locus-tag	class	description
IXO639_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO639_000020	COG0187	DNA topoisomerase II activity
IXO639_000030	COG0501	Belongs to the peptidase M48B family
IXO639_000060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO639_000070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO639_000085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO639_000095	COG4772	TonB-dependent receptor
IXO639_000110	COG3039	Transposase
IXO639_000115	COG1304	FMN binding
IXO639_000135	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO639_000145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO639_000230	COG2826	transposase and inactivated derivatives, IS30 family
IXO639_000255	COG3039	Transposase
IXO639_000265	COG1090	epimerase
IXO639_000275	COG0642	Histidine kinase
IXO639_000285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO639_000395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO639_000470	COG1511	domain protein
IXO639_000470	COG3264	Mechanosensitive ion channel
IXO639_000485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO639_000490	COG2354	Protein conserved in bacteria
IXO639_000495	COG1649	PFAM Uncharacterised BCR, COG1649
IXO639_000515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO639_000540	COG0702	epimerase
IXO639_000555	COG1858	cytochrome C peroxidase
IXO639_000630	COG0513	Belongs to the DEAD box helicase family
IXO639_000635	COG3039	Transposase
IXO639_000680	COG1136	(ABC) transporter
IXO639_000720	COG1136	(ABC) transporter
IXO639_000760	COG1272	protein, Hemolysin III
IXO639_000765	COG1111	helicase
IXO639_000765	COG1205	dead DEAH box helicase
IXO639_000825	COG0069	glutamate synthase activity
IXO639_000825	COG0067	glutamate synthase
IXO639_000825	COG0070	glutamate synthase
IXO639_000830	COG0493	'glutamate synthase
IXO639_000880	COG1609	Transcriptional regulator
IXO639_000910	COG0366	Alpha amylase catalytic
IXO639_000915	COG0366	Alpha amylase catalytic
IXO639_000960	COG0606	chelatase, subunit chli
IXO639_001000	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO639_001005	COG1166	arginine decarboxylase activity
IXO639_001070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO639_001095	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_001120	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO639_001135	COG0210	DNA helicase
IXO639_001150	COG3132	Protein of unknown function, DUF480
IXO639_001155	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO639_001160	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO639_001195	COG2937	Belongs to the GPAT DAPAT family
IXO639_001235	COG3186	Phenylalanine-4-hydroxylase
IXO639_001240	COG1522	sequence-specific DNA binding
IXO639_001285	COG1064	alcohol dehydrogenase
IXO639_001290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO639_001300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO639_001310	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO639_001330	COG0676	glucose-6-phosphate 1-epimerase activity
IXO639_001395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO639_001420	COG2853	Lipoprotein
IXO639_001435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO639_001440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO639_001445	COG1127	ABC transporter
IXO639_001520	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO639_001530	COG3039	Transposase
IXO639_001535	COG3265	gluconokinase activity
IXO639_001540	COG2211	Major facilitator Superfamily
IXO639_001545	COG3459	Glycosyltransferase 36 associated
IXO639_001555	COG2205	protein histidine kinase activity
IXO639_001565	COG1414	Transcriptional regulator
IXO639_001570	COG0738	Major facilitator superfamily
IXO639_001575	COG3254	rhamnose metabolic process
IXO639_001605	COG0339	signal peptide processing
IXO639_001635	COG0564	pseudouridine synthase activity
IXO639_001645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO639_001655	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO639_001720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO639_001730	COG0842	Transport permease protein
IXO639_001735	COG1131	(ABC) transporter
IXO639_001765	COG1476	TRANSCRIPTIONal
IXO639_001775	COG4555	ABC transporter
IXO639_001810	COG0625	glutathione transferase activity
IXO639_001855	COG0583	DNA-binding transcription factor activity
IXO639_001895	COG1199	ATP-dependent helicase activity
IXO639_001915	COG1566	PFAM secretion protein HlyD family protein
IXO639_001935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO639_001975	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO639_001975	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO639_001980	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO639_001995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO639_002030	COG3237	CsbD-like
IXO639_002035	COG0180	Tryptophanyl-tRNA synthetase
IXO639_002040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO639_002085	COG0753	catalase activity
IXO639_002100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO639_002110	COG0628	permease
IXO639_002120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO639_002125	COG1040	competence protein
IXO639_002130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO639_002135	COG0156	8-amino-7-oxononanoate synthase activity
IXO639_002145	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_002160	COG0463	Glycosyl transferase, family 2
IXO639_002170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO639_002175	COG3100	YcgL domain-containing protein
IXO639_002190	COG3387	PFAM Glycoside hydrolase 15-related
IXO639_002195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO639_002210	COG2239	Acts as a magnesium transporter
IXO639_002225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO639_002225	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO639_002225	COG1042	CoA-binding domain protein
IXO639_002235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO639_002240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO639_002280	COG3485	protocatechuate 3,4-dioxygenase
IXO639_002300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO639_002305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO639_002330	COG4221	oxidoreductase activity
IXO639_002355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO639_002380	COG0463	Glycosyl transferase, family 2
IXO639_002395	COG1475	DNA binding
IXO639_002400	COG1192	Involved in chromosome partitioning
IXO639_002415	COG0708	Exodeoxyribonuclease III
IXO639_002420	COG2211	Major facilitator Superfamily
IXO639_002435	COG0739	heme binding
IXO639_002480	COG0745	RESPONSE REGULATOR receiver
IXO639_002520	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO639_002535	COG2814	Major facilitator Superfamily
IXO639_002550	COG1289	transmembrane transporter activity
IXO639_002575	COG0151	Belongs to the GarS family
IXO639_002585	COG0138	bifunctional purine biosynthesis protein purh
IXO639_002600	COG3039	Transposase
IXO639_002605	COG2267	carboxylic ester hydrolase activity
IXO639_002610	COG2267	carboxylic ester hydrolase activity
IXO639_002630	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO639_002675	COG0439	Biotin carboxylase
IXO639_002685	COG0511	ligase activity, forming carbon-carbon bonds
IXO639_002690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO639_002700	COG1324	tolerance protein
IXO639_002735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO639_002760	COG0534	Mate efflux family protein
IXO639_002765	COG0616	signal peptide processing
IXO639_002775	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_002790	COG0009	L-threonylcarbamoyladenylate synthase
IXO639_002795	COG1754	DNA topoisomerase type I activity
IXO639_002795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO639_002810	COG2922	Belongs to the Smg family
IXO639_002815	COG0758	DNA mediated transformation
IXO639_002820	COG1652	LysM domain
IXO639_002825	COG0242	peptide deformylase activity
IXO639_002830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO639_002835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO639_002835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO639_002885	COG1560	Kdo2-lipid A biosynthetic process
IXO639_002895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO639_003040	COG3039	Transposase
IXO639_003050	COG1271	oxidase subunit
IXO639_003105	COG2972	Histidine kinase
IXO639_003120	COG0531	amino acid
IXO639_003140	COG3590	peptidase
IXO639_003150	COG0667	Aldo Keto reductase
IXO639_003165	COG3384	dioxygenase
IXO639_003175	COG1573	uracil-dna glycosylase
IXO639_003185	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO639_003195	COG0025	NhaP-type Na H and K H
IXO639_003200	COG1131	(ABC) transporter
IXO639_003205	COG0842	Transport permease protein
IXO639_003220	COG1404	Belongs to the peptidase S8 family
IXO639_003235	COG0745	RESPONSE REGULATOR receiver
IXO639_003285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO639_003310	COG2202	Pas domain
IXO639_003310	COG2205	protein histidine kinase activity
IXO639_003340	COG2813	Specifically methylates the guanine in position
IXO639_003345	COG1187	pseudouridine synthase activity
IXO639_003350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO639_003385	COG0697	spore germination
IXO639_003395	COG2011	ABC-type metal ion transport system permease component
