4181	ATPase activity
IXO365_004190	COG0642	Histidine kinase
IXO365_004215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO365_004235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO365_004260	COG2967	ApaG domain
IXO365_004265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO365_004275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO365_004290	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO365_004295	COG2096	Adenosyltransferase
IXO365_004305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO365_004310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO365_004350	COG0583	DNA-binding transcription factor activity
IXO365_004355	COG0318	PFAM AMP-dependent synthetase and ligase
IXO365_004365	COG1024	Enoyl-CoA hydratase
IXO365_004385	COG3386	PFAM SMP-30 Gluconolaconase
IXO365_004500	COG1902	pentaerythritol trinitrate reductase activity
IXO365_004500	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO365_004505	COG0604	alcohol dehydrogenase
IXO365_004530	COG0156	8-amino-7-oxononanoate synthase activity
IXO365_004535	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO365_004540	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO365_004545	COG4208	sulfate ABC transporter
IXO365_004550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO365_004580	COG0588	phosphoglycerate mutase activity
IXO365_004590	COG0285	dihydrofolate synthase activity
IXO365_004610	COG2833	Protein of unknown function (DUF455)
IXO365_004630	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO365_004635	COG0671	phosphoesterase, PA-phosphatase related
IXO365_004640	COG0438	transferase activity, transferring glycosyl groups
IXO365_004650	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO365_004665	COG4783	chaperone-mediated protein folding
IXO365_004690	COG0473	3-isopropylmalate dehydrogenase activity
IXO365_004740	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO365_004780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO365_004815	COG0631	protein serine/threonine phosphatase activity
IXO365_004885	COG0582	viral genome integration into host DNA
IXO365_004895	COG0859	PFAM glycosyl transferase family 9
IXO365_004900	COG3642	lipopolysaccharide core region biosynthetic process
IXO365_004905	COG1234	tRNA 3'-trailer cleavage
IXO365_004910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO365_004920	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO365_004925	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO365_004930	COG0314	molybdopterin synthase activity
IXO365_004960	COG0537	adenosine 5'-monophosphoramidase activity
IXO365_004980	COG0714	Associated with various cellular activities
IXO365_005000	COG0242	peptide deformylase activity
IXO365_005080	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO365_005085	COG0726	polysaccharide deacetylase
IXO365_005110	COG1162	GTPase activity
IXO365_005135	COG2211	Major facilitator Superfamily
IXO365_005145	COG1609	Transcriptional regulator
IXO365_005150	COG1028	Short-chain dehydrogenase reductase Sdr
IXO365_005155	COG2851	Citrate transporter
IXO365_005170	COG0642	Histidine kinase
IXO365_005180	COG2197	response regulator
IXO365_005195	COG0583	DNA-binding transcription factor activity
IXO365_005210	COG4191	Histidine kinase
IXO365_005230	COG0280	phosphate acetyltransferase
IXO365_005230	COG0281	malic enzyme
IXO365_005300	COG0352	thiamine-phosphate diphosphorylase activity
IXO365_005305	COG1773	rubredoxin
IXO365_005310	COG2912	Transglutaminase-like superfamily
IXO365_005320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO365_005330	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO365_005355	COG0006	proline dipeptidase activity
IXO365_005390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO365_005405	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO365_005410	COG1561	YicC-like family, N-terminal region
IXO365_005435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO365_005445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO365_005470	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO365_005515	COG0714	Associated with various cellular activities
IXO365_005535	COG2304	oxidoreductase activity
IXO365_005555	COG1301	dicarboxylic acid transport
IXO365_005560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO365_005570	COG0739	heme binding
IXO365_005575	COG1376	ErfK ybiS ycfS ynhG family protein
IXO365_005600	COG1022	Amp-dependent synthetase and ligase
IXO365_005610	COG1028	Short-chain dehydrogenase reductase Sdr
IXO365_005625	COG0642	Histidine kinase
IXO365_005645	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO365_005650	COG4149	molybdate abc transporter
IXO365_005655	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO365_005660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO365_005660	COG3453	Protein conserved in bacteria
IXO365_005700	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO365_005720	COG2205	protein histidine kinase activity
IXO365_005725	COG0745	RESPONSE REGULATOR receiver
IXO365_005780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO365_005785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO365_005835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO365_005850	COG2801	Transposase and inactivated derivatives
IXO365_005920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO365_005930	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXO365_005935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO365_005950	COG1842	Phage shock protein A
IXO365_005975	COG0754	glutathionylspermidine amidase activity
IXO365_006030	COG0531	amino acid
IXO365_006035	COG2197	response regulator
IXO365_006050	COG1113	amino acid transport
IXO365_006065	COG1271	oxidase subunit
IXO365_006070	COG1294	oxidase, subunit
IXO365_006080	COG2239	Acts as a magnesium transporter
IXO365_006085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO365_006090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO365_006105	COG1660	Displays ATPase and GTPase activities
IXO365_006110	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO365_006115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO365_006130	COG1137	ATPase activity
IXO365_006135	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO365_006145	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO365_006155	COG0271	Belongs to the BolA IbaG family
IXO365_006160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO365_006180	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO365_006195	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO365_006205	COG0628	permease
IXO365_006215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO365_006220	COG3178	'Phosphotransferase
IXO365_006235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO365_006240	COG1555	photosystem II stabilization
IXO365_006290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO365_006300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO365_006320	COG0228	four-way junction DNA binding
IXO365_006325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO365_006330	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO365_006345	COG0534	Mate efflux family protein
IXO365_006380	COG0542	response to heat
IXO365_006415	COG4206	TonB-dependent receptor
IXO365_006475	COG0019	diaminopimelate decarboxylase activity
IXO365_006485	COG2814	Major facilitator Superfamily
IXO365_006490	COG4264	IucA IucC family
IXO365_006500	COG4772	TonB-dependent receptor
IXO365_006515	COG4651	solute:proton antiporter activity
IXO365_006515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO365_006555	COG0488	(ABC) transporter
IXO365_006580	COG0657	acetylesterase activity
IXO365_006580	COG2755	lipolytic protein G-D-S-L family
IXO365_006620	COG2207	Transcriptional regulator
IXO365_006625	COG0326	Molecular chaperone. Has ATPase activity
IXO365_006650	COG3328	transposase activity
IXO365_006655	COG0174	glutamine synthetase
