locus-tag	class	description
IXO493_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO493_000020	COG0187	DNA topoisomerase II activity
IXO493_000030	COG0501	Belongs to the peptidase M48B family
IXO493_000060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO493_000070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO493_000080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO493_000090	COG4772	TonB-dependent receptor
IXO493_000110	COG1304	FMN binding
IXO493_000140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO493_000225	COG2826	transposase and inactivated derivatives, IS30 family
IXO493_000250	COG3039	Transposase
IXO493_000260	COG1090	epimerase
IXO493_000270	COG0642	Histidine kinase
IXO493_000280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO493_000385	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO493_000460	COG3264	Mechanosensitive ion channel
IXO493_000460	COG1511	domain protein
IXO493_000475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO493_000480	COG2354	Protein conserved in bacteria
IXO493_000485	COG1649	PFAM Uncharacterised BCR, COG1649
IXO493_000505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO493_000530	COG0702	epimerase
IXO493_000545	COG1858	cytochrome C peroxidase
IXO493_000620	COG0513	Belongs to the DEAD box helicase family
IXO493_000625	COG3039	Transposase
IXO493_000670	COG1136	(ABC) transporter
IXO493_000710	COG1136	(ABC) transporter
IXO493_000750	COG1272	protein, Hemolysin III
IXO493_000755	COG1111	helicase
IXO493_000755	COG1205	dead DEAH box helicase
IXO493_000815	COG0069	glutamate synthase activity
IXO493_000815	COG0070	glutamate synthase
IXO493_000815	COG0067	glutamate synthase
IXO493_000820	COG0493	'glutamate synthase
IXO493_000865	COG1609	Transcriptional regulator
IXO493_000890	COG0366	Alpha amylase catalytic
IXO493_000895	COG0366	Alpha amylase catalytic
IXO493_000935	COG0606	chelatase, subunit chli
IXO493_000975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO493_000980	COG1166	arginine decarboxylase activity
IXO493_001055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO493_001080	COG1028	Short-chain dehydrogenase reductase Sdr
IXO493_001105	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO493_001120	COG0210	DNA helicase
IXO493_001135	COG3132	Protein of unknown function, DUF480
IXO493_001140	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO493_001145	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO493_001180	COG2937	Belongs to the GPAT DAPAT family
IXO493_001185	COG1028	Short-chain dehydrogenase reductase Sdr
IXO493_001185	COG0604	alcohol dehydrogenase
IXO493_001185	COG3321	synthase
IXO493_001220	COG3186	Phenylalanine-4-hydroxylase
IXO493_001225	COG1522	sequence-specific DNA binding
IXO493_001270	COG1064	alcohol dehydrogenase
IXO493_001275	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO493_001280	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO493_001290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO493_001310	COG0676	glucose-6-phosphate 1-epimerase activity
IXO493_001375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO493_001395	COG2853	Lipoprotein
IXO493_001410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO493_001415	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO493_001420	COG1127	ABC transporter
IXO493_001495	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO493_001500	COG3265	gluconokinase activity
IXO493_001505	COG2211	Major facilitator Superfamily
IXO493_001510	COG3459	Glycosyltransferase 36 associated
IXO493_001520	COG2205	protein histidine kinase activity
IXO493_001530	COG1414	Transcriptional regulator
IXO493_001535	COG0738	Major facilitator superfamily
IXO493_001540	COG3254	rhamnose metabolic process
IXO493_001570	COG0339	signal peptide processing
IXO493_001600	COG0564	pseudouridine synthase activity
IXO493_001610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO493_001620	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO493_001660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO493_001670	COG0842	Transport permease protein
IXO493_001675	COG1131	(ABC) transporter
IXO493_001705	COG1476	TRANSCRIPTIONal
IXO493_001715	COG4555	ABC transporter
IXO493_001750	COG0625	glutathione transferase activity
IXO493_001795	COG0583	DNA-binding transcription factor activity
IXO493_001835	COG1199	ATP-dependent helicase activity
IXO493_001855	COG1566	PFAM secretion protein HlyD family protein
IXO493_001875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO493_001915	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO493_001915	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO493_001920	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO493_001935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO493_001970	COG3237	CsbD-like
IXO493_001975	COG0180	Tryptophanyl-tRNA synthetase
IXO493_001980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO493_002025	COG0753	catalase activity
IXO493_002030	COG1595	DNA-templated transcription, initiation
IXO493_002040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO493_002050	COG0628	permease
IXO493_002060	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO493_002065	COG1040	competence protein
IXO493_002070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO493_002075	COG0156	8-amino-7-oxononanoate synthase activity
IXO493_002085	COG1028	Short-chain dehydrogenase reductase Sdr
IXO493_002100	COG0463	Glycosyl transferase, family 2
IXO493_002110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO493_002115	COG3100	YcgL domain-containing protein
IXO493_002130	COG3387	PFAM Glycoside hydrolase 15-related
IXO493_002135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO493_002140	COG3039	Transposase
IXO493_002200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO493_002215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO493_002220	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO493_002230	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO493_002235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO493_002240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO493_002290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO493_002305	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO493_002370	COG0358	DNA primase activity
IXO493_002375	COG1295	ribonuclease BN
IXO493_002385	COG1610	YqeY-like protein
IXO493_002395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO493_002400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO493_002440	COG2133	pyrroloquinoline quinone binding
IXO493_002445	COG4682	membrane
IXO493_002470	COG0531	amino acid
IXO493_002500	COG4948	Mandelate Racemase Muconate Lactonizing
IXO493_002510	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO493_002515	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO493_002585	COG0183	Belongs to the thiolase family
IXO493_002625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IXO493_002635	COG3483	tryptophan 2,3-dioxygenase activity
IXO493_002640	COG3104	oligopeptide transport
IXO493_002670	COG1320	monovalent cation:proton antiporter activity
IXO493_002675	COG2212	antiporter activity
IXO493_002685	COG0651	ATP synthesis coupled electron transport
IXO493_002690	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO493_002695	COG2111	Na H antiporter
IXO493_002695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO493_002745	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO493_002755	COG0456	acetyltransferase
IXO493_002775	COG2801	Transposase and inactivated derivatives
IXO493_002785	COG4221	oxidoreductase activity
IXO493_002830	COG3039	Transposase
IXO493_002850	COG0697	spore germination
IXO493_002855	COG4305	rare lipoprotein A
IXO493_002860	COG5297	Belongs to the glycosyl hydrolase family 6
IXO493_002870	COG1113	amino acid transport
IXO493_002880	COG0598	Magnesium transport protein CorA
IXO493_002950	COG5297	Belongs to the glycosyl hydrolase family 6
IXO493_002950	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO493_002955	COG0659	secondary active sulfate transmembrane transporter activity
IXO493_002990	COG3275	phosphorelay sensor kinase activity
IXO493_003000	COG0181	hydroxymethylbilane synthase activity
IXO493_003025	COG1505	serine-type exopeptidase activity
IXO493_003040	COG3039	Transposase
IXO493_003045	COG0436	Aminotransferase
IXO493_003075	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO493_003105	COG0308	aminopeptidase N
IXO493_003110	COG2199	diguanylate cyclase activity
IXO493_003160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO493_003165	COG1077	Cell shape determining protein MreB Mrl
IXO493_003170	COG1792	Involved in formation and maintenance of cell shape
IXO493_003185	COG0772	Belongs to the SEDS family
IXO493_003220	COG2951	lytic endotransglycosylase activity
IXO493_003225	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO493_003230	COG1686	Belongs to the peptidase S11 family
IXO493_003245	COG2921	Belongs to the UPF0250 family
IXO493_003270	COG1056	cytidyltransferase-related domain
IXO493_003270	COG1051	belongs to the nudix hydrolase family
IXO493_003305	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO493_003310	COG0673	inositol 2-dehydrogenase activity
IXO493_003315	COG2823	Periplasmic or secreted lipoprotein
IXO493_003320	COG4251	negative regulation of phosphorylation
IXO493_003325	COG0784	Response regulator, receiver
IXO493_003330	COG4191	Histidine kinase
IXO493_003335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO493_003385	COG3250	beta-galactosidase activity
IXO493_003400	COG2188	Transcriptional regulator
