locus-tag	class	description
IXO675_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO675_000020	COG0187	DNA topoisomerase II activity
IXO675_000030	COG0501	Belongs to the peptidase M48B family
IXO675_000060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO675_000070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO675_000080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO675_000090	COG4772	TonB-dependent receptor
IXO675_000105	COG3039	Transposase
IXO675_000110	COG1304	FMN binding
IXO675_000130	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO675_000140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO675_000150	COG3039	Transposase
IXO675_000235	COG2826	transposase and inactivated derivatives, IS30 family
IXO675_000260	COG3039	Transposase
IXO675_000270	COG1090	epimerase
IXO675_000280	COG0642	Histidine kinase
IXO675_000290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO675_000400	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO675_000475	COG3264	Mechanosensitive ion channel
IXO675_000475	COG1511	domain protein
IXO675_000490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO675_000495	COG2354	Protein conserved in bacteria
IXO675_000500	COG1649	PFAM Uncharacterised BCR, COG1649
IXO675_000520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO675_000545	COG0702	epimerase
IXO675_000560	COG1858	cytochrome C peroxidase
IXO675_000635	COG0513	Belongs to the DEAD box helicase family
IXO675_000640	COG3039	Transposase
IXO675_000680	COG1136	(ABC) transporter
IXO675_000730	COG1136	(ABC) transporter
IXO675_000760	COG3039	Transposase
IXO675_000775	COG1272	protein, Hemolysin III
IXO675_000780	COG1111	helicase
IXO675_000780	COG1205	dead DEAH box helicase
IXO675_000840	COG0070	glutamate synthase
IXO675_000840	COG0067	glutamate synthase
IXO675_000840	COG0069	glutamate synthase activity
IXO675_000845	COG0493	'glutamate synthase
IXO675_000895	COG1609	Transcriptional regulator
IXO675_000925	COG0366	Alpha amylase catalytic
IXO675_000930	COG0366	Alpha amylase catalytic
IXO675_000990	COG0606	chelatase, subunit chli
IXO675_001035	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO675_001040	COG1166	arginine decarboxylase activity
IXO675_001090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO675_001115	COG1028	Short-chain dehydrogenase reductase Sdr
IXO675_001140	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO675_001155	COG0210	DNA helicase
IXO675_001170	COG3132	Protein of unknown function, DUF480
IXO675_001175	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO675_001180	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO675_001215	COG2937	Belongs to the GPAT DAPAT family
IXO675_001255	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO675_001265	COG1119	ATPase activity
IXO675_001280	COG1125	glycine betaine transport
IXO675_001280	COG0517	IMP dehydrogenase activity
IXO675_001295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO675_001300	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO675_001305	COG3550	peptidyl-serine autophosphorylation
IXO675_001310	COG1396	sequence-specific DNA binding
IXO675_001335	COG0489	protein tyrosine kinase activity
IXO675_001340	COG2062	phosphohistidine phosphatase, SixA
IXO675_001350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO675_001395	COG1968	undecaprenyl-diphosphatase activity
IXO675_001400	COG0174	glutamine synthetase
IXO675_001405	COG0347	Belongs to the P(II) protein family
IXO675_001410	COG0004	ammonium transporteR
IXO675_001415	COG3852	Histidine kinase
IXO675_001420	COG2204	response regulator
IXO675_001425	COG2032	superoxide dismutase activity
IXO675_001430	COG2032	superoxide dismutase activity
IXO675_001485	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO675_001490	COG1074	ATP-dependent DNA helicase activity
IXO675_001500	COG3549	Plasmid maintenance system killer
IXO675_001575	COG1764	response to oxidative stress
IXO675_001580	COG1846	Transcriptional regulator
IXO675_001625	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IXO675_001665	COG2211	Major facilitator Superfamily
IXO675_001685	COG3693	PFAM glycoside hydrolase, family 10
IXO675_001710	COG0246	Mannitol dehydrogenase
IXO675_001715	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO675_001725	COG4948	Mandelate Racemase Muconate Lactonizing
IXO675_001735	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO675_001750	COG0037	tRNA processing
IXO675_001755	COG2974	May be involved in recombination
IXO675_001780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO675_001790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO675_001800	COG0805	protein transport
IXO675_001810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO675_001810	COG0519	Catalyzes the synthesis of GMP from XMP
IXO675_001830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO675_001835	COG0752	glycyl-tRNA synthetase alpha subunit
IXO675_001845	COG0457	Tetratricopeptide repeat
IXO675_001850	COG4771	TonB-dependent receptor
IXO675_001865	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO675_001875	COG0697	spore germination
IXO675_001885	COG0523	cobalamin synthesis protein
IXO675_001935	COG1960	acyl-CoA dehydrogenase activity
IXO675_001940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO675_001945	COG4770	biotin carboxylase activity
IXO675_001995	COG2072	flavoprotein involved in K transport
IXO675_002015	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO675_002060	COG0084	hydrolase, TatD family'
IXO675_002075	COG0583	DNA-binding transcription factor activity
IXO675_002080	COG2814	Major facilitator Superfamily
IXO675_002090	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO675_002095	COG1902	pentaerythritol trinitrate reductase activity
IXO675_002125	COG0745	RESPONSE REGULATOR receiver
IXO675_002145	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO675_002150	COG0583	DNA-binding transcription factor activity
IXO675_002180	COG0702	epimerase
IXO675_002185	COG1733	regulation of RNA biosynthetic process
IXO675_002245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO675_002260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO675_002295	COG2911	Protein conserved in bacteria
IXO675_002300	COG0729	surface antigen
IXO675_002315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO675_002320	COG3118	belongs to the thioredoxin family
IXO675_002330	COG2884	Cell division ATP-binding protein ftsE
IXO675_002335	COG2177	Part of the ABC transporter FtsEX involved in
IXO675_002340	COG2201	protein-glutamate methylesterase activity
IXO675_002345	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO675_002350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO675_002360	COG1252	NADH dehydrogenase
IXO675_002385	COG0459	protein refolding
IXO675_002395	COG4771	TonB-dependent receptor
IXO675_002410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO675_002450	COG3386	PFAM SMP-30 Gluconolaconase
IXO675_002465	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO675_002495	COG2353	YceI-like domain
IXO675_002600	COG0408	coproporphyrinogen oxidase activity
IXO675_002610	COG3039	Transposase
IXO675_002635	COG0129	dihydroxy-acid dehydratase activity
IXO675_002645	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO675_002680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO675_002685	COG0318	PFAM AMP-dependent synthetase and ligase
IXO675_002690	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO675_002695	COG0596	Alpha beta hydrolase
IXO675_002710	COG3177	Filamentation induced by cAMP protein fic
IXO675_002715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO675_002730	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO675_002755	COG4191	Histidine kinase
IXO675_002760	COG0028	Belongs to the TPP enzyme family
IXO675_002775	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO675_002780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO675_002805	COG5383	Protein conserved in bacteria
IXO675_002815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO675_002820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO675_002825	COG1473	amidohydrolase
IXO675_002835	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO675_002835	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO675_002840	COG3328	transposase activity
IXO675_002900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO675_002915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO675_002920	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO675_002930	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO675_002935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO675_002940	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO675_002990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO675_003005	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO675_003070	COG3039	Transposase
IXO675_003100	COG1271	oxidase subunit
IXO675_003155	COG2972	Histidine kinase
IXO675_003170	COG0531	amino acid
IXO675_003190	COG3590	peptidase
IXO675_003205	COG0667	Aldo Keto reductase
IXO675_003220	COG3384	dioxygenase
IXO675_003230	COG1573	uracil-dna glycosylase
IXO675_003240	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO675_003255	COG0025	NhaP-type Na H and K H
IXO675_003260	COG1131	(ABC) transporter
IXO675_003265	COG0842	Transport permease protein
IXO675_003285	COG1404	Belongs to the peptidase S8 family
IXO675_003300	COG0745	RESPONSE REGULATOR receiver
IXO675_003350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO675_003375	COG2205	protein histidine kinase activity