IXO365_006660	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO365_006670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO365_006685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO365_006710	COG2146	nitrite reductase [NAD(P)H] activity
IXO365_006725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO365_006730	COG0719	Fe-S assembly protein
IXO365_006735	COG0396	ATPase activity
IXO365_006740	COG0719	Fe-S assembly protein
IXO365_006745	COG1959	2 iron, 2 sulfur cluster binding
IXO365_006765	COG0693	protein deglycase activity
IXO365_006805	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO365_006835	COG0519	Catalyzes the synthesis of GMP from XMP
IXO365_006845	COG1678	Uncharacterized ACR, COG1678
IXO365_006850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO365_006880	COG1764	response to oxidative stress
IXO365_006890	COG0384	phenazine biosynthesis protein PhzF
IXO365_006900	COG0527	aspartate kinase activity
IXO365_006925	COG0142	geranyltranstransferase activity
IXO365_006930	COG0629	single-stranded DNA binding
IXO365_006935	COG2203	Gaf domain
IXO365_006935	COG3706	GGDEF domain
IXO365_006935	COG4251	negative regulation of phosphorylation
IXO365_006935	COG5001	Diguanylate cyclase
IXO365_006965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO365_007010	COG2879	small protein
IXO365_007015	COG1966	Carbon starvation protein
IXO365_007020	COG1741	Belongs to the pirin family
IXO365_007075	COG3328	transposase activity
IXO365_007090	COG3179	chitinase
IXO365_007115	COG3039	Transposase
IXO365_007140	COG3179	chitinase
IXO365_007275	COG3039	Transposase
IXO365_007280	COG3039	Transposase
IXO365_007360	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO365_007365	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO365_007370	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO365_007375	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO365_007410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO365_007415	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO365_007455	COG0587	DNA-directed DNA polymerase activity
IXO365_007470	COG1297	OPT oligopeptide transporter protein
IXO365_007490	COG0823	Involved in the tonB-independent uptake of proteins
IXO365_007490	COG1506	peptidase
IXO365_007510	COG1917	Cupin 2, conserved barrel domain protein
IXO365_007510	COG2207	Transcriptional regulator
IXO365_007535	COG0753	catalase activity
IXO365_007575	COG0469	pyruvate kinase activity
IXO365_007580	COG3588	fructose-bisphosphate aldolase
IXO365_007585	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO365_007635	COG2198	Histidine kinase
IXO365_007635	COG2205	protein histidine kinase activity
IXO365_007635	COG0784	Response regulator, receiver
IXO365_007655	COG0175	sulfate reduction
IXO365_007660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO365_007665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO365_007670	COG0175	sulfate reduction
IXO365_007675	COG0529	Catalyzes the synthesis of activated sulfate
IXO365_007675	COG2895	sulfate adenylyltransferase (ATP) activity
IXO365_007685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO365_007690	COG0308	aminopeptidase N
IXO365_007715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO365_007735	COG1970	mechanosensitive ion channel activity
IXO365_007765	COG3273	potassium ion transport
IXO365_007765	COG0471	metal ion transport
IXO365_007775	COG2022	thiamine diphosphate biosynthetic process
IXO365_007870	COG3039	Transposase
IXO365_007910	COG3039	Transposase
IXO365_007945	COG3118	belongs to the thioredoxin family
IXO365_007970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO365_007995	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO365_008025	COG2968	Membrane
IXO365_008040	COG3164	Protein of unknown function
IXO365_008050	COG0312	modulator of DNA gyrase
IXO365_008055	COG3028	Belongs to the UPF0307 family
IXO365_008060	COG0312	modulator of DNA gyrase
IXO365_008085	COG0142	geranyltranstransferase activity
IXO365_008090	COG1722	exodeoxyribonuclease VII activity
IXO365_008095	COG0037	tRNA processing
IXO365_008100	COG1785	Belongs to the alkaline phosphatase family
IXO365_008105	COG1301	dicarboxylic acid transport
IXO365_008120	COG0791	NLP P60 protein
IXO365_008125	COG0791	NLP P60 protein
IXO365_008130	COG1047	Peptidyl-prolyl cis-trans
IXO365_008135	COG2311	Membrane
IXO365_008140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO365_008180	COG0489	protein tyrosine kinase activity
IXO365_008185	COG0717	Belongs to the dCTP deaminase family
IXO365_008205	COG0412	Dienelactone hydrolase
IXO365_008215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO365_008255	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO365_008260	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO365_008265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO365_008270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO365_008290	COG0101	tRNA pseudouridine synthase activity
IXO365_008295	COG0135	phosphoribosylanthranilate isomerase activity
IXO365_008315	COG0159	tryptophan synthase activity
IXO365_008320	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO365_008325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO365_008375	COG0149	triose-phosphate isomerase activity
IXO365_008390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO365_008400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO365_008405	COG0649	NAD binding
IXO365_008410	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO365_008415	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO365_008420	COG1034	ATP synthesis coupled electron transport
IXO365_008425	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO365_008455	COG1007	ATP synthesis coupled electron transport
IXO365_008465	COG0779	Required for maturation of 30S ribosomal subunits
IXO365_008470	COG0195	Participates in both transcription termination and antitermination
IXO365_008490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO365_008495	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO365_008530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO365_008540	COG2095	MarC family integral membrane protein
IXO365_008555	COG1611	Belongs to the LOG family
IXO365_008670	COG1192	Involved in chromosome partitioning
IXO365_008765	COG3179	chitinase
IXO365_008810	COG4695	Portal protein
IXO365_008875	COG4969	Belongs to the N-Me-Phe pilin family
IXO365_008880	COG0556	nucleotide-excision repair
IXO365_008915	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO365_008930	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO365_008985	COG0438	transferase activity, transferring glycosyl groups
IXO365_008990	COG0438	transferase activity, transferring glycosyl groups
IXO365_009000	COG0438	transferase activity, transferring glycosyl groups
IXO365_009040	COG3040	lipid binding
IXO365_009070	COG3039	Transposase
IXO365_009135	COG0784	Response regulator, receiver
IXO365_009135	COG4191	Histidine kinase
IXO365_009155	COG0552	protein localization to endoplasmic reticulum
IXO365_009165	COG3938	Belongs to the proline racemase family
IXO365_009170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO365_009185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO365_009195	COG0006	proline dipeptidase activity
IXO365_009210	COG0531	amino acid
IXO365_009260	COG4206	TonB-dependent receptor
IXO365_009345	COG0746	molybdenum cofactor guanylyltransferase activity
IXO365_009370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO365_009370	COG1648	precorrin-2 dehydrogenase activity
IXO365_009415	COG3039	Transposase
IXO365_009425	COG3039	Transposase
IXO365_009465	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO365_009485	COG1054	Belongs to the UPF0176 family
IXO365_009500	COG1530	ribonuclease E activity
IXO365_009510	COG3064	Membrane
IXO365_009515	COG0428	transporter
IXO365_009520	COG0428	transporter
IXO365_009530	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO365_009600	COG3039	Transposase
IXO365_009720	COG0631	protein serine/threonine phosphatase activity
IXO365_009725	COG0515	serine threonine protein kinase
IXO365_009755	COG1858	cytochrome C peroxidase
