locus-tag	class	description
IXO74_000005	COG2201	protein-glutamate methylesterase activity
IXO74_000035	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO74_000040	COG0235	Class ii aldolase
IXO74_000045	COG0531	amino acid
IXO74_000050	COG0531	amino acid
IXO74_000060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO74_000065	COG0277	FAD linked oxidase domain protein
IXO74_000130	COG0436	Aminotransferase
IXO74_000155	COG1187	pseudouridine synthase activity
IXO74_000160	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO74_000165	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO74_000170	COG2350	Protein conserved in bacteria
IXO74_000200	COG1175	transmembrane transport
IXO74_000205	COG0395	ABC-type sugar transport system, permease component
IXO74_000230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO74_000240	COG2957	Belongs to the agmatine deiminase family
IXO74_000255	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO74_000260	COG0539	negative regulation of cytoplasmic translation
IXO74_000265	COG0776	regulation of translation
IXO74_000280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO74_000290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO74_000310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO74_000325	COG3002	Belongs to the UPF0753 family
IXO74_000330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO74_000335	COG0583	DNA-binding transcription factor activity
IXO74_000365	COG0583	DNA-binding transcription factor activity
IXO74_000370	COG0583	DNA-binding transcription factor activity
IXO74_000390	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO74_000410	COG0668	transmembrane transport
IXO74_000435	COG1028	Short-chain dehydrogenase reductase Sdr
IXO74_000440	COG1183	phosphatidylcholine synthase activity
IXO74_000450	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO74_000465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO74_000465	COG0723	plastoquinol--plastocyanin reductase activity
IXO74_000475	COG2183	response to ionizing radiation
IXO74_000490	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO74_000505	COG0671	phosphoesterase, PA-phosphatase related
IXO74_000530	COG1794	racemase activity, acting on amino acids and derivatives
IXO74_000535	COG0697	spore germination
IXO74_000540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IXO74_000545	COG0167	dihydroorotate dehydrogenase activity
IXO74_000560	COG1012	belongs to the aldehyde dehydrogenase family
IXO74_000600	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO74_000620	COG0124	histidyl-tRNA synthetase
IXO74_000640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO74_000655	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO74_000655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO74_000665	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO74_000675	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO74_000675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO74_000910	COG0653	protein targeting
IXO74_000960	COG2201	protein-glutamate methylesterase activity
IXO74_000970	COG2801	Transposase and inactivated derivatives
IXO74_000985	COG3039	Transposase
IXO74_001040	COG0322	excinuclease ABC activity
IXO74_001050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO74_001060	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO74_001075	COG0811	peptide transport
IXO74_001100	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO74_001115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO74_001130	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO74_001145	COG0354	folic acid binding
IXO74_001160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO74_001170	COG0363	glucosamine-6-phosphate deaminase activity
IXO74_001175	COG0129	dihydroxy-acid dehydratase activity
IXO74_001180	COG0800	Aldolase
IXO74_001220	COG0784	Response regulator, receiver
IXO74_001220	COG5002	protein histidine kinase activity
IXO74_001220	COG2205	protein histidine kinase activity
IXO74_001315	COG0386	Belongs to the glutathione peroxidase family
IXO74_001340	COG1595	DNA-templated transcription, initiation
IXO74_001400	COG3706	GGDEF domain
IXO74_001400	COG4251	negative regulation of phosphorylation
IXO74_001400	COG2203	Gaf domain
IXO74_001400	COG5001	Diguanylate cyclase
IXO74_001420	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO74_001450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO74_001455	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO74_001465	COG0617	tRNA 3'-terminal CCA addition
IXO74_001475	COG1469	GTP cyclohydrolase I activity
IXO74_001480	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO74_001525	COG4566	intracellular signal transduction
IXO74_001555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO74_001560	COG1605	Chorismate mutase
IXO74_001560	COG0077	Prephenate dehydratase
IXO74_001570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO74_001610	COG1228	amidohydrolase
IXO74_001615	COG2986	histidine ammonia-lyase
IXO74_001625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO74_001650	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO74_001670	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO74_001685	COG3115	cell septum assembly
IXO74_001695	COG0359	binds to the 23S rRNA
IXO74_001705	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO74_001710	COG0316	Belongs to the HesB IscA family
IXO74_001740	COG0288	reversible hydration of carbon dioxide
IXO74_001770	COG2925	Exonuclease
IXO74_001780	COG0667	Aldo Keto reductase
IXO74_001805	COG0116	Belongs to the methyltransferase superfamily
IXO74_001805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO74_001850	COG0494	nUDIX hydrolase
IXO74_001860	COG1024	Enoyl-CoA hydratase
IXO74_001870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO74_001915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO74_001920	COG0573	inorganic phosphate transmembrane transporter activity
IXO74_001935	COG0704	Plays a role in the regulation of phosphate uptake
IXO74_001945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO74_001985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO74_001990	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO74_001995	COG1862	Preprotein translocase
IXO74_002000	COG0343	queuine tRNA-ribosyltransferase activity
IXO74_002100	COG0405	Gamma-glutamyltransferase
IXO74_002105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO74_002120	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO74_002125	COG0742	ribosomal rna small subunit methyltransferase
IXO74_002175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO74_002230	COG0303	'Molybdopterin
IXO74_002240	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO74_002250	COG1426	Protein conserved in bacteria
IXO74_002260	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO74_002275	COG1024	Enoyl-CoA hydratase
IXO74_002275	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO74_002280	COG0183	Belongs to the thiolase family
IXO74_002285	COG0038	chloride channel
IXO74_002305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO74_002325	COG1674	ftsk spoiiie
IXO74_002330	COG0492	ferredoxin-NADP+ reductase activity
IXO74_002355	COG0542	response to heat
IXO74_002375	COG0482	sulfurtransferase activity
IXO74_002400	COG5001	Diguanylate cyclase
IXO74_002405	COG4585	Histidine kinase
IXO74_002415	COG5002	protein histidine kinase activity
IXO74_002435	COG0784	Response regulator, receiver
IXO74_002435	COG0835	chemotaxis
IXO74_002445	COG1558	bacterial-type flagellum-dependent cell motility
IXO74_002450	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO74_002460	COG4787	bacterial-type flagellum-dependent cell motility
IXO74_002500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO74_002505	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO74_002535	COG2201	protein-glutamate methylesterase activity
IXO74_002555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO74_002565	COG1028	Short-chain dehydrogenase reductase Sdr
IXO74_002600	COG1677	Flagellar hook-basal body complex protein FliE
IXO74_002650	COG3190	flagellar
IXO74_002665	COG1684	flagellar biosynthetic protein fliR
IXO74_002720	COG0643	Histidine kinase
IXO74_002720	COG0784	Response regulator, receiver
IXO74_002720	COG2198	Histidine kinase
IXO74_002765	COG3209	COG3209 Rhs family protein
IXO74_002880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO74_002885	COG4988	ABC transporter
IXO74_002935	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO74_002955	COG0165	Argininosuccinate lyase
IXO74_002970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO74_002975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO74_002985	COG0137	argininosuccinate synthase activity
IXO74_002990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO74_003005	COG2166	iron-sulfur cluster assembly
IXO74_003030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO74_003055	COG4677	pectinesterase activity
IXO74_003080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO74_003085	COG0402	S-adenosylhomocysteine deaminase activity
