locus-tag	class	description
IXO651_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO651_000020	COG0187	DNA topoisomerase II activity
IXO651_000030	COG0501	Belongs to the peptidase M48B family
IXO651_000070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO651_000080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO651_000090	COG4772	TonB-dependent receptor
IXO651_000105	COG3039	Transposase
IXO651_000110	COG1304	FMN binding
IXO651_000130	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO651_000145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO651_000240	COG2826	transposase and inactivated derivatives, IS30 family
IXO651_000265	COG3039	Transposase
IXO651_000275	COG1090	epimerase
IXO651_000285	COG0642	Histidine kinase
IXO651_000295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO651_000405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO651_000490	COG1511	domain protein
IXO651_000490	COG3264	Mechanosensitive ion channel
IXO651_000505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO651_000510	COG2354	Protein conserved in bacteria
IXO651_000515	COG1649	PFAM Uncharacterised BCR, COG1649
IXO651_000535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO651_000560	COG0702	epimerase
IXO651_000575	COG1858	cytochrome C peroxidase
IXO651_000650	COG0513	Belongs to the DEAD box helicase family
IXO651_000655	COG3039	Transposase
IXO651_000705	COG1136	(ABC) transporter
IXO651_000745	COG1136	(ABC) transporter
IXO651_000785	COG1272	protein, Hemolysin III
IXO651_000790	COG1111	helicase
IXO651_000790	COG1205	dead DEAH box helicase
IXO651_000850	COG0069	glutamate synthase activity
IXO651_000850	COG0070	glutamate synthase
IXO651_000850	COG0067	glutamate synthase
IXO651_000855	COG0493	'glutamate synthase
IXO651_000900	COG1609	Transcriptional regulator
IXO651_000925	COG0366	Alpha amylase catalytic
IXO651_000930	COG0366	Alpha amylase catalytic
IXO651_000970	COG0606	chelatase, subunit chli
IXO651_001015	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO651_001020	COG1166	arginine decarboxylase activity
IXO651_001070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO651_001095	COG1028	Short-chain dehydrogenase reductase Sdr
IXO651_001120	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO651_001135	COG0210	DNA helicase
IXO651_001150	COG3132	Protein of unknown function, DUF480
IXO651_001155	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO651_001160	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO651_001195	COG2937	Belongs to the GPAT DAPAT family
IXO651_001240	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO651_001250	COG1119	ATPase activity
IXO651_001265	COG0517	IMP dehydrogenase activity
IXO651_001265	COG1125	glycine betaine transport
IXO651_001280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO651_001285	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO651_001290	COG3550	peptidyl-serine autophosphorylation
IXO651_001295	COG1396	sequence-specific DNA binding
IXO651_001315	COG0489	protein tyrosine kinase activity
IXO651_001320	COG2062	phosphohistidine phosphatase, SixA
IXO651_001330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO651_001375	COG1968	undecaprenyl-diphosphatase activity
IXO651_001380	COG0174	glutamine synthetase
IXO651_001385	COG0347	Belongs to the P(II) protein family
IXO651_001390	COG0004	ammonium transporteR
IXO651_001395	COG3852	Histidine kinase
IXO651_001400	COG2204	response regulator
IXO651_001405	COG2032	superoxide dismutase activity
IXO651_001410	COG2032	superoxide dismutase activity
IXO651_001445	COG1196	nuclear chromosome segregation
IXO651_001455	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO651_001460	COG1074	ATP-dependent DNA helicase activity
IXO651_001470	COG3549	Plasmid maintenance system killer
IXO651_001545	COG1764	response to oxidative stress
IXO651_001550	COG1846	Transcriptional regulator
IXO651_001595	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IXO651_001635	COG2211	Major facilitator Superfamily
IXO651_001655	COG3693	PFAM glycoside hydrolase, family 10
IXO651_001680	COG0246	Mannitol dehydrogenase
IXO651_001685	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO651_001695	COG4948	Mandelate Racemase Muconate Lactonizing
IXO651_001705	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO651_001720	COG0037	tRNA processing
IXO651_001725	COG2974	May be involved in recombination
IXO651_001750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO651_001760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO651_001770	COG0805	protein transport
IXO651_001780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO651_001780	COG0519	Catalyzes the synthesis of GMP from XMP
IXO651_001795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO651_001800	COG0752	glycyl-tRNA synthetase alpha subunit
IXO651_001810	COG0457	Tetratricopeptide repeat
IXO651_001815	COG4771	TonB-dependent receptor
IXO651_001835	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO651_001845	COG0697	spore germination
IXO651_001855	COG0523	cobalamin synthesis protein
IXO651_001905	COG1960	acyl-CoA dehydrogenase activity
IXO651_001910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO651_001915	COG4770	biotin carboxylase activity
IXO651_001965	COG2072	flavoprotein involved in K transport
IXO651_001985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO651_002030	COG0084	hydrolase, TatD family'
IXO651_002045	COG0583	DNA-binding transcription factor activity
IXO651_002070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO651_002075	COG1902	pentaerythritol trinitrate reductase activity
IXO651_002105	COG0745	RESPONSE REGULATOR receiver
IXO651_002125	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO651_002130	COG0583	DNA-binding transcription factor activity
IXO651_002160	COG0702	epimerase
IXO651_002165	COG1733	regulation of RNA biosynthetic process
IXO651_002200	COG3039	Transposase
IXO651_002220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO651_002235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO651_002270	COG2911	Protein conserved in bacteria
IXO651_002275	COG0729	surface antigen
IXO651_002290	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO651_002295	COG3118	belongs to the thioredoxin family
IXO651_002305	COG2884	Cell division ATP-binding protein ftsE
IXO651_002310	COG2177	Part of the ABC transporter FtsEX involved in
IXO651_002315	COG2201	protein-glutamate methylesterase activity
IXO651_002320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO651_002325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO651_002335	COG1252	NADH dehydrogenase
IXO651_002360	COG0459	protein refolding
IXO651_002370	COG4771	TonB-dependent receptor
IXO651_002385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO651_002430	COG3386	PFAM SMP-30 Gluconolaconase
IXO651_002445	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO651_002475	COG2353	YceI-like domain
IXO651_002580	COG0408	coproporphyrinogen oxidase activity
IXO651_002590	COG3039	Transposase
IXO651_002610	COG0129	dihydroxy-acid dehydratase activity
IXO651_002620	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO651_002650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO651_002655	COG0318	PFAM AMP-dependent synthetase and ligase
IXO651_002660	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO651_002665	COG0596	Alpha beta hydrolase
IXO651_002680	COG3177	Filamentation induced by cAMP protein fic
IXO651_002685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO651_002700	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO651_002725	COG4191	Histidine kinase
IXO651_002730	COG0028	Belongs to the TPP enzyme family
IXO651_002745	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO651_002750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO651_002775	COG5383	Protein conserved in bacteria
IXO651_002785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO651_002790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO651_002795	COG1473	amidohydrolase
IXO651_002805	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO651_002805	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO651_002810	COG3328	transposase activity
IXO651_002830	COG3039	Transposase
IXO651_002890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO651_002905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO651_002910	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO651_002920	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO651_002925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO651_002930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO651_002980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO651_002995	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO651_003055	COG3039	Transposase
IXO651_003075	COG1294	oxidase, subunit
IXO651_003080	COG1271	oxidase subunit
IXO651_003090	COG2204	response regulator
IXO651_003140	COG2972	Histidine kinase
IXO651_003155	COG0531	amino acid
IXO651_003175	COG3590	peptidase
IXO651_003185	COG0667	Aldo Keto reductase
IXO651_003200	COG3384	dioxygenase
IXO651_003210	COG1573	uracil-dna glycosylase
IXO651_003220	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO651_003235	COG0025	NhaP-type Na H and K H
IXO651_003240	COG1131	(ABC) transporter
IXO651_003245	COG0842	Transport permease protein
IXO651_003260	COG1404	Belongs to the peptidase S8 family
IXO651_003275	COG0745	RESPONSE REGULATOR receiver
IXO651_003325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO651_003350	COG2205	protein histidine kinase activity
IXO651_003350	COG2202	Pas domain
IXO651_003380	COG2813	Specifically methylates the guanine in position
IXO651_003385	COG1187	pseudouridine synthase activity