IXO365_009810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO365_009830	COG2201	protein-glutamate methylesterase activity
IXO365_009860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO365_009880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO365_009895	COG1595	DNA-templated transcription, initiation
IXO365_009945	COG2244	polysaccharide biosynthetic process
IXO365_009975	COG2264	protein methyltransferase activity
IXO365_009985	COG0438	transferase activity, transferring glycosyl groups
IXO365_010000	COG1136	(ABC) transporter
IXO365_010005	COG1132	(ABC) transporter
IXO365_010015	COG0477	Major facilitator Superfamily
IXO365_010025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO365_010040	COG1253	flavin adenine dinucleotide binding
IXO365_010050	COG0306	phosphate transporter
IXO365_010080	COG0504	CTP synthase activity
IXO365_010085	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO365_010095	COG0148	phosphopyruvate hydratase activity
IXO365_010100	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO365_010105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO365_010115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO365_010125	COG2840	Smr protein MutS2
IXO365_010130	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO365_010135	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO365_010140	COG1238	metal cluster binding
IXO365_010155	COG1534	Rna-binding protein
IXO365_010160	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO365_010170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO365_010175	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO365_010185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO365_010190	COG1546	Belongs to the CinA family
IXO365_010205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO365_010210	COG2137	regulation of response to DNA damage stimulus
IXO365_010215	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO365_010220	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO365_010245	COG0305	Participates in initiation and elongation during chromosome replication
IXO365_010250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO365_010270	COG1741	Belongs to the pirin family
IXO365_010275	COG0583	DNA-binding transcription factor activity
IXO365_010305	COG0351	phosphomethylpyrimidine kinase
IXO365_010315	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO365_010320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO365_010335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO365_010345	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO365_010350	COG3734	2-keto-3-deoxy-galactonokinase
IXO365_010360	COG4948	Mandelate Racemase Muconate Lactonizing
IXO365_010365	COG0800	Aldolase
IXO365_010380	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO365_010390	COG1070	Carbohydrate kinase
IXO365_010400	COG0477	Major facilitator Superfamily
IXO365_010420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO365_010470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO365_010475	COG2258	MOSC domain
IXO365_010485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO365_010490	COG0505	Belongs to the CarA family
IXO365_010500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO365_010505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO365_010515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO365_010570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IXO365_010580	COG2198	Histidine kinase
IXO365_010580	COG0784	Response regulator, receiver
IXO365_010580	COG2205	protein histidine kinase activity
IXO365_010585	COG1024	Enoyl-CoA hydratase
IXO365_010590	COG0318	PFAM AMP-dependent synthetase and ligase
IXO365_010620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO365_010675	COG3039	Transposase
IXO365_010695	COG0835	chemotaxis
IXO365_010710	COG0840	transmembrane signaling receptor activity
IXO365_010715	COG0840	transmembrane signaling receptor activity
IXO365_010720	COG0840	transmembrane signaling receptor activity
IXO365_010725	COG0840	transmembrane signaling receptor activity
IXO365_010735	COG0840	transmembrane signaling receptor activity
IXO365_010745	COG0840	transmembrane signaling receptor activity
IXO365_010755	COG0840	transmembrane signaling receptor activity
IXO365_010775	COG0745	RESPONSE REGULATOR receiver
IXO365_010785	COG0835	chemotaxis
IXO365_010795	COG1360	Flagellar Motor Protein
IXO365_010800	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO365_010820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO365_010830	COG4771	TonB-dependent receptor
IXO365_010945	COG3039	Transposase
IXO365_010970	COG3039	Transposase
IXO365_010980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO365_010980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO365_010985	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO365_010990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO365_010990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO365_010995	COG1609	Transcriptional regulator
IXO365_011020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO365_011025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO365_011035	COG2902	Dehydrogenase
IXO365_011040	COG3039	Transposase
IXO365_011050	COG0784	Response regulator, receiver
IXO365_011050	COG2205	protein histidine kinase activity
IXO365_011050	COG5002	protein histidine kinase activity
IXO365_011055	COG2733	membrane
IXO365_011065	COG1121	(ABC) transporter
IXO365_011070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO365_011075	COG2223	nitrite transmembrane transporter activity
IXO365_011085	COG0243	molybdopterin cofactor binding
IXO365_011095	COG0477	Major facilitator Superfamily
IXO365_011105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO365_011110	COG0174	glutamine synthetase
IXO365_011190	COG3039	Transposase
IXO365_011200	COG0583	DNA-binding transcription factor activity
IXO365_011275	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO365_011280	COG0235	Class ii aldolase
IXO365_011285	COG0531	amino acid
IXO365_011290	COG0531	amino acid
IXO365_011300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO365_011305	COG0277	FAD linked oxidase domain protein
IXO365_011370	COG0436	Aminotransferase
IXO365_011395	COG1187	pseudouridine synthase activity
IXO365_011400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO365_011405	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO365_011410	COG2350	Protein conserved in bacteria
IXO365_011440	COG1175	transmembrane transport
IXO365_011445	COG0395	ABC-type sugar transport system, permease component
IXO365_011470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO365_011480	COG2957	Belongs to the agmatine deiminase family
IXO365_011495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO365_011500	COG0539	negative regulation of cytoplasmic translation
IXO365_011505	COG0776	regulation of translation
IXO365_011515	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO365_011520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO365_011530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO365_011550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO365_011565	COG0582	viral genome integration into host DNA
IXO365_011660	COG3002	Belongs to the UPF0753 family
IXO365_011665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO365_011670	COG0583	DNA-binding transcription factor activity
IXO365_011700	COG0583	DNA-binding transcription factor activity
IXO365_011705	COG0583	DNA-binding transcription factor activity
IXO365_011720	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO365_011740	COG0668	transmembrane transport
IXO365_011750	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IXO365_011765	COG1028	Short-chain dehydrogenase reductase Sdr
IXO365_011770	COG1183	phosphatidylcholine synthase activity
IXO365_011780	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO365_011795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO365_011795	COG0723	plastoquinol--plastocyanin reductase activity