IXO493_003410	COG1609	Transcriptional regulator
IXO493_003415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO493_003420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO493_003430	COG1215	transferase activity, transferring glycosyl groups
IXO493_003435	COG0726	polysaccharide deacetylase
IXO493_003435	COG1649	PFAM Uncharacterised BCR, COG1649
IXO493_003515	COG3039	Transposase
IXO493_003520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO493_003525	COG3039	Transposase
IXO493_003560	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO493_003575	COG2205	protein histidine kinase activity
IXO493_003610	COG2205	protein histidine kinase activity
IXO493_003650	COG3039	Transposase
IXO493_003665	COG0488	(ABC) transporter
IXO493_003685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO493_003705	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO493_003705	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO493_003725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO493_003730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO493_003735	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO493_003755	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO493_003760	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO493_003770	COG2205	protein histidine kinase activity
IXO493_003775	COG0745	RESPONSE REGULATOR receiver
IXO493_003780	COG0277	FAD linked oxidase domain protein
IXO493_003785	COG1988	membrane-bound metal-dependent
IXO493_003790	COG0792	nuclease activity
IXO493_003825	COG0275	rRNA processing
IXO493_003830	COG3116	cell division
IXO493_003845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO493_003850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO493_003865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO493_003870	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO493_003875	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO493_003890	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO493_003900	COG1388	LysM domain
IXO493_003900	COG4942	peptidase
IXO493_003905	COG0653	protein targeting
IXO493_003915	COG0494	nUDIX hydrolase
IXO493_003930	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO493_003940	COG1028	Short-chain dehydrogenase reductase Sdr
IXO493_003940	COG0604	alcohol dehydrogenase
IXO493_003940	COG3321	synthase
IXO493_003990	COG2226	methyltransferase
IXO493_003995	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO493_004030	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO493_004035	COG3039	Transposase
IXO493_004050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO493_004060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO493_004065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO493_004075	COG3039	Transposase
IXO493_004095	COG0667	Aldo Keto reductase
IXO493_004150	COG2175	clavaminate synthase activity
IXO493_004160	COG4181	ATPase activity
IXO493_004175	COG0642	Histidine kinase
IXO493_004200	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO493_004220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO493_004245	COG2967	ApaG domain
IXO493_004250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO493_004260	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO493_004275	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO493_004280	COG2096	Adenosyltransferase
IXO493_004290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO493_004295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO493_004335	COG0583	DNA-binding transcription factor activity
IXO493_004340	COG0318	PFAM AMP-dependent synthetase and ligase
IXO493_004350	COG1024	Enoyl-CoA hydratase
IXO493_004370	COG3386	PFAM SMP-30 Gluconolaconase
IXO493_004485	COG1902	pentaerythritol trinitrate reductase activity
IXO493_004485	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO493_004490	COG0604	alcohol dehydrogenase
IXO493_004515	COG0156	8-amino-7-oxononanoate synthase activity
IXO493_004520	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO493_004525	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO493_004530	COG4208	sulfate ABC transporter
IXO493_004535	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO493_004565	COG0588	phosphoglycerate mutase activity
IXO493_004575	COG0285	dihydrofolate synthase activity
IXO493_004595	COG2833	Protein of unknown function (DUF455)
IXO493_004615	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO493_004620	COG0671	phosphoesterase, PA-phosphatase related
IXO493_004625	COG0438	transferase activity, transferring glycosyl groups
IXO493_004635	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO493_004650	COG4783	chaperone-mediated protein folding
IXO493_004675	COG0473	3-isopropylmalate dehydrogenase activity
IXO493_004725	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO493_004765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO493_004805	COG0631	protein serine/threonine phosphatase activity
IXO493_004875	COG0582	viral genome integration into host DNA
IXO493_004885	COG0859	PFAM glycosyl transferase family 9
IXO493_004890	COG3642	lipopolysaccharide core region biosynthetic process
IXO493_004895	COG1234	tRNA 3'-trailer cleavage
IXO493_004900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO493_004910	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO493_004915	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO493_004920	COG0314	molybdopterin synthase activity
IXO493_004950	COG0537	adenosine 5'-monophosphoramidase activity
IXO493_004970	COG0714	Associated with various cellular activities
IXO493_004990	COG0242	peptide deformylase activity
IXO493_005070	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO493_005075	COG0726	polysaccharide deacetylase
IXO493_005100	COG1162	GTPase activity
IXO493_005125	COG2211	Major facilitator Superfamily
IXO493_005135	COG1609	Transcriptional regulator
IXO493_005140	COG1028	Short-chain dehydrogenase reductase Sdr
IXO493_005145	COG2851	Citrate transporter
IXO493_005160	COG0642	Histidine kinase
IXO493_005170	COG2197	response regulator
IXO493_005185	COG0583	DNA-binding transcription factor activity
IXO493_005200	COG4191	Histidine kinase
IXO493_005220	COG0280	phosphate acetyltransferase
IXO493_005220	COG0281	malic enzyme
IXO493_005285	COG0352	thiamine-phosphate diphosphorylase activity
IXO493_005290	COG1773	rubredoxin
IXO493_005295	COG2912	Transglutaminase-like superfamily
IXO493_005305	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO493_005315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO493_005340	COG0006	proline dipeptidase activity
IXO493_005375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO493_005390	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO493_005395	COG1561	YicC-like family, N-terminal region
IXO493_005420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO493_005430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO493_005455	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO493_005500	COG0714	Associated with various cellular activities
IXO493_005520	COG2304	oxidoreductase activity
IXO493_005540	COG1301	dicarboxylic acid transport
IXO493_005545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO493_005555	COG0739	heme binding
IXO493_005560	COG1376	ErfK ybiS ycfS ynhG family protein
IXO493_005585	COG1022	Amp-dependent synthetase and ligase
IXO493_005595	COG1028	Short-chain dehydrogenase reductase Sdr
IXO493_005610	COG0642	Histidine kinase
IXO493_005630	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO493_005635	COG4149	molybdate abc transporter
IXO493_005640	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO493_005645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO493_005645	COG3453	Protein conserved in bacteria
IXO493_005685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO493_005705	COG2205	protein histidine kinase activity
IXO493_005710	COG0745	RESPONSE REGULATOR receiver
IXO493_005765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO493_005770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO493_005820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO493_005835	COG2801	Transposase and inactivated derivatives
IXO493_005905	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO493_005915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXO493_005920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO493_005935	COG1842	Phage shock protein A
IXO493_005960	COG0754	glutathionylspermidine amidase activity
IXO493_006015	COG0531	amino acid
IXO493_006020	COG2197	response regulator
IXO493_006035	COG1113	amino acid transport
IXO493_006050	COG1271	oxidase subunit
IXO493_006055	COG1294	oxidase, subunit
IXO493_006065	COG2239	Acts as a magnesium transporter
IXO493_006070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO493_006075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO493_006090	COG1660	Displays ATPase and GTPase activities
IXO493_006095	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO493_006100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO493_006115	COG1137	ATPase activity
IXO493_006120	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO493_006130	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO493_006140	COG0271	Belongs to the BolA IbaG family
IXO493_006145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO493_006165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO493_006180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO493_006190	COG0628	permease
IXO493_006200	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO493_006205	COG3178	'Phosphotransferase
