locus-tag	class	description
APZ20_00020	COG0187	DNA topoisomerase II activity
APZ20_00030	COG0501	Belongs to the peptidase M48B family
APZ20_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APZ20_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APZ20_00090	COG4772	TonB-dependent receptor
APZ20_00100	COG3039	Transposase
APZ20_00110	COG1755	Isoprenylcysteine carboxyl methyltransferase
APZ20_00125	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APZ20_00130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ20_00160	COG3039	Transposase
APZ20_00225	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_00255	COG1090	epimerase
APZ20_00260	COG0642	Histidine kinase
APZ20_00270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APZ20_00365	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APZ20_00455	COG3264	Mechanosensitive ion channel
APZ20_00455	COG1511	domain protein
APZ20_00465	COG3293	Transposase
APZ20_00475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APZ20_00480	COG2354	Protein conserved in bacteria
APZ20_00490	COG0745	RESPONSE REGULATOR receiver
APZ20_00490	COG3706	GGDEF domain
APZ20_00505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APZ20_00530	COG0702	epimerase
APZ20_00535	COG1858	cytochrome C peroxidase
APZ20_00600	COG0513	Belongs to the DEAD box helicase family
APZ20_00610	COG3039	Transposase
APZ20_00630	COG0508	dehydrogenase complex catalyzes the overall conversion of
APZ20_00650	COG1136	(ABC) transporter
APZ20_00675	COG1136	(ABC) transporter
APZ20_00690	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_00715	COG1272	protein, Hemolysin III
APZ20_00720	COG1205	dead DEAH box helicase
APZ20_00720	COG1111	helicase
APZ20_00775	COG0070	glutamate synthase
APZ20_00775	COG0067	glutamate synthase
APZ20_00775	COG0069	glutamate synthase activity
APZ20_00780	COG0493	'glutamate synthase
APZ20_00800	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_00820	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
APZ20_00825	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
APZ20_00830	COG1609	Transcriptional regulator
APZ20_00855	COG0366	Alpha amylase catalytic
APZ20_00860	COG0366	Alpha amylase catalytic
APZ20_00880	COG3328	transposase activity
APZ20_00910	COG0606	chelatase, subunit chli
APZ20_00950	COG1166	arginine decarboxylase activity
APZ20_00965	COG3501	Rhs element vgr protein
APZ20_01020	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_01045	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
APZ20_01060	COG0210	DNA helicase
APZ20_01080	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
APZ20_01115	COG2937	Belongs to the GPAT DAPAT family
APZ20_01135	COG2963	transposase activity
APZ20_01140	COG3328	transposase activity
APZ20_01190	COG1752	Esterase of the alpha-beta hydrolase superfamily
APZ20_01200	COG1119	ATPase activity
APZ20_01215	COG0517	IMP dehydrogenase activity
APZ20_01215	COG1125	glycine betaine transport
APZ20_01230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APZ20_01235	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
APZ20_01240	COG3550	peptidyl-serine autophosphorylation
APZ20_01245	COG1396	sequence-specific DNA binding
APZ20_01265	COG0489	protein tyrosine kinase activity
APZ20_01270	COG2062	phosphohistidine phosphatase, SixA
APZ20_01280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APZ20_01330	COG0174	glutamine synthetase
APZ20_01335	COG0347	Belongs to the P(II) protein family
APZ20_01340	COG0004	ammonium transporteR
APZ20_01345	COG3852	Histidine kinase
APZ20_01350	COG2204	response regulator
APZ20_01355	COG2032	superoxide dismutase activity
APZ20_01360	COG2032	superoxide dismutase activity
APZ20_01405	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
APZ20_01410	COG1074	ATP-dependent DNA helicase activity
APZ20_01420	COG3549	Plasmid maintenance system killer
APZ20_01495	COG1764	response to oxidative stress
APZ20_01500	COG1846	Transcriptional regulator
APZ20_01555	COG3293	Transposase
APZ20_01580	COG2211	Major facilitator Superfamily
APZ20_01600	COG3693	PFAM glycoside hydrolase, family 10
APZ20_01605	COG3693	PFAM glycoside hydrolase, family 10
APZ20_01630	COG0246	Mannitol dehydrogenase
APZ20_01635	COG1472	Belongs to the glycosyl hydrolase 3 family
APZ20_01645	COG4948	Mandelate Racemase Muconate Lactonizing
APZ20_01655	COG3661	Belongs to the glycosyl hydrolase 67 family
APZ20_01670	COG0037	tRNA processing
APZ20_01675	COG2974	May be involved in recombination
APZ20_01695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APZ20_01705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APZ20_01715	COG0805	protein transport
APZ20_01725	COG0519	Catalyzes the synthesis of GMP from XMP
APZ20_01725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APZ20_01740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APZ20_01745	COG0752	glycyl-tRNA synthetase alpha subunit
APZ20_01755	COG0457	Tetratricopeptide repeat
APZ20_01760	COG4771	TonB-dependent receptor
APZ20_01775	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APZ20_01785	COG0697	spore germination
APZ20_01795	COG0523	cobalamin synthesis protein
APZ20_01855	COG1960	acyl-CoA dehydrogenase activity
APZ20_01860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APZ20_01875	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_01930	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
APZ20_01970	COG0084	hydrolase, TatD family'
APZ20_01980	COG0583	DNA-binding transcription factor activity
APZ20_01985	COG2814	Major facilitator Superfamily
APZ20_01995	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APZ20_02000	COG1902	pentaerythritol trinitrate reductase activity
APZ20_02020	COG0745	RESPONSE REGULATOR receiver
APZ20_02025	COG2205	protein histidine kinase activity
APZ20_02030	COG2205	protein histidine kinase activity
APZ20_02040	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APZ20_02045	COG0583	DNA-binding transcription factor activity
APZ20_02075	COG0702	epimerase
APZ20_02080	COG1733	regulation of RNA biosynthetic process
APZ20_02145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APZ20_02160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APZ20_02195	COG2911	Protein conserved in bacteria
APZ20_02200	COG0729	surface antigen
APZ20_02210	COG2963	transposase activity
APZ20_02220	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APZ20_02225	COG3118	belongs to the thioredoxin family
APZ20_02235	COG2884	Cell division ATP-binding protein ftsE
APZ20_02240	COG2177	Part of the ABC transporter FtsEX involved in
APZ20_02245	COG2201	protein-glutamate methylesterase activity
APZ20_02255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APZ20_02265	COG1252	NADH dehydrogenase
APZ20_02290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APZ20_02305	COG4771	TonB-dependent receptor
APZ20_02315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APZ20_02355	COG3386	PFAM SMP-30 Gluconolaconase
APZ20_02370	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APZ20_02405	COG2353	YceI-like domain
APZ20_02495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APZ20_02555	COG3039	Transposase
APZ20_02585	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APZ20_02610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APZ20_02615	COG0318	PFAM AMP-dependent synthetase and ligase
APZ20_02625	COG0596	Alpha beta hydrolase
APZ20_02640	COG3177	Filamentation induced by cAMP protein fic
APZ20_02645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APZ20_02660	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APZ20_02685	COG4191	Histidine kinase
APZ20_02690	COG0028	Belongs to the TPP enzyme family
APZ20_02710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APZ20_02735	COG5383	Protein conserved in bacteria
APZ20_02745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ20_02750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ20_02755	COG1473	amidohydrolase
APZ20_02770	COG3328	transposase activity
APZ20_02870	COG0358	DNA primase activity
APZ20_02875	COG1295	ribonuclease BN
APZ20_02880	COG3293	Transposase
APZ20_02890	COG1610	YqeY-like protein
APZ20_02895	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APZ20_02905	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APZ20_02915	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_02935	COG3293	Transposase
APZ20_02965	COG2133	pyrroloquinoline quinone binding
APZ20_02975	COG4682	membrane
APZ20_02990	COG3293	Transposase
APZ20_03000	COG0531	amino acid
APZ20_03025	COG4948	Mandelate Racemase Muconate Lactonizing
APZ20_03035	COG3023	N-Acetylmuramoyl-L-alanine amidase
APZ20_03040	COG3039	Transposase
APZ20_03050	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
APZ20_03085	COG3039	Transposase
APZ20_03135	COG0183	Belongs to the thiolase family
APZ20_03175	COG3104	oligopeptide transport
APZ20_03200	COG1320	monovalent cation:proton antiporter activity
APZ20_03205	COG2212	antiporter activity
