locus-tag	class	description
IXO685_0000040	COG2201	protein-glutamate methylesterase activity
IXO685_0000050	COG2801	Transposase and inactivated derivatives
IXO685_0000100	COG0322	excinuclease ABC activity
IXO685_0000110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO685_0000120	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO685_0000135	COG0811	peptide transport
IXO685_0000160	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO685_0000175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO685_0000190	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO685_0000205	COG0354	folic acid binding
IXO685_0000220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO685_0000230	COG0363	glucosamine-6-phosphate deaminase activity
IXO685_0000235	COG0129	dihydroxy-acid dehydratase activity
IXO685_0000240	COG0800	Aldolase
IXO685_0000280	COG5002	protein histidine kinase activity
IXO685_0000280	COG0784	Response regulator, receiver
IXO685_0000280	COG2205	protein histidine kinase activity
IXO685_0000305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO685_0000310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IXO685_0000315	COG0431	NADPH-dependent FMN reductase
IXO685_0000320	COG1393	Belongs to the ArsC family
IXO685_0000325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO685_0000340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO685_0000365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IXO685_0000385	COG1247	-acetyltransferase
IXO685_0000470	COG0386	Belongs to the glutathione peroxidase family
IXO685_0000555	COG2203	Gaf domain
IXO685_0000555	COG5001	Diguanylate cyclase
IXO685_0000555	COG4251	negative regulation of phosphorylation
IXO685_0000555	COG3706	GGDEF domain
IXO685_0000570	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO685_0000600	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO685_0000605	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO685_0000615	COG0617	tRNA 3'-terminal CCA addition
IXO685_0000625	COG1469	GTP cyclohydrolase I activity
IXO685_0000630	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO685_0000675	COG4566	intracellular signal transduction
IXO685_0000705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO685_0000710	COG0077	Prephenate dehydratase
IXO685_0000710	COG1605	Chorismate mutase
IXO685_0000720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO685_0000765	COG1228	amidohydrolase
IXO685_0000770	COG2986	histidine ammonia-lyase
IXO685_0000780	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO685_0000805	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO685_0000820	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO685_0000840	COG3115	cell septum assembly
IXO685_0000850	COG0359	binds to the 23S rRNA
IXO685_0000860	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO685_0000865	COG0316	Belongs to the HesB IscA family
IXO685_0000895	COG0288	reversible hydration of carbon dioxide
IXO685_0000930	COG2925	Exonuclease
IXO685_0000940	COG0667	Aldo Keto reductase
IXO685_0000965	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO685_0000965	COG0116	Belongs to the methyltransferase superfamily
IXO685_0001010	COG0494	nUDIX hydrolase
IXO685_0001025	COG1024	Enoyl-CoA hydratase
IXO685_0001035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO685_0001070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO685_0001075	COG0573	inorganic phosphate transmembrane transporter activity
IXO685_0001090	COG0704	Plays a role in the regulation of phosphate uptake
IXO685_0001100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO685_0001115	COG3328	transposase activity
IXO685_0001145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO685_0001150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO685_0001155	COG1862	Preprotein translocase
IXO685_0001160	COG0343	queuine tRNA-ribosyltransferase activity
IXO685_0001200	COG3039	Transposase
IXO685_0001285	COG3039	Transposase
IXO685_0001340	COG4771	TonB-dependent receptor
IXO685_0001350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO685_0001370	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO685_0001375	COG1360	Flagellar Motor Protein
IXO685_0001385	COG0835	chemotaxis
IXO685_0001395	COG0745	RESPONSE REGULATOR receiver
IXO685_0001420	COG0840	transmembrane signaling receptor activity
IXO685_0001430	COG0840	transmembrane signaling receptor activity
IXO685_0001440	COG0840	transmembrane signaling receptor activity
IXO685_0001450	COG0840	transmembrane signaling receptor activity
IXO685_0001455	COG0840	transmembrane signaling receptor activity
IXO685_0001460	COG0840	transmembrane signaling receptor activity
IXO685_0001465	COG0840	transmembrane signaling receptor activity
IXO685_0001480	COG0835	chemotaxis
IXO685_0001535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO685_0001565	COG0318	PFAM AMP-dependent synthetase and ligase
IXO685_0001570	COG1024	Enoyl-CoA hydratase
IXO685_0001575	COG0784	Response regulator, receiver
IXO685_0001575	COG2205	protein histidine kinase activity
IXO685_0001575	COG2198	Histidine kinase
IXO685_0001585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IXO685_0001650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO685_0001660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO685_0001665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO685_0001675	COG0505	Belongs to the CarA family
IXO685_0001680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO685_0001690	COG2258	MOSC domain
IXO685_0001695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO685_0001745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO685_0001765	COG0477	Major facilitator Superfamily
IXO685_0001775	COG1070	Carbohydrate kinase
IXO685_0001785	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO685_0001800	COG0800	Aldolase
IXO685_0001805	COG4948	Mandelate Racemase Muconate Lactonizing
IXO685_0001815	COG3734	2-keto-3-deoxy-galactonokinase
IXO685_0001820	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO685_0001830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO685_0001845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO685_0001850	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO685_0001860	COG0351	phosphomethylpyrimidine kinase
IXO685_0001890	COG0583	DNA-binding transcription factor activity
IXO685_0001895	COG1741	Belongs to the pirin family
IXO685_0001920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO685_0001925	COG0305	Participates in initiation and elongation during chromosome replication
IXO685_0001945	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO685_0001950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO685_0001955	COG2137	regulation of response to DNA damage stimulus
IXO685_0001960	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO685_0001975	COG1546	Belongs to the CinA family
IXO685_0001980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO685_0001990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO685_0001995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO685_0002005	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO685_0002010	COG1534	Rna-binding protein
IXO685_0002025	COG1238	metal cluster binding
IXO685_0002030	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO685_0002035	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO685_0002040	COG2840	Smr protein MutS2
IXO685_0002050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO685_0002060	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO685_0002065	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO685_0002070	COG0148	phosphopyruvate hydratase activity
IXO685_0002080	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO685_0002085	COG0504	CTP synthase activity
IXO685_0002115	COG0306	phosphate transporter
IXO685_0002125	COG1253	flavin adenine dinucleotide binding
IXO685_0002140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO685_0002150	COG0477	Major facilitator Superfamily
IXO685_0002160	COG1132	(ABC) transporter
IXO685_0002165	COG1136	(ABC) transporter
IXO685_0002180	COG0438	transferase activity, transferring glycosyl groups
IXO685_0002190	COG2264	protein methyltransferase activity
IXO685_0002220	COG2244	polysaccharide biosynthetic process
IXO685_0002270	COG1595	DNA-templated transcription, initiation
IXO685_0002285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO685_0002305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO685_0002365	COG2201	protein-glutamate methylesterase activity
IXO685_0002385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO685_0002390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO685_0002440	COG1858	cytochrome C peroxidase
IXO685_0002470	COG0515	serine threonine protein kinase
IXO685_0002475	COG0631	protein serine/threonine phosphatase activity
IXO685_0002585	COG3039	Transposase
IXO685_0002620	COG3039	Transposase
IXO685_0002625	COG3039	Transposase
IXO685_0002650	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IXO685_0002650	COG0316	Belongs to the HesB IscA family
IXO685_0002655	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO685_0002665	COG0428	transporter
IXO685_0002670	COG0428	transporter
IXO685_0002675	COG3064	Membrane
IXO685_0002685	COG1530	ribonuclease E activity
IXO685_0002700	COG1054	Belongs to the UPF0176 family
IXO685_0002720	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO685_0002755	COG3039	Transposase
IXO685_0002795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO685_0002795	COG1648	precorrin-2 dehydrogenase activity
IXO685_0002820	COG0746	molybdenum cofactor guanylyltransferase activity
IXO685_0002845	COG3039	Transposase
IXO685_0002905	COG4206	TonB-dependent receptor
IXO685_0002955	COG0531	amino acid
IXO685_0002970	COG0006	proline dipeptidase activity