IXO493_006220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO493_006225	COG1555	photosystem II stabilization
IXO493_006275	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO493_006285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO493_006305	COG0228	four-way junction DNA binding
IXO493_006310	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO493_006315	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO493_006330	COG0534	Mate efflux family protein
IXO493_006365	COG0542	response to heat
IXO493_006400	COG4206	TonB-dependent receptor
IXO493_006460	COG0019	diaminopimelate decarboxylase activity
IXO493_006470	COG2814	Major facilitator Superfamily
IXO493_006475	COG4264	IucA IucC family
IXO493_006485	COG4772	TonB-dependent receptor
IXO493_006500	COG4651	solute:proton antiporter activity
IXO493_006500	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO493_006540	COG0488	(ABC) transporter
IXO493_006565	COG0657	acetylesterase activity
IXO493_006565	COG2755	lipolytic protein G-D-S-L family
IXO493_006610	COG2207	Transcriptional regulator
IXO493_006615	COG0326	Molecular chaperone. Has ATPase activity
IXO493_006640	COG3328	transposase activity
IXO493_006645	COG0174	glutamine synthetase
IXO493_006650	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO493_006660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO493_006675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO493_006700	COG2146	nitrite reductase [NAD(P)H] activity
IXO493_006710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO493_006715	COG0719	Fe-S assembly protein
IXO493_006720	COG0396	ATPase activity
IXO493_006725	COG0719	Fe-S assembly protein
IXO493_006730	COG1959	2 iron, 2 sulfur cluster binding
IXO493_006750	COG0693	protein deglycase activity
IXO493_006790	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO493_006820	COG0519	Catalyzes the synthesis of GMP from XMP
IXO493_006830	COG1678	Uncharacterized ACR, COG1678
IXO493_006835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO493_006865	COG1764	response to oxidative stress
IXO493_006875	COG0384	phenazine biosynthesis protein PhzF
IXO493_006885	COG0527	aspartate kinase activity
IXO493_006910	COG0142	geranyltranstransferase activity
IXO493_006915	COG0629	single-stranded DNA binding
IXO493_006920	COG2203	Gaf domain
IXO493_006920	COG3706	GGDEF domain
IXO493_006920	COG4251	negative regulation of phosphorylation
IXO493_006920	COG5001	Diguanylate cyclase
IXO493_006950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO493_006995	COG2879	small protein
IXO493_007000	COG1966	Carbon starvation protein
IXO493_007005	COG1741	Belongs to the pirin family
IXO493_007055	COG3328	transposase activity
IXO493_007070	COG3179	chitinase
IXO493_007095	COG3039	Transposase
IXO493_007120	COG3179	chitinase
IXO493_007255	COG3039	Transposase
IXO493_007260	COG3039	Transposase
IXO493_007340	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO493_007345	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO493_007350	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO493_007355	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO493_007390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO493_007395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO493_007435	COG0587	DNA-directed DNA polymerase activity
IXO493_007450	COG1297	OPT oligopeptide transporter protein
IXO493_007470	COG0823	Involved in the tonB-independent uptake of proteins
IXO493_007470	COG1506	peptidase
IXO493_007490	COG1917	Cupin 2, conserved barrel domain protein
IXO493_007490	COG2207	Transcriptional regulator
IXO493_007515	COG0753	catalase activity
IXO493_007555	COG0469	pyruvate kinase activity
IXO493_007560	COG3588	fructose-bisphosphate aldolase
IXO493_007565	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO493_007615	COG2198	Histidine kinase
IXO493_007615	COG2205	protein histidine kinase activity
IXO493_007615	COG0784	Response regulator, receiver
IXO493_007635	COG0175	sulfate reduction
IXO493_007640	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO493_007645	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO493_007650	COG0175	sulfate reduction
IXO493_007655	COG0529	Catalyzes the synthesis of activated sulfate
IXO493_007655	COG2895	sulfate adenylyltransferase (ATP) activity
IXO493_007665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO493_007670	COG0308	aminopeptidase N
IXO493_007690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO493_007710	COG1970	mechanosensitive ion channel activity
IXO493_007740	COG3273	potassium ion transport
IXO493_007740	COG0471	metal ion transport
IXO493_007750	COG2022	thiamine diphosphate biosynthetic process
IXO493_007845	COG3039	Transposase
IXO493_007885	COG3039	Transposase
IXO493_007920	COG3118	belongs to the thioredoxin family
IXO493_007945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO493_007970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO493_008000	COG2968	Membrane
IXO493_008015	COG3164	Protein of unknown function
IXO493_008025	COG0312	modulator of DNA gyrase
IXO493_008030	COG3028	Belongs to the UPF0307 family
IXO493_008035	COG0312	modulator of DNA gyrase
IXO493_008060	COG0142	geranyltranstransferase activity
IXO493_008065	COG1722	exodeoxyribonuclease VII activity
IXO493_008070	COG0037	tRNA processing
IXO493_008075	COG1785	Belongs to the alkaline phosphatase family
IXO493_008080	COG1301	dicarboxylic acid transport
IXO493_008095	COG0791	NLP P60 protein
IXO493_008100	COG0791	NLP P60 protein
IXO493_008105	COG1047	Peptidyl-prolyl cis-trans
IXO493_008110	COG2311	Membrane
IXO493_008115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO493_008155	COG0489	protein tyrosine kinase activity
IXO493_008160	COG0717	Belongs to the dCTP deaminase family
IXO493_008180	COG0412	Dienelactone hydrolase
IXO493_008190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO493_008230	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO493_008235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO493_008240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO493_008245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO493_008265	COG0101	tRNA pseudouridine synthase activity
IXO493_008270	COG0135	phosphoribosylanthranilate isomerase activity
IXO493_008290	COG0159	tryptophan synthase activity
IXO493_008295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO493_008300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO493_008350	COG0149	triose-phosphate isomerase activity
IXO493_008365	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO493_008375	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO493_008380	COG0649	NAD binding
IXO493_008385	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO493_008390	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO493_008395	COG1034	ATP synthesis coupled electron transport
IXO493_008400	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO493_008430	COG1007	ATP synthesis coupled electron transport
IXO493_008440	COG0779	Required for maturation of 30S ribosomal subunits
IXO493_008445	COG0195	Participates in both transcription termination and antitermination
IXO493_008465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO493_008470	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO493_008505	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO493_008515	COG2095	MarC family integral membrane protein
IXO493_008530	COG1611	Belongs to the LOG family
IXO493_008645	COG1192	Involved in chromosome partitioning
IXO493_008740	COG3179	chitinase
IXO493_008785	COG4695	Portal protein
IXO493_008850	COG4969	Belongs to the N-Me-Phe pilin family
IXO493_008855	COG0556	nucleotide-excision repair
IXO493_008895	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO493_008910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO493_008965	COG0438	transferase activity, transferring glycosyl groups
IXO493_008970	COG0438	transferase activity, transferring glycosyl groups
IXO493_008980	COG0438	transferase activity, transferring glycosyl groups
IXO493_009020	COG3040	lipid binding
IXO493_009050	COG3039	Transposase
IXO493_009115	COG0784	Response regulator, receiver
IXO493_009115	COG4191	Histidine kinase
IXO493_009135	COG0552	protein localization to endoplasmic reticulum
IXO493_009145	COG3938	Belongs to the proline racemase family
IXO493_009150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO493_009165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO493_009175	COG0006	proline dipeptidase activity
IXO493_009190	COG0531	amino acid
IXO493_009240	COG4206	TonB-dependent receptor
IXO493_009325	COG0746	molybdenum cofactor guanylyltransferase activity
IXO493_009350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO493_009350	COG1648	precorrin-2 dehydrogenase activity
IXO493_009395	COG3039	Transposase
IXO493_009405	COG3039	Transposase
IXO493_009445	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO493_009465	COG1054	Belongs to the UPF0176 family
IXO493_009480	COG1530	ribonuclease E activity
IXO493_009490	COG3064	Membrane
IXO493_009495	COG0428	transporter
IXO493_009500	COG0428	transporter
IXO493_009510	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO493_009575	COG3039	Transposase
IXO493_009695	COG0631	protein serine/threonine phosphatase activity
IXO493_009700	COG0515	serine threonine protein kinase
IXO493_009730	COG1858	cytochrome C peroxidase
IXO493_009785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO493_009805	COG2201	protein-glutamate methylesterase activity
IXO493_009835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO493_009855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO493_009870	COG1595	DNA-templated transcription, initiation
