locus-tag	class	description
IXO98_000015	COG2801	Transposase and inactivated derivatives
IXO98_000025	COG2201	protein-glutamate methylesterase activity
IXO98_000075	COG0653	protein targeting
IXO98_000165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXO98_000165	COG0140	phosphoribosyl-ATP diphosphatase activity
IXO98_000175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXO98_000185	COG0131	Imidazoleglycerol-phosphate dehydratase
IXO98_000185	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXO98_000200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IXO98_000220	COG0124	histidyl-tRNA synthetase
IXO98_000235	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXO98_000270	COG1012	belongs to the aldehyde dehydrogenase family
IXO98_000295	COG0697	spore germination
IXO98_000300	COG1794	racemase activity, acting on amino acids and derivatives
IXO98_000320	COG0671	phosphoesterase, PA-phosphatase related
IXO98_000335	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IXO98_000350	COG2183	response to ionizing radiation
IXO98_000360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO98_000360	COG0723	plastoquinol--plastocyanin reductase activity
IXO98_000375	COG3243	poly(R)-hydroxyalkanoic acid synthase
IXO98_000385	COG1183	phosphatidylcholine synthase activity
IXO98_000390	COG1028	Short-chain dehydrogenase reductase Sdr
IXO98_000415	COG0668	transmembrane transport
IXO98_000435	COG1914	H( )-stimulated, divalent metal cation uptake system
IXO98_000485	COG0583	DNA-binding transcription factor activity
IXO98_000490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO98_000495	COG3002	Belongs to the UPF0753 family
IXO98_000510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IXO98_000530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IXO98_000540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO98_000545	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXO98_000555	COG0776	regulation of translation
IXO98_000560	COG0539	negative regulation of cytoplasmic translation
IXO98_000565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXO98_000580	COG2957	Belongs to the agmatine deiminase family
IXO98_000590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO98_000615	COG0395	ABC-type sugar transport system, permease component
IXO98_000620	COG1175	transmembrane transport
IXO98_000650	COG2350	Protein conserved in bacteria
IXO98_000655	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IXO98_000660	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IXO98_000665	COG1187	pseudouridine synthase activity
IXO98_000690	COG0436	Aminotransferase
IXO98_000755	COG0277	FAD linked oxidase domain protein
IXO98_000760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXO98_000770	COG0531	amino acid
IXO98_000775	COG0531	amino acid
IXO98_000780	COG0235	Class ii aldolase
IXO98_000785	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IXO98_000815	COG2201	protein-glutamate methylesterase activity
IXO98_000860	COG0583	DNA-binding transcription factor activity
IXO98_000870	COG3039	Transposase
IXO98_000975	COG3039	Transposase
IXO98_000985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO98_001005	COG0557	exoribonuclease II activity
IXO98_001030	COG1960	acyl-CoA dehydrogenase activity
IXO98_001035	COG2226	methyltransferase
IXO98_001040	COG0646	methionine synthase
IXO98_001040	COG1410	methionine synthase
IXO98_001045	COG0646	methionine synthase
IXO98_001045	COG1410	methionine synthase
IXO98_001055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO98_001065	COG1609	Transcriptional regulator
IXO98_001080	COG2900	Belongs to the SlyX family
IXO98_001095	COG0386	Belongs to the glutathione peroxidase family
IXO98_001105	COG1725	Transcriptional regulator
IXO98_001110	COG1131	(ABC) transporter
IXO98_001175	COG2850	peptidyl-arginine hydroxylation
IXO98_001210	COG1132	(ABC) transporter
IXO98_001225	COG0583	DNA-binding transcription factor activity
IXO98_001240	COG0287	Prephenate dehydrogenase
IXO98_001240	COG1605	Chorismate mutase
IXO98_001245	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IXO98_001250	COG0484	heat shock protein binding
IXO98_001255	COG0443	Heat shock 70 kDa protein
IXO98_001260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXO98_001270	COG0497	DNA recombination
IXO98_001280	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO98_001285	COG2914	Belongs to the UPF0125 (RnfH) family
IXO98_001295	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IXO98_001310	COG1960	acyl-CoA dehydrogenase activity
IXO98_001320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXO98_001375	COG2814	Major facilitator Superfamily
IXO98_001380	COG1566	PFAM secretion protein HlyD family protein
IXO98_001395	COG2207	Transcriptional regulator
IXO98_001420	COG4774	siderophore transport
IXO98_001430	COG0367	asparagine synthase
IXO98_001445	COG1393	Belongs to the ArsC family
IXO98_001460	COG3039	Transposase
IXO98_001510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IXO98_001525	COG0233	cytoplasmic translational termination
IXO98_001535	COG0575	Belongs to the CDS family
IXO98_001545	COG0750	zinc metalloprotease
IXO98_001560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO98_001565	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO98_001585	COG0825	malonyl-CoA metabolic process
IXO98_001595	COG4771	TonB-dependent receptor
IXO98_001600	COG1131	(ABC) transporter
IXO98_001625	COG1981	membrane
IXO98_001670	COG2895	sulfate adenylyltransferase (ATP) activity
IXO98_001670	COG0529	Catalyzes the synthesis of activated sulfate
IXO98_001705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO98_001720	COG2040	homocysteine
IXO98_001725	COG0833	amino acid
IXO98_001745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO98_001745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXO98_001755	COG2878	Part of a membrane complex involved in electron transport
IXO98_001770	COG1595	DNA-templated transcription, initiation
IXO98_001795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO98_001810	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXO98_001815	COG0251	oxidation-reduction process
IXO98_001825	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IXO98_001825	COG0392	lysyltransferase activity
IXO98_001855	COG3039	Transposase
IXO98_001870	COG2814	Major facilitator Superfamily
IXO98_001875	COG1902	pentaerythritol trinitrate reductase activity
IXO98_001885	COG2824	Alkylphosphonate utilization operon protein PhnA
IXO98_001900	COG1047	Peptidyl-prolyl cis-trans
IXO98_001940	COG3039	Transposase
IXO98_001950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXO98_001965	COG1451	nucleotide metabolic process
IXO98_001985	COG0183	Belongs to the thiolase family
IXO98_002015	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXO98_002015	COG1793	dna ligase
IXO98_002025	COG1793	dna ligase
IXO98_002030	COG1201	RNA secondary structure unwinding
IXO98_002050	COG1278	Cold shock
IXO98_002055	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IXO98_002060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IXO98_002070	COG3046	protein related to deoxyribodipyrimidine photolyase
IXO98_002080	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IXO98_002105	COG3039	Transposase
IXO98_002115	COG2954	triphosphatase activity
IXO98_002130	COG1381	Involved in DNA repair and RecF pathway recombination
IXO98_002160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO98_002175	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO98_002175	COG1024	Enoyl-CoA hydratase
IXO98_002195	COG1024	Enoyl-CoA hydratase
IXO98_002200	COG1960	acyl-CoA dehydrogenase activity
IXO98_002270	COG2353	YceI-like domain
IXO98_002280	COG2353	YceI-like domain
IXO98_002295	COG1760	l-serine dehydratase
IXO98_002305	COG0626	cystathionine gamma-synthase activity
IXO98_002310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO98_002315	COG0739	heme binding
IXO98_002325	COG1272	protein, Hemolysin III
IXO98_002345	COG0463	Glycosyl transferase, family 2
IXO98_002355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXO98_002365	COG4771	TonB-dependent receptor
IXO98_002370	COG1309	transcriptional regulator
IXO98_002380	COG1960	acyl-CoA dehydrogenase activity
IXO98_002410	COG0509	glycine decarboxylation via glycine cleavage system
IXO98_002425	COG0330	HflC and HflK could
IXO98_002440	COG3956	TIGRFAM MazG family protein
IXO98_002450	COG0494	nUDIX hydrolase
IXO98_002460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXO98_002465	COG0837	glucose binding
IXO98_002480	COG1388	LysM domain
IXO98_002480	COG3858	chitin binding
IXO98_002490	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IXO98_002500	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO98_002560	COG3537	Alpha-1,2-mannosidase
IXO98_002600	COG3142	Participates in the control of copper homeostasis
IXO98_002605	COG1446	asparaginase
IXO98_002630	COG3039	Transposase
IXO98_002650	COG2198	Histidine kinase
IXO98_002650	COG0784	Response regulator, receiver
IXO98_002650	COG0643	Histidine kinase
IXO98_002655	COG0840	transmembrane signaling receptor activity
IXO98_002660	COG0835	chemotaxis
IXO98_002675	COG0189	ligase activity
IXO98_002685	COG1397	ADP-ribosylglycohydrolase
IXO98_002695	COG1199	ATP-dependent helicase activity
IXO98_002705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXO98_002710	COG1215	transferase activity, transferring glycosyl groups