IXO365_011805	COG2183	response to ionizing radiation
IXO365_011820	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO365_011835	COG0671	phosphoesterase, PA-phosphatase related
IXO365_011855	COG1794	racemase activity, acting on amino acids and derivatives
IXO365_011860	COG0697	spore germination
IXO365_011865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IXO365_011870	COG0167	dihydroorotate dehydrogenase activity
IXO365_011885	COG1012	belongs to the aldehyde dehydrogenase family
IXO365_011920	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO365_011935	COG0124	histidyl-tRNA synthetase
IXO365_011955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO365_011970	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO365_011970	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO365_011980	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO365_011990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO365_011990	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO365_012030	COG0653	protein targeting
IXO365_012055	COG3039	Transposase
IXO365_012115	COG2201	protein-glutamate methylesterase activity
IXO365_012125	COG2801	Transposase and inactivated derivatives
IXO365_012140	COG3039	Transposase
IXO365_012160	COG3328	transposase activity
IXO365_012195	COG0322	excinuclease ABC activity
IXO365_012205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO365_012215	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO365_012230	COG0811	peptide transport
IXO365_012255	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO365_012270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO365_012285	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO365_012300	COG0354	folic acid binding
IXO365_012315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO365_012325	COG0363	glucosamine-6-phosphate deaminase activity
IXO365_012330	COG0129	dihydroxy-acid dehydratase activity
IXO365_012335	COG0800	Aldolase
IXO365_012375	COG5002	protein histidine kinase activity
IXO365_012375	COG0784	Response regulator, receiver
IXO365_012375	COG2205	protein histidine kinase activity
IXO365_012390	COG3039	Transposase
IXO365_012460	COG0386	Belongs to the glutathione peroxidase family
IXO365_012545	COG4251	negative regulation of phosphorylation
IXO365_012545	COG3706	GGDEF domain
IXO365_012545	COG2203	Gaf domain
IXO365_012545	COG5001	Diguanylate cyclase
IXO365_012560	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO365_012590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO365_012595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO365_012605	COG0617	tRNA 3'-terminal CCA addition
IXO365_012615	COG1469	GTP cyclohydrolase I activity
IXO365_012620	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO365_012665	COG4566	intracellular signal transduction
IXO365_012675	COG3039	Transposase
IXO365_012700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO365_012705	COG1605	Chorismate mutase
IXO365_012705	COG0077	Prephenate dehydratase
IXO365_012715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO365_012755	COG1228	amidohydrolase
IXO365_012760	COG2986	histidine ammonia-lyase
IXO365_012770	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO365_012795	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO365_012810	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO365_012830	COG3115	cell septum assembly
IXO365_012840	COG0359	binds to the 23S rRNA
IXO365_012850	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO365_012855	COG0316	Belongs to the HesB IscA family
IXO365_012885	COG0288	reversible hydration of carbon dioxide
IXO365_012920	COG2925	Exonuclease
IXO365_012930	COG0667	Aldo Keto reductase
IXO365_012955	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO365_012955	COG0116	Belongs to the methyltransferase superfamily
IXO365_013000	COG0494	nUDIX hydrolase
IXO365_013015	COG1024	Enoyl-CoA hydratase
IXO365_013025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO365_013045	COG3039	Transposase
IXO365_013085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO365_013090	COG0573	inorganic phosphate transmembrane transporter activity
IXO365_013105	COG0704	Plays a role in the regulation of phosphate uptake
IXO365_013115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO365_013150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO365_013155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO365_013160	COG1862	Preprotein translocase
IXO365_013165	COG0343	queuine tRNA-ribosyltransferase activity
IXO365_013215	COG3039	Transposase
IXO365_013250	COG3039	Transposase
IXO365_013275	COG0405	Gamma-glutamyltransferase
IXO365_013280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO365_013290	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO365_013295	COG0742	ribosomal rna small subunit methyltransferase
IXO365_013335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO365_013390	COG0303	'Molybdopterin
IXO365_013400	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO365_013410	COG1426	Protein conserved in bacteria
IXO365_013420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO365_013435	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO365_013435	COG1024	Enoyl-CoA hydratase
IXO365_013440	COG0183	Belongs to the thiolase family
IXO365_013445	COG0038	chloride channel
IXO365_013465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO365_013485	COG1674	ftsk spoiiie
IXO365_013490	COG0492	ferredoxin-NADP+ reductase activity
IXO365_013515	COG0542	response to heat
IXO365_013530	COG0482	sulfurtransferase activity
IXO365_013555	COG5001	Diguanylate cyclase
IXO365_013560	COG4585	Histidine kinase
IXO365_013570	COG5002	protein histidine kinase activity
IXO365_013590	COG0835	chemotaxis
IXO365_013590	COG0784	Response regulator, receiver
IXO365_013600	COG1558	bacterial-type flagellum-dependent cell motility
IXO365_013605	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO365_013615	COG4787	bacterial-type flagellum-dependent cell motility
IXO365_013650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO365_013655	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO365_013685	COG2201	protein-glutamate methylesterase activity
IXO365_013705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO365_013715	COG1028	Short-chain dehydrogenase reductase Sdr
IXO365_013745	COG1677	Flagellar hook-basal body complex protein FliE
IXO365_013795	COG3190	flagellar
IXO365_013810	COG1684	flagellar biosynthetic protein fliR
IXO365_013865	COG0784	Response regulator, receiver
IXO365_013865	COG0643	Histidine kinase
IXO365_013865	COG2198	Histidine kinase
IXO365_013890	COG3039	Transposase
IXO365_013925	COG3209	COG3209 Rhs family protein
IXO365_013940	COG3039	Transposase
IXO365_014025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO365_014030	COG4988	ABC transporter
IXO365_014040	COG1271	oxidase subunit
IXO365_014070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO365_014090	COG0165	Argininosuccinate lyase
IXO365_014105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO365_014110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO365_014120	COG0137	argininosuccinate synthase activity
IXO365_014125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO365_014140	COG2166	iron-sulfur cluster assembly
IXO365_014165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO365_014200	COG3039	Transposase
IXO365_014210	COG4677	pectinesterase activity
IXO365_014235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO365_014240	COG0402	S-adenosylhomocysteine deaminase activity
IXO365_014255	COG1509	lysine 2,3-aminomutase activity
IXO365_014260	COG5001	Diguanylate cyclase
IXO365_014260	COG3300	MHYT domain
IXO365_014275	COG0483	inositol monophosphate 1-phosphatase activity
IXO365_014280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO365_014300	COG0488	(ABC) transporter
IXO365_014305	COG0513	Belongs to the DEAD box helicase family
IXO365_014310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO365_014315	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IXO365_014325	COG0625	glutathione transferase activity