IXO493_009920	COG2244	polysaccharide biosynthetic process
IXO493_009950	COG2264	protein methyltransferase activity
IXO493_009960	COG0438	transferase activity, transferring glycosyl groups
IXO493_009975	COG1136	(ABC) transporter
IXO493_009980	COG1132	(ABC) transporter
IXO493_009990	COG0477	Major facilitator Superfamily
IXO493_010000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO493_010015	COG1253	flavin adenine dinucleotide binding
IXO493_010025	COG0306	phosphate transporter
IXO493_010055	COG0504	CTP synthase activity
IXO493_010060	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO493_010070	COG0148	phosphopyruvate hydratase activity
IXO493_010075	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO493_010080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO493_010090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO493_010100	COG2840	Smr protein MutS2
IXO493_010105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO493_010110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO493_010115	COG1238	metal cluster binding
IXO493_010130	COG1534	Rna-binding protein
IXO493_010135	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO493_010145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO493_010150	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO493_010160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO493_010165	COG1546	Belongs to the CinA family
IXO493_010180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO493_010185	COG2137	regulation of response to DNA damage stimulus
IXO493_010190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO493_010195	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO493_010220	COG0305	Participates in initiation and elongation during chromosome replication
IXO493_010225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO493_010245	COG1741	Belongs to the pirin family
IXO493_010250	COG0583	DNA-binding transcription factor activity
IXO493_010280	COG0351	phosphomethylpyrimidine kinase
IXO493_010290	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO493_010295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO493_010310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO493_010320	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO493_010325	COG3734	2-keto-3-deoxy-galactonokinase
IXO493_010335	COG4948	Mandelate Racemase Muconate Lactonizing
IXO493_010340	COG0800	Aldolase
IXO493_010355	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO493_010365	COG1070	Carbohydrate kinase
IXO493_010375	COG0477	Major facilitator Superfamily
IXO493_010395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO493_010445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO493_010450	COG2258	MOSC domain
IXO493_010460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO493_010465	COG0505	Belongs to the CarA family
IXO493_010475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO493_010480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO493_010490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO493_010545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IXO493_010555	COG2198	Histidine kinase
IXO493_010555	COG0784	Response regulator, receiver
IXO493_010555	COG2205	protein histidine kinase activity
IXO493_010560	COG1024	Enoyl-CoA hydratase
IXO493_010565	COG0318	PFAM AMP-dependent synthetase and ligase
IXO493_010595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO493_010650	COG3039	Transposase
IXO493_010670	COG0835	chemotaxis
IXO493_010685	COG0840	transmembrane signaling receptor activity
IXO493_010690	COG0840	transmembrane signaling receptor activity
IXO493_010695	COG0840	transmembrane signaling receptor activity
IXO493_010700	COG0840	transmembrane signaling receptor activity
IXO493_010710	COG0840	transmembrane signaling receptor activity
IXO493_010720	COG0840	transmembrane signaling receptor activity
IXO493_010730	COG0840	transmembrane signaling receptor activity
IXO493_010750	COG0745	RESPONSE REGULATOR receiver
IXO493_010760	COG0835	chemotaxis
IXO493_010770	COG1360	Flagellar Motor Protein
IXO493_010775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO493_010795	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO493_010805	COG4771	TonB-dependent receptor
IXO493_010920	COG3039	Transposase
IXO493_010945	COG3039	Transposase
IXO493_010960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO493_010960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO493_010965	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO493_010970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO493_010970	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO493_010975	COG1609	Transcriptional regulator
IXO493_011000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO493_011005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO493_011015	COG2902	Dehydrogenase
IXO493_011020	COG3039	Transposase
IXO493_011030	COG0784	Response regulator, receiver
IXO493_011030	COG2205	protein histidine kinase activity
IXO493_011030	COG5002	protein histidine kinase activity
IXO493_011035	COG2733	membrane
IXO493_011045	COG1121	(ABC) transporter
IXO493_011050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO493_011055	COG2223	nitrite transmembrane transporter activity
IXO493_011065	COG0243	molybdopterin cofactor binding
IXO493_011075	COG0477	Major facilitator Superfamily
IXO493_011085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO493_011090	COG0174	glutamine synthetase
IXO493_011170	COG3039	Transposase
IXO493_011180	COG0583	DNA-binding transcription factor activity
IXO493_011255	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO493_011260	COG0235	Class ii aldolase
IXO493_011265	COG0531	amino acid
IXO493_011270	COG0531	amino acid
IXO493_011280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO493_011285	COG0277	FAD linked oxidase domain protein
IXO493_011350	COG0436	Aminotransferase
IXO493_011375	COG1187	pseudouridine synthase activity
IXO493_011380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO493_011385	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO493_011390	COG2350	Protein conserved in bacteria
IXO493_011420	COG1175	transmembrane transport
IXO493_011425	COG0395	ABC-type sugar transport system, permease component
IXO493_011450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO493_011460	COG2957	Belongs to the agmatine deiminase family
IXO493_011475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO493_011480	COG0539	negative regulation of cytoplasmic translation
IXO493_011485	COG0776	regulation of translation
IXO493_011495	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO493_011500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO493_011510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO493_011530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO493_011545	COG0582	viral genome integration into host DNA
IXO493_011640	COG3002	Belongs to the UPF0753 family
IXO493_011645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO493_011650	COG0583	DNA-binding transcription factor activity
IXO493_011680	COG0583	DNA-binding transcription factor activity
IXO493_011685	COG0583	DNA-binding transcription factor activity
IXO493_011700	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO493_011720	COG0668	transmembrane transport
IXO493_011730	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IXO493_011745	COG1028	Short-chain dehydrogenase reductase Sdr
IXO493_011750	COG1183	phosphatidylcholine synthase activity
IXO493_011760	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO493_011775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO493_011775	COG0723	plastoquinol--plastocyanin reductase activity
IXO493_011785	COG2183	response to ionizing radiation
IXO493_011800	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO493_011815	COG0671	phosphoesterase, PA-phosphatase related
IXO493_011835	COG1794	racemase activity, acting on amino acids and derivatives
IXO493_011840	COG0697	spore germination
IXO493_011845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IXO493_011850	COG0167	dihydroorotate dehydrogenase activity
IXO493_011865	COG1012	belongs to the aldehyde dehydrogenase family
IXO493_011900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO493_011915	COG0124	histidyl-tRNA synthetase
IXO493_011935	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO493_011950	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO493_011950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO493_011960	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO493_011970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO493_011970	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO493_012010	COG0653	protein targeting
IXO493_012035	COG3039	Transposase
IXO493_012095	COG2201	protein-glutamate methylesterase activity
IXO493_012105	COG2801	Transposase and inactivated derivatives
IXO493_012120	COG3039	Transposase
IXO493_012140	COG3328	transposase activity
IXO493_012175	COG0322	excinuclease ABC activity
IXO493_012185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO493_012195	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO493_012210	COG0811	peptide transport
IXO493_012235	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO493_012250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO493_012265	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO493_012280	COG0354	folic acid binding
IXO493_012295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO493_012305	COG0363	glucosamine-6-phosphate deaminase activity
