locus-tag	class	description
BRN51_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BRN51_00025	COG0187	DNA topoisomerase II activity
BRN51_00035	COG0501	Belongs to the peptidase M48B family
BRN51_00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BRN51_00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN51_00095	COG4772	TonB-dependent receptor
BRN51_00110	COG3039	Transposase
BRN51_00135	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BRN51_00145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN51_00245	COG2826	transposase and inactivated derivatives, IS30 family
BRN51_00270	COG3039	Transposase
BRN51_00280	COG1090	epimerase
BRN51_00290	COG0642	Histidine kinase
BRN51_00300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRN51_00405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BRN51_00485	COG3264	Mechanosensitive ion channel
BRN51_00485	COG1511	domain protein
BRN51_00500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRN51_00510	COG2354	Protein conserved in bacteria
BRN51_00520	COG0745	RESPONSE REGULATOR receiver
BRN51_00520	COG3706	GGDEF domain
BRN51_00525	COG0297	glycogen (starch) synthase activity
BRN51_00535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BRN51_00560	COG0702	epimerase
BRN51_00570	COG1858	cytochrome C peroxidase
BRN51_00650	COG0513	Belongs to the DEAD box helicase family
BRN51_00660	COG3039	Transposase
BRN51_00710	COG1136	(ABC) transporter
BRN51_00735	COG1136	(ABC) transporter
BRN51_00780	COG1272	protein, Hemolysin III
BRN51_00785	COG1205	dead DEAH box helicase
BRN51_00785	COG1111	helicase
BRN51_00850	COG0070	glutamate synthase
BRN51_00850	COG0067	glutamate synthase
BRN51_00850	COG0069	glutamate synthase activity
BRN51_00855	COG0493	'glutamate synthase
BRN51_00910	COG1609	Transcriptional regulator
BRN51_00945	COG0366	Alpha amylase catalytic
BRN51_00950	COG0366	Alpha amylase catalytic
BRN51_01020	COG0606	chelatase, subunit chli
BRN51_01075	COG1166	arginine decarboxylase activity
BRN51_01090	COG3501	Rhs element vgr protein
BRN51_01170	COG1028	Short-chain dehydrogenase reductase Sdr
BRN51_01195	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BRN51_01210	COG0210	DNA helicase
BRN51_01230	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BRN51_01270	COG2937	Belongs to the GPAT DAPAT family
BRN51_01320	COG1752	Esterase of the alpha-beta hydrolase superfamily
BRN51_01330	COG1119	ATPase activity
BRN51_01345	COG0517	IMP dehydrogenase activity
BRN51_01345	COG1125	glycine betaine transport
BRN51_01360	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN51_01365	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BRN51_01370	COG3550	peptidyl-serine autophosphorylation
BRN51_01375	COG1396	sequence-specific DNA binding
BRN51_01395	COG0489	protein tyrosine kinase activity
BRN51_01400	COG2062	phosphohistidine phosphatase, SixA
BRN51_01410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN51_01460	COG0174	glutamine synthetase
BRN51_01465	COG0347	Belongs to the P(II) protein family
BRN51_01470	COG0004	ammonium transporteR
BRN51_01475	COG3852	Histidine kinase
BRN51_01480	COG2204	response regulator
BRN51_01485	COG2032	superoxide dismutase activity
BRN51_01490	COG2032	superoxide dismutase activity
BRN51_01525	COG1196	nuclear chromosome segregation
BRN51_01530	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BRN51_01535	COG1074	ATP-dependent DNA helicase activity
BRN51_01545	COG3549	Plasmid maintenance system killer
BRN51_01645	COG1764	response to oxidative stress
BRN51_01650	COG1846	Transcriptional regulator
BRN51_01695	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BRN51_01735	COG2211	Major facilitator Superfamily
BRN51_01760	COG3693	PFAM glycoside hydrolase, family 10
BRN51_01785	COG0246	Mannitol dehydrogenase
BRN51_01790	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN51_01800	COG4948	Mandelate Racemase Muconate Lactonizing
BRN51_01810	COG3661	Belongs to the glycosyl hydrolase 67 family
BRN51_01830	COG0037	tRNA processing
BRN51_01835	COG2974	May be involved in recombination
BRN51_01865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BRN51_01875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BRN51_01885	COG0805	protein transport
BRN51_01895	COG0519	Catalyzes the synthesis of GMP from XMP
BRN51_01895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRN51_01920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRN51_01925	COG0752	glycyl-tRNA synthetase alpha subunit
BRN51_01935	COG0457	Tetratricopeptide repeat
BRN51_01940	COG4771	TonB-dependent receptor
BRN51_01955	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BRN51_01975	COG0523	cobalamin synthesis protein
BRN51_02030	COG1960	acyl-CoA dehydrogenase activity
BRN51_02035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BRN51_02105	COG2351	hydroxyisourate hydrolase activity
BRN51_02130	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRN51_02180	COG0084	hydrolase, TatD family'
BRN51_02195	COG0583	DNA-binding transcription factor activity
BRN51_02200	COG2814	Major facilitator Superfamily
BRN51_02210	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BRN51_02215	COG1902	pentaerythritol trinitrate reductase activity
BRN51_02245	COG0745	RESPONSE REGULATOR receiver
BRN51_02265	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRN51_02270	COG0583	DNA-binding transcription factor activity
BRN51_02305	COG0702	epimerase
BRN51_02310	COG1733	regulation of RNA biosynthetic process
BRN51_02370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRN51_02385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRN51_02420	COG2911	Protein conserved in bacteria
BRN51_02425	COG0729	surface antigen
BRN51_02440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BRN51_02445	COG3118	belongs to the thioredoxin family
BRN51_02455	COG2884	Cell division ATP-binding protein ftsE
BRN51_02460	COG2177	Part of the ABC transporter FtsEX involved in
BRN51_02465	COG3437	response regulator, receiver
BRN51_02475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRN51_02485	COG1252	NADH dehydrogenase
BRN51_02505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BRN51_02520	COG4771	TonB-dependent receptor
BRN51_02535	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BRN51_02575	COG3386	PFAM SMP-30 Gluconolaconase
BRN51_02590	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRN51_02625	COG0778	Nitroreductase
BRN51_02630	COG2353	YceI-like domain
BRN51_02740	COG3039	Transposase
BRN51_02775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BRN51_02815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRN51_02820	COG0318	PFAM AMP-dependent synthetase and ligase
BRN51_02830	COG0596	Alpha beta hydrolase
BRN51_02845	COG3177	Filamentation induced by cAMP protein fic
BRN51_02850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRN51_02865	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BRN51_02890	COG4191	Histidine kinase
BRN51_02895	COG0028	Belongs to the TPP enzyme family
BRN51_02915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BRN51_02960	COG5383	Protein conserved in bacteria
BRN51_02975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN51_02980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN51_02990	COG1473	amidohydrolase
BRN51_03085	COG0134	indole-3-glycerol-phosphate synthase activity
BRN51_03175	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BRN51_03190	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BRN51_03255	COG3039	Transposase
BRN51_03280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BRN51_03310	COG0534	Mate efflux family protein
BRN51_03315	COG0616	signal peptide processing
BRN51_03325	COG1028	Short-chain dehydrogenase reductase Sdr
BRN51_03345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BRN51_03345	COG1754	DNA topoisomerase type I activity
BRN51_03365	COG0758	DNA mediated transformation
BRN51_03370	COG1652	LysM domain
BRN51_03375	COG0242	peptide deformylase activity
BRN51_03385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BRN51_03385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRN51_03435	COG1560	Kdo2-lipid A biosynthetic process
BRN51_03445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRN51_03590	COG0358	DNA primase activity
BRN51_03595	COG1295	ribonuclease BN
BRN51_03615	COG1610	YqeY-like protein
BRN51_03620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BRN51_03630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BRN51_03670	COG2133	pyrroloquinoline quinone binding
BRN51_03675	COG4682	membrane
BRN51_03705	COG0531	amino acid
BRN51_03740	COG4948	Mandelate Racemase Muconate Lactonizing