IXO74_003100	COG1509	lysine 2,3-aminomutase activity
IXO74_003105	COG5001	Diguanylate cyclase
IXO74_003105	COG3300	MHYT domain
IXO74_003120	COG0483	inositol monophosphate 1-phosphatase activity
IXO74_003125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO74_003145	COG0488	(ABC) transporter
IXO74_003150	COG0513	Belongs to the DEAD box helicase family
IXO74_003155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO74_003160	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IXO74_003170	COG0625	glutathione transferase activity
IXO74_003180	COG1671	Belongs to the UPF0178 family
IXO74_003185	COG4681	YaeQ
IXO74_003190	COG2081	HI0933 family
IXO74_003200	COG0501	Belongs to the peptidase M48B family
IXO74_003210	COG1028	Short-chain dehydrogenase reductase Sdr
IXO74_003230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO74_003235	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO74_003240	COG0802	atpase or kinase
IXO74_003245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO74_003245	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO74_003250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO74_003270	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO74_003385	COG2969	positive regulation of protein catabolic process
IXO74_003390	COG0625	glutathione transferase activity
IXO74_003395	COG2857	Cytochrome c1
IXO74_003400	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO74_003405	COG0723	plastoquinol--plastocyanin reductase activity
IXO74_003410	COG0741	lytic transglycosylase activity
IXO74_003435	COG1702	phosphate starvation-inducible protein PhoH
IXO74_003455	COG4535	Mg2 and Co2 transporter CorC
IXO74_003470	COG1012	belongs to the aldehyde dehydrogenase family
IXO74_003500	COG3842	ATPase activity
IXO74_003535	COG0174	glutamine synthetase
IXO74_003540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO74_003550	COG0477	Major facilitator Superfamily
IXO74_003560	COG0243	molybdopterin cofactor binding
IXO74_003570	COG2223	nitrite transmembrane transporter activity
IXO74_003580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO74_003585	COG1121	(ABC) transporter
IXO74_003595	COG2733	membrane
IXO74_003600	COG5002	protein histidine kinase activity
IXO74_003600	COG2205	protein histidine kinase activity
IXO74_003600	COG0784	Response regulator, receiver
IXO74_003610	COG3039	Transposase
IXO74_003615	COG2902	Dehydrogenase
IXO74_003625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO74_003630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO74_003655	COG1609	Transcriptional regulator
IXO74_003660	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO74_003660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO74_003665	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO74_003670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO74_003670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO74_003900	COG4771	TonB-dependent receptor
IXO74_003910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO74_003930	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO74_003935	COG1360	Flagellar Motor Protein
IXO74_003945	COG0835	chemotaxis
IXO74_003955	COG0745	RESPONSE REGULATOR receiver
IXO74_003985	COG0840	transmembrane signaling receptor activity
IXO74_003995	COG0840	transmembrane signaling receptor activity
IXO74_004005	COG0840	transmembrane signaling receptor activity
IXO74_004010	COG0840	transmembrane signaling receptor activity
IXO74_004015	COG0840	transmembrane signaling receptor activity
IXO74_004020	COG0840	transmembrane signaling receptor activity
IXO74_004035	COG0835	chemotaxis
IXO74_004070	COG0840	transmembrane signaling receptor activity
IXO74_004100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO74_004130	COG0318	PFAM AMP-dependent synthetase and ligase
IXO74_004135	COG1024	Enoyl-CoA hydratase
IXO74_004140	COG2198	Histidine kinase
IXO74_004140	COG0784	Response regulator, receiver
IXO74_004140	COG2205	protein histidine kinase activity
IXO74_004210	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO74_004220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO74_004225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO74_004235	COG0505	Belongs to the CarA family
IXO74_004240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO74_004250	COG2258	MOSC domain
IXO74_004255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO74_004305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO74_004325	COG0477	Major facilitator Superfamily
IXO74_004335	COG1070	Carbohydrate kinase
IXO74_004345	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO74_004360	COG0800	Aldolase
IXO74_004365	COG4948	Mandelate Racemase Muconate Lactonizing
IXO74_004375	COG3734	2-keto-3-deoxy-galactonokinase
IXO74_004380	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO74_004390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO74_004410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO74_004415	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO74_004425	COG0351	phosphomethylpyrimidine kinase
IXO74_004455	COG0583	DNA-binding transcription factor activity
IXO74_004460	COG1741	Belongs to the pirin family
IXO74_004485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO74_004490	COG0305	Participates in initiation and elongation during chromosome replication
IXO74_004515	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO74_004520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO74_004525	COG2137	regulation of response to DNA damage stimulus
IXO74_004530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO74_004545	COG1546	Belongs to the CinA family
IXO74_004550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO74_004560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO74_004565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO74_004575	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO74_004580	COG1534	Rna-binding protein
IXO74_004595	COG1238	metal cluster binding
IXO74_004600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO74_004605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO74_004610	COG2840	Smr protein MutS2
IXO74_004620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO74_004630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO74_004635	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO74_004640	COG0148	phosphopyruvate hydratase activity
IXO74_004650	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO74_004655	COG0504	CTP synthase activity
IXO74_004685	COG0306	phosphate transporter
IXO74_004695	COG1253	flavin adenine dinucleotide binding
IXO74_004710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO74_004720	COG0477	Major facilitator Superfamily
IXO74_004730	COG1132	(ABC) transporter
IXO74_004735	COG1136	(ABC) transporter
IXO74_004750	COG0438	transferase activity, transferring glycosyl groups
IXO74_004760	COG2264	protein methyltransferase activity
IXO74_004790	COG2244	polysaccharide biosynthetic process
IXO74_004840	COG1595	DNA-templated transcription, initiation
IXO74_004855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO74_004875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO74_004940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO74_004945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO74_005000	COG1858	cytochrome C peroxidase
IXO74_005035	COG0631	protein serine/threonine phosphatase activity
IXO74_005210	COG0316	Belongs to the HesB IscA family
IXO74_005210	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IXO74_005215	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO74_005225	COG0428	transporter
IXO74_005230	COG0428	transporter
IXO74_005235	COG3064	Membrane
IXO74_005245	COG1530	ribonuclease E activity
IXO74_005260	COG1054	Belongs to the UPF0176 family
IXO74_005280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO74_005325	COG3039	Transposase
IXO74_005365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO74_005365	COG1648	precorrin-2 dehydrogenase activity
IXO74_005475	COG4206	TonB-dependent receptor
IXO74_005525	COG0531	amino acid
IXO74_005540	COG0006	proline dipeptidase activity
IXO74_005550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO74_005565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO74_005570	COG3938	Belongs to the proline racemase family
IXO74_005580	COG0552	protein localization to endoplasmic reticulum
IXO74_005600	COG0784	Response regulator, receiver
IXO74_005600	COG4191	Histidine kinase
IXO74_005685	COG3040	lipid binding
IXO74_005730	COG0438	transferase activity, transferring glycosyl groups
IXO74_005740	COG0438	transferase activity, transferring glycosyl groups
IXO74_005745	COG0438	transferase activity, transferring glycosyl groups
IXO74_005800	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO74_005815	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO74_005855	COG0556	nucleotide-excision repair
IXO74_005860	COG4969	Belongs to the N-Me-Phe pilin family
IXO74_005910	COG1611	Belongs to the LOG family
IXO74_005925	COG2095	MarC family integral membrane protein