IXO651_003390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO651_003425	COG0697	spore germination
IXO651_003435	COG2011	ABC-type metal ion transport system permease component
IXO651_003465	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO651_003475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO651_003495	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO651_003505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO651_003515	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO651_003520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO651_003525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO651_003580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO651_003585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO651_003635	COG0339	signal peptide processing
IXO651_003670	COG1956	GAF domain-containing protein
IXO651_003675	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO651_003685	COG0720	synthase
IXO651_003690	COG0513	Belongs to the DEAD box helicase family
IXO651_003700	COG0625	glutathione transferase activity
IXO651_003730	COG0626	cystathionine gamma-synthase activity
IXO651_003750	COG0438	transferase activity, transferring glycosyl groups
IXO651_003750	COG1216	Glycosyl transferase, family 2
IXO651_003785	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IXO651_003790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO651_003805	COG0277	FAD linked oxidase domain protein
IXO651_003810	COG0546	phosphoglycolate phosphatase activity
IXO651_003810	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO651_003825	COG2086	electron transfer activity
IXO651_003850	COG0662	Cupin 2, conserved barrel domain protein
IXO651_003850	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO651_003855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO651_003890	COG3218	ABC-type transport auxiliary lipoprotein component
IXO651_003890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO651_003895	COG1127	ABC transporter
IXO651_003900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO651_003915	COG0442	prolyl-tRNA aminoacylation
IXO651_003925	COG1183	phosphatidylcholine synthase activity
IXO651_003955	COG3039	Transposase
IXO651_003980	COG3039	Transposase
IXO651_004010	COG0525	valine-tRNA ligase activity
IXO651_004025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO651_004035	COG0795	lipopolysaccharide-transporting ATPase activity
IXO651_004045	COG4974	Belongs to the 'phage' integrase family
IXO651_004050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO651_004055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXO651_004055	COG0047	phosphoribosylformylglycinamidine synthase activity
IXO651_004060	COG5295	Hep Hag repeat protein
IXO651_004070	COG1404	Belongs to the peptidase S8 family
IXO651_004080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO651_004090	COG1459	type II secretion system
IXO651_004095	COG2165	general secretion pathway protein
IXO651_004100	COG4970	Tfp pilus assembly protein FimT
IXO651_004105	COG2165	general secretion pathway protein
IXO651_004110	COG4795	General secretion pathway protein
IXO651_004115	COG3156	type II secretion system protein K
IXO651_004120	COG3166	PFAM Fimbrial assembly family protein
IXO651_004135	COG1450	Type ii and iii secretion system protein
IXO651_004150	COG2188	Transcriptional regulator
IXO651_004200	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO651_004205	COG1518	maintenance of DNA repeat elements
IXO651_004245	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO651_004270	COG1028	Short-chain dehydrogenase reductase Sdr
IXO651_004275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO651_004285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO651_004290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO651_004320	COG3829	transcription factor binding
IXO651_004365	COG3039	Transposase
IXO651_004395	COG2826	transposase and inactivated derivatives, IS30 family
IXO651_004405	COG0678	peroxiredoxin activity
IXO651_004425	COG0330	HflC and HflK could
IXO651_004430	COG0330	HflC and HflK could
IXO651_004440	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO651_004445	COG0308	aminopeptidase N
IXO651_004495	COG1560	Kdo2-lipid A biosynthetic process
IXO651_004500	COG1519	Transferase
IXO651_004505	COG1538	Outer membrane efflux protein
IXO651_004510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO651_004540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO651_004545	COG0066	3-isopropylmalate dehydratase activity
IXO651_004580	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO651_004590	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO651_004595	COG3710	Transcriptional regulator
IXO651_004620	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO651_004640	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO651_004670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO651_004680	COG3781	membrane
IXO651_004830	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO651_004850	COG1217	gtp-binding protein TYPA
IXO651_004855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO651_004860	COG0039	L-malate dehydrogenase activity
IXO651_004865	COG0625	glutathione transferase activity
IXO651_004890	COG3039	Transposase
IXO651_004910	COG0584	glycerophosphoryl diester phosphodiesterase
IXO651_004940	COG1902	pentaerythritol trinitrate reductase activity
IXO651_004940	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO651_004945	COG0604	alcohol dehydrogenase
IXO651_004970	COG0156	8-amino-7-oxononanoate synthase activity
IXO651_004975	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO651_004980	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO651_004985	COG4208	sulfate ABC transporter
IXO651_004990	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO651_005025	COG0588	phosphoglycerate mutase activity
IXO651_005035	COG0285	dihydrofolate synthase activity
IXO651_005055	COG2833	Protein of unknown function (DUF455)
IXO651_005075	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO651_005080	COG0671	phosphoesterase, PA-phosphatase related
IXO651_005085	COG0438	transferase activity, transferring glycosyl groups
IXO651_005095	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO651_005110	COG4783	chaperone-mediated protein folding
IXO651_005135	COG0473	3-isopropylmalate dehydrogenase activity
IXO651_005185	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO651_005225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO651_005250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO651_005260	COG0631	protein serine/threonine phosphatase activity
IXO651_005315	COG0582	viral genome integration into host DNA
IXO651_005325	COG0859	PFAM glycosyl transferase family 9
IXO651_005330	COG3642	lipopolysaccharide core region biosynthetic process
IXO651_005335	COG1234	tRNA 3'-trailer cleavage
IXO651_005340	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO651_005350	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO651_005355	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO651_005360	COG0314	molybdopterin synthase activity
IXO651_005390	COG0537	adenosine 5'-monophosphoramidase activity
IXO651_005410	COG0714	Associated with various cellular activities
IXO651_005430	COG0242	peptide deformylase activity
IXO651_005480	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO651_005485	COG0726	polysaccharide deacetylase
IXO651_005535	COG2211	Major facilitator Superfamily
IXO651_005545	COG1609	Transcriptional regulator
IXO651_005550	COG1028	Short-chain dehydrogenase reductase Sdr
IXO651_005555	COG2851	Citrate transporter
IXO651_005570	COG0642	Histidine kinase
IXO651_005580	COG2197	response regulator
IXO651_005595	COG0583	DNA-binding transcription factor activity
IXO651_005610	COG4191	Histidine kinase
IXO651_005630	COG0280	phosphate acetyltransferase
IXO651_005630	COG0281	malic enzyme
IXO651_005690	COG0352	thiamine-phosphate diphosphorylase activity
IXO651_005695	COG1773	rubredoxin
IXO651_005700	COG2912	Transglutaminase-like superfamily
IXO651_005710	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO651_005720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO651_005745	COG0006	proline dipeptidase activity
IXO651_005780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO651_005795	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO651_005800	COG1561	YicC-like family, N-terminal region
IXO651_005825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO651_005835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO651_005860	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO651_005910	COG0714	Associated with various cellular activities
IXO651_005930	COG2304	oxidoreductase activity
IXO651_005950	COG1301	dicarboxylic acid transport
IXO651_005955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO651_005965	COG0739	heme binding
IXO651_005970	COG1376	ErfK ybiS ycfS ynhG family protein
IXO651_005995	COG1022	Amp-dependent synthetase and ligase
IXO651_006005	COG1028	Short-chain dehydrogenase reductase Sdr
IXO651_006020	COG0642	Histidine kinase
IXO651_006040	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO651_006045	COG4149	molybdate abc transporter
IXO651_006050	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO651_006055	COG3453	Protein conserved in bacteria
IXO651_006055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO651_006095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO651_006115	COG2205	protein histidine kinase activity
IXO651_006120	COG0745	RESPONSE REGULATOR receiver
IXO651_006145	COG3039	Transposase