IXO493_012310	COG0129	dihydroxy-acid dehydratase activity
IXO493_012315	COG0800	Aldolase
IXO493_012355	COG5002	protein histidine kinase activity
IXO493_012355	COG0784	Response regulator, receiver
IXO493_012355	COG2205	protein histidine kinase activity
IXO493_012370	COG3039	Transposase
IXO493_012440	COG0386	Belongs to the glutathione peroxidase family
IXO493_012525	COG4251	negative regulation of phosphorylation
IXO493_012525	COG3706	GGDEF domain
IXO493_012525	COG2203	Gaf domain
IXO493_012525	COG5001	Diguanylate cyclase
IXO493_012540	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO493_012570	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO493_012575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO493_012585	COG0617	tRNA 3'-terminal CCA addition
IXO493_012595	COG1469	GTP cyclohydrolase I activity
IXO493_012600	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO493_012645	COG4566	intracellular signal transduction
IXO493_012655	COG3039	Transposase
IXO493_012680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO493_012685	COG1605	Chorismate mutase
IXO493_012685	COG0077	Prephenate dehydratase
IXO493_012695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO493_012735	COG1228	amidohydrolase
IXO493_012740	COG2986	histidine ammonia-lyase
IXO493_012750	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO493_012775	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO493_012790	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO493_012810	COG3115	cell septum assembly
IXO493_012820	COG0359	binds to the 23S rRNA
IXO493_012830	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO493_012835	COG0316	Belongs to the HesB IscA family
IXO493_012865	COG0288	reversible hydration of carbon dioxide
IXO493_012900	COG2925	Exonuclease
IXO493_012910	COG0667	Aldo Keto reductase
IXO493_012935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO493_012935	COG0116	Belongs to the methyltransferase superfamily
IXO493_012980	COG0494	nUDIX hydrolase
IXO493_012990	COG1024	Enoyl-CoA hydratase
IXO493_013000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO493_013020	COG3039	Transposase
IXO493_013060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO493_013065	COG0573	inorganic phosphate transmembrane transporter activity
IXO493_013080	COG0704	Plays a role in the regulation of phosphate uptake
IXO493_013090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO493_013125	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO493_013130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO493_013135	COG1862	Preprotein translocase
IXO493_013140	COG0343	queuine tRNA-ribosyltransferase activity
IXO493_013190	COG3039	Transposase
IXO493_013225	COG3039	Transposase
IXO493_013250	COG0405	Gamma-glutamyltransferase
IXO493_013255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO493_013265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO493_013270	COG0742	ribosomal rna small subunit methyltransferase
IXO493_013310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO493_013365	COG0303	'Molybdopterin
IXO493_013375	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO493_013385	COG1426	Protein conserved in bacteria
IXO493_013395	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO493_013410	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO493_013410	COG1024	Enoyl-CoA hydratase
IXO493_013415	COG0183	Belongs to the thiolase family
IXO493_013420	COG0038	chloride channel
IXO493_013440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO493_013460	COG1674	ftsk spoiiie
IXO493_013465	COG0492	ferredoxin-NADP+ reductase activity
IXO493_013490	COG0542	response to heat
IXO493_013505	COG0482	sulfurtransferase activity
IXO493_013530	COG5001	Diguanylate cyclase
IXO493_013535	COG4585	Histidine kinase
IXO493_013545	COG5002	protein histidine kinase activity
IXO493_013565	COG0835	chemotaxis
IXO493_013565	COG0784	Response regulator, receiver
IXO493_013575	COG1558	bacterial-type flagellum-dependent cell motility
IXO493_013580	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO493_013590	COG4787	bacterial-type flagellum-dependent cell motility
IXO493_013625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO493_013630	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO493_013660	COG2201	protein-glutamate methylesterase activity
IXO493_013680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO493_013690	COG1028	Short-chain dehydrogenase reductase Sdr
IXO493_013720	COG1677	Flagellar hook-basal body complex protein FliE
IXO493_013770	COG3190	flagellar
IXO493_013785	COG1684	flagellar biosynthetic protein fliR
IXO493_013840	COG0784	Response regulator, receiver
IXO493_013840	COG0643	Histidine kinase
IXO493_013840	COG2198	Histidine kinase
IXO493_013865	COG3039	Transposase
IXO493_013900	COG3209	COG3209 Rhs family protein
IXO493_013915	COG3039	Transposase
IXO493_013995	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO493_014000	COG4988	ABC transporter
IXO493_014010	COG1271	oxidase subunit
IXO493_014040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO493_014060	COG0165	Argininosuccinate lyase
IXO493_014075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO493_014080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO493_014090	COG0137	argininosuccinate synthase activity
IXO493_014095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO493_014110	COG2166	iron-sulfur cluster assembly
IXO493_014135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO493_014170	COG3039	Transposase
IXO493_014180	COG4677	pectinesterase activity
IXO493_014205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO493_014210	COG0402	S-adenosylhomocysteine deaminase activity
IXO493_014225	COG1509	lysine 2,3-aminomutase activity
IXO493_014230	COG5001	Diguanylate cyclase
IXO493_014230	COG3300	MHYT domain
IXO493_014245	COG0483	inositol monophosphate 1-phosphatase activity
IXO493_014250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO493_014270	COG0488	(ABC) transporter
IXO493_014275	COG0513	Belongs to the DEAD box helicase family
IXO493_014280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO493_014285	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IXO493_014295	COG0625	glutathione transferase activity
IXO493_014305	COG1671	Belongs to the UPF0178 family
IXO493_014310	COG4681	YaeQ
IXO493_014315	COG2081	HI0933 family
IXO493_014325	COG0501	Belongs to the peptidase M48B family
IXO493_014335	COG1028	Short-chain dehydrogenase reductase Sdr
IXO493_014355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO493_014360	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO493_014365	COG0802	atpase or kinase
IXO493_014370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO493_014370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO493_014375	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO493_014395	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO493_014480	COG3328	transposase activity
IXO493_014515	COG2969	positive regulation of protein catabolic process
IXO493_014520	COG0625	glutathione transferase activity
IXO493_014525	COG2857	Cytochrome c1
IXO493_014530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO493_014535	COG0723	plastoquinol--plastocyanin reductase activity
IXO493_014540	COG0741	lytic transglycosylase activity
IXO493_014565	COG1702	phosphate starvation-inducible protein PhoH
IXO493_014585	COG4535	Mg2 and Co2 transporter CorC
IXO493_014600	COG1012	belongs to the aldehyde dehydrogenase family
IXO493_014610	COG1177	transmembrane transport
IXO493_014620	COG3842	ATPase activity
IXO493_014690	COG3039	Transposase
IXO493_014700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO493_014720	COG0557	exoribonuclease II activity
IXO493_014745	COG1960	acyl-CoA dehydrogenase activity
IXO493_014750	COG2226	methyltransferase
IXO493_014755	COG1410	methionine synthase
IXO493_014755	COG0646	methionine synthase
IXO493_014760	COG1410	methionine synthase
IXO493_014760	COG0646	methionine synthase
IXO493_014770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO493_014780	COG1609	Transcriptional regulator
IXO493_014795	COG2900	Belongs to the SlyX family
IXO493_014810	COG0386	Belongs to the glutathione peroxidase family
IXO493_014820	COG1725	Transcriptional regulator
IXO493_014825	COG1131	(ABC) transporter
IXO493_014905	COG2850	peptidyl-arginine hydroxylation
IXO493_014940	COG1132	(ABC) transporter
IXO493_014955	COG0583	DNA-binding transcription factor activity
IXO493_014970	COG0287	Prephenate dehydrogenase
IXO493_014970	COG1605	Chorismate mutase
IXO493_014975	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO493_014980	COG0484	heat shock protein binding
IXO493_014990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO493_015000	COG0497	DNA recombination
IXO493_015010	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO493_015015	COG2914	Belongs to the UPF0125 (RnfH) family
IXO493_015025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO493_015040	COG1960	acyl-CoA dehydrogenase activity
IXO493_015050	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO493_015105	COG2814	Major facilitator Superfamily
IXO493_015110	COG1566	PFAM secretion protein HlyD family protein
IXO493_015160	COG4774	siderophore transport
IXO493_015170	COG0367	asparagine synthase
IXO493_015175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO493_015185	COG1393	Belongs to the ArsC family
IXO493_015245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO493_015260	COG0233	cytoplasmic translational termination
IXO493_015270	COG0575	Belongs to the CDS family