IXO98_002720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO98_002740	COG0535	radical SAM domain protein
IXO98_002745	COG0535	radical SAM domain protein
IXO98_002770	COG1643	Atp-dependent helicase
IXO98_002775	COG0783	Belongs to the Dps family
IXO98_002780	COG0514	ATP-dependent DNA helicase (RecQ)
IXO98_002800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IXO98_002850	COG1187	pseudouridine synthase activity
IXO98_002855	COG0602	queuosine metabolic process
IXO98_002865	COG2885	chlorophyll binding
IXO98_002880	COG0848	biopolymer transport protein
IXO98_002890	COG0824	Thioesterase
IXO98_002895	COG2255	four-way junction helicase activity
IXO98_002905	COG0632	four-way junction helicase activity
IXO98_003035	COG3209	COG3209 Rhs family protein
IXO98_003055	COG3209	COG3209 Rhs family protein
IXO98_003055	COG3209	COG3209 Rhs family protein
IXO98_003075	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXO98_003080	COG1845	cytochrome c oxidase, subunit III
IXO98_003085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXO98_003100	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXO98_003105	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IXO98_003115	COG0196	riboflavin kinase activity
IXO98_003120	COG0728	peptidoglycan biosynthetic process
IXO98_003125	COG0268	Binds directly to 16S ribosomal RNA
IXO98_003130	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXO98_003135	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IXO98_003145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXO98_003150	COG0824	Thioesterase
IXO98_003165	COG1946	Acyl-CoA thioesterase
IXO98_003175	COG1595	DNA-templated transcription, initiation
IXO98_003190	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXO98_003230	COG1877	trehalose-phosphatase activity
IXO98_003235	COG3387	PFAM Glycoside hydrolase 15-related
IXO98_003260	COG0564	pseudouridine synthase activity
IXO98_003265	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO98_003270	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IXO98_003270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXO98_003280	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IXO98_003285	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO98_003325	COG2194	sulfuric ester hydrolase activity
IXO98_003330	COG4969	Belongs to the N-Me-Phe pilin family
IXO98_003340	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IXO98_003360	COG3039	Transposase
IXO98_003380	COG3039	Transposase
IXO98_003415	COG1132	(ABC) transporter
IXO98_003445	COG0745	RESPONSE REGULATOR receiver
IXO98_003450	COG5000	phosphorelay sensor kinase activity
IXO98_003450	COG5002	protein histidine kinase activity
IXO98_003455	COG0475	glutathione-regulated potassium exporter activity
IXO98_003465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO98_003485	COG1187	pseudouridine synthase activity
IXO98_003490	COG5002	protein histidine kinase activity
IXO98_003490	COG5001	Diguanylate cyclase
IXO98_003595	COG1028	Short-chain dehydrogenase reductase Sdr
IXO98_003610	COG0415	Belongs to the DNA photolyase family
IXO98_003615	COG0305	Participates in initiation and elongation during chromosome replication
IXO98_003625	COG0367	asparagine synthase
IXO98_003650	COG1960	acyl-CoA dehydrogenase activity
IXO98_003665	COG0084	hydrolase, TatD family'
IXO98_003670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXO98_003730	COG0735	belongs to the Fur family
IXO98_003735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXO98_003750	COG3039	Transposase
IXO98_003775	COG3039	Transposase
IXO98_003820	COG2205	protein histidine kinase activity
IXO98_003830	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXO98_003840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IXO98_003855	COG0643	Histidine kinase
IXO98_003855	COG2198	Histidine kinase
IXO98_003860	COG0840	transmembrane signaling receptor activity
IXO98_003865	COG0835	chemotaxis
IXO98_003870	COG2199	diguanylate cyclase activity
IXO98_003870	COG2200	EAL domain
IXO98_003870	COG2202	Pas domain
IXO98_003875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXO98_003890	COG3590	peptidase
IXO98_003905	COG0588	phosphoglycerate mutase activity
IXO98_003910	COG1515	deoxyribonuclease V activity
IXO98_003920	COG1741	Belongs to the pirin family
IXO98_003985	COG1741	Belongs to the pirin family
IXO98_003990	COG1966	Carbon starvation protein
IXO98_003995	COG2879	small protein
IXO98_004035	COG5001	Diguanylate cyclase
IXO98_004035	COG2203	Gaf domain
IXO98_004035	COG4251	negative regulation of phosphorylation
IXO98_004035	COG3706	GGDEF domain
IXO98_004040	COG0629	single-stranded DNA binding
IXO98_004045	COG0142	geranyltranstransferase activity
IXO98_004070	COG0527	aspartate kinase activity
IXO98_004080	COG0384	phenazine biosynthesis protein PhzF
IXO98_004090	COG1764	response to oxidative stress
IXO98_004105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXO98_004110	COG1678	Uncharacterized ACR, COG1678
IXO98_004120	COG0519	Catalyzes the synthesis of GMP from XMP
IXO98_004150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXO98_004190	COG0693	protein deglycase activity
IXO98_004210	COG1959	2 iron, 2 sulfur cluster binding
IXO98_004215	COG0719	Fe-S assembly protein
IXO98_004220	COG0396	ATPase activity
IXO98_004225	COG0719	Fe-S assembly protein
IXO98_004230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXO98_004240	COG2146	nitrite reductase [NAD(P)H] activity
IXO98_004265	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO98_004280	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO98_004290	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXO98_004295	COG0174	glutamine synthetase
IXO98_004300	COG3328	transposase activity
IXO98_004325	COG0326	Molecular chaperone. Has ATPase activity
IXO98_004330	COG2207	Transcriptional regulator
IXO98_004355	COG2755	lipolytic protein G-D-S-L family
IXO98_004355	COG0657	acetylesterase activity
IXO98_004380	COG0488	(ABC) transporter
IXO98_004415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXO98_004415	COG4651	solute:proton antiporter activity
IXO98_004430	COG4772	TonB-dependent receptor
IXO98_004440	COG4264	IucA IucC family
IXO98_004445	COG2814	Major facilitator Superfamily
IXO98_004455	COG0019	diaminopimelate decarboxylase activity
IXO98_004515	COG4206	TonB-dependent receptor
IXO98_004550	COG0542	response to heat
IXO98_004590	COG0534	Mate efflux family protein
IXO98_004605	COG0336	Belongs to the RNA methyltransferase TrmD family
IXO98_004610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXO98_004615	COG0228	four-way junction DNA binding
IXO98_004635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXO98_004645	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO98_004690	COG1555	photosystem II stabilization
IXO98_004695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO98_004710	COG3178	'Phosphotransferase
IXO98_004715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IXO98_004725	COG0628	permease
IXO98_004735	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXO98_004750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXO98_004770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IXO98_004775	COG0271	Belongs to the BolA IbaG family
IXO98_004785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXO98_004795	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXO98_004800	COG1137	ATPase activity
IXO98_004815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO98_004820	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IXO98_004825	COG1660	Displays ATPase and GTPase activities
IXO98_004835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO98_004840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO98_004845	COG2239	Acts as a magnesium transporter
IXO98_004855	COG1294	oxidase, subunit
IXO98_004860	COG1271	oxidase subunit
IXO98_004875	COG1113	amino acid transport
IXO98_004890	COG2197	response regulator
IXO98_004895	COG0531	amino acid
IXO98_004950	COG0754	glutathionylspermidine amidase activity
IXO98_004975	COG1842	Phage shock protein A
IXO98_004990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IXO98_004995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXO98_005005	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IXO98_005035	COG2201	protein-glutamate methylesterase activity
IXO98_005075	COG2801	Transposase and inactivated derivatives
IXO98_005090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXO98_005140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXO98_005145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO98_005170	COG3039	Transposase
IXO98_005185	COG0745	RESPONSE REGULATOR receiver
IXO98_005190	COG2205	protein histidine kinase activity
IXO98_005210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXO98_005240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO98_005240	COG3453	Protein conserved in bacteria
IXO98_005245	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXO98_005250	COG4149	molybdate abc transporter
IXO98_005255	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXO98_005275	COG0642	Histidine kinase
IXO98_005290	COG1028	Short-chain dehydrogenase reductase Sdr
IXO98_005300	COG1022	Amp-dependent synthetase and ligase
IXO98_005325	COG1376	ErfK ybiS ycfS ynhG family protein
IXO98_005330	COG0739	heme binding
IXO98_005340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXO98_005345	COG1301	dicarboxylic acid transport