IXO651_006185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO651_006190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO651_006240	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO651_006265	COG2201	protein-glutamate methylesterase activity
IXO651_006355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO651_006370	COG1842	Phage shock protein A
IXO651_006395	COG0754	glutathionylspermidine amidase activity
IXO651_006450	COG0531	amino acid
IXO651_006455	COG2197	response regulator
IXO651_006470	COG1113	amino acid transport
IXO651_006485	COG1271	oxidase subunit
IXO651_006490	COG1294	oxidase, subunit
IXO651_006500	COG2239	Acts as a magnesium transporter
IXO651_006505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO651_006510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO651_006520	COG1660	Displays ATPase and GTPase activities
IXO651_006525	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO651_006530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO651_006545	COG1137	ATPase activity
IXO651_006550	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO651_006560	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO651_006570	COG0271	Belongs to the BolA IbaG family
IXO651_006575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO651_006595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO651_006610	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO651_006620	COG0628	permease
IXO651_006630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO651_006635	COG3178	'Phosphotransferase
IXO651_006650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO651_006655	COG1555	photosystem II stabilization
IXO651_006700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO651_006720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO651_006740	COG0228	four-way junction DNA binding
IXO651_006745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO651_006750	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO651_006765	COG0534	Mate efflux family protein
IXO651_006780	COG3039	Transposase
IXO651_006805	COG0542	response to heat
IXO651_006840	COG4206	TonB-dependent receptor
IXO651_006900	COG0019	diaminopimelate decarboxylase activity
IXO651_006910	COG2814	Major facilitator Superfamily
IXO651_006915	COG4264	IucA IucC family
IXO651_006925	COG4772	TonB-dependent receptor
IXO651_006940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO651_006940	COG4651	solute:proton antiporter activity
IXO651_006965	COG0488	(ABC) transporter
IXO651_006990	COG2755	lipolytic protein G-D-S-L family
IXO651_006990	COG0657	acetylesterase activity
IXO651_007015	COG2207	Transcriptional regulator
IXO651_007020	COG0326	Molecular chaperone. Has ATPase activity
IXO651_007045	COG3328	transposase activity
IXO651_007050	COG0174	glutamine synthetase
IXO651_007055	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO651_007065	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO651_007080	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO651_007115	COG2146	nitrite reductase [NAD(P)H] activity
IXO651_007125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO651_007130	COG0719	Fe-S assembly protein
IXO651_007135	COG0396	ATPase activity
IXO651_007140	COG0719	Fe-S assembly protein
IXO651_007145	COG1959	2 iron, 2 sulfur cluster binding
IXO651_007165	COG0693	protein deglycase activity
IXO651_007205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO651_007235	COG0519	Catalyzes the synthesis of GMP from XMP
IXO651_007245	COG1678	Uncharacterized ACR, COG1678
IXO651_007250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO651_007265	COG1764	response to oxidative stress
IXO651_007275	COG0384	phenazine biosynthesis protein PhzF
IXO651_007285	COG0527	aspartate kinase activity
IXO651_007310	COG0142	geranyltranstransferase activity
IXO651_007315	COG0629	single-stranded DNA binding
IXO651_007320	COG2203	Gaf domain
IXO651_007320	COG3706	GGDEF domain
IXO651_007320	COG5001	Diguanylate cyclase
IXO651_007320	COG4251	negative regulation of phosphorylation
IXO651_007355	COG2879	small protein
IXO651_007360	COG1966	Carbon starvation protein
IXO651_007365	COG1741	Belongs to the pirin family
IXO651_007420	COG3179	chitinase
IXO651_007440	COG3039	Transposase
IXO651_007560	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO651_007565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO651_007570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO651_007575	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO651_007595	COG0101	tRNA pseudouridine synthase activity
IXO651_007600	COG0135	phosphoribosylanthranilate isomerase activity
IXO651_007610	COG0133	tryptophan synthase activity
IXO651_007620	COG0159	tryptophan synthase activity
IXO651_007625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO651_007630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO651_007680	COG0149	triose-phosphate isomerase activity
IXO651_007695	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO651_007705	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO651_007710	COG0649	NAD binding
IXO651_007715	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO651_007720	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO651_007725	COG1034	ATP synthesis coupled electron transport
IXO651_007730	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO651_007760	COG1007	ATP synthesis coupled electron transport
IXO651_007770	COG0779	Required for maturation of 30S ribosomal subunits
IXO651_007775	COG0195	Participates in both transcription termination and antitermination
IXO651_007795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO651_007800	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO651_007835	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO651_007845	COG2095	MarC family integral membrane protein
IXO651_007860	COG1611	Belongs to the LOG family
IXO651_007975	COG1192	Involved in chromosome partitioning
IXO651_008080	COG3179	chitinase
IXO651_008125	COG4695	Portal protein
IXO651_008190	COG4969	Belongs to the N-Me-Phe pilin family
IXO651_008195	COG0556	nucleotide-excision repair
IXO651_008230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO651_008240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IXO651_008245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO651_008300	COG0438	transferase activity, transferring glycosyl groups
IXO651_008305	COG0438	transferase activity, transferring glycosyl groups
IXO651_008315	COG0438	transferase activity, transferring glycosyl groups
IXO651_008355	COG3040	lipid binding
IXO651_008445	COG4191	Histidine kinase
IXO651_008445	COG0784	Response regulator, receiver
IXO651_008465	COG0552	protein localization to endoplasmic reticulum
IXO651_008475	COG3938	Belongs to the proline racemase family
IXO651_008480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO651_008495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO651_008505	COG0006	proline dipeptidase activity
IXO651_008520	COG0531	amino acid
IXO651_008570	COG4206	TonB-dependent receptor
IXO651_008630	COG3039	Transposase
IXO651_008655	COG0746	molybdenum cofactor guanylyltransferase activity
IXO651_008680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO651_008680	COG1648	precorrin-2 dehydrogenase activity
IXO651_008720	COG3039	Transposase
IXO651_008755	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO651_008775	COG1054	Belongs to the UPF0176 family
IXO651_008790	COG1530	ribonuclease E activity
IXO651_008800	COG3064	Membrane
IXO651_008805	COG0428	transporter
IXO651_008810	COG0428	transporter
IXO651_008820	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO651_008825	COG0316	Belongs to the HesB IscA family
IXO651_008825	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IXO651_008850	COG3039	Transposase
IXO651_008855	COG3039	Transposase
IXO651_008890	COG3039	Transposase
IXO651_009000	COG0631	protein serine/threonine phosphatase activity
IXO651_009005	COG0515	serine threonine protein kinase
IXO651_009035	COG1858	cytochrome C peroxidase
IXO651_009085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO651_009090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO651_009110	COG2201	protein-glutamate methylesterase activity
IXO651_009125	COG2201	protein-glutamate methylesterase activity
IXO651_009155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO651_009175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO651_009190	COG1595	DNA-templated transcription, initiation
IXO651_009240	COG2244	polysaccharide biosynthetic process
IXO651_009270	COG2264	protein methyltransferase activity
IXO651_009280	COG0438	transferase activity, transferring glycosyl groups
IXO651_009295	COG1136	(ABC) transporter
IXO651_009300	COG1132	(ABC) transporter
IXO651_009310	COG0477	Major facilitator Superfamily
IXO651_009320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO651_009335	COG1253	flavin adenine dinucleotide binding
IXO651_009345	COG0306	phosphate transporter
IXO651_009375	COG0504	CTP synthase activity
IXO651_009380	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO651_009390	COG0148	phosphopyruvate hydratase activity
IXO651_009395	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO651_009400	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO651_009410	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO651_009420	COG2840	Smr protein MutS2
IXO651_009425	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO651_009430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO651_009435	COG1238	metal cluster binding
IXO651_009450	COG1534	Rna-binding protein