IXO685_0002980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO685_0002995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO685_0003000	COG3938	Belongs to the proline racemase family
IXO685_0003010	COG0552	protein localization to endoplasmic reticulum
IXO685_0003030	COG0784	Response regulator, receiver
IXO685_0003030	COG4191	Histidine kinase
IXO685_0003120	COG3040	lipid binding
IXO685_0003160	COG0438	transferase activity, transferring glycosyl groups
IXO685_0003170	COG0438	transferase activity, transferring glycosyl groups
IXO685_0003175	COG0438	transferase activity, transferring glycosyl groups
IXO685_0003230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO685_0003235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IXO685_0003245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO685_0003285	COG0556	nucleotide-excision repair
IXO685_0003290	COG4969	Belongs to the N-Me-Phe pilin family
IXO685_0003360	COG4695	Portal protein
IXO685_0003405	COG3179	chitinase
IXO685_0003500	COG1192	Involved in chromosome partitioning
IXO685_0003610	COG1611	Belongs to the LOG family
IXO685_0003625	COG2095	MarC family integral membrane protein
IXO685_0003635	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO685_0003670	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO685_0003675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO685_0003695	COG0195	Participates in both transcription termination and antitermination
IXO685_0003700	COG0779	Required for maturation of 30S ribosomal subunits
IXO685_0003710	COG1007	ATP synthesis coupled electron transport
IXO685_0003740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO685_0003745	COG1034	ATP synthesis coupled electron transport
IXO685_0003750	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO685_0003755	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO685_0003760	COG0649	NAD binding
IXO685_0003765	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO685_0003775	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO685_0003790	COG0149	triose-phosphate isomerase activity
IXO685_0003840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO685_0003845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO685_0003850	COG0159	tryptophan synthase activity
IXO685_0003860	COG0133	tryptophan synthase activity
IXO685_0003870	COG0135	phosphoribosylanthranilate isomerase activity
IXO685_0003875	COG0101	tRNA pseudouridine synthase activity
IXO685_0003895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO685_0003900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO685_0003905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO685_0003910	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO685_0004035	COG3039	Transposase
IXO685_0004060	COG3179	chitinase
IXO685_0004115	COG1741	Belongs to the pirin family
IXO685_0004120	COG1966	Carbon starvation protein
IXO685_0004125	COG2879	small protein
IXO685_0004160	COG5001	Diguanylate cyclase
IXO685_0004160	COG4251	negative regulation of phosphorylation
IXO685_0004160	COG3706	GGDEF domain
IXO685_0004160	COG2203	Gaf domain
IXO685_0004165	COG0629	single-stranded DNA binding
IXO685_0004170	COG0142	geranyltranstransferase activity
IXO685_0004195	COG0527	aspartate kinase activity
IXO685_0004205	COG0384	phenazine biosynthesis protein PhzF
IXO685_0004215	COG1764	response to oxidative stress
IXO685_0004230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO685_0004235	COG1678	Uncharacterized ACR, COG1678
IXO685_0004245	COG0519	Catalyzes the synthesis of GMP from XMP
IXO685_0004275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO685_0004315	COG0693	protein deglycase activity
IXO685_0004335	COG1959	2 iron, 2 sulfur cluster binding
IXO685_0004340	COG0719	Fe-S assembly protein
IXO685_0004345	COG0396	ATPase activity
IXO685_0004350	COG0719	Fe-S assembly protein
IXO685_0004355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO685_0004370	COG2146	nitrite reductase [NAD(P)H] activity
IXO685_0004405	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO685_0004420	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO685_0004430	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO685_0004435	COG0174	glutamine synthetase
IXO685_0004440	COG3328	transposase activity
IXO685_0004465	COG0326	Molecular chaperone. Has ATPase activity
IXO685_0004470	COG2207	Transcriptional regulator
IXO685_0004490	COG0657	acetylesterase activity
IXO685_0004490	COG2755	lipolytic protein G-D-S-L family
IXO685_0004515	COG0488	(ABC) transporter
IXO685_0004540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO685_0004540	COG4651	solute:proton antiporter activity
IXO685_0004555	COG4772	TonB-dependent receptor
IXO685_0004565	COG4264	IucA IucC family
IXO685_0004570	COG2814	Major facilitator Superfamily
IXO685_0004580	COG0019	diaminopimelate decarboxylase activity
IXO685_0004640	COG4206	TonB-dependent receptor
IXO685_0004675	COG0542	response to heat
IXO685_0004700	COG3039	Transposase
IXO685_0004715	COG0534	Mate efflux family protein
IXO685_0004730	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO685_0004735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO685_0004740	COG0228	four-way junction DNA binding
IXO685_0004760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO685_0004780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO685_0004825	COG1555	photosystem II stabilization
IXO685_0004830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO685_0004845	COG3178	'Phosphotransferase
IXO685_0004850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO685_0004860	COG0628	permease
IXO685_0004870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO685_0004885	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO685_0004905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO685_0004910	COG0271	Belongs to the BolA IbaG family
IXO685_0004920	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO685_0004930	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO685_0004935	COG1137	ATPase activity
IXO685_0004950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO685_0004955	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO685_0004960	COG1660	Displays ATPase and GTPase activities
IXO685_0004975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO685_0004980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO685_0004985	COG2239	Acts as a magnesium transporter
IXO685_0004995	COG1294	oxidase, subunit
IXO685_0005000	COG1271	oxidase subunit
IXO685_0005015	COG1113	amino acid transport
IXO685_0005030	COG2197	response regulator
IXO685_0005035	COG0531	amino acid
IXO685_0005090	COG0754	glutathionylspermidine amidase activity
IXO685_0005115	COG1842	Phage shock protein A
IXO685_0005130	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO685_0005220	COG2201	protein-glutamate methylesterase activity
IXO685_0005245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO685_0005295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO685_0005300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO685_0005325	COG3039	Transposase
IXO685_0005350	COG0745	RESPONSE REGULATOR receiver
IXO685_0005355	COG2205	protein histidine kinase activity
IXO685_0005375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO685_0005415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO685_0005415	COG3453	Protein conserved in bacteria
IXO685_0005420	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO685_0005425	COG4149	molybdate abc transporter
IXO685_0005430	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO685_0005450	COG0642	Histidine kinase
IXO685_0005465	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_0005475	COG1022	Amp-dependent synthetase and ligase
IXO685_0005500	COG1376	ErfK ybiS ycfS ynhG family protein
IXO685_0005505	COG0739	heme binding
IXO685_0005515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO685_0005520	COG1301	dicarboxylic acid transport
IXO685_0005540	COG2304	oxidoreductase activity
IXO685_0005560	COG0714	Associated with various cellular activities
IXO685_0005610	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO685_0005635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO685_0005645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO685_0005670	COG1561	YicC-like family, N-terminal region
IXO685_0005675	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO685_0005690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO685_0005725	COG0006	proline dipeptidase activity
IXO685_0005750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO685_0005760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO685_0005770	COG2912	Transglutaminase-like superfamily
IXO685_0005775	COG1773	rubredoxin
IXO685_0005780	COG0352	thiamine-phosphate diphosphorylase activity
IXO685_0005840	COG0281	malic enzyme
IXO685_0005840	COG0280	phosphate acetyltransferase
IXO685_0005860	COG4191	Histidine kinase
IXO685_0005875	COG0583	DNA-binding transcription factor activity
IXO685_0005890	COG2197	response regulator
IXO685_0005900	COG0642	Histidine kinase
IXO685_0005915	COG2851	Citrate transporter
IXO685_0005920	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_0005925	COG1609	Transcriptional regulator
IXO685_0005935	COG2211	Major facilitator Superfamily
IXO685_0005985	COG0726	polysaccharide deacetylase
IXO685_0005990	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO685_0006040	COG0242	peptide deformylase activity
IXO685_0006060	COG0714	Associated with various cellular activities
IXO685_0006080	COG0537	adenosine 5'-monophosphoramidase activity
IXO685_0006110	COG0314	molybdopterin synthase activity
IXO685_0006115	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO685_0006120	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO685_0006130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO685_0006135	COG1234	tRNA 3'-trailer cleavage
IXO685_0006140	COG3642	lipopolysaccharide core region biosynthetic process