IXO675_003375	COG2202	Pas domain
IXO675_003405	COG2813	Specifically methylates the guanine in position
IXO675_003410	COG1187	pseudouridine synthase activity
IXO675_003415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO675_003450	COG0697	spore germination
IXO675_003460	COG2011	ABC-type metal ion transport system permease component
IXO675_003490	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO675_003500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO675_003520	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO675_003530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO675_003540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO675_003545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO675_003550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO675_003605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO675_003610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO675_003660	COG0339	signal peptide processing
IXO675_003695	COG1956	GAF domain-containing protein
IXO675_003700	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO675_003710	COG0720	synthase
IXO675_003715	COG0513	Belongs to the DEAD box helicase family
IXO675_003725	COG0625	glutathione transferase activity
IXO675_003755	COG0626	cystathionine gamma-synthase activity
IXO675_003805	COG3328	transposase activity
IXO675_003830	COG2086	electron transfer activity
IXO675_003855	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO675_003855	COG0662	Cupin 2, conserved barrel domain protein
IXO675_003860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO675_003895	COG3218	ABC-type transport auxiliary lipoprotein component
IXO675_003895	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO675_003900	COG1127	ABC transporter
IXO675_003905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO675_003920	COG0442	prolyl-tRNA aminoacylation
IXO675_003930	COG1183	phosphatidylcholine synthase activity
IXO675_003960	COG3039	Transposase
IXO675_003985	COG3039	Transposase
IXO675_004025	COG0525	valine-tRNA ligase activity
IXO675_004040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO675_004050	COG0795	lipopolysaccharide-transporting ATPase activity
IXO675_004065	COG4974	Belongs to the 'phage' integrase family
IXO675_004070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO675_004080	COG5295	Hep Hag repeat protein
IXO675_004090	COG1404	Belongs to the peptidase S8 family
IXO675_004100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO675_004110	COG1459	type II secretion system
IXO675_004115	COG2165	general secretion pathway protein
IXO675_004120	COG4970	Tfp pilus assembly protein FimT
IXO675_004125	COG2165	general secretion pathway protein
IXO675_004130	COG4795	General secretion pathway protein
IXO675_004135	COG3156	type II secretion system protein K
IXO675_004140	COG3166	PFAM Fimbrial assembly family protein
IXO675_004155	COG1450	Type ii and iii secretion system protein
IXO675_004170	COG2188	Transcriptional regulator
IXO675_004220	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO675_004225	COG1518	maintenance of DNA repeat elements
IXO675_004270	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO675_004295	COG1028	Short-chain dehydrogenase reductase Sdr
IXO675_004300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO675_004310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO675_004315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO675_004345	COG3829	transcription factor binding
IXO675_004415	COG2826	transposase and inactivated derivatives, IS30 family
IXO675_004425	COG0678	peroxiredoxin activity
IXO675_004445	COG0330	HflC and HflK could
IXO675_004450	COG0330	HflC and HflK could
IXO675_004460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO675_004465	COG0308	aminopeptidase N
IXO675_004510	COG1560	Kdo2-lipid A biosynthetic process
IXO675_004515	COG1519	Transferase
IXO675_004520	COG1538	Outer membrane efflux protein
IXO675_004525	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO675_004555	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO675_004560	COG0066	3-isopropylmalate dehydratase activity
IXO675_004595	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO675_004605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO675_004635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO675_004655	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO675_004685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO675_004695	COG3781	membrane
IXO675_004830	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO675_004850	COG1217	gtp-binding protein TYPA
IXO675_004855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO675_004860	COG0039	L-malate dehydrogenase activity
IXO675_004865	COG0625	glutathione transferase activity
IXO675_004880	COG3039	Transposase
IXO675_004900	COG0584	glycerophosphoryl diester phosphodiesterase
IXO675_004940	COG1902	pentaerythritol trinitrate reductase activity
IXO675_004940	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO675_004945	COG0604	alcohol dehydrogenase
IXO675_004970	COG0156	8-amino-7-oxononanoate synthase activity
IXO675_004975	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO675_004980	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO675_004985	COG4208	sulfate ABC transporter
IXO675_004990	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO675_005020	COG0588	phosphoglycerate mutase activity
IXO675_005030	COG0285	dihydrofolate synthase activity
IXO675_005050	COG2833	Protein of unknown function (DUF455)
IXO675_005070	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO675_005075	COG0671	phosphoesterase, PA-phosphatase related
IXO675_005080	COG0438	transferase activity, transferring glycosyl groups
IXO675_005090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO675_005105	COG4783	chaperone-mediated protein folding
IXO675_005130	COG0473	3-isopropylmalate dehydrogenase activity
IXO675_005180	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO675_005220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO675_005245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO675_005255	COG0631	protein serine/threonine phosphatase activity
IXO675_005325	COG0582	viral genome integration into host DNA
IXO675_005335	COG0859	PFAM glycosyl transferase family 9
IXO675_005340	COG3642	lipopolysaccharide core region biosynthetic process
IXO675_005345	COG1234	tRNA 3'-trailer cleavage
IXO675_005350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO675_005360	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO675_005365	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO675_005370	COG0314	molybdopterin synthase activity
IXO675_005400	COG0537	adenosine 5'-monophosphoramidase activity
IXO675_005420	COG0714	Associated with various cellular activities
IXO675_005440	COG0242	peptide deformylase activity
IXO675_005485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO675_005490	COG0726	polysaccharide deacetylase
IXO675_005550	COG1609	Transcriptional regulator
IXO675_005555	COG1028	Short-chain dehydrogenase reductase Sdr
IXO675_005560	COG2851	Citrate transporter
IXO675_005575	COG0642	Histidine kinase
IXO675_005585	COG2197	response regulator
IXO675_005600	COG0583	DNA-binding transcription factor activity
IXO675_005615	COG4191	Histidine kinase
IXO675_005635	COG0280	phosphate acetyltransferase
IXO675_005635	COG0281	malic enzyme
IXO675_005660	COG0352	thiamine-phosphate diphosphorylase activity
IXO675_005665	COG1773	rubredoxin
IXO675_005670	COG2912	Transglutaminase-like superfamily
IXO675_005680	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO675_005690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO675_005715	COG0006	proline dipeptidase activity
IXO675_005750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO675_005765	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO675_005770	COG1561	YicC-like family, N-terminal region
IXO675_005795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO675_005805	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO675_005830	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO675_005885	COG0714	Associated with various cellular activities
IXO675_005905	COG2304	oxidoreductase activity
IXO675_005925	COG1301	dicarboxylic acid transport
IXO675_005930	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO675_005940	COG0739	heme binding
IXO675_005945	COG1376	ErfK ybiS ycfS ynhG family protein
IXO675_005970	COG1022	Amp-dependent synthetase and ligase
IXO675_005995	COG0642	Histidine kinase
IXO675_006015	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO675_006020	COG4149	molybdate abc transporter
IXO675_006025	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO675_006030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO675_006030	COG3453	Protein conserved in bacteria
IXO675_006070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO675_006090	COG2205	protein histidine kinase activity
IXO675_006095	COG0745	RESPONSE REGULATOR receiver
IXO675_006115	COG3039	Transposase
IXO675_006150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO675_006155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO675_006205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO675_006290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO675_006305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO675_006320	COG1842	Phage shock protein A
IXO675_006345	COG0754	glutathionylspermidine amidase activity