IXO651_009455	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO651_009465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO651_009470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO651_009480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO651_009485	COG1546	Belongs to the CinA family
IXO651_009500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO651_009505	COG2137	regulation of response to DNA damage stimulus
IXO651_009510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO651_009515	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO651_009535	COG0305	Participates in initiation and elongation during chromosome replication
IXO651_009540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO651_009565	COG1741	Belongs to the pirin family
IXO651_009570	COG0583	DNA-binding transcription factor activity
IXO651_009600	COG0351	phosphomethylpyrimidine kinase
IXO651_009610	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO651_009615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO651_009630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO651_009640	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO651_009645	COG3734	2-keto-3-deoxy-galactonokinase
IXO651_009655	COG4948	Mandelate Racemase Muconate Lactonizing
IXO651_009660	COG0800	Aldolase
IXO651_009675	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO651_009685	COG1070	Carbohydrate kinase
IXO651_009695	COG0477	Major facilitator Superfamily
IXO651_009715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO651_009765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO651_009770	COG2258	MOSC domain
IXO651_009780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO651_009785	COG0505	Belongs to the CarA family
IXO651_009795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO651_009800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO651_009810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO651_009865	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IXO651_009875	COG0784	Response regulator, receiver
IXO651_009875	COG2198	Histidine kinase
IXO651_009875	COG2205	protein histidine kinase activity
IXO651_009880	COG1024	Enoyl-CoA hydratase
IXO651_009885	COG0318	PFAM AMP-dependent synthetase and ligase
IXO651_009915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO651_009970	COG0835	chemotaxis
IXO651_009985	COG0840	transmembrane signaling receptor activity
IXO651_009990	COG0840	transmembrane signaling receptor activity
IXO651_009995	COG0840	transmembrane signaling receptor activity
IXO651_010000	COG0840	transmembrane signaling receptor activity
IXO651_010010	COG0840	transmembrane signaling receptor activity
IXO651_010020	COG0840	transmembrane signaling receptor activity
IXO651_010030	COG0840	transmembrane signaling receptor activity
IXO651_010050	COG0745	RESPONSE REGULATOR receiver
IXO651_010060	COG0835	chemotaxis
IXO651_010070	COG1360	Flagellar Motor Protein
IXO651_010075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO651_010095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO651_010105	COG4771	TonB-dependent receptor
IXO651_010120	COG1192	Involved in chromosome partitioning
IXO651_010150	COG3039	Transposase
IXO651_010235	COG3039	Transposase
IXO651_010275	COG0343	queuine tRNA-ribosyltransferase activity
IXO651_010280	COG1862	Preprotein translocase
IXO651_010285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO651_010290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO651_010320	COG3328	transposase activity
IXO651_010335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO651_010345	COG0704	Plays a role in the regulation of phosphate uptake
IXO651_010360	COG0573	inorganic phosphate transmembrane transporter activity
IXO651_010365	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO651_010400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO651_010410	COG1024	Enoyl-CoA hydratase
IXO651_010420	COG0494	nUDIX hydrolase
IXO651_010465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO651_010465	COG0116	Belongs to the methyltransferase superfamily
IXO651_010490	COG0667	Aldo Keto reductase
IXO651_010500	COG2925	Exonuclease
IXO651_010535	COG0288	reversible hydration of carbon dioxide
IXO651_010565	COG0316	Belongs to the HesB IscA family
IXO651_010570	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO651_010580	COG0359	binds to the 23S rRNA
IXO651_010590	COG3115	cell septum assembly
IXO651_010610	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO651_010625	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO651_010650	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO651_010660	COG2986	histidine ammonia-lyase
IXO651_010665	COG1228	amidohydrolase
IXO651_010710	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO651_010720	COG1605	Chorismate mutase
IXO651_010720	COG0077	Prephenate dehydratase
IXO651_010725	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO651_010755	COG4566	intracellular signal transduction
IXO651_010800	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO651_010805	COG1469	GTP cyclohydrolase I activity
IXO651_010815	COG0617	tRNA 3'-terminal CCA addition
IXO651_010825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO651_010830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO651_010860	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO651_010875	COG4251	negative regulation of phosphorylation
IXO651_010875	COG3706	GGDEF domain
IXO651_010875	COG5001	Diguanylate cyclase
IXO651_010875	COG2203	Gaf domain
IXO651_010960	COG0386	Belongs to the glutathione peroxidase family
IXO651_011050	COG1247	-acetyltransferase
IXO651_011070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IXO651_011095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO651_011110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO651_011115	COG1393	Belongs to the ArsC family
IXO651_011120	COG0431	NADPH-dependent FMN reductase
IXO651_011125	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IXO651_011130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO651_011155	COG5002	protein histidine kinase activity
IXO651_011155	COG2205	protein histidine kinase activity
IXO651_011155	COG0784	Response regulator, receiver
IXO651_011195	COG0800	Aldolase
IXO651_011200	COG0129	dihydroxy-acid dehydratase activity
IXO651_011205	COG0363	glucosamine-6-phosphate deaminase activity
IXO651_011215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO651_011230	COG0354	folic acid binding
IXO651_011245	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO651_011260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO651_011275	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO651_011300	COG0811	peptide transport
IXO651_011315	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO651_011325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO651_011335	COG0322	excinuclease ABC activity
IXO651_011385	COG2801	Transposase and inactivated derivatives
IXO651_011395	COG2201	protein-glutamate methylesterase activity
IXO651_011445	COG0653	protein targeting
IXO651_011535	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO651_011535	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO651_011545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO651_011555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO651_011555	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO651_011570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO651_011600	COG0124	histidyl-tRNA synthetase
IXO651_011615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO651_011660	COG1012	belongs to the aldehyde dehydrogenase family
IXO651_011685	COG0697	spore germination
IXO651_011690	COG1794	racemase activity, acting on amino acids and derivatives
IXO651_011710	COG0671	phosphoesterase, PA-phosphatase related
IXO651_011725	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO651_011740	COG2183	response to ionizing radiation
IXO651_011750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO651_011750	COG0723	plastoquinol--plastocyanin reductase activity
IXO651_011765	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO651_011775	COG1183	phosphatidylcholine synthase activity
IXO651_011780	COG1028	Short-chain dehydrogenase reductase Sdr
IXO651_011805	COG0668	transmembrane transport
IXO651_011825	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO651_011855	COG1028	Short-chain dehydrogenase reductase Sdr
IXO651_011870	COG0583	DNA-binding transcription factor activity
IXO651_011875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO651_011880	COG3002	Belongs to the UPF0753 family
IXO651_011895	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO651_011925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO651_011935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO651_011940	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO651_011950	COG0776	regulation of translation
IXO651_011955	COG0539	negative regulation of cytoplasmic translation
IXO651_011960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO651_011975	COG2957	Belongs to the agmatine deiminase family
IXO651_011985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO651_012010	COG0395	ABC-type sugar transport system, permease component
IXO651_012015	COG1175	transmembrane transport
IXO651_012045	COG2350	Protein conserved in bacteria
IXO651_012050	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO651_012055	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO651_012060	COG1187	pseudouridine synthase activity
IXO651_012085	COG0436	Aminotransferase
IXO651_012090	COG4133	protoheme IX ABC transporter activity
IXO651_012150	COG0277	FAD linked oxidase domain protein
IXO651_012155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO651_012165	COG0531	amino acid
IXO651_012170	COG0531	amino acid