IXO685_0006145	COG0859	PFAM glycosyl transferase family 9
IXO685_0006155	COG0582	viral genome integration into host DNA
IXO685_0006210	COG0631	protein serine/threonine phosphatase activity
IXO685_0006220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO685_0006245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO685_0006285	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO685_0006335	COG0473	3-isopropylmalate dehydrogenase activity
IXO685_0006360	COG4783	chaperone-mediated protein folding
IXO685_0006375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO685_0006385	COG0438	transferase activity, transferring glycosyl groups
IXO685_0006390	COG0671	phosphoesterase, PA-phosphatase related
IXO685_0006395	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO685_0006415	COG2833	Protein of unknown function (DUF455)
IXO685_0006435	COG0285	dihydrofolate synthase activity
IXO685_0006445	COG0588	phosphoglycerate mutase activity
IXO685_0006480	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO685_0006485	COG4208	sulfate ABC transporter
IXO685_0006490	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO685_0006495	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO685_0006500	COG0156	8-amino-7-oxononanoate synthase activity
IXO685_0006525	COG0604	alcohol dehydrogenase
IXO685_0006530	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO685_0006530	COG1902	pentaerythritol trinitrate reductase activity
IXO685_0006560	COG0584	glycerophosphoryl diester phosphodiesterase
IXO685_0006580	COG3039	Transposase
IXO685_0006605	COG0625	glutathione transferase activity
IXO685_0006610	COG0039	L-malate dehydrogenase activity
IXO685_0006615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO685_0006620	COG1217	gtp-binding protein TYPA
IXO685_0006640	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO685_0006790	COG3781	membrane
IXO685_0006800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO685_0006830	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO685_0006850	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO685_0006875	COG3710	Transcriptional regulator
IXO685_0006880	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO685_0006890	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO685_0006925	COG0066	3-isopropylmalate dehydratase activity
IXO685_0006930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO685_0006960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO685_0006965	COG1538	Outer membrane efflux protein
IXO685_0006970	COG1519	Transferase
IXO685_0006975	COG1560	Kdo2-lipid A biosynthetic process
IXO685_0007025	COG0308	aminopeptidase N
IXO685_0007030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO685_0007040	COG0330	HflC and HflK could
IXO685_0007045	COG0330	HflC and HflK could
IXO685_0007065	COG0678	peroxiredoxin activity
IXO685_0007075	COG2826	transposase and inactivated derivatives, IS30 family
IXO685_0007105	COG3039	Transposase
IXO685_0007150	COG3829	transcription factor binding
IXO685_0007180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO685_0007185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO685_0007195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO685_0007200	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_0007225	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO685_0007265	COG1518	maintenance of DNA repeat elements
IXO685_0007270	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO685_0007320	COG2188	Transcriptional regulator
IXO685_0007335	COG1450	Type ii and iii secretion system protein
IXO685_0007350	COG3166	PFAM Fimbrial assembly family protein
IXO685_0007355	COG3156	type II secretion system protein K
IXO685_0007360	COG4795	General secretion pathway protein
IXO685_0007365	COG2165	general secretion pathway protein
IXO685_0007370	COG4970	Tfp pilus assembly protein FimT
IXO685_0007375	COG2165	general secretion pathway protein
IXO685_0007380	COG1459	type II secretion system
IXO685_0007390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO685_0007400	COG1404	Belongs to the peptidase S8 family
IXO685_0007410	COG5295	Hep Hag repeat protein
IXO685_0007420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO685_0007425	COG4974	Belongs to the 'phage' integrase family
IXO685_0007440	COG0795	lipopolysaccharide-transporting ATPase activity
IXO685_0007450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO685_0007465	COG0525	valine-tRNA ligase activity
IXO685_0007495	COG3039	Transposase
IXO685_0007520	COG3039	Transposase
IXO685_0007550	COG1183	phosphatidylcholine synthase activity
IXO685_0007560	COG0442	prolyl-tRNA aminoacylation
IXO685_0007575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO685_0007580	COG1127	ABC transporter
IXO685_0007585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO685_0007585	COG3218	ABC-type transport auxiliary lipoprotein component
IXO685_0007620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO685_0007625	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO685_0007625	COG0662	Cupin 2, conserved barrel domain protein
IXO685_0007650	COG2086	electron transfer activity
IXO685_0007665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO685_0007665	COG0546	phosphoglycolate phosphatase activity
IXO685_0007670	COG0277	FAD linked oxidase domain protein
IXO685_0007685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO685_0007690	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IXO685_0007725	COG0438	transferase activity, transferring glycosyl groups
IXO685_0007725	COG1216	Glycosyl transferase, family 2
IXO685_0007745	COG0626	cystathionine gamma-synthase activity
IXO685_0007775	COG0625	glutathione transferase activity
IXO685_0007785	COG0513	Belongs to the DEAD box helicase family
IXO685_0007790	COG0720	synthase
IXO685_0007800	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO685_0007805	COG1956	GAF domain-containing protein
IXO685_0007840	COG0339	signal peptide processing
IXO685_0007890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO685_0007895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO685_0007950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO685_0007955	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO685_0007960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO685_0007970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO685_0007980	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO685_0008000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO685_0008010	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO685_0008040	COG2011	ABC-type metal ion transport system permease component
IXO685_0008050	COG0697	spore germination
IXO685_0008090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO685_0008095	COG1187	pseudouridine synthase activity
IXO685_0008100	COG2813	Specifically methylates the guanine in position
IXO685_0008130	COG2202	Pas domain
IXO685_0008130	COG2205	protein histidine kinase activity
IXO685_0008155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO685_0008205	COG0745	RESPONSE REGULATOR receiver
IXO685_0008220	COG1404	Belongs to the peptidase S8 family
IXO685_0008240	COG0842	Transport permease protein
IXO685_0008245	COG1131	(ABC) transporter
IXO685_0008250	COG0025	NhaP-type Na H and K H
IXO685_0008265	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO685_0008275	COG1573	uracil-dna glycosylase
IXO685_0008285	COG3384	dioxygenase
IXO685_0008300	COG0667	Aldo Keto reductase
IXO685_0008315	COG3590	peptidase
IXO685_0008335	COG0531	amino acid
IXO685_0008350	COG2972	Histidine kinase
IXO685_0008400	COG2204	response regulator
IXO685_0008410	COG1271	oxidase subunit
IXO685_0008415	COG1294	oxidase, subunit
IXO685_0008435	COG3039	Transposase
IXO685_0008495	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO685_0008510	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO685_0008560	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO685_0008565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO685_0008570	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO685_0008580	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO685_0008585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO685_0008600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO685_0008660	COG3039	Transposase
IXO685_0008680	COG3328	transposase activity
IXO685_0008685	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO685_0008685	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO685_0008695	COG1473	amidohydrolase
IXO685_0008700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO685_0008705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO685_0008715	COG5383	Protein conserved in bacteria
IXO685_0008740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO685_0008745	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO685_0008760	COG0028	Belongs to the TPP enzyme family
IXO685_0008765	COG4191	Histidine kinase
IXO685_0008790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO685_0008805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO685_0008810	COG3177	Filamentation induced by cAMP protein fic
IXO685_0008825	COG0596	Alpha beta hydrolase
IXO685_0008830	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO685_0008835	COG0318	PFAM AMP-dependent synthetase and ligase
IXO685_0008840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO685_0008870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO685_0008880	COG0129	dihydroxy-acid dehydratase activity
IXO685_0008900	COG3039	Transposase
IXO685_0008910	COG0408	coproporphyrinogen oxidase activity
IXO685_0009010	COG2353	YceI-like domain
IXO685_0009040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO685_0009055	COG3386	PFAM SMP-30 Gluconolaconase
IXO685_0009100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO685_0009120	COG0459	protein refolding
