locus-tag	class	description
O5966_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O5966_00020	COG0187	DNA topoisomerase II activity
O5966_00030	COG0501	Belongs to the peptidase M48B family
O5966_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
O5966_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O5966_00080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
O5966_00090	COG4772	TonB-dependent receptor
O5966_00105	COG3039	Transposase
O5966_00110	COG1304	FMN binding
O5966_00130	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O5966_00145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O5966_00215	COG3039	Transposase
O5966_00235	COG2826	transposase and inactivated derivatives, IS30 family
O5966_00270	COG1090	epimerase
O5966_00290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O5966_00400	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O5966_00475	COG1511	domain protein
O5966_00475	COG3264	Mechanosensitive ion channel
O5966_00490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O5966_00495	COG2354	Protein conserved in bacteria
O5966_00500	COG1649	PFAM Uncharacterised BCR, COG1649
O5966_00520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O5966_00545	COG0702	epimerase
O5966_00560	COG1858	cytochrome C peroxidase
O5966_00635	COG0513	Belongs to the DEAD box helicase family
O5966_00685	COG1136	(ABC) transporter
O5966_00720	COG1136	(ABC) transporter
O5966_00760	COG1272	protein, Hemolysin III
O5966_00765	COG1111	helicase
O5966_00765	COG1205	dead DEAH box helicase
O5966_00825	COG0067	glutamate synthase
O5966_00825	COG0069	glutamate synthase activity
O5966_00825	COG0070	glutamate synthase
O5966_00830	COG0493	'glutamate synthase
O5966_00875	COG1609	Transcriptional regulator
O5966_00900	COG0366	Alpha amylase catalytic
O5966_00905	COG0366	Alpha amylase catalytic
O5966_00950	COG0606	chelatase, subunit chli
O5966_00990	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
O5966_00995	COG1166	arginine decarboxylase activity
O5966_01055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O5966_01080	COG1028	Short-chain dehydrogenase reductase Sdr
O5966_01105	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
O5966_01125	COG0210	DNA helicase
O5966_01140	COG3132	Protein of unknown function, DUF480
O5966_01145	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
O5966_01150	COG0284	orotidine-5'-phosphate decarboxylase activity
O5966_01185	COG2937	Belongs to the GPAT DAPAT family
O5966_01225	COG3186	Phenylalanine-4-hydroxylase
O5966_01230	COG1522	sequence-specific DNA binding
O5966_01275	COG1064	alcohol dehydrogenase
O5966_01280	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
O5966_01290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
O5966_01300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
O5966_01320	COG0676	glucose-6-phosphate 1-epimerase activity
O5966_01385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O5966_01410	COG2853	Lipoprotein
O5966_01425	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O5966_01430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O5966_01435	COG1127	ABC transporter
O5966_01510	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O5966_01515	COG3293	Transposase
O5966_01520	COG3039	Transposase
O5966_01525	COG3265	gluconokinase activity
O5966_01530	COG2211	Major facilitator Superfamily
O5966_01535	COG3459	Glycosyltransferase 36 associated
O5966_01545	COG2205	protein histidine kinase activity
O5966_01560	COG1414	Transcriptional regulator
O5966_01565	COG0738	Major facilitator superfamily
O5966_01570	COG3254	rhamnose metabolic process
O5966_01600	COG0339	signal peptide processing
O5966_01630	COG0564	pseudouridine synthase activity
O5966_01640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O5966_01650	COG1181	Belongs to the D-alanine--D-alanine ligase family
O5966_01715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O5966_01725	COG0842	Transport permease protein
O5966_01730	COG1131	(ABC) transporter
O5966_01760	COG1476	TRANSCRIPTIONal
O5966_01770	COG4555	ABC transporter
O5966_01805	COG0625	glutathione transferase activity
O5966_01850	COG0583	DNA-binding transcription factor activity
O5966_01890	COG1199	ATP-dependent helicase activity
O5966_01930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O5966_01960	COG3228	Belongs to the MtfA family
O5966_01970	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
O5966_01970	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
O5966_01975	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
O5966_01990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O5966_02025	COG3237	CsbD-like
O5966_02030	COG0180	Tryptophanyl-tRNA synthetase
O5966_02035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O5966_02080	COG0753	catalase activity
O5966_02095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O5966_02105	COG0628	permease
O5966_02115	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
O5966_02120	COG1040	competence protein
O5966_02125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O5966_02130	COG0156	8-amino-7-oxononanoate synthase activity
O5966_02140	COG1028	Short-chain dehydrogenase reductase Sdr
O5966_02155	COG0463	Glycosyl transferase, family 2
O5966_02165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O5966_02170	COG3100	YcgL domain-containing protein
O5966_02185	COG3387	PFAM Glycoside hydrolase 15-related
O5966_02190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
O5966_02205	COG2239	Acts as a magnesium transporter
O5966_02215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O5966_02215	COG1042	CoA-binding domain protein
O5966_02215	COG0045	succinate-CoA ligase (ADP-forming) activity
O5966_02225	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O5966_02230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O5966_02265	COG3485	protocatechuate 3,4-dioxygenase
O5966_02285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O5966_02290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O5966_02315	COG4221	oxidoreductase activity
O5966_02340	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O5966_02365	COG0463	Glycosyl transferase, family 2
O5966_02380	COG1475	DNA binding
O5966_02385	COG1192	Involved in chromosome partitioning
O5966_02400	COG0708	Exodeoxyribonuclease III
O5966_02405	COG2211	Major facilitator Superfamily
O5966_02420	COG0739	heme binding
O5966_02465	COG0745	RESPONSE REGULATOR receiver
O5966_02500	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
O5966_02515	COG2814	Major facilitator Superfamily
O5966_02530	COG1289	transmembrane transporter activity
O5966_02550	COG0577	efflux transmembrane transporter activity
O5966_02550	COG1136	(ABC) transporter
O5966_02555	COG0151	Belongs to the GarS family
O5966_02565	COG0138	bifunctional purine biosynthesis protein purh
O5966_02595	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
O5966_02635	COG0439	Biotin carboxylase
O5966_02645	COG0511	ligase activity, forming carbon-carbon bonds
O5966_02650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O5966_02660	COG1324	tolerance protein
O5966_02695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O5966_02715	COG0534	Mate efflux family protein
O5966_02720	COG0616	signal peptide processing
O5966_02730	COG1028	Short-chain dehydrogenase reductase Sdr
O5966_02745	COG0009	L-threonylcarbamoyladenylate synthase
O5966_02750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O5966_02750	COG1754	DNA topoisomerase type I activity
O5966_02765	COG2922	Belongs to the Smg family
O5966_02770	COG0758	DNA mediated transformation
O5966_02775	COG1652	LysM domain
O5966_02780	COG0242	peptide deformylase activity
O5966_02785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O5966_02850	COG1560	Kdo2-lipid A biosynthetic process
O5966_02860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O5966_03010	COG3039	Transposase
O5966_03020	COG1271	oxidase subunit
O5966_03085	COG0531	amino acid
O5966_03105	COG3590	peptidase
O5966_03115	COG0667	Aldo Keto reductase
O5966_03130	COG3384	dioxygenase
O5966_03140	COG1573	uracil-dna glycosylase
O5966_03150	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
O5966_03160	COG0025	NhaP-type Na H and K H
O5966_03165	COG1131	(ABC) transporter
O5966_03170	COG0842	Transport permease protein
O5966_03185	COG1404	Belongs to the peptidase S8 family
O5966_03200	COG0745	RESPONSE REGULATOR receiver
O5966_03250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O5966_03275	COG2205	protein histidine kinase activity
O5966_03275	COG2202	Pas domain
O5966_03305	COG2813	Specifically methylates the guanine in position
O5966_03310	COG1187	pseudouridine synthase activity
O5966_03315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O5966_03350	COG0697	spore germination
O5966_03360	COG2011	ABC-type metal ion transport system permease component
O5966_03390	COG0508	dehydrogenase complex catalyzes the overall conversion of
O5966_03400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O5966_03420	COG0356	it plays a direct role in the translocation of protons across the membrane