IXO675_006400	COG0531	amino acid
IXO675_006405	COG2197	response regulator
IXO675_006420	COG1113	amino acid transport
IXO675_006435	COG1271	oxidase subunit
IXO675_006440	COG1294	oxidase, subunit
IXO675_006450	COG2239	Acts as a magnesium transporter
IXO675_006455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO675_006460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO675_006475	COG1660	Displays ATPase and GTPase activities
IXO675_006480	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO675_006485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO675_006500	COG1137	ATPase activity
IXO675_006505	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO675_006515	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO675_006525	COG0271	Belongs to the BolA IbaG family
IXO675_006530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO675_006550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO675_006565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO675_006575	COG0628	permease
IXO675_006585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO675_006590	COG3178	'Phosphotransferase
IXO675_006605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO675_006610	COG1555	photosystem II stabilization
IXO675_006660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO675_006670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO675_006690	COG0228	four-way junction DNA binding
IXO675_006695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO675_006700	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO675_006715	COG0534	Mate efflux family protein
IXO675_006750	COG0542	response to heat
IXO675_006785	COG4206	TonB-dependent receptor
IXO675_006845	COG0019	diaminopimelate decarboxylase activity
IXO675_006855	COG2814	Major facilitator Superfamily
IXO675_006860	COG4264	IucA IucC family
IXO675_006870	COG4772	TonB-dependent receptor
IXO675_006885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO675_006885	COG4651	solute:proton antiporter activity
IXO675_006920	COG0488	(ABC) transporter
IXO675_006945	COG0657	acetylesterase activity
IXO675_006945	COG2755	lipolytic protein G-D-S-L family
IXO675_006975	COG2207	Transcriptional regulator
IXO675_006980	COG0326	Molecular chaperone. Has ATPase activity
IXO675_007010	COG0174	glutamine synthetase
IXO675_007015	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO675_007025	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO675_007040	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO675_007075	COG2146	nitrite reductase [NAD(P)H] activity
IXO675_007085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO675_007090	COG0719	Fe-S assembly protein
IXO675_007095	COG0396	ATPase activity
IXO675_007100	COG0719	Fe-S assembly protein
IXO675_007105	COG1959	2 iron, 2 sulfur cluster binding
IXO675_007125	COG0693	protein deglycase activity
IXO675_007165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO675_007200	COG0519	Catalyzes the synthesis of GMP from XMP
IXO675_007210	COG1678	Uncharacterized ACR, COG1678
IXO675_007215	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO675_007230	COG1764	response to oxidative stress
IXO675_007240	COG0384	phenazine biosynthesis protein PhzF
IXO675_007250	COG0527	aspartate kinase activity
IXO675_007275	COG0142	geranyltranstransferase activity
IXO675_007280	COG0629	single-stranded DNA binding
IXO675_007285	COG2203	Gaf domain
IXO675_007285	COG3706	GGDEF domain
IXO675_007285	COG4251	negative regulation of phosphorylation
IXO675_007285	COG5001	Diguanylate cyclase
IXO675_007320	COG2879	small protein
IXO675_007325	COG1966	Carbon starvation protein
IXO675_007330	COG1741	Belongs to the pirin family
IXO675_007420	COG1515	deoxyribonuclease V activity
IXO675_007425	COG0588	phosphoglycerate mutase activity
IXO675_007440	COG3590	peptidase
IXO675_007455	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO675_007460	COG2199	diguanylate cyclase activity
IXO675_007460	COG2200	EAL domain
IXO675_007460	COG2202	Pas domain
IXO675_007465	COG0835	chemotaxis
IXO675_007470	COG0840	transmembrane signaling receptor activity
IXO675_007475	COG0643	Histidine kinase
IXO675_007475	COG2198	Histidine kinase
IXO675_007490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO675_007500	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO675_007510	COG2205	protein histidine kinase activity
IXO675_007550	COG3039	Transposase
IXO675_007595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO675_007600	COG0735	belongs to the Fur family
IXO675_007660	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO675_007665	COG0084	hydrolase, TatD family'
IXO675_007680	COG1960	acyl-CoA dehydrogenase activity
IXO675_007695	COG0367	asparagine synthase
IXO675_007705	COG0305	Participates in initiation and elongation during chromosome replication
IXO675_007710	COG0415	Belongs to the DNA photolyase family
IXO675_007725	COG1028	Short-chain dehydrogenase reductase Sdr
IXO675_007825	COG5001	Diguanylate cyclase
IXO675_007825	COG5002	protein histidine kinase activity
IXO675_007830	COG1187	pseudouridine synthase activity
IXO675_007850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO675_007860	COG0475	glutathione-regulated potassium exporter activity
IXO675_007865	COG5002	protein histidine kinase activity
IXO675_007865	COG5000	phosphorelay sensor kinase activity
IXO675_007870	COG0745	RESPONSE REGULATOR receiver
IXO675_007900	COG1132	(ABC) transporter
IXO675_007950	COG3039	Transposase
IXO675_007965	COG3209	COG3209 Rhs family protein
IXO675_007975	COG3039	Transposase
IXO675_008010	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO675_008020	COG4969	Belongs to the N-Me-Phe pilin family
IXO675_008025	COG2194	sulfuric ester hydrolase activity
IXO675_008065	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO675_008070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO675_008085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO675_008085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO675_008090	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO675_008095	COG0564	pseudouridine synthase activity
IXO675_008120	COG3387	PFAM Glycoside hydrolase 15-related
IXO675_008125	COG1877	trehalose-phosphatase activity
IXO675_008165	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO675_008180	COG1595	DNA-templated transcription, initiation
IXO675_008190	COG1946	Acyl-CoA thioesterase
IXO675_008205	COG0824	Thioesterase
IXO675_008210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO675_008220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO675_008225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO675_008230	COG0268	Binds directly to 16S ribosomal RNA
IXO675_008235	COG0728	peptidoglycan biosynthetic process
IXO675_008240	COG0196	riboflavin kinase activity
IXO675_008250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO675_008255	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO675_008270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO675_008275	COG1845	cytochrome c oxidase, subunit III
IXO675_008280	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO675_008420	COG0632	four-way junction helicase activity
IXO675_008430	COG2255	four-way junction helicase activity
IXO675_008435	COG0824	Thioesterase
IXO675_008445	COG0848	biopolymer transport protein
IXO675_008460	COG2885	chlorophyll binding
IXO675_008470	COG0602	queuosine metabolic process
IXO675_008495	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO675_008515	COG0514	ATP-dependent DNA helicase (RecQ)
IXO675_008520	COG0783	Belongs to the Dps family
IXO675_008525	COG1643	Atp-dependent helicase
IXO675_008550	COG0535	radical SAM domain protein
IXO675_008555	COG0535	radical SAM domain protein
IXO675_008560	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IXO675_008575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO675_008585	COG1215	transferase activity, transferring glycosyl groups
IXO675_008590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO675_008600	COG1199	ATP-dependent helicase activity
IXO675_008610	COG1397	ADP-ribosylglycohydrolase
IXO675_008620	COG0189	ligase activity
IXO675_008635	COG0835	chemotaxis
IXO675_008640	COG0840	transmembrane signaling receptor activity
IXO675_008645	COG0643	Histidine kinase
IXO675_008645	COG0784	Response regulator, receiver
IXO675_008645	COG2198	Histidine kinase
IXO675_008685	COG1446	asparaginase
IXO675_008730	COG3537	Alpha-1,2-mannosidase
IXO675_008745	COG3039	Transposase
IXO675_008775	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO675_008785	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO675_008795	COG1388	LysM domain
IXO675_008795	COG3858	chitin binding
IXO675_008810	COG0837	glucose binding
IXO675_008815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO675_008825	COG0494	nUDIX hydrolase
IXO675_008835	COG3956	TIGRFAM MazG family protein
IXO675_008840	COG1742	UPF0060 membrane protein
IXO675_008850	COG0330	HflC and HflK could
IXO675_008865	COG0509	glycine decarboxylation via glycine cleavage system
IXO675_008895	COG1960	acyl-CoA dehydrogenase activity
IXO675_008905	COG1309	transcriptional regulator
IXO675_008910	COG4771	TonB-dependent receptor
IXO675_008920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO675_008930	COG0463	Glycosyl transferase, family 2
IXO675_008950	COG1272	protein, Hemolysin III
IXO675_008955	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IXO675_008960	COG0739	heme binding