IXO639_003425	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO639_003435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO639_003455	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO639_003465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO639_003475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO639_003480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO639_003485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO639_003490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXO639_003540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO639_003545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO639_003595	COG0339	signal peptide processing
IXO639_003630	COG1956	GAF domain-containing protein
IXO639_003635	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO639_003645	COG0720	synthase
IXO639_003650	COG0513	Belongs to the DEAD box helicase family
IXO639_003660	COG0625	glutathione transferase activity
IXO639_003690	COG0626	cystathionine gamma-synthase activity
IXO639_003730	COG3328	transposase activity
IXO639_003755	COG2086	electron transfer activity
IXO639_003780	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO639_003780	COG0662	Cupin 2, conserved barrel domain protein
IXO639_003785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO639_003820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO639_003820	COG3218	ABC-type transport auxiliary lipoprotein component
IXO639_003825	COG1127	ABC transporter
IXO639_003830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO639_003850	COG0442	prolyl-tRNA aminoacylation
IXO639_003860	COG1183	phosphatidylcholine synthase activity
IXO639_003890	COG3039	Transposase
IXO639_003925	COG3039	Transposase
IXO639_003955	COG0525	valine-tRNA ligase activity
IXO639_003970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO639_003980	COG0795	lipopolysaccharide-transporting ATPase activity
IXO639_003995	COG4974	Belongs to the 'phage' integrase family
IXO639_004000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO639_004005	COG0047	phosphoribosylformylglycinamidine synthase activity
IXO639_004005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXO639_004010	COG5295	Hep Hag repeat protein
IXO639_004020	COG1404	Belongs to the peptidase S8 family
IXO639_004030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO639_004040	COG1459	type II secretion system
IXO639_004045	COG2165	general secretion pathway protein
IXO639_004050	COG4970	Tfp pilus assembly protein FimT
IXO639_004055	COG2165	general secretion pathway protein
IXO639_004060	COG4795	General secretion pathway protein
IXO639_004065	COG3156	type II secretion system protein K
IXO639_004070	COG3166	PFAM Fimbrial assembly family protein
IXO639_004085	COG1450	Type ii and iii secretion system protein
IXO639_004100	COG2188	Transcriptional regulator
IXO639_004150	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO639_004155	COG1518	maintenance of DNA repeat elements
IXO639_004190	COG3039	Transposase
IXO639_004205	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO639_004230	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_004235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO639_004245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO639_004250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO639_004280	COG3829	transcription factor binding
IXO639_004355	COG2826	transposase and inactivated derivatives, IS30 family
IXO639_004365	COG0678	peroxiredoxin activity
IXO639_004385	COG0330	HflC and HflK could
IXO639_004390	COG0330	HflC and HflK could
IXO639_004400	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO639_004405	COG0308	aminopeptidase N
IXO639_004465	COG1560	Kdo2-lipid A biosynthetic process
IXO639_004470	COG1519	Transferase
IXO639_004475	COG1538	Outer membrane efflux protein
IXO639_004480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO639_004510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO639_004515	COG0066	3-isopropylmalate dehydratase activity
IXO639_004520	COG2226	methyltransferase
IXO639_004550	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO639_004560	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO639_004565	COG3710	Transcriptional regulator
IXO639_004590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO639_004610	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO639_004645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO639_004655	COG3781	membrane
IXO639_004790	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO639_004810	COG1217	gtp-binding protein TYPA
IXO639_004815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO639_004820	COG0039	L-malate dehydrogenase activity
IXO639_004825	COG0625	glutathione transferase activity
IXO639_004840	COG3039	Transposase
IXO639_004865	COG0584	glycerophosphoryl diester phosphodiesterase
IXO639_004900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO639_004935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO639_004940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO639_004945	COG0583	DNA-binding transcription factor activity
IXO639_004950	COG3634	alkyl hydroperoxide reductase activity
IXO639_004960	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO639_005005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO639_005005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO639_005020	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO639_005045	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO639_005070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO639_005080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO639_005110	COG1295	ribonuclease BN
IXO639_005115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO639_005135	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO639_005145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO639_005150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO639_005160	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO639_005175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO639_005185	COG0193	aminoacyl-tRNA hydrolase activity
IXO639_005190	COG0012	GTP binding
IXO639_005220	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO639_005225	COG0250	Participates in transcription elongation, termination and antitermination
IXO639_005230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO639_005240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO639_005245	COG0222	ribosome binding
IXO639_005250	COG0085	RNA polymerase activity
IXO639_005255	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO639_005260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO639_005265	COG0049	tRNA binding
IXO639_005285	COG0051	transcription antitermination factor activity, RNA binding
IXO639_005290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO639_005295	COG0088	Forms part of the polypeptide exit tunnel
IXO639_005300	COG0089	rRNA binding
IXO639_005315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO639_005325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO639_005330	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO639_005335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO639_005340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO639_005350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO639_005380	COG1841	ribosomal large subunit assembly
IXO639_005390	COG0201	protein transport
IXO639_005400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO639_005405	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO639_005415	COG0203	ribosomal protein L17
IXO639_005475	COG3551	Protein conserved in bacteria
IXO639_005505	COG2194	sulfuric ester hydrolase activity
IXO639_005515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO639_005520	COG0745	RESPONSE REGULATOR receiver
IXO639_005525	COG0642	Histidine kinase
IXO639_005535	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO639_005540	COG2894	cell division
IXO639_005555	COG4585	Histidine kinase
IXO639_005560	COG2197	response regulator
IXO639_005575	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO639_005600	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IXO639_005605	COG2963	transposase activity
IXO639_005710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO639_005725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO639_005735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO639_005780	COG3328	transposase activity
IXO639_005795	COG3179	chitinase
IXO639_005910	COG3039	Transposase
IXO639_005925	COG3039	Transposase
IXO639_005985	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO639_006005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO639_006010	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO639_006015	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO639_006030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO639_006065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO639_006070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO639_006105	COG0587	DNA-directed DNA polymerase activity
IXO639_006120	COG1297	OPT oligopeptide transporter protein
IXO639_006140	COG1506	peptidase
IXO639_006140	COG0823	Involved in the tonB-independent uptake of proteins
IXO639_006160	COG1917	Cupin 2, conserved barrel domain protein
IXO639_006160	COG2207	Transcriptional regulator
IXO639_006185	COG0753	catalase activity
IXO639_006215	COG0126	phosphoglycerate kinase activity
IXO639_006225	COG0469	pyruvate kinase activity
IXO639_006230	COG3588	fructose-bisphosphate aldolase
IXO639_006235	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO639_006280	COG0784	Response regulator, receiver
IXO639_006280	COG2198	Histidine kinase
IXO639_006280	COG2205	protein histidine kinase activity
IXO639_006300	COG0175	sulfate reduction
