locus-tag	class	description
BRN52_00025	COG0187	DNA topoisomerase II activity
BRN52_00035	COG0501	Belongs to the peptidase M48B family
BRN52_00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BRN52_00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN52_00095	COG4772	TonB-dependent receptor
BRN52_00110	COG3039	Transposase
BRN52_00120	COG1755	Isoprenylcysteine carboxyl methyltransferase
BRN52_00135	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BRN52_00145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN52_00250	COG2826	transposase and inactivated derivatives, IS30 family
BRN52_00275	COG3039	Transposase
BRN52_00285	COG1090	epimerase
BRN52_00295	COG0642	Histidine kinase
BRN52_00305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRN52_00415	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BRN52_00500	COG1511	domain protein
BRN52_00500	COG3264	Mechanosensitive ion channel
BRN52_00515	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRN52_00525	COG2354	Protein conserved in bacteria
BRN52_00535	COG0745	RESPONSE REGULATOR receiver
BRN52_00535	COG3706	GGDEF domain
BRN52_00550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BRN52_00575	COG0702	epimerase
BRN52_00585	COG1858	cytochrome C peroxidase
BRN52_00670	COG0513	Belongs to the DEAD box helicase family
BRN52_00680	COG3039	Transposase
BRN52_00730	COG1136	(ABC) transporter
BRN52_00765	COG1136	(ABC) transporter
BRN52_00810	COG1272	protein, Hemolysin III
BRN52_00815	COG1111	helicase
BRN52_00815	COG1205	dead DEAH box helicase
BRN52_00875	COG0070	glutamate synthase
BRN52_00875	COG0069	glutamate synthase activity
BRN52_00875	COG0067	glutamate synthase
BRN52_00880	COG0493	'glutamate synthase
BRN52_00925	COG1609	Transcriptional regulator
BRN52_00960	COG0366	Alpha amylase catalytic
BRN52_00965	COG0366	Alpha amylase catalytic
BRN52_01030	COG0606	chelatase, subunit chli
BRN52_01085	COG1166	arginine decarboxylase activity
BRN52_01095	COG3501	Rhs element vgr protein
BRN52_01160	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_01185	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BRN52_01200	COG0210	DNA helicase
BRN52_01220	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BRN52_01260	COG2937	Belongs to the GPAT DAPAT family
BRN52_01285	COG3328	transposase activity
BRN52_01335	COG1752	Esterase of the alpha-beta hydrolase superfamily
BRN52_01345	COG1119	ATPase activity
BRN52_01360	COG0517	IMP dehydrogenase activity
BRN52_01360	COG1125	glycine betaine transport
BRN52_01375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN52_01380	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BRN52_01385	COG3550	peptidyl-serine autophosphorylation
BRN52_01390	COG1396	sequence-specific DNA binding
BRN52_01410	COG0489	protein tyrosine kinase activity
BRN52_01415	COG2062	phosphohistidine phosphatase, SixA
BRN52_01425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN52_01475	COG0174	glutamine synthetase
BRN52_01480	COG0347	Belongs to the P(II) protein family
BRN52_01485	COG0004	ammonium transporteR
BRN52_01490	COG3852	Histidine kinase
BRN52_01495	COG2204	response regulator
BRN52_01500	COG2032	superoxide dismutase activity
BRN52_01505	COG2032	superoxide dismutase activity
BRN52_01555	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BRN52_01560	COG1074	ATP-dependent DNA helicase activity
BRN52_01570	COG3549	Plasmid maintenance system killer
BRN52_01660	COG1764	response to oxidative stress
BRN52_01665	COG1846	Transcriptional regulator
BRN52_01715	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BRN52_01755	COG2211	Major facilitator Superfamily
BRN52_01780	COG3693	PFAM glycoside hydrolase, family 10
BRN52_01805	COG0246	Mannitol dehydrogenase
BRN52_01810	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN52_01820	COG4948	Mandelate Racemase Muconate Lactonizing
BRN52_01830	COG3661	Belongs to the glycosyl hydrolase 67 family
BRN52_01850	COG0037	tRNA processing
BRN52_01855	COG2974	May be involved in recombination
BRN52_01885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BRN52_01895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BRN52_01905	COG0805	protein transport
BRN52_01915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRN52_01915	COG0519	Catalyzes the synthesis of GMP from XMP
BRN52_01940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRN52_01945	COG0752	glycyl-tRNA synthetase alpha subunit
BRN52_01955	COG0457	Tetratricopeptide repeat
BRN52_01960	COG4771	TonB-dependent receptor
BRN52_01975	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BRN52_01985	COG0697	spore germination
BRN52_01995	COG0523	cobalamin synthesis protein
BRN52_02050	COG1960	acyl-CoA dehydrogenase activity
BRN52_02055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BRN52_02145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRN52_02190	COG0084	hydrolase, TatD family'
BRN52_02210	COG0583	DNA-binding transcription factor activity
BRN52_02215	COG2814	Major facilitator Superfamily
BRN52_02225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BRN52_02230	COG1902	pentaerythritol trinitrate reductase activity
BRN52_02260	COG0745	RESPONSE REGULATOR receiver
BRN52_02280	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRN52_02285	COG0583	DNA-binding transcription factor activity
BRN52_02320	COG0702	epimerase
BRN52_02325	COG1733	regulation of RNA biosynthetic process
BRN52_02395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRN52_02410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRN52_02445	COG2911	Protein conserved in bacteria
BRN52_02450	COG0729	surface antigen
BRN52_02465	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BRN52_02470	COG3118	belongs to the thioredoxin family
BRN52_02480	COG2884	Cell division ATP-binding protein ftsE
BRN52_02485	COG2177	Part of the ABC transporter FtsEX involved in
BRN52_02490	COG3437	response regulator, receiver
BRN52_02500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRN52_02510	COG1252	NADH dehydrogenase
BRN52_02530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BRN52_02545	COG4771	TonB-dependent receptor
BRN52_02560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BRN52_02600	COG3386	PFAM SMP-30 Gluconolaconase
BRN52_02615	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRN52_02645	COG2353	YceI-like domain
BRN52_02710	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BRN52_02770	COG3039	Transposase
BRN52_02805	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BRN52_02845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRN52_02850	COG0318	PFAM AMP-dependent synthetase and ligase
BRN52_02860	COG0596	Alpha beta hydrolase
BRN52_02875	COG3177	Filamentation induced by cAMP protein fic
BRN52_02880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRN52_02895	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BRN52_02920	COG4191	Histidine kinase
BRN52_02925	COG0028	Belongs to the TPP enzyme family
BRN52_02945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BRN52_02975	COG5383	Protein conserved in bacteria
BRN52_02990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN52_02995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN52_03000	COG1473	amidohydrolase
BRN52_03025	COG3328	transposase activity
BRN52_03125	COG0358	DNA primase activity
BRN52_03130	COG1295	ribonuclease BN
BRN52_03150	COG1610	YqeY-like protein
BRN52_03155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BRN52_03165	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BRN52_03225	COG2133	pyrroloquinoline quinone binding
BRN52_03235	COG4682	membrane
BRN52_03260	COG0531	amino acid
BRN52_03290	COG4948	Mandelate Racemase Muconate Lactonizing
BRN52_03300	COG3023	N-Acetylmuramoyl-L-alanine amidase
BRN52_03305	COG3039	Transposase
BRN52_03310	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BRN52_03355	COG3039	Transposase
BRN52_03400	COG0183	Belongs to the thiolase family
BRN52_03435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BRN52_03450	COG3104	oligopeptide transport
BRN52_03480	COG1320	monovalent cation:proton antiporter activity
BRN52_03485	COG2212	antiporter activity
BRN52_03495	COG0651	ATP synthesis coupled electron transport