IXO675_008965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO675_008970	COG0626	cystathionine gamma-synthase activity
IXO675_008980	COG1760	l-serine dehydratase
IXO675_008995	COG2353	YceI-like domain
IXO675_009005	COG2353	YceI-like domain
IXO675_009080	COG1960	acyl-CoA dehydrogenase activity
IXO675_009085	COG1024	Enoyl-CoA hydratase
IXO675_009105	COG1024	Enoyl-CoA hydratase
IXO675_009105	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO675_009120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO675_009150	COG1381	Involved in DNA repair and RecF pathway recombination
IXO675_009165	COG2954	triphosphatase activity
IXO675_009190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO675_009195	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IXO675_009200	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO675_009210	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO675_009215	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO675_009220	COG1278	Cold shock
IXO675_009240	COG1201	RNA secondary structure unwinding
IXO675_009245	COG1793	dna ligase
IXO675_009255	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO675_009255	COG1793	dna ligase
IXO675_009285	COG0183	Belongs to the thiolase family
IXO675_009305	COG1451	nucleotide metabolic process
IXO675_009320	COG3039	Transposase
IXO675_009325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO675_009330	COG3039	Transposase
IXO675_009375	COG1047	Peptidyl-prolyl cis-trans
IXO675_009390	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO675_009400	COG1902	pentaerythritol trinitrate reductase activity
IXO675_009405	COG2814	Major facilitator Superfamily
IXO675_009440	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO675_009440	COG0392	lysyltransferase activity
IXO675_009450	COG0251	oxidation-reduction process
IXO675_009455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO675_009470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO675_009495	COG1595	DNA-templated transcription, initiation
IXO675_009510	COG2878	Part of a membrane complex involved in electron transport
IXO675_009520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO675_009520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO675_009540	COG0833	amino acid
IXO675_009545	COG2040	homocysteine
IXO675_009565	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO675_009600	COG2895	sulfate adenylyltransferase (ATP) activity
IXO675_009600	COG0529	Catalyzes the synthesis of activated sulfate
IXO675_009645	COG1981	membrane
IXO675_009675	COG4771	TonB-dependent receptor
IXO675_009685	COG0825	malonyl-CoA metabolic process
IXO675_009705	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO675_009710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO675_009730	COG0750	zinc metalloprotease
IXO675_009740	COG0575	Belongs to the CDS family
IXO675_009750	COG0233	cytoplasmic translational termination
IXO675_009765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO675_009825	COG1393	Belongs to the ArsC family
IXO675_009835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO675_009840	COG0367	asparagine synthase
IXO675_009850	COG4774	siderophore transport
IXO675_009875	COG2207	Transcriptional regulator
IXO675_009890	COG1566	PFAM secretion protein HlyD family protein
IXO675_009895	COG2814	Major facilitator Superfamily
IXO675_009940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO675_009955	COG1960	acyl-CoA dehydrogenase activity
IXO675_009970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO675_009980	COG2914	Belongs to the UPF0125 (RnfH) family
IXO675_009985	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO675_009995	COG0497	DNA recombination
IXO675_010005	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO675_010015	COG0484	heat shock protein binding
IXO675_010020	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO675_010025	COG0287	Prephenate dehydrogenase
IXO675_010025	COG1605	Chorismate mutase
IXO675_010040	COG0583	DNA-binding transcription factor activity
IXO675_010055	COG1132	(ABC) transporter
IXO675_010090	COG2850	peptidyl-arginine hydroxylation
IXO675_010165	COG1131	(ABC) transporter
IXO675_010170	COG1725	Transcriptional regulator
IXO675_010180	COG0386	Belongs to the glutathione peroxidase family
IXO675_010195	COG2900	Belongs to the SlyX family
IXO675_010210	COG1609	Transcriptional regulator
IXO675_010220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO675_010230	COG1410	methionine synthase
IXO675_010230	COG0646	methionine synthase
IXO675_010235	COG0646	methionine synthase
IXO675_010235	COG1410	methionine synthase
IXO675_010240	COG2226	methyltransferase
IXO675_010245	COG1960	acyl-CoA dehydrogenase activity
IXO675_010280	COG0557	exoribonuclease II activity
IXO675_010295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO675_010305	COG3039	Transposase
IXO675_010325	COG1278	Cold shock
IXO675_010410	COG3039	Transposase
IXO675_010420	COG0583	DNA-binding transcription factor activity
IXO675_010485	COG0742	ribosomal rna small subunit methyltransferase
IXO675_010490	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO675_010500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO675_010505	COG0405	Gamma-glutamyltransferase
IXO675_010625	COG3039	Transposase
IXO675_010665	COG0343	queuine tRNA-ribosyltransferase activity
IXO675_010670	COG1862	Preprotein translocase
IXO675_010675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO675_010680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO675_010710	COG3328	transposase activity
IXO675_010725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO675_010735	COG0704	Plays a role in the regulation of phosphate uptake
IXO675_010750	COG0573	inorganic phosphate transmembrane transporter activity
IXO675_010755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO675_010790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO675_010800	COG1024	Enoyl-CoA hydratase
IXO675_010815	COG0494	nUDIX hydrolase
IXO675_010860	COG0116	Belongs to the methyltransferase superfamily
IXO675_010860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO675_010885	COG0667	Aldo Keto reductase
IXO675_010895	COG2925	Exonuclease
IXO675_010930	COG0288	reversible hydration of carbon dioxide
IXO675_010960	COG0316	Belongs to the HesB IscA family
IXO675_010965	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO675_010975	COG0359	binds to the 23S rRNA
IXO675_010985	COG3115	cell septum assembly
IXO675_011005	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO675_011020	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO675_011045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO675_011055	COG2986	histidine ammonia-lyase
IXO675_011060	COG1228	amidohydrolase
IXO675_011100	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO675_011105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IXO675_011110	COG0077	Prephenate dehydratase
IXO675_011110	COG1605	Chorismate mutase
IXO675_011115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO675_011145	COG4566	intracellular signal transduction
IXO675_011190	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO675_011195	COG1469	GTP cyclohydrolase I activity
IXO675_011205	COG0617	tRNA 3'-terminal CCA addition
IXO675_011215	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO675_011220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO675_011250	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO675_011265	COG2203	Gaf domain
IXO675_011265	COG3706	GGDEF domain
IXO675_011265	COG4251	negative regulation of phosphorylation
IXO675_011265	COG5001	Diguanylate cyclase
IXO675_011350	COG0386	Belongs to the glutathione peroxidase family
IXO675_011435	COG1247	-acetyltransferase
IXO675_011455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IXO675_011480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO675_011495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO675_011500	COG1393	Belongs to the ArsC family
IXO675_011505	COG0431	NADPH-dependent FMN reductase
IXO675_011510	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IXO675_011515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO675_011535	COG0784	Response regulator, receiver
IXO675_011535	COG2205	protein histidine kinase activity
IXO675_011535	COG5002	protein histidine kinase activity
IXO675_011565	COG0800	Aldolase
IXO675_011570	COG0129	dihydroxy-acid dehydratase activity
IXO675_011575	COG0363	glucosamine-6-phosphate deaminase activity
IXO675_011585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO675_011600	COG0354	folic acid binding
IXO675_011615	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO675_011630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO675_011645	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO675_011670	COG0811	peptide transport
IXO675_011685	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO675_011695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO675_011705	COG0322	excinuclease ABC activity
IXO675_011755	COG2801	Transposase and inactivated derivatives
IXO675_011765	COG2201	protein-glutamate methylesterase activity
IXO675_011815	COG0653	protein targeting
IXO675_011990	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO675_011990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO675_012000	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO675_012010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO675_012010	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO675_012025	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO675_012045	COG0124	histidyl-tRNA synthetase