IXO98_005365	COG2304	oxidoreductase activity
IXO98_005385	COG0714	Associated with various cellular activities
IXO98_005430	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXO98_005455	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXO98_005465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXO98_005490	COG1561	YicC-like family, N-terminal region
IXO98_005495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXO98_005510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXO98_005545	COG0006	proline dipeptidase activity
IXO98_005570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXO98_005580	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXO98_005590	COG2912	Transglutaminase-like superfamily
IXO98_005595	COG1773	rubredoxin
IXO98_005600	COG0352	thiamine-phosphate diphosphorylase activity
IXO98_005670	COG0280	phosphate acetyltransferase
IXO98_005670	COG0281	malic enzyme
IXO98_005690	COG4191	Histidine kinase
IXO98_005705	COG0583	DNA-binding transcription factor activity
IXO98_005720	COG2197	response regulator
IXO98_005730	COG0642	Histidine kinase
IXO98_005750	COG2851	Citrate transporter
IXO98_005755	COG1028	Short-chain dehydrogenase reductase Sdr
IXO98_005760	COG1609	Transcriptional regulator
IXO98_005770	COG2211	Major facilitator Superfamily
IXO98_005795	COG1162	GTPase activity
IXO98_005820	COG0726	polysaccharide deacetylase
IXO98_005825	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO98_005850	COG3039	Transposase
IXO98_005855	COG3039	Transposase
IXO98_005900	COG0242	peptide deformylase activity
IXO98_005920	COG0714	Associated with various cellular activities
IXO98_005940	COG0537	adenosine 5'-monophosphoramidase activity
IXO98_005970	COG0314	molybdopterin synthase activity
IXO98_005975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXO98_005980	COG0315	cyclic pyranopterin monophosphate synthase activity
IXO98_005990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXO98_005995	COG1234	tRNA 3'-trailer cleavage
IXO98_006000	COG3642	lipopolysaccharide core region biosynthetic process
IXO98_006005	COG0859	PFAM glycosyl transferase family 9
IXO98_006015	COG0582	viral genome integration into host DNA
IXO98_006070	COG0631	protein serine/threonine phosphatase activity
IXO98_006080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO98_006105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXO98_006145	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXO98_006195	COG0473	3-isopropylmalate dehydrogenase activity
IXO98_006220	COG4783	chaperone-mediated protein folding
IXO98_006235	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXO98_006245	COG0438	transferase activity, transferring glycosyl groups
IXO98_006250	COG0671	phosphoesterase, PA-phosphatase related
IXO98_006255	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXO98_006275	COG2833	Protein of unknown function (DUF455)
IXO98_006295	COG0285	dihydrofolate synthase activity
IXO98_006305	COG0588	phosphoglycerate mutase activity
IXO98_006335	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IXO98_006340	COG4208	sulfate ABC transporter
IXO98_006345	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IXO98_006350	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IXO98_006355	COG0156	8-amino-7-oxononanoate synthase activity
IXO98_006380	COG0604	alcohol dehydrogenase
IXO98_006385	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXO98_006385	COG1902	pentaerythritol trinitrate reductase activity
IXO98_006475	COG0697	spore germination
IXO98_006505	COG3386	PFAM SMP-30 Gluconolaconase
IXO98_006525	COG1024	Enoyl-CoA hydratase
IXO98_006535	COG0318	PFAM AMP-dependent synthetase and ligase
IXO98_006540	COG0583	DNA-binding transcription factor activity
IXO98_006580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO98_006585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXO98_006595	COG2096	Adenosyltransferase
IXO98_006600	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXO98_006615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXO98_006625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IXO98_006630	COG2967	ApaG domain
IXO98_006655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXO98_006675	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXO98_006700	COG0642	Histidine kinase
IXO98_006715	COG4181	ATPase activity
IXO98_006725	COG2175	clavaminate synthase activity
IXO98_006780	COG0667	Aldo Keto reductase
IXO98_006800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXO98_006805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO98_006815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO98_006830	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXO98_006875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IXO98_006880	COG2226	methyltransferase
IXO98_006925	COG0604	alcohol dehydrogenase
IXO98_006925	COG1028	Short-chain dehydrogenase reductase Sdr
IXO98_006925	COG3321	synthase
IXO98_006935	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXO98_006950	COG0494	nUDIX hydrolase
IXO98_006965	COG1388	LysM domain
IXO98_006965	COG4942	peptidase
IXO98_006975	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXO98_006990	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXO98_006995	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO98_007000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO98_007015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IXO98_007020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXO98_007035	COG3116	cell division
IXO98_007040	COG0275	rRNA processing
IXO98_007075	COG0792	nuclease activity
IXO98_007080	COG1988	membrane-bound metal-dependent
IXO98_007085	COG0277	FAD linked oxidase domain protein
IXO98_007090	COG0745	RESPONSE REGULATOR receiver
IXO98_007095	COG2205	protein histidine kinase activity
IXO98_007105	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IXO98_007110	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IXO98_007130	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IXO98_007135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO98_007140	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IXO98_007160	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO98_007160	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXO98_007180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXO98_007200	COG0488	(ABC) transporter
IXO98_007210	COG3039	Transposase
IXO98_007255	COG2205	protein histidine kinase activity
IXO98_007300	COG2205	protein histidine kinase activity
IXO98_007315	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXO98_007350	COG3039	Transposase
IXO98_007370	COG3039	Transposase
IXO98_007450	COG0726	polysaccharide deacetylase
IXO98_007450	COG1649	PFAM Uncharacterised BCR, COG1649
IXO98_007455	COG1215	transferase activity, transferring glycosyl groups
IXO98_007465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXO98_007470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO98_007475	COG1609	Transcriptional regulator
IXO98_007485	COG2188	Transcriptional regulator
IXO98_007500	COG3250	beta-galactosidase activity
IXO98_007550	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXO98_007555	COG4191	Histidine kinase
IXO98_007560	COG0784	Response regulator, receiver
IXO98_007565	COG4251	negative regulation of phosphorylation
IXO98_007570	COG2823	Periplasmic or secreted lipoprotein
IXO98_007575	COG0673	inositol 2-dehydrogenase activity
IXO98_007580	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IXO98_007615	COG1051	belongs to the nudix hydrolase family
IXO98_007615	COG1056	cytidyltransferase-related domain
IXO98_007640	COG2921	Belongs to the UPF0250 family
IXO98_007655	COG1686	Belongs to the peptidase S11 family
IXO98_007660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXO98_007665	COG2951	lytic endotransglycosylase activity
IXO98_007735	COG0772	Belongs to the SEDS family
IXO98_007750	COG1792	Involved in formation and maintenance of cell shape
IXO98_007755	COG1077	Cell shape determining protein MreB Mrl
IXO98_007760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO98_007810	COG2199	diguanylate cyclase activity
IXO98_007815	COG0308	aminopeptidase N
IXO98_007845	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXO98_007875	COG0436	Aminotransferase
IXO98_007900	COG1505	serine-type exopeptidase activity
IXO98_007925	COG0181	hydroxymethylbilane synthase activity
IXO98_007935	COG3275	phosphorelay sensor kinase activity
IXO98_007970	COG0659	secondary active sulfate transmembrane transporter activity
IXO98_007975	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO98_007975	COG5297	Belongs to the glycosyl hydrolase family 6
IXO98_008050	COG0598	Magnesium transport protein CorA
IXO98_008060	COG1113	amino acid transport
IXO98_008070	COG5297	Belongs to the glycosyl hydrolase family 6
IXO98_008075	COG4305	rare lipoprotein A
IXO98_008080	COG0697	spore germination
IXO98_008140	COG4221	oxidoreductase activity
IXO98_008170	COG0456	acetyltransferase
IXO98_008180	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXO98_008225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IXO98_008225	COG2111	Na H antiporter
IXO98_008230	COG1006	Multisubunit Na H antiporter MnhC subunit
IXO98_008235	COG0651	ATP synthesis coupled electron transport
IXO98_008245	COG2212	antiporter activity
IXO98_008250	COG1320	monovalent cation:proton antiporter activity