BRN51_03750	COG3023	N-Acetylmuramoyl-L-alanine amidase
BRN51_03755	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BRN51_03830	COG0183	Belongs to the thiolase family
BRN51_03865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BRN51_03880	COG3104	oligopeptide transport
BRN51_03910	COG1320	monovalent cation:proton antiporter activity
BRN51_03915	COG2212	antiporter activity
BRN51_03925	COG0651	ATP synthesis coupled electron transport
BRN51_03930	COG1006	Multisubunit Na H antiporter MnhC subunit
BRN51_03935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRN51_03935	COG2111	Na H antiporter
BRN51_03980	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BRN51_03990	COG0456	acetyltransferase
BRN51_04020	COG4221	oxidoreductase activity
BRN51_04080	COG0697	spore germination
BRN51_04085	COG4305	rare lipoprotein A
BRN51_04090	COG5297	Belongs to the glycosyl hydrolase family 6
BRN51_04100	COG1113	amino acid transport
BRN51_04110	COG0598	Magnesium transport protein CorA
BRN51_04130	COG3039	Transposase
BRN51_04195	COG5297	Belongs to the glycosyl hydrolase family 6
BRN51_04195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN51_04200	COG0659	secondary active sulfate transmembrane transporter activity
BRN51_04255	COG3275	phosphorelay sensor kinase activity
BRN51_04290	COG1505	serine-type exopeptidase activity
BRN51_04335	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BRN51_04370	COG0308	aminopeptidase N
BRN51_04375	COG2199	diguanylate cyclase activity
BRN51_04425	COG1077	Cell shape determining protein MreB Mrl
BRN51_04430	COG1792	Involved in formation and maintenance of cell shape
BRN51_04445	COG0772	Belongs to the SEDS family
BRN51_04485	COG1388	LysM domain
BRN51_04485	COG5632	N-Acetylmuramoyl-L-alanine amidase
BRN51_04485	COG3409	Peptidoglycan-binding domain 1 protein
BRN51_04500	COG2951	lytic endotransglycosylase activity
BRN51_04505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BRN51_04515	COG1686	Belongs to the peptidase S11 family
BRN51_04555	COG1056	cytidyltransferase-related domain
BRN51_04555	COG1051	belongs to the nudix hydrolase family
BRN51_04590	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BRN51_04595	COG0673	inositol 2-dehydrogenase activity
BRN51_04600	COG2823	Periplasmic or secreted lipoprotein
BRN51_04605	COG4251	negative regulation of phosphorylation
BRN51_04610	COG0784	Response regulator, receiver
BRN51_04615	COG4191	Histidine kinase
BRN51_04620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BRN51_04670	COG3250	beta-galactosidase activity
BRN51_04695	COG1609	Transcriptional regulator
BRN51_04700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRN51_04705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BRN51_04715	COG1215	transferase activity, transferring glycosyl groups
BRN51_04720	COG0726	polysaccharide deacetylase
BRN51_04720	COG1649	PFAM Uncharacterised BCR, COG1649
BRN51_04855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRN51_04870	COG3039	Transposase
BRN51_04950	COG2205	protein histidine kinase activity
BRN51_04955	COG0745	RESPONSE REGULATOR receiver
BRN51_05005	COG0488	(ABC) transporter
BRN51_05045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRN51_05045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRN51_05075	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BRN51_05100	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BRN51_05105	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BRN51_05115	COG2205	protein histidine kinase activity
BRN51_05120	COG0745	RESPONSE REGULATOR receiver
BRN51_05125	COG0277	FAD linked oxidase domain protein
BRN51_05130	COG1988	membrane-bound metal-dependent
BRN51_05175	COG3116	cell division
BRN51_05190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BRN51_05195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRN51_05215	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRN51_05220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BRN51_05245	COG4942	peptidase
BRN51_05245	COG1388	LysM domain
BRN51_05250	COG0653	protein targeting
BRN51_05260	COG0494	nUDIX hydrolase
BRN51_05275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BRN51_05290	COG1028	Short-chain dehydrogenase reductase Sdr
BRN51_05290	COG0604	alcohol dehydrogenase
BRN51_05290	COG3321	synthase
BRN51_05345	COG2226	methyltransferase
BRN51_05405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BRN51_05420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRN51_05440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN51_05445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BRN51_05455	COG3039	Transposase
BRN51_05465	COG0667	Aldo Keto reductase
BRN51_05515	COG2175	clavaminate synthase activity
BRN51_05525	COG4181	ATPase activity
BRN51_05540	COG0642	Histidine kinase
BRN51_05560	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BRN51_05600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BRN51_05620	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BRN51_05635	COG0123	including yeast histone deacetylase and acetoin utilization protein
BRN51_05640	COG2096	Adenosyltransferase
BRN51_05650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRN51_05655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRN51_05695	COG0583	DNA-binding transcription factor activity
BRN51_05700	COG0318	PFAM AMP-dependent synthetase and ligase
BRN51_05710	COG1024	Enoyl-CoA hydratase
BRN51_05730	COG3386	PFAM SMP-30 Gluconolaconase
BRN51_05740	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BRN51_05815	COG0745	RESPONSE REGULATOR receiver
BRN51_05815	COG3706	GGDEF domain
BRN51_05830	COG3039	Transposase
BRN51_05845	COG3039	Transposase
BRN51_05875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BRN51_05905	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BRN51_05910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN51_05920	COG0583	DNA-binding transcription factor activity
BRN51_05925	COG3634	alkyl hydroperoxide reductase activity
BRN51_05935	COG2890	protein-(glutamine-N5) methyltransferase activity
BRN51_05975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRN51_05975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRN51_05990	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BRN51_06010	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BRN51_06015	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BRN51_06045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BRN51_06060	COG1404	Belongs to the peptidase S8 family
BRN51_06065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BRN51_06100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRN51_06120	COG0521	Mo-molybdopterin cofactor biosynthetic process
BRN51_06135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BRN51_06160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BRN51_06175	COG0012	GTP binding
BRN51_06205	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BRN51_06210	COG0250	Participates in transcription elongation, termination and antitermination
BRN51_06225	COG0081	regulation of translation
BRN51_06250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BRN51_06290	COG0089	rRNA binding
BRN51_06315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BRN51_06320	COG0255	Belongs to the universal ribosomal protein uL29 family
BRN51_06325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BRN51_06335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BRN51_06345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BRN51_06360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BRN51_06365	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BRN51_06370	COG1841	ribosomal large subunit assembly
BRN51_06380	COG0201	protein transport
BRN51_06385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BRN51_06400	COG0202	RNA polymerase activity
BRN51_06405	COG0203	ribosomal protein L17
BRN51_06470	COG3551	Protein conserved in bacteria
BRN51_06500	COG2194	sulfuric ester hydrolase activity
BRN51_06510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BRN51_06515	COG0745	RESPONSE REGULATOR receiver
BRN51_06520	COG0642	Histidine kinase
BRN51_06530	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BRN51_06535	COG2894	cell division
BRN51_06555	COG4585	Histidine kinase
BRN51_06560	COG2197	response regulator
BRN51_06575	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BRN51_06600	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BRN51_06605	COG2963	transposase activity
BRN51_06655	COG3501	Rhs element vgr protein
