locus-tag	class	description
IXO608_000050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO608_000070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO608_000085	COG1595	DNA-templated transcription, initiation
IXO608_000135	COG2244	polysaccharide biosynthetic process
IXO608_000165	COG2264	protein methyltransferase activity
IXO608_000175	COG0438	transferase activity, transferring glycosyl groups
IXO608_000195	COG1136	(ABC) transporter
IXO608_000200	COG1132	(ABC) transporter
IXO608_000210	COG0477	Major facilitator Superfamily
IXO608_000220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO608_000235	COG1253	flavin adenine dinucleotide binding
IXO608_000245	COG0306	phosphate transporter
IXO608_000250	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IXO608_000275	COG0504	CTP synthase activity
IXO608_000280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO608_000290	COG0148	phosphopyruvate hydratase activity
IXO608_000295	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO608_000310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO608_000320	COG2840	Smr protein MutS2
IXO608_000325	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO608_000330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO608_000335	COG1238	metal cluster binding
IXO608_000350	COG1534	Rna-binding protein
IXO608_000355	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO608_000365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO608_000380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO608_000385	COG1546	Belongs to the CinA family
IXO608_000400	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO608_000405	COG2137	regulation of response to DNA damage stimulus
IXO608_000410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO608_000415	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO608_000435	COG0305	Participates in initiation and elongation during chromosome replication
IXO608_000440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO608_000460	COG1741	Belongs to the pirin family
IXO608_000465	COG0583	DNA-binding transcription factor activity
IXO608_000495	COG0351	phosphomethylpyrimidine kinase
IXO608_000505	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO608_000510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO608_000525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO608_000535	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO608_000540	COG3734	2-keto-3-deoxy-galactonokinase
IXO608_000550	COG4948	Mandelate Racemase Muconate Lactonizing
IXO608_000555	COG0800	Aldolase
IXO608_000570	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO608_000580	COG1070	Carbohydrate kinase
IXO608_000590	COG0477	Major facilitator Superfamily
IXO608_000610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO608_000660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO608_000665	COG2258	MOSC domain
IXO608_000675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO608_000680	COG0505	Belongs to the CarA family
IXO608_000690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO608_000695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO608_000705	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO608_000775	COG0784	Response regulator, receiver
IXO608_000775	COG2198	Histidine kinase
IXO608_000775	COG2205	protein histidine kinase activity
IXO608_000780	COG1024	Enoyl-CoA hydratase
IXO608_000785	COG0318	PFAM AMP-dependent synthetase and ligase
IXO608_000815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO608_000845	COG0840	transmembrane signaling receptor activity
IXO608_000865	COG0835	chemotaxis
IXO608_000890	COG0840	transmembrane signaling receptor activity
IXO608_000895	COG0840	transmembrane signaling receptor activity
IXO608_000900	COG0840	transmembrane signaling receptor activity
IXO608_000910	COG0840	transmembrane signaling receptor activity
IXO608_000920	COG0840	transmembrane signaling receptor activity
IXO608_000930	COG0840	transmembrane signaling receptor activity
IXO608_000950	COG0745	RESPONSE REGULATOR receiver
IXO608_000960	COG0835	chemotaxis
IXO608_000970	COG1360	Flagellar Motor Protein
IXO608_000975	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO608_000995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO608_001005	COG4771	TonB-dependent receptor
IXO608_001035	COG3039	Transposase
IXO608_001175	COG3039	Transposase
IXO608_001190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO608_001190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO608_001195	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO608_001200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO608_001200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO608_001205	COG1609	Transcriptional regulator
IXO608_001225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO608_001230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO608_001240	COG2902	Dehydrogenase
IXO608_001245	COG3039	Transposase
IXO608_001255	COG0784	Response regulator, receiver
IXO608_001255	COG2205	protein histidine kinase activity
IXO608_001255	COG5002	protein histidine kinase activity
IXO608_001260	COG2733	membrane
IXO608_001270	COG1121	(ABC) transporter
IXO608_001275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO608_001285	COG2223	nitrite transmembrane transporter activity
IXO608_001295	COG0243	molybdopterin cofactor binding
IXO608_001305	COG0477	Major facilitator Superfamily
IXO608_001315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO608_001320	COG0174	glutamine synthetase
IXO608_001355	COG3842	ATPase activity
IXO608_001365	COG1177	transmembrane transport
IXO608_001375	COG1012	belongs to the aldehyde dehydrogenase family
IXO608_001390	COG4535	Mg2 and Co2 transporter CorC
IXO608_001410	COG1702	phosphate starvation-inducible protein PhoH
IXO608_001435	COG0741	lytic transglycosylase activity
IXO608_001440	COG0723	plastoquinol--plastocyanin reductase activity
IXO608_001445	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO608_001450	COG2857	Cytochrome c1
IXO608_001455	COG0625	glutathione transferase activity
IXO608_001460	COG2969	positive regulation of protein catabolic process
IXO608_001495	COG3328	transposase activity
IXO608_001570	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO608_001590	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO608_001595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO608_001595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO608_001600	COG0802	atpase or kinase
IXO608_001605	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO608_001610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO608_001630	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_001650	COG2081	HI0933 family
IXO608_001655	COG4681	YaeQ
IXO608_001660	COG1671	Belongs to the UPF0178 family
IXO608_001670	COG0625	glutathione transferase activity
IXO608_001690	COG0513	Belongs to the DEAD box helicase family
IXO608_001695	COG0488	(ABC) transporter
IXO608_001715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO608_001720	COG0483	inositol monophosphate 1-phosphatase activity
IXO608_001735	COG5001	Diguanylate cyclase
IXO608_001735	COG3300	MHYT domain
IXO608_001740	COG1509	lysine 2,3-aminomutase activity
IXO608_001755	COG0402	S-adenosylhomocysteine deaminase activity
IXO608_001760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO608_001785	COG4677	pectinesterase activity
IXO608_001795	COG3039	Transposase
IXO608_001830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO608_001855	COG2166	iron-sulfur cluster assembly
IXO608_001870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO608_001875	COG0137	argininosuccinate synthase activity
IXO608_001885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO608_001890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO608_001905	COG0165	Argininosuccinate lyase
IXO608_001925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO608_001960	COG1271	oxidase subunit
IXO608_001980	COG4988	ABC transporter
IXO608_001985	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO608_002070	COG3039	Transposase
IXO608_002080	COG3039	Transposase
IXO608_002125	COG2198	Histidine kinase
IXO608_002125	COG0784	Response regulator, receiver
IXO608_002125	COG0643	Histidine kinase
IXO608_002180	COG1684	flagellar biosynthetic protein fliR
IXO608_002195	COG3190	flagellar
IXO608_002245	COG1677	Flagellar hook-basal body complex protein FliE
IXO608_002275	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_002285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO608_002305	COG2201	protein-glutamate methylesterase activity
IXO608_002335	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO608_002340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO608_002375	COG4787	bacterial-type flagellum-dependent cell motility
IXO608_002385	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO608_002390	COG1558	bacterial-type flagellum-dependent cell motility
IXO608_002400	COG0835	chemotaxis
IXO608_002400	COG0784	Response regulator, receiver
IXO608_002420	COG5002	protein histidine kinase activity
IXO608_002430	COG4585	Histidine kinase
IXO608_002435	COG5001	Diguanylate cyclase
IXO608_002460	COG0482	sulfurtransferase activity
IXO608_002475	COG0542	response to heat
IXO608_002500	COG0492	ferredoxin-NADP+ reductase activity