APZ20_03215	COG0651	ATP synthesis coupled electron transport
APZ20_03220	COG1006	Multisubunit Na H antiporter MnhC subunit
APZ20_03225	COG2111	Na H antiporter
APZ20_03225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APZ20_03240	COG3227	Zinc metalloprotease (Elastase)
APZ20_03270	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APZ20_03280	COG0456	acetyltransferase
APZ20_03300	COG2963	transposase activity
APZ20_03315	COG4221	oxidoreductase activity
APZ20_03375	COG0697	spore germination
APZ20_03380	COG4305	rare lipoprotein A
APZ20_03385	COG5297	Belongs to the glycosyl hydrolase family 6
APZ20_03390	COG1113	amino acid transport
APZ20_03400	COG0598	Magnesium transport protein CorA
APZ20_03440	COG3293	Transposase
APZ20_03470	COG0840	transmembrane signaling receptor activity
APZ20_03480	COG5297	Belongs to the glycosyl hydrolase family 6
APZ20_03480	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APZ20_03485	COG0659	secondary active sulfate transmembrane transporter activity
APZ20_03495	COG3706	GGDEF domain
APZ20_03515	COG3293	Transposase
APZ20_03530	COG3275	phosphorelay sensor kinase activity
APZ20_03565	COG1505	serine-type exopeptidase activity
APZ20_03605	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
APZ20_03630	COG0308	aminopeptidase N
APZ20_03635	COG2199	diguanylate cyclase activity
APZ20_03690	COG3039	Transposase
APZ20_03700	COG1077	Cell shape determining protein MreB Mrl
APZ20_03705	COG1792	Involved in formation and maintenance of cell shape
APZ20_03720	COG0772	Belongs to the SEDS family
APZ20_03755	COG3501	Rhs element vgr protein
APZ20_03775	COG2951	lytic endotransglycosylase activity
APZ20_03780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APZ20_03790	COG1686	Belongs to the peptidase S11 family
APZ20_03825	COG1051	belongs to the nudix hydrolase family
APZ20_03825	COG1056	cytidyltransferase-related domain
APZ20_03865	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
APZ20_03870	COG0673	inositol 2-dehydrogenase activity
APZ20_03875	COG2823	Periplasmic or secreted lipoprotein
APZ20_03880	COG4251	negative regulation of phosphorylation
APZ20_03885	COG0784	Response regulator, receiver
APZ20_03890	COG4191	Histidine kinase
APZ20_03895	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APZ20_03915	COG2801	Transposase and inactivated derivatives
APZ20_03925	COG2963	transposase activity
APZ20_03960	COG1609	Transcriptional regulator
APZ20_03965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APZ20_03970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APZ20_03980	COG1215	transferase activity, transferring glycosyl groups
APZ20_03985	COG1649	PFAM Uncharacterised BCR, COG1649
APZ20_03985	COG0726	polysaccharide deacetylase
APZ20_04010	COG3293	Transposase
APZ20_04065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APZ20_04070	COG3039	Transposase
APZ20_04075	COG2963	transposase activity
APZ20_04085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APZ20_04155	COG2205	protein histidine kinase activity
APZ20_04160	COG0745	RESPONSE REGULATOR receiver
APZ20_04210	COG0488	(ABC) transporter
APZ20_04250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APZ20_04250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APZ20_04280	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APZ20_04305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
APZ20_04310	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APZ20_04320	COG2205	protein histidine kinase activity
APZ20_04325	COG0745	RESPONSE REGULATOR receiver
APZ20_04330	COG0277	FAD linked oxidase domain protein
APZ20_04335	COG1988	membrane-bound metal-dependent
APZ20_04375	COG3116	cell division
APZ20_04390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APZ20_04415	COG1181	Belongs to the D-alanine--D-alanine ligase family
APZ20_04420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APZ20_04445	COG4942	peptidase
APZ20_04445	COG1388	LysM domain
APZ20_04460	COG0494	nUDIX hydrolase
APZ20_04475	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
APZ20_04485	COG3321	synthase
APZ20_04485	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_04485	COG0604	alcohol dehydrogenase
APZ20_04535	COG2226	methyltransferase
APZ20_04575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APZ20_04585	COG4106	trans-aconitate 2-methyltransferase activity
APZ20_04590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APZ20_04605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ20_04610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APZ20_04620	COG0667	Aldo Keto reductase
APZ20_04630	COG3293	Transposase
APZ20_04660	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
APZ20_04670	COG2175	clavaminate synthase activity
APZ20_04680	COG4181	ATPase activity
APZ20_04695	COG0642	Histidine kinase
APZ20_04705	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APZ20_04760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APZ20_04775	COG0123	including yeast histone deacetylase and acetoin utilization protein
APZ20_04780	COG2096	Adenosyltransferase
APZ20_04790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APZ20_04795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APZ20_04835	COG0583	DNA-binding transcription factor activity
APZ20_04840	COG0318	PFAM AMP-dependent synthetase and ligase
APZ20_04850	COG1024	Enoyl-CoA hydratase
APZ20_04870	COG3386	PFAM SMP-30 Gluconolaconase
APZ20_04915	COG3293	Transposase
APZ20_04925	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_04955	COG0745	RESPONSE REGULATOR receiver
APZ20_04955	COG3706	GGDEF domain
APZ20_04980	COG2197	response regulator
APZ20_05020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APZ20_05025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APZ20_05030	COG0583	DNA-binding transcription factor activity
APZ20_05035	COG3634	alkyl hydroperoxide reductase activity
APZ20_05045	COG2890	protein-(glutamine-N5) methyltransferase activity
APZ20_05085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APZ20_05085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APZ20_05100	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APZ20_05120	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APZ20_05125	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APZ20_05150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APZ20_05160	COG1404	Belongs to the peptidase S8 family
APZ20_05165	COG1404	Belongs to the peptidase S8 family
APZ20_05170	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APZ20_05200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APZ20_05220	COG0521	Mo-molybdopterin cofactor biosynthetic process
APZ20_05260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APZ20_05275	COG0012	GTP binding
APZ20_05305	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APZ20_05310	COG0250	Participates in transcription elongation, termination and antitermination
APZ20_05345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APZ20_05380	COG0089	rRNA binding
APZ20_05405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APZ20_05410	COG0255	Belongs to the universal ribosomal protein uL29 family
APZ20_05415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APZ20_05425	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APZ20_05435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APZ20_05450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APZ20_05455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APZ20_05460	COG1841	ribosomal large subunit assembly
APZ20_05470	COG0201	protein transport
APZ20_05475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APZ20_05490	COG0202	RNA polymerase activity
APZ20_05495	COG0203	ribosomal protein L17
APZ20_05520	COG2963	transposase activity
APZ20_05565	COG3551	Protein conserved in bacteria
APZ20_05595	COG2194	sulfuric ester hydrolase activity
APZ20_05605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APZ20_05610	COG0745	RESPONSE REGULATOR receiver
APZ20_05615	COG0642	Histidine kinase
APZ20_05625	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
APZ20_05630	COG2894	cell division
APZ20_05655	COG4585	Histidine kinase
APZ20_05660	COG2197	response regulator
APZ20_05675	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
APZ20_05705	COG2963	transposase activity
APZ20_05755	COG3501	Rhs element vgr protein
APZ20_05765	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APZ20_05775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APZ20_05780	COG3501	Rhs element vgr protein
APZ20_05830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APZ20_05835	COG3501	Rhs element vgr protein
APZ20_05890	COG3501	Rhs element vgr protein
APZ20_05895	COG2801	Transposase and inactivated derivatives
APZ20_05900	COG2963	transposase activity
APZ20_05915	COG3501	Rhs element vgr protein
APZ20_05940	COG3501	Rhs element vgr protein
APZ20_05965	COG3501	Rhs element vgr protein
APZ20_05970	COG3501	Rhs element vgr protein
APZ20_06035	COG3501	Rhs element vgr protein