IXO685_0009145	COG1252	NADH dehydrogenase
IXO685_0009155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO685_0009160	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO685_0009165	COG2201	protein-glutamate methylesterase activity
IXO685_0009170	COG2177	Part of the ABC transporter FtsEX involved in
IXO685_0009175	COG2884	Cell division ATP-binding protein ftsE
IXO685_0009185	COG3118	belongs to the thioredoxin family
IXO685_0009190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO685_0009205	COG0729	surface antigen
IXO685_0009210	COG2911	Protein conserved in bacteria
IXO685_0009245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO685_0009260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO685_0009280	COG3039	Transposase
IXO685_0009315	COG1733	regulation of RNA biosynthetic process
IXO685_0009320	COG0702	epimerase
IXO685_0009350	COG0583	DNA-binding transcription factor activity
IXO685_0009355	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO685_0009375	COG0745	RESPONSE REGULATOR receiver
IXO685_0009405	COG1902	pentaerythritol trinitrate reductase activity
IXO685_0009410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO685_0009435	COG0583	DNA-binding transcription factor activity
IXO685_0009450	COG0084	hydrolase, TatD family'
IXO685_0009495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO685_0009515	COG2072	flavoprotein involved in K transport
IXO685_0009565	COG4770	biotin carboxylase activity
IXO685_0009570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO685_0009575	COG1960	acyl-CoA dehydrogenase activity
IXO685_0009625	COG0523	cobalamin synthesis protein
IXO685_0009635	COG0697	spore germination
IXO685_0009645	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO685_0009665	COG4771	TonB-dependent receptor
IXO685_0009670	COG0457	Tetratricopeptide repeat
IXO685_0009680	COG0752	glycyl-tRNA synthetase alpha subunit
IXO685_0009685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO685_0009700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO685_0009700	COG0519	Catalyzes the synthesis of GMP from XMP
IXO685_0009710	COG0805	protein transport
IXO685_0009720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO685_0009730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO685_0009755	COG2974	May be involved in recombination
IXO685_0009760	COG0037	tRNA processing
IXO685_0009775	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO685_0009785	COG4948	Mandelate Racemase Muconate Lactonizing
IXO685_0009795	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO685_0009800	COG0246	Mannitol dehydrogenase
IXO685_0009825	COG3693	PFAM glycoside hydrolase, family 10
IXO685_0009845	COG2211	Major facilitator Superfamily
IXO685_0009885	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IXO685_0009930	COG1846	Transcriptional regulator
IXO685_0009935	COG1764	response to oxidative stress
IXO685_0010010	COG3549	Plasmid maintenance system killer
IXO685_0010020	COG1074	ATP-dependent DNA helicase activity
IXO685_0010025	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO685_0010035	COG1196	nuclear chromosome segregation
IXO685_0010070	COG2032	superoxide dismutase activity
IXO685_0010075	COG2032	superoxide dismutase activity
IXO685_0010080	COG2204	response regulator
IXO685_0010085	COG3852	Histidine kinase
IXO685_0010090	COG0004	ammonium transporteR
IXO685_0010095	COG0347	Belongs to the P(II) protein family
IXO685_0010100	COG0174	glutamine synthetase
IXO685_0010105	COG1968	undecaprenyl-diphosphatase activity
IXO685_0010150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO685_0010160	COG2062	phosphohistidine phosphatase, SixA
IXO685_0010165	COG0489	protein tyrosine kinase activity
IXO685_0010190	COG1396	sequence-specific DNA binding
IXO685_0010195	COG3550	peptidyl-serine autophosphorylation
IXO685_0010200	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO685_0010205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO685_0010220	COG1125	glycine betaine transport
IXO685_0010220	COG0517	IMP dehydrogenase activity
IXO685_0010235	COG1119	ATPase activity
IXO685_0010245	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO685_0010290	COG2937	Belongs to the GPAT DAPAT family
IXO685_0010325	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO685_0010330	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO685_0010335	COG3132	Protein of unknown function, DUF480
IXO685_0010350	COG0210	DNA helicase
IXO685_0010365	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO685_0010390	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_0010415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO685_0010465	COG1166	arginine decarboxylase activity
IXO685_0010470	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO685_0010515	COG0606	chelatase, subunit chli
IXO685_0010555	COG0366	Alpha amylase catalytic
IXO685_0010560	COG0366	Alpha amylase catalytic
IXO685_0010590	COG1609	Transcriptional regulator
IXO685_0010635	COG0493	'glutamate synthase
IXO685_0010640	COG0067	glutamate synthase
IXO685_0010640	COG0069	glutamate synthase activity
IXO685_0010640	COG0070	glutamate synthase
IXO685_0010700	COG1111	helicase
IXO685_0010700	COG1205	dead DEAH box helicase
IXO685_0010705	COG1272	protein, Hemolysin III
IXO685_0010745	COG1136	(ABC) transporter
IXO685_0010795	COG1136	(ABC) transporter
IXO685_0010840	COG3039	Transposase
IXO685_0010845	COG0513	Belongs to the DEAD box helicase family
IXO685_0010925	COG1858	cytochrome C peroxidase
IXO685_0010940	COG0702	epimerase
IXO685_0010965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO685_0010985	COG1649	PFAM Uncharacterised BCR, COG1649
IXO685_0010990	COG2354	Protein conserved in bacteria
IXO685_0010995	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO685_0011010	COG1511	domain protein
IXO685_0011010	COG3264	Mechanosensitive ion channel
IXO685_0011090	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO685_0011200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO685_0011210	COG0642	Histidine kinase
IXO685_0011220	COG1090	epimerase
IXO685_0011230	COG3039	Transposase
IXO685_0011255	COG2826	transposase and inactivated derivatives, IS30 family
IXO685_0011350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO685_0011360	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO685_0011380	COG1304	FMN binding
IXO685_0011385	COG3039	Transposase
IXO685_0011400	COG4772	TonB-dependent receptor
IXO685_0011410	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO685_0011420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO685_0011460	COG0501	Belongs to the peptidase M48B family
IXO685_0011470	COG0187	DNA topoisomerase II activity
IXO685_0011485	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO685_0011500	COG0706	membrane insertase activity
IXO685_0011520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IXO685_0011525	COG0671	phosphoesterase, PA-phosphatase related
IXO685_0011535	COG0584	glycerophosphoryl diester phosphodiesterase
IXO685_0011545	COG0861	Integral membrane protein TerC family
IXO685_0011550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO685_0011565	COG2271	Major facilitator Superfamily
IXO685_0011570	COG1929	Belongs to the glycerate kinase type-1 family
IXO685_0011600	COG1192	Involved in chromosome partitioning
IXO685_0011665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO685_0011680	COG0477	Major facilitator Superfamily
IXO685_0011700	COG0302	gtp cyclohydrolase
IXO685_0011705	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO685_0011750	COG2234	aminopeptidase activity
IXO685_0011760	COG4942	peptidase
IXO685_0011765	COG0793	Belongs to the peptidase S41A family
IXO685_0011815	COG0386	Belongs to the glutathione peroxidase family
IXO685_0011825	COG1322	Protein conserved in bacteria
IXO685_0011835	COG0531	amino acid
IXO685_0011850	COG0210	DNA helicase
IXO685_0011865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO685_0011870	COG0583	DNA-binding transcription factor activity
IXO685_0011875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO685_0011885	COG2159	amidohydrolase
IXO685_0011910	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO685_0011915	COG3540	Alkaline phosphatase
IXO685_0011925	COG2091	lysine biosynthetic process via aminoadipic acid
IXO685_0011940	COG0708	Exodeoxyribonuclease III
IXO685_0011955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO685_0011960	COG3162	membrane
IXO685_0012000	COG3507	Belongs to the glycosyl hydrolase 43 family
IXO685_0012020	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_0012025	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO685_0012030	COG4948	Mandelate Racemase Muconate Lactonizing
IXO685_0012035	COG4807	Protein conserved in bacteria
IXO685_0012040	COG1643	Atp-dependent helicase
IXO685_0012050	COG1187	pseudouridine synthase activity
IXO685_0012060	COG0667	Aldo Keto reductase
IXO685_0012065	COG2130	NADP-dependent
IXO685_0012070	COG0656	L-ascorbic acid biosynthetic process
IXO685_0012110	COG3186	Phenylalanine-4-hydroxylase
IXO685_0012115	COG1522	sequence-specific DNA binding
IXO685_0012165	COG1064	alcohol dehydrogenase
IXO685_0012170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO685_0012180	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO685_0012190	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO685_0012210	COG0676	glucose-6-phosphate 1-epimerase activity
IXO685_0012275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO685_0012300	COG2853	Lipoprotein
IXO685_0012315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO685_0012320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO685_0012325	COG1127	ABC transporter
IXO685_0012425	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO685_0012430	COG3265	gluconokinase activity
IXO685_0012435	COG2211	Major facilitator Superfamily