IXO608_002505	COG1674	ftsk spoiiie
IXO608_002525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO608_002545	COG0038	chloride channel
IXO608_002550	COG0183	Belongs to the thiolase family
IXO608_002555	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO608_002555	COG1024	Enoyl-CoA hydratase
IXO608_002570	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO608_002580	COG1426	Protein conserved in bacteria
IXO608_002590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO608_002600	COG0303	'Molybdopterin
IXO608_002630	COG3039	Transposase
IXO608_002640	COG3039	Transposase
IXO608_002670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO608_002690	COG0742	ribosomal rna small subunit methyltransferase
IXO608_002695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO608_002705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO608_002710	COG0405	Gamma-glutamyltransferase
IXO608_002790	COG0343	queuine tRNA-ribosyltransferase activity
IXO608_002795	COG1862	Preprotein translocase
IXO608_002800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO608_002805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO608_002835	COG3328	transposase activity
IXO608_002850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO608_002860	COG0704	Plays a role in the regulation of phosphate uptake
IXO608_002875	COG0573	inorganic phosphate transmembrane transporter activity
IXO608_002880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO608_002920	COG3039	Transposase
IXO608_002935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO608_002945	COG1024	Enoyl-CoA hydratase
IXO608_002955	COG0494	nUDIX hydrolase
IXO608_003000	COG0116	Belongs to the methyltransferase superfamily
IXO608_003000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO608_003025	COG0667	Aldo Keto reductase
IXO608_003035	COG2925	Exonuclease
IXO608_003060	COG0288	reversible hydration of carbon dioxide
IXO608_003090	COG0316	Belongs to the HesB IscA family
IXO608_003095	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO608_003105	COG0359	binds to the 23S rRNA
IXO608_003115	COG3115	cell septum assembly
IXO608_003130	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO608_003145	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO608_003170	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO608_003180	COG2986	histidine ammonia-lyase
IXO608_003185	COG1228	amidohydrolase
IXO608_003225	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO608_003230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IXO608_003235	COG0077	Prephenate dehydratase
IXO608_003235	COG1605	Chorismate mutase
IXO608_003240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO608_003270	COG4566	intracellular signal transduction
IXO608_003315	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO608_003320	COG1469	GTP cyclohydrolase I activity
IXO608_003330	COG0617	tRNA 3'-terminal CCA addition
IXO608_003375	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO608_003390	COG2203	Gaf domain
IXO608_003390	COG5001	Diguanylate cyclase
IXO608_003390	COG4251	negative regulation of phosphorylation
IXO608_003390	COG3706	GGDEF domain
IXO608_003475	COG0386	Belongs to the glutathione peroxidase family
IXO608_003555	COG2205	protein histidine kinase activity
IXO608_003555	COG5002	protein histidine kinase activity
IXO608_003555	COG0784	Response regulator, receiver
IXO608_003585	COG0800	Aldolase
IXO608_003590	COG0129	dihydroxy-acid dehydratase activity
IXO608_003595	COG0363	glucosamine-6-phosphate deaminase activity
IXO608_003605	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO608_003620	COG0354	folic acid binding
IXO608_003635	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO608_003650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO608_003665	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO608_003690	COG0811	peptide transport
IXO608_003705	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO608_003715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO608_003725	COG0322	excinuclease ABC activity
IXO608_003760	COG3328	transposase activity
IXO608_003780	COG3039	Transposase
IXO608_003795	COG2801	Transposase and inactivated derivatives
IXO608_003900	COG0653	protein targeting
IXO608_003940	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO608_003940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO608_003950	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO608_003960	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO608_003960	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO608_003975	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO608_003995	COG0124	histidyl-tRNA synthetase
IXO608_004010	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO608_004045	COG1012	belongs to the aldehyde dehydrogenase family
IXO608_004065	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IXO608_004070	COG0697	spore germination
IXO608_004075	COG1794	racemase activity, acting on amino acids and derivatives
IXO608_004090	COG0671	phosphoesterase, PA-phosphatase related
IXO608_004105	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO608_004120	COG2183	response to ionizing radiation
IXO608_004130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO608_004130	COG0723	plastoquinol--plastocyanin reductase activity
IXO608_004145	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO608_004155	COG1183	phosphatidylcholine synthase activity
IXO608_004160	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_004185	COG0668	transmembrane transport
IXO608_004205	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO608_004225	COG0583	DNA-binding transcription factor activity
IXO608_004255	COG0583	DNA-binding transcription factor activity
IXO608_004260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO608_004265	COG3002	Belongs to the UPF0753 family
IXO608_004280	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO608_004300	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO608_004310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO608_004315	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO608_004325	COG0776	regulation of translation
IXO608_004330	COG0539	negative regulation of cytoplasmic translation
IXO608_004335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO608_004350	COG2957	Belongs to the agmatine deiminase family
IXO608_004360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO608_004385	COG0395	ABC-type sugar transport system, permease component
IXO608_004390	COG1175	transmembrane transport
IXO608_004420	COG2350	Protein conserved in bacteria
IXO608_004425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO608_004430	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO608_004435	COG1187	pseudouridine synthase activity
IXO608_004460	COG0436	Aminotransferase
IXO608_004525	COG0277	FAD linked oxidase domain protein
IXO608_004530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO608_004540	COG0531	amino acid
IXO608_004545	COG0531	amino acid
IXO608_004555	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO608_004585	COG2201	protein-glutamate methylesterase activity
IXO608_004630	COG0583	DNA-binding transcription factor activity
IXO608_004640	COG3039	Transposase
IXO608_004690	COG3039	Transposase
IXO608_004740	COG3039	Transposase
IXO608_004755	COG1278	Cold shock
IXO608_004765	COG3328	transposase activity
IXO608_004785	COG3039	Transposase
IXO608_004795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO608_004815	COG0557	exoribonuclease II activity
IXO608_004840	COG1960	acyl-CoA dehydrogenase activity
IXO608_004845	COG2226	methyltransferase
IXO608_004850	COG0646	methionine synthase
IXO608_004850	COG1410	methionine synthase
IXO608_004855	COG0646	methionine synthase
IXO608_004855	COG1410	methionine synthase
IXO608_004865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO608_004875	COG1609	Transcriptional regulator
IXO608_004890	COG2900	Belongs to the SlyX family
IXO608_004905	COG0386	Belongs to the glutathione peroxidase family
IXO608_004915	COG1725	Transcriptional regulator
IXO608_004920	COG1131	(ABC) transporter
IXO608_005000	COG2850	peptidyl-arginine hydroxylation
IXO608_005035	COG1132	(ABC) transporter
IXO608_005050	COG0583	DNA-binding transcription factor activity
IXO608_005065	COG0287	Prephenate dehydrogenase
IXO608_005065	COG1605	Chorismate mutase
IXO608_005070	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO608_005075	COG0484	heat shock protein binding
IXO608_005080	COG0443	Heat shock 70 kDa protein
IXO608_005085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO608_005095	COG0497	DNA recombination
IXO608_005105	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO608_005110	COG2914	Belongs to the UPF0125 (RnfH) family
IXO608_005135	COG1960	acyl-CoA dehydrogenase activity
IXO608_005145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO608_005190	COG2814	Major facilitator Superfamily
IXO608_005195	COG1566	PFAM secretion protein HlyD family protein
IXO608_005230	COG4774	siderophore transport
IXO608_005240	COG0367	asparagine synthase
IXO608_005255	COG1393	Belongs to the ArsC family
IXO608_005315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO608_005330	COG0233	cytoplasmic translational termination
IXO608_005340	COG0575	Belongs to the CDS family