BRN52_03500	COG1006	Multisubunit Na H antiporter MnhC subunit
BRN52_03505	COG2111	Na H antiporter
BRN52_03505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRN52_03540	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BRN52_03550	COG0456	acetyltransferase
BRN52_03580	COG4221	oxidoreductase activity
BRN52_03640	COG0697	spore germination
BRN52_03645	COG4305	rare lipoprotein A
BRN52_03650	COG5297	Belongs to the glycosyl hydrolase family 6
BRN52_03660	COG1113	amino acid transport
BRN52_03670	COG0598	Magnesium transport protein CorA
BRN52_03740	COG0840	transmembrane signaling receptor activity
BRN52_03750	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN52_03750	COG5297	Belongs to the glycosyl hydrolase family 6
BRN52_03755	COG0659	secondary active sulfate transmembrane transporter activity
BRN52_03805	COG3275	phosphorelay sensor kinase activity
BRN52_03840	COG1505	serine-type exopeptidase activity
BRN52_03885	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BRN52_03915	COG0308	aminopeptidase N
BRN52_03920	COG2199	diguanylate cyclase activity
BRN52_03970	COG3039	Transposase
BRN52_03980	COG1077	Cell shape determining protein MreB Mrl
BRN52_03985	COG1792	Involved in formation and maintenance of cell shape
BRN52_04000	COG0772	Belongs to the SEDS family
BRN52_04070	COG2951	lytic endotransglycosylase activity
BRN52_04075	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BRN52_04085	COG1686	Belongs to the peptidase S11 family
BRN52_04120	COG1051	belongs to the nudix hydrolase family
BRN52_04120	COG1056	cytidyltransferase-related domain
BRN52_04155	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BRN52_04160	COG0673	inositol 2-dehydrogenase activity
BRN52_04165	COG2823	Periplasmic or secreted lipoprotein
BRN52_04170	COG4251	negative regulation of phosphorylation
BRN52_04175	COG0784	Response regulator, receiver
BRN52_04180	COG4191	Histidine kinase
BRN52_04185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BRN52_04240	COG3250	beta-galactosidase activity
BRN52_04265	COG1609	Transcriptional regulator
BRN52_04270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRN52_04275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BRN52_04285	COG1215	transferase activity, transferring glycosyl groups
BRN52_04290	COG1649	PFAM Uncharacterised BCR, COG1649
BRN52_04290	COG0726	polysaccharide deacetylase
BRN52_04410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRN52_04415	COG3039	Transposase
BRN52_04465	COG2205	protein histidine kinase activity
BRN52_04505	COG2205	protein histidine kinase activity
BRN52_04510	COG0745	RESPONSE REGULATOR receiver
BRN52_04560	COG0488	(ABC) transporter
BRN52_04600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRN52_04600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRN52_04630	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BRN52_04655	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BRN52_04660	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BRN52_04670	COG2205	protein histidine kinase activity
BRN52_04675	COG0745	RESPONSE REGULATOR receiver
BRN52_04680	COG0277	FAD linked oxidase domain protein
BRN52_04685	COG1988	membrane-bound metal-dependent
BRN52_04730	COG3116	cell division
BRN52_04745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BRN52_04770	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRN52_04775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BRN52_04800	COG4942	peptidase
BRN52_04800	COG1388	LysM domain
BRN52_04815	COG0494	nUDIX hydrolase
BRN52_04840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BRN52_04855	COG3321	synthase
BRN52_04855	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_04855	COG0604	alcohol dehydrogenase
BRN52_04910	COG2226	methyltransferase
BRN52_04955	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BRN52_04970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRN52_04990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN52_04995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BRN52_05005	COG0667	Aldo Keto reductase
BRN52_05055	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BRN52_05065	COG2175	clavaminate synthase activity
BRN52_05075	COG4181	ATPase activity
BRN52_05090	COG0642	Histidine kinase
BRN52_05105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BRN52_05165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BRN52_05180	COG0123	including yeast histone deacetylase and acetoin utilization protein
BRN52_05185	COG2096	Adenosyltransferase
BRN52_05195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRN52_05200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRN52_05240	COG0583	DNA-binding transcription factor activity
BRN52_05245	COG0318	PFAM AMP-dependent synthetase and ligase
BRN52_05255	COG1024	Enoyl-CoA hydratase
BRN52_05275	COG3386	PFAM SMP-30 Gluconolaconase
BRN52_05360	COG3706	GGDEF domain
BRN52_05360	COG0745	RESPONSE REGULATOR receiver
BRN52_05390	COG2197	response regulator
BRN52_05445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BRN52_05450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN52_05460	COG0583	DNA-binding transcription factor activity
BRN52_05465	COG3634	alkyl hydroperoxide reductase activity
BRN52_05475	COG2890	protein-(glutamine-N5) methyltransferase activity
BRN52_05515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRN52_05515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRN52_05530	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BRN52_05550	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BRN52_05555	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BRN52_05585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BRN52_05600	COG1404	Belongs to the peptidase S8 family
BRN52_05605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BRN52_05640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRN52_05660	COG0521	Mo-molybdopterin cofactor biosynthetic process
BRN52_05700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BRN52_05715	COG0012	GTP binding
BRN52_05745	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BRN52_05750	COG0250	Participates in transcription elongation, termination and antitermination
BRN52_05790	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BRN52_05830	COG0089	rRNA binding
BRN52_05855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BRN52_05860	COG0255	Belongs to the universal ribosomal protein uL29 family
BRN52_05865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BRN52_05875	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BRN52_05885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BRN52_05900	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BRN52_05905	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BRN52_05910	COG1841	ribosomal large subunit assembly
BRN52_05920	COG0201	protein transport
BRN52_05925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BRN52_05940	COG0202	RNA polymerase activity
BRN52_05945	COG0203	ribosomal protein L17
BRN52_06010	COG3551	Protein conserved in bacteria
BRN52_06040	COG2194	sulfuric ester hydrolase activity
BRN52_06050	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BRN52_06055	COG0745	RESPONSE REGULATOR receiver
BRN52_06060	COG0642	Histidine kinase
BRN52_06070	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BRN52_06075	COG2894	cell division
BRN52_06095	COG4585	Histidine kinase
BRN52_06100	COG2197	response regulator
BRN52_06115	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BRN52_06145	COG2963	transposase activity
BRN52_06205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN52_06215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN52_06220	COG3501	Rhs element vgr protein
BRN52_06255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN52_06260	COG3501	Rhs element vgr protein
BRN52_06325	COG3501	Rhs element vgr protein
BRN52_06350	COG3501	Rhs element vgr protein
BRN52_06360	COG3501	Rhs element vgr protein
BRN52_06425	COG3501	Rhs element vgr protein
BRN52_06475	COG0732	type I restriction modification DNA specificity domain
BRN52_06480	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BRN52_06490	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BRN52_06510	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BRN52_06515	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BRN52_06525	COG0732	type I restriction modification DNA specificity domain