BRN51_06665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN51_06675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN51_06710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN51_06745	COG3039	Transposase
BRN51_06765	COG3039	Transposase
BRN51_06785	COG3039	Transposase
BRN51_06810	COG1741	Belongs to the pirin family
BRN51_06820	COG1515	deoxyribonuclease V activity
BRN51_06825	COG0588	phosphoglycerate mutase activity
BRN51_06845	COG3590	peptidase
BRN51_06860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BRN51_06865	COG2202	Pas domain
BRN51_06865	COG2200	EAL domain
BRN51_06865	COG2199	diguanylate cyclase activity
BRN51_06870	COG0835	chemotaxis
BRN51_06875	COG0840	transmembrane signaling receptor activity
BRN51_06890	COG3039	Transposase
BRN51_06905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BRN51_06915	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BRN51_06930	COG2205	protein histidine kinase activity
BRN51_06960	COG3039	Transposase
BRN51_07010	COG3039	Transposase
BRN51_07040	COG0735	belongs to the Fur family
BRN51_07100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BRN51_07105	COG0084	hydrolase, TatD family'
BRN51_07120	COG1960	acyl-CoA dehydrogenase activity
BRN51_07135	COG0367	asparagine synthase
BRN51_07145	COG0305	Participates in initiation and elongation during chromosome replication
BRN51_07150	COG0415	Belongs to the DNA photolyase family
BRN51_07170	COG1028	Short-chain dehydrogenase reductase Sdr
BRN51_07270	COG5001	Diguanylate cyclase
BRN51_07270	COG5002	protein histidine kinase activity
BRN51_07275	COG1187	pseudouridine synthase activity
BRN51_07310	COG0475	glutathione-regulated potassium exporter activity
BRN51_07315	COG5000	phosphorelay sensor kinase activity
BRN51_07315	COG5002	protein histidine kinase activity
BRN51_07320	COG0745	RESPONSE REGULATOR receiver
BRN51_07350	COG1132	(ABC) transporter
BRN51_07390	COG3209	COG3209 Rhs family protein
BRN51_07400	COG3039	Transposase
BRN51_07440	COG3039	Transposase
BRN51_07450	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BRN51_07460	COG4969	Belongs to the N-Me-Phe pilin family
BRN51_07465	COG2194	sulfuric ester hydrolase activity
BRN51_07485	COG2184	nucleotidyltransferase activity
BRN51_07510	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BRN51_07520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BRN51_07520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRN51_07525	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN51_07530	COG0564	pseudouridine synthase activity
BRN51_07555	COG3387	PFAM Glycoside hydrolase 15-related
BRN51_07560	COG1877	trehalose-phosphatase activity
BRN51_07615	COG1595	DNA-templated transcription, initiation
BRN51_07625	COG1946	Acyl-CoA thioesterase
BRN51_07640	COG0824	Thioesterase
BRN51_07645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BRN51_07665	COG0268	Binds directly to 16S ribosomal RNA
BRN51_07670	COG0728	peptidoglycan biosynthetic process
BRN51_07675	COG0196	riboflavin kinase activity
BRN51_07705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BRN51_07710	COG1845	cytochrome c oxidase, subunit III
BRN51_07715	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BRN51_07725	COG3501	Rhs element vgr protein
BRN51_07800	COG3039	Transposase
BRN51_07835	COG3039	Transposase
BRN51_07890	COG3501	Rhs element vgr protein
BRN51_07900	COG3039	Transposase
BRN51_07965	COG3501	Rhs element vgr protein
BRN51_08000	COG0631	protein serine/threonine phosphatase activity
BRN51_08005	COG0515	serine threonine protein kinase
BRN51_08035	COG1858	cytochrome C peroxidase
BRN51_08100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN51_08105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN51_08125	COG2201	protein-glutamate methylesterase activity
BRN51_08170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRN51_08190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRN51_08205	COG1595	DNA-templated transcription, initiation
BRN51_08255	COG2244	polysaccharide biosynthetic process
BRN51_08285	COG2264	protein methyltransferase activity
BRN51_08295	COG0438	transferase activity, transferring glycosyl groups
BRN51_08310	COG1136	(ABC) transporter
BRN51_08315	COG1132	(ABC) transporter
BRN51_08325	COG0477	Major facilitator Superfamily
BRN51_08345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BRN51_08360	COG1253	flavin adenine dinucleotide binding
BRN51_08375	COG0306	phosphate transporter
BRN51_08430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BRN51_08450	COG2840	Smr protein MutS2
BRN51_08465	COG1238	metal cluster binding
BRN51_08480	COG1534	Rna-binding protein
BRN51_08490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BRN51_08495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BRN51_08500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BRN51_08505	COG1923	regulation of RNA biosynthetic process
BRN51_08510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BRN51_08515	COG1546	Belongs to the CinA family
BRN51_08540	COG2137	regulation of response to DNA damage stimulus
BRN51_08550	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BRN51_08570	COG0305	Participates in initiation and elongation during chromosome replication
BRN51_08575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BRN51_08600	COG1741	Belongs to the pirin family
BRN51_08605	COG0583	DNA-binding transcription factor activity
BRN51_08635	COG0351	phosphomethylpyrimidine kinase
BRN51_08645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BRN51_08650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRN51_08665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRN51_08675	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BRN51_08680	COG3734	2-keto-3-deoxy-galactonokinase
BRN51_08695	COG0800	Aldolase
BRN51_08710	COG1501	Belongs to the glycosyl hydrolase 31 family
BRN51_08720	COG1070	Carbohydrate kinase
BRN51_08730	COG0477	Major facilitator Superfamily
BRN51_08800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BRN51_08805	COG2258	MOSC domain
BRN51_08815	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BRN51_08820	COG0505	Belongs to the CarA family
BRN51_08830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BRN51_08835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN51_08845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BRN51_08905	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BRN51_08920	COG2198	Histidine kinase
BRN51_08920	COG2205	protein histidine kinase activity
BRN51_08920	COG0784	Response regulator, receiver
BRN51_08925	COG1024	Enoyl-CoA hydratase
BRN51_08930	COG0318	PFAM AMP-dependent synthetase and ligase
BRN51_08960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN51_08995	COG0840	transmembrane signaling receptor activity
BRN51_09020	COG0835	chemotaxis
BRN51_09045	COG0840	transmembrane signaling receptor activity
BRN51_09050	COG0840	transmembrane signaling receptor activity
BRN51_09055	COG0840	transmembrane signaling receptor activity
BRN51_09060	COG0840	transmembrane signaling receptor activity
BRN51_09070	COG0840	transmembrane signaling receptor activity
BRN51_09080	COG0840	transmembrane signaling receptor activity
BRN51_09095	COG0840	transmembrane signaling receptor activity
BRN51_09120	COG0745	RESPONSE REGULATOR receiver
BRN51_09130	COG0835	chemotaxis
BRN51_09135	COG1192	Involved in chromosome partitioning
BRN51_09140	COG1360	Flagellar Motor Protein
BRN51_09145	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BRN51_09165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRN51_09175	COG4771	TonB-dependent receptor
BRN51_09220	COG3501	Rhs element vgr protein
BRN51_09240	COG3501	Rhs element vgr protein
BRN51_09260	COG3501	Rhs element vgr protein
BRN51_09305	COG3039	Transposase
BRN51_09315	COG3039	Transposase
BRN51_09330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRN51_09330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRN51_09335	COG1105	Belongs to the carbohydrate kinase PfkB family
BRN51_09340	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN51_09340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRN51_09345	COG1609	Transcriptional regulator
BRN51_09370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN51_09375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN51_09385	COG2902	Dehydrogenase
BRN51_09395	COG3039	Transposase
BRN51_09405	COG5002	protein histidine kinase activity
BRN51_09405	COG2205	protein histidine kinase activity
BRN51_09405	COG0784	Response regulator, receiver
BRN51_09410	COG2733	membrane
BRN51_09420	COG1121	(ABC) transporter
BRN51_09445	COG0243	molybdopterin cofactor binding
BRN51_09455	COG0477	Major facilitator Superfamily