IXO98_008260	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXO98_008280	COG3104	oligopeptide transport
IXO98_008285	COG3483	tryptophan 2,3-dioxygenase activity
IXO98_008295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IXO98_008335	COG0183	Belongs to the thiolase family
IXO98_008405	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IXO98_008410	COG3023	N-Acetylmuramoyl-L-alanine amidase
IXO98_008420	COG4948	Mandelate Racemase Muconate Lactonizing
IXO98_008445	COG0531	amino acid
IXO98_008475	COG4682	membrane
IXO98_008480	COG2133	pyrroloquinoline quinone binding
IXO98_008520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXO98_008525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXO98_008535	COG1610	YqeY-like protein
IXO98_008545	COG1295	ribonuclease BN
IXO98_008550	COG0358	DNA primase activity
IXO98_008615	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXO98_008630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXO98_008680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IXO98_008685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IXO98_008690	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IXO98_008700	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IXO98_008705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXO98_008715	COG0134	indole-3-glycerol-phosphate synthase activity
IXO98_008720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXO98_008795	COG3039	Transposase
IXO98_008815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO98_008815	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXO98_008825	COG1473	amidohydrolase
IXO98_008830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO98_008835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO98_008845	COG5383	Protein conserved in bacteria
IXO98_008880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXO98_008885	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IXO98_008900	COG0028	Belongs to the TPP enzyme family
IXO98_008905	COG4191	Histidine kinase
IXO98_008930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXO98_008945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO98_008950	COG3177	Filamentation induced by cAMP protein fic
IXO98_008965	COG0596	Alpha beta hydrolase
IXO98_008970	COG0727	PFAM Uncharacterised protein family (UPF0153)
IXO98_008975	COG0318	PFAM AMP-dependent synthetase and ligase
IXO98_008980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXO98_009030	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXO98_009040	COG0129	dihydroxy-acid dehydratase activity
IXO98_009060	COG3039	Transposase
IXO98_009070	COG0408	coproporphyrinogen oxidase activity
IXO98_009110	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXO98_009170	COG2353	YceI-like domain
IXO98_009175	COG0778	Nitroreductase
IXO98_009210	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXO98_009225	COG3386	PFAM SMP-30 Gluconolaconase
IXO98_009265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXO98_009285	COG0459	protein refolding
IXO98_009310	COG1252	NADH dehydrogenase
IXO98_009320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO98_009325	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXO98_009330	COG2201	protein-glutamate methylesterase activity
IXO98_009335	COG2177	Part of the ABC transporter FtsEX involved in
IXO98_009340	COG2884	Cell division ATP-binding protein ftsE
IXO98_009350	COG3118	belongs to the thioredoxin family
IXO98_009370	COG0729	surface antigen
IXO98_009375	COG2911	Protein conserved in bacteria
IXO98_009410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXO98_009425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO98_009475	COG1733	regulation of RNA biosynthetic process
IXO98_009480	COG0702	epimerase
IXO98_009510	COG0583	DNA-binding transcription factor activity
IXO98_009515	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO98_009535	COG0745	RESPONSE REGULATOR receiver
IXO98_009565	COG1902	pentaerythritol trinitrate reductase activity
IXO98_009570	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXO98_009580	COG2814	Major facilitator Superfamily
IXO98_009585	COG0583	DNA-binding transcription factor activity
IXO98_009600	COG0084	hydrolase, TatD family'
IXO98_009645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXO98_009665	COG2072	flavoprotein involved in K transport
IXO98_009725	COG4770	biotin carboxylase activity
IXO98_009730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXO98_009735	COG1960	acyl-CoA dehydrogenase activity
IXO98_009785	COG0523	cobalamin synthesis protein
IXO98_009795	COG0697	spore germination
IXO98_009805	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXO98_009820	COG4771	TonB-dependent receptor
IXO98_009825	COG0457	Tetratricopeptide repeat
IXO98_009835	COG0752	glycyl-tRNA synthetase alpha subunit
IXO98_009840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO98_009855	COG0519	Catalyzes the synthesis of GMP from XMP
IXO98_009855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXO98_009865	COG0805	protein transport
IXO98_009875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXO98_009885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXO98_009910	COG2974	May be involved in recombination
IXO98_009915	COG0037	tRNA processing
IXO98_009930	COG3661	Belongs to the glycosyl hydrolase 67 family
IXO98_009940	COG4948	Mandelate Racemase Muconate Lactonizing
IXO98_009950	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO98_009955	COG0246	Mannitol dehydrogenase
IXO98_009980	COG3693	PFAM glycoside hydrolase, family 10
IXO98_010000	COG2211	Major facilitator Superfamily
IXO98_010045	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IXO98_010085	COG1846	Transcriptional regulator
IXO98_010090	COG1764	response to oxidative stress
IXO98_010165	COG3549	Plasmid maintenance system killer
IXO98_010175	COG1074	ATP-dependent DNA helicase activity
IXO98_010180	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXO98_010225	COG2032	superoxide dismutase activity
IXO98_010230	COG2032	superoxide dismutase activity
IXO98_010235	COG2204	response regulator
IXO98_010240	COG3852	Histidine kinase
IXO98_010245	COG0004	ammonium transporteR
IXO98_010250	COG0347	Belongs to the P(II) protein family
IXO98_010255	COG0174	glutamine synthetase
IXO98_010260	COG1968	undecaprenyl-diphosphatase activity
IXO98_010305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO98_010315	COG2062	phosphohistidine phosphatase, SixA
IXO98_010320	COG0489	protein tyrosine kinase activity
IXO98_010340	COG1396	sequence-specific DNA binding
IXO98_010345	COG3550	peptidyl-serine autophosphorylation
IXO98_010350	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IXO98_010355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO98_010370	COG0517	IMP dehydrogenase activity
IXO98_010370	COG1125	glycine betaine transport
IXO98_010385	COG1119	ATPase activity
IXO98_010395	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXO98_010410	COG3039	Transposase
IXO98_010435	COG0656	L-ascorbic acid biosynthetic process
IXO98_010440	COG2130	NADP-dependent
IXO98_010445	COG0667	Aldo Keto reductase
IXO98_010455	COG1187	pseudouridine synthase activity
IXO98_010465	COG1643	Atp-dependent helicase
IXO98_010470	COG4807	Protein conserved in bacteria
IXO98_010475	COG4948	Mandelate Racemase Muconate Lactonizing
IXO98_010480	COG0179	Fumarylacetoacetate (FAA) hydrolase
IXO98_010485	COG1028	Short-chain dehydrogenase reductase Sdr
IXO98_010505	COG3507	Belongs to the glycosyl hydrolase 43 family
IXO98_010545	COG3162	membrane
IXO98_010550	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXO98_010565	COG0708	Exodeoxyribonuclease III
IXO98_010580	COG2091	lysine biosynthetic process via aminoadipic acid
IXO98_010590	COG3540	Alkaline phosphatase
IXO98_010595	COG0357	Ribosomal RNA small subunit methyltransferase G
IXO98_010620	COG2159	amidohydrolase
IXO98_010630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXO98_010635	COG0583	DNA-binding transcription factor activity
IXO98_010640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO98_010655	COG0210	DNA helicase
IXO98_010675	COG0531	amino acid
IXO98_010680	COG1322	Protein conserved in bacteria
IXO98_010690	COG0386	Belongs to the glutathione peroxidase family
IXO98_010745	COG0793	Belongs to the peptidase S41A family
IXO98_010750	COG4942	peptidase
IXO98_010760	COG2234	aminopeptidase activity
IXO98_010805	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXO98_010810	COG0302	gtp cyclohydrolase
IXO98_010830	COG0477	Major facilitator Superfamily
IXO98_010845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO98_010910	COG1929	Belongs to the glycerate kinase type-1 family
IXO98_010915	COG2271	Major facilitator Superfamily
IXO98_010930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO98_010935	COG0861	Integral membrane protein TerC family
IXO98_010950	COG0584	glycerophosphoryl diester phosphodiesterase
IXO98_010960	COG0671	phosphoesterase, PA-phosphatase related
IXO98_010965	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IXO98_010970	COG0726	polysaccharide deacetylase
IXO98_010990	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IXO98_011005	COG0187	DNA topoisomerase II activity
IXO98_011015	COG0501	Belongs to the peptidase M48B family
IXO98_011045	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXO98_011055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXO98_011065	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IXO98_011075	COG4772	TonB-dependent receptor