IXO74_005935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO74_005970	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO74_005975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO74_005990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IXO74_005995	COG0195	Participates in both transcription termination and antitermination
IXO74_006000	COG0779	Required for maturation of 30S ribosomal subunits
IXO74_006010	COG1007	ATP synthesis coupled electron transport
IXO74_006040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO74_006045	COG1034	ATP synthesis coupled electron transport
IXO74_006050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO74_006055	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO74_006060	COG0649	NAD binding
IXO74_006065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO74_006075	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO74_006090	COG0149	triose-phosphate isomerase activity
IXO74_006145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO74_006150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO74_006155	COG0159	tryptophan synthase activity
IXO74_006175	COG0135	phosphoribosylanthranilate isomerase activity
IXO74_006180	COG0101	tRNA pseudouridine synthase activity
IXO74_006200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO74_006205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO74_006210	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO74_006215	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO74_006260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO74_006270	COG0412	Dienelactone hydrolase
IXO74_006290	COG0717	Belongs to the dCTP deaminase family
IXO74_006295	COG0489	protein tyrosine kinase activity
IXO74_006335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO74_006340	COG2311	Membrane
IXO74_006345	COG1047	Peptidyl-prolyl cis-trans
IXO74_006350	COG0791	NLP P60 protein
IXO74_006355	COG0791	NLP P60 protein
IXO74_006370	COG1301	dicarboxylic acid transport
IXO74_006380	COG0037	tRNA processing
IXO74_006385	COG1722	exodeoxyribonuclease VII activity
IXO74_006390	COG0142	geranyltranstransferase activity
IXO74_006420	COG0312	modulator of DNA gyrase
IXO74_006425	COG3028	Belongs to the UPF0307 family
IXO74_006430	COG0312	modulator of DNA gyrase
IXO74_006440	COG3164	Protein of unknown function
IXO74_006455	COG2968	Membrane
IXO74_006485	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO74_006510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO74_006535	COG3118	belongs to the thioredoxin family
IXO74_006655	COG2022	thiamine diphosphate biosynthetic process
IXO74_006665	COG3273	potassium ion transport
IXO74_006665	COG0471	metal ion transport
IXO74_006695	COG1970	mechanosensitive ion channel activity
IXO74_006715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO74_006740	COG0308	aminopeptidase N
IXO74_006745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO74_006765	COG0529	Catalyzes the synthesis of activated sulfate
IXO74_006765	COG2895	sulfate adenylyltransferase (ATP) activity
IXO74_006770	COG0175	sulfate reduction
IXO74_006775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO74_006780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO74_006785	COG0175	sulfate reduction
IXO74_006805	COG2205	protein histidine kinase activity
IXO74_006805	COG2198	Histidine kinase
IXO74_006805	COG0784	Response regulator, receiver
IXO74_006855	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO74_006860	COG3588	fructose-bisphosphate aldolase
IXO74_006865	COG0469	pyruvate kinase activity
IXO74_006905	COG0753	catalase activity
IXO74_006930	COG1917	Cupin 2, conserved barrel domain protein
IXO74_006930	COG2207	Transcriptional regulator
IXO74_006950	COG0823	Involved in the tonB-independent uptake of proteins
IXO74_006950	COG1506	peptidase
IXO74_006970	COG1297	OPT oligopeptide transporter protein
IXO74_006985	COG0587	DNA-directed DNA polymerase activity
IXO74_007055	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO74_007070	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO74_007075	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO74_007080	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO74_007100	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO74_007175	COG3039	Transposase
IXO74_007290	COG3179	chitinase
IXO74_007355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO74_007365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO74_007375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO74_007485	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IXO74_007510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO74_007525	COG2197	response regulator
IXO74_007530	COG4585	Histidine kinase
IXO74_007545	COG2894	cell division
IXO74_007550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO74_007560	COG0642	Histidine kinase
IXO74_007565	COG0745	RESPONSE REGULATOR receiver
IXO74_007570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO74_007580	COG2194	sulfuric ester hydrolase activity
IXO74_007610	COG3551	Protein conserved in bacteria
IXO74_007670	COG0203	ribosomal protein L17
IXO74_007680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO74_007685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO74_007695	COG0201	protein transport
IXO74_007705	COG1841	ribosomal large subunit assembly
IXO74_007735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO74_007745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO74_007750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO74_007755	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO74_007760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO74_007770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO74_007785	COG0089	rRNA binding
IXO74_007790	COG0088	Forms part of the polypeptide exit tunnel
IXO74_007795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO74_007800	COG0051	transcription antitermination factor activity, RNA binding
IXO74_007820	COG0049	tRNA binding
IXO74_007825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO74_007830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO74_007835	COG0085	RNA polymerase activity
IXO74_007840	COG0222	ribosome binding
IXO74_007845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO74_007855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO74_007860	COG0250	Participates in transcription elongation, termination and antitermination
IXO74_007865	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO74_007895	COG0012	GTP binding
IXO74_007900	COG0193	aminoacyl-tRNA hydrolase activity
IXO74_007910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO74_007925	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO74_007940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO74_007950	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO74_007970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO74_007975	COG1295	ribonuclease BN
IXO74_008005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO74_008015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO74_008040	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO74_008065	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO74_008080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO74_008080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO74_008120	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO74_008130	COG3634	alkyl hydroperoxide reductase activity
IXO74_008135	COG0583	DNA-binding transcription factor activity
IXO74_008140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO74_008170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO74_008205	COG0584	glycerophosphoryl diester phosphodiesterase
IXO74_008255	COG0625	glutathione transferase activity
IXO74_008260	COG0039	L-malate dehydrogenase activity
IXO74_008265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO74_008270	COG1217	gtp-binding protein TYPA
IXO74_008290	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO74_008425	COG3781	membrane
IXO74_008435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO74_008470	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO74_008490	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO74_008515	COG3710	Transcriptional regulator
IXO74_008520	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO74_008530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO74_008560	COG2226	methyltransferase
IXO74_008565	COG0066	3-isopropylmalate dehydratase activity
IXO74_008570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO74_008600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO74_008605	COG1538	Outer membrane efflux protein
IXO74_008610	COG1519	Transferase
IXO74_008615	COG1560	Kdo2-lipid A biosynthetic process
IXO74_008675	COG0308	aminopeptidase N
IXO74_008680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO74_008690	COG0330	HflC and HflK could
IXO74_008695	COG0330	HflC and HflK could
IXO74_008715	COG0678	peroxiredoxin activity
IXO74_008725	COG2826	transposase and inactivated derivatives, IS30 family
IXO74_008805	COG3829	transcription factor binding