BRN51_09460	COG0745	RESPONSE REGULATOR receiver
BRN51_09460	COG3706	GGDEF domain
BRN51_09465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN51_09470	COG0174	glutamine synthetase
BRN51_09515	COG3842	ATPase activity
BRN51_09520	COG1176	ABC-type spermidine putrescine transport system, permease component I
BRN51_09525	COG1177	transmembrane transport
BRN51_09535	COG1012	belongs to the aldehyde dehydrogenase family
BRN51_09550	COG4535	Mg2 and Co2 transporter CorC
BRN51_09570	COG1702	phosphate starvation-inducible protein PhoH
BRN51_09575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BRN51_09595	COG0741	lytic transglycosylase activity
BRN51_09605	COG0723	plastoquinol--plastocyanin reductase activity
BRN51_09610	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BRN51_09615	COG2857	Cytochrome c1
BRN51_09620	COG0625	glutathione transferase activity
BRN51_09625	COG2969	positive regulation of protein catabolic process
BRN51_09670	COG3328	transposase activity
BRN51_09760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN51_09775	COG1570	exodeoxyribonuclease VII activity
BRN51_09780	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRN51_09785	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BRN51_09785	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BRN51_09790	COG0802	atpase or kinase
BRN51_09795	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRN51_09825	COG1028	Short-chain dehydrogenase reductase Sdr
BRN51_09835	COG0501	Belongs to the peptidase M48B family
BRN51_09845	COG2081	HI0933 family
BRN51_09850	COG4681	YaeQ
BRN51_09865	COG0625	glutathione transferase activity
BRN51_09875	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BRN51_09880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BRN51_09885	COG0513	Belongs to the DEAD box helicase family
BRN51_09920	COG0483	inositol monophosphate 1-phosphatase activity
BRN51_09935	COG5001	Diguanylate cyclase
BRN51_09935	COG3300	MHYT domain
BRN51_09940	COG1509	lysine 2,3-aminomutase activity
BRN51_09955	COG0402	S-adenosylhomocysteine deaminase activity
BRN51_09990	COG4677	pectinesterase activity
BRN51_10015	COG3039	Transposase
BRN51_10050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BRN51_10060	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BRN51_10075	COG2166	iron-sulfur cluster assembly
BRN51_10090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BRN51_10095	COG0137	argininosuccinate synthase activity
BRN51_10105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRN51_10110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BRN51_10175	COG1271	oxidase subunit
BRN51_10185	COG4988	ABC transporter
BRN51_10190	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BRN51_10315	COG0742	ribosomal rna small subunit methyltransferase
BRN51_10335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRN51_10340	COG0405	Gamma-glutamyltransferase
BRN51_10410	COG3039	Transposase
BRN51_10455	COG1862	Preprotein translocase
BRN51_10465	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRN51_10495	COG3328	transposase activity
BRN51_10515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRN51_10525	COG0704	Plays a role in the regulation of phosphate uptake
BRN51_10540	COG0573	inorganic phosphate transmembrane transporter activity
BRN51_10545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BRN51_10580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BRN51_10590	COG1024	Enoyl-CoA hydratase
BRN51_10600	COG0494	nUDIX hydrolase
BRN51_10670	COG0667	Aldo Keto reductase
BRN51_10680	COG2925	Exonuclease
BRN51_10690	COG3844	kynureninase activity
BRN51_10710	COG0288	reversible hydration of carbon dioxide
BRN51_10745	COG0316	Belongs to the HesB IscA family
BRN51_10770	COG3115	cell septum assembly
BRN51_10785	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BRN51_10825	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BRN51_10835	COG2986	histidine ammonia-lyase
BRN51_10885	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BRN51_10890	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BRN51_10895	COG1605	Chorismate mutase
BRN51_10895	COG0077	Prephenate dehydratase
BRN51_10930	COG4566	intracellular signal transduction
BRN51_10985	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRN51_11000	COG0617	tRNA 3'-terminal CCA addition
BRN51_11010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BRN51_11015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BRN51_11025	COG0166	Belongs to the GPI family
BRN51_11050	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN51_11070	COG4251	negative regulation of phosphorylation
BRN51_11070	COG3706	GGDEF domain
BRN51_11070	COG2203	Gaf domain
BRN51_11070	COG5001	Diguanylate cyclase
BRN51_11160	COG0386	Belongs to the glutathione peroxidase family
BRN51_11210	COG3706	GGDEF domain
BRN51_11235	COG1247	-acetyltransferase
BRN51_11255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BRN51_11285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRN51_11305	COG1393	Belongs to the ArsC family
BRN51_11310	COG0431	NADPH-dependent FMN reductase
BRN51_11315	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BRN51_11320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BRN51_11345	COG2205	protein histidine kinase activity
BRN51_11345	COG0784	Response regulator, receiver
BRN51_11345	COG5002	protein histidine kinase activity
BRN51_11380	COG0800	Aldolase
BRN51_11385	COG0129	dihydroxy-acid dehydratase activity
BRN51_11390	COG0363	glucosamine-6-phosphate deaminase activity
BRN51_11400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRN51_11415	COG0354	folic acid binding
BRN51_11430	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BRN51_11445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BRN51_11460	COG4591	ABC-type transport system involved in lipoprotein release permease component
BRN51_11490	COG0811	peptide transport
BRN51_11515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BRN51_11560	COG3328	transposase activity
BRN51_11580	COG2801	Transposase and inactivated derivatives
BRN51_11590	COG2201	protein-glutamate methylesterase activity
BRN51_11625	COG0653	protein targeting
BRN51_11785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BRN51_11785	COG0140	phosphoribosyl-ATP diphosphatase activity
BRN51_11850	COG0124	histidyl-tRNA synthetase
BRN51_11865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BRN51_11910	COG1012	belongs to the aldehyde dehydrogenase family
BRN51_11925	COG0167	dihydroorotate dehydrogenase activity
BRN51_11930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BRN51_11935	COG0697	spore germination
BRN51_11945	COG1794	racemase activity, acting on amino acids and derivatives
BRN51_11970	COG0671	phosphoesterase, PA-phosphatase related
BRN51_11985	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BRN51_12000	COG2183	response to ionizing radiation
BRN51_12010	COG0723	plastoquinol--plastocyanin reductase activity
BRN51_12010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN51_12025	COG3243	poly(R)-hydroxyalkanoic acid synthase
BRN51_12035	COG1183	phosphatidylcholine synthase activity
BRN51_12040	COG1028	Short-chain dehydrogenase reductase Sdr
BRN51_12055	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BRN51_12065	COG0668	transmembrane transport
BRN51_12075	COG0590	tRNA wobble adenosine to inosine editing
BRN51_12080	COG1321	iron dependent repressor
BRN51_12085	COG1914	H( )-stimulated, divalent metal cation uptake system
BRN51_12145	COG0583	DNA-binding transcription factor activity
BRN51_12150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRN51_12160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRN51_12160	COG0519	Catalyzes the synthesis of GMP from XMP
BRN51_12190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BRN51_12200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRN51_12205	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BRN51_12220	COG0539	negative regulation of cytoplasmic translation
BRN51_12230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BRN51_12240	COG2957	Belongs to the agmatine deiminase family
BRN51_12250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRN51_12275	COG0395	ABC-type sugar transport system, permease component
BRN51_12280	COG1175	transmembrane transport
BRN51_12310	COG2350	Protein conserved in bacteria
BRN51_12315	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BRN51_12320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BRN51_12325	COG1187	pseudouridine synthase activity
BRN51_12350	COG0436	Aminotransferase