IXO98_011090	COG3039	Transposase
IXO98_011095	COG1304	FMN binding
IXO98_011115	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXO98_011125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXO98_011210	COG2826	transposase and inactivated derivatives, IS30 family
IXO98_011235	COG3039	Transposase
IXO98_011245	COG1090	epimerase
IXO98_011255	COG0642	Histidine kinase
IXO98_011265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXO98_011375	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IXO98_011450	COG1511	domain protein
IXO98_011450	COG3264	Mechanosensitive ion channel
IXO98_011465	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO98_011470	COG2354	Protein conserved in bacteria
IXO98_011475	COG1649	PFAM Uncharacterised BCR, COG1649
IXO98_011495	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXO98_011520	COG0702	epimerase
IXO98_011535	COG1858	cytochrome C peroxidase
IXO98_011605	COG0513	Belongs to the DEAD box helicase family
IXO98_011610	COG3039	Transposase
IXO98_011655	COG1136	(ABC) transporter
IXO98_011695	COG1136	(ABC) transporter
IXO98_011735	COG1272	protein, Hemolysin III
IXO98_011740	COG1111	helicase
IXO98_011740	COG1205	dead DEAH box helicase
IXO98_011800	COG0067	glutamate synthase
IXO98_011800	COG0069	glutamate synthase activity
IXO98_011800	COG0070	glutamate synthase
IXO98_011805	COG0493	'glutamate synthase
IXO98_011850	COG1609	Transcriptional regulator
IXO98_011880	COG0366	Alpha amylase catalytic
IXO98_011885	COG0366	Alpha amylase catalytic
IXO98_011930	COG0606	chelatase, subunit chli
IXO98_011970	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IXO98_011975	COG1166	arginine decarboxylase activity
IXO98_012040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IXO98_012065	COG1028	Short-chain dehydrogenase reductase Sdr
IXO98_012090	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IXO98_012105	COG0210	DNA helicase
IXO98_012120	COG3132	Protein of unknown function, DUF480
IXO98_012125	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IXO98_012130	COG0284	orotidine-5'-phosphate decarboxylase activity
IXO98_012165	COG2937	Belongs to the GPAT DAPAT family
IXO98_012205	COG3186	Phenylalanine-4-hydroxylase
IXO98_012210	COG1522	sequence-specific DNA binding
IXO98_012255	COG1064	alcohol dehydrogenase
IXO98_012260	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO98_012270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO98_012280	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXO98_012300	COG0676	glucose-6-phosphate 1-epimerase activity
IXO98_012365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IXO98_012390	COG2853	Lipoprotein
IXO98_012405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO98_012410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO98_012415	COG1127	ABC transporter
IXO98_012490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO98_012500	COG3039	Transposase
IXO98_012505	COG3265	gluconokinase activity
IXO98_012510	COG2211	Major facilitator Superfamily
IXO98_012515	COG3459	Glycosyltransferase 36 associated
IXO98_012525	COG2205	protein histidine kinase activity
IXO98_012535	COG1414	Transcriptional regulator
IXO98_012540	COG0738	Major facilitator superfamily
IXO98_012545	COG3254	rhamnose metabolic process
IXO98_012575	COG0339	signal peptide processing
IXO98_012600	COG0564	pseudouridine synthase activity
IXO98_012610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IXO98_012620	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXO98_012685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXO98_012695	COG0842	Transport permease protein
IXO98_012700	COG1131	(ABC) transporter
IXO98_012730	COG1476	TRANSCRIPTIONal
IXO98_012740	COG4555	ABC transporter
IXO98_012775	COG0625	glutathione transferase activity
IXO98_012820	COG0583	DNA-binding transcription factor activity
IXO98_012860	COG1199	ATP-dependent helicase activity
IXO98_012880	COG1566	PFAM secretion protein HlyD family protein
IXO98_012900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXO98_012940	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXO98_012940	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXO98_012945	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IXO98_012960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IXO98_012995	COG3237	CsbD-like
IXO98_013000	COG0180	Tryptophanyl-tRNA synthetase
IXO98_013005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXO98_013050	COG0753	catalase activity
IXO98_013065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO98_013075	COG0628	permease
IXO98_013085	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXO98_013090	COG1040	competence protein
IXO98_013095	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IXO98_013100	COG0156	8-amino-7-oxononanoate synthase activity
IXO98_013110	COG1028	Short-chain dehydrogenase reductase Sdr
IXO98_013125	COG0463	Glycosyl transferase, family 2
IXO98_013135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXO98_013140	COG3100	YcgL domain-containing protein
IXO98_013155	COG3387	PFAM Glycoside hydrolase 15-related
IXO98_013160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO98_013175	COG2239	Acts as a magnesium transporter
IXO98_013185	COG1042	CoA-binding domain protein
IXO98_013185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXO98_013185	COG0045	succinate-CoA ligase (ADP-forming) activity
IXO98_013195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO98_013200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXO98_013240	COG3485	protocatechuate 3,4-dioxygenase
IXO98_013260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO98_013265	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXO98_013290	COG4221	oxidoreductase activity
IXO98_013315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXO98_013340	COG0463	Glycosyl transferase, family 2
IXO98_013355	COG1475	DNA binding
IXO98_013360	COG1192	Involved in chromosome partitioning
IXO98_013375	COG0708	Exodeoxyribonuclease III
IXO98_013380	COG2211	Major facilitator Superfamily
IXO98_013395	COG0739	heme binding
IXO98_013440	COG0745	RESPONSE REGULATOR receiver
IXO98_013480	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IXO98_013495	COG2814	Major facilitator Superfamily
IXO98_013510	COG1289	transmembrane transporter activity
IXO98_013535	COG0151	Belongs to the GarS family
IXO98_013545	COG0138	bifunctional purine biosynthesis protein purh
IXO98_013560	COG3039	Transposase
IXO98_013565	COG2267	carboxylic ester hydrolase activity
IXO98_013570	COG2267	carboxylic ester hydrolase activity
IXO98_013590	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXO98_013635	COG0439	Biotin carboxylase
IXO98_013645	COG0511	ligase activity, forming carbon-carbon bonds
IXO98_013650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXO98_013660	COG1324	tolerance protein
IXO98_013695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXO98_013720	COG0534	Mate efflux family protein
IXO98_013725	COG0616	signal peptide processing
IXO98_013735	COG1028	Short-chain dehydrogenase reductase Sdr
IXO98_013750	COG0009	L-threonylcarbamoyladenylate synthase
IXO98_013755	COG1754	DNA topoisomerase type I activity
IXO98_013755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXO98_013770	COG2922	Belongs to the Smg family
IXO98_013775	COG0758	DNA mediated transformation
IXO98_013780	COG1652	LysM domain
IXO98_013785	COG0242	peptide deformylase activity
IXO98_013790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXO98_013795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXO98_013795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXO98_013845	COG1560	Kdo2-lipid A biosynthetic process
IXO98_013855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXO98_013995	COG3039	Transposase
IXO98_014005	COG1271	oxidase subunit
IXO98_014060	COG2972	Histidine kinase
IXO98_014075	COG0531	amino acid
IXO98_014095	COG3590	peptidase
IXO98_014110	COG0667	Aldo Keto reductase
IXO98_014125	COG3384	dioxygenase
IXO98_014135	COG1573	uracil-dna glycosylase
IXO98_014145	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXO98_014155	COG0025	NhaP-type Na H and K H
IXO98_014160	COG1131	(ABC) transporter
IXO98_014165	COG0842	Transport permease protein
IXO98_014180	COG1404	Belongs to the peptidase S8 family
IXO98_014195	COG0745	RESPONSE REGULATOR receiver
IXO98_014245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO98_014270	COG2205	protein histidine kinase activity
IXO98_014270	COG2202	Pas domain
IXO98_014300	COG2813	Specifically methylates the guanine in position
IXO98_014305	COG1187	pseudouridine synthase activity
IXO98_014310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXO98_014350	COG0697	spore germination
IXO98_014360	COG2011	ABC-type metal ion transport system permease component
IXO98_014390	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXO98_014400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXO98_014420	COG0356	it plays a direct role in the translocation of protons across the membrane
IXO98_014430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXO98_014440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IXO98_014445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXO98_014450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXO98_014455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXO98_014505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO98_014510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXO98_014560	COG0339	signal peptide processing