O5966_03430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O5966_03440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O5966_03445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O5966_03450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O5966_03455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O5966_03505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O5966_03510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O5966_03560	COG0339	signal peptide processing
O5966_03595	COG1956	GAF domain-containing protein
O5966_03600	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
O5966_03610	COG0720	synthase
O5966_03615	COG0513	Belongs to the DEAD box helicase family
O5966_03625	COG0625	glutathione transferase activity
O5966_03655	COG0626	cystathionine gamma-synthase activity
O5966_03695	COG3328	transposase activity
O5966_03720	COG2086	electron transfer activity
O5966_03745	COG0662	Cupin 2, conserved barrel domain protein
O5966_03745	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
O5966_03750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O5966_03785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O5966_03785	COG3218	ABC-type transport auxiliary lipoprotein component
O5966_03790	COG1127	ABC transporter
O5966_03795	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O5966_03815	COG0442	prolyl-tRNA aminoacylation
O5966_03825	COG1183	phosphatidylcholine synthase activity
O5966_03890	COG3039	Transposase
O5966_03920	COG0525	valine-tRNA ligase activity
O5966_03935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O5966_03945	COG0795	lipopolysaccharide-transporting ATPase activity
O5966_03960	COG4974	Belongs to the 'phage' integrase family
O5966_03965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O5966_03970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O5966_03970	COG0047	phosphoribosylformylglycinamidine synthase activity
O5966_03975	COG5295	Hep Hag repeat protein
O5966_03985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O5966_03995	COG1459	type II secretion system
O5966_04000	COG2165	general secretion pathway protein
O5966_04005	COG4970	Tfp pilus assembly protein FimT
O5966_04010	COG2165	general secretion pathway protein
O5966_04015	COG4795	General secretion pathway protein
O5966_04020	COG3156	type II secretion system protein K
O5966_04025	COG3166	PFAM Fimbrial assembly family protein
O5966_04040	COG1450	Type ii and iii secretion system protein
O5966_04055	COG2188	Transcriptional regulator
O5966_04100	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
O5966_04105	COG1518	maintenance of DNA repeat elements
O5966_04150	COG3039	Transposase
O5966_04165	COG1399	metal-binding, possibly nucleic acid-binding protein
O5966_04190	COG1028	Short-chain dehydrogenase reductase Sdr
O5966_04195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O5966_04205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O5966_04210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O5966_04230	COG3039	Transposase
O5966_04250	COG3829	transcription factor binding
O5966_04330	COG2826	transposase and inactivated derivatives, IS30 family
O5966_04340	COG0678	peroxiredoxin activity
O5966_04360	COG0330	HflC and HflK could
O5966_04365	COG0330	HflC and HflK could
O5966_04375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
O5966_04380	COG0308	aminopeptidase N
O5966_04440	COG1560	Kdo2-lipid A biosynthetic process
O5966_04445	COG1519	Transferase
O5966_04450	COG1538	Outer membrane efflux protein
O5966_04455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
O5966_04485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O5966_04490	COG0066	3-isopropylmalate dehydratase activity
O5966_04495	COG2226	methyltransferase
O5966_04525	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O5966_04535	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
O5966_04540	COG3710	Transcriptional regulator
O5966_04565	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
O5966_04585	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
O5966_04620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O5966_04630	COG3781	membrane
O5966_04765	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
O5966_04785	COG1217	gtp-binding protein TYPA
O5966_04790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O5966_04795	COG0039	L-malate dehydrogenase activity
O5966_04800	COG0625	glutathione transferase activity
O5966_04815	COG3039	Transposase
O5966_04850	COG0584	glycerophosphoryl diester phosphodiesterase
O5966_04885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O5966_04915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O5966_04920	COG0583	DNA-binding transcription factor activity
O5966_04925	COG3634	alkyl hydroperoxide reductase activity
O5966_04935	COG2890	protein-(glutamine-N5) methyltransferase activity
O5966_04975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O5966_04975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O5966_04990	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
O5966_05015	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
O5966_05040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O5966_05050	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
O5966_05080	COG1295	ribonuclease BN
O5966_05085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O5966_05105	COG0521	Mo-molybdopterin cofactor biosynthetic process
O5966_05115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O5966_05120	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O5966_05130	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
O5966_05145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O5966_05155	COG0193	aminoacyl-tRNA hydrolase activity
O5966_05160	COG0012	GTP binding
O5966_05190	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O5966_05195	COG0250	Participates in transcription elongation, termination and antitermination
O5966_05200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O5966_05210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O5966_05215	COG0222	ribosome binding
O5966_05220	COG0085	RNA polymerase activity
O5966_05225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O5966_05230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O5966_05235	COG0049	tRNA binding
O5966_05255	COG0051	transcription antitermination factor activity, RNA binding
O5966_05260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O5966_05265	COG0088	Forms part of the polypeptide exit tunnel
O5966_05270	COG0089	rRNA binding
O5966_05285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
O5966_05295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O5966_05300	COG0255	Belongs to the universal ribosomal protein uL29 family
O5966_05305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O5966_05310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O5966_05320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O5966_05350	COG1841	ribosomal large subunit assembly
O5966_05360	COG0201	protein transport
O5966_05370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O5966_05375	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O5966_05385	COG0203	ribosomal protein L17
O5966_05445	COG3551	Protein conserved in bacteria
O5966_05475	COG2194	sulfuric ester hydrolase activity
O5966_05485	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O5966_05490	COG0745	RESPONSE REGULATOR receiver
O5966_05495	COG0642	Histidine kinase
O5966_05505	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
O5966_05510	COG2894	cell division
O5966_05525	COG4585	Histidine kinase
O5966_05530	COG2197	response regulator
O5966_05545	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
O5966_05570	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
O5966_05705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O5966_05720	COG3039	Transposase
O5966_05725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O5966_05785	COG3179	chitinase
O5966_05905	COG3039	Transposase
O5966_05925	COG3039	Transposase
O5966_05985	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
O5966_06005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
O5966_06010	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
O5966_06015	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
O5966_06030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
O5966_06105	COG0587	DNA-directed DNA polymerase activity
O5966_06120	COG1297	OPT oligopeptide transporter protein
O5966_06140	COG1506	peptidase
O5966_06140	COG0823	Involved in the tonB-independent uptake of proteins
O5966_06160	COG2207	Transcriptional regulator
O5966_06160	COG1917	Cupin 2, conserved barrel domain protein
O5966_06185	COG0753	catalase activity
O5966_06225	COG0469	pyruvate kinase activity
O5966_06230	COG3588	fructose-bisphosphate aldolase
O5966_06235	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
O5966_06285	COG2198	Histidine kinase
O5966_06285	COG2205	protein histidine kinase activity
O5966_06285	COG0784	Response regulator, receiver
O5966_06305	COG0175	sulfate reduction
O5966_06310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O5966_06315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O5966_06320	COG0175	sulfate reduction