BRN51_12415	COG0277	FAD linked oxidase domain protein
BRN51_12420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BRN51_12430	COG0531	amino acid
BRN51_12435	COG0531	amino acid
BRN51_12440	COG0235	Class ii aldolase
BRN51_12450	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BRN51_12480	COG3039	Transposase
BRN51_12490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BRN51_12570	COG0303	'Molybdopterin
BRN51_12580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN51_12590	COG1426	Protein conserved in bacteria
BRN51_12605	COG0105	UTP biosynthetic process
BRN51_12615	COG1024	Enoyl-CoA hydratase
BRN51_12615	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRN51_12620	COG0183	Belongs to the thiolase family
BRN51_12625	COG0038	chloride channel
BRN51_12645	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BRN51_12670	COG1674	ftsk spoiiie
BRN51_12675	COG0492	ferredoxin-NADP+ reductase activity
BRN51_12695	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BRN51_12700	COG0542	response to heat
BRN51_12705	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BRN51_12715	COG0482	sulfurtransferase activity
BRN51_12740	COG5001	Diguanylate cyclase
BRN51_12745	COG4585	Histidine kinase
BRN51_12755	COG5002	protein histidine kinase activity
BRN51_12775	COG0784	Response regulator, receiver
BRN51_12775	COG0835	chemotaxis
BRN51_12785	COG1558	bacterial-type flagellum-dependent cell motility
BRN51_12790	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BRN51_12795	COG1749	Flagellar hook protein flgE
BRN51_12800	COG4787	bacterial-type flagellum-dependent cell motility
BRN51_12810	COG4786	Flagellar basal body rod
BRN51_12840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BRN51_12845	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BRN51_12875	COG2201	protein-glutamate methylesterase activity
BRN51_12880	COG2204	response regulator
BRN51_12895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRN51_12905	COG1028	Short-chain dehydrogenase reductase Sdr
BRN51_12940	COG1677	Flagellar hook-basal body complex protein FliE
BRN51_12990	COG3190	flagellar
BRN51_13005	COG1987	bacterial-type flagellum assembly
BRN51_13010	COG1684	flagellar biosynthetic protein fliR
BRN51_13015	COG5001	Diguanylate cyclase
BRN51_13015	COG3300	MHYT domain
BRN51_13020	COG5001	Diguanylate cyclase
BRN51_13020	COG3300	MHYT domain
BRN51_13035	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BRN51_13045	COG0455	bacterial-type flagellum organization
BRN51_13065	COG2198	Histidine kinase
BRN51_13065	COG0643	Histidine kinase
BRN51_13195	COG0583	DNA-binding transcription factor activity
BRN51_13205	COG3039	Transposase
BRN51_13300	COG1278	Cold shock
BRN51_13310	COG3328	transposase activity
BRN51_13350	COG3039	Transposase
BRN51_13365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRN51_13380	COG0557	exoribonuclease II activity
BRN51_13410	COG1960	acyl-CoA dehydrogenase activity
BRN51_13420	COG1410	methionine synthase
BRN51_13420	COG0646	methionine synthase
BRN51_13425	COG0646	methionine synthase
BRN51_13425	COG1410	methionine synthase
BRN51_13435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN51_13475	COG0386	Belongs to the glutathione peroxidase family
BRN51_13485	COG1725	Transcriptional regulator
BRN51_13490	COG1131	(ABC) transporter
BRN51_13570	COG2850	peptidyl-arginine hydroxylation
BRN51_13605	COG1132	(ABC) transporter
BRN51_13620	COG0583	DNA-binding transcription factor activity
BRN51_13640	COG1605	Chorismate mutase
BRN51_13640	COG0287	Prephenate dehydrogenase
BRN51_13645	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BRN51_13675	COG0497	DNA recombination
BRN51_13685	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN51_13695	COG2914	Belongs to the UPF0125 (RnfH) family
BRN51_13705	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BRN51_13720	COG1960	acyl-CoA dehydrogenase activity
BRN51_13775	COG2814	Major facilitator Superfamily
BRN51_13780	COG1566	PFAM secretion protein HlyD family protein
BRN51_13795	COG2207	Transcriptional regulator
BRN51_13830	COG4774	siderophore transport
BRN51_13845	COG0367	asparagine synthase
BRN51_13850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRN51_13860	COG1393	Belongs to the ArsC family
BRN51_13880	COG0024	Methionine aminopeptidase
BRN51_13945	COG0575	Belongs to the CDS family
BRN51_13950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BRN51_13955	COG0750	zinc metalloprotease
BRN51_14015	COG4771	TonB-dependent receptor
BRN51_14020	COG1131	(ABC) transporter
BRN51_14090	COG0529	Catalyzes the synthesis of activated sulfate
BRN51_14090	COG2895	sulfate adenylyltransferase (ATP) activity
BRN51_14130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRN51_14150	COG2040	homocysteine
BRN51_14155	COG0833	amino acid
BRN51_14185	COG2878	Part of a membrane complex involved in electron transport
BRN51_14205	COG1595	DNA-templated transcription, initiation
BRN51_14230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRN51_14245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRN51_14250	COG0251	oxidation-reduction process
BRN51_14260	COG0392	lysyltransferase activity
BRN51_14260	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BRN51_14305	COG2814	Major facilitator Superfamily
BRN51_14310	COG1902	pentaerythritol trinitrate reductase activity
BRN51_14325	COG2824	Alkylphosphonate utilization operon protein PhnA
BRN51_14340	COG1047	Peptidyl-prolyl cis-trans
BRN51_14375	COG3039	Transposase
BRN51_14380	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BRN51_14395	COG1451	nucleotide metabolic process
BRN51_14420	COG0183	Belongs to the thiolase family
BRN51_14435	COG0745	RESPONSE REGULATOR receiver
BRN51_14435	COG3706	GGDEF domain
BRN51_14450	COG1793	dna ligase
BRN51_14450	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BRN51_14460	COG1793	dna ligase
BRN51_14465	COG1201	RNA secondary structure unwinding
BRN51_14485	COG1278	Cold shock
BRN51_14490	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BRN51_14505	COG3046	protein related to deoxyribodipyrimidine photolyase
BRN51_14510	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BRN51_14575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRN51_14590	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRN51_14590	COG1024	Enoyl-CoA hydratase
BRN51_14610	COG1024	Enoyl-CoA hydratase
BRN51_14615	COG1960	acyl-CoA dehydrogenase activity
BRN51_14680	COG2353	YceI-like domain
BRN51_14690	COG2353	YceI-like domain
BRN51_14705	COG1760	l-serine dehydratase
BRN51_14715	COG0626	cystathionine gamma-synthase activity
BRN51_14720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN51_14725	COG0739	heme binding
BRN51_14730	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BRN51_14735	COG1272	protein, Hemolysin III
BRN51_14760	COG0463	Glycosyl transferase, family 2
BRN51_14770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BRN51_14780	COG4771	TonB-dependent receptor
BRN51_14785	COG1309	transcriptional regulator
BRN51_14795	COG1960	acyl-CoA dehydrogenase activity
BRN51_14835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BRN51_14845	COG0330	HflC and HflK could
BRN51_14860	COG3956	TIGRFAM MazG family protein
BRN51_14870	COG0494	nUDIX hydrolase
BRN51_14880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BRN51_14885	COG0837	glucose binding
BRN51_14900	COG1388	LysM domain
BRN51_14900	COG3858	chitin binding
BRN51_14920	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN51_14985	COG3537	Alpha-1,2-mannosidase
BRN51_15030	COG3142	Participates in the control of copper homeostasis
BRN51_15035	COG1446	asparaginase
BRN51_15095	COG0840	transmembrane signaling receptor activity
BRN51_15100	COG0835	chemotaxis
BRN51_15115	COG0189	ligase activity
BRN51_15125	COG1397	ADP-ribosylglycohydrolase
BRN51_15135	COG1199	ATP-dependent helicase activity
BRN51_15145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BRN51_15160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRN51_15175	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BRN51_15180	COG0535	radical SAM domain protein
BRN51_15185	COG0535	radical SAM domain protein
BRN51_15210	COG1643	Atp-dependent helicase
BRN51_15215	COG0783	Belongs to the Dps family
BRN51_15225	COG0514	ATP-dependent DNA helicase (RecQ)
BRN51_15275	COG0602	queuosine metabolic process
BRN51_15285	COG2885	chlorophyll binding
BRN51_15290	COG0823	Involved in the tonB-independent uptake of proteins
BRN51_15300	COG0848	biopolymer transport protein
BRN51_15310	COG0824	Thioesterase
BRN51_15330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BRN51_15335	COG0217	transcriptional regulatory protein