IXO685_0012440	COG3459	Glycosyltransferase 36 associated
IXO685_0012450	COG2205	protein histidine kinase activity
IXO685_0012465	COG1414	Transcriptional regulator
IXO685_0012470	COG0738	Major facilitator superfamily
IXO685_0012475	COG3254	rhamnose metabolic process
IXO685_0012505	COG0339	signal peptide processing
IXO685_0012535	COG0564	pseudouridine synthase activity
IXO685_0012545	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO685_0012555	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO685_0012655	COG0842	Transport permease protein
IXO685_0012660	COG1131	(ABC) transporter
IXO685_0012690	COG1476	TRANSCRIPTIONal
IXO685_0012700	COG4555	ABC transporter
IXO685_0012735	COG0625	glutathione transferase activity
IXO685_0012780	COG0583	DNA-binding transcription factor activity
IXO685_0012820	COG1199	ATP-dependent helicase activity
IXO685_0012835	COG1566	PFAM secretion protein HlyD family protein
IXO685_0012860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO685_0012900	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO685_0012900	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO685_0012905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO685_0012920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO685_0012955	COG3237	CsbD-like
IXO685_0012960	COG0180	Tryptophanyl-tRNA synthetase
IXO685_0012965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO685_0013015	COG0753	catalase activity
IXO685_0013020	COG1595	DNA-templated transcription, initiation
IXO685_0013030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO685_0013040	COG0628	permease
IXO685_0013050	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO685_0013055	COG1040	competence protein
IXO685_0013060	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO685_0013065	COG0156	8-amino-7-oxononanoate synthase activity
IXO685_0013075	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_0013090	COG0463	Glycosyl transferase, family 2
IXO685_0013100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO685_0013105	COG3100	YcgL domain-containing protein
IXO685_0013120	COG3387	PFAM Glycoside hydrolase 15-related
IXO685_0013125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO685_0013140	COG2239	Acts as a magnesium transporter
IXO685_0013150	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO685_0013150	COG1042	CoA-binding domain protein
IXO685_0013150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO685_0013160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO685_0013165	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO685_0013205	COG3485	protocatechuate 3,4-dioxygenase
IXO685_0013210	COG3485	protocatechuate 3,4-dioxygenase
IXO685_0013225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO685_0013230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO685_0013255	COG4221	oxidoreductase activity
IXO685_0013280	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO685_0013305	COG0463	Glycosyl transferase, family 2
IXO685_0013320	COG1475	DNA binding
IXO685_0013325	COG1192	Involved in chromosome partitioning
IXO685_0013340	COG0708	Exodeoxyribonuclease III
IXO685_0013345	COG2211	Major facilitator Superfamily
IXO685_0013360	COG0739	heme binding
IXO685_0013405	COG0745	RESPONSE REGULATOR receiver
IXO685_0013445	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO685_0013460	COG2814	Major facilitator Superfamily
IXO685_0013475	COG1289	transmembrane transporter activity
IXO685_0013495	COG0151	Belongs to the GarS family
IXO685_0013505	COG0419	ATPase involved in DNA repair
IXO685_0013520	COG2267	carboxylic ester hydrolase activity
IXO685_0013525	COG2267	carboxylic ester hydrolase activity
IXO685_0013555	COG2831	hemolysin activation secretion protein
IXO685_0013560	COG3210	domain, Protein
IXO685_0013590	COG3210	domain, Protein
IXO685_0013630	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO685_0013675	COG0439	Biotin carboxylase
IXO685_0013685	COG0511	ligase activity, forming carbon-carbon bonds
IXO685_0013690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO685_0013700	COG1324	tolerance protein
IXO685_0013740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO685_0013760	COG0534	Mate efflux family protein
IXO685_0013765	COG0616	signal peptide processing
IXO685_0013775	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_0013790	COG0009	L-threonylcarbamoyladenylate synthase
IXO685_0013795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO685_0013795	COG1754	DNA topoisomerase type I activity
IXO685_0013810	COG2922	Belongs to the Smg family
IXO685_0013815	COG0758	DNA mediated transformation
IXO685_0013820	COG1652	LysM domain
IXO685_0013825	COG0242	peptide deformylase activity
IXO685_0013830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO685_0013835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO685_0013835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO685_0013885	COG1560	Kdo2-lipid A biosynthetic process
IXO685_0013895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO685_0013950	COG3039	Transposase
IXO685_0013995	COG0358	DNA primase activity
IXO685_0014000	COG1295	ribonuclease BN
IXO685_0014015	COG1610	YqeY-like protein
IXO685_0014025	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO685_0014030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO685_0014075	COG2133	pyrroloquinoline quinone binding
IXO685_0014080	COG4682	membrane
IXO685_0014105	COG0531	amino acid
IXO685_0014130	COG4948	Mandelate Racemase Muconate Lactonizing
IXO685_0014140	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO685_0014145	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO685_0014220	COG3039	Transposase
IXO685_0014265	COG0183	Belongs to the thiolase family
IXO685_0014300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IXO685_0014310	COG3483	tryptophan 2,3-dioxygenase activity
IXO685_0014315	COG3104	oligopeptide transport
IXO685_0014335	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO685_0014345	COG1320	monovalent cation:proton antiporter activity
IXO685_0014350	COG2212	antiporter activity
IXO685_0014360	COG0651	ATP synthesis coupled electron transport
IXO685_0014365	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO685_0014370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO685_0014370	COG2111	Na H antiporter
IXO685_0014420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO685_0014430	COG0456	acetyltransferase
IXO685_0014460	COG4221	oxidoreductase activity
IXO685_0014520	COG0697	spore germination
IXO685_0014525	COG4305	rare lipoprotein A
IXO685_0014530	COG5297	Belongs to the glycosyl hydrolase family 6
IXO685_0014540	COG1113	amino acid transport
IXO685_0014550	COG0598	Magnesium transport protein CorA
IXO685_0014570	COG3039	Transposase
IXO685_0014625	COG0840	transmembrane signaling receptor activity
IXO685_0014635	COG5297	Belongs to the glycosyl hydrolase family 6
IXO685_0014635	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO685_0014640	COG0659	secondary active sulfate transmembrane transporter activity
IXO685_0014685	COG3275	phosphorelay sensor kinase activity
IXO685_0014695	COG0181	hydroxymethylbilane synthase activity
IXO685_0014720	COG1505	serine-type exopeptidase activity
IXO685_0014735	COG0436	Aminotransferase
IXO685_0014765	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO685_0014795	COG0308	aminopeptidase N
IXO685_0014800	COG2199	diguanylate cyclase activity
IXO685_0014850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO685_0014855	COG1077	Cell shape determining protein MreB Mrl
IXO685_0014860	COG1792	Involved in formation and maintenance of cell shape
IXO685_0014875	COG0772	Belongs to the SEDS family
IXO685_0014905	COG3039	Transposase
IXO685_0014940	COG2951	lytic endotransglycosylase activity
IXO685_0014945	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO685_0014950	COG1686	Belongs to the peptidase S11 family
IXO685_0014960	COG2921	Belongs to the UPF0250 family
IXO685_0014985	COG1051	belongs to the nudix hydrolase family
IXO685_0014985	COG1056	cytidyltransferase-related domain
IXO685_0015020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO685_0015025	COG0673	inositol 2-dehydrogenase activity
IXO685_0015030	COG2823	Periplasmic or secreted lipoprotein
IXO685_0015035	COG4251	negative regulation of phosphorylation
IXO685_0015040	COG0784	Response regulator, receiver
IXO685_0015045	COG4191	Histidine kinase
IXO685_0015050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO685_0015100	COG3250	beta-galactosidase activity
IXO685_0015115	COG2188	Transcriptional regulator
IXO685_0015125	COG1609	Transcriptional regulator
IXO685_0015130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO685_0015135	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO685_0015145	COG1215	transferase activity, transferring glycosyl groups
IXO685_0015150	COG1649	PFAM Uncharacterised BCR, COG1649
IXO685_0015150	COG0726	polysaccharide deacetylase
IXO685_0015250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO685_0015255	COG3039	Transposase
IXO685_0015300	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO685_0015315	COG2205	protein histidine kinase activity
IXO685_0015350	COG2205	protein histidine kinase activity
IXO685_0015400	COG0488	(ABC) transporter
IXO685_0015420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO685_0015440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO685_0015440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO685_0015460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO685_0015465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO685_0015470	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO685_0015490	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO685_0015495	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO685_0015505	COG2205	protein histidine kinase activity