IXO675_012060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO675_012095	COG1012	belongs to the aldehyde dehydrogenase family
IXO675_012120	COG0697	spore germination
IXO675_012125	COG1794	racemase activity, acting on amino acids and derivatives
IXO675_012145	COG0671	phosphoesterase, PA-phosphatase related
IXO675_012160	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO675_012175	COG2183	response to ionizing radiation
IXO675_012185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO675_012185	COG0723	plastoquinol--plastocyanin reductase activity
IXO675_012200	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO675_012210	COG1183	phosphatidylcholine synthase activity
IXO675_012215	COG1028	Short-chain dehydrogenase reductase Sdr
IXO675_012240	COG0668	transmembrane transport
IXO675_012260	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO675_012305	COG0583	DNA-binding transcription factor activity
IXO675_012310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO675_012330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO675_012350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO675_012360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO675_012365	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO675_012375	COG0776	regulation of translation
IXO675_012380	COG0539	negative regulation of cytoplasmic translation
IXO675_012385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO675_012400	COG2957	Belongs to the agmatine deiminase family
IXO675_012410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO675_012435	COG0395	ABC-type sugar transport system, permease component
IXO675_012440	COG1175	transmembrane transport
IXO675_012470	COG2350	Protein conserved in bacteria
IXO675_012475	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO675_012480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO675_012485	COG1187	pseudouridine synthase activity
IXO675_012510	COG0436	Aminotransferase
IXO675_012575	COG0277	FAD linked oxidase domain protein
IXO675_012580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO675_012590	COG0531	amino acid
IXO675_012595	COG0531	amino acid
IXO675_012605	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO675_012610	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IXO675_012645	COG3039	Transposase
IXO675_012655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO675_012660	COG3039	Transposase
IXO675_012735	COG0303	'Molybdopterin
IXO675_012745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO675_012755	COG1426	Protein conserved in bacteria
IXO675_012765	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO675_012780	COG1024	Enoyl-CoA hydratase
IXO675_012780	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO675_012785	COG0183	Belongs to the thiolase family
IXO675_012795	COG0038	chloride channel
IXO675_012815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO675_012835	COG1674	ftsk spoiiie
IXO675_012840	COG0492	ferredoxin-NADP+ reductase activity
IXO675_012865	COG0542	response to heat
IXO675_012880	COG0482	sulfurtransferase activity
IXO675_012905	COG5001	Diguanylate cyclase
IXO675_012910	COG4585	Histidine kinase
IXO675_012920	COG5002	protein histidine kinase activity
IXO675_012940	COG0784	Response regulator, receiver
IXO675_012940	COG0835	chemotaxis
IXO675_012950	COG1558	bacterial-type flagellum-dependent cell motility
IXO675_012955	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO675_012965	COG4787	bacterial-type flagellum-dependent cell motility
IXO675_013000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO675_013005	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO675_013035	COG2201	protein-glutamate methylesterase activity
IXO675_013055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO675_013065	COG1028	Short-chain dehydrogenase reductase Sdr
IXO675_013095	COG1677	Flagellar hook-basal body complex protein FliE
IXO675_013145	COG3190	flagellar
IXO675_013160	COG1684	flagellar biosynthetic protein fliR
IXO675_013215	COG0784	Response regulator, receiver
IXO675_013215	COG0643	Histidine kinase
IXO675_013215	COG2198	Histidine kinase
IXO675_013240	COG3209	COG3209 Rhs family protein
IXO675_013340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO675_013345	COG4988	ABC transporter
IXO675_013365	COG1271	oxidase subunit
IXO675_013395	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO675_013415	COG0165	Argininosuccinate lyase
IXO675_013430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO675_013435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO675_013445	COG0137	argininosuccinate synthase activity
IXO675_013450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO675_013465	COG2166	iron-sulfur cluster assembly
IXO675_013490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO675_013520	COG3039	Transposase
IXO675_013540	COG4677	pectinesterase activity
IXO675_013555	COG3039	Transposase
IXO675_013570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO675_013575	COG0402	S-adenosylhomocysteine deaminase activity
IXO675_013590	COG1509	lysine 2,3-aminomutase activity
IXO675_013595	COG5001	Diguanylate cyclase
IXO675_013595	COG3300	MHYT domain
IXO675_013610	COG0483	inositol monophosphate 1-phosphatase activity
IXO675_013615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO675_013635	COG0488	(ABC) transporter
IXO675_013640	COG0513	Belongs to the DEAD box helicase family
IXO675_013660	COG0625	glutathione transferase activity
IXO675_013670	COG1671	Belongs to the UPF0178 family
IXO675_013675	COG4681	YaeQ
IXO675_013680	COG2081	HI0933 family
IXO675_013690	COG0501	Belongs to the peptidase M48B family
IXO675_013700	COG1028	Short-chain dehydrogenase reductase Sdr
IXO675_013720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO675_013725	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO675_013730	COG0802	atpase or kinase
IXO675_013735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO675_013735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO675_013740	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO675_013745	COG1570	exodeoxyribonuclease VII activity
IXO675_013760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO675_013835	COG3328	transposase activity
IXO675_013870	COG2969	positive regulation of protein catabolic process
IXO675_013875	COG0625	glutathione transferase activity
IXO675_013880	COG2857	Cytochrome c1
IXO675_013885	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO675_013890	COG0723	plastoquinol--plastocyanin reductase activity
IXO675_013895	COG0741	lytic transglycosylase activity
IXO675_013915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IXO675_013920	COG1702	phosphate starvation-inducible protein PhoH
IXO675_013940	COG4535	Mg2 and Co2 transporter CorC
IXO675_013955	COG1012	belongs to the aldehyde dehydrogenase family
IXO675_013965	COG1177	transmembrane transport
IXO675_013975	COG3842	ATPase activity
IXO675_014010	COG0174	glutamine synthetase
IXO675_014015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO675_014025	COG0477	Major facilitator Superfamily
IXO675_014035	COG0243	molybdopterin cofactor binding
IXO675_014045	COG2223	nitrite transmembrane transporter activity
IXO675_014050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO675_014055	COG1121	(ABC) transporter
IXO675_014065	COG2733	membrane
IXO675_014070	COG5002	protein histidine kinase activity
IXO675_014070	COG2205	protein histidine kinase activity
IXO675_014070	COG0784	Response regulator, receiver
IXO675_014080	COG3039	Transposase
IXO675_014085	COG2902	Dehydrogenase
IXO675_014095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO675_014100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO675_014120	COG1609	Transcriptional regulator
IXO675_014125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO675_014125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO675_014130	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO675_014135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO675_014135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO675_014145	COG3039	Transposase
IXO675_014255	COG3039	Transposase
IXO675_014290	COG3039	Transposase
IXO675_014320	COG4771	TonB-dependent receptor
IXO675_014330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO675_014350	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO675_014355	COG1360	Flagellar Motor Protein
IXO675_014365	COG0835	chemotaxis
IXO675_014375	COG0745	RESPONSE REGULATOR receiver
IXO675_014395	COG0840	transmembrane signaling receptor activity
IXO675_014405	COG0840	transmembrane signaling receptor activity
IXO675_014410	COG3039	Transposase
IXO675_014425	COG0840	transmembrane signaling receptor activity
IXO675_014435	COG0840	transmembrane signaling receptor activity
IXO675_014440	COG0840	transmembrane signaling receptor activity
IXO675_014445	COG0840	transmembrane signaling receptor activity
IXO675_014450	COG0840	transmembrane signaling receptor activity
IXO675_014465	COG0835	chemotaxis
IXO675_014480	COG3039	Transposase
IXO675_014530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO675_014560	COG0318	PFAM AMP-dependent synthetase and ligase
IXO675_014565	COG1024	Enoyl-CoA hydratase
IXO675_014570	COG2198	Histidine kinase
IXO675_014570	COG2205	protein histidine kinase activity
IXO675_014570	COG0784	Response regulator, receiver