IXO639_006305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO639_006310	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO639_006315	COG0175	sulfate reduction
IXO639_006320	COG2895	sulfate adenylyltransferase (ATP) activity
IXO639_006320	COG0529	Catalyzes the synthesis of activated sulfate
IXO639_006330	COG3039	Transposase
IXO639_006340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO639_006345	COG0308	aminopeptidase N
IXO639_006365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO639_006385	COG1970	mechanosensitive ion channel activity
IXO639_006415	COG0471	metal ion transport
IXO639_006415	COG3273	potassium ion transport
IXO639_006425	COG2022	thiamine diphosphate biosynthetic process
IXO639_006485	COG3039	Transposase
IXO639_006550	COG3118	belongs to the thioredoxin family
IXO639_006575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO639_006600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO639_006630	COG2968	Membrane
IXO639_006645	COG3164	Protein of unknown function
IXO639_006655	COG0312	modulator of DNA gyrase
IXO639_006660	COG3028	Belongs to the UPF0307 family
IXO639_006665	COG0312	modulator of DNA gyrase
IXO639_006690	COG0142	geranyltranstransferase activity
IXO639_006695	COG1722	exodeoxyribonuclease VII activity
IXO639_006700	COG0037	tRNA processing
IXO639_006705	COG1785	Belongs to the alkaline phosphatase family
IXO639_006710	COG1301	dicarboxylic acid transport
IXO639_006730	COG0791	NLP P60 protein
IXO639_006735	COG0791	NLP P60 protein
IXO639_006740	COG1047	Peptidyl-prolyl cis-trans
IXO639_006745	COG2311	Membrane
IXO639_006750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO639_006790	COG0489	protein tyrosine kinase activity
IXO639_006795	COG0717	Belongs to the dCTP deaminase family
IXO639_006815	COG0412	Dienelactone hydrolase
IXO639_006825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO639_006865	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO639_006870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO639_006875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO639_006880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO639_006900	COG0101	tRNA pseudouridine synthase activity
IXO639_006905	COG0135	phosphoribosylanthranilate isomerase activity
IXO639_006925	COG0159	tryptophan synthase activity
IXO639_006930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO639_006935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO639_006985	COG0149	triose-phosphate isomerase activity
IXO639_007000	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO639_007010	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO639_007015	COG0649	NAD binding
IXO639_007020	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO639_007025	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO639_007030	COG1034	ATP synthesis coupled electron transport
IXO639_007035	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO639_007065	COG1007	ATP synthesis coupled electron transport
IXO639_007075	COG0779	Required for maturation of 30S ribosomal subunits
IXO639_007080	COG0195	Participates in both transcription termination and antitermination
IXO639_007085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IXO639_007100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO639_007105	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO639_007140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO639_007150	COG2095	MarC family integral membrane protein
IXO639_007165	COG1611	Belongs to the LOG family
IXO639_007205	COG4969	Belongs to the N-Me-Phe pilin family
IXO639_007210	COG0556	nucleotide-excision repair
IXO639_007250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO639_007265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO639_007320	COG0438	transferase activity, transferring glycosyl groups
IXO639_007325	COG0438	transferase activity, transferring glycosyl groups
IXO639_007335	COG0438	transferase activity, transferring glycosyl groups
IXO639_007375	COG3040	lipid binding
IXO639_007455	COG3039	Transposase
IXO639_007460	COG0784	Response regulator, receiver
IXO639_007460	COG4191	Histidine kinase
IXO639_007480	COG0552	protein localization to endoplasmic reticulum
IXO639_007490	COG3938	Belongs to the proline racemase family
IXO639_007495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO639_007510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO639_007520	COG0006	proline dipeptidase activity
IXO639_007535	COG0531	amino acid
IXO639_007585	COG4206	TonB-dependent receptor
IXO639_007610	COG3328	transposase activity
IXO639_007670	COG0746	molybdenum cofactor guanylyltransferase activity
IXO639_007695	COG1648	precorrin-2 dehydrogenase activity
IXO639_007695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO639_007735	COG3039	Transposase
IXO639_007740	COG3039	Transposase
IXO639_007775	COG3039	Transposase
IXO639_007790	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO639_007810	COG1054	Belongs to the UPF0176 family
IXO639_007825	COG1530	ribonuclease E activity
IXO639_007835	COG3064	Membrane
IXO639_007840	COG0428	transporter
IXO639_007845	COG0428	transporter
IXO639_007855	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO639_007905	COG3039	Transposase
IXO639_008025	COG0631	protein serine/threonine phosphatase activity
IXO639_008030	COG0515	serine threonine protein kinase
IXO639_008060	COG1858	cytochrome C peroxidase
IXO639_008110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO639_008115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO639_008135	COG2201	protein-glutamate methylesterase activity
IXO639_008180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO639_008200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO639_008215	COG1595	DNA-templated transcription, initiation
IXO639_008265	COG2244	polysaccharide biosynthetic process
IXO639_008295	COG2264	protein methyltransferase activity
IXO639_008305	COG0438	transferase activity, transferring glycosyl groups
IXO639_008320	COG1136	(ABC) transporter
IXO639_008325	COG1132	(ABC) transporter
IXO639_008335	COG0477	Major facilitator Superfamily
IXO639_008345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO639_008360	COG1253	flavin adenine dinucleotide binding
IXO639_008370	COG0306	phosphate transporter
IXO639_008400	COG0504	CTP synthase activity
IXO639_008405	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO639_008415	COG0148	phosphopyruvate hydratase activity
IXO639_008420	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO639_008425	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO639_008435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO639_008445	COG2840	Smr protein MutS2
IXO639_008450	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO639_008455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO639_008460	COG1238	metal cluster binding
IXO639_008475	COG1534	Rna-binding protein
IXO639_008480	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO639_008490	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO639_008505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO639_008510	COG1546	Belongs to the CinA family
IXO639_008525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO639_008530	COG2137	regulation of response to DNA damage stimulus
IXO639_008535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO639_008540	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO639_008565	COG0305	Participates in initiation and elongation during chromosome replication
IXO639_008570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO639_008595	COG1741	Belongs to the pirin family
IXO639_008600	COG0583	DNA-binding transcription factor activity
IXO639_008630	COG0351	phosphomethylpyrimidine kinase
IXO639_008640	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO639_008645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO639_008665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO639_008675	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO639_008680	COG3734	2-keto-3-deoxy-galactonokinase
IXO639_008690	COG4948	Mandelate Racemase Muconate Lactonizing
IXO639_008695	COG0800	Aldolase
IXO639_008710	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO639_008720	COG1070	Carbohydrate kinase
IXO639_008730	COG0477	Major facilitator Superfamily
IXO639_008750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO639_008800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO639_008805	COG2258	MOSC domain
IXO639_008815	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO639_008820	COG0505	Belongs to the CarA family
IXO639_008830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO639_008835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO639_008845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO639_008910	COG0784	Response regulator, receiver
IXO639_008910	COG2198	Histidine kinase
IXO639_008910	COG2205	protein histidine kinase activity
IXO639_008915	COG1024	Enoyl-CoA hydratase
IXO639_008920	COG0318	PFAM AMP-dependent synthetase and ligase
IXO639_008950	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO639_008980	COG0840	transmembrane signaling receptor activity
IXO639_009000	COG3039	Transposase
IXO639_009015	COG0835	chemotaxis
IXO639_009030	COG0840	transmembrane signaling receptor activity
IXO639_009035	COG0840	transmembrane signaling receptor activity
IXO639_009040	COG0840	transmembrane signaling receptor activity
IXO639_009045	COG0840	transmembrane signaling receptor activity
IXO639_009055	COG0840	transmembrane signaling receptor activity