APZ20_06070	COG0732	type I restriction modification DNA specificity domain
APZ20_06075	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APZ20_06085	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
APZ20_06105	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APZ20_06110	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
APZ20_06115	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
APZ20_06120	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APZ20_06205	COG0587	DNA-directed DNA polymerase activity
APZ20_06220	COG1297	OPT oligopeptide transporter protein
APZ20_06235	COG0823	Involved in the tonB-independent uptake of proteins
APZ20_06235	COG1506	peptidase
APZ20_06260	COG2207	Transcriptional regulator
APZ20_06260	COG1917	Cupin 2, conserved barrel domain protein
APZ20_06280	COG0753	catalase activity
APZ20_06295	COG3039	Transposase
APZ20_06320	COG0126	phosphoglycerate kinase activity
APZ20_06330	COG0469	pyruvate kinase activity
APZ20_06335	COG3588	fructose-bisphosphate aldolase
APZ20_06340	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APZ20_06375	COG2205	protein histidine kinase activity
APZ20_06375	COG0784	Response regulator, receiver
APZ20_06375	COG2198	Histidine kinase
APZ20_06405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APZ20_06415	COG2895	sulfate adenylyltransferase (ATP) activity
APZ20_06415	COG0529	Catalyzes the synthesis of activated sulfate
APZ20_06425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ20_06430	COG0308	aminopeptidase N
APZ20_06460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APZ20_06465	COG2272	Belongs to the type-B carboxylesterase lipase family
APZ20_06500	COG1970	mechanosensitive ion channel activity
APZ20_06510	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_06545	COG3273	potassium ion transport
APZ20_06545	COG0471	metal ion transport
APZ20_06590	COG2963	transposase activity
APZ20_06620	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_06625	COG3293	Transposase
APZ20_06650	COG3039	Transposase
APZ20_06665	COG3293	Transposase
APZ20_06675	COG3039	Transposase
APZ20_06720	COG3293	Transposase
APZ20_06735	COG3118	belongs to the thioredoxin family
APZ20_06760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APZ20_06805	COG3039	Transposase
APZ20_06815	COG2968	Membrane
APZ20_06825	COG1530	ribonuclease E activity
APZ20_06830	COG3164	Protein of unknown function
APZ20_06840	COG0312	modulator of DNA gyrase
APZ20_06850	COG0312	modulator of DNA gyrase
APZ20_06870	COG0142	geranyltranstransferase activity
APZ20_06880	COG0037	tRNA processing
APZ20_06885	COG1785	Belongs to the alkaline phosphatase family
APZ20_06890	COG1301	dicarboxylic acid transport
APZ20_06905	COG0791	NLP P60 protein
APZ20_06910	COG0791	NLP P60 protein
APZ20_06915	COG1047	Peptidyl-prolyl cis-trans
APZ20_06920	COG2311	Membrane
APZ20_06925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APZ20_06960	COG0489	protein tyrosine kinase activity
APZ20_06980	COG0412	Dienelactone hydrolase
APZ20_06990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APZ20_07010	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_07015	COG0433	COG0433 Predicted ATPase
APZ20_07035	COG2890	protein-(glutamine-N5) methyltransferase activity
APZ20_07045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APZ20_07050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APZ20_07080	COG0133	tryptophan synthase activity
APZ20_07125	COG3293	Transposase
APZ20_07160	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APZ20_07180	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
APZ20_07185	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
APZ20_07190	COG1034	ATP synthesis coupled electron transport
APZ20_07195	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APZ20_07210	COG0713	ATP synthesis coupled electron transport
APZ20_07225	COG1007	ATP synthesis coupled electron transport
APZ20_07240	COG0195	Participates in both transcription termination and antitermination
APZ20_07260	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APZ20_07295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APZ20_07300	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APZ20_07310	COG2095	MarC family integral membrane protein
APZ20_07320	COG1611	Belongs to the LOG family
APZ20_07325	COG3039	Transposase
APZ20_07365	COG4969	Belongs to the N-Me-Phe pilin family
APZ20_07370	COG0556	nucleotide-excision repair
APZ20_07395	COG2963	transposase activity
APZ20_07410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APZ20_07415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APZ20_07420	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APZ20_07425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APZ20_07435	COG0776	regulation of translation
APZ20_07480	COG0438	transferase activity, transferring glycosyl groups
APZ20_07485	COG0438	transferase activity, transferring glycosyl groups
APZ20_07610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APZ20_07635	COG0784	Response regulator, receiver
APZ20_07635	COG4191	Histidine kinase
APZ20_07655	COG0552	protein localization to endoplasmic reticulum
APZ20_07665	COG3938	Belongs to the proline racemase family
APZ20_07670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APZ20_07685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APZ20_07695	COG0006	proline dipeptidase activity
APZ20_07710	COG0531	amino acid
APZ20_07760	COG4206	TonB-dependent receptor
APZ20_07785	COG4206	TonB-dependent receptor
APZ20_07790	COG3328	transposase activity
APZ20_07840	COG0746	molybdenum cofactor guanylyltransferase activity
APZ20_07865	COG1648	precorrin-2 dehydrogenase activity
APZ20_07865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APZ20_07935	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APZ20_07965	COG3293	Transposase
APZ20_07980	COG1530	ribonuclease E activity
APZ20_07990	COG3064	Membrane
APZ20_07995	COG0428	transporter
APZ20_08000	COG0428	transporter
APZ20_08025	COG2801	Transposase and inactivated derivatives
APZ20_08080	COG3039	Transposase
APZ20_08140	COG3039	Transposase
APZ20_08150	COG3501	Rhs element vgr protein
APZ20_08185	COG0631	protein serine/threonine phosphatase activity
APZ20_08190	COG0515	serine threonine protein kinase
APZ20_08215	COG1858	cytochrome C peroxidase
APZ20_08225	COG4644	lycopene metabolic process
APZ20_08240	COG2963	transposase activity
APZ20_08270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ20_08275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ20_08290	COG2201	protein-glutamate methylesterase activity
APZ20_08320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APZ20_08340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APZ20_08355	COG1595	DNA-templated transcription, initiation
APZ20_08405	COG2244	polysaccharide biosynthetic process
APZ20_08435	COG2264	protein methyltransferase activity
APZ20_08445	COG0438	transferase activity, transferring glycosyl groups
APZ20_08460	COG1136	(ABC) transporter
APZ20_08465	COG1132	(ABC) transporter
APZ20_08470	COG0477	Major facilitator Superfamily
APZ20_08475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APZ20_08490	COG1253	flavin adenine dinucleotide binding
APZ20_08500	COG0306	phosphate transporter
APZ20_08555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APZ20_08570	COG2840	Smr protein MutS2
APZ20_08585	COG1238	metal cluster binding
APZ20_08600	COG1534	Rna-binding protein
APZ20_08610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APZ20_08615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APZ20_08625	COG1923	regulation of RNA biosynthetic process
APZ20_08630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APZ20_08635	COG1546	Belongs to the CinA family
APZ20_08655	COG2137	regulation of response to DNA damage stimulus
APZ20_08665	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APZ20_08685	COG0305	Participates in initiation and elongation during chromosome replication
APZ20_08690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APZ20_08710	COG1741	Belongs to the pirin family
APZ20_08715	COG0583	DNA-binding transcription factor activity
APZ20_08745	COG0351	phosphomethylpyrimidine kinase
APZ20_08755	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
APZ20_08760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APZ20_08775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APZ20_08785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
APZ20_08790	COG3734	2-keto-3-deoxy-galactonokinase
APZ20_08805	COG0800	Aldolase
APZ20_08820	COG1501	Belongs to the glycosyl hydrolase 31 family
APZ20_08835	COG1070	Carbohydrate kinase
APZ20_08845	COG0477	Major facilitator Superfamily
APZ20_08915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APZ20_08920	COG2258	MOSC domain
APZ20_08925	COG3293	Transposase
APZ20_08935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APZ20_08940	COG0505	Belongs to the CarA family