O5966_06325	COG0529	Catalyzes the synthesis of activated sulfate
O5966_06325	COG2895	sulfate adenylyltransferase (ATP) activity
O5966_06335	COG3039	Transposase
O5966_06345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O5966_06350	COG0308	aminopeptidase N
O5966_06370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O5966_06390	COG1970	mechanosensitive ion channel activity
O5966_06420	COG0471	metal ion transport
O5966_06420	COG3273	potassium ion transport
O5966_06430	COG2022	thiamine diphosphate biosynthetic process
O5966_06550	COG3118	belongs to the thioredoxin family
O5966_06575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O5966_06595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
O5966_06625	COG2968	Membrane
O5966_06640	COG3164	Protein of unknown function
O5966_06650	COG0312	modulator of DNA gyrase
O5966_06655	COG3028	Belongs to the UPF0307 family
O5966_06660	COG0312	modulator of DNA gyrase
O5966_06685	COG0142	geranyltranstransferase activity
O5966_06690	COG1722	exodeoxyribonuclease VII activity
O5966_06695	COG0037	tRNA processing
O5966_06700	COG1785	Belongs to the alkaline phosphatase family
O5966_06720	COG0791	NLP P60 protein
O5966_06725	COG0791	NLP P60 protein
O5966_06730	COG1047	Peptidyl-prolyl cis-trans
O5966_06735	COG2311	Membrane
O5966_06740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O5966_06780	COG0489	protein tyrosine kinase activity
O5966_06785	COG0717	Belongs to the dCTP deaminase family
O5966_06815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O5966_06855	COG2890	protein-(glutamine-N5) methyltransferase activity
O5966_06860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O5966_06865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O5966_06870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O5966_06890	COG0101	tRNA pseudouridine synthase activity
O5966_06895	COG0135	phosphoribosylanthranilate isomerase activity
O5966_06915	COG0159	tryptophan synthase activity
O5966_06920	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O5966_06925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O5966_06975	COG0149	triose-phosphate isomerase activity
O5966_06990	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O5966_07000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O5966_07005	COG0649	NAD binding
O5966_07010	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
O5966_07015	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
O5966_07020	COG1034	ATP synthesis coupled electron transport
O5966_07025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
O5966_07055	COG1007	ATP synthesis coupled electron transport
O5966_07065	COG0779	Required for maturation of 30S ribosomal subunits
O5966_07070	COG0195	Participates in both transcription termination and antitermination
O5966_07075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O5966_07090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O5966_07095	COG1185	polyribonucleotide nucleotidyltransferase activity
O5966_07130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
O5966_07140	COG2095	MarC family integral membrane protein
O5966_07155	COG1611	Belongs to the LOG family
O5966_07195	COG4969	Belongs to the N-Me-Phe pilin family
O5966_07200	COG0556	nucleotide-excision repair
O5966_07240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O5966_07255	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O5966_07310	COG0438	transferase activity, transferring glycosyl groups
O5966_07315	COG0438	transferase activity, transferring glycosyl groups
O5966_07325	COG0438	transferase activity, transferring glycosyl groups
O5966_07365	COG3040	lipid binding
O5966_07440	COG0784	Response regulator, receiver
O5966_07440	COG4191	Histidine kinase
O5966_07460	COG0552	protein localization to endoplasmic reticulum
O5966_07470	COG3938	Belongs to the proline racemase family
O5966_07475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O5966_07490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O5966_07500	COG0006	proline dipeptidase activity
O5966_07515	COG0531	amino acid
O5966_07545	COG4206	TonB-dependent receptor
O5966_07570	COG3328	transposase activity
O5966_07630	COG0746	molybdenum cofactor guanylyltransferase activity
O5966_07655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O5966_07655	COG1648	precorrin-2 dehydrogenase activity
O5966_07695	COG3039	Transposase
O5966_07725	COG3039	Transposase
O5966_07740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
O5966_07760	COG1054	Belongs to the UPF0176 family
O5966_07770	COG3293	Transposase
O5966_07775	COG1530	ribonuclease E activity
O5966_07785	COG3064	Membrane
O5966_07800	COG2154	pterin-4-alpha-carbinolamine dehydratase
O5966_07805	COG0316	Belongs to the HesB IscA family
O5966_07805	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
O5966_07975	COG0631	protein serine/threonine phosphatase activity
O5966_08010	COG1858	cytochrome C peroxidase
O5966_08070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O5966_08075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O5966_08095	COG2201	protein-glutamate methylesterase activity
O5966_08140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O5966_08160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O5966_08175	COG1595	DNA-templated transcription, initiation
O5966_08225	COG2244	polysaccharide biosynthetic process
O5966_08255	COG2264	protein methyltransferase activity
O5966_08265	COG0438	transferase activity, transferring glycosyl groups
O5966_08280	COG1136	(ABC) transporter
O5966_08285	COG1132	(ABC) transporter
O5966_08295	COG0477	Major facilitator Superfamily
O5966_08305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5966_08320	COG1253	flavin adenine dinucleotide binding
O5966_08330	COG0306	phosphate transporter
O5966_08360	COG0504	CTP synthase activity
O5966_08365	COG2877	3-deoxy-8-phosphooctulonate synthase activity
O5966_08375	COG0148	phosphopyruvate hydratase activity
O5966_08380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
O5966_08385	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O5966_08395	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O5966_08405	COG2840	Smr protein MutS2
O5966_08410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
O5966_08415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
O5966_08420	COG1238	metal cluster binding
O5966_08435	COG1534	Rna-binding protein
O5966_08440	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
O5966_08450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O5966_08455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O5966_08465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O5966_08470	COG1546	Belongs to the CinA family
O5966_08485	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O5966_08490	COG2137	regulation of response to DNA damage stimulus
O5966_08495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O5966_08500	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
O5966_08525	COG0305	Participates in initiation and elongation during chromosome replication
O5966_08530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O5966_08555	COG1741	Belongs to the pirin family
O5966_08560	COG0583	DNA-binding transcription factor activity
O5966_08585	COG0351	phosphomethylpyrimidine kinase
O5966_08595	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O5966_08600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O5966_08620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O5966_08630	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
O5966_08635	COG3734	2-keto-3-deoxy-galactonokinase
O5966_08645	COG4948	Mandelate Racemase Muconate Lactonizing
O5966_08650	COG0800	Aldolase
O5966_08665	COG1501	Belongs to the glycosyl hydrolase 31 family
O5966_08675	COG1070	Carbohydrate kinase
O5966_08685	COG0477	Major facilitator Superfamily
O5966_08705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O5966_08750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O5966_08755	COG2258	MOSC domain
O5966_08765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O5966_08770	COG0505	Belongs to the CarA family
O5966_08780	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O5966_08785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O5966_08795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
O5966_08855	COG2205	protein histidine kinase activity
O5966_08855	COG2198	Histidine kinase
O5966_08855	COG0784	Response regulator, receiver
O5966_08860	COG1024	Enoyl-CoA hydratase
O5966_08865	COG0318	PFAM AMP-dependent synthetase and ligase
O5966_08895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O5966_08925	COG0840	transmembrane signaling receptor activity
O5966_08945	COG3039	Transposase
O5966_08960	COG0835	chemotaxis
O5966_08975	COG0840	transmembrane signaling receptor activity
O5966_08980	COG0840	transmembrane signaling receptor activity
O5966_08990	COG0840	transmembrane signaling receptor activity
O5966_09000	COG0840	transmembrane signaling receptor activity
O5966_09010	COG0840	transmembrane signaling receptor activity
O5966_09040	COG0745	RESPONSE REGULATOR receiver
O5966_09050	COG0835	chemotaxis