IXO608_005350	COG0750	zinc metalloprotease
IXO608_005365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO608_005370	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO608_005390	COG0825	malonyl-CoA metabolic process
IXO608_005400	COG4771	TonB-dependent receptor
IXO608_005405	COG1131	(ABC) transporter
IXO608_005430	COG1981	membrane
IXO608_005475	COG0529	Catalyzes the synthesis of activated sulfate
IXO608_005475	COG2895	sulfate adenylyltransferase (ATP) activity
IXO608_005510	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO608_005525	COG2040	homocysteine
IXO608_005530	COG0833	amino acid
IXO608_005550	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO608_005550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO608_005560	COG2878	Part of a membrane complex involved in electron transport
IXO608_005575	COG1595	DNA-templated transcription, initiation
IXO608_005600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO608_005615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO608_005620	COG0251	oxidation-reduction process
IXO608_005630	COG0392	lysyltransferase activity
IXO608_005630	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO608_005675	COG2814	Major facilitator Superfamily
IXO608_005680	COG1902	pentaerythritol trinitrate reductase activity
IXO608_005690	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO608_005705	COG1047	Peptidyl-prolyl cis-trans
IXO608_005740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO608_005755	COG1451	nucleotide metabolic process
IXO608_005780	COG0183	Belongs to the thiolase family
IXO608_005810	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO608_005810	COG1793	dna ligase
IXO608_005820	COG1793	dna ligase
IXO608_005825	COG1201	RNA secondary structure unwinding
IXO608_005845	COG1278	Cold shock
IXO608_005850	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO608_005855	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO608_005865	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO608_005870	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IXO608_005875	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO608_005890	COG2954	triphosphatase activity
IXO608_005905	COG1381	Involved in DNA repair and RecF pathway recombination
IXO608_005935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO608_005950	COG1024	Enoyl-CoA hydratase
IXO608_005950	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO608_005970	COG1024	Enoyl-CoA hydratase
IXO608_005975	COG1960	acyl-CoA dehydrogenase activity
IXO608_005995	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IXO608_006045	COG2353	YceI-like domain
IXO608_006055	COG2353	YceI-like domain
IXO608_006070	COG1760	l-serine dehydratase
IXO608_006080	COG0626	cystathionine gamma-synthase activity
IXO608_006085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO608_006090	COG0739	heme binding
IXO608_006100	COG1272	protein, Hemolysin III
IXO608_006120	COG0463	Glycosyl transferase, family 2
IXO608_006130	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO608_006140	COG4771	TonB-dependent receptor
IXO608_006145	COG1309	transcriptional regulator
IXO608_006155	COG1960	acyl-CoA dehydrogenase activity
IXO608_006190	COG0509	glycine decarboxylation via glycine cleavage system
IXO608_006205	COG0330	HflC and HflK could
IXO608_006220	COG3956	TIGRFAM MazG family protein
IXO608_006230	COG0494	nUDIX hydrolase
IXO608_006240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO608_006245	COG0837	glucose binding
IXO608_006260	COG1388	LysM domain
IXO608_006260	COG3858	chitin binding
IXO608_006270	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO608_006280	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO608_006350	COG3537	Alpha-1,2-mannosidase
IXO608_006400	COG3142	Participates in the control of copper homeostasis
IXO608_006405	COG1446	asparaginase
IXO608_006440	COG2198	Histidine kinase
IXO608_006440	COG0643	Histidine kinase
IXO608_006440	COG0784	Response regulator, receiver
IXO608_006445	COG0840	transmembrane signaling receptor activity
IXO608_006450	COG0835	chemotaxis
IXO608_006465	COG0189	ligase activity
IXO608_006475	COG1397	ADP-ribosylglycohydrolase
IXO608_006485	COG1199	ATP-dependent helicase activity
IXO608_006495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO608_006500	COG1215	transferase activity, transferring glycosyl groups
IXO608_006510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO608_006565	COG1643	Atp-dependent helicase
IXO608_006570	COG0783	Belongs to the Dps family
IXO608_006575	COG0514	ATP-dependent DNA helicase (RecQ)
IXO608_006595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO608_006645	COG1187	pseudouridine synthase activity
IXO608_006650	COG0602	queuosine metabolic process
IXO608_006660	COG2885	chlorophyll binding
IXO608_006675	COG0848	biopolymer transport protein
IXO608_006685	COG0824	Thioesterase
IXO608_006690	COG2255	four-way junction helicase activity
IXO608_006700	COG0632	four-way junction helicase activity
IXO608_006805	COG3209	COG3209 Rhs family protein
IXO608_006805	COG3209	COG3209 Rhs family protein
IXO608_006825	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO608_006830	COG1845	cytochrome c oxidase, subunit III
IXO608_006835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO608_006850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO608_006855	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO608_006865	COG0196	riboflavin kinase activity
IXO608_006870	COG0728	peptidoglycan biosynthetic process
IXO608_006875	COG0268	Binds directly to 16S ribosomal RNA
IXO608_006880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO608_006885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO608_006895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO608_006900	COG0824	Thioesterase
IXO608_006915	COG1946	Acyl-CoA thioesterase
IXO608_006925	COG1595	DNA-templated transcription, initiation
IXO608_006940	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO608_006980	COG1877	trehalose-phosphatase activity
IXO608_006985	COG3387	PFAM Glycoside hydrolase 15-related
IXO608_007010	COG0564	pseudouridine synthase activity
IXO608_007015	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO608_007020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO608_007020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO608_007030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO608_007035	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO608_007075	COG2194	sulfuric ester hydrolase activity
IXO608_007080	COG4969	Belongs to the N-Me-Phe pilin family
IXO608_007090	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO608_007125	COG3039	Transposase
IXO608_007150	COG3039	Transposase
IXO608_007180	COG1132	(ABC) transporter
IXO608_007210	COG0745	RESPONSE REGULATOR receiver
IXO608_007215	COG5000	phosphorelay sensor kinase activity
IXO608_007215	COG5002	protein histidine kinase activity
IXO608_007220	COG0475	glutathione-regulated potassium exporter activity
IXO608_007230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO608_007250	COG1187	pseudouridine synthase activity
IXO608_007255	COG5001	Diguanylate cyclase
IXO608_007255	COG5002	protein histidine kinase activity
IXO608_007315	COG3039	Transposase
IXO608_007360	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_007375	COG0415	Belongs to the DNA photolyase family
IXO608_007380	COG0305	Participates in initiation and elongation during chromosome replication
IXO608_007390	COG0367	asparagine synthase
IXO608_007405	COG1960	acyl-CoA dehydrogenase activity
IXO608_007420	COG0084	hydrolase, TatD family'
IXO608_007425	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO608_007485	COG0735	belongs to the Fur family
IXO608_007490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO608_007520	COG3039	Transposase
IXO608_007580	COG2205	protein histidine kinase activity
IXO608_007590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO608_007600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO608_007615	COG0643	Histidine kinase
IXO608_007615	COG2198	Histidine kinase
IXO608_007620	COG0840	transmembrane signaling receptor activity
IXO608_007625	COG0835	chemotaxis
IXO608_007630	COG2202	Pas domain
IXO608_007630	COG2199	diguanylate cyclase activity
IXO608_007630	COG2200	EAL domain
IXO608_007635	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO608_007650	COG3590	peptidase
IXO608_007670	COG1515	deoxyribonuclease V activity
IXO608_007680	COG1741	Belongs to the pirin family
IXO608_007780	COG3039	Transposase
IXO608_007810	COG1741	Belongs to the pirin family
IXO608_007815	COG1966	Carbon starvation protein
IXO608_007820	COG2879	small protein
IXO608_007855	COG4251	negative regulation of phosphorylation
IXO608_007855	COG3706	GGDEF domain
IXO608_007855	COG2203	Gaf domain
IXO608_007855	COG5001	Diguanylate cyclase
IXO608_007860	COG0629	single-stranded DNA binding
IXO608_007865	COG0142	geranyltranstransferase activity
IXO608_007890	COG0527	aspartate kinase activity
IXO608_007900	COG0384	phenazine biosynthesis protein PhzF
IXO608_007910	COG1764	response to oxidative stress
IXO608_007925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO608_007930	COG1678	Uncharacterized ACR, COG1678
IXO608_007940	COG0519	Catalyzes the synthesis of GMP from XMP