IXO685_0015510	COG0745	RESPONSE REGULATOR receiver
IXO685_0015515	COG0277	FAD linked oxidase domain protein
IXO685_0015520	COG1988	membrane-bound metal-dependent
IXO685_0015525	COG0792	nuclease activity
IXO685_0015560	COG0275	rRNA processing
IXO685_0015565	COG3116	cell division
IXO685_0015580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO685_0015585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO685_0015600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO685_0015605	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO685_0015610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO685_0015625	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO685_0015635	COG1388	LysM domain
IXO685_0015635	COG4942	peptidase
IXO685_0015640	COG0653	protein targeting
IXO685_0015650	COG0494	nUDIX hydrolase
IXO685_0015665	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO685_0015675	COG0604	alcohol dehydrogenase
IXO685_0015675	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_0015675	COG3321	synthase
IXO685_0015720	COG2226	methyltransferase
IXO685_0015725	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO685_0015760	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO685_0015775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO685_0015785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO685_0015790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO685_0015800	COG0667	Aldo Keto reductase
IXO685_0015850	COG2175	clavaminate synthase activity
IXO685_0015860	COG4181	ATPase activity
IXO685_0015875	COG0642	Histidine kinase
IXO685_0015900	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO685_0015920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO685_0015940	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IXO685_0015945	COG2967	ApaG domain
IXO685_0015950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO685_0015960	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO685_0015975	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO685_0015980	COG2096	Adenosyltransferase
IXO685_0015990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO685_0015995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO685_0016035	COG0583	DNA-binding transcription factor activity
IXO685_0016040	COG0318	PFAM AMP-dependent synthetase and ligase
IXO685_0016050	COG1024	Enoyl-CoA hydratase
IXO685_0016070	COG3386	PFAM SMP-30 Gluconolaconase
IXO685_0016175	COG2197	response regulator
IXO685_0016220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO685_0016225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO685_0016230	COG0583	DNA-binding transcription factor activity
IXO685_0016235	COG3634	alkyl hydroperoxide reductase activity
IXO685_0016245	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO685_0016285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO685_0016285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO685_0016300	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO685_0016325	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO685_0016350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO685_0016360	COG1404	Belongs to the peptidase S8 family
IXO685_0016365	COG1404	Belongs to the peptidase S8 family
IXO685_0016370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO685_0016400	COG1295	ribonuclease BN
IXO685_0016405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO685_0016425	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO685_0016435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO685_0016440	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO685_0016450	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO685_0016465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO685_0016475	COG0193	aminoacyl-tRNA hydrolase activity
IXO685_0016480	COG0012	GTP binding
IXO685_0016510	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO685_0016515	COG0250	Participates in transcription elongation, termination and antitermination
IXO685_0016520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO685_0016530	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO685_0016535	COG0222	ribosome binding
IXO685_0016540	COG0085	RNA polymerase activity
IXO685_0016545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO685_0016550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO685_0016555	COG0049	tRNA binding
IXO685_0016575	COG0051	transcription antitermination factor activity, RNA binding
IXO685_0016580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO685_0016585	COG0088	Forms part of the polypeptide exit tunnel
IXO685_0016590	COG0089	rRNA binding
IXO685_0016605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO685_0016615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO685_0016620	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO685_0016625	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO685_0016630	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO685_0016635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IXO685_0016640	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO685_0016660	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IXO685_0016670	COG1841	ribosomal large subunit assembly
IXO685_0016680	COG0201	protein transport
IXO685_0016690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO685_0016695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO685_0016705	COG0203	ribosomal protein L17
IXO685_0016765	COG3551	Protein conserved in bacteria
IXO685_0016795	COG2194	sulfuric ester hydrolase activity
IXO685_0016805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO685_0016810	COG0745	RESPONSE REGULATOR receiver
IXO685_0016815	COG0642	Histidine kinase
IXO685_0016825	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO685_0016830	COG2894	cell division
IXO685_0016850	COG4585	Histidine kinase
IXO685_0016855	COG2197	response regulator
IXO685_0016870	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO685_0016900	COG2963	transposase activity
IXO685_0017010	COG3039	Transposase
IXO685_0017070	COG1741	Belongs to the pirin family
IXO685_0017080	COG1515	deoxyribonuclease V activity
IXO685_0017085	COG0588	phosphoglycerate mutase activity
IXO685_0017100	COG3590	peptidase
IXO685_0017115	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO685_0017120	COG2199	diguanylate cyclase activity
IXO685_0017120	COG2200	EAL domain
IXO685_0017120	COG2202	Pas domain
IXO685_0017125	COG0835	chemotaxis
IXO685_0017130	COG0840	transmembrane signaling receptor activity
IXO685_0017135	COG2198	Histidine kinase
IXO685_0017135	COG0643	Histidine kinase
IXO685_0017150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO685_0017160	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO685_0017195	COG3039	Transposase
IXO685_0017245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO685_0017250	COG0735	belongs to the Fur family
IXO685_0017310	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO685_0017315	COG0084	hydrolase, TatD family'
IXO685_0017330	COG1960	acyl-CoA dehydrogenase activity
IXO685_0017345	COG0367	asparagine synthase
IXO685_0017355	COG0305	Participates in initiation and elongation during chromosome replication
IXO685_0017360	COG0415	Belongs to the DNA photolyase family
IXO685_0017375	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_0017490	COG5002	protein histidine kinase activity
IXO685_0017490	COG5001	Diguanylate cyclase
IXO685_0017495	COG1187	pseudouridine synthase activity
IXO685_0017515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO685_0017525	COG0475	glutathione-regulated potassium exporter activity
IXO685_0017530	COG5000	phosphorelay sensor kinase activity
IXO685_0017530	COG5002	protein histidine kinase activity
IXO685_0017535	COG0745	RESPONSE REGULATOR receiver
IXO685_0017565	COG1132	(ABC) transporter
IXO685_0017615	COG3039	Transposase
IXO685_0017630	COG3209	COG3209 Rhs family protein
IXO685_0017645	COG3039	Transposase
IXO685_0017680	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO685_0017690	COG4969	Belongs to the N-Me-Phe pilin family
IXO685_0017695	COG2194	sulfuric ester hydrolase activity
IXO685_0017735	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO685_0017740	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO685_0017750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO685_0017750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO685_0017755	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO685_0017760	COG0564	pseudouridine synthase activity
IXO685_0017785	COG3387	PFAM Glycoside hydrolase 15-related
IXO685_0017790	COG1877	trehalose-phosphatase activity
IXO685_0017830	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO685_0017845	COG1595	DNA-templated transcription, initiation
IXO685_0017855	COG1946	Acyl-CoA thioesterase
IXO685_0017870	COG0824	Thioesterase
IXO685_0017875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO685_0017885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO685_0017890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO685_0017895	COG0268	Binds directly to 16S ribosomal RNA
IXO685_0017900	COG0728	peptidoglycan biosynthetic process
IXO685_0017905	COG0196	riboflavin kinase activity
IXO685_0017915	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO685_0017920	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO685_0017935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO685_0017940	COG1845	cytochrome c oxidase, subunit III
IXO685_0017945	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO685_0017980	COG3039	Transposase
IXO685_0018010	COG3039	Transposase
IXO685_0018015	COG3209	COG3209 Rhs family protein
IXO685_0018040	COG3039	Transposase
IXO685_0018065	COG3039	Transposase
IXO685_0018120	COG3118	belongs to the thioredoxin family
IXO685_0018145	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO685_0018170	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO685_0018200	COG2968	Membrane