IXO365_014335	COG1671	Belongs to the UPF0178 family
IXO365_014340	COG4681	YaeQ
IXO365_014345	COG2081	HI0933 family
IXO365_014355	COG0501	Belongs to the peptidase M48B family
IXO365_014365	COG1028	Short-chain dehydrogenase reductase Sdr
IXO365_014385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO365_014390	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO365_014395	COG0802	atpase or kinase
IXO365_014400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO365_014400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO365_014405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO365_014425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO365_014510	COG3328	transposase activity
IXO365_014545	COG2969	positive regulation of protein catabolic process
IXO365_014550	COG0625	glutathione transferase activity
IXO365_014555	COG2857	Cytochrome c1
IXO365_014560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO365_014565	COG0723	plastoquinol--plastocyanin reductase activity
IXO365_014570	COG0741	lytic transglycosylase activity
IXO365_014595	COG1702	phosphate starvation-inducible protein PhoH
IXO365_014615	COG4535	Mg2 and Co2 transporter CorC
IXO365_014630	COG1012	belongs to the aldehyde dehydrogenase family
IXO365_014640	COG1177	transmembrane transport
IXO365_014650	COG3842	ATPase activity
IXO365_014720	COG3039	Transposase
IXO365_014730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO365_014750	COG0557	exoribonuclease II activity
IXO365_014775	COG1960	acyl-CoA dehydrogenase activity
IXO365_014780	COG2226	methyltransferase
IXO365_014785	COG1410	methionine synthase
IXO365_014785	COG0646	methionine synthase
IXO365_014790	COG1410	methionine synthase
IXO365_014790	COG0646	methionine synthase
IXO365_014800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO365_014810	COG1609	Transcriptional regulator
IXO365_014825	COG2900	Belongs to the SlyX family
IXO365_014840	COG0386	Belongs to the glutathione peroxidase family
IXO365_014850	COG1725	Transcriptional regulator
IXO365_014855	COG1131	(ABC) transporter
IXO365_014935	COG2850	peptidyl-arginine hydroxylation
IXO365_014970	COG1132	(ABC) transporter
IXO365_014985	COG0583	DNA-binding transcription factor activity
IXO365_015000	COG0287	Prephenate dehydrogenase
IXO365_015000	COG1605	Chorismate mutase
IXO365_015005	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO365_015010	COG0484	heat shock protein binding
IXO365_015020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO365_015030	COG0497	DNA recombination
IXO365_015040	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO365_015045	COG2914	Belongs to the UPF0125 (RnfH) family
IXO365_015055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO365_015070	COG1960	acyl-CoA dehydrogenase activity
IXO365_015080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO365_015135	COG2814	Major facilitator Superfamily
IXO365_015140	COG1566	PFAM secretion protein HlyD family protein
IXO365_015190	COG4774	siderophore transport
IXO365_015200	COG0367	asparagine synthase
IXO365_015205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO365_015215	COG1393	Belongs to the ArsC family
IXO365_015275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO365_015290	COG0233	cytoplasmic translational termination
IXO365_015300	COG0575	Belongs to the CDS family
IXO365_015310	COG0750	zinc metalloprotease
IXO365_015325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO365_015330	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO365_015350	COG0825	malonyl-CoA metabolic process
IXO365_015360	COG4771	TonB-dependent receptor
IXO365_015385	COG1981	membrane
IXO365_015430	COG2895	sulfate adenylyltransferase (ATP) activity
IXO365_015430	COG0529	Catalyzes the synthesis of activated sulfate
IXO365_015470	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO365_015485	COG2040	homocysteine
IXO365_015490	COG0833	amino acid
IXO365_015510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO365_015510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO365_015520	COG2878	Part of a membrane complex involved in electron transport
IXO365_015535	COG1595	DNA-templated transcription, initiation
IXO365_015560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO365_015575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO365_015580	COG0251	oxidation-reduction process
IXO365_015590	COG0392	lysyltransferase activity
IXO365_015590	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO365_015620	COG3039	Transposase
IXO365_015645	COG2814	Major facilitator Superfamily
IXO365_015650	COG1902	pentaerythritol trinitrate reductase activity
IXO365_015660	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO365_015675	COG1047	Peptidyl-prolyl cis-trans
IXO365_015710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO365_015725	COG1451	nucleotide metabolic process
IXO365_015730	COG3039	Transposase
IXO365_015750	COG0183	Belongs to the thiolase family
IXO365_015780	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO365_015780	COG1793	dna ligase
IXO365_015790	COG1793	dna ligase
IXO365_015795	COG1201	RNA secondary structure unwinding
IXO365_015815	COG1278	Cold shock
IXO365_015820	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO365_015825	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO365_015835	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO365_015840	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IXO365_015845	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO365_015850	COG3039	Transposase
IXO365_015860	COG2954	triphosphatase activity
IXO365_015875	COG1381	Involved in DNA repair and RecF pathway recombination
IXO365_015900	COG0481	GTPase activity
IXO365_015905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO365_015920	COG1024	Enoyl-CoA hydratase
IXO365_015920	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO365_015945	COG1024	Enoyl-CoA hydratase
IXO365_015950	COG1960	acyl-CoA dehydrogenase activity
IXO365_015975	COG3250	beta-galactosidase activity
IXO365_016020	COG2353	YceI-like domain
IXO365_016030	COG2353	YceI-like domain
IXO365_016045	COG1760	l-serine dehydratase
IXO365_016055	COG0626	cystathionine gamma-synthase activity
IXO365_016060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO365_016065	COG0739	heme binding
IXO365_016075	COG1272	protein, Hemolysin III
IXO365_016095	COG0463	Glycosyl transferase, family 2
IXO365_016105	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO365_016115	COG4771	TonB-dependent receptor
IXO365_016120	COG1309	transcriptional regulator
IXO365_016130	COG1960	acyl-CoA dehydrogenase activity
IXO365_016150	COG3039	Transposase
IXO365_016165	COG0509	glycine decarboxylation via glycine cleavage system
IXO365_016180	COG0330	HflC and HflK could
IXO365_016195	COG3956	TIGRFAM MazG family protein
IXO365_016205	COG0494	nUDIX hydrolase
IXO365_016215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO365_016220	COG0837	glucose binding
IXO365_016235	COG1388	LysM domain
IXO365_016235	COG3858	chitin binding
IXO365_016245	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO365_016255	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO365_016295	COG3537	Alpha-1,2-mannosidase
IXO365_016340	COG1446	asparaginase
IXO365_016365	COG3039	Transposase
IXO365_016385	COG0643	Histidine kinase
IXO365_016385	COG0784	Response regulator, receiver
IXO365_016385	COG2198	Histidine kinase
IXO365_016390	COG0840	transmembrane signaling receptor activity
IXO365_016395	COG0835	chemotaxis
IXO365_016410	COG0189	ligase activity
IXO365_016420	COG1397	ADP-ribosylglycohydrolase
IXO365_016430	COG1199	ATP-dependent helicase activity
IXO365_016440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO365_016445	COG1215	transferase activity, transferring glycosyl groups
IXO365_016455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO365_016475	COG0535	radical SAM domain protein
IXO365_016480	COG0535	radical SAM domain protein
IXO365_016510	COG1643	Atp-dependent helicase
IXO365_016515	COG0783	Belongs to the Dps family