IXO608_007970	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO608_008010	COG0693	protein deglycase activity
IXO608_008030	COG1959	2 iron, 2 sulfur cluster binding
IXO608_008035	COG0719	Fe-S assembly protein
IXO608_008040	COG0396	ATPase activity
IXO608_008045	COG0719	Fe-S assembly protein
IXO608_008050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO608_008060	COG2146	nitrite reductase [NAD(P)H] activity
IXO608_008100	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO608_008115	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO608_008125	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO608_008130	COG0174	glutamine synthetase
IXO608_008135	COG3328	transposase activity
IXO608_008160	COG0326	Molecular chaperone. Has ATPase activity
IXO608_008165	COG2207	Transcriptional regulator
IXO608_008195	COG0657	acetylesterase activity
IXO608_008195	COG2755	lipolytic protein G-D-S-L family
IXO608_008220	COG0488	(ABC) transporter
IXO608_008255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO608_008255	COG4651	solute:proton antiporter activity
IXO608_008270	COG4772	TonB-dependent receptor
IXO608_008280	COG4264	IucA IucC family
IXO608_008285	COG2814	Major facilitator Superfamily
IXO608_008295	COG0019	diaminopimelate decarboxylase activity
IXO608_008355	COG4206	TonB-dependent receptor
IXO608_008390	COG0542	response to heat
IXO608_008425	COG0534	Mate efflux family protein
IXO608_008440	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO608_008445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO608_008450	COG0228	four-way junction DNA binding
IXO608_008470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO608_008480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO608_008485	COG3039	Transposase
IXO608_008530	COG1555	photosystem II stabilization
IXO608_008535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO608_008550	COG3178	'Phosphotransferase
IXO608_008555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO608_008565	COG0628	permease
IXO608_008575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO608_008590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO608_008610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO608_008615	COG0271	Belongs to the BolA IbaG family
IXO608_008625	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO608_008635	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO608_008640	COG1137	ATPase activity
IXO608_008655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO608_008660	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO608_008665	COG1660	Displays ATPase and GTPase activities
IXO608_008675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO608_008680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO608_008685	COG2239	Acts as a magnesium transporter
IXO608_008695	COG1294	oxidase, subunit
IXO608_008700	COG1271	oxidase subunit
IXO608_008715	COG1113	amino acid transport
IXO608_008730	COG2197	response regulator
IXO608_008735	COG0531	amino acid
IXO608_008790	COG0754	glutathionylspermidine amidase activity
IXO608_008815	COG1842	Phage shock protein A
IXO608_008830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO608_008875	COG2201	protein-glutamate methylesterase activity
IXO608_008915	COG2801	Transposase and inactivated derivatives
IXO608_008980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO608_008985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO608_009025	COG0745	RESPONSE REGULATOR receiver
IXO608_009030	COG2205	protein histidine kinase activity
IXO608_009050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO608_009080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO608_009080	COG3453	Protein conserved in bacteria
IXO608_009085	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO608_009090	COG4149	molybdate abc transporter
IXO608_009095	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO608_009115	COG0642	Histidine kinase
IXO608_009130	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_009140	COG1022	Amp-dependent synthetase and ligase
IXO608_009165	COG1376	ErfK ybiS ycfS ynhG family protein
IXO608_009170	COG0739	heme binding
IXO608_009180	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO608_009185	COG1301	dicarboxylic acid transport
IXO608_009205	COG2304	oxidoreductase activity
IXO608_009225	COG0714	Associated with various cellular activities
IXO608_009275	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO608_009300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO608_009310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO608_009335	COG1561	YicC-like family, N-terminal region
IXO608_009340	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO608_009355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO608_009395	COG0006	proline dipeptidase activity
IXO608_009420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO608_009440	COG2912	Transglutaminase-like superfamily
IXO608_009445	COG1773	rubredoxin
IXO608_009450	COG0352	thiamine-phosphate diphosphorylase activity
IXO608_009480	COG0280	phosphate acetyltransferase
IXO608_009480	COG0281	malic enzyme
IXO608_009500	COG4191	Histidine kinase
IXO608_009515	COG0583	DNA-binding transcription factor activity
IXO608_009530	COG2197	response regulator
IXO608_009540	COG0642	Histidine kinase
IXO608_009555	COG2851	Citrate transporter
IXO608_009560	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_009565	COG1609	Transcriptional regulator
IXO608_009575	COG2211	Major facilitator Superfamily
IXO608_009625	COG0726	polysaccharide deacetylase
IXO608_009630	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO608_009655	COG3039	Transposase
IXO608_009700	COG0242	peptide deformylase activity
IXO608_009720	COG0714	Associated with various cellular activities
IXO608_009740	COG0537	adenosine 5'-monophosphoramidase activity
IXO608_009770	COG0314	molybdopterin synthase activity
IXO608_009775	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO608_009780	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO608_009790	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO608_009795	COG1234	tRNA 3'-trailer cleavage
IXO608_009800	COG3642	lipopolysaccharide core region biosynthetic process
IXO608_009805	COG0859	PFAM glycosyl transferase family 9
IXO608_009815	COG0582	viral genome integration into host DNA
IXO608_009900	COG0631	protein serine/threonine phosphatase activity
IXO608_009910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO608_009935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO608_009975	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO608_010025	COG0473	3-isopropylmalate dehydrogenase activity
IXO608_010050	COG0584	glycerophosphoryl diester phosphodiesterase
IXO608_010070	COG3039	Transposase
IXO608_010200	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO608_010220	COG1217	gtp-binding protein TYPA
IXO608_010225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO608_010230	COG0039	L-malate dehydrogenase activity
IXO608_010235	COG0625	glutathione transferase activity
IXO608_010250	COG3781	membrane
IXO608_010260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO608_010290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO608_010310	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO608_010335	COG3710	Transcriptional regulator
IXO608_010340	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO608_010350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO608_010385	COG0066	3-isopropylmalate dehydratase activity
IXO608_010390	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO608_010415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO608_010420	COG1538	Outer membrane efflux protein
IXO608_010425	COG1519	Transferase
IXO608_010430	COG1560	Kdo2-lipid A biosynthetic process
IXO608_010475	COG0308	aminopeptidase N
IXO608_010490	COG0330	HflC and HflK could
IXO608_010495	COG0330	HflC and HflK could
IXO608_010515	COG0678	peroxiredoxin activity
IXO608_010525	COG2826	transposase and inactivated derivatives, IS30 family
IXO608_010570	COG3039	Transposase
IXO608_010600	COG3829	transcription factor binding
IXO608_010635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO608_010640	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO608_010650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO608_010655	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_010680	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO608_010720	COG1518	maintenance of DNA repeat elements
IXO608_010725	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO608_010775	COG2188	Transcriptional regulator
IXO608_010790	COG1450	Type ii and iii secretion system protein
IXO608_010805	COG3166	PFAM Fimbrial assembly family protein
IXO608_010810	COG3156	type II secretion system protein K
IXO608_010815	COG4795	General secretion pathway protein
IXO608_010820	COG2165	general secretion pathway protein
IXO608_010825	COG4970	Tfp pilus assembly protein FimT
IXO608_010830	COG2165	general secretion pathway protein
IXO608_010835	COG1459	type II secretion system
IXO608_010845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO608_010850	COG1404	Belongs to the peptidase S8 family
IXO608_010875	COG5295	Hep Hag repeat protein
IXO608_010885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO608_010890	COG4974	Belongs to the 'phage' integrase family