BRN51_15350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BRN51_15365	COG0477	Major facilitator Superfamily
BRN51_15445	COG3501	Rhs element vgr protein
BRN51_15475	COG0316	Belongs to the HesB IscA family
BRN51_15475	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BRN51_15480	COG2154	pterin-4-alpha-carbinolamine dehydratase
BRN51_15490	COG0428	transporter
BRN51_15495	COG0428	transporter
BRN51_15500	COG3064	Membrane
BRN51_15510	COG1530	ribonuclease E activity
BRN51_15550	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BRN51_15610	COG3039	Transposase
BRN51_15615	COG3039	Transposase
BRN51_15660	COG1648	precorrin-2 dehydrogenase activity
BRN51_15660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BRN51_15685	COG0746	molybdenum cofactor guanylyltransferase activity
BRN51_15770	COG4206	TonB-dependent receptor
BRN51_15820	COG0531	amino acid
BRN51_15835	COG0006	proline dipeptidase activity
BRN51_15845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRN51_15860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN51_15865	COG3938	Belongs to the proline racemase family
BRN51_15875	COG0552	protein localization to endoplasmic reticulum
BRN51_15900	COG4191	Histidine kinase
BRN51_15900	COG0784	Response regulator, receiver
BRN51_15995	COG3040	lipid binding
BRN51_16045	COG0438	transferase activity, transferring glycosyl groups
BRN51_16050	COG0438	transferase activity, transferring glycosyl groups
BRN51_16095	COG0776	regulation of translation
BRN51_16105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BRN51_16110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BRN51_16115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BRN51_16120	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BRN51_16160	COG0556	nucleotide-excision repair
BRN51_16165	COG4969	Belongs to the N-Me-Phe pilin family
BRN51_16180	COG3039	Transposase
BRN51_16220	COG4695	Portal protein
BRN51_16265	COG3179	chitinase
BRN51_16480	COG1611	Belongs to the LOG family
BRN51_16495	COG2095	MarC family integral membrane protein
BRN51_16505	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRN51_16510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRN51_16545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BRN51_16560	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BRN51_16565	COG0195	Participates in both transcription termination and antitermination
BRN51_16580	COG1007	ATP synthesis coupled electron transport
BRN51_16595	COG0713	ATP synthesis coupled electron transport
BRN51_16610	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BRN51_16615	COG1034	ATP synthesis coupled electron transport
BRN51_16620	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BRN51_16625	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BRN51_16645	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRN51_16665	COG1028	Short-chain dehydrogenase reductase Sdr
BRN51_16725	COG0159	tryptophan synthase activity
BRN51_16735	COG0133	tryptophan synthase activity
BRN51_16770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BRN51_16775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BRN51_16785	COG2890	protein-(glutamine-N5) methyltransferase activity
BRN51_16850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN51_16860	COG0412	Dienelactone hydrolase
BRN51_16885	COG0489	protein tyrosine kinase activity
BRN51_16930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN51_16935	COG2311	Membrane
BRN51_16940	COG1047	Peptidyl-prolyl cis-trans
BRN51_16945	COG0791	NLP P60 protein
BRN51_16950	COG0791	NLP P60 protein
BRN51_16965	COG1301	dicarboxylic acid transport
BRN51_16970	COG1785	Belongs to the alkaline phosphatase family
BRN51_16975	COG0037	tRNA processing
BRN51_16985	COG0142	geranyltranstransferase activity
BRN51_17010	COG0312	modulator of DNA gyrase
BRN51_17015	COG3028	Belongs to the UPF0307 family
BRN51_17020	COG0312	modulator of DNA gyrase
BRN51_17030	COG3164	Protein of unknown function
BRN51_17035	COG1530	ribonuclease E activity
BRN51_17045	COG2968	Membrane
BRN51_17100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BRN51_17120	COG0495	leucyl-tRNA aminoacylation
BRN51_17130	COG3118	belongs to the thioredoxin family
BRN51_17195	COG3039	Transposase
BRN51_17215	COG3039	Transposase
BRN51_17325	COG3273	potassium ion transport
BRN51_17325	COG0471	metal ion transport
BRN51_17355	COG1970	mechanosensitive ion channel activity
BRN51_17380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRN51_17410	COG0308	aminopeptidase N
BRN51_17415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN51_17430	COG3039	Transposase
BRN51_17445	COG2895	sulfate adenylyltransferase (ATP) activity
BRN51_17445	COG0529	Catalyzes the synthesis of activated sulfate
BRN51_17455	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRN51_17490	COG2198	Histidine kinase
BRN51_17490	COG0784	Response regulator, receiver
BRN51_17490	COG2205	protein histidine kinase activity
BRN51_17540	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BRN51_17545	COG3588	fructose-bisphosphate aldolase
BRN51_17555	COG0469	pyruvate kinase activity
BRN51_17565	COG0126	phosphoglycerate kinase activity
BRN51_17600	COG0753	catalase activity
BRN51_17625	COG2207	Transcriptional regulator
BRN51_17625	COG1917	Cupin 2, conserved barrel domain protein
BRN51_17645	COG0823	Involved in the tonB-independent uptake of proteins
BRN51_17645	COG1506	peptidase
BRN51_17670	COG1297	OPT oligopeptide transporter protein
BRN51_17690	COG0587	DNA-directed DNA polymerase activity
BRN51_17740	COG0328	RNA-DNA hybrid ribonuclease activity
BRN51_17740	COG0406	alpha-ribazole phosphatase activity
BRN51_17820	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BRN51_17965	COG3501	Rhs element vgr protein
BRN51_17970	COG3179	chitinase
BRN51_17975	COG3501	Rhs element vgr protein
BRN51_18020	COG3501	Rhs element vgr protein
BRN51_18030	COG1741	Belongs to the pirin family
BRN51_18035	COG1966	Carbon starvation protein
BRN51_18040	COG2879	small protein
BRN51_18075	COG3706	GGDEF domain
BRN51_18075	COG5001	Diguanylate cyclase
BRN51_18075	COG2203	Gaf domain
BRN51_18075	COG4251	negative regulation of phosphorylation
BRN51_18085	COG0629	single-stranded DNA binding
BRN51_18090	COG0142	geranyltranstransferase activity
BRN51_18120	COG0527	aspartate kinase activity
BRN51_18130	COG0384	phenazine biosynthesis protein PhzF
BRN51_18140	COG1764	response to oxidative stress
BRN51_18170	COG0519	Catalyzes the synthesis of GMP from XMP
BRN51_18205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BRN51_18250	COG0693	protein deglycase activity
BRN51_18270	COG1959	2 iron, 2 sulfur cluster binding
BRN51_18275	COG0719	Fe-S assembly protein
BRN51_18280	COG0396	ATPase activity
BRN51_18285	COG0719	Fe-S assembly protein
BRN51_18290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BRN51_18350	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BRN51_18360	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BRN51_18365	COG0174	glutamine synthetase
BRN51_18400	COG0326	Molecular chaperone. Has ATPase activity
BRN51_18405	COG2207	Transcriptional regulator
BRN51_18425	COG0657	acetylesterase activity
BRN51_18425	COG2755	lipolytic protein G-D-S-L family
BRN51_18450	COG0488	(ABC) transporter
BRN51_18485	COG4651	solute:proton antiporter activity
BRN51_18485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BRN51_18500	COG4772	TonB-dependent receptor
BRN51_18510	COG4264	IucA IucC family
BRN51_18515	COG2814	Major facilitator Superfamily
BRN51_18525	COG0019	diaminopimelate decarboxylase activity
BRN51_18545	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BRN51_18585	COG4206	TonB-dependent receptor
BRN51_18625	COG0542	response to heat
BRN51_18670	COG0534	Mate efflux family protein
BRN51_18720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BRN51_18735	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRN51_18785	COG1555	photosystem II stabilization
BRN51_18790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRN51_18805	COG3178	'Phosphotransferase
BRN51_18810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BRN51_18820	COG0628	permease
BRN51_18845	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BRN51_18870	COG0271	Belongs to the BolA IbaG family
BRN51_18880	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BRN51_18890	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BRN51_18895	COG1137	ATPase activity
BRN51_18910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN51_18930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN51_18935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRN51_18945	COG2239	Acts as a magnesium transporter