IXO74_008845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO74_008850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO74_008860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO74_008865	COG1028	Short-chain dehydrogenase reductase Sdr
IXO74_008890	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO74_008910	COG3039	Transposase
IXO74_008945	COG1518	maintenance of DNA repeat elements
IXO74_008950	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO74_008995	COG2188	Transcriptional regulator
IXO74_009010	COG1450	Type ii and iii secretion system protein
IXO74_009025	COG3166	PFAM Fimbrial assembly family protein
IXO74_009030	COG3156	type II secretion system protein K
IXO74_009035	COG4795	General secretion pathway protein
IXO74_009040	COG2165	general secretion pathway protein
IXO74_009045	COG4970	Tfp pilus assembly protein FimT
IXO74_009050	COG2165	general secretion pathway protein
IXO74_009055	COG1459	type II secretion system
IXO74_009065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO74_009080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXO74_009080	COG0047	phosphoribosylformylglycinamidine synthase activity
IXO74_009085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO74_009090	COG4974	Belongs to the 'phage' integrase family
IXO74_009105	COG0795	lipopolysaccharide-transporting ATPase activity
IXO74_009115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO74_009130	COG0525	valine-tRNA ligase activity
IXO74_009225	COG1183	phosphatidylcholine synthase activity
IXO74_009235	COG0442	prolyl-tRNA aminoacylation
IXO74_009255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO74_009260	COG1127	ABC transporter
IXO74_009265	COG3218	ABC-type transport auxiliary lipoprotein component
IXO74_009265	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO74_009300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO74_009305	COG0662	Cupin 2, conserved barrel domain protein
IXO74_009305	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO74_009330	COG2086	electron transfer activity
IXO74_009395	COG0626	cystathionine gamma-synthase activity
IXO74_009425	COG0625	glutathione transferase activity
IXO74_009440	COG0513	Belongs to the DEAD box helicase family
IXO74_009445	COG0720	synthase
IXO74_009455	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO74_009460	COG1956	GAF domain-containing protein
IXO74_009500	COG0339	signal peptide processing
IXO74_009550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO74_009555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO74_009605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXO74_009610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO74_009615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO74_009620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO74_009630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO74_009640	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO74_009660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO74_009670	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO74_009700	COG2011	ABC-type metal ion transport system permease component
IXO74_009710	COG0697	spore germination
IXO74_009750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO74_009755	COG1187	pseudouridine synthase activity
IXO74_009760	COG2813	Specifically methylates the guanine in position
IXO74_009790	COG2205	protein histidine kinase activity
IXO74_009790	COG2202	Pas domain
IXO74_009815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO74_009865	COG0745	RESPONSE REGULATOR receiver
IXO74_009880	COG1404	Belongs to the peptidase S8 family
IXO74_009895	COG0842	Transport permease protein
IXO74_009900	COG1131	(ABC) transporter
IXO74_009905	COG0025	NhaP-type Na H and K H
IXO74_009915	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO74_009925	COG1573	uracil-dna glycosylase
IXO74_009935	COG3384	dioxygenase
IXO74_009950	COG0667	Aldo Keto reductase
IXO74_009960	COG3590	peptidase
IXO74_009980	COG0531	amino acid
IXO74_009995	COG2972	Histidine kinase
IXO74_010045	COG1271	oxidase subunit
IXO74_010055	COG3039	Transposase
IXO74_010210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO74_010220	COG1560	Kdo2-lipid A biosynthetic process
IXO74_010285	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO74_010290	COG0242	peptide deformylase activity
IXO74_010295	COG1652	LysM domain
IXO74_010300	COG0758	DNA mediated transformation
IXO74_010305	COG2922	Belongs to the Smg family
IXO74_010320	COG1754	DNA topoisomerase type I activity
IXO74_010320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO74_010325	COG0009	L-threonylcarbamoyladenylate synthase
IXO74_010340	COG1028	Short-chain dehydrogenase reductase Sdr
IXO74_010350	COG0616	signal peptide processing
IXO74_010355	COG0534	Mate efflux family protein
IXO74_010380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO74_010415	COG1324	tolerance protein
IXO74_010425	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO74_010430	COG0511	ligase activity, forming carbon-carbon bonds
IXO74_010440	COG0439	Biotin carboxylase
IXO74_010485	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO74_010505	COG2267	carboxylic ester hydrolase activity
IXO74_010515	COG2267	carboxylic ester hydrolase activity
IXO74_010525	COG0138	bifunctional purine biosynthesis protein purh
IXO74_010535	COG0151	Belongs to the GarS family
IXO74_010560	COG1289	transmembrane transporter activity
IXO74_010575	COG2814	Major facilitator Superfamily
IXO74_010590	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO74_010625	COG0745	RESPONSE REGULATOR receiver
IXO74_010670	COG0739	heme binding
IXO74_010685	COG2211	Major facilitator Superfamily
IXO74_010690	COG0708	Exodeoxyribonuclease III
IXO74_010705	COG1192	Involved in chromosome partitioning
IXO74_010710	COG1475	DNA binding
IXO74_010725	COG0463	Glycosyl transferase, family 2
IXO74_010750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO74_010775	COG4221	oxidoreductase activity
IXO74_010800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO74_010805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO74_010825	COG3485	protocatechuate 3,4-dioxygenase
IXO74_010860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO74_010865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO74_010875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO74_010875	COG1042	CoA-binding domain protein
IXO74_010875	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO74_010890	COG2239	Acts as a magnesium transporter
IXO74_010905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO74_010925	COG3100	YcgL domain-containing protein
IXO74_010930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO74_010940	COG0463	Glycosyl transferase, family 2
IXO74_010955	COG1028	Short-chain dehydrogenase reductase Sdr
IXO74_010965	COG0156	8-amino-7-oxononanoate synthase activity
IXO74_010970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO74_010975	COG1040	competence protein
IXO74_010980	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO74_010990	COG0628	permease
IXO74_011000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO74_011015	COG0753	catalase activity
IXO74_011060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO74_011065	COG0180	Tryptophanyl-tRNA synthetase
IXO74_011070	COG3237	CsbD-like
IXO74_011105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO74_011120	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO74_011125	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO74_011125	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO74_011165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO74_011190	COG1566	PFAM secretion protein HlyD family protein
IXO74_011210	COG1199	ATP-dependent helicase activity
IXO74_011250	COG0583	DNA-binding transcription factor activity
IXO74_011295	COG0625	glutathione transferase activity
IXO74_011330	COG4555	ABC transporter
IXO74_011340	COG1476	TRANSCRIPTIONal
IXO74_011370	COG1131	(ABC) transporter
IXO74_011375	COG0842	Transport permease protein
IXO74_011385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO74_011455	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO74_011465	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO74_011475	COG0564	pseudouridine synthase activity
IXO74_011500	COG0339	signal peptide processing
IXO74_011530	COG3254	rhamnose metabolic process
IXO74_011535	COG0738	Major facilitator superfamily
IXO74_011540	COG1414	Transcriptional regulator
IXO74_011555	COG2205	protein histidine kinase activity
IXO74_011565	COG3459	Glycosyltransferase 36 associated
IXO74_011570	COG2211	Major facilitator Superfamily
IXO74_011575	COG3265	gluconokinase activity
IXO74_011590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO74_011665	COG1127	ABC transporter
IXO74_011670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO74_011675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO74_011690	COG2853	Lipoprotein
IXO74_011715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO74_011780	COG0676	glucose-6-phosphate 1-epimerase activity