IXO365_016520	COG0514	ATP-dependent DNA helicase (RecQ)
IXO365_016590	COG4695	Portal protein
IXO365_016635	COG3179	chitinase
IXO365_016815	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO365_016875	COG1187	pseudouridine synthase activity
IXO365_016880	COG0602	queuosine metabolic process
IXO365_016890	COG2885	chlorophyll binding
IXO365_016905	COG0848	biopolymer transport protein
IXO365_016915	COG0824	Thioesterase
IXO365_016920	COG2255	four-way junction helicase activity
IXO365_016930	COG0632	four-way junction helicase activity
IXO365_017040	COG3328	transposase activity
IXO365_017050	COG3209	COG3209 Rhs family protein
IXO365_017070	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO365_017075	COG1845	cytochrome c oxidase, subunit III
IXO365_017080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO365_017095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO365_017100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO365_017110	COG0196	riboflavin kinase activity
IXO365_017115	COG0728	peptidoglycan biosynthetic process
IXO365_017120	COG0268	Binds directly to 16S ribosomal RNA
IXO365_017125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO365_017130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO365_017140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO365_017145	COG0824	Thioesterase
IXO365_017160	COG1946	Acyl-CoA thioesterase
IXO365_017170	COG1595	DNA-templated transcription, initiation
IXO365_017185	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO365_017220	COG1877	trehalose-phosphatase activity
IXO365_017225	COG3387	PFAM Glycoside hydrolase 15-related
IXO365_017250	COG0564	pseudouridine synthase activity
IXO365_017255	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO365_017260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO365_017260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO365_017270	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO365_017275	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO365_017315	COG2194	sulfuric ester hydrolase activity
IXO365_017320	COG4969	Belongs to the N-Me-Phe pilin family
IXO365_017330	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO365_017360	COG3039	Transposase
IXO365_017390	COG1132	(ABC) transporter
IXO365_017420	COG0745	RESPONSE REGULATOR receiver
IXO365_017425	COG5000	phosphorelay sensor kinase activity
IXO365_017425	COG5002	protein histidine kinase activity
IXO365_017430	COG0475	glutathione-regulated potassium exporter activity
IXO365_017440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO365_017460	COG1187	pseudouridine synthase activity
IXO365_017465	COG5002	protein histidine kinase activity
IXO365_017465	COG5001	Diguanylate cyclase
IXO365_017565	COG1028	Short-chain dehydrogenase reductase Sdr
IXO365_017580	COG0415	Belongs to the DNA photolyase family
IXO365_017585	COG0305	Participates in initiation and elongation during chromosome replication
IXO365_017595	COG0367	asparagine synthase
IXO365_017610	COG1960	acyl-CoA dehydrogenase activity
IXO365_017625	COG0084	hydrolase, TatD family'
IXO365_017630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO365_017690	COG0735	belongs to the Fur family
IXO365_017695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO365_017720	COG3039	Transposase
IXO365_017770	COG2205	protein histidine kinase activity
IXO365_017780	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO365_017790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO365_017805	COG0643	Histidine kinase
IXO365_017805	COG2198	Histidine kinase
IXO365_017810	COG0840	transmembrane signaling receptor activity
IXO365_017815	COG0835	chemotaxis
IXO365_017820	COG2199	diguanylate cyclase activity
IXO365_017820	COG2200	EAL domain
IXO365_017820	COG2202	Pas domain
IXO365_017825	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO365_017840	COG3590	peptidase
IXO365_017855	COG0588	phosphoglycerate mutase activity
IXO365_017860	COG1515	deoxyribonuclease V activity
IXO365_017870	COG1741	Belongs to the pirin family
IXO365_017955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO365_017965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO365_018060	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO365_018075	COG2197	response regulator
IXO365_018080	COG4585	Histidine kinase
IXO365_018095	COG2894	cell division
IXO365_018100	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO365_018110	COG0642	Histidine kinase
IXO365_018115	COG0745	RESPONSE REGULATOR receiver
IXO365_018120	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO365_018130	COG2194	sulfuric ester hydrolase activity
IXO365_018160	COG3551	Protein conserved in bacteria
IXO365_018220	COG0203	ribosomal protein L17
IXO365_018230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO365_018235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO365_018245	COG0201	protein transport
IXO365_018255	COG1841	ribosomal large subunit assembly
IXO365_018265	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IXO365_018285	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO365_018295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO365_018300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO365_018305	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO365_018310	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO365_018320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO365_018335	COG0089	rRNA binding
IXO365_018340	COG0088	Forms part of the polypeptide exit tunnel
IXO365_018345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO365_018350	COG0051	transcription antitermination factor activity, RNA binding
IXO365_018370	COG0049	tRNA binding
IXO365_018375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO365_018380	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO365_018385	COG0085	RNA polymerase activity
IXO365_018390	COG0222	ribosome binding
IXO365_018395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO365_018405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO365_018410	COG0250	Participates in transcription elongation, termination and antitermination
IXO365_018415	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO365_018445	COG0012	GTP binding
IXO365_018450	COG0193	aminoacyl-tRNA hydrolase activity
IXO365_018460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO365_018475	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO365_018485	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO365_018490	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO365_018505	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO365_018525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO365_018530	COG1295	ribonuclease BN
IXO365_018560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO365_018565	COG1404	Belongs to the peptidase S8 family
IXO365_018570	COG1404	Belongs to the peptidase S8 family
IXO365_018580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO365_018605	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO365_018630	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO365_018645	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO365_018645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO365_018695	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO365_018705	COG3634	alkyl hydroperoxide reductase activity
IXO365_018710	COG0583	DNA-binding transcription factor activity
IXO365_018720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO365_018745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO365_018780	COG0584	glycerophosphoryl diester phosphodiesterase
IXO365_018800	COG3039	Transposase
IXO365_018815	COG0625	glutathione transferase activity
IXO365_018820	COG0039	L-malate dehydrogenase activity
IXO365_018825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO365_018830	COG1217	gtp-binding protein TYPA
IXO365_018850	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO365_018985	COG3781	membrane