IXO651_012180	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO651_012210	COG3039	Transposase
IXO651_012220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO651_012295	COG0303	'Molybdopterin
IXO651_012305	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO651_012325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO651_012340	COG1024	Enoyl-CoA hydratase
IXO651_012340	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO651_012345	COG0183	Belongs to the thiolase family
IXO651_012355	COG0038	chloride channel
IXO651_012375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO651_012395	COG1674	ftsk spoiiie
IXO651_012400	COG0492	ferredoxin-NADP+ reductase activity
IXO651_012425	COG0542	response to heat
IXO651_012440	COG0482	sulfurtransferase activity
IXO651_012465	COG5001	Diguanylate cyclase
IXO651_012470	COG4585	Histidine kinase
IXO651_012480	COG5002	protein histidine kinase activity
IXO651_012500	COG0835	chemotaxis
IXO651_012500	COG0784	Response regulator, receiver
IXO651_012510	COG1558	bacterial-type flagellum-dependent cell motility
IXO651_012515	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO651_012525	COG4787	bacterial-type flagellum-dependent cell motility
IXO651_012560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO651_012565	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO651_012595	COG2201	protein-glutamate methylesterase activity
IXO651_012615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO651_012625	COG1028	Short-chain dehydrogenase reductase Sdr
IXO651_012655	COG1677	Flagellar hook-basal body complex protein FliE
IXO651_012705	COG3190	flagellar
IXO651_012720	COG1684	flagellar biosynthetic protein fliR
IXO651_012775	COG0643	Histidine kinase
IXO651_012775	COG0784	Response regulator, receiver
IXO651_012775	COG2198	Histidine kinase
IXO651_012800	COG3039	Transposase
IXO651_012810	COG3209	COG3209 Rhs family protein
IXO651_012905	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO651_012910	COG4988	ABC transporter
IXO651_012955	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO651_012975	COG0165	Argininosuccinate lyase
IXO651_012990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO651_012995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO651_013005	COG0137	argininosuccinate synthase activity
IXO651_013010	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO651_013025	COG2166	iron-sulfur cluster assembly
IXO651_013050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO651_013080	COG3039	Transposase
IXO651_013100	COG4677	pectinesterase activity
IXO651_013125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO651_013130	COG0402	S-adenosylhomocysteine deaminase activity
IXO651_013145	COG1509	lysine 2,3-aminomutase activity
IXO651_013150	COG3300	MHYT domain
IXO651_013150	COG5001	Diguanylate cyclase
IXO651_013165	COG0483	inositol monophosphate 1-phosphatase activity
IXO651_013170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO651_013190	COG0488	(ABC) transporter
IXO651_013195	COG0513	Belongs to the DEAD box helicase family
IXO651_013200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO651_013215	COG0625	glutathione transferase activity
IXO651_013220	COG1278	Cold shock
IXO651_013225	COG1671	Belongs to the UPF0178 family
IXO651_013230	COG4681	YaeQ
IXO651_013235	COG2081	HI0933 family
IXO651_013245	COG0501	Belongs to the peptidase M48B family
IXO651_013255	COG1028	Short-chain dehydrogenase reductase Sdr
IXO651_013275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO651_013280	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO651_013285	COG0802	atpase or kinase
IXO651_013290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO651_013290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO651_013295	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO651_013300	COG1570	exodeoxyribonuclease VII activity
IXO651_013315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO651_013395	COG3328	transposase activity
IXO651_013430	COG2969	positive regulation of protein catabolic process
IXO651_013435	COG0625	glutathione transferase activity
IXO651_013440	COG2857	Cytochrome c1
IXO651_013445	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO651_013450	COG0723	plastoquinol--plastocyanin reductase activity
IXO651_013455	COG0741	lytic transglycosylase activity
IXO651_013480	COG1702	phosphate starvation-inducible protein PhoH
IXO651_013500	COG4535	Mg2 and Co2 transporter CorC
IXO651_013515	COG1012	belongs to the aldehyde dehydrogenase family
IXO651_013525	COG1177	transmembrane transport
IXO651_013535	COG3842	ATPase activity
IXO651_013570	COG0174	glutamine synthetase
IXO651_013575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO651_013585	COG0477	Major facilitator Superfamily
IXO651_013595	COG0243	molybdopterin cofactor binding
IXO651_013605	COG2223	nitrite transmembrane transporter activity
IXO651_013610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO651_013615	COG1121	(ABC) transporter
IXO651_013625	COG2733	membrane
IXO651_013630	COG5002	protein histidine kinase activity
IXO651_013630	COG2205	protein histidine kinase activity
IXO651_013630	COG0784	Response regulator, receiver
IXO651_013640	COG3039	Transposase
IXO651_013645	COG2902	Dehydrogenase
IXO651_013655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO651_013660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO651_013680	COG1609	Transcriptional regulator
IXO651_013685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO651_013685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO651_013690	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO651_013695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO651_013695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO651_013710	COG3039	Transposase
IXO651_013720	COG3039	Transposase
IXO651_013860	COG0405	Gamma-glutamyltransferase
IXO651_013865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO651_013875	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO651_013880	COG0742	ribosomal rna small subunit methyltransferase
IXO651_013950	COG0583	DNA-binding transcription factor activity
IXO651_013960	COG3039	Transposase
IXO651_014040	COG1278	Cold shock
IXO651_014085	COG3039	Transposase
IXO651_014095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO651_014110	COG0557	exoribonuclease II activity
IXO651_014135	COG1960	acyl-CoA dehydrogenase activity
IXO651_014140	COG2226	methyltransferase
IXO651_014145	COG1410	methionine synthase
IXO651_014145	COG0646	methionine synthase
IXO651_014150	COG1410	methionine synthase
IXO651_014150	COG0646	methionine synthase
IXO651_014160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO651_014170	COG1609	Transcriptional regulator
IXO651_014185	COG2900	Belongs to the SlyX family
IXO651_014200	COG0386	Belongs to the glutathione peroxidase family
IXO651_014210	COG1725	Transcriptional regulator
IXO651_014215	COG1131	(ABC) transporter
IXO651_014290	COG2850	peptidyl-arginine hydroxylation
IXO651_014325	COG1132	(ABC) transporter
IXO651_014340	COG0583	DNA-binding transcription factor activity
IXO651_014355	COG0287	Prephenate dehydrogenase
IXO651_014355	COG1605	Chorismate mutase
IXO651_014360	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO651_014365	COG0484	heat shock protein binding
IXO651_014375	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO651_014385	COG0497	DNA recombination
IXO651_014395	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO651_014400	COG2914	Belongs to the UPF0125 (RnfH) family
IXO651_014410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO651_014425	COG1960	acyl-CoA dehydrogenase activity
IXO651_014435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO651_014480	COG2814	Major facilitator Superfamily
IXO651_014485	COG1566	PFAM secretion protein HlyD family protein
IXO651_014500	COG2207	Transcriptional regulator
IXO651_014525	COG4774	siderophore transport
IXO651_014535	COG0367	asparagine synthase
IXO651_014550	COG1393	Belongs to the ArsC family
IXO651_014610	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO651_014625	COG0233	cytoplasmic translational termination
IXO651_014635	COG0575	Belongs to the CDS family
IXO651_014645	COG0750	zinc metalloprotease
IXO651_014665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO651_014670	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO651_014690	COG0825	malonyl-CoA metabolic process
IXO651_014700	COG4771	TonB-dependent receptor
IXO651_014705	COG1131	(ABC) transporter
IXO651_014735	COG1981	membrane
IXO651_014780	COG0529	Catalyzes the synthesis of activated sulfate
IXO651_014780	COG2895	sulfate adenylyltransferase (ATP) activity
IXO651_014815	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO651_014830	COG2040	homocysteine
IXO651_014835	COG0833	amino acid
IXO651_014855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO651_014855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO651_014865	COG2878	Part of a membrane complex involved in electron transport
IXO651_014880	COG1595	DNA-templated transcription, initiation
IXO651_014905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO651_014920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO651_014925	COG0251	oxidation-reduction process
IXO651_014935	COG0392	lysyltransferase activity
IXO651_014935	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO651_014970	COG2814	Major facilitator Superfamily
IXO651_014975	COG1902	pentaerythritol trinitrate reductase activity
IXO651_014985	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO651_015000	COG1047	Peptidyl-prolyl cis-trans
IXO651_015050	COG3039	Transposase
IXO651_015055	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO651_015060	COG3039	Transposase