IXO685_0018215	COG3164	Protein of unknown function
IXO685_0018225	COG0312	modulator of DNA gyrase
IXO685_0018230	COG3028	Belongs to the UPF0307 family
IXO685_0018235	COG0312	modulator of DNA gyrase
IXO685_0018260	COG0142	geranyltranstransferase activity
IXO685_0018265	COG1722	exodeoxyribonuclease VII activity
IXO685_0018270	COG0037	tRNA processing
IXO685_0018275	COG1785	Belongs to the alkaline phosphatase family
IXO685_0018280	COG1301	dicarboxylic acid transport
IXO685_0018290	COG3039	Transposase
IXO685_0018305	COG0791	NLP P60 protein
IXO685_0018310	COG0791	NLP P60 protein
IXO685_0018315	COG1047	Peptidyl-prolyl cis-trans
IXO685_0018320	COG2311	Membrane
IXO685_0018325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO685_0018365	COG0489	protein tyrosine kinase activity
IXO685_0018370	COG0717	Belongs to the dCTP deaminase family
IXO685_0018390	COG0412	Dienelactone hydrolase
IXO685_0018400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO685_0018430	COG3179	chitinase
IXO685_0018590	COG0732	type I restriction modification DNA specificity domain
IXO685_0018605	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO685_0018625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO685_0018630	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO685_0018635	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO685_0018650	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO685_0018685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO685_0018690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO685_0018725	COG0587	DNA-directed DNA polymerase activity
IXO685_0018740	COG1297	OPT oligopeptide transporter protein
IXO685_0018760	COG0823	Involved in the tonB-independent uptake of proteins
IXO685_0018760	COG1506	peptidase
IXO685_0018780	COG1917	Cupin 2, conserved barrel domain protein
IXO685_0018780	COG2207	Transcriptional regulator
IXO685_0018805	COG0753	catalase activity
IXO685_0018835	COG0126	phosphoglycerate kinase activity
IXO685_0018845	COG0469	pyruvate kinase activity
IXO685_0018850	COG3588	fructose-bisphosphate aldolase
IXO685_0018855	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO685_0018905	COG2205	protein histidine kinase activity
IXO685_0018905	COG0784	Response regulator, receiver
IXO685_0018905	COG2198	Histidine kinase
IXO685_0018925	COG0175	sulfate reduction
IXO685_0018930	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO685_0018935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO685_0018940	COG0175	sulfate reduction
IXO685_0018945	COG0529	Catalyzes the synthesis of activated sulfate
IXO685_0018945	COG2895	sulfate adenylyltransferase (ATP) activity
IXO685_0018955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO685_0018960	COG0308	aminopeptidase N
IXO685_0018985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO685_0019020	COG1970	mechanosensitive ion channel activity
IXO685_0019050	COG3273	potassium ion transport
IXO685_0019050	COG0471	metal ion transport
IXO685_0019060	COG2022	thiamine diphosphate biosynthetic process
IXO685_0019240	COG0632	four-way junction helicase activity
IXO685_0019250	COG2255	four-way junction helicase activity
IXO685_0019255	COG0824	Thioesterase
IXO685_0019265	COG0848	biopolymer transport protein
IXO685_0019275	COG0823	Involved in the tonB-independent uptake of proteins
IXO685_0019280	COG2885	chlorophyll binding
IXO685_0019290	COG0602	queuosine metabolic process
IXO685_0019315	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO685_0019335	COG0514	ATP-dependent DNA helicase (RecQ)
IXO685_0019340	COG0783	Belongs to the Dps family
IXO685_0019345	COG1643	Atp-dependent helicase
IXO685_0019380	COG0535	radical SAM domain protein
IXO685_0019385	COG0535	radical SAM domain protein
IXO685_0019390	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IXO685_0019405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO685_0019415	COG1215	transferase activity, transferring glycosyl groups
IXO685_0019420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO685_0019430	COG1199	ATP-dependent helicase activity
IXO685_0019440	COG1397	ADP-ribosylglycohydrolase
IXO685_0019450	COG0189	ligase activity
IXO685_0019465	COG0835	chemotaxis
IXO685_0019470	COG0840	transmembrane signaling receptor activity
IXO685_0019475	COG0643	Histidine kinase
IXO685_0019475	COG0784	Response regulator, receiver
IXO685_0019475	COG2198	Histidine kinase
IXO685_0019515	COG1446	asparaginase
IXO685_0019560	COG3537	Alpha-1,2-mannosidase
IXO685_0019630	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO685_0019640	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO685_0019650	COG1388	LysM domain
IXO685_0019650	COG3858	chitin binding
IXO685_0019665	COG0837	glucose binding
IXO685_0019670	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO685_0019680	COG0494	nUDIX hydrolase
IXO685_0019690	COG3956	TIGRFAM MazG family protein
IXO685_0019705	COG0330	HflC and HflK could
IXO685_0019720	COG0509	glycine decarboxylation via glycine cleavage system
IXO685_0019755	COG1960	acyl-CoA dehydrogenase activity
IXO685_0019765	COG1309	transcriptional regulator
IXO685_0019770	COG4771	TonB-dependent receptor
IXO685_0019780	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO685_0019790	COG0463	Glycosyl transferase, family 2
IXO685_0019810	COG1272	protein, Hemolysin III
IXO685_0019815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IXO685_0019820	COG0739	heme binding
IXO685_0019825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO685_0019830	COG0626	cystathionine gamma-synthase activity
IXO685_0019840	COG1760	l-serine dehydratase
IXO685_0019855	COG2353	YceI-like domain
IXO685_0019865	COG2353	YceI-like domain
IXO685_0019935	COG1960	acyl-CoA dehydrogenase activity
IXO685_0019940	COG1024	Enoyl-CoA hydratase
IXO685_0019960	COG1024	Enoyl-CoA hydratase
IXO685_0019960	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO685_0019975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO685_0020005	COG1381	Involved in DNA repair and RecF pathway recombination
IXO685_0020020	COG2954	triphosphatase activity
IXO685_0020045	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO685_0020050	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IXO685_0020055	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO685_0020065	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO685_0020070	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO685_0020075	COG1278	Cold shock
IXO685_0020095	COG1201	RNA secondary structure unwinding
IXO685_0020100	COG1793	dna ligase
IXO685_0020110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO685_0020110	COG1793	dna ligase
IXO685_0020140	COG0183	Belongs to the thiolase family
IXO685_0020160	COG1451	nucleotide metabolic process
IXO685_0020175	COG3039	Transposase
IXO685_0020180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO685_0020185	COG3039	Transposase
IXO685_0020235	COG1047	Peptidyl-prolyl cis-trans
IXO685_0020250	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO685_0020260	COG1902	pentaerythritol trinitrate reductase activity
IXO685_0020265	COG2814	Major facilitator Superfamily
IXO685_0020300	COG0392	lysyltransferase activity
IXO685_0020300	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO685_0020310	COG0251	oxidation-reduction process
IXO685_0020315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO685_0020330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO685_0020355	COG1595	DNA-templated transcription, initiation
IXO685_0020370	COG2878	Part of a membrane complex involved in electron transport
IXO685_0020380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO685_0020380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO685_0020400	COG0833	amino acid
IXO685_0020405	COG2040	homocysteine
IXO685_0020420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO685_0020455	COG0529	Catalyzes the synthesis of activated sulfate
IXO685_0020455	COG2895	sulfate adenylyltransferase (ATP) activity
IXO685_0020500	COG1981	membrane
IXO685_0020525	COG1131	(ABC) transporter
IXO685_0020530	COG4771	TonB-dependent receptor
IXO685_0020540	COG0825	malonyl-CoA metabolic process
IXO685_0020560	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO685_0020565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO685_0020585	COG0750	zinc metalloprotease
IXO685_0020595	COG0575	Belongs to the CDS family
IXO685_0020605	COG0233	cytoplasmic translational termination
IXO685_0020620	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO685_0020680	COG1393	Belongs to the ArsC family
IXO685_0020695	COG0367	asparagine synthase
IXO685_0020705	COG4774	siderophore transport
IXO685_0020730	COG2207	Transcriptional regulator
IXO685_0020745	COG1566	PFAM secretion protein HlyD family protein
IXO685_0020750	COG2814	Major facilitator Superfamily
IXO685_0020795	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO685_0020805	COG1960	acyl-CoA dehydrogenase activity
IXO685_0020820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO685_0020830	COG2914	Belongs to the UPF0125 (RnfH) family
IXO685_0020835	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO685_0020845	COG0497	DNA recombination
IXO685_0020855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO685_0020865	COG0484	heat shock protein binding
IXO685_0020870	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO685_0020875	COG0287	Prephenate dehydrogenase
IXO685_0020875	COG1605	Chorismate mutase
IXO685_0020890	COG0583	DNA-binding transcription factor activity
IXO685_0020905	COG1132	(ABC) transporter
IXO685_0020940	COG2850	peptidyl-arginine hydroxylation
IXO685_0021015	COG1131	(ABC) transporter
IXO685_0021020	COG1725	Transcriptional regulator
IXO685_0021030	COG0386	Belongs to the glutathione peroxidase family
IXO685_0021045	COG2900	Belongs to the SlyX family