APZ20_08950	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APZ20_08955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APZ20_08965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APZ20_09005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APZ20_09025	COG2198	Histidine kinase
APZ20_09025	COG2205	protein histidine kinase activity
APZ20_09025	COG0784	Response regulator, receiver
APZ20_09030	COG1024	Enoyl-CoA hydratase
APZ20_09035	COG0318	PFAM AMP-dependent synthetase and ligase
APZ20_09065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APZ20_09090	COG0840	transmembrane signaling receptor activity
APZ20_09110	COG0835	chemotaxis
APZ20_09120	COG0840	transmembrane signaling receptor activity
APZ20_09125	COG0840	transmembrane signaling receptor activity
APZ20_09130	COG0840	transmembrane signaling receptor activity
APZ20_09135	COG0840	transmembrane signaling receptor activity
APZ20_09140	COG0840	transmembrane signaling receptor activity
APZ20_09150	COG3293	Transposase
APZ20_09160	COG0840	transmembrane signaling receptor activity
APZ20_09190	COG0745	RESPONSE REGULATOR receiver
APZ20_09200	COG0835	chemotaxis
APZ20_09205	COG1192	Involved in chromosome partitioning
APZ20_09210	COG1360	Flagellar Motor Protein
APZ20_09215	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APZ20_09235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APZ20_09245	COG4771	TonB-dependent receptor
APZ20_09305	COG3501	Rhs element vgr protein
APZ20_09370	COG3039	Transposase
APZ20_09420	COG1862	Preprotein translocase
APZ20_09430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APZ20_09460	COG3328	transposase activity
APZ20_09475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APZ20_09485	COG0704	Plays a role in the regulation of phosphate uptake
APZ20_09500	COG0573	inorganic phosphate transmembrane transporter activity
APZ20_09505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APZ20_09525	COG3293	Transposase
APZ20_09545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APZ20_09555	COG1024	Enoyl-CoA hydratase
APZ20_09565	COG0494	nUDIX hydrolase
APZ20_09630	COG0667	Aldo Keto reductase
APZ20_09640	COG2925	Exonuclease
APZ20_09665	COG0288	reversible hydration of carbon dioxide
APZ20_09700	COG0316	Belongs to the HesB IscA family
APZ20_09725	COG3115	cell septum assembly
APZ20_09740	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
APZ20_09760	COG2963	transposase activity
APZ20_09780	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
APZ20_09790	COG2986	histidine ammonia-lyase
APZ20_09840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APZ20_09850	COG0077	Prephenate dehydratase
APZ20_09850	COG1605	Chorismate mutase
APZ20_09865	COG2963	transposase activity
APZ20_09885	COG4566	intracellular signal transduction
APZ20_09930	COG0860	N-Acetylmuramoyl-L-alanine amidase
APZ20_09955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APZ20_09990	COG1472	Belongs to the glycosyl hydrolase 3 family
APZ20_10000	COG4251	negative regulation of phosphorylation
APZ20_10000	COG3706	GGDEF domain
APZ20_10000	COG5001	Diguanylate cyclase
APZ20_10000	COG2203	Gaf domain
APZ20_10085	COG0386	Belongs to the glutathione peroxidase family
APZ20_10145	COG3706	GGDEF domain
APZ20_10165	COG3293	Transposase
APZ20_10175	COG1247	-acetyltransferase
APZ20_10200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APZ20_10225	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APZ20_10250	COG0431	NADPH-dependent FMN reductase
APZ20_10255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APZ20_10260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APZ20_10280	COG0784	Response regulator, receiver
APZ20_10280	COG2205	protein histidine kinase activity
APZ20_10280	COG5002	protein histidine kinase activity
APZ20_10305	COG3293	Transposase
APZ20_10320	COG0800	Aldolase
APZ20_10325	COG0129	dihydroxy-acid dehydratase activity
APZ20_10330	COG0363	glucosamine-6-phosphate deaminase activity
APZ20_10340	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APZ20_10350	COG0354	folic acid binding
APZ20_10360	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
APZ20_10375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APZ20_10390	COG4591	ABC-type transport system involved in lipoprotein release permease component
APZ20_10415	COG0811	peptide transport
APZ20_10440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APZ20_10520	COG2201	protein-glutamate methylesterase activity
APZ20_10540	COG3293	Transposase
APZ20_10585	COG3293	Transposase
APZ20_10655	COG0140	phosphoribosyl-ATP diphosphatase activity
APZ20_10655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APZ20_10710	COG0124	histidyl-tRNA synthetase
APZ20_10725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APZ20_10760	COG1012	belongs to the aldehyde dehydrogenase family
APZ20_10785	COG0697	spore germination
APZ20_10790	COG1794	racemase activity, acting on amino acids and derivatives
APZ20_10805	COG0671	phosphoesterase, PA-phosphatase related
APZ20_10820	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
APZ20_10830	COG2183	response to ionizing radiation
APZ20_10840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APZ20_10840	COG0723	plastoquinol--plastocyanin reductase activity
APZ20_10855	COG3243	poly(R)-hydroxyalkanoic acid synthase
APZ20_10865	COG1183	phosphatidylcholine synthase activity
APZ20_10870	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_10895	COG0668	transmembrane transport
APZ20_10905	COG0590	tRNA wobble adenosine to inosine editing
APZ20_10910	COG1321	iron dependent repressor
APZ20_10915	COG1914	H( )-stimulated, divalent metal cation uptake system
APZ20_10930	COG0583	DNA-binding transcription factor activity
APZ20_10935	COG0583	DNA-binding transcription factor activity
APZ20_10955	COG0583	DNA-binding transcription factor activity
APZ20_10960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APZ20_11015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APZ20_11015	COG0475	glutathione-regulated potassium exporter activity
APZ20_11020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APZ20_11030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APZ20_11035	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APZ20_11050	COG0539	negative regulation of cytoplasmic translation
APZ20_11060	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APZ20_11070	COG2957	Belongs to the agmatine deiminase family
APZ20_11075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APZ20_11100	COG0395	ABC-type sugar transport system, permease component
APZ20_11105	COG1175	transmembrane transport
APZ20_11135	COG2350	Protein conserved in bacteria
APZ20_11140	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APZ20_11145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APZ20_11150	COG1187	pseudouridine synthase activity
APZ20_11175	COG0436	Aminotransferase
APZ20_11240	COG0277	FAD linked oxidase domain protein
APZ20_11245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APZ20_11255	COG0531	amino acid
APZ20_11260	COG0531	amino acid
APZ20_11295	COG3039	Transposase
APZ20_11305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APZ20_11340	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_11375	COG0303	'Molybdopterin
APZ20_11385	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APZ20_11395	COG1426	Protein conserved in bacteria
APZ20_11410	COG0105	UTP biosynthetic process
APZ20_11420	COG1024	Enoyl-CoA hydratase
APZ20_11420	COG1250	3-hydroxyacyl-CoA dehydrogenase
APZ20_11425	COG0183	Belongs to the thiolase family
APZ20_11430	COG0038	chloride channel
APZ20_11450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APZ20_11470	COG1674	ftsk spoiiie
APZ20_11475	COG0492	ferredoxin-NADP+ reductase activity
APZ20_11500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APZ20_11505	COG0542	response to heat
APZ20_11510	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APZ20_11545	COG5001	Diguanylate cyclase
APZ20_11550	COG4585	Histidine kinase
APZ20_11560	COG5002	protein histidine kinase activity
APZ20_11580	COG0835	chemotaxis
APZ20_11580	COG0784	Response regulator, receiver
APZ20_11590	COG1558	bacterial-type flagellum-dependent cell motility
APZ20_11595	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
APZ20_11600	COG1749	Flagellar hook protein flgE
APZ20_11605	COG4787	bacterial-type flagellum-dependent cell motility
APZ20_11615	COG4786	Flagellar basal body rod
APZ20_11645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APZ20_11650	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
APZ20_11680	COG2201	protein-glutamate methylesterase activity
APZ20_11685	COG2204	response regulator
APZ20_11700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APZ20_11710	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_11745	COG1677	Flagellar hook-basal body complex protein FliE
APZ20_11795	COG3190	flagellar
APZ20_11805	COG1987	bacterial-type flagellum assembly