IXO651_015075	COG1451	nucleotide metabolic process
IXO651_015095	COG0183	Belongs to the thiolase family
IXO651_015125	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO651_015125	COG1793	dna ligase
IXO651_015135	COG1793	dna ligase
IXO651_015140	COG1201	RNA secondary structure unwinding
IXO651_015160	COG1278	Cold shock
IXO651_015165	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO651_015170	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO651_015180	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO651_015185	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IXO651_015190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO651_015215	COG2954	triphosphatase activity
IXO651_015230	COG1381	Involved in DNA repair and RecF pathway recombination
IXO651_015260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO651_015275	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO651_015275	COG1024	Enoyl-CoA hydratase
IXO651_015295	COG1024	Enoyl-CoA hydratase
IXO651_015300	COG1960	acyl-CoA dehydrogenase activity
IXO651_015370	COG2353	YceI-like domain
IXO651_015380	COG2353	YceI-like domain
IXO651_015395	COG1760	l-serine dehydratase
IXO651_015405	COG0626	cystathionine gamma-synthase activity
IXO651_015410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO651_015415	COG0739	heme binding
IXO651_015420	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IXO651_015425	COG1272	protein, Hemolysin III
IXO651_015445	COG0463	Glycosyl transferase, family 2
IXO651_015455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO651_015465	COG4771	TonB-dependent receptor
IXO651_015470	COG1309	transcriptional regulator
IXO651_015480	COG1960	acyl-CoA dehydrogenase activity
IXO651_015515	COG0509	glycine decarboxylation via glycine cleavage system
IXO651_015530	COG0330	HflC and HflK could
IXO651_015545	COG3956	TIGRFAM MazG family protein
IXO651_015555	COG0494	nUDIX hydrolase
IXO651_015565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO651_015570	COG0837	glucose binding
IXO651_015585	COG1388	LysM domain
IXO651_015585	COG3858	chitin binding
IXO651_015595	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO651_015605	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO651_015675	COG3537	Alpha-1,2-mannosidase
IXO651_015720	COG1446	asparaginase
IXO651_015760	COG0784	Response regulator, receiver
IXO651_015760	COG0643	Histidine kinase
IXO651_015760	COG2198	Histidine kinase
IXO651_015765	COG0840	transmembrane signaling receptor activity
IXO651_015770	COG0835	chemotaxis
IXO651_015785	COG0189	ligase activity
IXO651_015795	COG1397	ADP-ribosylglycohydrolase
IXO651_015805	COG1199	ATP-dependent helicase activity
IXO651_015815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO651_015820	COG1215	transferase activity, transferring glycosyl groups
IXO651_015830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO651_015845	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IXO651_015850	COG0535	radical SAM domain protein
IXO651_015855	COG0535	radical SAM domain protein
IXO651_015890	COG1643	Atp-dependent helicase
IXO651_015895	COG0783	Belongs to the Dps family
IXO651_015900	COG0514	ATP-dependent DNA helicase (RecQ)
IXO651_015920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO651_015945	COG0602	queuosine metabolic process
IXO651_015955	COG2885	chlorophyll binding
IXO651_015960	COG0823	Involved in the tonB-independent uptake of proteins
IXO651_015970	COG0848	biopolymer transport protein
IXO651_015980	COG0824	Thioesterase
IXO651_015985	COG2255	four-way junction helicase activity
IXO651_015995	COG0632	four-way junction helicase activity
IXO651_016175	COG2022	thiamine diphosphate biosynthetic process
IXO651_016185	COG0471	metal ion transport
IXO651_016185	COG3273	potassium ion transport
IXO651_016215	COG1970	mechanosensitive ion channel activity
IXO651_016250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO651_016275	COG0308	aminopeptidase N
IXO651_016280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO651_016290	COG2895	sulfate adenylyltransferase (ATP) activity
IXO651_016290	COG0529	Catalyzes the synthesis of activated sulfate
IXO651_016295	COG0175	sulfate reduction
IXO651_016300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO651_016305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO651_016310	COG0175	sulfate reduction
IXO651_016330	COG2205	protein histidine kinase activity
IXO651_016330	COG2198	Histidine kinase
IXO651_016330	COG0784	Response regulator, receiver
IXO651_016375	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO651_016380	COG3588	fructose-bisphosphate aldolase
IXO651_016385	COG0469	pyruvate kinase activity
IXO651_016395	COG0126	phosphoglycerate kinase activity
IXO651_016425	COG0753	catalase activity
IXO651_016450	COG2207	Transcriptional regulator
IXO651_016450	COG1917	Cupin 2, conserved barrel domain protein
IXO651_016470	COG0823	Involved in the tonB-independent uptake of proteins
IXO651_016470	COG1506	peptidase
IXO651_016490	COG1297	OPT oligopeptide transporter protein
IXO651_016505	COG0587	DNA-directed DNA polymerase activity
IXO651_016575	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO651_016590	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO651_016595	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO651_016600	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO651_016620	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO651_016635	COG0732	type I restriction modification DNA specificity domain
IXO651_016800	COG3179	chitinase
IXO651_016830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO651_016840	COG0412	Dienelactone hydrolase
IXO651_016860	COG0717	Belongs to the dCTP deaminase family
IXO651_016865	COG0489	protein tyrosine kinase activity
IXO651_016905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO651_016910	COG2311	Membrane
IXO651_016915	COG1047	Peptidyl-prolyl cis-trans
IXO651_016920	COG0791	NLP P60 protein
IXO651_016925	COG0791	NLP P60 protein
IXO651_016940	COG3039	Transposase
IXO651_016950	COG1301	dicarboxylic acid transport
IXO651_016955	COG1785	Belongs to the alkaline phosphatase family
IXO651_016960	COG0037	tRNA processing
IXO651_016965	COG1722	exodeoxyribonuclease VII activity
IXO651_016970	COG0142	geranyltranstransferase activity
IXO651_016995	COG0312	modulator of DNA gyrase
IXO651_017000	COG3028	Belongs to the UPF0307 family
IXO651_017005	COG0312	modulator of DNA gyrase
IXO651_017015	COG3164	Protein of unknown function
IXO651_017030	COG2968	Membrane
IXO651_017060	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO651_017085	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO651_017110	COG3118	belongs to the thioredoxin family
IXO651_017165	COG3039	Transposase
IXO651_017190	COG3039	Transposase
IXO651_017215	COG3209	COG3209 Rhs family protein
IXO651_017220	COG3039	Transposase
IXO651_017240	COG3209	COG3209 Rhs family protein
IXO651_017250	COG3039	Transposase
IXO651_017285	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO651_017290	COG1845	cytochrome c oxidase, subunit III
IXO651_017295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO651_017310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO651_017315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO651_017325	COG0196	riboflavin kinase activity
IXO651_017330	COG0728	peptidoglycan biosynthetic process
IXO651_017335	COG0268	Binds directly to 16S ribosomal RNA
IXO651_017340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO651_017345	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO651_017355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO651_017360	COG0824	Thioesterase
IXO651_017375	COG1946	Acyl-CoA thioesterase
IXO651_017385	COG1595	DNA-templated transcription, initiation
IXO651_017400	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO651_017440	COG1877	trehalose-phosphatase activity
IXO651_017445	COG3387	PFAM Glycoside hydrolase 15-related
IXO651_017470	COG0564	pseudouridine synthase activity
IXO651_017475	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO651_017480	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO651_017480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO651_017490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO651_017495	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO651_017535	COG2194	sulfuric ester hydrolase activity
IXO651_017540	COG4969	Belongs to the N-Me-Phe pilin family
IXO651_017550	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO651_017585	COG3039	Transposase
IXO651_017600	COG3209	COG3209 Rhs family protein
IXO651_017615	COG3039	Transposase
IXO651_017630	COG3039	Transposase
IXO651_017665	COG1132	(ABC) transporter
IXO651_017695	COG0745	RESPONSE REGULATOR receiver
IXO651_017700	COG5000	phosphorelay sensor kinase activity
IXO651_017700	COG5002	protein histidine kinase activity
IXO651_017705	COG0475	glutathione-regulated potassium exporter activity
IXO651_017715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO651_017735	COG1187	pseudouridine synthase activity
IXO651_017740	COG5001	Diguanylate cyclase
IXO651_017740	COG5002	protein histidine kinase activity
IXO651_017855	COG1028	Short-chain dehydrogenase reductase Sdr
IXO651_017870	COG0415	Belongs to the DNA photolyase family
IXO651_017875	COG0305	Participates in initiation and elongation during chromosome replication
IXO651_017885	COG0367	asparagine synthase
IXO651_017900	COG1960	acyl-CoA dehydrogenase activity
IXO651_017915	COG0084	hydrolase, TatD family'
IXO651_017920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO651_017980	COG0735	belongs to the Fur family
IXO651_017985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO651_018035	COG3039	Transposase