IXO639_009065	COG0840	transmembrane signaling receptor activity
IXO639_009075	COG0840	transmembrane signaling receptor activity
IXO639_009095	COG0745	RESPONSE REGULATOR receiver
IXO639_009105	COG0835	chemotaxis
IXO639_009115	COG1360	Flagellar Motor Protein
IXO639_009120	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO639_009140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO639_009150	COG4771	TonB-dependent receptor
IXO639_009185	COG3039	Transposase
IXO639_009325	COG3039	Transposase
IXO639_009340	COG3039	Transposase
IXO639_009350	COG3039	Transposase
IXO639_009365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO639_009365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO639_009370	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO639_009375	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO639_009375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO639_009380	COG1609	Transcriptional regulator
IXO639_009405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO639_009410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO639_009420	COG2902	Dehydrogenase
IXO639_009425	COG3039	Transposase
IXO639_009435	COG2205	protein histidine kinase activity
IXO639_009435	COG5002	protein histidine kinase activity
IXO639_009435	COG0784	Response regulator, receiver
IXO639_009440	COG2733	membrane
IXO639_009450	COG1121	(ABC) transporter
IXO639_009455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO639_009465	COG2223	nitrite transmembrane transporter activity
IXO639_009475	COG0243	molybdopterin cofactor binding
IXO639_009485	COG0477	Major facilitator Superfamily
IXO639_009495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO639_009500	COG0174	glutamine synthetase
IXO639_009505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO639_009535	COG3842	ATPase activity
IXO639_009545	COG1177	transmembrane transport
IXO639_009555	COG1012	belongs to the aldehyde dehydrogenase family
IXO639_009570	COG4535	Mg2 and Co2 transporter CorC
IXO639_009590	COG1702	phosphate starvation-inducible protein PhoH
IXO639_009615	COG0741	lytic transglycosylase activity
IXO639_009620	COG0723	plastoquinol--plastocyanin reductase activity
IXO639_009625	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO639_009630	COG2857	Cytochrome c1
IXO639_009635	COG0625	glutathione transferase activity
IXO639_009640	COG2969	positive regulation of protein catabolic process
IXO639_009675	COG3328	transposase activity
IXO639_009750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO639_009770	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO639_009775	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO639_009775	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO639_009780	COG0802	atpase or kinase
IXO639_009785	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO639_009790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO639_009810	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_009820	COG0501	Belongs to the peptidase M48B family
IXO639_009830	COG2081	HI0933 family
IXO639_009835	COG4681	YaeQ
IXO639_009840	COG1671	Belongs to the UPF0178 family
IXO639_009850	COG0625	glutathione transferase activity
IXO639_009860	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IXO639_009865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO639_009870	COG0513	Belongs to the DEAD box helicase family
IXO639_009875	COG0488	(ABC) transporter
IXO639_009895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO639_009900	COG0483	inositol monophosphate 1-phosphatase activity
IXO639_009915	COG5001	Diguanylate cyclase
IXO639_009915	COG3300	MHYT domain
IXO639_009920	COG1509	lysine 2,3-aminomutase activity
IXO639_009935	COG0402	S-adenosylhomocysteine deaminase activity
IXO639_009940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO639_009965	COG4677	pectinesterase activity
IXO639_009990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO639_010015	COG2166	iron-sulfur cluster assembly
IXO639_010030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO639_010035	COG0137	argininosuccinate synthase activity
IXO639_010045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO639_010050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO639_010065	COG0165	Argininosuccinate lyase
IXO639_010085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO639_010120	COG3039	Transposase
IXO639_010135	COG4988	ABC transporter
IXO639_010140	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO639_010150	COG3039	Transposase
IXO639_010250	COG3039	Transposase
IXO639_010265	COG3209	COG3209 Rhs family protein
IXO639_010275	COG3039	Transposase
IXO639_010310	COG0643	Histidine kinase
IXO639_010310	COG0784	Response regulator, receiver
IXO639_010310	COG2198	Histidine kinase
IXO639_010365	COG1684	flagellar biosynthetic protein fliR
IXO639_010380	COG3190	flagellar
IXO639_010430	COG1677	Flagellar hook-basal body complex protein FliE
IXO639_010460	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_010470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO639_010490	COG2201	protein-glutamate methylesterase activity
IXO639_010520	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO639_010525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO639_010560	COG4787	bacterial-type flagellum-dependent cell motility
IXO639_010570	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO639_010575	COG1558	bacterial-type flagellum-dependent cell motility
IXO639_010585	COG0835	chemotaxis
IXO639_010585	COG0784	Response regulator, receiver
IXO639_010605	COG5002	protein histidine kinase activity
IXO639_010615	COG4585	Histidine kinase
IXO639_010620	COG5001	Diguanylate cyclase
IXO639_010645	COG0482	sulfurtransferase activity
IXO639_010660	COG0542	response to heat
IXO639_010685	COG0492	ferredoxin-NADP+ reductase activity
IXO639_010690	COG1674	ftsk spoiiie
IXO639_010710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO639_010730	COG0038	chloride channel
IXO639_010735	COG0183	Belongs to the thiolase family
IXO639_010740	COG1024	Enoyl-CoA hydratase
IXO639_010740	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO639_010755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO639_010765	COG1426	Protein conserved in bacteria
IXO639_010775	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO639_010785	COG0303	'Molybdopterin
IXO639_010840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO639_010890	COG0742	ribosomal rna small subunit methyltransferase
IXO639_010895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO639_010910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO639_010915	COG0405	Gamma-glutamyltransferase
IXO639_010940	COG3039	Transposase
IXO639_011025	COG0343	queuine tRNA-ribosyltransferase activity
IXO639_011030	COG1862	Preprotein translocase
IXO639_011035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO639_011040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO639_011080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO639_011090	COG0704	Plays a role in the regulation of phosphate uptake
IXO639_011105	COG0573	inorganic phosphate transmembrane transporter activity
IXO639_011110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO639_011155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO639_011165	COG1024	Enoyl-CoA hydratase
IXO639_011180	COG0494	nUDIX hydrolase
IXO639_011225	COG0116	Belongs to the methyltransferase superfamily
IXO639_011225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO639_011250	COG0667	Aldo Keto reductase
IXO639_011260	COG2925	Exonuclease
IXO639_011295	COG0288	reversible hydration of carbon dioxide
IXO639_011325	COG0316	Belongs to the HesB IscA family
IXO639_011330	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO639_011340	COG0359	binds to the 23S rRNA
IXO639_011350	COG3115	cell septum assembly
IXO639_011370	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO639_011390	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO639_011415	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO639_011425	COG2986	histidine ammonia-lyase
IXO639_011430	COG1228	amidohydrolase
IXO639_011470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO639_011480	COG0077	Prephenate dehydratase
IXO639_011480	COG1605	Chorismate mutase
IXO639_011485	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO639_011520	COG4566	intracellular signal transduction
IXO639_011565	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO639_011570	COG1469	GTP cyclohydrolase I activity
IXO639_011580	COG0617	tRNA 3'-terminal CCA addition
IXO639_011590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO639_011595	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO639_011625	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO639_011640	COG2203	Gaf domain
IXO639_011640	COG3706	GGDEF domain
IXO639_011640	COG4251	negative regulation of phosphorylation
IXO639_011640	COG5001	Diguanylate cyclase
IXO639_011700	COG1595	DNA-templated transcription, initiation
IXO639_011725	COG0386	Belongs to the glutathione peroxidase family
IXO639_011805	COG3039	Transposase
IXO639_011820	COG5002	protein histidine kinase activity
IXO639_011820	COG0784	Response regulator, receiver
IXO639_011820	COG2205	protein histidine kinase activity
IXO639_011860	COG0800	Aldolase
IXO639_011865	COG0129	dihydroxy-acid dehydratase activity
IXO639_011870	COG0363	glucosamine-6-phosphate deaminase activity
IXO639_011880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO639_011895	COG0354	folic acid binding