BRN52_06530	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BRN52_06615	COG0587	DNA-directed DNA polymerase activity
BRN52_06635	COG1297	OPT oligopeptide transporter protein
BRN52_06660	COG1506	peptidase
BRN52_06660	COG0823	Involved in the tonB-independent uptake of proteins
BRN52_06680	COG1917	Cupin 2, conserved barrel domain protein
BRN52_06680	COG2207	Transcriptional regulator
BRN52_06710	COG0753	catalase activity
BRN52_06725	COG3039	Transposase
BRN52_06760	COG0126	phosphoglycerate kinase activity
BRN52_06770	COG0469	pyruvate kinase activity
BRN52_06780	COG3588	fructose-bisphosphate aldolase
BRN52_06785	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BRN52_06840	COG0784	Response regulator, receiver
BRN52_06840	COG2198	Histidine kinase
BRN52_06840	COG2205	protein histidine kinase activity
BRN52_06870	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRN52_06880	COG0529	Catalyzes the synthesis of activated sulfate
BRN52_06880	COG2895	sulfate adenylyltransferase (ATP) activity
BRN52_06895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN52_06900	COG0308	aminopeptidase N
BRN52_06930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRN52_06965	COG1970	mechanosensitive ion channel activity
BRN52_07000	COG3273	potassium ion transport
BRN52_07000	COG0471	metal ion transport
BRN52_07115	COG3039	Transposase
BRN52_07140	COG3039	Transposase
BRN52_07200	COG3118	belongs to the thioredoxin family
BRN52_07230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BRN52_07285	COG3039	Transposase
BRN52_07295	COG2968	Membrane
BRN52_07305	COG1530	ribonuclease E activity
BRN52_07310	COG3164	Protein of unknown function
BRN52_07320	COG0312	modulator of DNA gyrase
BRN52_07330	COG0312	modulator of DNA gyrase
BRN52_07355	COG0142	geranyltranstransferase activity
BRN52_07365	COG0037	tRNA processing
BRN52_07370	COG1785	Belongs to the alkaline phosphatase family
BRN52_07375	COG1301	dicarboxylic acid transport
BRN52_07390	COG0791	NLP P60 protein
BRN52_07395	COG0791	NLP P60 protein
BRN52_07400	COG1047	Peptidyl-prolyl cis-trans
BRN52_07405	COG2311	Membrane
BRN52_07410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN52_07455	COG0489	protein tyrosine kinase activity
BRN52_07480	COG0412	Dienelactone hydrolase
BRN52_07490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN52_07540	COG2890	protein-(glutamine-N5) methyltransferase activity
BRN52_07550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BRN52_07555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BRN52_07590	COG0133	tryptophan synthase activity
BRN52_07675	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRN52_07695	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BRN52_07700	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BRN52_07705	COG1034	ATP synthesis coupled electron transport
BRN52_07710	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BRN52_07725	COG0713	ATP synthesis coupled electron transport
BRN52_07740	COG1007	ATP synthesis coupled electron transport
BRN52_07755	COG0195	Participates in both transcription termination and antitermination
BRN52_07775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BRN52_07810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRN52_07815	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRN52_07825	COG2095	MarC family integral membrane protein
BRN52_07840	COG1611	Belongs to the LOG family
BRN52_07845	COG3039	Transposase
BRN52_07890	COG4969	Belongs to the N-Me-Phe pilin family
BRN52_07895	COG0556	nucleotide-excision repair
BRN52_07940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BRN52_07945	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BRN52_07950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BRN52_07955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BRN52_07965	COG0776	regulation of translation
BRN52_08010	COG0438	transferase activity, transferring glycosyl groups
BRN52_08015	COG0438	transferase activity, transferring glycosyl groups
BRN52_08065	COG3040	lipid binding
BRN52_08195	COG0552	protein localization to endoplasmic reticulum
BRN52_08205	COG3938	Belongs to the proline racemase family
BRN52_08210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN52_08225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRN52_08235	COG0006	proline dipeptidase activity
BRN52_08250	COG0531	amino acid
BRN52_08300	COG4206	TonB-dependent receptor
BRN52_08330	COG4206	TonB-dependent receptor
BRN52_08400	COG0746	molybdenum cofactor guanylyltransferase activity
BRN52_08425	COG1648	precorrin-2 dehydrogenase activity
BRN52_08425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BRN52_08455	COG3039	Transposase
BRN52_08495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BRN52_08535	COG1530	ribonuclease E activity
BRN52_08545	COG3064	Membrane
BRN52_08550	COG0428	transporter
BRN52_08555	COG0428	transporter
BRN52_08645	COG3039	Transposase
BRN52_08735	COG3501	Rhs element vgr protein
BRN52_08770	COG0631	protein serine/threonine phosphatase activity
BRN52_08775	COG0515	serine threonine protein kinase
BRN52_08805	COG1858	cytochrome C peroxidase
BRN52_08860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN52_08865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN52_08915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRN52_08935	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRN52_08950	COG1595	DNA-templated transcription, initiation
BRN52_09000	COG2244	polysaccharide biosynthetic process
BRN52_09030	COG2264	protein methyltransferase activity
BRN52_09040	COG0438	transferase activity, transferring glycosyl groups
BRN52_09055	COG1136	(ABC) transporter
BRN52_09060	COG1132	(ABC) transporter
BRN52_09070	COG0477	Major facilitator Superfamily
BRN52_09090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BRN52_09105	COG1253	flavin adenine dinucleotide binding
BRN52_09120	COG0306	phosphate transporter
BRN52_09175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BRN52_09200	COG2840	Smr protein MutS2
BRN52_09215	COG1238	metal cluster binding
BRN52_09230	COG1534	Rna-binding protein
BRN52_09240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BRN52_09245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BRN52_09255	COG1923	regulation of RNA biosynthetic process
BRN52_09260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BRN52_09265	COG1546	Belongs to the CinA family
BRN52_09290	COG2137	regulation of response to DNA damage stimulus
BRN52_09300	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BRN52_09325	COG0305	Participates in initiation and elongation during chromosome replication
BRN52_09330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BRN52_09350	COG1741	Belongs to the pirin family
BRN52_09355	COG0583	DNA-binding transcription factor activity
BRN52_09385	COG0351	phosphomethylpyrimidine kinase
BRN52_09395	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BRN52_09400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRN52_09415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRN52_09425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BRN52_09430	COG3734	2-keto-3-deoxy-galactonokinase
BRN52_09445	COG0800	Aldolase
BRN52_09460	COG1501	Belongs to the glycosyl hydrolase 31 family
BRN52_09470	COG1070	Carbohydrate kinase
BRN52_09480	COG0477	Major facilitator Superfamily
BRN52_09550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BRN52_09555	COG2258	MOSC domain
BRN52_09565	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BRN52_09570	COG0505	Belongs to the CarA family
BRN52_09580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BRN52_09585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN52_09595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BRN52_09680	COG0784	Response regulator, receiver
BRN52_09680	COG2198	Histidine kinase
BRN52_09680	COG2205	protein histidine kinase activity
BRN52_09685	COG1024	Enoyl-CoA hydratase
BRN52_09690	COG0318	PFAM AMP-dependent synthetase and ligase
BRN52_09720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN52_09755	COG0840	transmembrane signaling receptor activity