IXO74_011800	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO74_011810	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO74_011820	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO74_011825	COG1064	alcohol dehydrogenase
IXO74_011870	COG1522	sequence-specific DNA binding
IXO74_011875	COG3186	Phenylalanine-4-hydroxylase
IXO74_011890	COG2755	lipolytic protein G-D-S-L family
IXO74_011955	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO74_011960	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO74_011965	COG3132	Protein of unknown function, DUF480
IXO74_011980	COG0210	DNA helicase
IXO74_012000	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO74_012025	COG1028	Short-chain dehydrogenase reductase Sdr
IXO74_012050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO74_012115	COG1166	arginine decarboxylase activity
IXO74_012120	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO74_012160	COG0606	chelatase, subunit chli
IXO74_012205	COG0366	Alpha amylase catalytic
IXO74_012210	COG0366	Alpha amylase catalytic
IXO74_012235	COG1609	Transcriptional regulator
IXO74_012275	COG0493	'glutamate synthase
IXO74_012280	COG0070	glutamate synthase
IXO74_012280	COG0069	glutamate synthase activity
IXO74_012280	COG0067	glutamate synthase
IXO74_012340	COG1111	helicase
IXO74_012340	COG1205	dead DEAH box helicase
IXO74_012345	COG1272	protein, Hemolysin III
IXO74_012390	COG1136	(ABC) transporter
IXO74_012425	COG1136	(ABC) transporter
IXO74_012470	COG3039	Transposase
IXO74_012475	COG0513	Belongs to the DEAD box helicase family
IXO74_012545	COG1858	cytochrome C peroxidase
IXO74_012560	COG0702	epimerase
IXO74_012585	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO74_012605	COG1649	PFAM Uncharacterised BCR, COG1649
IXO74_012610	COG2354	Protein conserved in bacteria
IXO74_012615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO74_012630	COG1511	domain protein
IXO74_012630	COG3264	Mechanosensitive ion channel
IXO74_012705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO74_012810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO74_012820	COG0642	Histidine kinase
IXO74_012830	COG1090	epimerase
IXO74_012840	COG3039	Transposase
IXO74_012865	COG2826	transposase and inactivated derivatives, IS30 family
IXO74_012950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO74_012965	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO74_012985	COG1304	FMN binding
IXO74_012990	COG3039	Transposase
IXO74_013005	COG4772	TonB-dependent receptor
IXO74_013015	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO74_013025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO74_013035	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO74_013065	COG0501	Belongs to the peptidase M48B family
IXO74_013075	COG0187	DNA topoisomerase II activity
IXO74_013090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO74_013110	COG0726	polysaccharide deacetylase
IXO74_013115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IXO74_013120	COG0671	phosphoesterase, PA-phosphatase related
IXO74_013130	COG0584	glycerophosphoryl diester phosphodiesterase
IXO74_013145	COG0861	Integral membrane protein TerC family
IXO74_013150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO74_013165	COG2271	Major facilitator Superfamily
IXO74_013170	COG1929	Belongs to the glycerate kinase type-1 family
IXO74_013225	COG0477	Major facilitator Superfamily
IXO74_013250	COG0302	gtp cyclohydrolase
IXO74_013255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO74_013300	COG2234	aminopeptidase activity
IXO74_013310	COG4942	peptidase
IXO74_013315	COG0793	Belongs to the peptidase S41A family
IXO74_013370	COG0386	Belongs to the glutathione peroxidase family
IXO74_013380	COG1322	Protein conserved in bacteria
IXO74_013385	COG0531	amino acid
IXO74_013400	COG0210	DNA helicase
IXO74_013415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO74_013420	COG0583	DNA-binding transcription factor activity
IXO74_013425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO74_013435	COG2159	amidohydrolase
IXO74_013465	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO74_013470	COG3540	Alkaline phosphatase
IXO74_013480	COG2091	lysine biosynthetic process via aminoadipic acid
IXO74_013495	COG0708	Exodeoxyribonuclease III
IXO74_013510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO74_013515	COG3162	membrane
IXO74_013555	COG3507	Belongs to the glycosyl hydrolase 43 family
IXO74_013575	COG1028	Short-chain dehydrogenase reductase Sdr
IXO74_013580	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO74_013585	COG4948	Mandelate Racemase Muconate Lactonizing
IXO74_013590	COG4807	Protein conserved in bacteria
IXO74_013595	COG1643	Atp-dependent helicase
IXO74_013605	COG1187	pseudouridine synthase activity
IXO74_013615	COG0667	Aldo Keto reductase
IXO74_013620	COG2130	NADP-dependent
IXO74_013625	COG0656	L-ascorbic acid biosynthetic process
IXO74_013665	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO74_013675	COG1119	ATPase activity
IXO74_013690	COG0517	IMP dehydrogenase activity
IXO74_013690	COG1125	glycine betaine transport
IXO74_013705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO74_013710	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO74_013715	COG3550	peptidyl-serine autophosphorylation
IXO74_013720	COG1396	sequence-specific DNA binding
IXO74_013740	COG0489	protein tyrosine kinase activity
IXO74_013745	COG2062	phosphohistidine phosphatase, SixA
IXO74_013755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO74_013800	COG1968	undecaprenyl-diphosphatase activity
IXO74_013805	COG0174	glutamine synthetase
IXO74_013810	COG0347	Belongs to the P(II) protein family
IXO74_013815	COG0004	ammonium transporteR
IXO74_013820	COG3852	Histidine kinase
IXO74_013825	COG2204	response regulator
IXO74_013830	COG2032	superoxide dismutase activity
IXO74_013835	COG2032	superoxide dismutase activity
IXO74_013880	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO74_013885	COG1074	ATP-dependent DNA helicase activity
IXO74_013895	COG3549	Plasmid maintenance system killer
IXO74_013980	COG1764	response to oxidative stress
IXO74_013985	COG1846	Transcriptional regulator
IXO74_014025	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IXO74_014075	COG2211	Major facilitator Superfamily
IXO74_014095	COG3693	PFAM glycoside hydrolase, family 10
IXO74_014120	COG0246	Mannitol dehydrogenase
IXO74_014125	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO74_014135	COG4948	Mandelate Racemase Muconate Lactonizing
IXO74_014145	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO74_014160	COG0037	tRNA processing
IXO74_014165	COG2974	May be involved in recombination
IXO74_014190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO74_014200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO74_014210	COG0805	protein transport
IXO74_014220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO74_014220	COG0519	Catalyzes the synthesis of GMP from XMP
IXO74_014240	COG0752	glycyl-tRNA synthetase alpha subunit
IXO74_014250	COG0457	Tetratricopeptide repeat
IXO74_014255	COG4771	TonB-dependent receptor
IXO74_014270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO74_014280	COG0697	spore germination
IXO74_014290	COG0523	cobalamin synthesis protein
IXO74_014340	COG1960	acyl-CoA dehydrogenase activity
IXO74_014345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO74_014350	COG4770	biotin carboxylase activity
IXO74_014405	COG2072	flavoprotein involved in K transport
IXO74_014425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO74_014470	COG0084	hydrolase, TatD family'
IXO74_014485	COG0583	DNA-binding transcription factor activity
IXO74_014490	COG2814	Major facilitator Superfamily
IXO74_014500	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO74_014505	COG1902	pentaerythritol trinitrate reductase activity
IXO74_014535	COG0745	RESPONSE REGULATOR receiver
IXO74_014555	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO74_014560	COG0583	DNA-binding transcription factor activity
IXO74_014590	COG0702	epimerase
IXO74_014595	COG1733	regulation of RNA biosynthetic process
IXO74_014650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO74_014665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO74_014700	COG2911	Protein conserved in bacteria
IXO74_014705	COG0729	surface antigen
IXO74_014720	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IXO74_014725	COG3118	belongs to the thioredoxin family
IXO74_014735	COG2884	Cell division ATP-binding protein ftsE
IXO74_014745	COG3437	response regulator, receiver
IXO74_014750	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO74_014755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO74_014765	COG1252	NADH dehydrogenase
IXO74_014795	COG0459	protein refolding
IXO74_014805	COG4771	TonB-dependent receptor
IXO74_014820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO74_014855	COG3386	PFAM SMP-30 Gluconolaconase
IXO74_014870	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO74_014900	COG2353	YceI-like domain
IXO74_014960	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXO74_015000	COG0408	coproporphyrinogen oxidase activity