APZ20_11810	COG1684	flagellar biosynthetic protein fliR
APZ20_11815	COG3300	MHYT domain
APZ20_11815	COG5001	Diguanylate cyclase
APZ20_11820	COG3300	MHYT domain
APZ20_11820	COG5001	Diguanylate cyclase
APZ20_11835	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APZ20_11845	COG0455	bacterial-type flagellum organization
APZ20_11865	COG2198	Histidine kinase
APZ20_11865	COG0643	Histidine kinase
APZ20_11880	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_11925	COG3039	Transposase
APZ20_12010	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APZ20_12015	COG4988	ABC transporter
APZ20_12025	COG1271	oxidase subunit
APZ20_12030	COG1294	oxidase, subunit
APZ20_12090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APZ20_12095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APZ20_12105	COG0137	argininosuccinate synthase activity
APZ20_12110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APZ20_12125	COG2166	iron-sulfur cluster assembly
APZ20_12140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APZ20_12155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APZ20_12165	COG4302	ethanolamine ammonia-lyase activity
APZ20_12185	COG3039	Transposase
APZ20_12205	COG4677	pectinesterase activity
APZ20_12240	COG0402	S-adenosylhomocysteine deaminase activity
APZ20_12255	COG1509	lysine 2,3-aminomutase activity
APZ20_12260	COG5001	Diguanylate cyclase
APZ20_12260	COG3300	MHYT domain
APZ20_12275	COG0483	inositol monophosphate 1-phosphatase activity
APZ20_12305	COG0513	Belongs to the DEAD box helicase family
APZ20_12315	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APZ20_12325	COG0625	glutathione transferase activity
APZ20_12340	COG4681	YaeQ
APZ20_12345	COG2081	HI0933 family
APZ20_12365	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_12390	COG0860	N-Acetylmuramoyl-L-alanine amidase
APZ20_12395	COG0802	atpase or kinase
APZ20_12400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APZ20_12400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APZ20_12405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APZ20_12425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APZ20_12485	COG3039	Transposase
APZ20_12490	COG3328	transposase activity
APZ20_12520	COG2969	positive regulation of protein catabolic process
APZ20_12525	COG0625	glutathione transferase activity
APZ20_12530	COG2857	Cytochrome c1
APZ20_12535	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APZ20_12540	COG0723	plastoquinol--plastocyanin reductase activity
APZ20_12545	COG0741	lytic transglycosylase activity
APZ20_12570	COG1702	phosphate starvation-inducible protein PhoH
APZ20_12590	COG4535	Mg2 and Co2 transporter CorC
APZ20_12605	COG1012	belongs to the aldehyde dehydrogenase family
APZ20_12615	COG1177	transmembrane transport
APZ20_12660	COG0174	glutamine synthetase
APZ20_12665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APZ20_12670	COG3706	GGDEF domain
APZ20_12670	COG0745	RESPONSE REGULATOR receiver
APZ20_12675	COG0477	Major facilitator Superfamily
APZ20_12685	COG0243	molybdopterin cofactor binding
APZ20_12710	COG1121	(ABC) transporter
APZ20_12720	COG2733	membrane
APZ20_12725	COG0784	Response regulator, receiver
APZ20_12725	COG2205	protein histidine kinase activity
APZ20_12725	COG5002	protein histidine kinase activity
APZ20_12735	COG3039	Transposase
APZ20_12740	COG2902	Dehydrogenase
APZ20_12750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ20_12755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ20_12775	COG1609	Transcriptional regulator
APZ20_12780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APZ20_12780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ20_12785	COG1105	Belongs to the carbohydrate kinase PfkB family
APZ20_12790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APZ20_12790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APZ20_12805	COG3039	Transposase
APZ20_12845	COG3501	Rhs element vgr protein
APZ20_12865	COG3501	Rhs element vgr protein
APZ20_12915	COG3293	Transposase
APZ20_12930	COG0405	Gamma-glutamyltransferase
APZ20_12935	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APZ20_12955	COG0742	ribosomal rna small subunit methyltransferase
APZ20_13025	COG0583	DNA-binding transcription factor activity
APZ20_13035	COG3039	Transposase
APZ20_13060	COG2963	transposase activity
APZ20_13065	COG2801	Transposase and inactivated derivatives
APZ20_13105	COG1278	Cold shock
APZ20_13155	COG3039	Transposase
APZ20_13165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APZ20_13175	COG0557	exoribonuclease II activity
APZ20_13195	COG1960	acyl-CoA dehydrogenase activity
APZ20_13205	COG1410	methionine synthase
APZ20_13205	COG0646	methionine synthase
APZ20_13210	COG0646	methionine synthase
APZ20_13210	COG1410	methionine synthase
APZ20_13220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ20_13260	COG0386	Belongs to the glutathione peroxidase family
APZ20_13270	COG1725	Transcriptional regulator
APZ20_13275	COG1131	(ABC) transporter
APZ20_13315	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_13325	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_13335	COG3293	Transposase
APZ20_13375	COG2850	peptidyl-arginine hydroxylation
APZ20_13410	COG1132	(ABC) transporter
APZ20_13415	COG0583	DNA-binding transcription factor activity
APZ20_13430	COG1605	Chorismate mutase
APZ20_13430	COG0287	Prephenate dehydrogenase
APZ20_13435	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
APZ20_13460	COG0497	DNA recombination
APZ20_13470	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APZ20_13475	COG2914	Belongs to the UPF0125 (RnfH) family
APZ20_13485	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APZ20_13505	COG1960	acyl-CoA dehydrogenase activity
APZ20_13535	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_13555	COG3293	Transposase
APZ20_13570	COG2814	Major facilitator Superfamily
APZ20_13575	COG1566	PFAM secretion protein HlyD family protein
APZ20_13590	COG2207	Transcriptional regulator
APZ20_13620	COG4774	siderophore transport
APZ20_13635	COG0367	asparagine synthase
APZ20_13650	COG1393	Belongs to the ArsC family
APZ20_13670	COG0024	Methionine aminopeptidase
APZ20_13735	COG0575	Belongs to the CDS family
APZ20_13745	COG0750	zinc metalloprotease
APZ20_13795	COG4771	TonB-dependent receptor
APZ20_13800	COG1131	(ABC) transporter
APZ20_13900	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APZ20_13915	COG2040	homocysteine
APZ20_13920	COG0833	amino acid
APZ20_13950	COG2878	Part of a membrane complex involved in electron transport
APZ20_13970	COG1595	DNA-templated transcription, initiation
APZ20_13995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APZ20_14010	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APZ20_14015	COG0251	oxidation-reduction process
APZ20_14025	COG0392	lysyltransferase activity
APZ20_14025	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APZ20_14055	COG2814	Major facilitator Superfamily
APZ20_14060	COG1902	pentaerythritol trinitrate reductase activity
APZ20_14070	COG2824	Alkylphosphonate utilization operon protein PhnA
APZ20_14085	COG1047	Peptidyl-prolyl cis-trans
APZ20_14120	COG3039	Transposase
APZ20_14125	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APZ20_14135	COG1451	nucleotide metabolic process
APZ20_14150	COG0183	Belongs to the thiolase family
APZ20_14165	COG3706	GGDEF domain
APZ20_14165	COG0745	RESPONSE REGULATOR receiver
APZ20_14180	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
APZ20_14180	COG1793	dna ligase
APZ20_14190	COG1793	dna ligase
APZ20_14195	COG1201	RNA secondary structure unwinding
APZ20_14215	COG1278	Cold shock
APZ20_14220	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APZ20_14235	COG3046	protein related to deoxyribodipyrimidine photolyase
APZ20_14240	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
APZ20_14245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
APZ20_14315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APZ20_14330	COG1250	3-hydroxyacyl-CoA dehydrogenase
APZ20_14330	COG1024	Enoyl-CoA hydratase
APZ20_14350	COG1024	Enoyl-CoA hydratase
APZ20_14355	COG1960	acyl-CoA dehydrogenase activity
APZ20_14380	COG3867	Arabinogalactan endo-beta-1,4-galactanase
APZ20_14415	COG3293	Transposase
APZ20_14440	COG2353	YceI-like domain
APZ20_14450	COG2353	YceI-like domain
APZ20_14460	COG1760	l-serine dehydratase
APZ20_14470	COG0626	cystathionine gamma-synthase activity
APZ20_14475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APZ20_14480	COG0739	heme binding
APZ20_14490	COG1272	protein, Hemolysin III
APZ20_14505	COG0517	IMP dehydrogenase activity
APZ20_14505	COG0516	GMP reductase activity
APZ20_14510	COG0463	Glycosyl transferase, family 2
APZ20_14520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APZ20_14530	COG4771	TonB-dependent receptor
APZ20_14535	COG1309	transcriptional regulator
APZ20_14545	COG1960	acyl-CoA dehydrogenase activity
APZ20_14585	COG0330	HflC and HflK could