IXO98_014595	COG1956	GAF domain-containing protein
IXO98_014600	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXO98_014610	COG0720	synthase
IXO98_014615	COG0513	Belongs to the DEAD box helicase family
IXO98_014625	COG0625	glutathione transferase activity
IXO98_014655	COG0626	cystathionine gamma-synthase activity
IXO98_014695	COG3328	transposase activity
IXO98_014720	COG2086	electron transfer activity
IXO98_014745	COG0662	Cupin 2, conserved barrel domain protein
IXO98_014745	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IXO98_014750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO98_014785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXO98_014785	COG3218	ABC-type transport auxiliary lipoprotein component
IXO98_014790	COG1127	ABC transporter
IXO98_014795	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXO98_014815	COG0442	prolyl-tRNA aminoacylation
IXO98_014825	COG1183	phosphatidylcholine synthase activity
IXO98_014890	COG3039	Transposase
IXO98_014920	COG0525	valine-tRNA ligase activity
IXO98_014935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXO98_014945	COG0795	lipopolysaccharide-transporting ATPase activity
IXO98_014960	COG4974	Belongs to the 'phage' integrase family
IXO98_014965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXO98_014975	COG5295	Hep Hag repeat protein
IXO98_014985	COG1404	Belongs to the peptidase S8 family
IXO98_014995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXO98_015005	COG1459	type II secretion system
IXO98_015010	COG2165	general secretion pathway protein
IXO98_015015	COG4970	Tfp pilus assembly protein FimT
IXO98_015020	COG2165	general secretion pathway protein
IXO98_015025	COG4795	General secretion pathway protein
IXO98_015030	COG3156	type II secretion system protein K
IXO98_015035	COG3166	PFAM Fimbrial assembly family protein
IXO98_015050	COG1450	Type ii and iii secretion system protein
IXO98_015065	COG2188	Transcriptional regulator
IXO98_015115	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IXO98_015120	COG1518	maintenance of DNA repeat elements
IXO98_015155	COG3039	Transposase
IXO98_015170	COG1399	metal-binding, possibly nucleic acid-binding protein
IXO98_015195	COG1028	Short-chain dehydrogenase reductase Sdr
IXO98_015200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXO98_015210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXO98_015215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXO98_015245	COG3829	transcription factor binding
IXO98_015320	COG2826	transposase and inactivated derivatives, IS30 family
IXO98_015330	COG0678	peroxiredoxin activity
IXO98_015350	COG0330	HflC and HflK could
IXO98_015355	COG0330	HflC and HflK could
IXO98_015365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXO98_015370	COG0308	aminopeptidase N
IXO98_015430	COG1560	Kdo2-lipid A biosynthetic process
IXO98_015435	COG1519	Transferase
IXO98_015440	COG1538	Outer membrane efflux protein
IXO98_015445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO98_015475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IXO98_015480	COG0066	3-isopropylmalate dehydratase activity
IXO98_015485	COG2226	methyltransferase
IXO98_015515	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXO98_015525	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IXO98_015530	COG3710	Transcriptional regulator
IXO98_015555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IXO98_015575	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IXO98_015610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXO98_015620	COG3781	membrane
IXO98_015755	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IXO98_015775	COG1217	gtp-binding protein TYPA
IXO98_015780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXO98_015785	COG0039	L-malate dehydrogenase activity
IXO98_015790	COG0625	glutathione transferase activity
IXO98_015805	COG3039	Transposase
IXO98_015830	COG0584	glycerophosphoryl diester phosphodiesterase
IXO98_015865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXO98_015900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXO98_015905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO98_015910	COG0583	DNA-binding transcription factor activity
IXO98_015915	COG3634	alkyl hydroperoxide reductase activity
IXO98_015925	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO98_015965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO98_015965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXO98_015980	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXO98_016005	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXO98_016030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXO98_016040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXO98_016070	COG1295	ribonuclease BN
IXO98_016075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO98_016095	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXO98_016105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IXO98_016110	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXO98_016120	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXO98_016135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXO98_016145	COG0193	aminoacyl-tRNA hydrolase activity
IXO98_016150	COG0012	GTP binding
IXO98_016180	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXO98_016185	COG0250	Participates in transcription elongation, termination and antitermination
IXO98_016190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IXO98_016200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXO98_016205	COG0222	ribosome binding
IXO98_016210	COG0085	RNA polymerase activity
IXO98_016215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IXO98_016220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IXO98_016225	COG0049	tRNA binding
IXO98_016245	COG0051	transcription antitermination factor activity, RNA binding
IXO98_016250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXO98_016255	COG0088	Forms part of the polypeptide exit tunnel
IXO98_016260	COG0089	rRNA binding
IXO98_016275	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXO98_016285	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IXO98_016290	COG0255	Belongs to the universal ribosomal protein uL29 family
IXO98_016295	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXO98_016300	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IXO98_016310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXO98_016340	COG1841	ribosomal large subunit assembly
IXO98_016350	COG0201	protein transport
IXO98_016360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXO98_016365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IXO98_016375	COG0203	ribosomal protein L17
IXO98_016435	COG3551	Protein conserved in bacteria
IXO98_016465	COG2194	sulfuric ester hydrolase activity
IXO98_016475	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXO98_016480	COG0745	RESPONSE REGULATOR receiver
IXO98_016485	COG0642	Histidine kinase
IXO98_016495	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXO98_016500	COG2894	cell division
IXO98_016515	COG4585	Histidine kinase
IXO98_016520	COG2197	response regulator
IXO98_016535	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IXO98_016560	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IXO98_016565	COG2963	transposase activity
IXO98_016670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO98_016685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO98_016695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO98_016740	COG3328	transposase activity
IXO98_016755	COG3179	chitinase
IXO98_016870	COG3039	Transposase
IXO98_016885	COG3039	Transposase
IXO98_016945	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IXO98_016965	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXO98_016970	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO98_016975	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IXO98_016990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXO98_017025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO98_017030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO98_017065	COG0587	DNA-directed DNA polymerase activity
IXO98_017080	COG1297	OPT oligopeptide transporter protein
IXO98_017100	COG1506	peptidase
IXO98_017100	COG0823	Involved in the tonB-independent uptake of proteins
IXO98_017120	COG2207	Transcriptional regulator
IXO98_017120	COG1917	Cupin 2, conserved barrel domain protein
IXO98_017145	COG0753	catalase activity
IXO98_017175	COG0126	phosphoglycerate kinase activity
IXO98_017185	COG0469	pyruvate kinase activity
IXO98_017190	COG3588	fructose-bisphosphate aldolase
IXO98_017195	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IXO98_017240	COG0784	Response regulator, receiver
IXO98_017240	COG2198	Histidine kinase
IXO98_017240	COG2205	protein histidine kinase activity
IXO98_017260	COG0175	sulfate reduction
IXO98_017265	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXO98_017270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXO98_017275	COG0175	sulfate reduction
IXO98_017280	COG0529	Catalyzes the synthesis of activated sulfate
IXO98_017280	COG2895	sulfate adenylyltransferase (ATP) activity
IXO98_017290	COG3039	Transposase