IXO493_015280	COG0750	zinc metalloprotease
IXO493_015295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO493_015300	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO493_015320	COG0825	malonyl-CoA metabolic process
IXO493_015330	COG4771	TonB-dependent receptor
IXO493_015360	COG1981	membrane
IXO493_015405	COG2895	sulfate adenylyltransferase (ATP) activity
IXO493_015405	COG0529	Catalyzes the synthesis of activated sulfate
IXO493_015445	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO493_015460	COG2040	homocysteine
IXO493_015465	COG0833	amino acid
IXO493_015485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO493_015485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO493_015495	COG2878	Part of a membrane complex involved in electron transport
IXO493_015510	COG1595	DNA-templated transcription, initiation
IXO493_015535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO493_015550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO493_015555	COG0251	oxidation-reduction process
IXO493_015565	COG0392	lysyltransferase activity
IXO493_015565	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO493_015595	COG3039	Transposase
IXO493_015620	COG2814	Major facilitator Superfamily
IXO493_015625	COG1902	pentaerythritol trinitrate reductase activity
IXO493_015635	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO493_015650	COG1047	Peptidyl-prolyl cis-trans
IXO493_015685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO493_015700	COG1451	nucleotide metabolic process
IXO493_015705	COG3039	Transposase
IXO493_015725	COG0183	Belongs to the thiolase family
IXO493_015755	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO493_015755	COG1793	dna ligase
IXO493_015765	COG1793	dna ligase
IXO493_015770	COG1201	RNA secondary structure unwinding
IXO493_015790	COG1278	Cold shock
IXO493_015795	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO493_015800	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO493_015810	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO493_015815	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IXO493_015820	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO493_015825	COG3039	Transposase
IXO493_015835	COG2954	triphosphatase activity
IXO493_015850	COG1381	Involved in DNA repair and RecF pathway recombination
IXO493_015875	COG0481	GTPase activity
IXO493_015880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO493_015895	COG1024	Enoyl-CoA hydratase
IXO493_015895	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO493_015920	COG1024	Enoyl-CoA hydratase
IXO493_015925	COG1960	acyl-CoA dehydrogenase activity
IXO493_015950	COG3250	beta-galactosidase activity
IXO493_015995	COG2353	YceI-like domain
IXO493_016005	COG2353	YceI-like domain
IXO493_016020	COG1760	l-serine dehydratase
IXO493_016030	COG0626	cystathionine gamma-synthase activity
IXO493_016035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO493_016040	COG0739	heme binding
IXO493_016050	COG1272	protein, Hemolysin III
IXO493_016070	COG0463	Glycosyl transferase, family 2
IXO493_016080	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO493_016090	COG4771	TonB-dependent receptor
IXO493_016095	COG1309	transcriptional regulator
IXO493_016105	COG1960	acyl-CoA dehydrogenase activity
IXO493_016125	COG3039	Transposase
IXO493_016140	COG0509	glycine decarboxylation via glycine cleavage system
IXO493_016155	COG0330	HflC and HflK could
IXO493_016170	COG3956	TIGRFAM MazG family protein
IXO493_016180	COG0494	nUDIX hydrolase
IXO493_016190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO493_016195	COG0837	glucose binding
IXO493_016210	COG1388	LysM domain
IXO493_016210	COG3858	chitin binding
IXO493_016220	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO493_016230	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO493_016270	COG3537	Alpha-1,2-mannosidase
IXO493_016315	COG1446	asparaginase
IXO493_016340	COG3039	Transposase
IXO493_016360	COG0643	Histidine kinase
IXO493_016360	COG0784	Response regulator, receiver
IXO493_016360	COG2198	Histidine kinase
IXO493_016365	COG0840	transmembrane signaling receptor activity
IXO493_016370	COG0835	chemotaxis
IXO493_016385	COG0189	ligase activity
IXO493_016395	COG1397	ADP-ribosylglycohydrolase
IXO493_016405	COG1199	ATP-dependent helicase activity
IXO493_016415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO493_016420	COG1215	transferase activity, transferring glycosyl groups
IXO493_016430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO493_016450	COG0535	radical SAM domain protein
IXO493_016455	COG0535	radical SAM domain protein
IXO493_016485	COG1643	Atp-dependent helicase
IXO493_016490	COG0783	Belongs to the Dps family
IXO493_016495	COG0514	ATP-dependent DNA helicase (RecQ)
IXO493_016565	COG4695	Portal protein
IXO493_016610	COG3179	chitinase
IXO493_016790	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO493_016850	COG1187	pseudouridine synthase activity
IXO493_016855	COG0602	queuosine metabolic process
IXO493_016865	COG2885	chlorophyll binding
IXO493_016880	COG0848	biopolymer transport protein
IXO493_016890	COG0824	Thioesterase
IXO493_016895	COG2255	four-way junction helicase activity
IXO493_016905	COG0632	four-way junction helicase activity
IXO493_017015	COG3328	transposase activity
IXO493_017025	COG3209	COG3209 Rhs family protein
IXO493_017045	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO493_017050	COG1845	cytochrome c oxidase, subunit III
IXO493_017055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO493_017070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO493_017075	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO493_017085	COG0196	riboflavin kinase activity
IXO493_017090	COG0728	peptidoglycan biosynthetic process
IXO493_017095	COG0268	Binds directly to 16S ribosomal RNA
IXO493_017100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO493_017105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO493_017115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO493_017120	COG0824	Thioesterase
IXO493_017135	COG1946	Acyl-CoA thioesterase
IXO493_017145	COG1595	DNA-templated transcription, initiation
IXO493_017160	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO493_017195	COG1877	trehalose-phosphatase activity
IXO493_017200	COG3387	PFAM Glycoside hydrolase 15-related
IXO493_017225	COG0564	pseudouridine synthase activity
IXO493_017230	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO493_017235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO493_017235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO493_017245	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO493_017250	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO493_017290	COG2194	sulfuric ester hydrolase activity
IXO493_017295	COG4969	Belongs to the N-Me-Phe pilin family
IXO493_017305	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO493_017335	COG3039	Transposase
IXO493_017365	COG1132	(ABC) transporter
IXO493_017395	COG0745	RESPONSE REGULATOR receiver
IXO493_017400	COG5000	phosphorelay sensor kinase activity
IXO493_017400	COG5002	protein histidine kinase activity
IXO493_017405	COG0475	glutathione-regulated potassium exporter activity
IXO493_017415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO493_017435	COG1187	pseudouridine synthase activity
IXO493_017440	COG5002	protein histidine kinase activity
IXO493_017440	COG5001	Diguanylate cyclase
IXO493_017540	COG1028	Short-chain dehydrogenase reductase Sdr
IXO493_017555	COG0415	Belongs to the DNA photolyase family
IXO493_017560	COG0305	Participates in initiation and elongation during chromosome replication
IXO493_017570	COG0367	asparagine synthase
IXO493_017585	COG1960	acyl-CoA dehydrogenase activity
IXO493_017600	COG0084	hydrolase, TatD family'
IXO493_017605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO493_017665	COG0735	belongs to the Fur family
IXO493_017670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO493_017695	COG3039	Transposase
IXO493_017745	COG2205	protein histidine kinase activity
IXO493_017755	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO493_017765	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO493_017780	COG0643	Histidine kinase
IXO493_017780	COG2198	Histidine kinase
IXO493_017785	COG0840	transmembrane signaling receptor activity
IXO493_017790	COG0835	chemotaxis
IXO493_017795	COG2199	diguanylate cyclase activity
IXO493_017795	COG2200	EAL domain
IXO493_017795	COG2202	Pas domain
IXO493_017800	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO493_017815	COG3590	peptidase
IXO493_017830	COG0588	phosphoglycerate mutase activity
IXO493_017835	COG1515	deoxyribonuclease V activity
IXO493_017845	COG1741	Belongs to the pirin family
IXO493_017930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO493_017940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO493_018035	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO493_018050	COG2197	response regulator
IXO493_018055	COG4585	Histidine kinase
IXO493_018070	COG2894	cell division
IXO493_018075	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO493_018085	COG0642	Histidine kinase
IXO493_018090	COG0745	RESPONSE REGULATOR receiver
IXO493_018095	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO493_018105	COG2194	sulfuric ester hydrolase activity
IXO493_018135	COG3551	Protein conserved in bacteria
IXO493_018195	COG0203	ribosomal protein L17
IXO493_018205	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO493_018210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO493_018220	COG0201	protein transport