BRN51_18955	COG1294	oxidase, subunit
BRN51_18960	COG1271	oxidase subunit
BRN51_18980	COG1113	amino acid transport
BRN51_18995	COG2197	response regulator
BRN51_19000	COG0531	amino acid
BRN51_19055	COG0789	Transcriptional regulator
BRN51_19070	COG0754	glutathionylspermidine amidase activity
BRN51_19095	COG1842	Phage shock protein A
BRN51_19115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BRN51_19125	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BRN51_19160	COG2201	protein-glutamate methylesterase activity
BRN51_19180	COG2201	protein-glutamate methylesterase activity
BRN51_19210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BRN51_19255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRN51_19260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRN51_19285	COG3039	Transposase
BRN51_19300	COG0745	RESPONSE REGULATOR receiver
BRN51_19305	COG3039	Transposase
BRN51_19310	COG2205	protein histidine kinase activity
BRN51_19330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BRN51_19375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRN51_19375	COG3453	Protein conserved in bacteria
BRN51_19380	COG0725	ABC transporter, periplasmic molybdate-binding protein
BRN51_19385	COG4149	molybdate abc transporter
BRN51_19390	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BRN51_19410	COG0642	Histidine kinase
BRN51_19415	COG0745	RESPONSE REGULATOR receiver
BRN51_19425	COG1028	Short-chain dehydrogenase reductase Sdr
BRN51_19435	COG1022	Amp-dependent synthetase and ligase
BRN51_19460	COG1376	ErfK ybiS ycfS ynhG family protein
BRN51_19465	COG0739	heme binding
BRN51_19475	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BRN51_19480	COG1301	dicarboxylic acid transport
BRN51_19500	COG2304	oxidoreductase activity
BRN51_19520	COG0714	Associated with various cellular activities
BRN51_19560	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BRN51_19575	COG0254	rRNA binding
BRN51_19585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BRN51_19595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRN51_19620	COG1561	YicC-like family, N-terminal region
BRN51_19640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BRN51_19670	COG0006	proline dipeptidase activity
BRN51_19695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BRN51_19705	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BRN51_19715	COG2912	Transglutaminase-like superfamily
BRN51_19720	COG1773	rubredoxin
BRN51_19725	COG0352	thiamine-phosphate diphosphorylase activity
BRN51_19760	COG0281	malic enzyme
BRN51_19760	COG0280	phosphate acetyltransferase
BRN51_19780	COG4191	Histidine kinase
BRN51_19795	COG0583	DNA-binding transcription factor activity
BRN51_19820	COG2197	response regulator
BRN51_19825	COG1840	ABC-type Fe3 transport system, periplasmic component
BRN51_19830	COG0642	Histidine kinase
BRN51_19850	COG2851	Citrate transporter
BRN51_19855	COG1028	Short-chain dehydrogenase reductase Sdr
BRN51_19860	COG1609	Transcriptional regulator
BRN51_19870	COG2211	Major facilitator Superfamily
BRN51_19895	COG1162	GTPase activity
BRN51_19920	COG0726	polysaccharide deacetylase
BRN51_19925	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRN51_19975	COG0242	peptide deformylase activity
BRN51_19995	COG0714	Associated with various cellular activities
BRN51_20015	COG0537	adenosine 5'-monophosphoramidase activity
BRN51_20045	COG0314	molybdopterin synthase activity
BRN51_20050	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BRN51_20065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BRN51_20070	COG1234	tRNA 3'-trailer cleavage
BRN51_20080	COG0859	PFAM glycosyl transferase family 9
BRN51_20090	COG0582	viral genome integration into host DNA
BRN51_20135	COG3501	Rhs element vgr protein
BRN51_20165	COG0631	protein serine/threonine phosphatase activity
BRN51_20175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRN51_20200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BRN51_20230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BRN51_20235	COG0740	serine-type endopeptidase activity
BRN51_20240	COG0544	peptidyl-prolyl cis-trans isomerase activity
BRN51_20295	COG0473	3-isopropylmalate dehydrogenase activity
BRN51_20320	COG4783	chaperone-mediated protein folding
BRN51_20335	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BRN51_20345	COG0438	transferase activity, transferring glycosyl groups
BRN51_20350	COG0671	phosphoesterase, PA-phosphatase related
BRN51_20380	COG2833	Protein of unknown function (DUF455)
BRN51_20400	COG0285	dihydrofolate synthase activity
BRN51_20410	COG0406	alpha-ribazole phosphatase activity
BRN51_20445	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BRN51_20450	COG4208	sulfate ABC transporter
BRN51_20455	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BRN51_20460	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BRN51_20465	COG0156	8-amino-7-oxononanoate synthase activity
BRN51_20500	COG1902	pentaerythritol trinitrate reductase activity
BRN51_20500	COG0446	pyridine nucleotide-disulphide oxidoreductase
BRN51_20530	COG0584	glycerophosphoryl diester phosphodiesterase
BRN51_20560	COG3039	Transposase
BRN51_20580	COG0625	glutathione transferase activity
BRN51_20585	COG0039	L-malate dehydrogenase activity
BRN51_20590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BRN51_20615	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BRN51_20770	COG3781	membrane
BRN51_20780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRN51_20810	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BRN51_20830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BRN51_20855	COG3710	Transcriptional regulator
BRN51_20900	COG2226	methyltransferase
BRN51_20940	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRN51_20945	COG1538	Outer membrane efflux protein
BRN51_20950	COG1519	Transferase
BRN51_20955	COG1560	Kdo2-lipid A biosynthetic process
BRN51_21005	COG0308	aminopeptidase N
BRN51_21010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BRN51_21020	COG0330	HflC and HflK could
BRN51_21025	COG0330	HflC and HflK could
BRN51_21045	COG0678	peroxiredoxin activity
BRN51_21055	COG2826	transposase and inactivated derivatives, IS30 family
BRN51_21170	COG3829	transcription factor binding
BRN51_21195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BRN51_21200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BRN51_21215	COG1028	Short-chain dehydrogenase reductase Sdr
BRN51_21240	COG1399	metal-binding, possibly nucleic acid-binding protein
BRN51_21285	COG1518	maintenance of DNA repeat elements
BRN51_21290	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BRN51_21345	COG2188	Transcriptional regulator
BRN51_21360	COG1450	Type ii and iii secretion system protein
BRN51_21375	COG3166	PFAM Fimbrial assembly family protein
BRN51_21380	COG3156	type II secretion system protein K
BRN51_21385	COG4795	General secretion pathway protein
BRN51_21390	COG2165	general secretion pathway protein
BRN51_21395	COG4970	Tfp pilus assembly protein FimT
BRN51_21400	COG2165	general secretion pathway protein
BRN51_21405	COG1459	type II secretion system
BRN51_21415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRN51_21425	COG5295	Hep Hag repeat protein
BRN51_21435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BRN51_21435	COG0047	phosphoribosylformylglycinamidine synthase activity
BRN51_21440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BRN51_21445	COG4974	Belongs to the 'phage' integrase family
BRN51_21460	COG0795	lipopolysaccharide-transporting ATPase activity
BRN51_21485	COG0525	valine-tRNA ligase activity
BRN51_21515	COG3039	Transposase
BRN51_21550	COG3039	Transposase
BRN51_21585	COG1183	phosphatidylcholine synthase activity
BRN51_21610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRN51_21615	COG1127	ABC transporter
BRN51_21620	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRN51_21620	COG3218	ABC-type transport auxiliary lipoprotein component
BRN51_21660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRN51_21665	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BRN51_21665	COG0662	Cupin 2, conserved barrel domain protein
BRN51_21690	COG2086	electron transfer activity
BRN51_21715	COG3328	transposase activity
BRN51_21765	COG0626	cystathionine gamma-synthase activity
BRN51_21795	COG0625	glutathione transferase activity
BRN51_21810	COG0513	Belongs to the DEAD box helicase family
BRN51_21820	COG0720	synthase
BRN51_21835	COG1956	GAF domain-containing protein
BRN51_21875	COG0339	signal peptide processing