IXO651_018070	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO651_018080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO651_018095	COG0643	Histidine kinase
IXO651_018095	COG2198	Histidine kinase
IXO651_018100	COG0840	transmembrane signaling receptor activity
IXO651_018105	COG0835	chemotaxis
IXO651_018110	COG2202	Pas domain
IXO651_018110	COG2200	EAL domain
IXO651_018110	COG2199	diguanylate cyclase activity
IXO651_018115	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO651_018130	COG3590	peptidase
IXO651_018145	COG0588	phosphoglycerate mutase activity
IXO651_018150	COG1515	deoxyribonuclease V activity
IXO651_018160	COG1741	Belongs to the pirin family
IXO651_018220	COG3039	Transposase
IXO651_018325	COG2963	transposase activity
IXO651_018355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO651_018370	COG2197	response regulator
IXO651_018375	COG4585	Histidine kinase
IXO651_018395	COG2894	cell division
IXO651_018400	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO651_018410	COG0642	Histidine kinase
IXO651_018415	COG0745	RESPONSE REGULATOR receiver
IXO651_018420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO651_018430	COG2194	sulfuric ester hydrolase activity
IXO651_018460	COG3551	Protein conserved in bacteria
IXO651_018520	COG0203	ribosomal protein L17
IXO651_018530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO651_018535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO651_018545	COG0201	protein transport
IXO651_018555	COG1841	ribosomal large subunit assembly
IXO651_018565	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IXO651_018585	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO651_018590	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IXO651_018595	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO651_018600	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO651_018605	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO651_018610	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO651_018620	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO651_018635	COG0089	rRNA binding
IXO651_018640	COG0088	Forms part of the polypeptide exit tunnel
IXO651_018645	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO651_018650	COG0051	transcription antitermination factor activity, RNA binding
IXO651_018670	COG0049	tRNA binding
IXO651_018675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO651_018680	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO651_018685	COG0085	RNA polymerase activity
IXO651_018690	COG0222	ribosome binding
IXO651_018695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO651_018705	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO651_018710	COG0250	Participates in transcription elongation, termination and antitermination
IXO651_018715	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO651_018745	COG0012	GTP binding
IXO651_018750	COG0193	aminoacyl-tRNA hydrolase activity
IXO651_018760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO651_018775	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO651_018785	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO651_018790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO651_018800	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO651_018820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO651_018825	COG1295	ribonuclease BN
IXO651_018855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO651_018860	COG1404	Belongs to the peptidase S8 family
IXO651_018865	COG1404	Belongs to the peptidase S8 family
IXO651_018875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO651_018900	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO651_018925	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO651_018940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO651_018940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO651_018985	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO651_018995	COG3634	alkyl hydroperoxide reductase activity
IXO651_019000	COG0583	DNA-binding transcription factor activity
IXO651_019005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO651_019010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO651_019055	COG2197	response regulator
IXO651_019165	COG3386	PFAM SMP-30 Gluconolaconase
IXO651_019185	COG1024	Enoyl-CoA hydratase
IXO651_019195	COG0318	PFAM AMP-dependent synthetase and ligase
IXO651_019200	COG0583	DNA-binding transcription factor activity
IXO651_019240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO651_019245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO651_019255	COG2096	Adenosyltransferase
IXO651_019260	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO651_019275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO651_019285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO651_019290	COG2967	ApaG domain
IXO651_019295	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IXO651_019315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO651_019335	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO651_019360	COG0642	Histidine kinase
IXO651_019375	COG4181	ATPase activity
IXO651_019385	COG2175	clavaminate synthase activity
IXO651_019435	COG0667	Aldo Keto reductase
IXO651_019445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO651_019450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO651_019460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO651_019475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO651_019510	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO651_019515	COG2226	methyltransferase
IXO651_019560	COG0604	alcohol dehydrogenase
IXO651_019560	COG3321	synthase
IXO651_019560	COG1028	Short-chain dehydrogenase reductase Sdr
IXO651_019570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO651_019585	COG0494	nUDIX hydrolase
IXO651_019595	COG0653	protein targeting
IXO651_019600	COG4942	peptidase
IXO651_019600	COG1388	LysM domain
IXO651_019610	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO651_019625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO651_019630	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO651_019635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO651_019650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO651_019655	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO651_019670	COG3116	cell division
IXO651_019675	COG0275	rRNA processing
IXO651_019710	COG0792	nuclease activity
IXO651_019715	COG1988	membrane-bound metal-dependent
IXO651_019720	COG0277	FAD linked oxidase domain protein
IXO651_019725	COG0745	RESPONSE REGULATOR receiver
IXO651_019730	COG2205	protein histidine kinase activity
IXO651_019740	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO651_019745	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO651_019765	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO651_019770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO651_019775	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO651_019795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO651_019795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO651_019815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO651_019835	COG0488	(ABC) transporter
IXO651_019885	COG2205	protein histidine kinase activity
IXO651_019920	COG2205	protein histidine kinase activity
IXO651_019935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO651_019980	COG3039	Transposase
IXO651_019985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO651_020085	COG1649	PFAM Uncharacterised BCR, COG1649
IXO651_020085	COG0726	polysaccharide deacetylase
IXO651_020090	COG1215	transferase activity, transferring glycosyl groups
IXO651_020100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO651_020105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO651_020110	COG1609	Transcriptional regulator
IXO651_020120	COG2188	Transcriptional regulator
IXO651_020135	COG3250	beta-galactosidase activity
IXO651_020185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO651_020190	COG4191	Histidine kinase
IXO651_020195	COG0784	Response regulator, receiver
IXO651_020200	COG4251	negative regulation of phosphorylation
IXO651_020205	COG2823	Periplasmic or secreted lipoprotein
IXO651_020210	COG0673	inositol 2-dehydrogenase activity
IXO651_020215	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO651_020250	COG1051	belongs to the nudix hydrolase family
IXO651_020250	COG1056	cytidyltransferase-related domain
IXO651_020275	COG2921	Belongs to the UPF0250 family
IXO651_020285	COG1686	Belongs to the peptidase S11 family
IXO651_020290	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO651_020295	COG2951	lytic endotransglycosylase activity
IXO651_020330	COG3039	Transposase
IXO651_020360	COG0772	Belongs to the SEDS family
IXO651_020375	COG1792	Involved in formation and maintenance of cell shape
IXO651_020380	COG1077	Cell shape determining protein MreB Mrl
IXO651_020385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO651_020435	COG2199	diguanylate cyclase activity
IXO651_020440	COG0308	aminopeptidase N
IXO651_020470	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO651_020500	COG0436	Aminotransferase
IXO651_020515	COG1505	serine-type exopeptidase activity
IXO651_020540	COG0181	hydroxymethylbilane synthase activity
IXO651_020550	COG3275	phosphorelay sensor kinase activity
IXO651_020595	COG0659	secondary active sulfate transmembrane transporter activity
IXO651_020600	COG5297	Belongs to the glycosyl hydrolase family 6
IXO651_020600	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO651_020610	COG0840	transmembrane signaling receptor activity