APZ20_14595	COG3956	TIGRFAM MazG family protein
APZ20_14605	COG0494	nUDIX hydrolase
APZ20_14615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APZ20_14620	COG0837	glucose binding
APZ20_14635	COG1388	LysM domain
APZ20_14635	COG3858	chitin binding
APZ20_14640	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APZ20_14650	COG1472	Belongs to the glycosyl hydrolase 3 family
APZ20_14710	COG3537	Alpha-1,2-mannosidase
APZ20_14750	COG3142	Participates in the control of copper homeostasis
APZ20_14755	COG1446	asparaginase
APZ20_14800	COG0840	transmembrane signaling receptor activity
APZ20_14805	COG0835	chemotaxis
APZ20_14820	COG0189	ligase activity
APZ20_14830	COG1397	ADP-ribosylglycohydrolase
APZ20_14840	COG1199	ATP-dependent helicase activity
APZ20_14850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APZ20_14865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APZ20_14880	COG0535	radical SAM domain protein
APZ20_14885	COG0535	radical SAM domain protein
APZ20_14900	COG0837	glucose binding
APZ20_14905	COG0837	glucose binding
APZ20_14910	COG0837	glucose binding
APZ20_14920	COG1643	Atp-dependent helicase
APZ20_14925	COG0783	Belongs to the Dps family
APZ20_14930	COG0514	ATP-dependent DNA helicase (RecQ)
APZ20_14960	COG3293	Transposase
APZ20_14975	COG0602	queuosine metabolic process
APZ20_14985	COG2885	chlorophyll binding
APZ20_15000	COG0848	biopolymer transport protein
APZ20_15010	COG0824	Thioesterase
APZ20_15110	COG2963	transposase activity
APZ20_15120	COG2801	Transposase and inactivated derivatives
APZ20_15145	COG2801	Transposase and inactivated derivatives
APZ20_15150	COG2963	transposase activity
APZ20_15170	COG3039	Transposase
APZ20_15175	COG3039	Transposase
APZ20_15190	COG3039	Transposase
APZ20_15225	COG3328	transposase activity
APZ20_15235	COG3209	COG3209 Rhs family protein
APZ20_15245	COG3501	Rhs element vgr protein
APZ20_15255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APZ20_15260	COG1845	cytochrome c oxidase, subunit III
APZ20_15265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APZ20_15295	COG0196	riboflavin kinase activity
APZ20_15300	COG0728	peptidoglycan biosynthetic process
APZ20_15305	COG0268	Binds directly to 16S ribosomal RNA
APZ20_15325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APZ20_15330	COG0824	Thioesterase
APZ20_15345	COG1946	Acyl-CoA thioesterase
APZ20_15355	COG1595	DNA-templated transcription, initiation
APZ20_15410	COG1877	trehalose-phosphatase activity
APZ20_15415	COG3387	PFAM Glycoside hydrolase 15-related
APZ20_15440	COG0564	pseudouridine synthase activity
APZ20_15445	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APZ20_15450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APZ20_15450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
APZ20_15460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APZ20_15480	COG2184	nucleotidyltransferase activity
APZ20_15500	COG2194	sulfuric ester hydrolase activity
APZ20_15505	COG4969	Belongs to the N-Me-Phe pilin family
APZ20_15515	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
APZ20_15535	COG3039	Transposase
APZ20_15550	COG3039	Transposase
APZ20_15560	COG3293	Transposase
APZ20_15570	COG1132	(ABC) transporter
APZ20_15600	COG0745	RESPONSE REGULATOR receiver
APZ20_15605	COG5000	phosphorelay sensor kinase activity
APZ20_15605	COG5002	protein histidine kinase activity
APZ20_15610	COG0475	glutathione-regulated potassium exporter activity
APZ20_15635	COG1187	pseudouridine synthase activity
APZ20_15640	COG5002	protein histidine kinase activity
APZ20_15640	COG5001	Diguanylate cyclase
APZ20_15760	COG0415	Belongs to the DNA photolyase family
APZ20_15765	COG0305	Participates in initiation and elongation during chromosome replication
APZ20_15775	COG0367	asparagine synthase
APZ20_15800	COG1960	acyl-CoA dehydrogenase activity
APZ20_15815	COG0084	hydrolase, TatD family'
APZ20_15820	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APZ20_15860	COG0735	belongs to the Fur family
APZ20_15890	COG3039	Transposase
APZ20_15920	COG3039	Transposase
APZ20_15945	COG2205	protein histidine kinase activity
APZ20_15955	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APZ20_15965	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APZ20_15975	COG2198	Histidine kinase
APZ20_15975	COG0643	Histidine kinase
APZ20_15980	COG0840	transmembrane signaling receptor activity
APZ20_15985	COG0835	chemotaxis
APZ20_15990	COG2199	diguanylate cyclase activity
APZ20_15990	COG2200	EAL domain
APZ20_15990	COG2202	Pas domain
APZ20_15995	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APZ20_16010	COG3590	peptidase
APZ20_16020	COG0588	phosphoglycerate mutase activity
APZ20_16025	COG1515	deoxyribonuclease V activity
APZ20_16035	COG1741	Belongs to the pirin family
APZ20_16085	COG3501	Rhs element vgr protein
APZ20_16095	COG3039	Transposase
APZ20_16115	COG3501	Rhs element vgr protein
APZ20_16135	COG3501	Rhs element vgr protein
APZ20_16145	COG1741	Belongs to the pirin family
APZ20_16150	COG1966	Carbon starvation protein
APZ20_16155	COG2879	small protein
APZ20_16180	COG0604	alcohol dehydrogenase
APZ20_16180	COG3321	synthase
APZ20_16180	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_16185	COG2203	Gaf domain
APZ20_16185	COG3706	GGDEF domain
APZ20_16185	COG4251	negative regulation of phosphorylation
APZ20_16185	COG5001	Diguanylate cyclase
APZ20_16195	COG0629	single-stranded DNA binding
APZ20_16200	COG0142	geranyltranstransferase activity
APZ20_16230	COG0527	aspartate kinase activity
APZ20_16240	COG0384	phenazine biosynthesis protein PhzF
APZ20_16245	COG3293	Transposase
APZ20_16260	COG1764	response to oxidative stress
APZ20_16290	COG0519	Catalyzes the synthesis of GMP from XMP
APZ20_16315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APZ20_16370	COG1959	2 iron, 2 sulfur cluster binding
APZ20_16375	COG0719	Fe-S assembly protein
APZ20_16380	COG0396	ATPase activity
APZ20_16385	COG0719	Fe-S assembly protein
APZ20_16390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APZ20_16405	COG3039	Transposase
APZ20_16410	COG2963	transposase activity
APZ20_16415	COG2801	Transposase and inactivated derivatives
APZ20_16445	COG3328	transposase activity
APZ20_16455	COG2963	transposase activity
APZ20_16480	COG0326	Molecular chaperone. Has ATPase activity
APZ20_16485	COG2207	Transcriptional regulator
APZ20_16505	COG0657	acetylesterase activity
APZ20_16505	COG2755	lipolytic protein G-D-S-L family
APZ20_16530	COG0488	(ABC) transporter
APZ20_16570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APZ20_16570	COG4651	solute:proton antiporter activity
APZ20_16575	COG2801	Transposase and inactivated derivatives
APZ20_16585	COG4772	TonB-dependent receptor
APZ20_16595	COG4264	IucA IucC family
APZ20_16600	COG2814	Major facilitator Superfamily
APZ20_16610	COG0019	diaminopimelate decarboxylase activity
APZ20_16660	COG4206	TonB-dependent receptor
APZ20_16675	COG2963	transposase activity
APZ20_16690	COG0542	response to heat
APZ20_16735	COG0534	Mate efflux family protein
APZ20_16775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APZ20_16785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APZ20_16840	COG1555	photosystem II stabilization
APZ20_16845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APZ20_16860	COG3178	'Phosphotransferase
APZ20_16865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APZ20_16875	COG0628	permease
APZ20_16900	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APZ20_16925	COG0271	Belongs to the BolA IbaG family
APZ20_16935	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APZ20_16945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
APZ20_16950	COG1137	ATPase activity
APZ20_16965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ20_16985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ20_16990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APZ20_16995	COG2239	Acts as a magnesium transporter
APZ20_17005	COG1294	oxidase, subunit
APZ20_17010	COG1271	oxidase subunit
APZ20_17020	COG1113	amino acid transport
APZ20_17030	COG2197	response regulator
APZ20_17035	COG0531	amino acid
APZ20_17090	COG0789	Transcriptional regulator
APZ20_17115	COG0754	glutathionylspermidine amidase activity
APZ20_17140	COG1842	Phage shock protein A
APZ20_17170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APZ20_17205	COG2201	protein-glutamate methylesterase activity
APZ20_17250	COG2201	protein-glutamate methylesterase activity
APZ20_17275	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APZ20_17295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APZ20_17330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APZ20_17335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APZ20_17370	COG3039	Transposase
APZ20_17390	COG0745	RESPONSE REGULATOR receiver
APZ20_17395	COG2205	protein histidine kinase activity
APZ20_17410	COG3293	Transposase