BRN52_09780	COG0835	chemotaxis
BRN52_09800	COG0840	transmembrane signaling receptor activity
BRN52_09805	COG0840	transmembrane signaling receptor activity
BRN52_09810	COG0840	transmembrane signaling receptor activity
BRN52_09815	COG0840	transmembrane signaling receptor activity
BRN52_09825	COG0840	transmembrane signaling receptor activity
BRN52_09840	COG0840	transmembrane signaling receptor activity
BRN52_09855	COG0840	transmembrane signaling receptor activity
BRN52_09880	COG0745	RESPONSE REGULATOR receiver
BRN52_09890	COG0835	chemotaxis
BRN52_09895	COG1192	Involved in chromosome partitioning
BRN52_09900	COG1360	Flagellar Motor Protein
BRN52_09905	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BRN52_09925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRN52_09935	COG4771	TonB-dependent receptor
BRN52_10015	COG3501	Rhs element vgr protein
BRN52_10070	COG3039	Transposase
BRN52_10085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRN52_10085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRN52_10090	COG1105	Belongs to the carbohydrate kinase PfkB family
BRN52_10095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN52_10095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRN52_10100	COG1609	Transcriptional regulator
BRN52_10120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN52_10125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN52_10135	COG2902	Dehydrogenase
BRN52_10145	COG3039	Transposase
BRN52_10155	COG0784	Response regulator, receiver
BRN52_10155	COG2205	protein histidine kinase activity
BRN52_10155	COG5002	protein histidine kinase activity
BRN52_10160	COG2733	membrane
BRN52_10170	COG1121	(ABC) transporter
BRN52_10195	COG0243	molybdopterin cofactor binding
BRN52_10205	COG0477	Major facilitator Superfamily
BRN52_10210	COG3706	GGDEF domain
BRN52_10210	COG0745	RESPONSE REGULATOR receiver
BRN52_10215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN52_10220	COG0174	glutamine synthetase
BRN52_10260	COG3842	ATPase activity
BRN52_10265	COG1176	ABC-type spermidine putrescine transport system, permease component I
BRN52_10270	COG1177	transmembrane transport
BRN52_10280	COG1012	belongs to the aldehyde dehydrogenase family
BRN52_10295	COG4535	Mg2 and Co2 transporter CorC
BRN52_10315	COG1702	phosphate starvation-inducible protein PhoH
BRN52_10340	COG0741	lytic transglycosylase activity
BRN52_10350	COG0723	plastoquinol--plastocyanin reductase activity
BRN52_10355	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BRN52_10360	COG2857	Cytochrome c1
BRN52_10365	COG0625	glutathione transferase activity
BRN52_10370	COG2969	positive regulation of protein catabolic process
BRN52_10415	COG3328	transposase activity
BRN52_10420	COG3039	Transposase
BRN52_10510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN52_10530	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRN52_10535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BRN52_10535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BRN52_10540	COG0802	atpase or kinase
BRN52_10545	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRN52_10575	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_10595	COG2081	HI0933 family
BRN52_10600	COG4681	YaeQ
BRN52_10615	COG0625	glutathione transferase activity
BRN52_10625	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BRN52_10635	COG0513	Belongs to the DEAD box helicase family
BRN52_10670	COG0483	inositol monophosphate 1-phosphatase activity
BRN52_10685	COG5001	Diguanylate cyclase
BRN52_10685	COG3300	MHYT domain
BRN52_10690	COG1509	lysine 2,3-aminomutase activity
BRN52_10705	COG0402	S-adenosylhomocysteine deaminase activity
BRN52_10735	COG4677	pectinesterase activity
BRN52_10760	COG3039	Transposase
BRN52_10795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BRN52_10805	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BRN52_10820	COG2166	iron-sulfur cluster assembly
BRN52_10835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BRN52_10840	COG0137	argininosuccinate synthase activity
BRN52_10850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRN52_10855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BRN52_10920	COG1271	oxidase subunit
BRN52_10930	COG4988	ABC transporter
BRN52_10935	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BRN52_11045	COG3209	COG3209 Rhs family protein
BRN52_11080	COG2198	Histidine kinase
BRN52_11080	COG0643	Histidine kinase
BRN52_11100	COG0455	bacterial-type flagellum organization
BRN52_11110	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BRN52_11125	COG5001	Diguanylate cyclase
BRN52_11125	COG3300	MHYT domain
BRN52_11130	COG3300	MHYT domain
BRN52_11130	COG5001	Diguanylate cyclase
BRN52_11135	COG1684	flagellar biosynthetic protein fliR
BRN52_11140	COG1987	bacterial-type flagellum assembly
BRN52_11155	COG3190	flagellar
BRN52_11205	COG1677	Flagellar hook-basal body complex protein FliE
BRN52_11245	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_11255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRN52_11270	COG2204	response regulator
BRN52_11275	COG2201	protein-glutamate methylesterase activity
BRN52_11305	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BRN52_11310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BRN52_11340	COG4786	Flagellar basal body rod
BRN52_11350	COG4787	bacterial-type flagellum-dependent cell motility
BRN52_11355	COG1749	Flagellar hook protein flgE
BRN52_11360	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BRN52_11365	COG1558	bacterial-type flagellum-dependent cell motility
BRN52_11375	COG0835	chemotaxis
BRN52_11375	COG0784	Response regulator, receiver
BRN52_11395	COG5002	protein histidine kinase activity
BRN52_11405	COG4585	Histidine kinase
BRN52_11410	COG5001	Diguanylate cyclase
BRN52_11445	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BRN52_11450	COG0542	response to heat
BRN52_11455	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BRN52_11475	COG0492	ferredoxin-NADP+ reductase activity
BRN52_11480	COG1674	ftsk spoiiie
BRN52_11505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BRN52_11525	COG0038	chloride channel
BRN52_11530	COG0183	Belongs to the thiolase family
BRN52_11535	COG1024	Enoyl-CoA hydratase
BRN52_11535	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRN52_11545	COG0105	UTP biosynthetic process
BRN52_11560	COG1426	Protein conserved in bacteria
BRN52_11570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN52_11580	COG0303	'Molybdopterin
BRN52_11660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BRN52_11675	COG3039	Transposase
BRN52_11715	COG0531	amino acid
BRN52_11720	COG0531	amino acid
BRN52_11730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BRN52_11735	COG0277	FAD linked oxidase domain protein
BRN52_11800	COG0436	Aminotransferase
BRN52_11825	COG1187	pseudouridine synthase activity
BRN52_11830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BRN52_11835	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BRN52_11840	COG2350	Protein conserved in bacteria
BRN52_11870	COG1175	transmembrane transport
BRN52_11875	COG0395	ABC-type sugar transport system, permease component
BRN52_11900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRN52_11910	COG2957	Belongs to the agmatine deiminase family
BRN52_11920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BRN52_11930	COG0539	negative regulation of cytoplasmic translation
BRN52_11945	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BRN52_11950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRN52_11960	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BRN52_12000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRN52_12005	COG0583	DNA-binding transcription factor activity
BRN52_12035	COG0583	DNA-binding transcription factor activity
BRN52_12040	COG0583	DNA-binding transcription factor activity
BRN52_12050	COG2201	protein-glutamate methylesterase activity
BRN52_12060	COG1914	H( )-stimulated, divalent metal cation uptake system
BRN52_12065	COG1321	iron dependent repressor
BRN52_12070	COG0590	tRNA wobble adenosine to inosine editing
BRN52_12080	COG0668	transmembrane transport