IXO98_017300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO98_017305	COG0308	aminopeptidase N
IXO98_017325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXO98_017345	COG1970	mechanosensitive ion channel activity
IXO98_017375	COG0471	metal ion transport
IXO98_017375	COG3273	potassium ion transport
IXO98_017385	COG2022	thiamine diphosphate biosynthetic process
IXO98_017445	COG3039	Transposase
IXO98_017510	COG3118	belongs to the thioredoxin family
IXO98_017535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXO98_017560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXO98_017590	COG2968	Membrane
IXO98_017605	COG3164	Protein of unknown function
IXO98_017615	COG0312	modulator of DNA gyrase
IXO98_017620	COG3028	Belongs to the UPF0307 family
IXO98_017625	COG0312	modulator of DNA gyrase
IXO98_017650	COG0142	geranyltranstransferase activity
IXO98_017655	COG1722	exodeoxyribonuclease VII activity
IXO98_017660	COG0037	tRNA processing
IXO98_017665	COG1785	Belongs to the alkaline phosphatase family
IXO98_017670	COG1301	dicarboxylic acid transport
IXO98_017685	COG0791	NLP P60 protein
IXO98_017690	COG0791	NLP P60 protein
IXO98_017695	COG1047	Peptidyl-prolyl cis-trans
IXO98_017700	COG2311	Membrane
IXO98_017705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO98_017745	COG0489	protein tyrosine kinase activity
IXO98_017750	COG0717	Belongs to the dCTP deaminase family
IXO98_017770	COG0412	Dienelactone hydrolase
IXO98_017780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO98_017820	COG2890	protein-(glutamine-N5) methyltransferase activity
IXO98_017825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXO98_017830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXO98_017835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXO98_017855	COG0101	tRNA pseudouridine synthase activity
IXO98_017860	COG0135	phosphoribosylanthranilate isomerase activity
IXO98_017880	COG0159	tryptophan synthase activity
IXO98_017885	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXO98_017890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXO98_017915	COG3293	Transposase
IXO98_017940	COG0149	triose-phosphate isomerase activity
IXO98_017955	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO98_017965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IXO98_017970	COG0649	NAD binding
IXO98_017975	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IXO98_017980	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IXO98_017985	COG1034	ATP synthesis coupled electron transport
IXO98_017990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IXO98_018020	COG1007	ATP synthesis coupled electron transport
IXO98_018030	COG0779	Required for maturation of 30S ribosomal subunits
IXO98_018035	COG0195	Participates in both transcription termination and antitermination
IXO98_018040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IXO98_018055	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXO98_018060	COG1185	polyribonucleotide nucleotidyltransferase activity
IXO98_018095	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXO98_018105	COG2095	MarC family integral membrane protein
IXO98_018120	COG1611	Belongs to the LOG family
IXO98_018160	COG4969	Belongs to the N-Me-Phe pilin family
IXO98_018165	COG0556	nucleotide-excision repair
IXO98_018205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IXO98_018220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IXO98_018275	COG0438	transferase activity, transferring glycosyl groups
IXO98_018280	COG0438	transferase activity, transferring glycosyl groups
IXO98_018290	COG0438	transferase activity, transferring glycosyl groups
IXO98_018330	COG3040	lipid binding
IXO98_018410	COG3039	Transposase
IXO98_018415	COG0784	Response regulator, receiver
IXO98_018415	COG4191	Histidine kinase
IXO98_018435	COG0552	protein localization to endoplasmic reticulum
IXO98_018445	COG3938	Belongs to the proline racemase family
IXO98_018450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO98_018465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO98_018475	COG0006	proline dipeptidase activity
IXO98_018490	COG0531	amino acid
IXO98_018540	COG4206	TonB-dependent receptor
IXO98_018565	COG3328	transposase activity
IXO98_018625	COG0746	molybdenum cofactor guanylyltransferase activity
IXO98_018650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXO98_018650	COG1648	precorrin-2 dehydrogenase activity
IXO98_018690	COG3039	Transposase
IXO98_018705	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXO98_018725	COG1054	Belongs to the UPF0176 family
IXO98_018740	COG1530	ribonuclease E activity
IXO98_018750	COG3064	Membrane
IXO98_018755	COG0428	transporter
IXO98_018760	COG0428	transporter
IXO98_018770	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXO98_018820	COG3039	Transposase
IXO98_018940	COG0631	protein serine/threonine phosphatase activity
IXO98_018945	COG0515	serine threonine protein kinase
IXO98_018975	COG1858	cytochrome C peroxidase
IXO98_019025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO98_019030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO98_019095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXO98_019115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXO98_019130	COG1595	DNA-templated transcription, initiation
IXO98_019180	COG2244	polysaccharide biosynthetic process
IXO98_019210	COG2264	protein methyltransferase activity
IXO98_019220	COG0438	transferase activity, transferring glycosyl groups
IXO98_019235	COG1136	(ABC) transporter
IXO98_019240	COG1132	(ABC) transporter
IXO98_019250	COG0477	Major facilitator Superfamily
IXO98_019260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IXO98_019275	COG1253	flavin adenine dinucleotide binding
IXO98_019285	COG0306	phosphate transporter
IXO98_019315	COG0504	CTP synthase activity
IXO98_019320	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXO98_019330	COG0148	phosphopyruvate hydratase activity
IXO98_019335	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXO98_019340	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXO98_019350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXO98_019360	COG2840	Smr protein MutS2
IXO98_019365	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IXO98_019370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXO98_019375	COG1238	metal cluster binding
IXO98_019390	COG1534	Rna-binding protein
IXO98_019395	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IXO98_019405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXO98_019420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXO98_019425	COG1546	Belongs to the CinA family
IXO98_019440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXO98_019445	COG2137	regulation of response to DNA damage stimulus
IXO98_019450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXO98_019455	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IXO98_019480	COG0305	Participates in initiation and elongation during chromosome replication
IXO98_019485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXO98_019510	COG1741	Belongs to the pirin family
IXO98_019515	COG0583	DNA-binding transcription factor activity
IXO98_019545	COG0351	phosphomethylpyrimidine kinase
IXO98_019555	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXO98_019560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXO98_019580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXO98_019590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXO98_019595	COG3734	2-keto-3-deoxy-galactonokinase
IXO98_019605	COG4948	Mandelate Racemase Muconate Lactonizing
IXO98_019610	COG0800	Aldolase
IXO98_019625	COG1501	Belongs to the glycosyl hydrolase 31 family
IXO98_019635	COG1070	Carbohydrate kinase
IXO98_019645	COG0477	Major facilitator Superfamily
IXO98_019665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXO98_019715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXO98_019720	COG2258	MOSC domain
IXO98_019725	COG3293	Transposase
IXO98_019730	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IXO98_019735	COG0505	Belongs to the CarA family
IXO98_019745	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXO98_019750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXO98_019760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXO98_019825	COG2205	protein histidine kinase activity
IXO98_019825	COG0784	Response regulator, receiver
IXO98_019825	COG2198	Histidine kinase
IXO98_019830	COG1024	Enoyl-CoA hydratase
IXO98_019835	COG0318	PFAM AMP-dependent synthetase and ligase
IXO98_019865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IXO98_019895	COG0840	transmembrane signaling receptor activity
IXO98_019915	COG3039	Transposase
IXO98_019930	COG0835	chemotaxis
IXO98_019945	COG0840	transmembrane signaling receptor activity
IXO98_019950	COG0840	transmembrane signaling receptor activity
IXO98_019955	COG0840	transmembrane signaling receptor activity
IXO98_019960	COG0840	transmembrane signaling receptor activity
IXO98_019970	COG0840	transmembrane signaling receptor activity
IXO98_019980	COG0840	transmembrane signaling receptor activity
IXO98_019990	COG0840	transmembrane signaling receptor activity
IXO98_020010	COG0745	RESPONSE REGULATOR receiver
IXO98_020020	COG0835	chemotaxis
IXO98_020030	COG1360	Flagellar Motor Protein
IXO98_020035	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXO98_020055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO98_020065	COG4771	TonB-dependent receptor