IXO608_010900	COG0795	lipopolysaccharide-transporting ATPase activity
IXO608_010910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO608_010925	COG0525	valine-tRNA ligase activity
IXO608_010980	COG3039	Transposase
IXO608_011005	COG1183	phosphatidylcholine synthase activity
IXO608_011015	COG0442	prolyl-tRNA aminoacylation
IXO608_011030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO608_011035	COG1127	ABC transporter
IXO608_011040	COG3218	ABC-type transport auxiliary lipoprotein component
IXO608_011040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO608_011075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO608_011080	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO608_011080	COG0662	Cupin 2, conserved barrel domain protein
IXO608_011105	COG2086	electron transfer activity
IXO608_011130	COG3328	transposase activity
IXO608_011170	COG0626	cystathionine gamma-synthase activity
IXO608_011210	COG0513	Belongs to the DEAD box helicase family
IXO608_011215	COG0720	synthase
IXO608_011225	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO608_011230	COG1956	GAF domain-containing protein
IXO608_011265	COG0339	signal peptide processing
IXO608_011320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO608_011325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO608_011380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO608_011385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO608_011390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO608_011400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO608_011410	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO608_011430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO608_011440	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO608_011470	COG2011	ABC-type metal ion transport system permease component
IXO608_011480	COG0697	spore germination
IXO608_011515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO608_011520	COG1187	pseudouridine synthase activity
IXO608_011525	COG2813	Specifically methylates the guanine in position
IXO608_011555	COG2202	Pas domain
IXO608_011555	COG2205	protein histidine kinase activity
IXO608_011580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO608_011630	COG0745	RESPONSE REGULATOR receiver
IXO608_011645	COG1404	Belongs to the peptidase S8 family
IXO608_011665	COG0842	Transport permease protein
IXO608_011670	COG1131	(ABC) transporter
IXO608_011675	COG0025	NhaP-type Na H and K H
IXO608_011685	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO608_011695	COG1573	uracil-dna glycosylase
IXO608_011705	COG3384	dioxygenase
IXO608_011720	COG0667	Aldo Keto reductase
IXO608_011735	COG3590	peptidase
IXO608_011755	COG0531	amino acid
IXO608_011770	COG2972	Histidine kinase
IXO608_011795	COG2204	response regulator
IXO608_011805	COG1271	oxidase subunit
IXO608_011810	COG1294	oxidase, subunit
IXO608_011955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO608_011965	COG1560	Kdo2-lipid A biosynthetic process
IXO608_012015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO608_012015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO608_012020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO608_012025	COG0242	peptide deformylase activity
IXO608_012030	COG1652	LysM domain
IXO608_012035	COG0758	DNA mediated transformation
IXO608_012040	COG2922	Belongs to the Smg family
IXO608_012055	COG1754	DNA topoisomerase type I activity
IXO608_012055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO608_012060	COG0009	L-threonylcarbamoyladenylate synthase
IXO608_012075	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_012085	COG0616	signal peptide processing
IXO608_012090	COG0534	Mate efflux family protein
IXO608_012110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO608_012145	COG1324	tolerance protein
IXO608_012155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO608_012160	COG0511	ligase activity, forming carbon-carbon bonds
IXO608_012170	COG0439	Biotin carboxylase
IXO608_012215	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO608_012235	COG2267	carboxylic ester hydrolase activity
IXO608_012240	COG2267	carboxylic ester hydrolase activity
IXO608_012255	COG0419	ATPase involved in DNA repair
IXO608_012265	COG0151	Belongs to the GarS family
IXO608_012270	COG0577	efflux transmembrane transporter activity
IXO608_012270	COG1136	(ABC) transporter
IXO608_012280	COG1289	transmembrane transporter activity
IXO608_012295	COG2814	Major facilitator Superfamily
IXO608_012310	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO608_012345	COG0745	RESPONSE REGULATOR receiver
IXO608_012390	COG0739	heme binding
IXO608_012405	COG2211	Major facilitator Superfamily
IXO608_012410	COG0708	Exodeoxyribonuclease III
IXO608_012425	COG1192	Involved in chromosome partitioning
IXO608_012430	COG1475	DNA binding
IXO608_012445	COG0463	Glycosyl transferase, family 2
IXO608_012470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO608_012495	COG4221	oxidoreductase activity
IXO608_012520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO608_012525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO608_012540	COG3485	protocatechuate 3,4-dioxygenase
IXO608_012545	COG3485	protocatechuate 3,4-dioxygenase
IXO608_012580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO608_012585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO608_012595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO608_012595	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO608_012595	COG1042	CoA-binding domain protein
IXO608_012610	COG2239	Acts as a magnesium transporter
IXO608_012625	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO608_012630	COG3387	PFAM Glycoside hydrolase 15-related
IXO608_012645	COG3100	YcgL domain-containing protein
IXO608_012650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO608_012660	COG0463	Glycosyl transferase, family 2
IXO608_012675	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_012685	COG0156	8-amino-7-oxononanoate synthase activity
IXO608_012690	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO608_012695	COG1040	competence protein
IXO608_012700	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO608_012710	COG0628	permease
IXO608_012720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO608_012730	COG1595	DNA-templated transcription, initiation
IXO608_012735	COG0753	catalase activity
IXO608_012780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO608_012785	COG0180	Tryptophanyl-tRNA synthetase
IXO608_012790	COG3237	CsbD-like
IXO608_012825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO608_012840	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO608_012845	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO608_012845	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO608_012885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO608_012905	COG1566	PFAM secretion protein HlyD family protein
IXO608_012925	COG1199	ATP-dependent helicase activity
IXO608_012965	COG0583	DNA-binding transcription factor activity
IXO608_013010	COG0625	glutathione transferase activity
IXO608_013050	COG4555	ABC transporter
IXO608_013060	COG1476	TRANSCRIPTIONal
IXO608_013080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO608_013085	COG1131	(ABC) transporter
IXO608_013090	COG0842	Transport permease protein
IXO608_013100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO608_013170	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO608_013180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO608_013190	COG0564	pseudouridine synthase activity
IXO608_013220	COG0339	signal peptide processing
IXO608_013250	COG3254	rhamnose metabolic process
IXO608_013255	COG0738	Major facilitator superfamily
IXO608_013260	COG1414	Transcriptional regulator
IXO608_013270	COG2205	protein histidine kinase activity
IXO608_013280	COG3459	Glycosyltransferase 36 associated
IXO608_013285	COG2211	Major facilitator Superfamily
IXO608_013290	COG3265	gluconokinase activity
IXO608_013300	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO608_013375	COG1127	ABC transporter
IXO608_013380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO608_013385	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO608_013400	COG2853	Lipoprotein
IXO608_013420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO608_013485	COG0676	glucose-6-phosphate 1-epimerase activity
IXO608_013490	COG3039	Transposase
IXO608_013515	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO608_013525	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO608_013535	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO608_013540	COG1064	alcohol dehydrogenase
IXO608_013585	COG1522	sequence-specific DNA binding
IXO608_013590	COG3186	Phenylalanine-4-hydroxylase
IXO608_013630	COG2937	Belongs to the GPAT DAPAT family
IXO608_013665	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO608_013670	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO608_013675	COG3132	Protein of unknown function, DUF480
IXO608_013690	COG0210	DNA helicase
IXO608_013705	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO608_013730	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_013755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO608_013815	COG1166	arginine decarboxylase activity