IXO675_014635	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO675_014645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO675_014650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO675_014660	COG0505	Belongs to the CarA family
IXO675_014665	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO675_014675	COG2258	MOSC domain
IXO675_014680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO675_014730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO675_014750	COG0477	Major facilitator Superfamily
IXO675_014760	COG1070	Carbohydrate kinase
IXO675_014770	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO675_014785	COG0800	Aldolase
IXO675_014790	COG4948	Mandelate Racemase Muconate Lactonizing
IXO675_014800	COG3734	2-keto-3-deoxy-galactonokinase
IXO675_014805	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO675_014815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO675_014830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO675_014835	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO675_014845	COG0351	phosphomethylpyrimidine kinase
IXO675_014875	COG0583	DNA-binding transcription factor activity
IXO675_014880	COG1741	Belongs to the pirin family
IXO675_014905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO675_014910	COG0305	Participates in initiation and elongation during chromosome replication
IXO675_014930	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO675_014935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO675_014940	COG2137	regulation of response to DNA damage stimulus
IXO675_014945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO675_014960	COG1546	Belongs to the CinA family
IXO675_014965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO675_014975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO675_014980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO675_014990	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO675_014995	COG1534	Rna-binding protein
IXO675_015010	COG1238	metal cluster binding
IXO675_015015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO675_015020	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO675_015025	COG2840	Smr protein MutS2
IXO675_015035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO675_015045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO675_015050	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO675_015055	COG0148	phosphopyruvate hydratase activity
IXO675_015065	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO675_015070	COG0504	CTP synthase activity
IXO675_015100	COG0306	phosphate transporter
IXO675_015110	COG1253	flavin adenine dinucleotide binding
IXO675_015125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO675_015135	COG0477	Major facilitator Superfamily
IXO675_015145	COG1132	(ABC) transporter
IXO675_015150	COG1136	(ABC) transporter
IXO675_015165	COG0438	transferase activity, transferring glycosyl groups
IXO675_015175	COG2264	protein methyltransferase activity
IXO675_015205	COG2244	polysaccharide biosynthetic process
IXO675_015255	COG1595	DNA-templated transcription, initiation
IXO675_015270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO675_015290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO675_015335	COG2201	protein-glutamate methylesterase activity
IXO675_015355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO675_015360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO675_015415	COG1858	cytochrome C peroxidase
IXO675_015445	COG0515	serine threonine protein kinase
IXO675_015450	COG0631	protein serine/threonine phosphatase activity
IXO675_015560	COG3039	Transposase
IXO675_015590	COG0316	Belongs to the HesB IscA family
IXO675_015590	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IXO675_015595	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO675_015605	COG0428	transporter
IXO675_015610	COG0428	transporter
IXO675_015615	COG3064	Membrane
IXO675_015625	COG1530	ribonuclease E activity
IXO675_015640	COG1054	Belongs to the UPF0176 family
IXO675_015660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO675_015695	COG3039	Transposase
IXO675_015700	COG3039	Transposase
IXO675_015740	COG1648	precorrin-2 dehydrogenase activity
IXO675_015740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO675_015765	COG0746	molybdenum cofactor guanylyltransferase activity
IXO675_015845	COG4206	TonB-dependent receptor
IXO675_015895	COG0531	amino acid
IXO675_015910	COG0006	proline dipeptidase activity
IXO675_015920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO675_015935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO675_015940	COG3938	Belongs to the proline racemase family
IXO675_015950	COG0552	protein localization to endoplasmic reticulum
IXO675_015970	COG0784	Response regulator, receiver
IXO675_015970	COG4191	Histidine kinase
IXO675_016055	COG3040	lipid binding
IXO675_016095	COG0438	transferase activity, transferring glycosyl groups
IXO675_016105	COG0438	transferase activity, transferring glycosyl groups
IXO675_016110	COG0438	transferase activity, transferring glycosyl groups
IXO675_016165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO675_016170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IXO675_016180	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO675_016220	COG0556	nucleotide-excision repair
IXO675_016225	COG4969	Belongs to the N-Me-Phe pilin family
IXO675_016265	COG1611	Belongs to the LOG family
IXO675_016280	COG2095	MarC family integral membrane protein
IXO675_016290	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO675_016325	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO675_016330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO675_016350	COG0195	Participates in both transcription termination and antitermination
IXO675_016355	COG0779	Required for maturation of 30S ribosomal subunits
IXO675_016365	COG1007	ATP synthesis coupled electron transport
IXO675_016395	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO675_016400	COG1034	ATP synthesis coupled electron transport
IXO675_016405	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO675_016410	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO675_016415	COG0649	NAD binding
IXO675_016420	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO675_016430	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO675_016445	COG0149	triose-phosphate isomerase activity
IXO675_016500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO675_016505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO675_016510	COG0159	tryptophan synthase activity
IXO675_016520	COG0133	tryptophan synthase activity
IXO675_016530	COG0135	phosphoribosylanthranilate isomerase activity
IXO675_016535	COG0101	tRNA pseudouridine synthase activity
IXO675_016555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO675_016560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO675_016565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO675_016570	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO675_016615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO675_016625	COG0412	Dienelactone hydrolase
IXO675_016645	COG0717	Belongs to the dCTP deaminase family
IXO675_016650	COG0489	protein tyrosine kinase activity
IXO675_016690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO675_016695	COG2311	Membrane
IXO675_016700	COG1047	Peptidyl-prolyl cis-trans
IXO675_016705	COG0791	NLP P60 protein
IXO675_016710	COG0791	NLP P60 protein
IXO675_016725	COG1301	dicarboxylic acid transport
IXO675_016730	COG1785	Belongs to the alkaline phosphatase family
IXO675_016735	COG0037	tRNA processing
IXO675_016740	COG1722	exodeoxyribonuclease VII activity
IXO675_016745	COG0142	geranyltranstransferase activity
IXO675_016770	COG0312	modulator of DNA gyrase
IXO675_016780	COG0312	modulator of DNA gyrase
IXO675_016790	COG3164	Protein of unknown function
IXO675_016805	COG2968	Membrane
IXO675_016810	COG3039	Transposase
IXO675_016840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO675_016865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO675_016890	COG3118	belongs to the thioredoxin family
IXO675_016935	COG3039	Transposase
IXO675_017055	COG2022	thiamine diphosphate biosynthetic process
IXO675_017065	COG0471	metal ion transport
IXO675_017065	COG3273	potassium ion transport
IXO675_017095	COG1970	mechanosensitive ion channel activity
IXO675_017130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO675_017155	COG0308	aminopeptidase N
IXO675_017160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO675_017170	COG0529	Catalyzes the synthesis of activated sulfate
IXO675_017170	COG2895	sulfate adenylyltransferase (ATP) activity
IXO675_017175	COG0175	sulfate reduction
IXO675_017180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO675_017185	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO675_017190	COG0175	sulfate reduction
IXO675_017210	COG0784	Response regulator, receiver
IXO675_017210	COG2198	Histidine kinase
IXO675_017210	COG2205	protein histidine kinase activity
IXO675_017255	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO675_017260	COG3588	fructose-bisphosphate aldolase
IXO675_017265	COG0469	pyruvate kinase activity
IXO675_017295	COG3039	Transposase
IXO675_017310	COG0753	catalase activity
IXO675_017335	COG1917	Cupin 2, conserved barrel domain protein
IXO675_017335	COG2207	Transcriptional regulator
IXO675_017355	COG0823	Involved in the tonB-independent uptake of proteins
IXO675_017355	COG1506	peptidase
IXO675_017375	COG1297	OPT oligopeptide transporter protein
IXO675_017390	COG0587	DNA-directed DNA polymerase activity