IXO493_018230	COG1841	ribosomal large subunit assembly
IXO493_018240	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IXO493_018260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO493_018270	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO493_018275	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO493_018280	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO493_018285	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO493_018295	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO493_018310	COG0089	rRNA binding
IXO493_018315	COG0088	Forms part of the polypeptide exit tunnel
IXO493_018320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO493_018325	COG0051	transcription antitermination factor activity, RNA binding
IXO493_018345	COG0049	tRNA binding
IXO493_018350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO493_018355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO493_018360	COG0085	RNA polymerase activity
IXO493_018365	COG0222	ribosome binding
IXO493_018370	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO493_018380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO493_018385	COG0250	Participates in transcription elongation, termination and antitermination
IXO493_018390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO493_018420	COG0012	GTP binding
IXO493_018425	COG0193	aminoacyl-tRNA hydrolase activity
IXO493_018435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO493_018450	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO493_018460	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO493_018465	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO493_018480	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO493_018500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO493_018505	COG1295	ribonuclease BN
IXO493_018535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO493_018540	COG1404	Belongs to the peptidase S8 family
IXO493_018545	COG1404	Belongs to the peptidase S8 family
IXO493_018555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO493_018580	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO493_018605	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO493_018620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO493_018620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO493_018670	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO493_018680	COG3634	alkyl hydroperoxide reductase activity
IXO493_018685	COG0583	DNA-binding transcription factor activity
IXO493_018695	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO493_018720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO493_018755	COG0584	glycerophosphoryl diester phosphodiesterase
IXO493_018775	COG3039	Transposase
IXO493_018790	COG0625	glutathione transferase activity
IXO493_018795	COG0039	L-malate dehydrogenase activity
IXO493_018800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO493_018805	COG1217	gtp-binding protein TYPA
IXO493_018825	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO493_018960	COG3781	membrane
IXO493_018970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO493_019000	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO493_019020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO493_019045	COG3710	Transcriptional regulator
IXO493_019050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO493_019060	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO493_019090	COG2226	methyltransferase
IXO493_019095	COG0066	3-isopropylmalate dehydratase activity
IXO493_019100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO493_019130	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO493_019135	COG1538	Outer membrane efflux protein
IXO493_019140	COG1519	Transferase
IXO493_019145	COG1560	Kdo2-lipid A biosynthetic process
IXO493_019200	COG0308	aminopeptidase N
IXO493_019205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO493_019215	COG0330	HflC and HflK could
IXO493_019220	COG0330	HflC and HflK could
IXO493_019240	COG0678	peroxiredoxin activity
IXO493_019250	COG2826	transposase and inactivated derivatives, IS30 family
IXO493_019280	COG3039	Transposase
IXO493_019310	COG3829	transcription factor binding
IXO493_019345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO493_019350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO493_019360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO493_019365	COG1028	Short-chain dehydrogenase reductase Sdr
IXO493_019390	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO493_019405	COG3039	Transposase
IXO493_019445	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO493_019495	COG2188	Transcriptional regulator
IXO493_019510	COG1450	Type ii and iii secretion system protein
IXO493_019525	COG3166	PFAM Fimbrial assembly family protein
IXO493_019530	COG3156	type II secretion system protein K
IXO493_019535	COG4795	General secretion pathway protein
IXO493_019540	COG2165	general secretion pathway protein
IXO493_019545	COG4970	Tfp pilus assembly protein FimT
IXO493_019550	COG2165	general secretion pathway protein
IXO493_019555	COG1459	type II secretion system
IXO493_019565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO493_019575	COG1404	Belongs to the peptidase S8 family
IXO493_019585	COG5295	Hep Hag repeat protein
IXO493_019590	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXO493_019590	COG0047	phosphoribosylformylglycinamidine synthase activity
IXO493_019595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO493_019600	COG4974	Belongs to the 'phage' integrase family
IXO493_019610	COG0795	lipopolysaccharide-transporting ATPase activity
IXO493_019620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO493_019635	COG0525	valine-tRNA ligase activity
IXO493_019670	COG3039	Transposase
IXO493_019705	COG3039	Transposase
IXO493_019735	COG1183	phosphatidylcholine synthase activity
IXO493_019745	COG0442	prolyl-tRNA aminoacylation
IXO493_019760	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO493_019765	COG1127	ABC transporter
IXO493_019770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO493_019770	COG3218	ABC-type transport auxiliary lipoprotein component
IXO493_019805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO493_019810	COG0662	Cupin 2, conserved barrel domain protein
IXO493_019810	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO493_019835	COG2086	electron transfer activity
IXO493_019860	COG3328	transposase activity
IXO493_019900	COG0626	cystathionine gamma-synthase activity
IXO493_019930	COG0625	glutathione transferase activity
IXO493_019940	COG0513	Belongs to the DEAD box helicase family
IXO493_019945	COG0720	synthase
IXO493_019955	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO493_019960	COG1956	GAF domain-containing protein
IXO493_019995	COG0339	signal peptide processing
IXO493_020045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO493_020050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO493_020100	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXO493_020105	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO493_020110	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO493_020115	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO493_020125	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO493_020135	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO493_020155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO493_020165	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO493_020195	COG2011	ABC-type metal ion transport system permease component
IXO493_020205	COG0697	spore germination
IXO493_020240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO493_020245	COG1187	pseudouridine synthase activity
IXO493_020250	COG2813	Specifically methylates the guanine in position
IXO493_020280	COG2205	protein histidine kinase activity
IXO493_020280	COG2202	Pas domain
IXO493_020305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO493_020355	COG0745	RESPONSE REGULATOR receiver
IXO493_020370	COG1404	Belongs to the peptidase S8 family
IXO493_020385	COG0842	Transport permease protein
IXO493_020390	COG1131	(ABC) transporter
IXO493_020395	COG0025	NhaP-type Na H and K H
IXO493_020410	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO493_020420	COG1573	uracil-dna glycosylase
IXO493_020430	COG3384	dioxygenase
IXO493_020445	COG0667	Aldo Keto reductase
IXO493_020460	COG3590	peptidase
IXO493_020480	COG0531	amino acid
IXO493_020505	COG2972	Histidine kinase
IXO493_020555	COG1271	oxidase subunit
IXO493_020715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO493_020725	COG1560	Kdo2-lipid A biosynthetic process
IXO493_020775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO493_020775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO493_020780	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO493_020785	COG0242	peptide deformylase activity
IXO493_020790	COG1652	LysM domain
IXO493_020795	COG0758	DNA mediated transformation
IXO493_020800	COG2922	Belongs to the Smg family
IXO493_020815	COG1754	DNA topoisomerase type I activity
IXO493_020815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO493_020820	COG0009	L-threonylcarbamoyladenylate synthase
IXO493_020835	COG1028	Short-chain dehydrogenase reductase Sdr
IXO493_020845	COG0616	signal peptide processing
IXO493_020850	COG0534	Mate efflux family protein
IXO493_020870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO493_020905	COG1324	tolerance protein
IXO493_020915	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO493_020920	COG0511	ligase activity, forming carbon-carbon bonds
IXO493_020930	COG0439	Biotin carboxylase