IXO608_013820	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO608_013860	COG0606	chelatase, subunit chli
IXO608_013905	COG0366	Alpha amylase catalytic
IXO608_013910	COG0366	Alpha amylase catalytic
IXO608_013940	COG1609	Transcriptional regulator
IXO608_013985	COG2032	superoxide dismutase activity
IXO608_013990	COG2032	superoxide dismutase activity
IXO608_013995	COG2204	response regulator
IXO608_014000	COG3852	Histidine kinase
IXO608_014005	COG0004	ammonium transporteR
IXO608_014010	COG0347	Belongs to the P(II) protein family
IXO608_014015	COG0174	glutamine synthetase
IXO608_014020	COG1968	undecaprenyl-diphosphatase activity
IXO608_014065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO608_014075	COG2062	phosphohistidine phosphatase, SixA
IXO608_014080	COG0489	protein tyrosine kinase activity
IXO608_014100	COG1396	sequence-specific DNA binding
IXO608_014105	COG3550	peptidyl-serine autophosphorylation
IXO608_014110	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO608_014115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO608_014130	COG0517	IMP dehydrogenase activity
IXO608_014130	COG1125	glycine betaine transport
IXO608_014145	COG1119	ATPase activity
IXO608_014155	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO608_014170	COG3039	Transposase
IXO608_014195	COG0656	L-ascorbic acid biosynthetic process
IXO608_014200	COG2130	NADP-dependent
IXO608_014205	COG0667	Aldo Keto reductase
IXO608_014215	COG1187	pseudouridine synthase activity
IXO608_014225	COG1643	Atp-dependent helicase
IXO608_014230	COG4807	Protein conserved in bacteria
IXO608_014235	COG4948	Mandelate Racemase Muconate Lactonizing
IXO608_014240	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO608_014245	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_014265	COG3507	Belongs to the glycosyl hydrolase 43 family
IXO608_014305	COG3162	membrane
IXO608_014310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO608_014325	COG0708	Exodeoxyribonuclease III
IXO608_014340	COG2091	lysine biosynthetic process via aminoadipic acid
IXO608_014350	COG3540	Alkaline phosphatase
IXO608_014380	COG2159	amidohydrolase
IXO608_014400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO608_014405	COG0583	DNA-binding transcription factor activity
IXO608_014410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO608_014425	COG0210	DNA helicase
IXO608_014440	COG0531	amino acid
IXO608_014445	COG1322	Protein conserved in bacteria
IXO608_014455	COG0386	Belongs to the glutathione peroxidase family
IXO608_014505	COG0793	Belongs to the peptidase S41A family
IXO608_014510	COG4942	peptidase
IXO608_014520	COG2234	aminopeptidase activity
IXO608_014565	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO608_014570	COG0302	gtp cyclohydrolase
IXO608_014595	COG0477	Major facilitator Superfamily
IXO608_014605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO608_014690	COG1929	Belongs to the glycerate kinase type-1 family
IXO608_014695	COG2271	Major facilitator Superfamily
IXO608_014710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO608_014715	COG0861	Integral membrane protein TerC family
IXO608_014725	COG0584	glycerophosphoryl diester phosphodiesterase
IXO608_014735	COG0671	phosphoesterase, PA-phosphatase related
IXO608_014745	COG0726	polysaccharide deacetylase
IXO608_014765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO608_014780	COG0187	DNA topoisomerase II activity
IXO608_014790	COG0501	Belongs to the peptidase M48B family
IXO608_014830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO608_014840	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO608_014850	COG4772	TonB-dependent receptor
IXO608_014865	COG3039	Transposase
IXO608_014870	COG1304	FMN binding
IXO608_014875	COG1755	Isoprenylcysteine carboxyl methyltransferase
IXO608_014900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO608_014910	COG3039	Transposase
IXO608_014920	COG1136	(ABC) transporter
IXO608_014965	COG3039	Transposase
IXO608_014970	COG0513	Belongs to the DEAD box helicase family
IXO608_015055	COG1858	cytochrome C peroxidase
IXO608_015070	COG0702	epimerase
IXO608_015095	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO608_015115	COG1649	PFAM Uncharacterised BCR, COG1649
IXO608_015120	COG2354	Protein conserved in bacteria
IXO608_015125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO608_015140	COG1511	domain protein
IXO608_015140	COG3264	Mechanosensitive ion channel
IXO608_015215	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO608_015325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO608_015335	COG0642	Histidine kinase
IXO608_015345	COG1090	epimerase
IXO608_015375	COG2826	transposase and inactivated derivatives, IS30 family
IXO608_015440	COG1136	(ABC) transporter
IXO608_015485	COG1272	protein, Hemolysin III
IXO608_015490	COG1111	helicase
IXO608_015490	COG1205	dead DEAH box helicase
IXO608_015550	COG0067	glutamate synthase
IXO608_015550	COG0069	glutamate synthase activity
IXO608_015550	COG0070	glutamate synthase
IXO608_015555	COG0493	'glutamate synthase
IXO608_015605	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO608_015610	COG1074	ATP-dependent DNA helicase activity
IXO608_015620	COG3549	Plasmid maintenance system killer
IXO608_015695	COG1764	response to oxidative stress
IXO608_015700	COG1846	Transcriptional regulator
IXO608_015745	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IXO608_015790	COG2211	Major facilitator Superfamily
IXO608_015810	COG3693	PFAM glycoside hydrolase, family 10
IXO608_015835	COG0246	Mannitol dehydrogenase
IXO608_015840	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO608_015850	COG4948	Mandelate Racemase Muconate Lactonizing
IXO608_015860	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO608_015905	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO608_015915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO608_015925	COG0805	protein transport
IXO608_015935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO608_015935	COG0519	Catalyzes the synthesis of GMP from XMP
IXO608_015950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO608_015965	COG0457	Tetratricopeptide repeat
IXO608_015970	COG4771	TonB-dependent receptor
IXO608_015985	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO608_015995	COG0697	spore germination
IXO608_016005	COG0523	cobalamin synthesis protein
IXO608_016060	COG1960	acyl-CoA dehydrogenase activity
IXO608_016065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO608_016070	COG4770	biotin carboxylase activity
IXO608_016120	COG2072	flavoprotein involved in K transport
IXO608_016140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO608_016190	COG0084	hydrolase, TatD family'
IXO608_016205	COG0583	DNA-binding transcription factor activity
IXO608_016210	COG2814	Major facilitator Superfamily
IXO608_016220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO608_016225	COG1902	pentaerythritol trinitrate reductase activity
IXO608_016255	COG0745	RESPONSE REGULATOR receiver
IXO608_016275	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO608_016280	COG0583	DNA-binding transcription factor activity
IXO608_016310	COG0702	epimerase
IXO608_016315	COG1733	regulation of RNA biosynthetic process
IXO608_016365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO608_016380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO608_016415	COG2911	Protein conserved in bacteria
IXO608_016420	COG0729	surface antigen
IXO608_016435	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO608_016440	COG3118	belongs to the thioredoxin family
IXO608_016450	COG2884	Cell division ATP-binding protein ftsE
IXO608_016455	COG2177	Part of the ABC transporter FtsEX involved in
IXO608_016460	COG2201	protein-glutamate methylesterase activity
IXO608_016465	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO608_016470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO608_016480	COG1252	NADH dehydrogenase
IXO608_016505	COG0459	protein refolding
IXO608_016515	COG4771	TonB-dependent receptor
IXO608_016530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO608_016570	COG3386	PFAM SMP-30 Gluconolaconase
IXO608_016585	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO608_016615	COG2353	YceI-like domain
IXO608_016710	COG0408	coproporphyrinogen oxidase activity
IXO608_016720	COG3039	Transposase
IXO608_016740	COG0129	dihydroxy-acid dehydratase activity
IXO608_016750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO608_016800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO608_016805	COG0318	PFAM AMP-dependent synthetase and ligase
IXO608_016810	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO608_016815	COG0596	Alpha beta hydrolase
IXO608_016830	COG3177	Filamentation induced by cAMP protein fic
IXO608_016835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO608_016850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO608_016875	COG4191	Histidine kinase
IXO608_016880	COG0028	Belongs to the TPP enzyme family
IXO608_016895	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO608_016900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO608_016935	COG5383	Protein conserved in bacteria
IXO608_016945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO608_016950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO608_016955	COG1473	amidohydrolase