IXO639_011910	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO639_011925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO639_011940	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO639_011965	COG0811	peptide transport
IXO639_011980	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO639_011990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO639_012000	COG0322	excinuclease ABC activity
IXO639_012035	COG3328	transposase activity
IXO639_012055	COG3039	Transposase
IXO639_012070	COG2801	Transposase and inactivated derivatives
IXO639_012080	COG2201	protein-glutamate methylesterase activity
IXO639_012130	COG0653	protein targeting
IXO639_012220	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO639_012220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO639_012230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO639_012240	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO639_012240	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO639_012255	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO639_012275	COG0124	histidyl-tRNA synthetase
IXO639_012290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO639_012325	COG1012	belongs to the aldehyde dehydrogenase family
IXO639_012350	COG0697	spore germination
IXO639_012355	COG1794	racemase activity, acting on amino acids and derivatives
IXO639_012375	COG0671	phosphoesterase, PA-phosphatase related
IXO639_012390	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO639_012405	COG2183	response to ionizing radiation
IXO639_012415	COG0723	plastoquinol--plastocyanin reductase activity
IXO639_012415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO639_012430	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO639_012440	COG1183	phosphatidylcholine synthase activity
IXO639_012445	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_012470	COG0668	transmembrane transport
IXO639_012490	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO639_012540	COG0583	DNA-binding transcription factor activity
IXO639_012545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO639_012550	COG3002	Belongs to the UPF0753 family
IXO639_012565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO639_012585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO639_012595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO639_012600	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO639_012610	COG0776	regulation of translation
IXO639_012615	COG0539	negative regulation of cytoplasmic translation
IXO639_012620	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO639_012635	COG2957	Belongs to the agmatine deiminase family
IXO639_012645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO639_012670	COG0395	ABC-type sugar transport system, permease component
IXO639_012675	COG1175	transmembrane transport
IXO639_012705	COG2350	Protein conserved in bacteria
IXO639_012710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO639_012715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO639_012720	COG1187	pseudouridine synthase activity
IXO639_012745	COG0436	Aminotransferase
IXO639_012810	COG0277	FAD linked oxidase domain protein
IXO639_012815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO639_012825	COG0531	amino acid
IXO639_012830	COG0531	amino acid
IXO639_012835	COG0235	Class ii aldolase
IXO639_012840	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO639_012870	COG2201	protein-glutamate methylesterase activity
IXO639_012915	COG0583	DNA-binding transcription factor activity
IXO639_012925	COG3039	Transposase
IXO639_013030	COG3039	Transposase
IXO639_013040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO639_013060	COG0557	exoribonuclease II activity
IXO639_013085	COG1960	acyl-CoA dehydrogenase activity
IXO639_013090	COG2226	methyltransferase
IXO639_013095	COG0646	methionine synthase
IXO639_013095	COG1410	methionine synthase
IXO639_013100	COG0646	methionine synthase
IXO639_013100	COG1410	methionine synthase
IXO639_013110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO639_013120	COG1609	Transcriptional regulator
IXO639_013135	COG2900	Belongs to the SlyX family
IXO639_013150	COG0386	Belongs to the glutathione peroxidase family
IXO639_013160	COG1725	Transcriptional regulator
IXO639_013165	COG1131	(ABC) transporter
IXO639_013230	COG2850	peptidyl-arginine hydroxylation
IXO639_013265	COG1132	(ABC) transporter
IXO639_013280	COG0583	DNA-binding transcription factor activity
IXO639_013295	COG1605	Chorismate mutase
IXO639_013295	COG0287	Prephenate dehydrogenase
IXO639_013300	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO639_013305	COG0484	heat shock protein binding
IXO639_013310	COG0443	Heat shock 70 kDa protein
IXO639_013315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO639_013325	COG0497	DNA recombination
IXO639_013335	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO639_013340	COG2914	Belongs to the UPF0125 (RnfH) family
IXO639_013350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO639_013365	COG1960	acyl-CoA dehydrogenase activity
IXO639_013375	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO639_013430	COG2814	Major facilitator Superfamily
IXO639_013435	COG1566	PFAM secretion protein HlyD family protein
IXO639_013450	COG2207	Transcriptional regulator
IXO639_013475	COG4774	siderophore transport
IXO639_013485	COG0367	asparagine synthase
IXO639_013500	COG1393	Belongs to the ArsC family
IXO639_013515	COG3039	Transposase
IXO639_013565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO639_013580	COG0233	cytoplasmic translational termination
IXO639_013590	COG0575	Belongs to the CDS family
IXO639_013600	COG0750	zinc metalloprotease
IXO639_013615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO639_013620	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO639_013640	COG0825	malonyl-CoA metabolic process
IXO639_013650	COG4771	TonB-dependent receptor
IXO639_013655	COG1131	(ABC) transporter
IXO639_013680	COG1981	membrane
IXO639_013725	COG2895	sulfate adenylyltransferase (ATP) activity
IXO639_013725	COG0529	Catalyzes the synthesis of activated sulfate
IXO639_013760	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO639_013775	COG2040	homocysteine
IXO639_013780	COG0833	amino acid
IXO639_013800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO639_013800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO639_013810	COG2878	Part of a membrane complex involved in electron transport
IXO639_013825	COG1595	DNA-templated transcription, initiation
IXO639_013850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO639_013865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO639_013870	COG0251	oxidation-reduction process
IXO639_013880	COG0392	lysyltransferase activity
IXO639_013880	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO639_013910	COG3039	Transposase
IXO639_013925	COG2814	Major facilitator Superfamily
IXO639_013930	COG1902	pentaerythritol trinitrate reductase activity
IXO639_013940	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO639_013955	COG1047	Peptidyl-prolyl cis-trans
IXO639_013995	COG3039	Transposase
IXO639_014005	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO639_014020	COG1451	nucleotide metabolic process
IXO639_014040	COG0183	Belongs to the thiolase family
IXO639_014070	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO639_014070	COG1793	dna ligase
IXO639_014080	COG1793	dna ligase
IXO639_014085	COG1201	RNA secondary structure unwinding
IXO639_014105	COG1278	Cold shock
IXO639_014110	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO639_014115	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO639_014125	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO639_014135	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO639_014160	COG3039	Transposase
IXO639_014170	COG2954	triphosphatase activity
IXO639_014185	COG1381	Involved in DNA repair and RecF pathway recombination
IXO639_014215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO639_014230	COG1024	Enoyl-CoA hydratase
IXO639_014230	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO639_014250	COG1024	Enoyl-CoA hydratase
IXO639_014255	COG1960	acyl-CoA dehydrogenase activity
IXO639_014325	COG2353	YceI-like domain
IXO639_014335	COG2353	YceI-like domain
IXO639_014350	COG1760	l-serine dehydratase
IXO639_014360	COG0626	cystathionine gamma-synthase activity
IXO639_014365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO639_014370	COG0739	heme binding
IXO639_014380	COG1272	protein, Hemolysin III
IXO639_014400	COG0463	Glycosyl transferase, family 2
IXO639_014410	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO639_014420	COG4771	TonB-dependent receptor
IXO639_014425	COG1309	transcriptional regulator
IXO639_014435	COG1960	acyl-CoA dehydrogenase activity
IXO639_014465	COG0509	glycine decarboxylation via glycine cleavage system
IXO639_014480	COG0330	HflC and HflK could
IXO639_014495	COG3956	TIGRFAM MazG family protein
IXO639_014505	COG0494	nUDIX hydrolase
IXO639_014515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO639_014520	COG0837	glucose binding
IXO639_014535	COG1388	LysM domain
IXO639_014535	COG3858	chitin binding
IXO639_014545	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO639_014555	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO639_014615	COG3537	Alpha-1,2-mannosidase
IXO639_014655	COG3142	Participates in the control of copper homeostasis
IXO639_014660	COG1446	asparaginase
IXO639_014685	COG3039	Transposase
IXO639_014705	COG0643	Histidine kinase
IXO639_014705	COG0784	Response regulator, receiver
IXO639_014705	COG2198	Histidine kinase
IXO639_014710	COG0840	transmembrane signaling receptor activity