IXO685_0021060	COG1609	Transcriptional regulator
IXO685_0021070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO685_0021080	COG0646	methionine synthase
IXO685_0021080	COG1410	methionine synthase
IXO685_0021085	COG0646	methionine synthase
IXO685_0021085	COG1410	methionine synthase
IXO685_0021090	COG2226	methyltransferase
IXO685_0021095	COG1960	acyl-CoA dehydrogenase activity
IXO685_0021120	COG0557	exoribonuclease II activity
IXO685_0021135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO685_0021145	COG3039	Transposase
IXO685_0021190	COG1278	Cold shock
IXO685_0021270	COG3039	Transposase
IXO685_0021280	COG0583	DNA-binding transcription factor activity
IXO685_0021350	COG0742	ribosomal rna small subunit methyltransferase
IXO685_0021355	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO685_0021365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO685_0021370	COG0405	Gamma-glutamyltransferase
IXO685_0021520	COG3039	Transposase
IXO685_0021530	COG3039	Transposase
IXO685_0021545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO685_0021545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO685_0021550	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO685_0021555	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO685_0021555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO685_0021560	COG1609	Transcriptional regulator
IXO685_0021580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO685_0021585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO685_0021595	COG2902	Dehydrogenase
IXO685_0021600	COG3039	Transposase
IXO685_0021610	COG2205	protein histidine kinase activity
IXO685_0021610	COG0784	Response regulator, receiver
IXO685_0021610	COG5002	protein histidine kinase activity
IXO685_0021615	COG2733	membrane
IXO685_0021625	COG1121	(ABC) transporter
IXO685_0021630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO685_0021635	COG2223	nitrite transmembrane transporter activity
IXO685_0021645	COG0243	molybdopterin cofactor binding
IXO685_0021655	COG0477	Major facilitator Superfamily
IXO685_0021665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO685_0021670	COG0174	glutamine synthetase
IXO685_0021705	COG3842	ATPase activity
IXO685_0021715	COG1177	transmembrane transport
IXO685_0021725	COG1012	belongs to the aldehyde dehydrogenase family
IXO685_0021740	COG4535	Mg2 and Co2 transporter CorC
IXO685_0021760	COG1702	phosphate starvation-inducible protein PhoH
IXO685_0021785	COG0741	lytic transglycosylase activity
IXO685_0021790	COG0723	plastoquinol--plastocyanin reductase activity
IXO685_0021795	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO685_0021800	COG2857	Cytochrome c1
IXO685_0021805	COG0625	glutathione transferase activity
IXO685_0021810	COG2969	positive regulation of protein catabolic process
IXO685_0021845	COG3328	transposase activity
IXO685_0021925	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO685_0021940	COG1570	exodeoxyribonuclease VII activity
IXO685_0021945	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO685_0021950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO685_0021950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO685_0021955	COG0802	atpase or kinase
IXO685_0021960	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO685_0021965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO685_0021985	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_0021995	COG0501	Belongs to the peptidase M48B family
IXO685_0022005	COG2081	HI0933 family
IXO685_0022010	COG4681	YaeQ
IXO685_0022015	COG1671	Belongs to the UPF0178 family
IXO685_0022020	COG1278	Cold shock
IXO685_0022025	COG0625	glutathione transferase activity
IXO685_0022040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO685_0022045	COG0513	Belongs to the DEAD box helicase family
IXO685_0022050	COG0488	(ABC) transporter
IXO685_0022070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO685_0022075	COG0483	inositol monophosphate 1-phosphatase activity
IXO685_0022090	COG5001	Diguanylate cyclase
IXO685_0022090	COG3300	MHYT domain
IXO685_0022095	COG1509	lysine 2,3-aminomutase activity
IXO685_0022110	COG0402	S-adenosylhomocysteine deaminase activity
IXO685_0022115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO685_0022140	COG4677	pectinesterase activity
IXO685_0022160	COG3039	Transposase
IXO685_0022190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO685_0022215	COG2166	iron-sulfur cluster assembly
IXO685_0022230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO685_0022235	COG0137	argininosuccinate synthase activity
IXO685_0022245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO685_0022250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO685_0022265	COG0165	Argininosuccinate lyase
IXO685_0022285	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO685_0022330	COG4988	ABC transporter
IXO685_0022335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO685_0022445	COG3209	COG3209 Rhs family protein
IXO685_0022455	COG3039	Transposase
IXO685_0022480	COG2198	Histidine kinase
IXO685_0022480	COG0784	Response regulator, receiver
IXO685_0022480	COG0643	Histidine kinase
IXO685_0022535	COG1684	flagellar biosynthetic protein fliR
IXO685_0022550	COG3190	flagellar
IXO685_0022600	COG1677	Flagellar hook-basal body complex protein FliE
IXO685_0022630	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_0022640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO685_0022660	COG2201	protein-glutamate methylesterase activity
IXO685_0022690	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO685_0022695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO685_0022730	COG4787	bacterial-type flagellum-dependent cell motility
IXO685_0022740	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO685_0022745	COG1558	bacterial-type flagellum-dependent cell motility
IXO685_0022755	COG0784	Response regulator, receiver
IXO685_0022755	COG0835	chemotaxis
IXO685_0022775	COG5002	protein histidine kinase activity
IXO685_0022785	COG4585	Histidine kinase
IXO685_0022790	COG5001	Diguanylate cyclase
IXO685_0022815	COG0482	sulfurtransferase activity
IXO685_0022830	COG0542	response to heat
IXO685_0022855	COG0492	ferredoxin-NADP+ reductase activity
IXO685_0022860	COG1674	ftsk spoiiie
IXO685_0022880	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO685_0022900	COG0038	chloride channel
IXO685_0022910	COG0183	Belongs to the thiolase family
IXO685_0022915	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO685_0022915	COG1024	Enoyl-CoA hydratase
IXO685_0022930	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO685_0022950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO685_0022960	COG0303	'Molybdopterin
IXO685_0023035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO685_0023045	COG3039	Transposase
IXO685_0023075	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO685_0023085	COG0531	amino acid
IXO685_0023090	COG0531	amino acid
IXO685_0023100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO685_0023105	COG0277	FAD linked oxidase domain protein
IXO685_0023165	COG4133	protoheme IX ABC transporter activity
IXO685_0023170	COG0436	Aminotransferase
IXO685_0023195	COG1187	pseudouridine synthase activity
IXO685_0023200	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO685_0023205	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO685_0023210	COG2350	Protein conserved in bacteria
IXO685_0023240	COG1175	transmembrane transport
IXO685_0023245	COG0395	ABC-type sugar transport system, permease component
IXO685_0023270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO685_0023280	COG2957	Belongs to the agmatine deiminase family
IXO685_0023295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO685_0023300	COG0539	negative regulation of cytoplasmic translation
IXO685_0023305	COG0776	regulation of translation
IXO685_0023315	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO685_0023320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO685_0023330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO685_0023360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO685_0023375	COG3002	Belongs to the UPF0753 family
IXO685_0023380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO685_0023385	COG0583	DNA-binding transcription factor activity
IXO685_0023400	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_0023415	COG0583	DNA-binding transcription factor activity
IXO685_0023420	COG0583	DNA-binding transcription factor activity
IXO685_0023435	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO685_0023455	COG0668	transmembrane transport
IXO685_0023480	COG1028	Short-chain dehydrogenase reductase Sdr
IXO685_0023485	COG1183	phosphatidylcholine synthase activity
IXO685_0023495	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO685_0023510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO685_0023510	COG0723	plastoquinol--plastocyanin reductase activity
IXO685_0023520	COG2183	response to ionizing radiation
IXO685_0023535	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO685_0023550	COG0671	phosphoesterase, PA-phosphatase related
IXO685_0023570	COG1794	racemase activity, acting on amino acids and derivatives
IXO685_0023575	COG0697	spore germination
IXO685_0023600	COG1012	belongs to the aldehyde dehydrogenase family
IXO685_0023645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO685_0023660	COG0124	histidyl-tRNA synthetase
IXO685_0023690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO685_0023705	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO685_0023705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO685_0023715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO685_0023725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO685_0023725	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO685_0023815	COG0653	protein targeting