IXO675_017460	COG0732	type I restriction modification DNA specificity domain
IXO675_017495	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO675_017820	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO675_017835	COG2197	response regulator
IXO675_017840	COG4585	Histidine kinase
IXO675_017860	COG2894	cell division
IXO675_017865	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO675_017875	COG0642	Histidine kinase
IXO675_017880	COG0745	RESPONSE REGULATOR receiver
IXO675_017885	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO675_017895	COG2194	sulfuric ester hydrolase activity
IXO675_017925	COG3551	Protein conserved in bacteria
IXO675_017975	COG0203	ribosomal protein L17
IXO675_017985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO675_017990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO675_018000	COG0201	protein transport
IXO675_018010	COG1841	ribosomal large subunit assembly
IXO675_018040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO675_018050	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO675_018055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO675_018060	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO675_018065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO675_018075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO675_018090	COG0089	rRNA binding
IXO675_018095	COG0088	Forms part of the polypeptide exit tunnel
IXO675_018100	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO675_018105	COG0051	transcription antitermination factor activity, RNA binding
IXO675_018125	COG0049	tRNA binding
IXO675_018130	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO675_018135	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO675_018140	COG0085	RNA polymerase activity
IXO675_018145	COG0222	ribosome binding
IXO675_018150	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO675_018160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO675_018165	COG0250	Participates in transcription elongation, termination and antitermination
IXO675_018170	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO675_018200	COG0012	GTP binding
IXO675_018205	COG0193	aminoacyl-tRNA hydrolase activity
IXO675_018215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO675_018230	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO675_018240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO675_018245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO675_018255	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO675_018275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO675_018280	COG1295	ribonuclease BN
IXO675_018310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO675_018315	COG1404	Belongs to the peptidase S8 family
IXO675_018320	COG1404	Belongs to the peptidase S8 family
IXO675_018330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO675_018355	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO675_018380	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO675_018395	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO675_018395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO675_018435	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO675_018445	COG3634	alkyl hydroperoxide reductase activity
IXO675_018450	COG0583	DNA-binding transcription factor activity
IXO675_018455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO675_018460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO675_018505	COG2197	response regulator
IXO675_018630	COG3386	PFAM SMP-30 Gluconolaconase
IXO675_018650	COG1024	Enoyl-CoA hydratase
IXO675_018660	COG0318	PFAM AMP-dependent synthetase and ligase
IXO675_018665	COG0583	DNA-binding transcription factor activity
IXO675_018705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO675_018710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO675_018720	COG2096	Adenosyltransferase
IXO675_018725	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO675_018740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO675_018750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO675_018755	COG2967	ApaG domain
IXO675_018760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IXO675_018780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO675_018800	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO675_018825	COG0642	Histidine kinase
IXO675_018840	COG4181	ATPase activity
IXO675_018850	COG2175	clavaminate synthase activity
IXO675_018905	COG0667	Aldo Keto reductase
IXO675_018915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO675_018920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO675_018930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO675_018945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO675_018985	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO675_018990	COG3039	Transposase
IXO675_018995	COG2226	methyltransferase
IXO675_019040	COG0604	alcohol dehydrogenase
IXO675_019040	COG1028	Short-chain dehydrogenase reductase Sdr
IXO675_019040	COG3321	synthase
IXO675_019050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO675_019070	COG0494	nUDIX hydrolase
IXO675_019080	COG0653	protein targeting
IXO675_019085	COG4942	peptidase
IXO675_019085	COG1388	LysM domain
IXO675_019095	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO675_019110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO675_019115	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO675_019120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO675_019135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO675_019140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO675_019155	COG3116	cell division
IXO675_019160	COG0275	rRNA processing
IXO675_019195	COG0792	nuclease activity
IXO675_019200	COG1988	membrane-bound metal-dependent
IXO675_019205	COG0277	FAD linked oxidase domain protein
IXO675_019210	COG0745	RESPONSE REGULATOR receiver
IXO675_019215	COG2205	protein histidine kinase activity
IXO675_019225	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO675_019230	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO675_019250	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO675_019255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO675_019260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO675_019280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO675_019280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO675_019300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO675_019320	COG0488	(ABC) transporter
IXO675_019370	COG2205	protein histidine kinase activity
IXO675_019405	COG2205	protein histidine kinase activity
IXO675_019420	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO675_019450	COG3039	Transposase
IXO675_019460	COG3039	Transposase
IXO675_019465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO675_019560	COG3039	Transposase
IXO675_019570	COG3039	Transposase
IXO675_019605	COG0726	polysaccharide deacetylase
IXO675_019605	COG1649	PFAM Uncharacterised BCR, COG1649
IXO675_019610	COG1215	transferase activity, transferring glycosyl groups
IXO675_019620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO675_019625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO675_019630	COG1609	Transcriptional regulator
IXO675_019640	COG2188	Transcriptional regulator
IXO675_019655	COG3250	beta-galactosidase activity
IXO675_019705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO675_019710	COG4191	Histidine kinase
IXO675_019715	COG0784	Response regulator, receiver
IXO675_019720	COG4251	negative regulation of phosphorylation
IXO675_019725	COG2823	Periplasmic or secreted lipoprotein
IXO675_019730	COG0673	inositol 2-dehydrogenase activity
IXO675_019735	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO675_019770	COG1051	belongs to the nudix hydrolase family
IXO675_019770	COG1056	cytidyltransferase-related domain
IXO675_019795	COG2921	Belongs to the UPF0250 family
IXO675_019810	COG1686	Belongs to the peptidase S11 family
IXO675_019815	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO675_019820	COG2951	lytic endotransglycosylase activity
IXO675_019840	COG1388	LysM domain
IXO675_019840	COG3409	Peptidoglycan-binding domain 1 protein
IXO675_019840	COG5632	N-Acetylmuramoyl-L-alanine amidase
IXO675_019900	COG0772	Belongs to the SEDS family
IXO675_019915	COG1792	Involved in formation and maintenance of cell shape
IXO675_019920	COG1077	Cell shape determining protein MreB Mrl
IXO675_019925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO675_019930	COG3039	Transposase
IXO675_019980	COG2199	diguanylate cyclase activity
IXO675_019985	COG0308	aminopeptidase N
IXO675_020015	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO675_020045	COG0436	Aminotransferase
IXO675_020060	COG1505	serine-type exopeptidase activity
IXO675_020085	COG0181	hydroxymethylbilane synthase activity
IXO675_020095	COG3275	phosphorelay sensor kinase activity
IXO675_020140	COG0659	secondary active sulfate transmembrane transporter activity
IXO675_020145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO675_020145	COG5297	Belongs to the glycosyl hydrolase family 6
IXO675_020205	COG3039	Transposase
IXO675_020225	COG0598	Magnesium transport protein CorA
IXO675_020235	COG1113	amino acid transport
IXO675_020245	COG5297	Belongs to the glycosyl hydrolase family 6
IXO675_020250	COG4305	rare lipoprotein A
IXO675_020255	COG0697	spore germination
IXO675_020315	COG4221	oxidoreductase activity
IXO675_020345	COG0456	acetyltransferase