APZ20_17415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APZ20_17460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APZ20_17460	COG3453	Protein conserved in bacteria
APZ20_17465	COG0725	ABC transporter, periplasmic molybdate-binding protein
APZ20_17470	COG4149	molybdate abc transporter
APZ20_17475	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APZ20_17495	COG0642	Histidine kinase
APZ20_17500	COG0745	RESPONSE REGULATOR receiver
APZ20_17510	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_17520	COG1022	Amp-dependent synthetase and ligase
APZ20_17545	COG1376	ErfK ybiS ycfS ynhG family protein
APZ20_17550	COG0739	heme binding
APZ20_17555	COG4773	Receptor
APZ20_17560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APZ20_17565	COG1301	dicarboxylic acid transport
APZ20_17580	COG2304	oxidoreductase activity
APZ20_17600	COG0714	Associated with various cellular activities
APZ20_17650	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APZ20_17670	COG0254	rRNA binding
APZ20_17680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APZ20_17690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APZ20_17710	COG1561	YicC-like family, N-terminal region
APZ20_17730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APZ20_17755	COG0006	proline dipeptidase activity
APZ20_17775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APZ20_17785	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APZ20_17795	COG2912	Transglutaminase-like superfamily
APZ20_17800	COG1773	rubredoxin
APZ20_17805	COG0352	thiamine-phosphate diphosphorylase activity
APZ20_17830	COG2801	Transposase and inactivated derivatives
APZ20_17835	COG2963	transposase activity
APZ20_17840	COG0280	phosphate acetyltransferase
APZ20_17840	COG0281	malic enzyme
APZ20_17855	COG4191	Histidine kinase
APZ20_17870	COG0583	DNA-binding transcription factor activity
APZ20_17885	COG2197	response regulator
APZ20_17890	COG1840	ABC-type Fe3 transport system, periplasmic component
APZ20_17895	COG0642	Histidine kinase
APZ20_17910	COG2851	Citrate transporter
APZ20_17915	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_17920	COG1609	Transcriptional regulator
APZ20_17970	COG0726	polysaccharide deacetylase
APZ20_17975	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APZ20_18010	COG0242	peptide deformylase activity
APZ20_18025	COG0714	Associated with various cellular activities
APZ20_18045	COG0537	adenosine 5'-monophosphoramidase activity
APZ20_18070	COG0314	molybdopterin synthase activity
APZ20_18075	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APZ20_18090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APZ20_18095	COG1234	tRNA 3'-trailer cleavage
APZ20_18105	COG0859	PFAM glycosyl transferase family 9
APZ20_18115	COG0582	viral genome integration into host DNA
APZ20_18155	COG3501	Rhs element vgr protein
APZ20_18185	COG0631	protein serine/threonine phosphatase activity
APZ20_18190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APZ20_18215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APZ20_18250	COG0740	serine-type endopeptidase activity
APZ20_18255	COG0544	peptidyl-prolyl cis-trans isomerase activity
APZ20_18280	COG2963	transposase activity
APZ20_18310	COG0473	3-isopropylmalate dehydrogenase activity
APZ20_18340	COG4783	chaperone-mediated protein folding
APZ20_18355	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APZ20_18365	COG0438	transferase activity, transferring glycosyl groups
APZ20_18370	COG0671	phosphoesterase, PA-phosphatase related
APZ20_18385	COG2833	Protein of unknown function (DUF455)
APZ20_18405	COG0285	dihydrofolate synthase activity
APZ20_18410	COG0406	alpha-ribazole phosphatase activity
APZ20_18440	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APZ20_18445	COG4208	sulfate ABC transporter
APZ20_18450	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APZ20_18455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APZ20_18460	COG0156	8-amino-7-oxononanoate synthase activity
APZ20_18490	COG0446	pyridine nucleotide-disulphide oxidoreductase
APZ20_18490	COG1902	pentaerythritol trinitrate reductase activity
APZ20_18505	COG3293	Transposase
APZ20_18540	COG0584	glycerophosphoryl diester phosphodiesterase
APZ20_18550	COG3293	Transposase
APZ20_18570	COG3039	Transposase
APZ20_18580	COG0625	glutathione transferase activity
APZ20_18590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APZ20_18615	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
APZ20_18635	COG2963	transposase activity
APZ20_18685	COG2963	transposase activity
APZ20_18710	COG3293	Transposase
APZ20_18735	COG3293	Transposase
APZ20_18760	COG3781	membrane
APZ20_18770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APZ20_18810	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APZ20_18920	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APZ20_18925	COG1538	Outer membrane efflux protein
APZ20_18930	COG1519	Transferase
APZ20_18935	COG1560	Kdo2-lipid A biosynthetic process
APZ20_18975	COG0308	aminopeptidase N
APZ20_18980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APZ20_18990	COG0330	HflC and HflK could
APZ20_18995	COG0330	HflC and HflK could
APZ20_19015	COG0678	peroxiredoxin activity
APZ20_19080	COG3829	transcription factor binding
APZ20_19105	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APZ20_19110	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APZ20_19125	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_19150	COG1399	metal-binding, possibly nucleic acid-binding protein
APZ20_19190	COG1518	maintenance of DNA repeat elements
APZ20_19195	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APZ20_19230	COG2188	Transcriptional regulator
APZ20_19240	COG1450	Type ii and iii secretion system protein
APZ20_19255	COG3166	PFAM Fimbrial assembly family protein
APZ20_19260	COG3156	type II secretion system protein K
APZ20_19265	COG4795	General secretion pathway protein
APZ20_19270	COG2165	general secretion pathway protein
APZ20_19275	COG4970	Tfp pilus assembly protein FimT
APZ20_19280	COG2165	general secretion pathway protein
APZ20_19285	COG1459	type II secretion system
APZ20_19295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APZ20_19305	COG5295	Hep Hag repeat protein
APZ20_19310	COG0047	phosphoribosylformylglycinamidine synthase activity
APZ20_19310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APZ20_19315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APZ20_19320	COG4974	Belongs to the 'phage' integrase family
APZ20_19335	COG0795	lipopolysaccharide-transporting ATPase activity
APZ20_19360	COG0525	valine-tRNA ligase activity
APZ20_19370	COG2963	transposase activity
APZ20_19375	COG2801	Transposase and inactivated derivatives
APZ20_19385	COG3039	Transposase
APZ20_19410	COG3039	Transposase
APZ20_19440	COG1183	phosphatidylcholine synthase activity
APZ20_19465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APZ20_19470	COG1127	ABC transporter
APZ20_19475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APZ20_19475	COG3218	ABC-type transport auxiliary lipoprotein component
APZ20_19510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APZ20_19515	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
APZ20_19515	COG0662	Cupin 2, conserved barrel domain protein
APZ20_19540	COG2086	electron transfer activity
APZ20_19565	COG3328	transposase activity
APZ20_19605	COG0626	cystathionine gamma-synthase activity
APZ20_19635	COG0625	glutathione transferase activity
APZ20_19645	COG0513	Belongs to the DEAD box helicase family
APZ20_19655	COG0720	synthase
APZ20_19670	COG1956	GAF domain-containing protein
APZ20_19705	COG0339	signal peptide processing
APZ20_19740	COG3293	Transposase
APZ20_19755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APZ20_19760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ20_19765	COG3842	ATPase activity
APZ20_19850	COG0356	it plays a direct role in the translocation of protons across the membrane
APZ20_19870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APZ20_19880	COG0508	dehydrogenase complex catalyzes the overall conversion of
APZ20_19910	COG2011	ABC-type metal ion transport system permease component
APZ20_19920	COG0697	spore germination
APZ20_19955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APZ20_19960	COG1187	pseudouridine synthase activity
APZ20_19965	COG2813	Specifically methylates the guanine in position
APZ20_19985	COG2205	protein histidine kinase activity
APZ20_19985	COG2202	Pas domain
APZ20_20010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APZ20_20015	COG1522	sequence-specific DNA binding
APZ20_20055	COG0745	RESPONSE REGULATOR receiver
APZ20_20070	COG1404	Belongs to the peptidase S8 family
APZ20_20090	COG0842	Transport permease protein
APZ20_20095	COG1131	(ABC) transporter
APZ20_20100	COG0025	NhaP-type Na H and K H
APZ20_20115	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APZ20_20120	COG1573	uracil-dna glycosylase
APZ20_20130	COG3384	dioxygenase
APZ20_20145	COG0667	Aldo Keto reductase