IXO365_018995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO365_019025	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO365_019045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO365_019070	COG3710	Transcriptional regulator
IXO365_019075	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO365_019085	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO365_019115	COG2226	methyltransferase
IXO365_019120	COG0066	3-isopropylmalate dehydratase activity
IXO365_019125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO365_019155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO365_019160	COG1538	Outer membrane efflux protein
IXO365_019165	COG1519	Transferase
IXO365_019170	COG1560	Kdo2-lipid A biosynthetic process
IXO365_019225	COG0308	aminopeptidase N
IXO365_019230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO365_019240	COG0330	HflC and HflK could
IXO365_019245	COG0330	HflC and HflK could
IXO365_019265	COG0678	peroxiredoxin activity
IXO365_019275	COG2826	transposase and inactivated derivatives, IS30 family
IXO365_019305	COG3039	Transposase
IXO365_019335	COG3829	transcription factor binding
IXO365_019370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO365_019375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO365_019385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO365_019390	COG1028	Short-chain dehydrogenase reductase Sdr
IXO365_019415	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO365_019430	COG3039	Transposase
IXO365_019470	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO365_019520	COG2188	Transcriptional regulator
IXO365_019535	COG1450	Type ii and iii secretion system protein
IXO365_019550	COG3166	PFAM Fimbrial assembly family protein
IXO365_019555	COG3156	type II secretion system protein K
IXO365_019560	COG4795	General secretion pathway protein
IXO365_019565	COG2165	general secretion pathway protein
IXO365_019570	COG4970	Tfp pilus assembly protein FimT
IXO365_019575	COG2165	general secretion pathway protein
IXO365_019580	COG1459	type II secretion system
IXO365_019590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO365_019600	COG1404	Belongs to the peptidase S8 family
IXO365_019610	COG5295	Hep Hag repeat protein
IXO365_019615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXO365_019615	COG0047	phosphoribosylformylglycinamidine synthase activity
IXO365_019620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO365_019625	COG4974	Belongs to the 'phage' integrase family
IXO365_019635	COG0795	lipopolysaccharide-transporting ATPase activity
IXO365_019645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO365_019660	COG0525	valine-tRNA ligase activity
IXO365_019695	COG3039	Transposase
IXO365_019730	COG3039	Transposase
IXO365_019760	COG1183	phosphatidylcholine synthase activity
IXO365_019770	COG0442	prolyl-tRNA aminoacylation
IXO365_019785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO365_019790	COG1127	ABC transporter
IXO365_019795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO365_019795	COG3218	ABC-type transport auxiliary lipoprotein component
IXO365_019830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO365_019835	COG0662	Cupin 2, conserved barrel domain protein
IXO365_019835	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO365_019860	COG2086	electron transfer activity
IXO365_019885	COG3328	transposase activity
IXO365_019925	COG0626	cystathionine gamma-synthase activity
IXO365_019955	COG0625	glutathione transferase activity
IXO365_019965	COG0513	Belongs to the DEAD box helicase family
IXO365_019970	COG0720	synthase
IXO365_019980	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO365_019985	COG1956	GAF domain-containing protein
IXO365_020020	COG0339	signal peptide processing
IXO365_020070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO365_020075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO365_020125	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXO365_020130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO365_020135	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO365_020140	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO365_020150	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO365_020160	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO365_020180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO365_020190	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO365_020220	COG2011	ABC-type metal ion transport system permease component
IXO365_020230	COG0697	spore germination
IXO365_020265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO365_020270	COG1187	pseudouridine synthase activity
IXO365_020275	COG2813	Specifically methylates the guanine in position
IXO365_020305	COG2205	protein histidine kinase activity
IXO365_020305	COG2202	Pas domain
IXO365_020330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO365_020380	COG0745	RESPONSE REGULATOR receiver
IXO365_020395	COG1404	Belongs to the peptidase S8 family
IXO365_020415	COG0842	Transport permease protein
IXO365_020420	COG1131	(ABC) transporter
IXO365_020425	COG0025	NhaP-type Na H and K H
IXO365_020440	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO365_020450	COG1573	uracil-dna glycosylase
IXO365_020460	COG3384	dioxygenase
IXO365_020475	COG0667	Aldo Keto reductase
IXO365_020490	COG3590	peptidase
IXO365_020510	COG0531	amino acid
IXO365_020535	COG2972	Histidine kinase
IXO365_020585	COG1271	oxidase subunit
IXO365_020740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO365_020750	COG1560	Kdo2-lipid A biosynthetic process
IXO365_020800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO365_020800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO365_020805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO365_020810	COG0242	peptide deformylase activity
IXO365_020815	COG1652	LysM domain
IXO365_020820	COG0758	DNA mediated transformation
IXO365_020825	COG2922	Belongs to the Smg family
IXO365_020840	COG1754	DNA topoisomerase type I activity
IXO365_020840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO365_020845	COG0009	L-threonylcarbamoyladenylate synthase
IXO365_020860	COG1028	Short-chain dehydrogenase reductase Sdr
IXO365_020870	COG0616	signal peptide processing
IXO365_020875	COG0534	Mate efflux family protein
IXO365_020895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO365_020930	COG1324	tolerance protein
IXO365_020940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO365_020945	COG0511	ligase activity, forming carbon-carbon bonds
IXO365_020955	COG0439	Biotin carboxylase
IXO365_021000	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO365_021060	COG3039	Transposase
IXO365_021085	COG3039	Transposase
IXO365_021150	COG3210	domain, Protein
IXO365_021155	COG2831	hemolysin activation secretion protein
IXO365_021185	COG2267	carboxylic ester hydrolase activity
IXO365_021190	COG2267	carboxylic ester hydrolase activity
IXO365_021200	COG0138	bifunctional purine biosynthesis protein purh
IXO365_021210	COG0151	Belongs to the GarS family
IXO365_021235	COG1289	transmembrane transporter activity
IXO365_021250	COG2814	Major facilitator Superfamily
IXO365_021265	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO365_021300	COG0745	RESPONSE REGULATOR receiver
IXO365_021345	COG0739	heme binding
IXO365_021360	COG2211	Major facilitator Superfamily
IXO365_021365	COG0708	Exodeoxyribonuclease III
IXO365_021380	COG1192	Involved in chromosome partitioning
IXO365_021385	COG1475	DNA binding
IXO365_021400	COG0463	Glycosyl transferase, family 2
IXO365_021425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO365_021435	COG0018	arginyl-trna synthetase
IXO365_021450	COG4221	oxidoreductase activity
IXO365_021475	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO365_021480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO365_021495	COG3485	protocatechuate 3,4-dioxygenase
IXO365_021500	COG3485	protocatechuate 3,4-dioxygenase
IXO365_021535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO365_021540	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO365_021550	COG1042	CoA-binding domain protein