IXO639_014715	COG0835	chemotaxis
IXO639_014730	COG0189	ligase activity
IXO639_014740	COG1397	ADP-ribosylglycohydrolase
IXO639_014750	COG1199	ATP-dependent helicase activity
IXO639_014760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO639_014765	COG1215	transferase activity, transferring glycosyl groups
IXO639_014775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO639_014795	COG0535	radical SAM domain protein
IXO639_014800	COG0535	radical SAM domain protein
IXO639_014825	COG1643	Atp-dependent helicase
IXO639_014830	COG0783	Belongs to the Dps family
IXO639_014835	COG0514	ATP-dependent DNA helicase (RecQ)
IXO639_014855	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO639_014905	COG1187	pseudouridine synthase activity
IXO639_014910	COG0602	queuosine metabolic process
IXO639_014920	COG2885	chlorophyll binding
IXO639_014935	COG0848	biopolymer transport protein
IXO639_014945	COG0824	Thioesterase
IXO639_014950	COG2255	four-way junction helicase activity
IXO639_014960	COG0632	four-way junction helicase activity
IXO639_015090	COG3209	COG3209 Rhs family protein
IXO639_015110	COG3209	COG3209 Rhs family protein
IXO639_015110	COG3209	COG3209 Rhs family protein
IXO639_015130	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO639_015135	COG1845	cytochrome c oxidase, subunit III
IXO639_015140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO639_015155	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO639_015160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO639_015170	COG0196	riboflavin kinase activity
IXO639_015175	COG0728	peptidoglycan biosynthetic process
IXO639_015180	COG0268	Binds directly to 16S ribosomal RNA
IXO639_015185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO639_015190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO639_015200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO639_015205	COG0824	Thioesterase
IXO639_015220	COG1946	Acyl-CoA thioesterase
IXO639_015230	COG1595	DNA-templated transcription, initiation
IXO639_015245	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO639_015280	COG1877	trehalose-phosphatase activity
IXO639_015285	COG3387	PFAM Glycoside hydrolase 15-related
IXO639_015310	COG0564	pseudouridine synthase activity
IXO639_015315	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO639_015320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO639_015320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO639_015330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO639_015335	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO639_015375	COG2194	sulfuric ester hydrolase activity
IXO639_015380	COG4969	Belongs to the N-Me-Phe pilin family
IXO639_015390	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO639_015410	COG3039	Transposase
IXO639_015430	COG3039	Transposase
IXO639_015465	COG1132	(ABC) transporter
IXO639_015495	COG0745	RESPONSE REGULATOR receiver
IXO639_015500	COG5002	protein histidine kinase activity
IXO639_015500	COG5000	phosphorelay sensor kinase activity
IXO639_015505	COG0475	glutathione-regulated potassium exporter activity
IXO639_015515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO639_015535	COG1187	pseudouridine synthase activity
IXO639_015540	COG5001	Diguanylate cyclase
IXO639_015540	COG5002	protein histidine kinase activity
IXO639_015645	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_015660	COG0415	Belongs to the DNA photolyase family
IXO639_015665	COG0305	Participates in initiation and elongation during chromosome replication
IXO639_015675	COG0367	asparagine synthase
IXO639_015700	COG1960	acyl-CoA dehydrogenase activity
IXO639_015715	COG0084	hydrolase, TatD family'
IXO639_015720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO639_015780	COG0735	belongs to the Fur family
IXO639_015785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO639_015800	COG3039	Transposase
IXO639_015825	COG3039	Transposase
IXO639_015870	COG2205	protein histidine kinase activity
IXO639_015880	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO639_015890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO639_015905	COG2198	Histidine kinase
IXO639_015905	COG0643	Histidine kinase
IXO639_015910	COG0840	transmembrane signaling receptor activity
IXO639_015915	COG0835	chemotaxis
IXO639_015920	COG2200	EAL domain
IXO639_015920	COG2202	Pas domain
IXO639_015920	COG2199	diguanylate cyclase activity
IXO639_015925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO639_015940	COG3590	peptidase
IXO639_015955	COG0588	phosphoglycerate mutase activity
IXO639_015960	COG1515	deoxyribonuclease V activity
IXO639_015970	COG1741	Belongs to the pirin family
IXO639_016035	COG1741	Belongs to the pirin family
IXO639_016040	COG1966	Carbon starvation protein
IXO639_016045	COG2879	small protein
IXO639_016085	COG5001	Diguanylate cyclase
IXO639_016085	COG4251	negative regulation of phosphorylation
IXO639_016085	COG3706	GGDEF domain
IXO639_016085	COG2203	Gaf domain
IXO639_016090	COG0629	single-stranded DNA binding
IXO639_016095	COG0142	geranyltranstransferase activity
IXO639_016120	COG0527	aspartate kinase activity
IXO639_016130	COG0384	phenazine biosynthesis protein PhzF
IXO639_016140	COG1764	response to oxidative stress
IXO639_016155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO639_016160	COG1678	Uncharacterized ACR, COG1678
IXO639_016170	COG0519	Catalyzes the synthesis of GMP from XMP
IXO639_016200	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO639_016240	COG0693	protein deglycase activity
IXO639_016260	COG1959	2 iron, 2 sulfur cluster binding
IXO639_016265	COG0719	Fe-S assembly protein
IXO639_016270	COG0396	ATPase activity
IXO639_016275	COG0719	Fe-S assembly protein
IXO639_016280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO639_016290	COG2146	nitrite reductase [NAD(P)H] activity
IXO639_016315	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO639_016330	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO639_016340	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO639_016345	COG0174	glutamine synthetase
IXO639_016350	COG3328	transposase activity
IXO639_016375	COG0326	Molecular chaperone. Has ATPase activity
IXO639_016380	COG2207	Transcriptional regulator
IXO639_016410	COG0657	acetylesterase activity
IXO639_016410	COG2755	lipolytic protein G-D-S-L family
IXO639_016435	COG0488	(ABC) transporter
IXO639_016465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO639_016465	COG4651	solute:proton antiporter activity
IXO639_016480	COG4772	TonB-dependent receptor
IXO639_016490	COG4264	IucA IucC family
IXO639_016495	COG2814	Major facilitator Superfamily
IXO639_016505	COG0019	diaminopimelate decarboxylase activity
IXO639_016565	COG4206	TonB-dependent receptor
IXO639_016600	COG0542	response to heat
IXO639_016640	COG0534	Mate efflux family protein
IXO639_016655	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO639_016660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO639_016665	COG0228	four-way junction DNA binding
IXO639_016685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO639_016695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO639_016740	COG1555	photosystem II stabilization
IXO639_016745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO639_016760	COG3178	'Phosphotransferase
IXO639_016765	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO639_016775	COG0628	permease
IXO639_016785	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO639_016800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO639_016820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO639_016825	COG0271	Belongs to the BolA IbaG family
IXO639_016835	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO639_016845	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO639_016850	COG1137	ATPase activity
IXO639_016865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO639_016870	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO639_016875	COG1660	Displays ATPase and GTPase activities
IXO639_016885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO639_016890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO639_016895	COG2239	Acts as a magnesium transporter
IXO639_016905	COG1294	oxidase, subunit
IXO639_016910	COG1271	oxidase subunit
IXO639_016925	COG1113	amino acid transport
IXO639_016940	COG2197	response regulator
IXO639_016945	COG0531	amino acid
IXO639_017000	COG0754	glutathionylspermidine amidase activity
IXO639_017025	COG1842	Phage shock protein A
IXO639_017040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO639_017045	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXO639_017055	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO639_017085	COG2201	protein-glutamate methylesterase activity
IXO639_017125	COG2801	Transposase and inactivated derivatives
IXO639_017140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO639_017190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO639_017195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO639_017220	COG3039	Transposase
IXO639_017235	COG0745	RESPONSE REGULATOR receiver
IXO639_017240	COG2205	protein histidine kinase activity
IXO639_017260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO639_017290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO639_017290	COG3453	Protein conserved in bacteria
IXO639_017295	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO639_017300	COG4149	molybdate abc transporter
IXO639_017305	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO639_017325	COG0642	Histidine kinase