IXO608_016965	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO608_016965	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO608_016970	COG3328	transposase activity
IXO608_016980	COG3039	Transposase
IXO608_017050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO608_017065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO608_017070	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO608_017080	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO608_017085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO608_017090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO608_017140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO608_017155	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO608_017220	COG0358	DNA primase activity
IXO608_017225	COG1295	ribonuclease BN
IXO608_017235	COG1610	YqeY-like protein
IXO608_017245	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO608_017250	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO608_017285	COG2133	pyrroloquinoline quinone binding
IXO608_017290	COG4682	membrane
IXO608_017325	COG0531	amino acid
IXO608_017360	COG4948	Mandelate Racemase Muconate Lactonizing
IXO608_017370	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO608_017375	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO608_017405	COG3039	Transposase
IXO608_017455	COG0183	Belongs to the thiolase family
IXO608_017490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IXO608_017500	COG3483	tryptophan 2,3-dioxygenase activity
IXO608_017505	COG3104	oligopeptide transport
IXO608_017525	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO608_017540	COG1320	monovalent cation:proton antiporter activity
IXO608_017545	COG2212	antiporter activity
IXO608_017555	COG0651	ATP synthesis coupled electron transport
IXO608_017560	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO608_017565	COG2111	Na H antiporter
IXO608_017565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO608_017595	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO608_017605	COG0456	acetyltransferase
IXO608_017635	COG4221	oxidoreductase activity
IXO608_017695	COG0697	spore germination
IXO608_017700	COG4305	rare lipoprotein A
IXO608_017705	COG5297	Belongs to the glycosyl hydrolase family 6
IXO608_017715	COG1113	amino acid transport
IXO608_017725	COG0598	Magnesium transport protein CorA
IXO608_017795	COG5297	Belongs to the glycosyl hydrolase family 6
IXO608_017795	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO608_017800	COG0659	secondary active sulfate transmembrane transporter activity
IXO608_017835	COG3275	phosphorelay sensor kinase activity
IXO608_017845	COG0181	hydroxymethylbilane synthase activity
IXO608_017870	COG1505	serine-type exopeptidase activity
IXO608_017885	COG0436	Aminotransferase
IXO608_017915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO608_017945	COG0308	aminopeptidase N
IXO608_017950	COG2199	diguanylate cyclase activity
IXO608_017995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO608_018000	COG1077	Cell shape determining protein MreB Mrl
IXO608_018005	COG1792	Involved in formation and maintenance of cell shape
IXO608_018020	COG0772	Belongs to the SEDS family
IXO608_018050	COG1388	LysM domain
IXO608_018050	COG3409	Peptidoglycan-binding domain 1 protein
IXO608_018050	COG5632	N-Acetylmuramoyl-L-alanine amidase
IXO608_018070	COG2951	lytic endotransglycosylase activity
IXO608_018075	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO608_018080	COG1686	Belongs to the peptidase S11 family
IXO608_018095	COG2921	Belongs to the UPF0250 family
IXO608_018135	COG1056	cytidyltransferase-related domain
IXO608_018135	COG1051	belongs to the nudix hydrolase family
IXO608_018170	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO608_018175	COG0673	inositol 2-dehydrogenase activity
IXO608_018180	COG2823	Periplasmic or secreted lipoprotein
IXO608_018185	COG4251	negative regulation of phosphorylation
IXO608_018190	COG0784	Response regulator, receiver
IXO608_018195	COG4191	Histidine kinase
IXO608_018200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO608_018250	COG3250	beta-galactosidase activity
IXO608_018265	COG2188	Transcriptional regulator
IXO608_018275	COG1609	Transcriptional regulator
IXO608_018280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO608_018285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO608_018295	COG1215	transferase activity, transferring glycosyl groups
IXO608_018300	COG0726	polysaccharide deacetylase
IXO608_018300	COG1649	PFAM Uncharacterised BCR, COG1649
IXO608_018370	COG3039	Transposase
IXO608_018380	COG3039	Transposase
IXO608_018390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO608_018395	COG3039	Transposase
IXO608_018430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO608_018450	COG2205	protein histidine kinase activity
IXO608_018485	COG2205	protein histidine kinase activity
IXO608_018535	COG0488	(ABC) transporter
IXO608_018555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO608_018575	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO608_018575	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO608_018595	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO608_018600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO608_018605	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO608_018625	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO608_018630	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO608_018640	COG2205	protein histidine kinase activity
IXO608_018645	COG0745	RESPONSE REGULATOR receiver
IXO608_018650	COG0277	FAD linked oxidase domain protein
IXO608_018655	COG1988	membrane-bound metal-dependent
IXO608_018660	COG0792	nuclease activity
IXO608_018695	COG0275	rRNA processing
IXO608_018700	COG3116	cell division
IXO608_018715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO608_018720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO608_018735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO608_018740	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO608_018745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO608_018760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO608_018770	COG1388	LysM domain
IXO608_018770	COG4942	peptidase
IXO608_018785	COG0494	nUDIX hydrolase
IXO608_018800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO608_018810	COG0604	alcohol dehydrogenase
IXO608_018810	COG3321	synthase
IXO608_018810	COG1028	Short-chain dehydrogenase reductase Sdr
IXO608_018855	COG2226	methyltransferase
IXO608_018860	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO608_018905	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO608_018920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO608_018930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO608_018935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO608_018945	COG0667	Aldo Keto reductase
IXO608_018985	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IXO608_018995	COG2175	clavaminate synthase activity
IXO608_019005	COG4181	ATPase activity
IXO608_019020	COG0642	Histidine kinase
IXO608_019045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO608_019065	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO608_019090	COG2967	ApaG domain
IXO608_019095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO608_019105	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO608_019120	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO608_019125	COG2096	Adenosyltransferase
IXO608_019135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO608_019140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO608_019180	COG0583	DNA-binding transcription factor activity
IXO608_019185	COG0318	PFAM AMP-dependent synthetase and ligase
IXO608_019195	COG1024	Enoyl-CoA hydratase
IXO608_019215	COG3386	PFAM SMP-30 Gluconolaconase
IXO608_019270	COG3039	Transposase
IXO608_019350	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO608_019350	COG1902	pentaerythritol trinitrate reductase activity
IXO608_019355	COG0604	alcohol dehydrogenase
IXO608_019380	COG0156	8-amino-7-oxononanoate synthase activity
IXO608_019385	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO608_019390	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO608_019395	COG4208	sulfate ABC transporter
IXO608_019400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO608_019430	COG0588	phosphoglycerate mutase activity
IXO608_019440	COG0285	dihydrofolate synthase activity
IXO608_019460	COG2833	Protein of unknown function (DUF455)
IXO608_019480	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO608_019485	COG0671	phosphoesterase, PA-phosphatase related
IXO608_019490	COG0438	transferase activity, transferring glycosyl groups
IXO608_019500	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO608_019515	COG4783	chaperone-mediated protein folding
IXO608_019580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO608_019585	COG0583	DNA-binding transcription factor activity
IXO608_019590	COG3634	alkyl hydroperoxide reductase activity