IXO74_015010	COG3039	Transposase
IXO74_015035	COG0129	dihydroxy-acid dehydratase activity
IXO74_015045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO74_015095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO74_015100	COG0318	PFAM AMP-dependent synthetase and ligase
IXO74_015105	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO74_015110	COG0596	Alpha beta hydrolase
IXO74_015125	COG3177	Filamentation induced by cAMP protein fic
IXO74_015130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO74_015145	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO74_015170	COG4191	Histidine kinase
IXO74_015180	COG0028	Belongs to the TPP enzyme family
IXO74_015195	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO74_015200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO74_015240	COG5383	Protein conserved in bacteria
IXO74_015255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO74_015260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO74_015265	COG1473	amidohydrolase
IXO74_015275	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO74_015275	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO74_015310	COG3039	Transposase
IXO74_015375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO74_015380	COG0134	indole-3-glycerol-phosphate synthase activity
IXO74_015390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO74_015395	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO74_015405	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO74_015410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO74_015415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO74_015465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO74_015480	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO74_015545	COG0358	DNA primase activity
IXO74_015550	COG1295	ribonuclease BN
IXO74_015560	COG1610	YqeY-like protein
IXO74_015570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO74_015575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO74_015615	COG2133	pyrroloquinoline quinone binding
IXO74_015620	COG4682	membrane
IXO74_015645	COG0531	amino acid
IXO74_015670	COG4948	Mandelate Racemase Muconate Lactonizing
IXO74_015680	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO74_015685	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO74_015755	COG0183	Belongs to the thiolase family
IXO74_015795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IXO74_015805	COG3483	tryptophan 2,3-dioxygenase activity
IXO74_015810	COG3104	oligopeptide transport
IXO74_015830	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO74_015840	COG1320	monovalent cation:proton antiporter activity
IXO74_015845	COG2212	antiporter activity
IXO74_015855	COG0651	ATP synthesis coupled electron transport
IXO74_015860	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO74_015865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO74_015865	COG2111	Na H antiporter
IXO74_015910	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO74_015920	COG0456	acetyltransferase
IXO74_015950	COG4221	oxidoreductase activity
IXO74_016005	COG0697	spore germination
IXO74_016010	COG4305	rare lipoprotein A
IXO74_016015	COG5297	Belongs to the glycosyl hydrolase family 6
IXO74_016020	COG1113	amino acid transport
IXO74_016030	COG0598	Magnesium transport protein CorA
IXO74_016100	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO74_016100	COG5297	Belongs to the glycosyl hydrolase family 6
IXO74_016105	COG0659	secondary active sulfate transmembrane transporter activity
IXO74_016145	COG3275	phosphorelay sensor kinase activity
IXO74_016155	COG0181	hydroxymethylbilane synthase activity
IXO74_016180	COG1505	serine-type exopeptidase activity
IXO74_016205	COG0436	Aminotransferase
IXO74_016235	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO74_016265	COG0308	aminopeptidase N
IXO74_016270	COG2199	diguanylate cyclase activity
IXO74_016320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO74_016325	COG1077	Cell shape determining protein MreB Mrl
IXO74_016330	COG1792	Involved in formation and maintenance of cell shape
IXO74_016345	COG0772	Belongs to the SEDS family
IXO74_016415	COG2951	lytic endotransglycosylase activity
IXO74_016420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO74_016425	COG1686	Belongs to the peptidase S11 family
IXO74_016435	COG2921	Belongs to the UPF0250 family
IXO74_016460	COG1051	belongs to the nudix hydrolase family
IXO74_016460	COG1056	cytidyltransferase-related domain
IXO74_016495	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO74_016500	COG0673	inositol 2-dehydrogenase activity
IXO74_016505	COG2823	Periplasmic or secreted lipoprotein
IXO74_016510	COG4251	negative regulation of phosphorylation
IXO74_016515	COG0784	Response regulator, receiver
IXO74_016520	COG4191	Histidine kinase
IXO74_016525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO74_016575	COG3250	beta-galactosidase activity
IXO74_016590	COG2188	Transcriptional regulator
IXO74_016600	COG1609	Transcriptional regulator
IXO74_016605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO74_016610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO74_016620	COG1215	transferase activity, transferring glycosyl groups
IXO74_016625	COG0726	polysaccharide deacetylase
IXO74_016625	COG1649	PFAM Uncharacterised BCR, COG1649
IXO74_016725	COG3039	Transposase
IXO74_016760	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO74_016775	COG2205	protein histidine kinase activity
IXO74_016825	COG2205	protein histidine kinase activity
IXO74_016875	COG0488	(ABC) transporter
IXO74_016895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO74_016915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO74_016915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO74_016935	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO74_016940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO74_016945	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO74_016965	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO74_016970	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO74_016980	COG2205	protein histidine kinase activity
IXO74_016985	COG0745	RESPONSE REGULATOR receiver
IXO74_016990	COG0277	FAD linked oxidase domain protein
IXO74_016995	COG1988	membrane-bound metal-dependent
IXO74_017000	COG0792	nuclease activity
IXO74_017035	COG0275	rRNA processing
IXO74_017040	COG3116	cell division
IXO74_017055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO74_017060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO74_017075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO74_017080	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO74_017085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO74_017100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO74_017110	COG1388	LysM domain
IXO74_017110	COG4942	peptidase
IXO74_017125	COG0494	nUDIX hydrolase
IXO74_017140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO74_017150	COG0604	alcohol dehydrogenase
IXO74_017150	COG1028	Short-chain dehydrogenase reductase Sdr
IXO74_017150	COG3321	synthase
IXO74_017200	COG2226	methyltransferase
IXO74_017205	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO74_017260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO74_017275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO74_017285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO74_017290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO74_017300	COG0667	Aldo Keto reductase
IXO74_017355	COG2175	clavaminate synthase activity
IXO74_017370	COG4181	ATPase activity
IXO74_017385	COG0642	Histidine kinase
IXO74_017405	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO74_017425	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO74_017450	COG2967	ApaG domain
IXO74_017455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO74_017465	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO74_017480	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO74_017485	COG2096	Adenosyltransferase
IXO74_017495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO74_017500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO74_017540	COG0583	DNA-binding transcription factor activity
IXO74_017545	COG0318	PFAM AMP-dependent synthetase and ligase
IXO74_017555	COG1024	Enoyl-CoA hydratase
IXO74_017575	COG3386	PFAM SMP-30 Gluconolaconase
IXO74_017605	COG0697	spore germination
IXO74_017690	COG1902	pentaerythritol trinitrate reductase activity
IXO74_017690	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO74_017695	COG0604	alcohol dehydrogenase
IXO74_017720	COG0156	8-amino-7-oxononanoate synthase activity
IXO74_017725	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO74_017730	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO74_017735	COG4208	sulfate ABC transporter
IXO74_017740	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO74_017770	COG0588	phosphoglycerate mutase activity
IXO74_017780	COG0285	dihydrofolate synthase activity
IXO74_017800	COG2833	Protein of unknown function (DUF455)