IXO639_017340	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_017350	COG1022	Amp-dependent synthetase and ligase
IXO639_017375	COG1376	ErfK ybiS ycfS ynhG family protein
IXO639_017380	COG0739	heme binding
IXO639_017390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO639_017395	COG1301	dicarboxylic acid transport
IXO639_017415	COG2304	oxidoreductase activity
IXO639_017435	COG0714	Associated with various cellular activities
IXO639_017480	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO639_017505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO639_017515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO639_017540	COG1561	YicC-like family, N-terminal region
IXO639_017545	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO639_017560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO639_017595	COG0006	proline dipeptidase activity
IXO639_017620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO639_017630	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO639_017640	COG2912	Transglutaminase-like superfamily
IXO639_017645	COG1773	rubredoxin
IXO639_017650	COG0352	thiamine-phosphate diphosphorylase activity
IXO639_017720	COG0281	malic enzyme
IXO639_017720	COG0280	phosphate acetyltransferase
IXO639_017740	COG4191	Histidine kinase
IXO639_017755	COG0583	DNA-binding transcription factor activity
IXO639_017770	COG2197	response regulator
IXO639_017780	COG0642	Histidine kinase
IXO639_017800	COG2851	Citrate transporter
IXO639_017805	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_017810	COG1609	Transcriptional regulator
IXO639_017820	COG2211	Major facilitator Superfamily
IXO639_017845	COG1162	GTPase activity
IXO639_017870	COG0726	polysaccharide deacetylase
IXO639_017875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO639_017900	COG3039	Transposase
IXO639_017905	COG3039	Transposase
IXO639_017950	COG0242	peptide deformylase activity
IXO639_017970	COG0714	Associated with various cellular activities
IXO639_017990	COG0537	adenosine 5'-monophosphoramidase activity
IXO639_018020	COG0314	molybdopterin synthase activity
IXO639_018025	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO639_018030	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO639_018040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO639_018045	COG1234	tRNA 3'-trailer cleavage
IXO639_018050	COG3642	lipopolysaccharide core region biosynthetic process
IXO639_018055	COG0859	PFAM glycosyl transferase family 9
IXO639_018065	COG0582	viral genome integration into host DNA
IXO639_018125	COG0631	protein serine/threonine phosphatase activity
IXO639_018135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO639_018160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO639_018200	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO639_018250	COG0473	3-isopropylmalate dehydrogenase activity
IXO639_018275	COG4783	chaperone-mediated protein folding
IXO639_018290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO639_018300	COG0438	transferase activity, transferring glycosyl groups
IXO639_018305	COG0671	phosphoesterase, PA-phosphatase related
IXO639_018310	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO639_018330	COG2833	Protein of unknown function (DUF455)
IXO639_018350	COG0285	dihydrofolate synthase activity
IXO639_018360	COG0588	phosphoglycerate mutase activity
IXO639_018390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO639_018395	COG4208	sulfate ABC transporter
IXO639_018400	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO639_018405	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO639_018410	COG0156	8-amino-7-oxononanoate synthase activity
IXO639_018435	COG0604	alcohol dehydrogenase
IXO639_018440	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO639_018440	COG1902	pentaerythritol trinitrate reductase activity
IXO639_018530	COG0697	spore germination
IXO639_018560	COG3386	PFAM SMP-30 Gluconolaconase
IXO639_018580	COG1024	Enoyl-CoA hydratase
IXO639_018590	COG0318	PFAM AMP-dependent synthetase and ligase
IXO639_018595	COG0583	DNA-binding transcription factor activity
IXO639_018635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO639_018640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO639_018650	COG2096	Adenosyltransferase
IXO639_018655	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO639_018670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO639_018680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO639_018685	COG2967	ApaG domain
IXO639_018710	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO639_018730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO639_018755	COG0642	Histidine kinase
IXO639_018770	COG4181	ATPase activity
IXO639_018780	COG2175	clavaminate synthase activity
IXO639_018835	COG0667	Aldo Keto reductase
IXO639_018845	COG3039	Transposase
IXO639_018855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO639_018860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO639_018870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO639_018885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO639_018930	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO639_018935	COG2226	methyltransferase
IXO639_018980	COG3321	synthase
IXO639_018980	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_018980	COG0604	alcohol dehydrogenase
IXO639_018990	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO639_019005	COG0494	nUDIX hydrolase
IXO639_019020	COG4942	peptidase
IXO639_019020	COG1388	LysM domain
IXO639_019030	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO639_019045	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO639_019050	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO639_019055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO639_019070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO639_019075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO639_019090	COG3116	cell division
IXO639_019095	COG0275	rRNA processing
IXO639_019130	COG0792	nuclease activity
IXO639_019135	COG1988	membrane-bound metal-dependent
IXO639_019140	COG0277	FAD linked oxidase domain protein
IXO639_019145	COG0745	RESPONSE REGULATOR receiver
IXO639_019150	COG2205	protein histidine kinase activity
IXO639_019160	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO639_019165	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO639_019185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO639_019190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO639_019195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO639_019215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO639_019215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO639_019235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO639_019255	COG0488	(ABC) transporter
IXO639_019265	COG3039	Transposase
IXO639_019310	COG2205	protein histidine kinase activity
IXO639_019355	COG2205	protein histidine kinase activity
IXO639_019370	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO639_019405	COG3039	Transposase
IXO639_019425	COG3039	Transposase
IXO639_019505	COG1649	PFAM Uncharacterised BCR, COG1649
IXO639_019505	COG0726	polysaccharide deacetylase
IXO639_019510	COG1215	transferase activity, transferring glycosyl groups
IXO639_019520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO639_019525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO639_019530	COG1609	Transcriptional regulator
IXO639_019540	COG2188	Transcriptional regulator
IXO639_019555	COG3250	beta-galactosidase activity
IXO639_019605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO639_019610	COG4191	Histidine kinase
IXO639_019615	COG0784	Response regulator, receiver
IXO639_019620	COG4251	negative regulation of phosphorylation
IXO639_019625	COG2823	Periplasmic or secreted lipoprotein
IXO639_019630	COG0673	inositol 2-dehydrogenase activity
IXO639_019635	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO639_019670	COG1056	cytidyltransferase-related domain
IXO639_019670	COG1051	belongs to the nudix hydrolase family
IXO639_019695	COG2921	Belongs to the UPF0250 family
IXO639_019710	COG1686	Belongs to the peptidase S11 family
IXO639_019715	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO639_019720	COG2951	lytic endotransglycosylase activity
IXO639_019790	COG0772	Belongs to the SEDS family
IXO639_019805	COG1792	Involved in formation and maintenance of cell shape
IXO639_019810	COG1077	Cell shape determining protein MreB Mrl
IXO639_019815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO639_019865	COG2199	diguanylate cyclase activity
IXO639_019870	COG0308	aminopeptidase N
IXO639_019900	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO639_019930	COG0436	Aminotransferase
IXO639_019955	COG1505	serine-type exopeptidase activity
IXO639_019980	COG0181	hydroxymethylbilane synthase activity
IXO639_019990	COG3275	phosphorelay sensor kinase activity
IXO639_020025	COG0659	secondary active sulfate transmembrane transporter activity
IXO639_020030	COG5297	Belongs to the glycosyl hydrolase family 6
IXO639_020030	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO639_020105	COG0598	Magnesium transport protein CorA
IXO639_020115	COG1113	amino acid transport
IXO639_020125	COG5297	Belongs to the glycosyl hydrolase family 6
IXO639_020130	COG4305	rare lipoprotein A
IXO639_020135	COG0697	spore germination
IXO639_020195	COG4221	oxidoreductase activity
IXO639_020225	COG0456	acetyltransferase
IXO639_020235	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO639_020280	COG2111	Na H antiporter