BRN52_12105	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_12110	COG1183	phosphatidylcholine synthase activity
BRN52_12120	COG3243	poly(R)-hydroxyalkanoic acid synthase
BRN52_12135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN52_12135	COG0723	plastoquinol--plastocyanin reductase activity
BRN52_12145	COG2183	response to ionizing radiation
BRN52_12160	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BRN52_12175	COG0671	phosphoesterase, PA-phosphatase related
BRN52_12200	COG1794	racemase activity, acting on amino acids and derivatives
BRN52_12205	COG0697	spore germination
BRN52_12230	COG1012	belongs to the aldehyde dehydrogenase family
BRN52_12265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BRN52_12280	COG0124	histidyl-tRNA synthetase
BRN52_12335	COG0140	phosphoribosyl-ATP diphosphatase activity
BRN52_12335	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BRN52_12435	COG0653	protein targeting
BRN52_12480	COG2201	protein-glutamate methylesterase activity
BRN52_12490	COG2801	Transposase and inactivated derivatives
BRN52_12565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BRN52_12590	COG0811	peptide transport
BRN52_12620	COG4591	ABC-type transport system involved in lipoprotein release permease component
BRN52_12635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BRN52_12650	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BRN52_12665	COG0354	folic acid binding
BRN52_12680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRN52_12690	COG0363	glucosamine-6-phosphate deaminase activity
BRN52_12695	COG0129	dihydroxy-acid dehydratase activity
BRN52_12700	COG0800	Aldolase
BRN52_12735	COG5002	protein histidine kinase activity
BRN52_12735	COG2205	protein histidine kinase activity
BRN52_12735	COG0784	Response regulator, receiver
BRN52_12755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BRN52_12760	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BRN52_12765	COG0431	NADPH-dependent FMN reductase
BRN52_12770	COG1393	Belongs to the ArsC family
BRN52_12790	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRN52_12820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BRN52_12845	COG1247	-acetyltransferase
BRN52_12870	COG3706	GGDEF domain
BRN52_12920	COG0386	Belongs to the glutathione peroxidase family
BRN52_13010	COG2203	Gaf domain
BRN52_13010	COG3706	GGDEF domain
BRN52_13010	COG5001	Diguanylate cyclase
BRN52_13010	COG4251	negative regulation of phosphorylation
BRN52_13030	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN52_13070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BRN52_13095	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRN52_13145	COG4566	intracellular signal transduction
BRN52_13185	COG1605	Chorismate mutase
BRN52_13185	COG0077	Prephenate dehydratase
BRN52_13195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BRN52_13245	COG2986	histidine ammonia-lyase
BRN52_13255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BRN52_13295	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BRN52_13310	COG3115	cell septum assembly
BRN52_13335	COG0316	Belongs to the HesB IscA family
BRN52_13370	COG0288	reversible hydration of carbon dioxide
BRN52_13400	COG2925	Exonuclease
BRN52_13410	COG0667	Aldo Keto reductase
BRN52_13480	COG0494	nUDIX hydrolase
BRN52_13490	COG1024	Enoyl-CoA hydratase
BRN52_13500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BRN52_13535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BRN52_13540	COG0573	inorganic phosphate transmembrane transporter activity
BRN52_13555	COG0704	Plays a role in the regulation of phosphate uptake
BRN52_13565	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRN52_13585	COG3328	transposase activity
BRN52_13615	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRN52_13625	COG1862	Preprotein translocase
BRN52_13670	COG3039	Transposase
BRN52_13715	COG3501	Rhs element vgr protein
BRN52_13735	COG3501	Rhs element vgr protein
BRN52_13815	COG0405	Gamma-glutamyltransferase
BRN52_13820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRN52_13840	COG0742	ribosomal rna small subunit methyltransferase
BRN52_13920	COG0583	DNA-binding transcription factor activity
BRN52_13930	COG3039	Transposase
BRN52_14010	COG1278	Cold shock
BRN52_14060	COG3039	Transposase
BRN52_14075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRN52_14090	COG0557	exoribonuclease II activity
BRN52_14120	COG1960	acyl-CoA dehydrogenase activity
BRN52_14130	COG1410	methionine synthase
BRN52_14130	COG0646	methionine synthase
BRN52_14135	COG1410	methionine synthase
BRN52_14135	COG0646	methionine synthase
BRN52_14145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN52_14185	COG0386	Belongs to the glutathione peroxidase family
BRN52_14195	COG1725	Transcriptional regulator
BRN52_14200	COG1131	(ABC) transporter
BRN52_14295	COG2850	peptidyl-arginine hydroxylation
BRN52_14330	COG1132	(ABC) transporter
BRN52_14345	COG0583	DNA-binding transcription factor activity
BRN52_14365	COG1605	Chorismate mutase
BRN52_14365	COG0287	Prephenate dehydrogenase
BRN52_14370	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BRN52_14400	COG0497	DNA recombination
BRN52_14410	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN52_14420	COG2914	Belongs to the UPF0125 (RnfH) family
BRN52_14430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BRN52_14445	COG1960	acyl-CoA dehydrogenase activity
BRN52_14500	COG2814	Major facilitator Superfamily
BRN52_14505	COG1566	PFAM secretion protein HlyD family protein
BRN52_14520	COG2207	Transcriptional regulator
BRN52_14555	COG4774	siderophore transport
BRN52_14570	COG0367	asparagine synthase
BRN52_14585	COG1393	Belongs to the ArsC family
BRN52_14605	COG0024	Methionine aminopeptidase
BRN52_14670	COG0575	Belongs to the CDS family
BRN52_14680	COG0750	zinc metalloprotease
BRN52_14730	COG4771	TonB-dependent receptor
BRN52_14735	COG1131	(ABC) transporter
BRN52_14815	COG2895	sulfate adenylyltransferase (ATP) activity
BRN52_14815	COG0529	Catalyzes the synthesis of activated sulfate
BRN52_14850	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRN52_14870	COG2040	homocysteine
BRN52_14875	COG0833	amino acid
BRN52_14905	COG2878	Part of a membrane complex involved in electron transport
BRN52_14925	COG1595	DNA-templated transcription, initiation
BRN52_14950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRN52_14965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRN52_14970	COG0251	oxidation-reduction process
BRN52_14980	COG0392	lysyltransferase activity
BRN52_14980	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BRN52_15025	COG2814	Major facilitator Superfamily
BRN52_15030	COG1902	pentaerythritol trinitrate reductase activity
BRN52_15045	COG2824	Alkylphosphonate utilization operon protein PhnA
BRN52_15060	COG1047	Peptidyl-prolyl cis-trans
BRN52_15100	COG3039	Transposase
BRN52_15105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BRN52_15120	COG1451	nucleotide metabolic process
BRN52_15145	COG0183	Belongs to the thiolase family
BRN52_15160	COG0745	RESPONSE REGULATOR receiver
BRN52_15160	COG3706	GGDEF domain
BRN52_15175	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BRN52_15175	COG1793	dna ligase
BRN52_15185	COG1793	dna ligase
BRN52_15190	COG1201	RNA secondary structure unwinding
BRN52_15210	COG1278	Cold shock
BRN52_15215	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BRN52_15230	COG3046	protein related to deoxyribodipyrimidine photolyase
BRN52_15235	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BRN52_15240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BRN52_15315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRN52_15330	COG1024	Enoyl-CoA hydratase
BRN52_15330	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRN52_15350	COG1024	Enoyl-CoA hydratase
BRN52_15355	COG1960	acyl-CoA dehydrogenase activity
BRN52_15430	COG2353	YceI-like domain
BRN52_15440	COG2353	YceI-like domain
BRN52_15455	COG1760	l-serine dehydratase
BRN52_15465	COG0626	cystathionine gamma-synthase activity
BRN52_15470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN52_15475	COG0739	heme binding
BRN52_15485	COG1272	protein, Hemolysin III
BRN52_15515	COG0463	Glycosyl transferase, family 2