IXO74_017820	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO74_017825	COG0671	phosphoesterase, PA-phosphatase related
IXO74_017830	COG0438	transferase activity, transferring glycosyl groups
IXO74_017840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO74_017855	COG4783	chaperone-mediated protein folding
IXO74_017880	COG0473	3-isopropylmalate dehydrogenase activity
IXO74_017930	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO74_017970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO74_018000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO74_018010	COG0631	protein serine/threonine phosphatase activity
IXO74_018065	COG0582	viral genome integration into host DNA
IXO74_018075	COG0859	PFAM glycosyl transferase family 9
IXO74_018080	COG3642	lipopolysaccharide core region biosynthetic process
IXO74_018085	COG1234	tRNA 3'-trailer cleavage
IXO74_018090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO74_018100	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO74_018105	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO74_018110	COG0314	molybdopterin synthase activity
IXO74_018140	COG0537	adenosine 5'-monophosphoramidase activity
IXO74_018160	COG0714	Associated with various cellular activities
IXO74_018180	COG0242	peptide deformylase activity
IXO74_018225	COG3039	Transposase
IXO74_018255	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO74_018260	COG0726	polysaccharide deacetylase
IXO74_018285	COG1162	GTPase activity
IXO74_018310	COG2211	Major facilitator Superfamily
IXO74_018320	COG1609	Transcriptional regulator
IXO74_018325	COG1028	Short-chain dehydrogenase reductase Sdr
IXO74_018330	COG2851	Citrate transporter
IXO74_018350	COG0642	Histidine kinase
IXO74_018360	COG2197	response regulator
IXO74_018375	COG0583	DNA-binding transcription factor activity
IXO74_018390	COG4191	Histidine kinase
IXO74_018410	COG0281	malic enzyme
IXO74_018410	COG0280	phosphate acetyltransferase
IXO74_018475	COG0352	thiamine-phosphate diphosphorylase activity
IXO74_018480	COG1773	rubredoxin
IXO74_018485	COG2912	Transglutaminase-like superfamily
IXO74_018495	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO74_018505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO74_018530	COG0006	proline dipeptidase activity
IXO74_018560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO74_018575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO74_018580	COG1561	YicC-like family, N-terminal region
IXO74_018605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO74_018615	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO74_018640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO74_018685	COG0714	Associated with various cellular activities
IXO74_018705	COG2304	oxidoreductase activity
IXO74_018725	COG1301	dicarboxylic acid transport
IXO74_018730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO74_018740	COG0739	heme binding
IXO74_018745	COG1376	ErfK ybiS ycfS ynhG family protein
IXO74_018770	COG1022	Amp-dependent synthetase and ligase
IXO74_018780	COG1028	Short-chain dehydrogenase reductase Sdr
IXO74_018795	COG0642	Histidine kinase
IXO74_018815	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO74_018820	COG4149	molybdate abc transporter
IXO74_018825	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO74_018830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO74_018830	COG3453	Protein conserved in bacteria
IXO74_018860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO74_018880	COG2205	protein histidine kinase activity
IXO74_018885	COG0745	RESPONSE REGULATOR receiver
IXO74_018935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO74_018940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO74_018985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO74_019005	COG2801	Transposase and inactivated derivatives
IXO74_019050	COG2201	protein-glutamate methylesterase activity
IXO74_019080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO74_019090	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXO74_019095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO74_019110	COG1842	Phage shock protein A
IXO74_019135	COG0754	glutathionylspermidine amidase activity
IXO74_019195	COG0531	amino acid
IXO74_019200	COG2197	response regulator
IXO74_019215	COG1113	amino acid transport
IXO74_019235	COG1271	oxidase subunit
IXO74_019240	COG1294	oxidase, subunit
IXO74_019250	COG2239	Acts as a magnesium transporter
IXO74_019255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO74_019260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO74_019275	COG1660	Displays ATPase and GTPase activities
IXO74_019280	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO74_019285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO74_019300	COG1137	ATPase activity
IXO74_019305	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO74_019315	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO74_019325	COG0271	Belongs to the BolA IbaG family
IXO74_019335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO74_019360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO74_019375	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO74_019385	COG0628	permease
IXO74_019395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO74_019400	COG3178	'Phosphotransferase
IXO74_019415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO74_019420	COG1555	photosystem II stabilization
IXO74_019470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO74_019480	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO74_019505	COG0228	four-way junction DNA binding
IXO74_019510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO74_019515	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO74_019530	COG0534	Mate efflux family protein
IXO74_019575	COG0542	response to heat
IXO74_019610	COG4206	TonB-dependent receptor
IXO74_019670	COG0019	diaminopimelate decarboxylase activity
IXO74_019685	COG4264	IucA IucC family
IXO74_019695	COG4772	TonB-dependent receptor
IXO74_019710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO74_019710	COG4651	solute:proton antiporter activity
IXO74_019740	COG0488	(ABC) transporter
IXO74_019765	COG2755	lipolytic protein G-D-S-L family
IXO74_019765	COG0657	acetylesterase activity
IXO74_019790	COG2207	Transcriptional regulator
IXO74_019795	COG0326	Molecular chaperone. Has ATPase activity
IXO74_019820	COG3328	transposase activity
IXO74_019825	COG0174	glutamine synthetase
IXO74_019830	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO74_019840	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO74_019855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO74_019880	COG2146	nitrite reductase [NAD(P)H] activity
IXO74_019895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO74_019900	COG0719	Fe-S assembly protein
IXO74_019905	COG0396	ATPase activity
IXO74_019910	COG0719	Fe-S assembly protein
IXO74_019915	COG1959	2 iron, 2 sulfur cluster binding
IXO74_019935	COG0693	protein deglycase activity
IXO74_019980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO74_020010	COG0519	Catalyzes the synthesis of GMP from XMP
IXO74_020020	COG1678	Uncharacterized ACR, COG1678
IXO74_020025	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO74_020040	COG1764	response to oxidative stress
IXO74_020050	COG0384	phenazine biosynthesis protein PhzF
IXO74_020060	COG0527	aspartate kinase activity
IXO74_020085	COG0142	geranyltranstransferase activity
IXO74_020090	COG0629	single-stranded DNA binding
IXO74_020095	COG3706	GGDEF domain
IXO74_020095	COG5001	Diguanylate cyclase
IXO74_020095	COG4251	negative regulation of phosphorylation
IXO74_020095	COG2203	Gaf domain
IXO74_020135	COG2879	small protein
IXO74_020145	COG1741	Belongs to the pirin family
IXO74_020210	COG1741	Belongs to the pirin family
IXO74_020220	COG1515	deoxyribonuclease V activity
IXO74_020225	COG0588	phosphoglycerate mutase activity
IXO74_020240	COG3590	peptidase
IXO74_020255	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO74_020260	COG2200	EAL domain
IXO74_020260	COG2199	diguanylate cyclase activity
IXO74_020260	COG2202	Pas domain
IXO74_020265	COG0835	chemotaxis
IXO74_020270	COG0840	transmembrane signaling receptor activity
IXO74_020275	COG0643	Histidine kinase
IXO74_020275	COG2198	Histidine kinase
IXO74_020290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO74_020300	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO74_020315	COG2205	protein histidine kinase activity
IXO74_020365	COG3039	Transposase
IXO74_020405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO74_020410	COG0735	belongs to the Fur family
IXO74_020470	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO74_020475	COG0084	hydrolase, TatD family'
IXO74_020490	COG1960	acyl-CoA dehydrogenase activity
IXO74_020505	COG0367	asparagine synthase
IXO74_020515	COG0305	Participates in initiation and elongation during chromosome replication
IXO74_020520	COG0415	Belongs to the DNA photolyase family
IXO74_020535	COG1028	Short-chain dehydrogenase reductase Sdr
IXO74_020635	COG5002	protein histidine kinase activity
IXO74_020635	COG5001	Diguanylate cyclase