O5966_09065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O5966_09085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O5966_09095	COG4771	TonB-dependent receptor
O5966_09135	COG3039	Transposase
O5966_09205	COG3409	Peptidoglycan-binding domain 1 protein
O5966_09205	COG3501	Rhs element vgr protein
O5966_09225	COG3501	Rhs element vgr protein
O5966_09225	COG3409	Peptidoglycan-binding domain 1 protein
O5966_09325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O5966_09325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O5966_09330	COG1105	Belongs to the carbohydrate kinase PfkB family
O5966_09335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O5966_09335	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O5966_09340	COG1609	Transcriptional regulator
O5966_09365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O5966_09370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O5966_09380	COG2902	Dehydrogenase
O5966_09385	COG3039	Transposase
O5966_09395	COG0784	Response regulator, receiver
O5966_09395	COG5002	protein histidine kinase activity
O5966_09395	COG2205	protein histidine kinase activity
O5966_09400	COG2733	membrane
O5966_09410	COG1121	(ABC) transporter
O5966_09415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O5966_09420	COG2223	nitrite transmembrane transporter activity
O5966_09430	COG0243	molybdopterin cofactor binding
O5966_09440	COG0477	Major facilitator Superfamily
O5966_09450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O5966_09455	COG0174	glutamine synthetase
O5966_09490	COG3842	ATPase activity
O5966_09520	COG1012	belongs to the aldehyde dehydrogenase family
O5966_09535	COG4535	Mg2 and Co2 transporter CorC
O5966_09555	COG1702	phosphate starvation-inducible protein PhoH
O5966_09580	COG0741	lytic transglycosylase activity
O5966_09585	COG0723	plastoquinol--plastocyanin reductase activity
O5966_09590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O5966_09595	COG2857	Cytochrome c1
O5966_09600	COG0625	glutathione transferase activity
O5966_09605	COG2969	positive regulation of protein catabolic process
O5966_09630	COG2094	Belongs to the DNA glycosylase MPG family
O5966_09640	COG3328	transposase activity
O5966_09715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O5966_09735	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
O5966_09740	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
O5966_09740	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
O5966_09745	COG0802	atpase or kinase
O5966_09750	COG0860	N-Acetylmuramoyl-L-alanine amidase
O5966_09755	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O5966_09775	COG1028	Short-chain dehydrogenase reductase Sdr
O5966_09785	COG0501	Belongs to the peptidase M48B family
O5966_09795	COG2081	HI0933 family
O5966_09800	COG4681	YaeQ
O5966_09805	COG1671	Belongs to the UPF0178 family
O5966_09815	COG0625	glutathione transferase activity
O5966_09825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
O5966_09830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O5966_09835	COG0513	Belongs to the DEAD box helicase family
O5966_09840	COG0488	(ABC) transporter
O5966_09860	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O5966_09865	COG0483	inositol monophosphate 1-phosphatase activity
O5966_09880	COG3300	MHYT domain
O5966_09880	COG5001	Diguanylate cyclase
O5966_09885	COG1509	lysine 2,3-aminomutase activity
O5966_09900	COG0402	S-adenosylhomocysteine deaminase activity
O5966_09905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O5966_09930	COG4677	pectinesterase activity
O5966_09955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O5966_09985	COG2166	iron-sulfur cluster assembly
O5966_10000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O5966_10005	COG0137	argininosuccinate synthase activity
O5966_10015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O5966_10020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O5966_10035	COG0165	Argininosuccinate lyase
O5966_10055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O5966_10090	COG3039	Transposase
O5966_10105	COG4988	ABC transporter
O5966_10110	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O5966_10120	COG3039	Transposase
O5966_10240	COG3209	COG3209 Rhs family protein
O5966_10250	COG3039	Transposase
O5966_10285	COG2198	Histidine kinase
O5966_10285	COG0643	Histidine kinase
O5966_10285	COG0784	Response regulator, receiver
O5966_10340	COG1684	flagellar biosynthetic protein fliR
O5966_10355	COG3190	flagellar
O5966_10405	COG1677	Flagellar hook-basal body complex protein FliE
O5966_10435	COG1028	Short-chain dehydrogenase reductase Sdr
O5966_10445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O5966_10465	COG2201	protein-glutamate methylesterase activity
O5966_10500	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
O5966_10505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O5966_10540	COG4787	bacterial-type flagellum-dependent cell motility
O5966_10550	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
O5966_10555	COG1558	bacterial-type flagellum-dependent cell motility
O5966_10565	COG0835	chemotaxis
O5966_10565	COG0784	Response regulator, receiver
O5966_10585	COG5002	protein histidine kinase activity
O5966_10595	COG4585	Histidine kinase
O5966_10600	COG5001	Diguanylate cyclase
O5966_10625	COG0482	sulfurtransferase activity
O5966_10640	COG0542	response to heat
O5966_10675	COG0492	ferredoxin-NADP+ reductase activity
O5966_10680	COG1674	ftsk spoiiie
O5966_10700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O5966_10720	COG0038	chloride channel
O5966_10725	COG0183	Belongs to the thiolase family
O5966_10730	COG1250	3-hydroxyacyl-CoA dehydrogenase
O5966_10730	COG1024	Enoyl-CoA hydratase
O5966_10745	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O5966_10755	COG1426	Protein conserved in bacteria
O5966_10765	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O5966_10775	COG0303	'Molybdopterin
O5966_10830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O5966_10880	COG0742	ribosomal rna small subunit methyltransferase
O5966_10885	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O5966_10900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
O5966_10905	COG0405	Gamma-glutamyltransferase
O5966_11005	COG0343	queuine tRNA-ribosyltransferase activity
O5966_11010	COG1862	Preprotein translocase
O5966_11015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O5966_11020	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O5966_11030	COG3039	Transposase
O5966_11060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O5966_11070	COG0704	Plays a role in the regulation of phosphate uptake
O5966_11085	COG0573	inorganic phosphate transmembrane transporter activity
O5966_11090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
O5966_11140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O5966_11150	COG1024	Enoyl-CoA hydratase
O5966_11165	COG0494	nUDIX hydrolase
O5966_11210	COG0116	Belongs to the methyltransferase superfamily
O5966_11210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O5966_11235	COG0667	Aldo Keto reductase
O5966_11245	COG2925	Exonuclease
O5966_11270	COG0288	reversible hydration of carbon dioxide
O5966_11300	COG0316	Belongs to the HesB IscA family
O5966_11305	COG0360	Binds together with S18 to 16S ribosomal RNA
O5966_11315	COG0359	binds to the 23S rRNA
O5966_11325	COG3115	cell septum assembly
O5966_11345	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
O5966_11365	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
O5966_11390	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
O5966_11400	COG2986	histidine ammonia-lyase
O5966_11405	COG1228	amidohydrolase
O5966_11445	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O5966_11455	COG0077	Prephenate dehydratase
O5966_11455	COG1605	Chorismate mutase
O5966_11460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O5966_11490	COG4566	intracellular signal transduction
O5966_11535	COG0860	N-Acetylmuramoyl-L-alanine amidase
O5966_11540	COG1469	GTP cyclohydrolase I activity
O5966_11550	COG0617	tRNA 3'-terminal CCA addition
O5966_11560	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O5966_11565	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O5966_11595	COG1472	Belongs to the glycosyl hydrolase 3 family
O5966_11610	COG5001	Diguanylate cyclase
O5966_11610	COG4251	negative regulation of phosphorylation
O5966_11610	COG2203	Gaf domain
O5966_11610	COG3706	GGDEF domain
O5966_11670	COG1595	DNA-templated transcription, initiation
O5966_11695	COG0386	Belongs to the glutathione peroxidase family
O5966_11770	COG3039	Transposase
O5966_11785	COG0784	Response regulator, receiver
O5966_11785	COG2205	protein histidine kinase activity
O5966_11785	COG5002	protein histidine kinase activity
O5966_11825	COG0800	Aldolase
O5966_11830	COG0129	dihydroxy-acid dehydratase activity
O5966_11835	COG0363	glucosamine-6-phosphate deaminase activity
O5966_11845	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
O5966_11860	COG0354	folic acid binding
O5966_11875	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
O5966_11890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O5966_11905	COG4591	ABC-type transport system involved in lipoprotein release permease component