IXO493_020975	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO493_021035	COG3039	Transposase
IXO493_021060	COG3039	Transposase
IXO493_021130	COG3210	domain, Protein
IXO493_021135	COG2831	hemolysin activation secretion protein
IXO493_021165	COG2267	carboxylic ester hydrolase activity
IXO493_021170	COG2267	carboxylic ester hydrolase activity
IXO493_021180	COG0138	bifunctional purine biosynthesis protein purh
IXO493_021190	COG0151	Belongs to the GarS family
IXO493_021215	COG1289	transmembrane transporter activity
IXO493_021230	COG2814	Major facilitator Superfamily
IXO493_021245	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO493_021280	COG0745	RESPONSE REGULATOR receiver
IXO493_021325	COG0739	heme binding
IXO493_021340	COG2211	Major facilitator Superfamily
IXO493_021345	COG0708	Exodeoxyribonuclease III
IXO493_021360	COG1192	Involved in chromosome partitioning
IXO493_021365	COG1475	DNA binding
IXO493_021380	COG0463	Glycosyl transferase, family 2
IXO493_021405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO493_021415	COG0018	arginyl-trna synthetase
IXO493_021430	COG4221	oxidoreductase activity
IXO493_021455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO493_021460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO493_021475	COG3485	protocatechuate 3,4-dioxygenase
IXO493_021480	COG3485	protocatechuate 3,4-dioxygenase
IXO493_021515	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO493_021520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO493_021530	COG1042	CoA-binding domain protein
IXO493_021530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO493_021530	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO493_021545	COG2239	Acts as a magnesium transporter
IXO493_021560	COG3039	Transposase
IXO493_021570	COG3328	transposase activity
IXO493_021575	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO493_021575	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO493_021585	COG1473	amidohydrolase
IXO493_021590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO493_021595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO493_021605	COG5383	Protein conserved in bacteria
IXO493_021630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO493_021635	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO493_021650	COG0028	Belongs to the TPP enzyme family
IXO493_021655	COG4191	Histidine kinase
IXO493_021680	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO493_021695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO493_021700	COG3177	Filamentation induced by cAMP protein fic
IXO493_021715	COG0596	Alpha beta hydrolase
IXO493_021720	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO493_021725	COG0318	PFAM AMP-dependent synthetase and ligase
IXO493_021730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO493_021780	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO493_021790	COG0129	dihydroxy-acid dehydratase activity
IXO493_021810	COG3039	Transposase
IXO493_021820	COG0408	coproporphyrinogen oxidase activity
IXO493_021860	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXO493_021880	COG2201	protein-glutamate methylesterase activity
IXO493_021925	COG2353	YceI-like domain
IXO493_021955	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO493_021970	COG3386	PFAM SMP-30 Gluconolaconase
IXO493_022015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO493_022035	COG0459	protein refolding
IXO493_022060	COG1252	NADH dehydrogenase
IXO493_022070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO493_022075	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO493_022080	COG2201	protein-glutamate methylesterase activity
IXO493_022085	COG2177	Part of the ABC transporter FtsEX involved in
IXO493_022090	COG2884	Cell division ATP-binding protein ftsE
IXO493_022100	COG3118	belongs to the thioredoxin family
IXO493_022105	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO493_022120	COG0729	surface antigen
IXO493_022125	COG2911	Protein conserved in bacteria
IXO493_022160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO493_022175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO493_022225	COG1733	regulation of RNA biosynthetic process
IXO493_022230	COG0702	epimerase
IXO493_022260	COG0583	DNA-binding transcription factor activity
IXO493_022265	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO493_022285	COG0745	RESPONSE REGULATOR receiver
IXO493_022315	COG1902	pentaerythritol trinitrate reductase activity
IXO493_022320	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO493_022330	COG2814	Major facilitator Superfamily
IXO493_022335	COG0583	DNA-binding transcription factor activity
IXO493_022350	COG0084	hydrolase, TatD family'
IXO493_022395	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO493_022415	COG2072	flavoprotein involved in K transport
IXO493_022475	COG4770	biotin carboxylase activity
IXO493_022480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO493_022485	COG1960	acyl-CoA dehydrogenase activity
IXO493_022540	COG0523	cobalamin synthesis protein
IXO493_022550	COG0697	spore germination
IXO493_022560	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO493_022580	COG4771	TonB-dependent receptor
IXO493_022585	COG0457	Tetratricopeptide repeat
IXO493_022595	COG0752	glycyl-tRNA synthetase alpha subunit
IXO493_022600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO493_022615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO493_022615	COG0519	Catalyzes the synthesis of GMP from XMP
IXO493_022625	COG0805	protein transport
IXO493_022635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO493_022645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO493_022670	COG2974	May be involved in recombination
IXO493_022675	COG0037	tRNA processing
IXO493_022690	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO493_022700	COG4948	Mandelate Racemase Muconate Lactonizing
IXO493_022710	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO493_022715	COG0246	Mannitol dehydrogenase
IXO493_022740	COG3693	PFAM glycoside hydrolase, family 10
IXO493_022760	COG2211	Major facilitator Superfamily
IXO493_022805	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IXO493_022845	COG1846	Transcriptional regulator
IXO493_022850	COG1764	response to oxidative stress
IXO493_022925	COG3549	Plasmid maintenance system killer
IXO493_022935	COG1074	ATP-dependent DNA helicase activity
IXO493_022940	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO493_022985	COG2032	superoxide dismutase activity
IXO493_022990	COG2032	superoxide dismutase activity
IXO493_022995	COG2204	response regulator
IXO493_023000	COG3852	Histidine kinase
IXO493_023005	COG0004	ammonium transporteR
IXO493_023010	COG0347	Belongs to the P(II) protein family
IXO493_023015	COG0174	glutamine synthetase
IXO493_023020	COG1968	undecaprenyl-diphosphatase activity
IXO493_023065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO493_023075	COG2062	phosphohistidine phosphatase, SixA
IXO493_023080	COG0489	protein tyrosine kinase activity
IXO493_023100	COG1396	sequence-specific DNA binding
IXO493_023105	COG3550	peptidyl-serine autophosphorylation
IXO493_023110	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO493_023115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO493_023130	COG0517	IMP dehydrogenase activity
IXO493_023130	COG1125	glycine betaine transport
IXO493_023145	COG1119	ATPase activity
IXO493_023155	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO493_023170	COG3039	Transposase
IXO493_023195	COG0656	L-ascorbic acid biosynthetic process
IXO493_023200	COG2130	NADP-dependent
IXO493_023205	COG0667	Aldo Keto reductase
IXO493_023215	COG1187	pseudouridine synthase activity
IXO493_023225	COG1643	Atp-dependent helicase
IXO493_023230	COG4807	Protein conserved in bacteria
IXO493_023235	COG4948	Mandelate Racemase Muconate Lactonizing
IXO493_023240	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO493_023245	COG1028	Short-chain dehydrogenase reductase Sdr
IXO493_023265	COG3507	Belongs to the glycosyl hydrolase 43 family
IXO493_023305	COG3162	membrane
IXO493_023310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO493_023330	COG0708	Exodeoxyribonuclease III
IXO493_023345	COG2091	lysine biosynthetic process via aminoadipic acid
IXO493_023355	COG3540	Alkaline phosphatase
IXO493_023360	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO493_023385	COG2159	amidohydrolase
IXO493_023395	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO493_023400	COG0583	DNA-binding transcription factor activity
IXO493_023405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO493_023420	COG0210	DNA helicase
IXO493_023445	COG0531	amino acid
IXO493_023450	COG1322	Protein conserved in bacteria
IXO493_023460	COG0386	Belongs to the glutathione peroxidase family
IXO493_023520	COG0793	Belongs to the peptidase S41A family
IXO493_023525	COG4942	peptidase
IXO493_023535	COG2234	aminopeptidase activity
IXO493_023580	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO493_023585	COG0302	gtp cyclohydrolase
IXO493_023605	COG0477	Major facilitator Superfamily
IXO493_023725	COG3039	Transposase
IXO493_023735	COG1929	Belongs to the glycerate kinase type-1 family
IXO493_023740	COG2271	Major facilitator Superfamily
IXO493_023755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO493_023760	COG0861	Integral membrane protein TerC family
IXO493_023775	COG0584	glycerophosphoryl diester phosphodiesterase
IXO493_023785	COG0671	phosphoesterase, PA-phosphatase related
IXO493_023795	COG0726	polysaccharide deacetylase
IXO493_023800	COG0706	membrane insertase activity