IXO74_020640	COG1187	pseudouridine synthase activity
IXO74_020660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO74_020670	COG0475	glutathione-regulated potassium exporter activity
IXO74_020675	COG5000	phosphorelay sensor kinase activity
IXO74_020675	COG5002	protein histidine kinase activity
IXO74_020680	COG0745	RESPONSE REGULATOR receiver
IXO74_020710	COG1132	(ABC) transporter
IXO74_020780	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO74_020790	COG4969	Belongs to the N-Me-Phe pilin family
IXO74_020795	COG2194	sulfuric ester hydrolase activity
IXO74_020835	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO74_020840	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO74_020850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO74_020850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO74_020855	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO74_020860	COG0564	pseudouridine synthase activity
IXO74_020885	COG3387	PFAM Glycoside hydrolase 15-related
IXO74_020890	COG1877	trehalose-phosphatase activity
IXO74_020930	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO74_020945	COG1595	DNA-templated transcription, initiation
IXO74_020955	COG1946	Acyl-CoA thioesterase
IXO74_020970	COG0824	Thioesterase
IXO74_020975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO74_020985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO74_020990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO74_020995	COG0268	Binds directly to 16S ribosomal RNA
IXO74_021000	COG0728	peptidoglycan biosynthetic process
IXO74_021005	COG0196	riboflavin kinase activity
IXO74_021015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO74_021020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO74_021035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO74_021040	COG1845	cytochrome c oxidase, subunit III
IXO74_021045	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO74_021085	COG3209	COG3209 Rhs family protein
IXO74_021215	COG0632	four-way junction helicase activity
IXO74_021225	COG2255	four-way junction helicase activity
IXO74_021230	COG0824	Thioesterase
IXO74_021240	COG0848	biopolymer transport protein
IXO74_021255	COG2885	chlorophyll binding
IXO74_021265	COG0602	queuosine metabolic process
IXO74_021275	COG1187	pseudouridine synthase activity
IXO74_021325	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO74_021350	COG0514	ATP-dependent DNA helicase (RecQ)
IXO74_021355	COG0783	Belongs to the Dps family
IXO74_021360	COG1643	Atp-dependent helicase
IXO74_021385	COG0535	radical SAM domain protein
IXO74_021390	COG0535	radical SAM domain protein
IXO74_021410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO74_021420	COG1215	transferase activity, transferring glycosyl groups
IXO74_021425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO74_021435	COG1199	ATP-dependent helicase activity
IXO74_021445	COG1397	ADP-ribosylglycohydrolase
IXO74_021455	COG0189	ligase activity
IXO74_021470	COG0835	chemotaxis
IXO74_021475	COG0840	transmembrane signaling receptor activity
IXO74_021480	COG2198	Histidine kinase
IXO74_021480	COG0784	Response regulator, receiver
IXO74_021480	COG0643	Histidine kinase
IXO74_021525	COG1446	asparaginase
IXO74_021530	COG3142	Participates in the control of copper homeostasis
IXO74_021570	COG3537	Alpha-1,2-mannosidase
IXO74_021610	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO74_021630	COG3858	chitin binding
IXO74_021630	COG1388	LysM domain
IXO74_021645	COG0837	glucose binding
IXO74_021650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO74_021660	COG0494	nUDIX hydrolase
IXO74_021670	COG3956	TIGRFAM MazG family protein
IXO74_021685	COG0330	HflC and HflK could
IXO74_021700	COG0509	glycine decarboxylation via glycine cleavage system
IXO74_021730	COG1960	acyl-CoA dehydrogenase activity
IXO74_021740	COG1309	transcriptional regulator
IXO74_021745	COG4771	TonB-dependent receptor
IXO74_021755	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO74_021765	COG0463	Glycosyl transferase, family 2
IXO74_021785	COG1272	protein, Hemolysin III
IXO74_021795	COG0739	heme binding
IXO74_021800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO74_021805	COG0626	cystathionine gamma-synthase activity
IXO74_021815	COG1760	l-serine dehydratase
IXO74_021830	COG2353	YceI-like domain
IXO74_021840	COG2353	YceI-like domain
IXO74_021910	COG1960	acyl-CoA dehydrogenase activity
IXO74_021915	COG1024	Enoyl-CoA hydratase
IXO74_021935	COG1024	Enoyl-CoA hydratase
IXO74_021935	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO74_021950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO74_021980	COG1381	Involved in DNA repair and RecF pathway recombination
IXO74_021995	COG2954	triphosphatase activity
IXO74_022005	COG3039	Transposase
IXO74_022035	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO74_022045	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO74_022055	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO74_022060	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO74_022065	COG1278	Cold shock
IXO74_022085	COG1201	RNA secondary structure unwinding
IXO74_022090	COG1793	dna ligase
IXO74_022100	COG1793	dna ligase
IXO74_022100	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO74_022130	COG0183	Belongs to the thiolase family
IXO74_022150	COG1451	nucleotide metabolic process
IXO74_022165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO74_022210	COG1047	Peptidyl-prolyl cis-trans
IXO74_022225	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO74_022235	COG1902	pentaerythritol trinitrate reductase activity
IXO74_022240	COG2814	Major facilitator Superfamily
IXO74_022285	COG0392	lysyltransferase activity
IXO74_022285	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO74_022295	COG0251	oxidation-reduction process
IXO74_022300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO74_022315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO74_022340	COG1595	DNA-templated transcription, initiation
IXO74_022355	COG2878	Part of a membrane complex involved in electron transport
IXO74_022365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO74_022365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO74_022385	COG0833	amino acid
IXO74_022390	COG2040	homocysteine
IXO74_022405	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO74_022440	COG0529	Catalyzes the synthesis of activated sulfate
IXO74_022440	COG2895	sulfate adenylyltransferase (ATP) activity
IXO74_022485	COG1981	membrane
IXO74_022510	COG1131	(ABC) transporter
IXO74_022515	COG4771	TonB-dependent receptor
IXO74_022525	COG0825	malonyl-CoA metabolic process
IXO74_022545	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO74_022550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO74_022570	COG0750	zinc metalloprotease
IXO74_022580	COG0575	Belongs to the CDS family
IXO74_022590	COG0233	cytoplasmic translational termination
IXO74_022605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO74_022670	COG1393	Belongs to the ArsC family
IXO74_022685	COG0367	asparagine synthase
IXO74_022695	COG4774	siderophore transport
IXO74_022720	COG2207	Transcriptional regulator
IXO74_022735	COG1566	PFAM secretion protein HlyD family protein
IXO74_022740	COG2814	Major facilitator Superfamily
IXO74_022795	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO74_022805	COG1960	acyl-CoA dehydrogenase activity
IXO74_022820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO74_022830	COG2914	Belongs to the UPF0125 (RnfH) family
IXO74_022835	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO74_022845	COG0497	DNA recombination
IXO74_022855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO74_022860	COG0443	Heat shock 70 kDa protein
IXO74_022865	COG0484	heat shock protein binding
IXO74_022870	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO74_022875	COG0287	Prephenate dehydrogenase
IXO74_022875	COG1605	Chorismate mutase
IXO74_022890	COG0583	DNA-binding transcription factor activity
IXO74_022905	COG1132	(ABC) transporter
IXO74_022940	COG2850	peptidyl-arginine hydroxylation
IXO74_023000	COG1131	(ABC) transporter
IXO74_023005	COG1725	Transcriptional regulator
IXO74_023015	COG0386	Belongs to the glutathione peroxidase family
IXO74_023030	COG2900	Belongs to the SlyX family
IXO74_023045	COG1609	Transcriptional regulator
IXO74_023065	COG0646	methionine synthase
IXO74_023065	COG1410	methionine synthase
IXO74_023070	COG0646	methionine synthase
IXO74_023070	COG1410	methionine synthase
IXO74_023075	COG2226	methyltransferase
IXO74_023080	COG1960	acyl-CoA dehydrogenase activity
IXO74_023105	COG0557	exoribonuclease II activity
IXO74_023125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO74_023245	COG0583	DNA-binding transcription factor activity
IXO74_023315	COG4962	Type ii secretion system protein e
IXO74_023320	COG3838	Conjugal transfer protein Trbc
IXO74_023330	COG3451	type IV secretory pathway VirB4
IXO74_023345	COG3846	protein secretion by the type IV secretion system
IXO74_023380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO74_023515	COG0489	protein tyrosine kinase activity