O5966_11930	COG0811	peptide transport
O5966_11945	COG1663	tetraacyldisaccharide 4'-kinase activity
O5966_11955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O5966_11965	COG0322	excinuclease ABC activity
O5966_12020	COG3039	Transposase
O5966_12040	COG2201	protein-glutamate methylesterase activity
O5966_12305	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O5966_12305	COG0140	phosphoribosyl-ATP diphosphatase activity
O5966_12315	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O5966_12325	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
O5966_12325	COG0131	Imidazoleglycerol-phosphate dehydratase
O5966_12340	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O5966_12360	COG0124	histidyl-tRNA synthetase
O5966_12375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O5966_12410	COG1012	belongs to the aldehyde dehydrogenase family
O5966_12425	COG0167	dihydroorotate dehydrogenase activity
O5966_12430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O5966_12435	COG0697	spore germination
O5966_12460	COG0671	phosphoesterase, PA-phosphatase related
O5966_12475	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
O5966_12490	COG2183	response to ionizing radiation
O5966_12500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O5966_12500	COG0723	plastoquinol--plastocyanin reductase activity
O5966_12515	COG3243	poly(R)-hydroxyalkanoic acid synthase
O5966_12525	COG1183	phosphatidylcholine synthase activity
O5966_12530	COG1028	Short-chain dehydrogenase reductase Sdr
O5966_12555	COG0668	transmembrane transport
O5966_12575	COG1914	H( )-stimulated, divalent metal cation uptake system
O5966_12610	COG1028	Short-chain dehydrogenase reductase Sdr
O5966_12625	COG0583	DNA-binding transcription factor activity
O5966_12630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O5966_12635	COG3002	Belongs to the UPF0753 family
O5966_12650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O5966_12670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O5966_12680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O5966_12685	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
O5966_12695	COG0776	regulation of translation
O5966_12700	COG0539	negative regulation of cytoplasmic translation
O5966_12705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O5966_12720	COG2957	Belongs to the agmatine deiminase family
O5966_12730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O5966_12755	COG0395	ABC-type sugar transport system, permease component
O5966_12760	COG1175	transmembrane transport
O5966_12790	COG2350	Protein conserved in bacteria
O5966_12795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
O5966_12800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O5966_12805	COG1187	pseudouridine synthase activity
O5966_12830	COG0436	Aminotransferase
O5966_12895	COG0277	FAD linked oxidase domain protein
O5966_12900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O5966_12910	COG0531	amino acid
O5966_12915	COG0531	amino acid
O5966_12920	COG0235	Class ii aldolase
O5966_12925	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
O5966_12955	COG2201	protein-glutamate methylesterase activity
O5966_13005	COG0583	DNA-binding transcription factor activity
O5966_13015	COG3039	Transposase
O5966_13125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O5966_13145	COG0557	exoribonuclease II activity
O5966_13170	COG1960	acyl-CoA dehydrogenase activity
O5966_13175	COG2226	methyltransferase
O5966_13180	COG0646	methionine synthase
O5966_13180	COG1410	methionine synthase
O5966_13185	COG0646	methionine synthase
O5966_13185	COG1410	methionine synthase
O5966_13195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O5966_13205	COG1609	Transcriptional regulator
O5966_13220	COG2900	Belongs to the SlyX family
O5966_13240	COG0386	Belongs to the glutathione peroxidase family
O5966_13250	COG1725	Transcriptional regulator
O5966_13255	COG1131	(ABC) transporter
O5966_13315	COG2850	peptidyl-arginine hydroxylation
O5966_13350	COG1132	(ABC) transporter
O5966_13375	COG0287	Prephenate dehydrogenase
O5966_13375	COG1605	Chorismate mutase
O5966_13380	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
O5966_13385	COG0484	heat shock protein binding
O5966_13390	COG0443	Heat shock 70 kDa protein
O5966_13395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O5966_13405	COG0497	DNA recombination
O5966_13415	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O5966_13420	COG2914	Belongs to the UPF0125 (RnfH) family
O5966_13430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O5966_13445	COG1960	acyl-CoA dehydrogenase activity
O5966_13455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O5966_13510	COG2814	Major facilitator Superfamily
O5966_13515	COG1566	PFAM secretion protein HlyD family protein
O5966_13530	COG2207	Transcriptional regulator
O5966_13555	COG4774	siderophore transport
O5966_13565	COG0367	asparagine synthase
O5966_13580	COG1393	Belongs to the ArsC family
O5966_13595	COG3039	Transposase
O5966_13645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O5966_13660	COG0233	cytoplasmic translational termination
O5966_13670	COG0575	Belongs to the CDS family
O5966_13680	COG0750	zinc metalloprotease
O5966_13700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O5966_13705	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O5966_13725	COG0825	malonyl-CoA metabolic process
O5966_13735	COG4771	TonB-dependent receptor
O5966_13740	COG1131	(ABC) transporter
O5966_13770	COG1981	membrane
O5966_13815	COG2895	sulfate adenylyltransferase (ATP) activity
O5966_13815	COG0529	Catalyzes the synthesis of activated sulfate
O5966_13850	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
O5966_13865	COG2040	homocysteine
O5966_13870	COG0833	amino acid
O5966_13890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O5966_13890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O5966_13900	COG2878	Part of a membrane complex involved in electron transport
O5966_13915	COG1595	DNA-templated transcription, initiation
O5966_13940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O5966_13955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O5966_13960	COG0251	oxidation-reduction process
O5966_13970	COG0392	lysyltransferase activity
O5966_13970	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
O5966_14000	COG3039	Transposase
O5966_14015	COG3039	Transposase
O5966_14030	COG2814	Major facilitator Superfamily
O5966_14035	COG1902	pentaerythritol trinitrate reductase activity
O5966_14045	COG2824	Alkylphosphonate utilization operon protein PhnA
O5966_14060	COG1047	Peptidyl-prolyl cis-trans
O5966_14100	COG3039	Transposase
O5966_14105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O5966_14120	COG1451	nucleotide metabolic process
O5966_14140	COG0183	Belongs to the thiolase family
O5966_14170	COG1793	dna ligase
O5966_14170	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
O5966_14180	COG1793	dna ligase
O5966_14185	COG1201	RNA secondary structure unwinding
O5966_14205	COG1278	Cold shock
O5966_14210	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
O5966_14215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
O5966_14225	COG3046	protein related to deoxyribodipyrimidine photolyase
O5966_14235	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O5966_14260	COG3039	Transposase
O5966_14270	COG2954	triphosphatase activity
O5966_14285	COG1381	Involved in DNA repair and RecF pathway recombination
O5966_14315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O5966_14330	COG1250	3-hydroxyacyl-CoA dehydrogenase
O5966_14330	COG1024	Enoyl-CoA hydratase
O5966_14350	COG1024	Enoyl-CoA hydratase
O5966_14355	COG1960	acyl-CoA dehydrogenase activity
O5966_14425	COG2353	YceI-like domain
O5966_14435	COG2353	YceI-like domain
O5966_14450	COG1760	l-serine dehydratase
O5966_14460	COG0626	cystathionine gamma-synthase activity
O5966_14465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O5966_14470	COG0739	heme binding
O5966_14480	COG1272	protein, Hemolysin III
O5966_14505	COG0463	Glycosyl transferase, family 2
O5966_14515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
O5966_14525	COG4771	TonB-dependent receptor
O5966_14530	COG1309	transcriptional regulator
O5966_14540	COG1960	acyl-CoA dehydrogenase activity
O5966_14570	COG0509	glycine decarboxylation via glycine cleavage system
O5966_14585	COG0330	HflC and HflK could
O5966_14600	COG3956	TIGRFAM MazG family protein
O5966_14610	COG0494	nUDIX hydrolase
O5966_14620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O5966_14625	COG0837	glucose binding
O5966_14640	COG1388	LysM domain
O5966_14640	COG3858	chitin binding
O5966_14650	COG3525	Glycosyl hydrolase, family 20, catalytic domain
O5966_14660	COG1472	Belongs to the glycosyl hydrolase 3 family
O5966_14700	COG3537	Alpha-1,2-mannosidase
O5966_14740	COG3142	Participates in the control of copper homeostasis
O5966_14745	COG1446	asparaginase
O5966_14755	COG2304	oxidoreductase activity
O5966_14760	COG2304	oxidoreductase activity
O5966_14800	COG0784	Response regulator, receiver
O5966_14800	COG0643	Histidine kinase