APZ20_20160	COG3590	peptidase
APZ20_20175	COG0531	amino acid
APZ20_20185	COG3279	Response regulator of the LytR AlgR family
APZ20_20190	COG3279	Response regulator of the LytR AlgR family
APZ20_20195	COG2972	Histidine kinase
APZ20_20235	COG2963	transposase activity
APZ20_20260	COG2204	response regulator
APZ20_20270	COG1271	oxidase subunit
APZ20_20275	COG1294	oxidase, subunit
APZ20_20285	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_20300	COG3039	Transposase
APZ20_20355	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
APZ20_20365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APZ20_20380	COG2963	transposase activity
APZ20_20385	COG2801	Transposase and inactivated derivatives
APZ20_20485	COG2963	transposase activity
APZ20_20490	COG2801	Transposase and inactivated derivatives
APZ20_20630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APZ20_20640	COG1560	Kdo2-lipid A biosynthetic process
APZ20_20685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APZ20_20685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APZ20_20695	COG0242	peptide deformylase activity
APZ20_20700	COG1652	LysM domain
APZ20_20705	COG0758	DNA mediated transformation
APZ20_20725	COG1754	DNA topoisomerase type I activity
APZ20_20725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APZ20_20745	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_20755	COG0616	signal peptide processing
APZ20_20760	COG0534	Mate efflux family protein
APZ20_20780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APZ20_20800	COG1324	tolerance protein
APZ20_20820	COG0511	ligase activity, forming carbon-carbon bonds
APZ20_20830	COG0439	Biotin carboxylase
APZ20_20865	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
APZ20_20900	COG3210	domain, Protein
APZ20_20905	COG2831	hemolysin activation secretion protein
APZ20_20925	COG2453	phosphatase
APZ20_20925	COG0671	phosphoesterase, PA-phosphatase related
APZ20_20930	COG2267	carboxylic ester hydrolase activity
APZ20_20940	COG2267	carboxylic ester hydrolase activity
APZ20_20960	COG0151	Belongs to the GarS family
APZ20_20965	COG1136	(ABC) transporter
APZ20_20965	COG0577	efflux transmembrane transporter activity
APZ20_20975	COG1289	transmembrane transporter activity
APZ20_20990	COG2814	Major facilitator Superfamily
APZ20_21010	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
APZ20_21060	COG2963	transposase activity
APZ20_21100	COG0739	heme binding
APZ20_21115	COG2211	Major facilitator Superfamily
APZ20_21120	COG0708	Exodeoxyribonuclease III
APZ20_21135	COG1192	Involved in chromosome partitioning
APZ20_21140	COG1475	DNA binding
APZ20_21155	COG0463	Glycosyl transferase, family 2
APZ20_21180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APZ20_21205	COG4221	oxidoreductase activity
APZ20_21210	COG2826	transposase and inactivated derivatives, IS30 family
APZ20_21220	COG1414	Transcriptional regulator
APZ20_21230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APZ20_21235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APZ20_21240	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APZ20_21245	COG3485	protocatechuate 3,4-dioxygenase
APZ20_21250	COG3485	protocatechuate 3,4-dioxygenase
APZ20_21270	COG2963	transposase activity
APZ20_21290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APZ20_21295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APZ20_21305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APZ20_21305	COG0045	succinate-CoA ligase (ADP-forming) activity
APZ20_21305	COG1042	CoA-binding domain protein
APZ20_21315	COG2239	Acts as a magnesium transporter
APZ20_21330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APZ20_21335	COG3387	PFAM Glycoside hydrolase 15-related
APZ20_21350	COG3100	YcgL domain-containing protein
APZ20_21355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APZ20_21365	COG0463	Glycosyl transferase, family 2
APZ20_21380	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_21400	COG1040	competence protein
APZ20_21415	COG0628	permease
APZ20_21425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APZ20_21435	COG1595	DNA-templated transcription, initiation
APZ20_21440	COG0753	catalase activity
APZ20_21485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APZ20_21490	COG0180	Tryptophanyl-tRNA synthetase
APZ20_21495	COG3237	CsbD-like
APZ20_21550	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
APZ20_21550	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
APZ20_21575	COG2205	protein histidine kinase activity
APZ20_21580	COG0745	RESPONSE REGULATOR receiver
APZ20_21590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APZ20_21615	COG1566	PFAM secretion protein HlyD family protein
APZ20_21635	COG3039	Transposase
APZ20_21645	COG1199	ATP-dependent helicase activity
APZ20_21675	COG0583	DNA-binding transcription factor activity
APZ20_21710	COG0625	glutathione transferase activity
APZ20_21745	COG4555	ABC transporter
APZ20_21755	COG1476	TRANSCRIPTIONal
APZ20_21780	COG1131	(ABC) transporter
APZ20_21785	COG0842	Transport permease protein
APZ20_21795	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APZ20_21835	COG2963	transposase activity
APZ20_21845	COG3293	Transposase
APZ20_21875	COG1181	Belongs to the D-alanine--D-alanine ligase family
APZ20_21900	COG0564	pseudouridine synthase activity
APZ20_21925	COG0339	signal peptide processing
APZ20_21950	COG3254	rhamnose metabolic process
APZ20_21955	COG0738	Major facilitator superfamily
APZ20_21960	COG1414	Transcriptional regulator
APZ20_21970	COG3293	Transposase
APZ20_21980	COG2205	protein histidine kinase activity
APZ20_21995	COG3459	Glycosyltransferase 36 associated
APZ20_22000	COG2211	Major facilitator Superfamily
APZ20_22005	COG3265	gluconokinase activity
APZ20_22010	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APZ20_22030	COG2963	transposase activity
APZ20_22035	COG2801	Transposase and inactivated derivatives
APZ20_22060	COG3039	Transposase
APZ20_22115	COG1127	ABC transporter
APZ20_22120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APZ20_22125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APZ20_22140	COG2853	Lipoprotein
APZ20_22160	COG3293	Transposase
APZ20_22180	COG2963	transposase activity
APZ20_22215	COG3135	benzoate transporter
APZ20_22220	COG3135	benzoate transporter
APZ20_22240	COG0676	glucose-6-phosphate 1-epimerase activity
APZ20_22260	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APZ20_22265	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APZ20_22270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APZ20_22275	COG1064	alcohol dehydrogenase
APZ20_22320	COG4773	Receptor
APZ20_22340	COG1522	sequence-specific DNA binding
APZ20_22345	COG3186	Phenylalanine-4-hydroxylase
APZ20_22355	COG2755	lipolytic protein G-D-S-L family
APZ20_22370	COG2963	transposase activity
APZ20_22385	COG0656	L-ascorbic acid biosynthetic process
APZ20_22390	COG2130	NADP-dependent
APZ20_22395	COG0667	Aldo Keto reductase
APZ20_22405	COG1187	pseudouridine synthase activity
APZ20_22420	COG1643	Atp-dependent helicase
APZ20_22425	COG4807	Protein conserved in bacteria
APZ20_22430	COG4948	Mandelate Racemase Muconate Lactonizing
APZ20_22435	COG0179	Fumarylacetoacetate (FAA) hydrolase
APZ20_22440	COG1028	Short-chain dehydrogenase reductase Sdr
APZ20_22460	COG3507	Belongs to the glycosyl hydrolase 43 family
APZ20_22500	COG3162	membrane
APZ20_22505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APZ20_22515	COG0708	Exodeoxyribonuclease III
APZ20_22530	COG2091	lysine biosynthetic process via aminoadipic acid
APZ20_22540	COG3540	Alkaline phosphatase
APZ20_22555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APZ20_22560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APZ20_22565	COG2159	amidohydrolase
APZ20_22575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APZ20_22580	COG0583	DNA-binding transcription factor activity
APZ20_22585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APZ20_22600	COG0210	DNA helicase
APZ20_22615	COG0531	amino acid
APZ20_22620	COG1322	Protein conserved in bacteria
APZ20_22630	COG0386	Belongs to the glutathione peroxidase family
APZ20_22645	COG3293	Transposase
APZ20_22680	COG0793	Belongs to the peptidase S41A family
APZ20_22685	COG4942	peptidase
APZ20_22695	COG2234	aminopeptidase activity
APZ20_22745	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APZ20_22750	COG0302	gtp cyclohydrolase
APZ20_22770	COG0477	Major facilitator Superfamily
APZ20_22855	COG1929	Belongs to the glycerate kinase type-1 family
APZ20_22860	COG2271	Major facilitator Superfamily
APZ20_22875	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APZ20_22880	COG0861	Integral membrane protein TerC family
APZ20_22890	COG0584	glycerophosphoryl diester phosphodiesterase
APZ20_22900	COG0671	phosphoesterase, PA-phosphatase related
APZ20_22910	COG0726	polysaccharide deacetylase
APZ20_22925	COG0230	Belongs to the bacterial ribosomal protein bL34 family