IXO675_020355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO675_020400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO675_020400	COG2111	Na H antiporter
IXO675_020405	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO675_020410	COG0651	ATP synthesis coupled electron transport
IXO675_020420	COG2212	antiporter activity
IXO675_020425	COG1320	monovalent cation:proton antiporter activity
IXO675_020435	COG3039	Transposase
IXO675_020440	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO675_020460	COG3104	oligopeptide transport
IXO675_020465	COG3483	tryptophan 2,3-dioxygenase activity
IXO675_020475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IXO675_020510	COG0183	Belongs to the thiolase family
IXO675_020555	COG3039	Transposase
IXO675_020590	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO675_020595	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO675_020610	COG4948	Mandelate Racemase Muconate Lactonizing
IXO675_020635	COG0531	amino acid
IXO675_020660	COG4682	membrane
IXO675_020670	COG2133	pyrroloquinoline quinone binding
IXO675_020715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO675_020720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO675_020730	COG1610	YqeY-like protein
IXO675_020745	COG1295	ribonuclease BN
IXO675_020750	COG0358	DNA primase activity
IXO675_020890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO675_020900	COG1560	Kdo2-lipid A biosynthetic process
IXO675_020950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO675_020950	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO675_020955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO675_020960	COG0242	peptide deformylase activity
IXO675_020965	COG1652	LysM domain
IXO675_020970	COG0758	DNA mediated transformation
IXO675_020975	COG2922	Belongs to the Smg family
IXO675_020990	COG1754	DNA topoisomerase type I activity
IXO675_020990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO675_020995	COG0009	L-threonylcarbamoyladenylate synthase
IXO675_021010	COG1028	Short-chain dehydrogenase reductase Sdr
IXO675_021020	COG0616	signal peptide processing
IXO675_021025	COG0534	Mate efflux family protein
IXO675_021045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO675_021080	COG1324	tolerance protein
IXO675_021090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO675_021095	COG0511	ligase activity, forming carbon-carbon bonds
IXO675_021105	COG0439	Biotin carboxylase
IXO675_021150	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO675_021185	COG2831	hemolysin activation secretion protein
IXO675_021220	COG2267	carboxylic ester hydrolase activity
IXO675_021225	COG2267	carboxylic ester hydrolase activity
IXO675_021240	COG0419	ATPase involved in DNA repair
IXO675_021250	COG0151	Belongs to the GarS family
IXO675_021255	COG0577	efflux transmembrane transporter activity
IXO675_021255	COG1136	(ABC) transporter
IXO675_021265	COG1289	transmembrane transporter activity
IXO675_021280	COG2814	Major facilitator Superfamily
IXO675_021295	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO675_021330	COG0745	RESPONSE REGULATOR receiver
IXO675_021375	COG0739	heme binding
IXO675_021390	COG2211	Major facilitator Superfamily
IXO675_021395	COG0708	Exodeoxyribonuclease III
IXO675_021410	COG1192	Involved in chromosome partitioning
IXO675_021415	COG1475	DNA binding
IXO675_021430	COG0463	Glycosyl transferase, family 2
IXO675_021455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO675_021480	COG4221	oxidoreductase activity
IXO675_021505	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO675_021510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO675_021525	COG3485	protocatechuate 3,4-dioxygenase
IXO675_021530	COG3485	protocatechuate 3,4-dioxygenase
IXO675_021570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO675_021575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO675_021585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO675_021585	COG1042	CoA-binding domain protein
IXO675_021585	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO675_021595	COG2239	Acts as a magnesium transporter
IXO675_021610	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO675_021615	COG3387	PFAM Glycoside hydrolase 15-related
IXO675_021630	COG3100	YcgL domain-containing protein
IXO675_021635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO675_021645	COG0463	Glycosyl transferase, family 2
IXO675_021660	COG1028	Short-chain dehydrogenase reductase Sdr
IXO675_021670	COG0156	8-amino-7-oxononanoate synthase activity
IXO675_021675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO675_021680	COG1040	competence protein
IXO675_021685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO675_021695	COG0628	permease
IXO675_021705	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO675_021715	COG1595	DNA-templated transcription, initiation
IXO675_021720	COG0753	catalase activity
IXO675_021770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO675_021775	COG0180	Tryptophanyl-tRNA synthetase
IXO675_021780	COG3237	CsbD-like
IXO675_021815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO675_021830	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO675_021835	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO675_021835	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO675_021875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO675_021895	COG1566	PFAM secretion protein HlyD family protein
IXO675_021910	COG1199	ATP-dependent helicase activity
IXO675_021950	COG0583	DNA-binding transcription factor activity
IXO675_021995	COG0625	glutathione transferase activity
IXO675_022030	COG4555	ABC transporter
IXO675_022040	COG1476	TRANSCRIPTIONal
IXO675_022060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO675_022065	COG1131	(ABC) transporter
IXO675_022070	COG0842	Transport permease protein
IXO675_022080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO675_022145	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO675_022155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO675_022165	COG0564	pseudouridine synthase activity
IXO675_022195	COG0339	signal peptide processing
IXO675_022230	COG3254	rhamnose metabolic process
IXO675_022235	COG0738	Major facilitator superfamily
IXO675_022240	COG1414	Transcriptional regulator
IXO675_022255	COG2205	protein histidine kinase activity
IXO675_022265	COG3459	Glycosyltransferase 36 associated
IXO675_022270	COG2211	Major facilitator Superfamily
IXO675_022275	COG3265	gluconokinase activity
IXO675_022280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO675_022320	COG3039	Transposase
IXO675_022380	COG1127	ABC transporter
IXO675_022385	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO675_022390	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO675_022405	COG2853	Lipoprotein
IXO675_022425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO675_022490	COG0676	glucose-6-phosphate 1-epimerase activity
IXO675_022510	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO675_022520	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO675_022530	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO675_022535	COG1064	alcohol dehydrogenase
IXO675_022585	COG1522	sequence-specific DNA binding
IXO675_022590	COG3186	Phenylalanine-4-hydroxylase
IXO675_022630	COG0656	L-ascorbic acid biosynthetic process
IXO675_022640	COG2130	NADP-dependent
IXO675_022645	COG0667	Aldo Keto reductase
IXO675_022655	COG1187	pseudouridine synthase activity
IXO675_022665	COG1643	Atp-dependent helicase
IXO675_022670	COG4807	Protein conserved in bacteria
IXO675_022675	COG4948	Mandelate Racemase Muconate Lactonizing
IXO675_022685	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO675_022690	COG1028	Short-chain dehydrogenase reductase Sdr
IXO675_022710	COG3507	Belongs to the glycosyl hydrolase 43 family
IXO675_022750	COG3162	membrane
IXO675_022755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO675_022770	COG0708	Exodeoxyribonuclease III
IXO675_022785	COG2091	lysine biosynthetic process via aminoadipic acid
IXO675_022795	COG3540	Alkaline phosphatase
IXO675_022800	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO675_022830	COG2159	amidohydrolase
IXO675_022840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO675_022845	COG0583	DNA-binding transcription factor activity
IXO675_022850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO675_022865	COG0210	DNA helicase
IXO675_022880	COG0531	amino acid
IXO675_022885	COG1322	Protein conserved in bacteria
IXO675_022895	COG0386	Belongs to the glutathione peroxidase family
IXO675_022950	COG0793	Belongs to the peptidase S41A family
IXO675_022955	COG4942	peptidase
IXO675_022965	COG2234	aminopeptidase activity
IXO675_023010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO675_023015	COG0302	gtp cyclohydrolase
IXO675_023045	COG3039	Transposase
IXO675_023050	COG0477	Major facilitator Superfamily
IXO675_023070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO675_023095	COG3039	Transposase
IXO675_023150	COG1929	Belongs to the glycerate kinase type-1 family
IXO675_023155	COG2271	Major facilitator Superfamily
IXO675_023170	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO675_023175	COG0861	Integral membrane protein TerC family
IXO675_023185	COG0584	glycerophosphoryl diester phosphodiesterase
IXO675_023195	COG0671	phosphoesterase, PA-phosphatase related
IXO675_023205	COG0726	polysaccharide deacetylase
IXO675_023210	COG0706	membrane insertase activity