IXO651_020665	COG3039	Transposase
IXO651_020685	COG0598	Magnesium transport protein CorA
IXO651_020695	COG1113	amino acid transport
IXO651_020705	COG5297	Belongs to the glycosyl hydrolase family 6
IXO651_020710	COG4305	rare lipoprotein A
IXO651_020715	COG0697	spore germination
IXO651_020775	COG4221	oxidoreductase activity
IXO651_020805	COG0456	acetyltransferase
IXO651_020815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO651_020865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO651_020865	COG2111	Na H antiporter
IXO651_020870	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO651_020875	COG0651	ATP synthesis coupled electron transport
IXO651_020885	COG2212	antiporter activity
IXO651_020890	COG1320	monovalent cation:proton antiporter activity
IXO651_020900	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO651_020920	COG3104	oligopeptide transport
IXO651_020925	COG3483	tryptophan 2,3-dioxygenase activity
IXO651_020935	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IXO651_020970	COG0183	Belongs to the thiolase family
IXO651_021015	COG3039	Transposase
IXO651_021080	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO651_021085	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO651_021095	COG4948	Mandelate Racemase Muconate Lactonizing
IXO651_021120	COG0531	amino acid
IXO651_021145	COG4682	membrane
IXO651_021150	COG2133	pyrroloquinoline quinone binding
IXO651_021205	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO651_021210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO651_021220	COG1610	YqeY-like protein
IXO651_021235	COG1295	ribonuclease BN
IXO651_021240	COG0358	DNA primase activity
IXO651_021285	COG3039	Transposase
IXO651_021340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO651_021350	COG1560	Kdo2-lipid A biosynthetic process
IXO651_021400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO651_021400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO651_021405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO651_021410	COG0242	peptide deformylase activity
IXO651_021415	COG1652	LysM domain
IXO651_021420	COG0758	DNA mediated transformation
IXO651_021425	COG2922	Belongs to the Smg family
IXO651_021440	COG1754	DNA topoisomerase type I activity
IXO651_021440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO651_021445	COG0009	L-threonylcarbamoyladenylate synthase
IXO651_021460	COG1028	Short-chain dehydrogenase reductase Sdr
IXO651_021470	COG0616	signal peptide processing
IXO651_021475	COG0534	Mate efflux family protein
IXO651_021495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO651_021530	COG1324	tolerance protein
IXO651_021540	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO651_021545	COG0511	ligase activity, forming carbon-carbon bonds
IXO651_021555	COG0439	Biotin carboxylase
IXO651_021600	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO651_021640	COG3210	domain, Protein
IXO651_021670	COG3210	domain, Protein
IXO651_021675	COG2831	hemolysin activation secretion protein
IXO651_021705	COG2267	carboxylic ester hydrolase activity
IXO651_021710	COG2267	carboxylic ester hydrolase activity
IXO651_021725	COG0419	ATPase involved in DNA repair
IXO651_021735	COG0151	Belongs to the GarS family
IXO651_021755	COG1289	transmembrane transporter activity
IXO651_021770	COG2814	Major facilitator Superfamily
IXO651_021785	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO651_021820	COG0745	RESPONSE REGULATOR receiver
IXO651_021865	COG0739	heme binding
IXO651_021880	COG2211	Major facilitator Superfamily
IXO651_021885	COG0708	Exodeoxyribonuclease III
IXO651_021900	COG1192	Involved in chromosome partitioning
IXO651_021905	COG1475	DNA binding
IXO651_021920	COG0463	Glycosyl transferase, family 2
IXO651_021945	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO651_021970	COG4221	oxidoreductase activity
IXO651_021995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO651_022000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO651_022015	COG3485	protocatechuate 3,4-dioxygenase
IXO651_022020	COG3485	protocatechuate 3,4-dioxygenase
IXO651_022060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO651_022065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO651_022075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO651_022075	COG1042	CoA-binding domain protein
IXO651_022075	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO651_022085	COG2239	Acts as a magnesium transporter
IXO651_022100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO651_022105	COG3387	PFAM Glycoside hydrolase 15-related
IXO651_022120	COG3100	YcgL domain-containing protein
IXO651_022125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO651_022135	COG0463	Glycosyl transferase, family 2
IXO651_022150	COG1028	Short-chain dehydrogenase reductase Sdr
IXO651_022160	COG0156	8-amino-7-oxononanoate synthase activity
IXO651_022165	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO651_022170	COG1040	competence protein
IXO651_022175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO651_022185	COG0628	permease
IXO651_022195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO651_022205	COG1595	DNA-templated transcription, initiation
IXO651_022210	COG0753	catalase activity
IXO651_022260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO651_022265	COG0180	Tryptophanyl-tRNA synthetase
IXO651_022270	COG3237	CsbD-like
IXO651_022305	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO651_022320	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO651_022325	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO651_022325	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO651_022365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO651_022385	COG1566	PFAM secretion protein HlyD family protein
IXO651_022400	COG1199	ATP-dependent helicase activity
IXO651_022440	COG0583	DNA-binding transcription factor activity
IXO651_022485	COG0625	glutathione transferase activity
IXO651_022520	COG4555	ABC transporter
IXO651_022530	COG1476	TRANSCRIPTIONal
IXO651_022560	COG1131	(ABC) transporter
IXO651_022565	COG0842	Transport permease protein
IXO651_022665	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO651_022675	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO651_022685	COG0564	pseudouridine synthase activity
IXO651_022710	COG0339	signal peptide processing
IXO651_022740	COG3254	rhamnose metabolic process
IXO651_022745	COG0738	Major facilitator superfamily
IXO651_022750	COG1414	Transcriptional regulator
IXO651_022765	COG2205	protein histidine kinase activity
IXO651_022775	COG3459	Glycosyltransferase 36 associated
IXO651_022780	COG2211	Major facilitator Superfamily
IXO651_022785	COG3265	gluconokinase activity
IXO651_022790	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO651_022830	COG3039	Transposase
IXO651_022890	COG1127	ABC transporter
IXO651_022895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO651_022900	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO651_022915	COG2853	Lipoprotein
IXO651_022940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO651_023005	COG0676	glucose-6-phosphate 1-epimerase activity
IXO651_023025	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO651_023035	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO651_023045	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO651_023050	COG1064	alcohol dehydrogenase
IXO651_023100	COG1522	sequence-specific DNA binding
IXO651_023105	COG3186	Phenylalanine-4-hydroxylase
IXO651_023145	COG0656	L-ascorbic acid biosynthetic process
IXO651_023150	COG2130	NADP-dependent
IXO651_023155	COG0667	Aldo Keto reductase
IXO651_023165	COG1187	pseudouridine synthase activity
IXO651_023175	COG1643	Atp-dependent helicase
IXO651_023180	COG4807	Protein conserved in bacteria
IXO651_023185	COG4948	Mandelate Racemase Muconate Lactonizing
IXO651_023190	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO651_023195	COG1028	Short-chain dehydrogenase reductase Sdr
IXO651_023215	COG3507	Belongs to the glycosyl hydrolase 43 family
IXO651_023255	COG3162	membrane
IXO651_023260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO651_023275	COG0708	Exodeoxyribonuclease III
IXO651_023290	COG2091	lysine biosynthetic process via aminoadipic acid
IXO651_023300	COG3540	Alkaline phosphatase
IXO651_023305	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO651_023330	COG2159	amidohydrolase
IXO651_023340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO651_023345	COG0583	DNA-binding transcription factor activity
IXO651_023350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO651_023365	COG0210	DNA helicase
IXO651_023385	COG0531	amino acid
IXO651_023395	COG1322	Protein conserved in bacteria
IXO651_023405	COG0386	Belongs to the glutathione peroxidase family
IXO651_023455	COG0793	Belongs to the peptidase S41A family
IXO651_023460	COG4942	peptidase
IXO651_023470	COG2234	aminopeptidase activity
IXO651_023515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO651_023520	COG0302	gtp cyclohydrolase
IXO651_023540	COG0477	Major facilitator Superfamily
IXO651_023555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO651_023620	COG1192	Involved in chromosome partitioning
IXO651_023650	COG1929	Belongs to the glycerate kinase type-1 family
IXO651_023655	COG2271	Major facilitator Superfamily
IXO651_023670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO651_023675	COG0861	Integral membrane protein TerC family
IXO651_023685	COG0584	glycerophosphoryl diester phosphodiesterase
IXO651_023695	COG0671	phosphoesterase, PA-phosphatase related
IXO651_023700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IXO651_023720	COG0706	membrane insertase activity