BRN51_21925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRN51_21930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN51_21985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BRN51_22005	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BRN51_22020	COG0356	it plays a direct role in the translocation of protons across the membrane
BRN51_22040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRN51_22050	COG0508	dehydrogenase complex catalyzes the overall conversion of
BRN51_22080	COG2011	ABC-type metal ion transport system permease component
BRN51_22090	COG0697	spore germination
BRN51_22130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BRN51_22135	COG1187	pseudouridine synthase activity
BRN51_22140	COG2813	Specifically methylates the guanine in position
BRN51_22170	COG2202	Pas domain
BRN51_22170	COG2205	protein histidine kinase activity
BRN51_22195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN51_22200	COG1522	sequence-specific DNA binding
BRN51_22245	COG0745	RESPONSE REGULATOR receiver
BRN51_22260	COG1404	Belongs to the peptidase S8 family
BRN51_22275	COG0842	Transport permease protein
BRN51_22280	COG1131	(ABC) transporter
BRN51_22285	COG0025	NhaP-type Na H and K H
BRN51_22300	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BRN51_22310	COG1573	uracil-dna glycosylase
BRN51_22320	COG3384	dioxygenase
BRN51_22335	COG0667	Aldo Keto reductase
BRN51_22350	COG3590	peptidase
BRN51_22370	COG0531	amino acid
BRN51_22385	COG2972	Histidine kinase
BRN51_22455	COG1271	oxidase subunit
BRN51_22490	COG1324	tolerance protein
BRN51_22515	COG0511	ligase activity, forming carbon-carbon bonds
BRN51_22525	COG0439	Biotin carboxylase
BRN51_22585	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BRN51_22715	COG2831	hemolysin activation secretion protein
BRN51_22740	COG2453	phosphatase
BRN51_22740	COG0671	phosphoesterase, PA-phosphatase related
BRN51_22745	COG2267	carboxylic ester hydrolase activity
BRN51_22755	COG2267	carboxylic ester hydrolase activity
BRN51_22765	COG0138	bifunctional purine biosynthesis protein purh
BRN51_22770	COG0151	Belongs to the GarS family
BRN51_22775	COG1136	(ABC) transporter
BRN51_22775	COG0577	efflux transmembrane transporter activity
BRN51_22785	COG1289	transmembrane transporter activity
BRN51_22800	COG2814	Major facilitator Superfamily
BRN51_22825	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BRN51_22905	COG0739	heme binding
BRN51_22920	COG2211	Major facilitator Superfamily
BRN51_22925	COG0708	Exodeoxyribonuclease III
BRN51_22940	COG1192	Involved in chromosome partitioning
BRN51_22945	COG1475	DNA binding
BRN51_22960	COG0463	Glycosyl transferase, family 2
BRN51_22980	COG0756	dUTP diphosphatase activity
BRN51_22985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BRN51_22990	COG2003	Belongs to the UPF0758 family
BRN51_22995	COG0018	arginyl-trna synthetase
BRN51_23010	COG4221	oxidoreductase activity
BRN51_23035	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BRN51_23040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN51_23055	COG3485	protocatechuate 3,4-dioxygenase
BRN51_23060	COG3485	protocatechuate 3,4-dioxygenase
BRN51_23100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRN51_23110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRN51_23125	COG0045	succinate-CoA ligase (ADP-forming) activity
BRN51_23125	COG1042	CoA-binding domain protein
BRN51_23125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BRN51_23135	COG2239	Acts as a magnesium transporter
BRN51_23150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRN51_23155	COG3387	PFAM Glycoside hydrolase 15-related
BRN51_23170	COG3100	YcgL domain-containing protein
BRN51_23175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRN51_23185	COG0463	Glycosyl transferase, family 2
BRN51_23200	COG1028	Short-chain dehydrogenase reductase Sdr
BRN51_23225	COG1040	competence protein
BRN51_23245	COG0628	permease
BRN51_23255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRN51_23265	COG1595	DNA-templated transcription, initiation
BRN51_23270	COG0753	catalase activity
BRN51_23315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRN51_23320	COG0180	Tryptophanyl-tRNA synthetase
BRN51_23325	COG3237	CsbD-like
BRN51_23385	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BRN51_23385	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BRN51_23410	COG2205	protein histidine kinase activity
BRN51_23415	COG0745	RESPONSE REGULATOR receiver
BRN51_23425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRN51_23455	COG1566	PFAM secretion protein HlyD family protein
BRN51_23475	COG1199	ATP-dependent helicase activity
BRN51_23510	COG0583	DNA-binding transcription factor activity
BRN51_23560	COG0625	glutathione transferase activity
BRN51_23595	COG4555	ABC transporter
BRN51_23605	COG1476	TRANSCRIPTIONal
BRN51_23625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRN51_23630	COG1131	(ABC) transporter
BRN51_23635	COG0842	Transport permease protein
BRN51_23645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BRN51_23730	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRN51_23755	COG0564	pseudouridine synthase activity
BRN51_23785	COG0339	signal peptide processing
BRN51_23815	COG3254	rhamnose metabolic process
BRN51_23820	COG0738	Major facilitator superfamily
BRN51_23825	COG1414	Transcriptional regulator
BRN51_23840	COG2205	protein histidine kinase activity
BRN51_23855	COG3459	Glycosyltransferase 36 associated
BRN51_23860	COG2211	Major facilitator Superfamily
BRN51_23865	COG3265	gluconokinase activity
BRN51_23875	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN51_23955	COG1127	ABC transporter
BRN51_23960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRN51_23965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRN51_23980	COG2853	Lipoprotein
BRN51_24070	COG0676	glucose-6-phosphate 1-epimerase activity
BRN51_24095	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN51_24105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN51_24115	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN51_24125	COG1064	alcohol dehydrogenase
BRN51_24170	COG1522	sequence-specific DNA binding
BRN51_24175	COG3186	Phenylalanine-4-hydroxylase
BRN51_24190	COG2755	lipolytic protein G-D-S-L family
BRN51_24215	COG0656	L-ascorbic acid biosynthetic process
BRN51_24220	COG2130	NADP-dependent
BRN51_24225	COG0667	Aldo Keto reductase
BRN51_24235	COG1187	pseudouridine synthase activity
BRN51_24250	COG1643	Atp-dependent helicase
BRN51_24255	COG4807	Protein conserved in bacteria
BRN51_24260	COG4948	Mandelate Racemase Muconate Lactonizing
BRN51_24270	COG0179	Fumarylacetoacetate (FAA) hydrolase
BRN51_24275	COG1028	Short-chain dehydrogenase reductase Sdr
BRN51_24295	COG3507	Belongs to the glycosyl hydrolase 43 family
BRN51_24340	COG3162	membrane
BRN51_24345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BRN51_24360	COG0708	Exodeoxyribonuclease III
BRN51_24375	COG2091	lysine biosynthetic process via aminoadipic acid
BRN51_24385	COG3540	Alkaline phosphatase
BRN51_24390	COG0357	Ribosomal RNA small subunit methyltransferase G
BRN51_24405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BRN51_24410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BRN51_24415	COG2159	amidohydrolase
BRN51_24430	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRN51_24435	COG0583	DNA-binding transcription factor activity
BRN51_24440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN51_24460	COG0210	DNA helicase
BRN51_24475	COG0531	amino acid
BRN51_24485	COG1322	Protein conserved in bacteria
BRN51_24495	COG0386	Belongs to the glutathione peroxidase family
BRN51_24550	COG0793	Belongs to the peptidase S41A family
BRN51_24555	COG4942	peptidase
BRN51_24565	COG2234	aminopeptidase activity
BRN51_24615	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRN51_24620	COG0302	gtp cyclohydrolase
BRN51_24640	COG0477	Major facilitator Superfamily
BRN51_24655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN51_24770	COG1929	Belongs to the glycerate kinase type-1 family
BRN51_24775	COG2271	Major facilitator Superfamily
BRN51_24790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRN51_24800	COG0861	Integral membrane protein TerC family
BRN51_24810	COG0584	glycerophosphoryl diester phosphodiesterase
BRN51_24820	COG0671	phosphoesterase, PA-phosphatase related
BRN51_24825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BRN51_24830	COG0726	polysaccharide deacetylase
BRN51_24835	COG0706	membrane insertase activity
BRN51_24845	COG0230	Belongs to the bacterial ribosomal protein bL34 family