BRN52_15525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BRN52_15535	COG4771	TonB-dependent receptor
BRN52_15540	COG1309	transcriptional regulator
BRN52_15550	COG1960	acyl-CoA dehydrogenase activity
BRN52_15600	COG0330	HflC and HflK could
BRN52_15615	COG3956	TIGRFAM MazG family protein
BRN52_15625	COG0494	nUDIX hydrolase
BRN52_15635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BRN52_15640	COG0837	glucose binding
BRN52_15655	COG1388	LysM domain
BRN52_15655	COG3858	chitin binding
BRN52_15675	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN52_15740	COG3537	Alpha-1,2-mannosidase
BRN52_15790	COG3142	Participates in the control of copper homeostasis
BRN52_15795	COG1446	asparaginase
BRN52_15855	COG0840	transmembrane signaling receptor activity
BRN52_15860	COG0835	chemotaxis
BRN52_15875	COG0189	ligase activity
BRN52_15885	COG1397	ADP-ribosylglycohydrolase
BRN52_15895	COG1199	ATP-dependent helicase activity
BRN52_15905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BRN52_15920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRN52_15940	COG0535	radical SAM domain protein
BRN52_15945	COG0535	radical SAM domain protein
BRN52_15970	COG1643	Atp-dependent helicase
BRN52_15975	COG0783	Belongs to the Dps family
BRN52_15985	COG0514	ATP-dependent DNA helicase (RecQ)
BRN52_16035	COG0602	queuosine metabolic process
BRN52_16045	COG2885	chlorophyll binding
BRN52_16060	COG0848	biopolymer transport protein
BRN52_16070	COG0824	Thioesterase
BRN52_16220	COG3039	Transposase
BRN52_16225	COG3209	COG3209 Rhs family protein
BRN52_16230	COG3039	Transposase
BRN52_16250	COG3039	Transposase
BRN52_16305	COG3209	COG3209 Rhs family protein
BRN52_16315	COG3501	Rhs element vgr protein
BRN52_16325	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BRN52_16330	COG1845	cytochrome c oxidase, subunit III
BRN52_16335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BRN52_16365	COG0196	riboflavin kinase activity
BRN52_16370	COG0728	peptidoglycan biosynthetic process
BRN52_16375	COG0268	Binds directly to 16S ribosomal RNA
BRN52_16395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BRN52_16400	COG0824	Thioesterase
BRN52_16415	COG1946	Acyl-CoA thioesterase
BRN52_16425	COG1595	DNA-templated transcription, initiation
BRN52_16480	COG1877	trehalose-phosphatase activity
BRN52_16485	COG3387	PFAM Glycoside hydrolase 15-related
BRN52_16510	COG0564	pseudouridine synthase activity
BRN52_16515	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN52_16520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BRN52_16520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRN52_16530	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BRN52_16575	COG2194	sulfuric ester hydrolase activity
BRN52_16580	COG4969	Belongs to the N-Me-Phe pilin family
BRN52_16590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BRN52_16625	COG3039	Transposase
BRN52_16655	COG1132	(ABC) transporter
BRN52_16685	COG0745	RESPONSE REGULATOR receiver
BRN52_16690	COG5000	phosphorelay sensor kinase activity
BRN52_16690	COG5002	protein histidine kinase activity
BRN52_16695	COG0475	glutathione-regulated potassium exporter activity
BRN52_16730	COG1187	pseudouridine synthase activity
BRN52_16735	COG5001	Diguanylate cyclase
BRN52_16735	COG5002	protein histidine kinase activity
BRN52_16855	COG0415	Belongs to the DNA photolyase family
BRN52_16860	COG0305	Participates in initiation and elongation during chromosome replication
BRN52_16870	COG0367	asparagine synthase
BRN52_16885	COG1960	acyl-CoA dehydrogenase activity
BRN52_16900	COG0084	hydrolase, TatD family'
BRN52_16905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BRN52_16965	COG0735	belongs to the Fur family
BRN52_17000	COG3039	Transposase
BRN52_17035	COG3039	Transposase
BRN52_17065	COG2205	protein histidine kinase activity
BRN52_17075	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BRN52_17085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BRN52_17095	COG0643	Histidine kinase
BRN52_17095	COG2198	Histidine kinase
BRN52_17105	COG0840	transmembrane signaling receptor activity
BRN52_17110	COG0835	chemotaxis
BRN52_17115	COG2200	EAL domain
BRN52_17115	COG2202	Pas domain
BRN52_17115	COG2199	diguanylate cyclase activity
BRN52_17120	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BRN52_17135	COG3590	peptidase
BRN52_17150	COG0588	phosphoglycerate mutase activity
BRN52_17155	COG1515	deoxyribonuclease V activity
BRN52_17165	COG1741	Belongs to the pirin family
BRN52_17220	COG3501	Rhs element vgr protein
BRN52_17240	COG3039	Transposase
BRN52_17265	COG3501	Rhs element vgr protein
BRN52_17285	COG3501	Rhs element vgr protein
BRN52_17295	COG1741	Belongs to the pirin family
BRN52_17300	COG1966	Carbon starvation protein
BRN52_17305	COG2879	small protein
BRN52_17345	COG4251	negative regulation of phosphorylation
BRN52_17345	COG5001	Diguanylate cyclase
BRN52_17345	COG3706	GGDEF domain
BRN52_17345	COG2203	Gaf domain
BRN52_17350	COG0629	single-stranded DNA binding
BRN52_17355	COG0142	geranyltranstransferase activity
BRN52_17385	COG0527	aspartate kinase activity
BRN52_17395	COG0384	phenazine biosynthesis protein PhzF
BRN52_17410	COG1764	response to oxidative stress
BRN52_17440	COG0519	Catalyzes the synthesis of GMP from XMP
BRN52_17465	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BRN52_17510	COG0693	protein deglycase activity
BRN52_17530	COG1959	2 iron, 2 sulfur cluster binding
BRN52_17535	COG0719	Fe-S assembly protein
BRN52_17540	COG0396	ATPase activity
BRN52_17545	COG0719	Fe-S assembly protein
BRN52_17550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BRN52_17605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BRN52_17615	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BRN52_17620	COG0174	glutamine synthetase
BRN52_17625	COG3328	transposase activity
BRN52_17665	COG0326	Molecular chaperone. Has ATPase activity
BRN52_17670	COG2207	Transcriptional regulator
BRN52_17690	COG0657	acetylesterase activity
BRN52_17690	COG2755	lipolytic protein G-D-S-L family
BRN52_17715	COG0488	(ABC) transporter
BRN52_17760	COG4651	solute:proton antiporter activity
BRN52_17760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BRN52_17775	COG4772	TonB-dependent receptor
BRN52_17785	COG4264	IucA IucC family
BRN52_17790	COG2814	Major facilitator Superfamily
BRN52_17800	COG0019	diaminopimelate decarboxylase activity
BRN52_17860	COG4206	TonB-dependent receptor
BRN52_17900	COG0542	response to heat
BRN52_17950	COG0534	Mate efflux family protein
BRN52_18000	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BRN52_18015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRN52_18065	COG1555	photosystem II stabilization
BRN52_18070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRN52_18085	COG3178	'Phosphotransferase
BRN52_18090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BRN52_18100	COG0628	permease
BRN52_18125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BRN52_18155	COG0271	Belongs to the BolA IbaG family
BRN52_18165	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BRN52_18175	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BRN52_18180	COG1137	ATPase activity
BRN52_18195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN52_18215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN52_18220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRN52_18230	COG2239	Acts as a magnesium transporter
BRN52_18240	COG1294	oxidase, subunit
BRN52_18245	COG1271	oxidase subunit
BRN52_18265	COG1113	amino acid transport
BRN52_18280	COG2197	response regulator
BRN52_18285	COG0531	amino acid
BRN52_18340	COG0789	Transcriptional regulator
BRN52_18355	COG0754	glutathionylspermidine amidase activity
BRN52_18380	COG1842	Phage shock protein A
BRN52_18400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BRN52_18410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BRN52_18445	COG2201	protein-glutamate methylesterase activity
BRN52_18495	COG2201	protein-glutamate methylesterase activity
BRN52_18525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BRN52_18570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRN52_18575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRN52_18600	COG3039	Transposase