O5966_14800	COG2198	Histidine kinase
O5966_14805	COG0840	transmembrane signaling receptor activity
O5966_14810	COG0835	chemotaxis
O5966_14825	COG0189	ligase activity
O5966_14835	COG1397	ADP-ribosylglycohydrolase
O5966_14845	COG1199	ATP-dependent helicase activity
O5966_14855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O5966_14860	COG1215	transferase activity, transferring glycosyl groups
O5966_14870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O5966_14890	COG0535	radical SAM domain protein
O5966_14895	COG0535	radical SAM domain protein
O5966_14930	COG1643	Atp-dependent helicase
O5966_14935	COG0783	Belongs to the Dps family
O5966_14940	COG0514	ATP-dependent DNA helicase (RecQ)
O5966_14965	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O5966_15020	COG1187	pseudouridine synthase activity
O5966_15025	COG0602	queuosine metabolic process
O5966_15035	COG2885	chlorophyll binding
O5966_15050	COG0848	biopolymer transport protein
O5966_15060	COG0824	Thioesterase
O5966_15065	COG2255	four-way junction helicase activity
O5966_15075	COG0632	four-way junction helicase activity
O5966_15210	COG3209	COG3209 Rhs family protein
O5966_15230	COG3209	COG3209 Rhs family protein
O5966_15230	COG3209	COG3209 Rhs family protein
O5966_15255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
O5966_15260	COG1845	cytochrome c oxidase, subunit III
O5966_15265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O5966_15280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O5966_15285	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O5966_15295	COG0196	riboflavin kinase activity
O5966_15300	COG0728	peptidoglycan biosynthetic process
O5966_15305	COG0268	Binds directly to 16S ribosomal RNA
O5966_15310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O5966_15315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O5966_15325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O5966_15330	COG0824	Thioesterase
O5966_15345	COG1946	Acyl-CoA thioesterase
O5966_15370	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
O5966_15410	COG1877	trehalose-phosphatase activity
O5966_15415	COG3387	PFAM Glycoside hydrolase 15-related
O5966_15440	COG0564	pseudouridine synthase activity
O5966_15445	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O5966_15450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O5966_15450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O5966_15460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
O5966_15465	COG0045	succinate-CoA ligase (ADP-forming) activity
O5966_15490	COG2184	nucleotidyltransferase activity
O5966_15510	COG2194	sulfuric ester hydrolase activity
O5966_15515	COG4969	Belongs to the N-Me-Phe pilin family
O5966_15525	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
O5966_15545	COG3039	Transposase
O5966_15595	COG1132	(ABC) transporter
O5966_15625	COG0745	RESPONSE REGULATOR receiver
O5966_15630	COG5002	protein histidine kinase activity
O5966_15630	COG5000	phosphorelay sensor kinase activity
O5966_15635	COG0475	glutathione-regulated potassium exporter activity
O5966_15645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O5966_15665	COG1187	pseudouridine synthase activity
O5966_15670	COG5001	Diguanylate cyclase
O5966_15670	COG5002	protein histidine kinase activity
O5966_15785	COG0415	Belongs to the DNA photolyase family
O5966_15790	COG0305	Participates in initiation and elongation during chromosome replication
O5966_15800	COG0367	asparagine synthase
O5966_15815	COG1960	acyl-CoA dehydrogenase activity
O5966_15830	COG0084	hydrolase, TatD family'
O5966_15835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
O5966_15895	COG0735	belongs to the Fur family
O5966_15900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O5966_15930	COG3039	Transposase
O5966_16000	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
O5966_16010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O5966_16025	COG0643	Histidine kinase
O5966_16025	COG2198	Histidine kinase
O5966_16030	COG0840	transmembrane signaling receptor activity
O5966_16035	COG0835	chemotaxis
O5966_16040	COG2200	EAL domain
O5966_16040	COG2199	diguanylate cyclase activity
O5966_16040	COG2202	Pas domain
O5966_16045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O5966_16060	COG3590	peptidase
O5966_16075	COG0588	phosphoglycerate mutase activity
O5966_16080	COG1515	deoxyribonuclease V activity
O5966_16090	COG1741	Belongs to the pirin family
O5966_16150	COG1741	Belongs to the pirin family
O5966_16155	COG1966	Carbon starvation protein
O5966_16160	COG2879	small protein
O5966_16200	COG3706	GGDEF domain
O5966_16200	COG2203	Gaf domain
O5966_16200	COG5001	Diguanylate cyclase
O5966_16200	COG4251	negative regulation of phosphorylation
O5966_16205	COG0629	single-stranded DNA binding
O5966_16210	COG0142	geranyltranstransferase activity
O5966_16240	COG0527	aspartate kinase activity
O5966_16250	COG0384	phenazine biosynthesis protein PhzF
O5966_16260	COG1764	response to oxidative stress
O5966_16275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O5966_16280	COG1678	Uncharacterized ACR, COG1678
O5966_16295	COG0519	Catalyzes the synthesis of GMP from XMP
O5966_16325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
O5966_16385	COG1959	2 iron, 2 sulfur cluster binding
O5966_16390	COG0719	Fe-S assembly protein
O5966_16395	COG0396	ATPase activity
O5966_16400	COG0719	Fe-S assembly protein
O5966_16405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O5966_16420	COG2146	nitrite reductase [NAD(P)H] activity
O5966_16445	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
O5966_16460	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
O5966_16470	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
O5966_16475	COG0174	glutamine synthetase
O5966_16480	COG3328	transposase activity
O5966_16505	COG0326	Molecular chaperone. Has ATPase activity
O5966_16510	COG2207	Transcriptional regulator
O5966_16540	COG0657	acetylesterase activity
O5966_16540	COG2755	lipolytic protein G-D-S-L family
O5966_16565	COG0488	(ABC) transporter
O5966_16600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O5966_16600	COG4651	solute:proton antiporter activity
O5966_16615	COG4772	TonB-dependent receptor
O5966_16625	COG4264	IucA IucC family
O5966_16630	COG2814	Major facilitator Superfamily
O5966_16640	COG0019	diaminopimelate decarboxylase activity
O5966_16705	COG4206	TonB-dependent receptor
O5966_16740	COG0542	response to heat
O5966_16780	COG0534	Mate efflux family protein
O5966_16795	COG0336	Belongs to the RNA methyltransferase TrmD family
O5966_16800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O5966_16805	COG0228	four-way junction DNA binding
O5966_16825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O5966_16835	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O5966_16880	COG1555	photosystem II stabilization
O5966_16885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O5966_16900	COG3178	'Phosphotransferase
O5966_16905	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O5966_16915	COG0628	permease
O5966_16925	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O5966_16940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O5966_16965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O5966_16970	COG0271	Belongs to the BolA IbaG family
O5966_16980	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
O5966_16990	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
O5966_16995	COG1137	ATPase activity
O5966_17010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O5966_17015	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
O5966_17020	COG1660	Displays ATPase and GTPase activities
O5966_17035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O5966_17040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O5966_17045	COG2239	Acts as a magnesium transporter
O5966_17055	COG1294	oxidase, subunit
O5966_17060	COG1271	oxidase subunit
O5966_17075	COG1113	amino acid transport
O5966_17090	COG2197	response regulator
O5966_17095	COG0531	amino acid
O5966_17155	COG0754	glutathionylspermidine amidase activity
O5966_17180	COG1842	Phage shock protein A
O5966_17195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O5966_17200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O5966_17210	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O5966_17240	COG2201	protein-glutamate methylesterase activity
O5966_17290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O5966_17340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O5966_17345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O5966_17375	COG3039	Transposase
O5966_17390	COG0745	RESPONSE REGULATOR receiver
O5966_17395	COG2205	protein histidine kinase activity
O5966_17415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O5966_17445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O5966_17445	COG3453	Protein conserved in bacteria
O5966_17450	COG0725	ABC transporter, periplasmic molybdate-binding protein
O5966_17455	COG4149	molybdate abc transporter
O5966_17460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
O5966_17480	COG0642	Histidine kinase