IXO608_019600	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO608_019650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO608_019650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO608_019665	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO608_019690	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO608_019715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO608_019725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO608_019755	COG1295	ribonuclease BN
IXO608_019760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO608_019780	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO608_019790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO608_019805	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO608_019820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO608_019830	COG0193	aminoacyl-tRNA hydrolase activity
IXO608_019835	COG0012	GTP binding
IXO608_019865	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO608_019870	COG0250	Participates in transcription elongation, termination and antitermination
IXO608_019875	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO608_019885	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO608_019890	COG0222	ribosome binding
IXO608_019895	COG0085	RNA polymerase activity
IXO608_019900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO608_019905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO608_019910	COG0049	tRNA binding
IXO608_019930	COG0051	transcription antitermination factor activity, RNA binding
IXO608_019935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO608_019940	COG0088	Forms part of the polypeptide exit tunnel
IXO608_019945	COG0089	rRNA binding
IXO608_019960	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO608_019970	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO608_019975	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO608_019980	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO608_019985	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO608_019995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO608_020025	COG1841	ribosomal large subunit assembly
IXO608_020035	COG0201	protein transport
IXO608_020045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO608_020050	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO608_020060	COG0203	ribosomal protein L17
IXO608_020120	COG3551	Protein conserved in bacteria
IXO608_020150	COG2194	sulfuric ester hydrolase activity
IXO608_020160	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO608_020165	COG0745	RESPONSE REGULATOR receiver
IXO608_020170	COG0642	Histidine kinase
IXO608_020180	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO608_020185	COG2894	cell division
IXO608_020200	COG4585	Histidine kinase
IXO608_020205	COG2197	response regulator
IXO608_020220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO608_020350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO608_020560	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO608_020580	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO608_020585	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO608_020600	COG0732	type I restriction modification DNA specificity domain
IXO608_020615	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO608_020650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO608_020655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO608_020710	COG1297	OPT oligopeptide transporter protein
IXO608_020735	COG1506	peptidase
IXO608_020735	COG0823	Involved in the tonB-independent uptake of proteins
IXO608_020765	COG2207	Transcriptional regulator
IXO608_020765	COG1917	Cupin 2, conserved barrel domain protein
IXO608_020785	COG3039	Transposase
IXO608_020805	COG0753	catalase activity
IXO608_020845	COG0469	pyruvate kinase activity
IXO608_020850	COG3588	fructose-bisphosphate aldolase
IXO608_020855	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO608_020905	COG2205	protein histidine kinase activity
IXO608_020905	COG2198	Histidine kinase
IXO608_020905	COG0784	Response regulator, receiver
IXO608_020925	COG0175	sulfate reduction
IXO608_020930	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO608_020935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO608_020940	COG0175	sulfate reduction
IXO608_020945	COG2895	sulfate adenylyltransferase (ATP) activity
IXO608_020945	COG0529	Catalyzes the synthesis of activated sulfate
IXO608_020955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO608_020960	COG0308	aminopeptidase N
IXO608_020980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO608_021005	COG1970	mechanosensitive ion channel activity
IXO608_021035	COG3273	potassium ion transport
IXO608_021035	COG0471	metal ion transport
IXO608_021045	COG2022	thiamine diphosphate biosynthetic process
IXO608_021125	COG3039	Transposase
IXO608_021130	COG3039	Transposase
IXO608_021200	COG3118	belongs to the thioredoxin family
IXO608_021225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO608_021250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO608_021275	COG2968	Membrane
IXO608_021290	COG3164	Protein of unknown function
IXO608_021300	COG0312	modulator of DNA gyrase
IXO608_021305	COG3028	Belongs to the UPF0307 family
IXO608_021310	COG0312	modulator of DNA gyrase
IXO608_021335	COG0142	geranyltranstransferase activity
IXO608_021340	COG1722	exodeoxyribonuclease VII activity
IXO608_021345	COG0037	tRNA processing
IXO608_021350	COG1785	Belongs to the alkaline phosphatase family
IXO608_021355	COG1301	dicarboxylic acid transport
IXO608_021370	COG0791	NLP P60 protein
IXO608_021375	COG0791	NLP P60 protein
IXO608_021380	COG1047	Peptidyl-prolyl cis-trans
IXO608_021385	COG2311	Membrane
IXO608_021390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO608_021430	COG0489	protein tyrosine kinase activity
IXO608_021435	COG0717	Belongs to the dCTP deaminase family
IXO608_021455	COG0412	Dienelactone hydrolase
IXO608_021465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO608_021475	COG3039	Transposase
IXO608_021510	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO608_021515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO608_021520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO608_021525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO608_021545	COG0101	tRNA pseudouridine synthase activity
IXO608_021550	COG0135	phosphoribosylanthranilate isomerase activity
IXO608_021575	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO608_021580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO608_021630	COG0149	triose-phosphate isomerase activity
IXO608_021645	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO608_021655	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO608_021660	COG0649	NAD binding
IXO608_021665	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO608_021670	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO608_021675	COG1034	ATP synthesis coupled electron transport
IXO608_021710	COG1007	ATP synthesis coupled electron transport
IXO608_021720	COG0779	Required for maturation of 30S ribosomal subunits
IXO608_021725	COG0195	Participates in both transcription termination and antitermination
IXO608_021745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO608_021750	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO608_021785	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO608_021795	COG2095	MarC family integral membrane protein
IXO608_021810	COG1611	Belongs to the LOG family
IXO608_021850	COG4969	Belongs to the N-Me-Phe pilin family
IXO608_021890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO608_021960	COG0438	transferase activity, transferring glycosyl groups
IXO608_021965	COG0438	transferase activity, transferring glycosyl groups
IXO608_021975	COG0438	transferase activity, transferring glycosyl groups
IXO608_022015	COG3040	lipid binding
IXO608_022105	COG4191	Histidine kinase
IXO608_022105	COG0784	Response regulator, receiver
IXO608_022125	COG0552	protein localization to endoplasmic reticulum
IXO608_022135	COG3938	Belongs to the proline racemase family
IXO608_022140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO608_022155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO608_022165	COG0006	proline dipeptidase activity
IXO608_022180	COG0531	amino acid
IXO608_022255	COG4206	TonB-dependent receptor
IXO608_022260	COG3328	transposase activity
IXO608_022325	COG0746	molybdenum cofactor guanylyltransferase activity
IXO608_022350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO608_022350	COG1648	precorrin-2 dehydrogenase activity
IXO608_022390	COG3039	Transposase
IXO608_022395	COG3039	Transposase
IXO608_022435	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO608_022455	COG3039	Transposase
IXO608_022460	COG1054	Belongs to the UPF0176 family
IXO608_022475	COG1530	ribonuclease E activity
IXO608_022485	COG3064	Membrane
IXO608_022490	COG0428	transporter
IXO608_022495	COG0428	transporter
IXO608_022505	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO608_022510	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IXO608_022510	COG0316	Belongs to the HesB IscA family
IXO608_022555	COG3039	Transposase
IXO608_022665	COG0631	protein serine/threonine phosphatase activity
IXO608_022670	COG0515	serine threonine protein kinase
IXO608_022705	COG1858	cytochrome C peroxidase
IXO608_022755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO608_022760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family