BRN52_18620	COG0745	RESPONSE REGULATOR receiver
BRN52_18625	COG2205	protein histidine kinase activity
BRN52_18645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BRN52_18690	COG3453	Protein conserved in bacteria
BRN52_18690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRN52_18695	COG0725	ABC transporter, periplasmic molybdate-binding protein
BRN52_18700	COG4149	molybdate abc transporter
BRN52_18705	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BRN52_18725	COG0642	Histidine kinase
BRN52_18730	COG0745	RESPONSE REGULATOR receiver
BRN52_18740	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_18750	COG1022	Amp-dependent synthetase and ligase
BRN52_18775	COG1376	ErfK ybiS ycfS ynhG family protein
BRN52_18780	COG0739	heme binding
BRN52_18790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BRN52_18795	COG1301	dicarboxylic acid transport
BRN52_18815	COG2304	oxidoreductase activity
BRN52_18835	COG0714	Associated with various cellular activities
BRN52_18885	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BRN52_18905	COG0254	rRNA binding
BRN52_18915	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BRN52_18925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRN52_18950	COG1561	YicC-like family, N-terminal region
BRN52_18970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BRN52_19000	COG0006	proline dipeptidase activity
BRN52_19025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BRN52_19035	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BRN52_19045	COG2912	Transglutaminase-like superfamily
BRN52_19050	COG1773	rubredoxin
BRN52_19055	COG0352	thiamine-phosphate diphosphorylase activity
BRN52_19090	COG0280	phosphate acetyltransferase
BRN52_19090	COG0281	malic enzyme
BRN52_19110	COG4191	Histidine kinase
BRN52_19125	COG0583	DNA-binding transcription factor activity
BRN52_19150	COG2197	response regulator
BRN52_19155	COG1840	ABC-type Fe3 transport system, periplasmic component
BRN52_19160	COG0642	Histidine kinase
BRN52_19180	COG2851	Citrate transporter
BRN52_19185	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_19190	COG1609	Transcriptional regulator
BRN52_19250	COG0726	polysaccharide deacetylase
BRN52_19255	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRN52_19305	COG0242	peptide deformylase activity
BRN52_19325	COG0714	Associated with various cellular activities
BRN52_19345	COG0537	adenosine 5'-monophosphoramidase activity
BRN52_19375	COG0314	molybdopterin synthase activity
BRN52_19380	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BRN52_19395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BRN52_19400	COG1234	tRNA 3'-trailer cleavage
BRN52_19410	COG0859	PFAM glycosyl transferase family 9
BRN52_19420	COG0582	viral genome integration into host DNA
BRN52_19480	COG3501	Rhs element vgr protein
BRN52_19510	COG0631	protein serine/threonine phosphatase activity
BRN52_19520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRN52_19545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BRN52_19580	COG0740	serine-type endopeptidase activity
BRN52_19585	COG0544	peptidyl-prolyl cis-trans isomerase activity
BRN52_19640	COG0473	3-isopropylmalate dehydrogenase activity
BRN52_19665	COG4783	chaperone-mediated protein folding
BRN52_19680	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BRN52_19690	COG0438	transferase activity, transferring glycosyl groups
BRN52_19695	COG0671	phosphoesterase, PA-phosphatase related
BRN52_19720	COG2833	Protein of unknown function (DUF455)
BRN52_19740	COG0285	dihydrofolate synthase activity
BRN52_19750	COG0406	alpha-ribazole phosphatase activity
BRN52_19785	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BRN52_19790	COG4208	sulfate ABC transporter
BRN52_19795	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BRN52_19800	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BRN52_19805	COG0156	8-amino-7-oxononanoate synthase activity
BRN52_19840	COG1902	pentaerythritol trinitrate reductase activity
BRN52_19840	COG0446	pyridine nucleotide-disulphide oxidoreductase
BRN52_19880	COG0584	glycerophosphoryl diester phosphodiesterase
BRN52_19910	COG3039	Transposase
BRN52_19925	COG0625	glutathione transferase activity
BRN52_19935	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BRN52_19960	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BRN52_20100	COG3781	membrane
BRN52_20110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRN52_20140	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BRN52_20160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BRN52_20275	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRN52_20280	COG1538	Outer membrane efflux protein
BRN52_20285	COG1519	Transferase
BRN52_20290	COG1560	Kdo2-lipid A biosynthetic process
BRN52_20340	COG0308	aminopeptidase N
BRN52_20345	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BRN52_20355	COG0330	HflC and HflK could
BRN52_20360	COG0330	HflC and HflK could
BRN52_20380	COG0678	peroxiredoxin activity
BRN52_20465	COG3829	transcription factor binding
BRN52_20490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BRN52_20495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BRN52_20510	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_20535	COG1399	metal-binding, possibly nucleic acid-binding protein
BRN52_20580	COG1518	maintenance of DNA repeat elements
BRN52_20585	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BRN52_20640	COG2188	Transcriptional regulator
BRN52_20655	COG1450	Type ii and iii secretion system protein
BRN52_20670	COG3166	PFAM Fimbrial assembly family protein
BRN52_20675	COG3156	type II secretion system protein K
BRN52_20680	COG4795	General secretion pathway protein
BRN52_20685	COG2165	general secretion pathway protein
BRN52_20690	COG4970	Tfp pilus assembly protein FimT
BRN52_20695	COG2165	general secretion pathway protein
BRN52_20700	COG1459	type II secretion system
BRN52_20710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRN52_20720	COG5295	Hep Hag repeat protein
BRN52_20730	COG0047	phosphoribosylformylglycinamidine synthase activity
BRN52_20730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BRN52_20735	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BRN52_20740	COG4974	Belongs to the 'phage' integrase family
BRN52_20755	COG0795	lipopolysaccharide-transporting ATPase activity
BRN52_20780	COG0525	valine-tRNA ligase activity
BRN52_20815	COG3039	Transposase
BRN52_20850	COG3039	Transposase
BRN52_20890	COG1183	phosphatidylcholine synthase activity
BRN52_20915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRN52_20920	COG1127	ABC transporter
BRN52_20925	COG3218	ABC-type transport auxiliary lipoprotein component
BRN52_20925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRN52_20965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRN52_20970	COG0662	Cupin 2, conserved barrel domain protein
BRN52_20970	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BRN52_20995	COG2086	electron transfer activity
BRN52_21020	COG3328	transposase activity
BRN52_21070	COG0626	cystathionine gamma-synthase activity
BRN52_21100	COG0625	glutathione transferase activity
BRN52_21115	COG0513	Belongs to the DEAD box helicase family
BRN52_21125	COG0720	synthase
BRN52_21140	COG1956	GAF domain-containing protein
BRN52_21180	COG0339	signal peptide processing
BRN52_21230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRN52_21235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN52_21325	COG0356	it plays a direct role in the translocation of protons across the membrane
BRN52_21345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRN52_21355	COG0508	dehydrogenase complex catalyzes the overall conversion of
BRN52_21385	COG2011	ABC-type metal ion transport system permease component
BRN52_21395	COG0697	spore germination
BRN52_21435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BRN52_21440	COG1187	pseudouridine synthase activity
BRN52_21445	COG2813	Specifically methylates the guanine in position
BRN52_21475	COG2202	Pas domain
BRN52_21475	COG2205	protein histidine kinase activity
BRN52_21500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN52_21505	COG1522	sequence-specific DNA binding
BRN52_21550	COG0745	RESPONSE REGULATOR receiver