IXO98_020240	COG3039	Transposase
IXO98_020255	COG3039	Transposase
IXO98_020265	COG3039	Transposase
IXO98_020280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO98_020280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXO98_020285	COG1105	Belongs to the carbohydrate kinase PfkB family
IXO98_020290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXO98_020290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXO98_020295	COG1609	Transcriptional regulator
IXO98_020320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXO98_020325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXO98_020335	COG2902	Dehydrogenase
IXO98_020340	COG3039	Transposase
IXO98_020350	COG2205	protein histidine kinase activity
IXO98_020350	COG0784	Response regulator, receiver
IXO98_020350	COG5002	protein histidine kinase activity
IXO98_020355	COG2733	membrane
IXO98_020365	COG1121	(ABC) transporter
IXO98_020370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXO98_020380	COG2223	nitrite transmembrane transporter activity
IXO98_020390	COG0243	molybdopterin cofactor binding
IXO98_020400	COG0477	Major facilitator Superfamily
IXO98_020410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXO98_020415	COG0174	glutamine synthetase
IXO98_020420	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IXO98_020450	COG3842	ATPase activity
IXO98_020460	COG1177	transmembrane transport
IXO98_020470	COG1012	belongs to the aldehyde dehydrogenase family
IXO98_020485	COG4535	Mg2 and Co2 transporter CorC
IXO98_020505	COG1702	phosphate starvation-inducible protein PhoH
IXO98_020530	COG0741	lytic transglycosylase activity
IXO98_020535	COG0723	plastoquinol--plastocyanin reductase activity
IXO98_020540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXO98_020545	COG2857	Cytochrome c1
IXO98_020550	COG0625	glutathione transferase activity
IXO98_020555	COG2969	positive regulation of protein catabolic process
IXO98_020590	COG3328	transposase activity
IXO98_020665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXO98_020685	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXO98_020690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXO98_020690	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXO98_020695	COG0802	atpase or kinase
IXO98_020700	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO98_020705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXO98_020725	COG1028	Short-chain dehydrogenase reductase Sdr
IXO98_020735	COG0501	Belongs to the peptidase M48B family
IXO98_020745	COG2081	HI0933 family
IXO98_020750	COG4681	YaeQ
IXO98_020755	COG1671	Belongs to the UPF0178 family
IXO98_020765	COG0625	glutathione transferase activity
IXO98_020775	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IXO98_020780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXO98_020785	COG0513	Belongs to the DEAD box helicase family
IXO98_020790	COG0488	(ABC) transporter
IXO98_020810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXO98_020815	COG0483	inositol monophosphate 1-phosphatase activity
IXO98_020830	COG5001	Diguanylate cyclase
IXO98_020830	COG3300	MHYT domain
IXO98_020835	COG1509	lysine 2,3-aminomutase activity
IXO98_020850	COG0402	S-adenosylhomocysteine deaminase activity
IXO98_020855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXO98_020880	COG4677	pectinesterase activity
IXO98_020905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXO98_020930	COG2166	iron-sulfur cluster assembly
IXO98_020945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXO98_020950	COG0137	argininosuccinate synthase activity
IXO98_020960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXO98_020965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXO98_020980	COG0165	Argininosuccinate lyase
IXO98_021000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXO98_021035	COG3039	Transposase
IXO98_021050	COG4988	ABC transporter
IXO98_021055	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXO98_021065	COG3039	Transposase
IXO98_021180	COG3209	COG3209 Rhs family protein
IXO98_021190	COG3039	Transposase
IXO98_021225	COG2198	Histidine kinase
IXO98_021225	COG0643	Histidine kinase
IXO98_021225	COG0784	Response regulator, receiver
IXO98_021280	COG1684	flagellar biosynthetic protein fliR
IXO98_021295	COG3190	flagellar
IXO98_021345	COG1677	Flagellar hook-basal body complex protein FliE
IXO98_021375	COG1028	Short-chain dehydrogenase reductase Sdr
IXO98_021385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXO98_021405	COG2201	protein-glutamate methylesterase activity
IXO98_021435	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXO98_021440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXO98_021475	COG4787	bacterial-type flagellum-dependent cell motility
IXO98_021485	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IXO98_021490	COG1558	bacterial-type flagellum-dependent cell motility
IXO98_021500	COG0784	Response regulator, receiver
IXO98_021500	COG0835	chemotaxis
IXO98_021520	COG5002	protein histidine kinase activity
IXO98_021530	COG4585	Histidine kinase
IXO98_021535	COG5001	Diguanylate cyclase
IXO98_021560	COG0482	sulfurtransferase activity
IXO98_021575	COG0542	response to heat
IXO98_021600	COG0492	ferredoxin-NADP+ reductase activity
IXO98_021605	COG1674	ftsk spoiiie
IXO98_021625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXO98_021645	COG0038	chloride channel
IXO98_021650	COG0183	Belongs to the thiolase family
IXO98_021655	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXO98_021655	COG1024	Enoyl-CoA hydratase
IXO98_021670	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IXO98_021680	COG1426	Protein conserved in bacteria
IXO98_021690	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXO98_021700	COG0303	'Molybdopterin
IXO98_021755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXO98_021805	COG0742	ribosomal rna small subunit methyltransferase
IXO98_021810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXO98_021825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXO98_021830	COG0405	Gamma-glutamyltransferase
IXO98_021855	COG3039	Transposase
IXO98_021940	COG0343	queuine tRNA-ribosyltransferase activity
IXO98_021945	COG1862	Preprotein translocase
IXO98_021950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO98_021955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXO98_021995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IXO98_022005	COG0704	Plays a role in the regulation of phosphate uptake
IXO98_022020	COG0573	inorganic phosphate transmembrane transporter activity
IXO98_022025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXO98_022070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXO98_022080	COG1024	Enoyl-CoA hydratase
IXO98_022095	COG0494	nUDIX hydrolase
IXO98_022140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXO98_022140	COG0116	Belongs to the methyltransferase superfamily
IXO98_022165	COG0667	Aldo Keto reductase
IXO98_022175	COG2925	Exonuclease
IXO98_022210	COG0288	reversible hydration of carbon dioxide
IXO98_022240	COG0316	Belongs to the HesB IscA family
IXO98_022245	COG0360	Binds together with S18 to 16S ribosomal RNA
IXO98_022255	COG0359	binds to the 23S rRNA
IXO98_022265	COG3115	cell septum assembly
IXO98_022285	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXO98_022305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IXO98_022330	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXO98_022340	COG2986	histidine ammonia-lyase
IXO98_022345	COG1228	amidohydrolase
IXO98_022385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IXO98_022395	COG1605	Chorismate mutase
IXO98_022395	COG0077	Prephenate dehydratase
IXO98_022400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXO98_022435	COG4566	intracellular signal transduction
IXO98_022480	COG0860	N-Acetylmuramoyl-L-alanine amidase
IXO98_022485	COG1469	GTP cyclohydrolase I activity
IXO98_022495	COG0617	tRNA 3'-terminal CCA addition
IXO98_022505	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IXO98_022510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IXO98_022540	COG1472	Belongs to the glycosyl hydrolase 3 family
IXO98_022555	COG5001	Diguanylate cyclase
IXO98_022555	COG4251	negative regulation of phosphorylation
IXO98_022555	COG3706	GGDEF domain
IXO98_022555	COG2203	Gaf domain
IXO98_022615	COG1595	DNA-templated transcription, initiation
IXO98_022640	COG0386	Belongs to the glutathione peroxidase family
IXO98_022715	COG3039	Transposase
IXO98_022730	COG2205	protein histidine kinase activity
IXO98_022730	COG0784	Response regulator, receiver
IXO98_022730	COG5002	protein histidine kinase activity
IXO98_022770	COG0800	Aldolase
IXO98_022775	COG0129	dihydroxy-acid dehydratase activity
IXO98_022780	COG0363	glucosamine-6-phosphate deaminase activity
IXO98_022790	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IXO98_022805	COG0354	folic acid binding
IXO98_022820	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXO98_022835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXO98_022850	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXO98_022875	COG0811	peptide transport
IXO98_022890	COG1663	tetraacyldisaccharide 4'-kinase activity
IXO98_022900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXO98_022910	COG0322	excinuclease ABC activity
IXO98_022945	COG3328	transposase activity
IXO98_022965	COG3039	Transposase