IXO639_020280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO639_020285	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO639_020290	COG0651	ATP synthesis coupled electron transport
IXO639_020300	COG2212	antiporter activity
IXO639_020305	COG1320	monovalent cation:proton antiporter activity
IXO639_020315	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO639_020335	COG3104	oligopeptide transport
IXO639_020340	COG3483	tryptophan 2,3-dioxygenase activity
IXO639_020350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IXO639_020390	COG0183	Belongs to the thiolase family
IXO639_020460	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO639_020465	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO639_020475	COG4948	Mandelate Racemase Muconate Lactonizing
IXO639_020500	COG0531	amino acid
IXO639_020530	COG4682	membrane
IXO639_020535	COG2133	pyrroloquinoline quinone binding
IXO639_020575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO639_020580	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO639_020590	COG1610	YqeY-like protein
IXO639_020605	COG1295	ribonuclease BN
IXO639_020610	COG0358	DNA primase activity
IXO639_020675	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO639_020690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO639_020740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO639_020745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO639_020750	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO639_020760	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO639_020765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO639_020775	COG0134	indole-3-glycerol-phosphate synthase activity
IXO639_020780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO639_020840	COG3039	Transposase
IXO639_020855	COG3039	Transposase
IXO639_020875	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO639_020875	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO639_020885	COG1473	amidohydrolase
IXO639_020890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO639_020895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO639_020905	COG5383	Protein conserved in bacteria
IXO639_020940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO639_020945	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO639_020960	COG0028	Belongs to the TPP enzyme family
IXO639_020965	COG4191	Histidine kinase
IXO639_020990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO639_021005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO639_021010	COG3177	Filamentation induced by cAMP protein fic
IXO639_021025	COG0596	Alpha beta hydrolase
IXO639_021030	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO639_021035	COG0318	PFAM AMP-dependent synthetase and ligase
IXO639_021040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO639_021090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO639_021100	COG0129	dihydroxy-acid dehydratase activity
IXO639_021120	COG3039	Transposase
IXO639_021130	COG0408	coproporphyrinogen oxidase activity
IXO639_021170	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXO639_021230	COG2353	YceI-like domain
IXO639_021235	COG0778	Nitroreductase
IXO639_021270	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO639_021285	COG3386	PFAM SMP-30 Gluconolaconase
IXO639_021325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO639_021345	COG0459	protein refolding
IXO639_021370	COG1252	NADH dehydrogenase
IXO639_021380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO639_021385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO639_021390	COG2201	protein-glutamate methylesterase activity
IXO639_021395	COG2177	Part of the ABC transporter FtsEX involved in
IXO639_021400	COG2884	Cell division ATP-binding protein ftsE
IXO639_021410	COG3118	belongs to the thioredoxin family
IXO639_021415	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO639_021430	COG0729	surface antigen
IXO639_021435	COG2911	Protein conserved in bacteria
IXO639_021470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO639_021485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO639_021540	COG1733	regulation of RNA biosynthetic process
IXO639_021545	COG0702	epimerase
IXO639_021575	COG0583	DNA-binding transcription factor activity
IXO639_021580	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO639_021600	COG0745	RESPONSE REGULATOR receiver
IXO639_021630	COG1902	pentaerythritol trinitrate reductase activity
IXO639_021635	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO639_021645	COG2814	Major facilitator Superfamily
IXO639_021650	COG0583	DNA-binding transcription factor activity
IXO639_021665	COG0084	hydrolase, TatD family'
IXO639_021710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO639_021730	COG2072	flavoprotein involved in K transport
IXO639_021790	COG4770	biotin carboxylase activity
IXO639_021795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO639_021800	COG1960	acyl-CoA dehydrogenase activity
IXO639_021855	COG0523	cobalamin synthesis protein
IXO639_021865	COG0697	spore germination
IXO639_021875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO639_021890	COG4771	TonB-dependent receptor
IXO639_021895	COG0457	Tetratricopeptide repeat
IXO639_021905	COG0752	glycyl-tRNA synthetase alpha subunit
IXO639_021910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO639_021925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO639_021925	COG0519	Catalyzes the synthesis of GMP from XMP
IXO639_021935	COG0805	protein transport
IXO639_021945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO639_021955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO639_021980	COG2974	May be involved in recombination
IXO639_021985	COG0037	tRNA processing
IXO639_022000	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO639_022010	COG4948	Mandelate Racemase Muconate Lactonizing
IXO639_022020	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO639_022025	COG0246	Mannitol dehydrogenase
IXO639_022050	COG3693	PFAM glycoside hydrolase, family 10
IXO639_022070	COG2211	Major facilitator Superfamily
IXO639_022115	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IXO639_022155	COG1846	Transcriptional regulator
IXO639_022160	COG1764	response to oxidative stress
IXO639_022235	COG3549	Plasmid maintenance system killer
IXO639_022245	COG1074	ATP-dependent DNA helicase activity
IXO639_022250	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO639_022295	COG2032	superoxide dismutase activity
IXO639_022300	COG2032	superoxide dismutase activity
IXO639_022305	COG2204	response regulator
IXO639_022310	COG3852	Histidine kinase
IXO639_022315	COG0004	ammonium transporteR
IXO639_022320	COG0347	Belongs to the P(II) protein family
IXO639_022325	COG0174	glutamine synthetase
IXO639_022330	COG1968	undecaprenyl-diphosphatase activity
IXO639_022375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO639_022385	COG2062	phosphohistidine phosphatase, SixA
IXO639_022390	COG0489	protein tyrosine kinase activity
IXO639_022410	COG1396	sequence-specific DNA binding
IXO639_022415	COG3550	peptidyl-serine autophosphorylation
IXO639_022420	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO639_022425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO639_022440	COG0517	IMP dehydrogenase activity
IXO639_022440	COG1125	glycine betaine transport
IXO639_022455	COG1119	ATPase activity
IXO639_022465	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO639_022480	COG3039	Transposase
IXO639_022505	COG0656	L-ascorbic acid biosynthetic process
IXO639_022510	COG2130	NADP-dependent
IXO639_022515	COG0667	Aldo Keto reductase
IXO639_022525	COG1187	pseudouridine synthase activity
IXO639_022535	COG1643	Atp-dependent helicase
IXO639_022540	COG4807	Protein conserved in bacteria
IXO639_022545	COG4948	Mandelate Racemase Muconate Lactonizing
IXO639_022550	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO639_022555	COG1028	Short-chain dehydrogenase reductase Sdr
IXO639_022575	COG3507	Belongs to the glycosyl hydrolase 43 family
IXO639_022615	COG3162	membrane
IXO639_022620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO639_022635	COG0708	Exodeoxyribonuclease III
IXO639_022650	COG2091	lysine biosynthetic process via aminoadipic acid
IXO639_022660	COG3540	Alkaline phosphatase
IXO639_022665	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO639_022690	COG2159	amidohydrolase
IXO639_022700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO639_022705	COG0583	DNA-binding transcription factor activity
IXO639_022710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO639_022725	COG0210	DNA helicase
IXO639_022745	COG0531	amino acid
IXO639_022750	COG1322	Protein conserved in bacteria
IXO639_022760	COG0386	Belongs to the glutathione peroxidase family
IXO639_022815	COG0793	Belongs to the peptidase S41A family
IXO639_022820	COG4942	peptidase
IXO639_022830	COG2234	aminopeptidase activity
IXO639_022875	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO639_022880	COG0302	gtp cyclohydrolase
IXO639_022900	COG0477	Major facilitator Superfamily
IXO639_022915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO639_022975	COG1929	Belongs to the glycerate kinase type-1 family
IXO639_022980	COG2271	Major facilitator Superfamily
IXO639_022995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO639_023000	COG0861	Integral membrane protein TerC family
IXO639_023015	COG0584	glycerophosphoryl diester phosphodiesterase
IXO639_023025	COG0671	phosphoesterase, PA-phosphatase related
IXO639_023030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IXO639_023035	COG0726	polysaccharide deacetylase