O5966_17495	COG1028	Short-chain dehydrogenase reductase Sdr
O5966_17505	COG1022	Amp-dependent synthetase and ligase
O5966_17530	COG1376	ErfK ybiS ycfS ynhG family protein
O5966_17535	COG0739	heme binding
O5966_17545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O5966_17550	COG1301	dicarboxylic acid transport
O5966_17570	COG2304	oxidoreductase activity
O5966_17590	COG0714	Associated with various cellular activities
O5966_17635	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
O5966_17660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O5966_17670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O5966_17695	COG1561	YicC-like family, N-terminal region
O5966_17700	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
O5966_17715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O5966_17750	COG0006	proline dipeptidase activity
O5966_17775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O5966_17785	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
O5966_17795	COG2912	Transglutaminase-like superfamily
O5966_17800	COG1773	rubredoxin
O5966_17805	COG0352	thiamine-phosphate diphosphorylase activity
O5966_17875	COG0281	malic enzyme
O5966_17875	COG0280	phosphate acetyltransferase
O5966_17895	COG4191	Histidine kinase
O5966_17910	COG0583	DNA-binding transcription factor activity
O5966_17930	COG2197	response regulator
O5966_17940	COG0642	Histidine kinase
O5966_17955	COG2851	Citrate transporter
O5966_17960	COG1028	Short-chain dehydrogenase reductase Sdr
O5966_17965	COG1609	Transcriptional regulator
O5966_17975	COG2211	Major facilitator Superfamily
O5966_18000	COG1162	GTPase activity
O5966_18025	COG0726	polysaccharide deacetylase
O5966_18030	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
O5966_18060	COG3039	Transposase
O5966_18105	COG0242	peptide deformylase activity
O5966_18125	COG0714	Associated with various cellular activities
O5966_18145	COG0537	adenosine 5'-monophosphoramidase activity
O5966_18175	COG0314	molybdopterin synthase activity
O5966_18180	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O5966_18185	COG0315	cyclic pyranopterin monophosphate synthase activity
O5966_18195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O5966_18200	COG1234	tRNA 3'-trailer cleavage
O5966_18205	COG3642	lipopolysaccharide core region biosynthetic process
O5966_18210	COG0859	PFAM glycosyl transferase family 9
O5966_18220	COG0582	viral genome integration into host DNA
O5966_18280	COG0631	protein serine/threonine phosphatase activity
O5966_18290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O5966_18320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O5966_18360	COG0544	peptidyl-prolyl cis-trans isomerase activity
O5966_18410	COG0473	3-isopropylmalate dehydrogenase activity
O5966_18435	COG4783	chaperone-mediated protein folding
O5966_18450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
O5966_18460	COG0438	transferase activity, transferring glycosyl groups
O5966_18465	COG0671	phosphoesterase, PA-phosphatase related
O5966_18470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O5966_18490	COG2833	Protein of unknown function (DUF455)
O5966_18510	COG0285	dihydrofolate synthase activity
O5966_18520	COG0588	phosphoglycerate mutase activity
O5966_18550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
O5966_18555	COG4208	sulfate ABC transporter
O5966_18560	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
O5966_18565	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
O5966_18570	COG0156	8-amino-7-oxononanoate synthase activity
O5966_18595	COG0604	alcohol dehydrogenase
O5966_18600	COG1902	pentaerythritol trinitrate reductase activity
O5966_18600	COG0446	pyridine nucleotide-disulphide oxidoreductase
O5966_18725	COG3386	PFAM SMP-30 Gluconolaconase
O5966_18745	COG1024	Enoyl-CoA hydratase
O5966_18755	COG0318	PFAM AMP-dependent synthetase and ligase
O5966_18760	COG0583	DNA-binding transcription factor activity
O5966_18800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O5966_18805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O5966_18815	COG2096	Adenosyltransferase
O5966_18820	COG0123	including yeast histone deacetylase and acetoin utilization protein
O5966_18835	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
O5966_18845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O5966_18850	COG2967	ApaG domain
O5966_18875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O5966_18895	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
O5966_18915	COG0642	Histidine kinase
O5966_18930	COG4181	ATPase activity
O5966_18940	COG2175	clavaminate synthase activity
O5966_18995	COG0667	Aldo Keto reductase
O5966_19005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O5966_19010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O5966_19020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O5966_19035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O5966_19080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
O5966_19085	COG2226	methyltransferase
O5966_19130	COG1028	Short-chain dehydrogenase reductase Sdr
O5966_19130	COG3321	synthase
O5966_19130	COG0604	alcohol dehydrogenase
O5966_19140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
O5966_19155	COG0494	nUDIX hydrolase
O5966_19170	COG4942	peptidase
O5966_19170	COG1388	LysM domain
O5966_19180	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
O5966_19195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O5966_19200	COG1181	Belongs to the D-alanine--D-alanine ligase family
O5966_19205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O5966_19220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O5966_19225	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O5966_19240	COG3116	cell division
O5966_19245	COG0275	rRNA processing
O5966_19280	COG0792	nuclease activity
O5966_19285	COG1988	membrane-bound metal-dependent
O5966_19290	COG0277	FAD linked oxidase domain protein
O5966_19295	COG0745	RESPONSE REGULATOR receiver
O5966_19300	COG2205	protein histidine kinase activity
O5966_19310	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
O5966_19315	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
O5966_19335	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O5966_19340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O5966_19345	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O5966_19365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O5966_19365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O5966_19385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O5966_19405	COG0488	(ABC) transporter
O5966_19430	COG3791	Glutathione-dependent formaldehyde-activating
O5966_19460	COG2205	protein histidine kinase activity
O5966_19520	COG0218	Necessary for normal cell division and for the maintenance of normal septation
O5966_19555	COG3039	Transposase
O5966_19570	COG3039	Transposase
O5966_19575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O5966_19585	COG3039	Transposase
O5966_19670	COG1649	PFAM Uncharacterised BCR, COG1649
O5966_19670	COG0726	polysaccharide deacetylase
O5966_19675	COG1215	transferase activity, transferring glycosyl groups
O5966_19685	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O5966_19690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O5966_19695	COG1609	Transcriptional regulator
O5966_19705	COG2188	Transcriptional regulator
O5966_19720	COG3250	beta-galactosidase activity
O5966_19770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O5966_19775	COG4191	Histidine kinase
O5966_19780	COG0784	Response regulator, receiver
O5966_19785	COG4251	negative regulation of phosphorylation
O5966_19790	COG2823	Periplasmic or secreted lipoprotein
O5966_19795	COG0673	inositol 2-dehydrogenase activity
O5966_19800	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
O5966_19835	COG1056	cytidyltransferase-related domain
O5966_19835	COG1051	belongs to the nudix hydrolase family
O5966_19860	COG2921	Belongs to the UPF0250 family
O5966_19875	COG1686	Belongs to the peptidase S11 family
O5966_19880	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
O5966_19965	COG0772	Belongs to the SEDS family
O5966_19980	COG1792	Involved in formation and maintenance of cell shape
O5966_19985	COG1077	Cell shape determining protein MreB Mrl
O5966_19990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O5966_20040	COG2199	diguanylate cyclase activity
O5966_20045	COG0308	aminopeptidase N
O5966_20075	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
O5966_20105	COG0436	Aminotransferase
O5966_20110	COG3039	Transposase
O5966_20130	COG1505	serine-type exopeptidase activity
O5966_20155	COG0181	hydroxymethylbilane synthase activity
O5966_20165	COG3275	phosphorelay sensor kinase activity
O5966_20200	COG0659	secondary active sulfate transmembrane transporter activity
O5966_20205	COG5297	Belongs to the glycosyl hydrolase family 6
O5966_20205	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
O5966_20275	COG0598	Magnesium transport protein CorA
O5966_20285	COG1113	amino acid transport
O5966_20295	COG5297	Belongs to the glycosyl hydrolase family 6
O5966_20300	COG4305	rare lipoprotein A
O5966_20305	COG0697	spore germination