IXO365_021550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO365_021550	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO365_021565	COG2239	Acts as a magnesium transporter
IXO365_021580	COG3039	Transposase
IXO365_021590	COG3328	transposase activity
IXO365_021595	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO365_021595	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO365_021605	COG1473	amidohydrolase
IXO365_021610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO365_021615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO365_021625	COG5383	Protein conserved in bacteria
IXO365_021650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO365_021655	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO365_021670	COG0028	Belongs to the TPP enzyme family
IXO365_021675	COG4191	Histidine kinase
IXO365_021700	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO365_021715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO365_021720	COG3177	Filamentation induced by cAMP protein fic
IXO365_021735	COG0596	Alpha beta hydrolase
IXO365_021740	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO365_021745	COG0318	PFAM AMP-dependent synthetase and ligase
IXO365_021750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO365_021800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO365_021810	COG0129	dihydroxy-acid dehydratase activity
IXO365_021830	COG3039	Transposase
IXO365_021840	COG0408	coproporphyrinogen oxidase activity
IXO365_021880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXO365_021900	COG2201	protein-glutamate methylesterase activity
IXO365_021940	COG2353	YceI-like domain
IXO365_021970	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO365_021985	COG3386	PFAM SMP-30 Gluconolaconase
IXO365_022025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO365_022045	COG0459	protein refolding
IXO365_022070	COG1252	NADH dehydrogenase
IXO365_022080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO365_022085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO365_022090	COG2201	protein-glutamate methylesterase activity
IXO365_022095	COG2177	Part of the ABC transporter FtsEX involved in
IXO365_022100	COG2884	Cell division ATP-binding protein ftsE
IXO365_022110	COG3118	belongs to the thioredoxin family
IXO365_022115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO365_022130	COG0729	surface antigen
IXO365_022135	COG2911	Protein conserved in bacteria
IXO365_022170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO365_022185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO365_022235	COG1733	regulation of RNA biosynthetic process
IXO365_022240	COG0702	epimerase
IXO365_022270	COG0583	DNA-binding transcription factor activity
IXO365_022275	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO365_022295	COG0745	RESPONSE REGULATOR receiver
IXO365_022325	COG1902	pentaerythritol trinitrate reductase activity
IXO365_022330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO365_022340	COG2814	Major facilitator Superfamily
IXO365_022345	COG0583	DNA-binding transcription factor activity
IXO365_022360	COG0084	hydrolase, TatD family'
IXO365_022405	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO365_022425	COG2072	flavoprotein involved in K transport
IXO365_022485	COG4770	biotin carboxylase activity
IXO365_022490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO365_022495	COG1960	acyl-CoA dehydrogenase activity
IXO365_022545	COG0523	cobalamin synthesis protein
IXO365_022555	COG0697	spore germination
IXO365_022565	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO365_022580	COG4771	TonB-dependent receptor
IXO365_022585	COG0457	Tetratricopeptide repeat
IXO365_022595	COG0752	glycyl-tRNA synthetase alpha subunit
IXO365_022600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO365_022615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO365_022615	COG0519	Catalyzes the synthesis of GMP from XMP
IXO365_022625	COG0805	protein transport
IXO365_022635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO365_022645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO365_022665	COG2974	May be involved in recombination
IXO365_022670	COG0037	tRNA processing
IXO365_022685	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO365_022695	COG4948	Mandelate Racemase Muconate Lactonizing
IXO365_022705	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO365_022710	COG0246	Mannitol dehydrogenase
IXO365_022735	COG3693	PFAM glycoside hydrolase, family 10
IXO365_022755	COG2211	Major facilitator Superfamily
IXO365_022800	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IXO365_022840	COG1846	Transcriptional regulator
IXO365_022845	COG1764	response to oxidative stress
IXO365_022920	COG3549	Plasmid maintenance system killer
IXO365_022930	COG1074	ATP-dependent DNA helicase activity
IXO365_022935	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO365_022980	COG2032	superoxide dismutase activity
IXO365_022985	COG2032	superoxide dismutase activity
IXO365_022990	COG2204	response regulator
IXO365_022995	COG3852	Histidine kinase
IXO365_023000	COG0004	ammonium transporteR
IXO365_023005	COG0347	Belongs to the P(II) protein family
IXO365_023010	COG0174	glutamine synthetase
IXO365_023015	COG1968	undecaprenyl-diphosphatase activity
IXO365_023060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO365_023070	COG2062	phosphohistidine phosphatase, SixA
IXO365_023075	COG0489	protein tyrosine kinase activity
IXO365_023095	COG1396	sequence-specific DNA binding
IXO365_023100	COG3550	peptidyl-serine autophosphorylation
IXO365_023105	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO365_023110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO365_023125	COG0517	IMP dehydrogenase activity
IXO365_023125	COG1125	glycine betaine transport
IXO365_023140	COG1119	ATPase activity
IXO365_023150	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO365_023165	COG3039	Transposase
IXO365_023190	COG0656	L-ascorbic acid biosynthetic process
IXO365_023195	COG2130	NADP-dependent
IXO365_023200	COG0667	Aldo Keto reductase
IXO365_023210	COG1187	pseudouridine synthase activity
IXO365_023220	COG1643	Atp-dependent helicase
IXO365_023225	COG4807	Protein conserved in bacteria
IXO365_023230	COG4948	Mandelate Racemase Muconate Lactonizing
IXO365_023235	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO365_023240	COG1028	Short-chain dehydrogenase reductase Sdr
IXO365_023260	COG3507	Belongs to the glycosyl hydrolase 43 family
IXO365_023300	COG3162	membrane
IXO365_023305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO365_023325	COG0708	Exodeoxyribonuclease III
IXO365_023340	COG2091	lysine biosynthetic process via aminoadipic acid
IXO365_023350	COG3540	Alkaline phosphatase
IXO365_023355	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO365_023380	COG2159	amidohydrolase
IXO365_023390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO365_023395	COG0583	DNA-binding transcription factor activity
IXO365_023400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO365_023415	COG0210	DNA helicase
IXO365_023440	COG0531	amino acid
IXO365_023445	COG1322	Protein conserved in bacteria
IXO365_023455	COG0386	Belongs to the glutathione peroxidase family
IXO365_023515	COG0793	Belongs to the peptidase S41A family
IXO365_023520	COG4942	peptidase
IXO365_023530	COG2234	aminopeptidase activity
IXO365_023575	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO365_023580	COG0302	gtp cyclohydrolase
IXO365_023600	COG0477	Major facilitator Superfamily
IXO365_023720	COG3039	Transposase
IXO365_023730	COG1929	Belongs to the glycerate kinase type-1 family
IXO365_023735	COG2271	Major facilitator Superfamily
IXO365_023750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO365_023755	COG0861	Integral membrane protein TerC family
IXO365_023770	COG0584	glycerophosphoryl diester phosphodiesterase
IXO365_023780	COG0671	phosphoesterase, PA-phosphatase related
IXO365_023790	COG0726	polysaccharide deacetylase
IXO365_023795	COG0706	membrane insertase activity