BRN52_21565	COG1404	Belongs to the peptidase S8 family
BRN52_21585	COG0842	Transport permease protein
BRN52_21590	COG1131	(ABC) transporter
BRN52_21595	COG0025	NhaP-type Na H and K H
BRN52_21610	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BRN52_21620	COG1573	uracil-dna glycosylase
BRN52_21630	COG3384	dioxygenase
BRN52_21645	COG0667	Aldo Keto reductase
BRN52_21660	COG3590	peptidase
BRN52_21680	COG0531	amino acid
BRN52_21695	COG2972	Histidine kinase
BRN52_21760	COG2204	response regulator
BRN52_21775	COG1271	oxidase subunit
BRN52_21780	COG1294	oxidase, subunit
BRN52_21810	COG3039	Transposase
BRN52_21875	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BRN52_21890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BRN52_22180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRN52_22190	COG1560	Kdo2-lipid A biosynthetic process
BRN52_22240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRN52_22240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BRN52_22250	COG0242	peptide deformylase activity
BRN52_22255	COG1652	LysM domain
BRN52_22260	COG0758	DNA mediated transformation
BRN52_22280	COG1754	DNA topoisomerase type I activity
BRN52_22280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BRN52_22300	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_22310	COG0616	signal peptide processing
BRN52_22315	COG0534	Mate efflux family protein
BRN52_22340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BRN52_22370	COG1324	tolerance protein
BRN52_22395	COG0511	ligase activity, forming carbon-carbon bonds
BRN52_22405	COG0439	Biotin carboxylase
BRN52_22465	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BRN52_22510	COG3210	domain, Protein
BRN52_22515	COG2831	hemolysin activation secretion protein
BRN52_22540	COG0671	phosphoesterase, PA-phosphatase related
BRN52_22540	COG2453	phosphatase
BRN52_22545	COG2267	carboxylic ester hydrolase activity
BRN52_22555	COG2267	carboxylic ester hydrolase activity
BRN52_22570	COG0419	ATPase involved in DNA repair
BRN52_22580	COG0151	Belongs to the GarS family
BRN52_22585	COG0577	efflux transmembrane transporter activity
BRN52_22585	COG1136	(ABC) transporter
BRN52_22595	COG1289	transmembrane transporter activity
BRN52_22610	COG2814	Major facilitator Superfamily
BRN52_22635	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BRN52_22715	COG0739	heme binding
BRN52_22730	COG2211	Major facilitator Superfamily
BRN52_22735	COG0708	Exodeoxyribonuclease III
BRN52_22750	COG1192	Involved in chromosome partitioning
BRN52_22755	COG1475	DNA binding
BRN52_22770	COG0463	Glycosyl transferase, family 2
BRN52_22795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BRN52_22820	COG4221	oxidoreductase activity
BRN52_22845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BRN52_22850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN52_22855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BRN52_22865	COG3485	protocatechuate 3,4-dioxygenase
BRN52_22870	COG3485	protocatechuate 3,4-dioxygenase
BRN52_22910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRN52_22920	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRN52_22935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BRN52_22935	COG1042	CoA-binding domain protein
BRN52_22935	COG0045	succinate-CoA ligase (ADP-forming) activity
BRN52_22945	COG2239	Acts as a magnesium transporter
BRN52_22965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRN52_22970	COG3387	PFAM Glycoside hydrolase 15-related
BRN52_22985	COG3100	YcgL domain-containing protein
BRN52_22990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRN52_23000	COG0463	Glycosyl transferase, family 2
BRN52_23015	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_23040	COG1040	competence protein
BRN52_23060	COG0628	permease
BRN52_23070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRN52_23080	COG1595	DNA-templated transcription, initiation
BRN52_23085	COG0753	catalase activity
BRN52_23130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRN52_23135	COG0180	Tryptophanyl-tRNA synthetase
BRN52_23140	COG3237	CsbD-like
BRN52_23200	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BRN52_23200	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BRN52_23225	COG2205	protein histidine kinase activity
BRN52_23230	COG0745	RESPONSE REGULATOR receiver
BRN52_23240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRN52_23270	COG1566	PFAM secretion protein HlyD family protein
BRN52_23290	COG3039	Transposase
BRN52_23295	COG1199	ATP-dependent helicase activity
BRN52_23330	COG0583	DNA-binding transcription factor activity
BRN52_23380	COG0625	glutathione transferase activity
BRN52_23415	COG4555	ABC transporter
BRN52_23425	COG1476	TRANSCRIPTIONal
BRN52_23450	COG1131	(ABC) transporter
BRN52_23455	COG0842	Transport permease protein
BRN52_23465	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BRN52_23560	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRN52_23585	COG0564	pseudouridine synthase activity
BRN52_23615	COG0339	signal peptide processing
BRN52_23645	COG3254	rhamnose metabolic process
BRN52_23650	COG0738	Major facilitator superfamily
BRN52_23655	COG1414	Transcriptional regulator
BRN52_23670	COG2205	protein histidine kinase activity
BRN52_23685	COG3459	Glycosyltransferase 36 associated
BRN52_23690	COG2211	Major facilitator Superfamily
BRN52_23695	COG3265	gluconokinase activity
BRN52_23705	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN52_23750	COG3039	Transposase
BRN52_23820	COG1127	ABC transporter
BRN52_23825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRN52_23830	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRN52_23845	COG2853	Lipoprotein
BRN52_23935	COG0676	glucose-6-phosphate 1-epimerase activity
BRN52_23960	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN52_23970	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN52_23980	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN52_23990	COG1064	alcohol dehydrogenase
BRN52_24050	COG1522	sequence-specific DNA binding
BRN52_24055	COG3186	Phenylalanine-4-hydroxylase
BRN52_24070	COG2755	lipolytic protein G-D-S-L family
BRN52_24095	COG0656	L-ascorbic acid biosynthetic process
BRN52_24100	COG2130	NADP-dependent
BRN52_24105	COG0667	Aldo Keto reductase
BRN52_24115	COG1187	pseudouridine synthase activity
BRN52_24130	COG1643	Atp-dependent helicase
BRN52_24135	COG4807	Protein conserved in bacteria
BRN52_24140	COG4948	Mandelate Racemase Muconate Lactonizing
BRN52_24150	COG0179	Fumarylacetoacetate (FAA) hydrolase
BRN52_24155	COG1028	Short-chain dehydrogenase reductase Sdr
BRN52_24175	COG3507	Belongs to the glycosyl hydrolase 43 family
BRN52_24220	COG3162	membrane
BRN52_24225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BRN52_24240	COG0708	Exodeoxyribonuclease III
BRN52_24255	COG2091	lysine biosynthetic process via aminoadipic acid
BRN52_24265	COG3540	Alkaline phosphatase
BRN52_24285	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BRN52_24290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BRN52_24295	COG2159	amidohydrolase
BRN52_24310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRN52_24315	COG0583	DNA-binding transcription factor activity
BRN52_24320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN52_24340	COG0210	DNA helicase
BRN52_24355	COG0531	amino acid
BRN52_24365	COG1322	Protein conserved in bacteria
BRN52_24375	COG0386	Belongs to the glutathione peroxidase family
BRN52_24425	COG0793	Belongs to the peptidase S41A family
BRN52_24430	COG4942	peptidase
BRN52_24440	COG2234	aminopeptidase activity
BRN52_24485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRN52_24490	COG0302	gtp cyclohydrolase
BRN52_24510	COG0477	Major facilitator Superfamily
BRN52_24620	COG1929	Belongs to the glycerate kinase type-1 family
BRN52_24625	COG2271	Major facilitator Superfamily
BRN52_24640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRN52_24650	COG0861	Integral membrane protein TerC family
BRN52_24660	COG0584	glycerophosphoryl diester phosphodiesterase
BRN52_24670	COG0671	phosphoesterase, PA-phosphatase related
BRN52_24680	COG0726	polysaccharide deacetylase
BRN52_24695	COG0230	Belongs to the bacterial ribosomal protein bL34 family