O5966_20365	COG4221	oxidoreductase activity
O5966_20395	COG0456	acetyltransferase
O5966_20405	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
O5966_20445	COG2111	Na H antiporter
O5966_20445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O5966_20450	COG1006	Multisubunit Na H antiporter MnhC subunit
O5966_20455	COG0651	ATP synthesis coupled electron transport
O5966_20465	COG2212	antiporter activity
O5966_20470	COG1320	monovalent cation:proton antiporter activity
O5966_20480	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
O5966_20500	COG3104	oligopeptide transport
O5966_20505	COG3483	tryptophan 2,3-dioxygenase activity
O5966_20555	COG0183	Belongs to the thiolase family
O5966_20625	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
O5966_20630	COG3023	N-Acetylmuramoyl-L-alanine amidase
O5966_20640	COG4948	Mandelate Racemase Muconate Lactonizing
O5966_20665	COG0531	amino acid
O5966_20690	COG4682	membrane
O5966_20695	COG2133	pyrroloquinoline quinone binding
O5966_20735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O5966_20740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O5966_20750	COG1610	YqeY-like protein
O5966_20760	COG1295	ribonuclease BN
O5966_20765	COG0358	DNA primase activity
O5966_20830	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
O5966_20845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O5966_20895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O5966_20900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O5966_20905	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
O5966_20915	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
O5966_20920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O5966_20930	COG0134	indole-3-glycerol-phosphate synthase activity
O5966_20935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O5966_21000	COG3039	Transposase
O5966_21035	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O5966_21035	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O5966_21045	COG1473	amidohydrolase
O5966_21050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O5966_21055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O5966_21065	COG5383	Protein conserved in bacteria
O5966_21100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O5966_21105	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
O5966_21120	COG0028	Belongs to the TPP enzyme family
O5966_21130	COG4191	Histidine kinase
O5966_21155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O5966_21170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O5966_21175	COG3177	Filamentation induced by cAMP protein fic
O5966_21190	COG0596	Alpha beta hydrolase
O5966_21195	COG0727	PFAM Uncharacterised protein family (UPF0153)
O5966_21200	COG0318	PFAM AMP-dependent synthetase and ligase
O5966_21205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O5966_21255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O5966_21265	COG0129	dihydroxy-acid dehydratase activity
O5966_21285	COG3039	Transposase
O5966_21295	COG0408	coproporphyrinogen oxidase activity
O5966_21335	COG0232	Belongs to the dGTPase family. Type 2 subfamily
O5966_21405	COG2353	YceI-like domain
O5966_21435	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
O5966_21450	COG3386	PFAM SMP-30 Gluconolaconase
O5966_21475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O5966_21495	COG0459	protein refolding
O5966_21520	COG1252	NADH dehydrogenase
O5966_21530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O5966_21535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O5966_21540	COG2201	protein-glutamate methylesterase activity
O5966_21545	COG2177	Part of the ABC transporter FtsEX involved in
O5966_21550	COG2884	Cell division ATP-binding protein ftsE
O5966_21560	COG3118	belongs to the thioredoxin family
O5966_21565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
O5966_21580	COG0729	surface antigen
O5966_21585	COG2911	Protein conserved in bacteria
O5966_21635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O5966_21685	COG1733	regulation of RNA biosynthetic process
O5966_21690	COG0702	epimerase
O5966_21720	COG0583	DNA-binding transcription factor activity
O5966_21725	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
O5966_21745	COG0745	RESPONSE REGULATOR receiver
O5966_21775	COG1902	pentaerythritol trinitrate reductase activity
O5966_21780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O5966_21790	COG2814	Major facilitator Superfamily
O5966_21795	COG0583	DNA-binding transcription factor activity
O5966_21810	COG0084	hydrolase, TatD family'
O5966_21855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
O5966_21880	COG2351	hydroxyisourate hydrolase activity
O5966_21940	COG4770	biotin carboxylase activity
O5966_21945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O5966_21950	COG1960	acyl-CoA dehydrogenase activity
O5966_22000	COG0523	cobalamin synthesis protein
O5966_22020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
O5966_22040	COG4771	TonB-dependent receptor
O5966_22045	COG0457	Tetratricopeptide repeat
O5966_22055	COG0752	glycyl-tRNA synthetase alpha subunit
O5966_22060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O5966_22075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O5966_22075	COG0519	Catalyzes the synthesis of GMP from XMP
O5966_22085	COG0805	protein transport
O5966_22095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O5966_22105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O5966_22130	COG2974	May be involved in recombination
O5966_22135	COG0037	tRNA processing
O5966_22155	COG3661	Belongs to the glycosyl hydrolase 67 family
O5966_22165	COG4948	Mandelate Racemase Muconate Lactonizing
O5966_22175	COG1472	Belongs to the glycosyl hydrolase 3 family
O5966_22180	COG0246	Mannitol dehydrogenase
O5966_22205	COG3693	PFAM glycoside hydrolase, family 10
O5966_22230	COG2211	Major facilitator Superfamily
O5966_22315	COG1846	Transcriptional regulator
O5966_22320	COG1764	response to oxidative stress
O5966_22405	COG3549	Plasmid maintenance system killer
O5966_22415	COG1074	ATP-dependent DNA helicase activity
O5966_22420	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
O5966_22435	COG1196	nuclear chromosome segregation
O5966_22470	COG2032	superoxide dismutase activity
O5966_22475	COG2032	superoxide dismutase activity
O5966_22480	COG2204	response regulator
O5966_22485	COG3852	Histidine kinase
O5966_22490	COG0004	ammonium transporteR
O5966_22495	COG0347	Belongs to the P(II) protein family
O5966_22500	COG0174	glutamine synthetase
O5966_22505	COG1968	undecaprenyl-diphosphatase activity
O5966_22545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O5966_22555	COG2062	phosphohistidine phosphatase, SixA
O5966_22560	COG0489	protein tyrosine kinase activity
O5966_22580	COG1396	sequence-specific DNA binding
O5966_22585	COG3550	peptidyl-serine autophosphorylation
O5966_22590	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
O5966_22595	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O5966_22610	COG0517	IMP dehydrogenase activity
O5966_22610	COG1125	glycine betaine transport
O5966_22625	COG1119	ATPase activity
O5966_22635	COG1752	Esterase of the alpha-beta hydrolase superfamily
O5966_22675	COG0656	L-ascorbic acid biosynthetic process
O5966_22680	COG2130	NADP-dependent
O5966_22685	COG0667	Aldo Keto reductase
O5966_22695	COG1187	pseudouridine synthase activity
O5966_22705	COG1643	Atp-dependent helicase
O5966_22710	COG4807	Protein conserved in bacteria
O5966_22715	COG4948	Mandelate Racemase Muconate Lactonizing
O5966_22720	COG0179	Fumarylacetoacetate (FAA) hydrolase
O5966_22725	COG1028	Short-chain dehydrogenase reductase Sdr
O5966_22785	COG3162	membrane
O5966_22790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O5966_22805	COG0708	Exodeoxyribonuclease III
O5966_22820	COG2091	lysine biosynthetic process via aminoadipic acid
O5966_22830	COG3540	Alkaline phosphatase
O5966_22835	COG0357	Ribosomal RNA small subunit methyltransferase G
O5966_22865	COG2159	amidohydrolase
O5966_22875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O5966_22880	COG0583	DNA-binding transcription factor activity
O5966_22885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O5966_22900	COG0210	DNA helicase
O5966_22915	COG0531	amino acid
O5966_22925	COG1322	Protein conserved in bacteria
O5966_22935	COG0386	Belongs to the glutathione peroxidase family
O5966_22990	COG0793	Belongs to the peptidase S41A family
O5966_22995	COG4942	peptidase
O5966_23005	COG2234	aminopeptidase activity
O5966_23050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O5966_23055	COG0302	gtp cyclohydrolase
O5966_23080	COG0477	Major facilitator Superfamily
O5966_23145	COG1929	Belongs to the glycerate kinase type-1 family
O5966_23150	COG2271	Major facilitator Superfamily
O5966_23165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O5966_23170	COG0861	Integral membrane protein TerC family
O5966_23185	COG0584	glycerophosphoryl diester phosphodiesterase
O5966_23195	COG0671	phosphoesterase, PA-phosphatase related
O5966_23200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O5966_23205	COG0726	polysaccharide deacetylase