locus-tag	class	description
B4599_00025	COG0187	DNA topoisomerase II activity
B4599_00035	COG0501	Belongs to the peptidase M48B family
B4599_00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4599_00095	COG4772	TonB-dependent receptor
B4599_00110	COG3039	Transposase
B4599_00145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4599_00160	COG3039	Transposase
B4599_00170	COG1136	(ABC) transporter
B4599_00220	COG3039	Transposase
B4599_00230	COG0513	Belongs to the DEAD box helicase family
B4599_00275	COG3039	Transposase
B4599_00325	COG1858	cytochrome C peroxidase
B4599_00335	COG0702	epimerase
B4599_00360	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B4599_00375	COG0745	RESPONSE REGULATOR receiver
B4599_00375	COG3706	GGDEF domain
B4599_00385	COG2354	Protein conserved in bacteria
B4599_00395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B4599_00405	COG3293	Transposase
B4599_00415	COG3264	Mechanosensitive ion channel
B4599_00415	COG1511	domain protein
B4599_00495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4599_00600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4599_00610	COG0642	Histidine kinase
B4599_00615	COG1090	epimerase
B4599_00625	COG3039	Transposase
B4599_00650	COG2826	transposase and inactivated derivatives, IS30 family
B4599_00710	COG1136	(ABC) transporter
B4599_00750	COG1272	protein, Hemolysin III
B4599_00755	COG1111	helicase
B4599_00755	COG1205	dead DEAH box helicase
B4599_00815	COG0069	glutamate synthase activity
B4599_00815	COG0070	glutamate synthase
B4599_00815	COG0067	glutamate synthase
B4599_00820	COG0493	'glutamate synthase
B4599_00870	COG1609	Transcriptional regulator
B4599_00905	COG0366	Alpha amylase catalytic
B4599_00910	COG0366	Alpha amylase catalytic
B4599_00960	COG0606	chelatase, subunit chli
B4599_01010	COG1166	arginine decarboxylase activity
B4599_01020	COG3501	Rhs element vgr protein
B4599_01100	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_01125	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B4599_01140	COG0210	DNA helicase
B4599_01160	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
B4599_01200	COG2937	Belongs to the GPAT DAPAT family
B4599_01240	COG3186	Phenylalanine-4-hydroxylase
B4599_01245	COG1522	sequence-specific DNA binding
B4599_01255	COG2826	transposase and inactivated derivatives, IS30 family
B4599_01290	COG1064	alcohol dehydrogenase
B4599_01300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B4599_01310	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B4599_01320	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B4599_01345	COG3039	Transposase
B4599_01350	COG0676	glucose-6-phosphate 1-epimerase activity
B4599_01420	COG3293	Transposase
B4599_01435	COG2853	Lipoprotein
B4599_01450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B4599_01455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B4599_01460	COG1127	ABC transporter
B4599_01490	COG3293	Transposase
B4599_01545	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4599_01555	COG3293	Transposase
B4599_01565	COG3265	gluconokinase activity
B4599_01570	COG2211	Major facilitator Superfamily
B4599_01575	COG3459	Glycosyltransferase 36 associated
B4599_01590	COG2205	protein histidine kinase activity
B4599_01600	COG1414	Transcriptional regulator
B4599_01605	COG0738	Major facilitator superfamily
B4599_01610	COG3254	rhamnose metabolic process
B4599_01635	COG0339	signal peptide processing
B4599_01660	COG0564	pseudouridine synthase activity
B4599_01685	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4599_01695	COG3039	Transposase
B4599_01735	COG3293	Transposase
B4599_01790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4599_01800	COG0842	Transport permease protein
B4599_01805	COG1131	(ABC) transporter
B4599_01810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4599_01830	COG1476	TRANSCRIPTIONal
B4599_01840	COG4555	ABC transporter
B4599_01875	COG0625	glutathione transferase activity
B4599_01920	COG0583	DNA-binding transcription factor activity
B4599_01955	COG1199	ATP-dependent helicase activity
B4599_01975	COG1566	PFAM secretion protein HlyD family protein
B4599_02010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4599_02020	COG0745	RESPONSE REGULATOR receiver
B4599_02025	COG2205	protein histidine kinase activity
B4599_02055	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B4599_02055	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B4599_02115	COG3237	CsbD-like
B4599_02120	COG0180	Tryptophanyl-tRNA synthetase
B4599_02125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4599_02175	COG0753	catalase activity
B4599_02180	COG1595	DNA-templated transcription, initiation
B4599_02190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B4599_02200	COG0628	permease
B4599_02220	COG1040	competence protein
B4599_02245	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_02260	COG0463	Glycosyl transferase, family 2
B4599_02270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4599_02275	COG3100	YcgL domain-containing protein
B4599_02290	COG3387	PFAM Glycoside hydrolase 15-related
B4599_02295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4599_02315	COG2239	Acts as a magnesium transporter
B4599_02325	COG0045	succinate-CoA ligase (ADP-forming) activity
B4599_02325	COG1042	CoA-binding domain protein
B4599_02325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4599_02335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4599_02345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4599_02365	COG2963	transposase activity
B4599_02395	COG3485	protocatechuate 3,4-dioxygenase
B4599_02400	COG3485	protocatechuate 3,4-dioxygenase
B4599_02415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4599_02420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4599_02430	COG1414	Transcriptional regulator
B4599_02445	COG4221	oxidoreductase activity
B4599_02460	COG0018	arginyl-trna synthetase
B4599_02465	COG2003	Belongs to the UPF0758 family
B4599_02470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4599_02495	COG0463	Glycosyl transferase, family 2
B4599_02510	COG1475	DNA binding
B4599_02515	COG1192	Involved in chromosome partitioning
B4599_02530	COG0708	Exodeoxyribonuclease III
B4599_02535	COG2211	Major facilitator Superfamily
B4599_02550	COG0739	heme binding
B4599_02620	COG3293	Transposase
B4599_02645	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B4599_02665	COG2814	Major facilitator Superfamily
B4599_02680	COG1289	transmembrane transporter activity
B4599_02690	COG1136	(ABC) transporter
B4599_02690	COG0577	efflux transmembrane transporter activity
B4599_02695	COG0151	Belongs to the GarS family
B4599_02705	COG0419	ATPase involved in DNA repair
B4599_02725	COG2267	carboxylic ester hydrolase activity
B4599_02735	COG2267	carboxylic ester hydrolase activity
B4599_02740	COG2453	phosphatase
B4599_02740	COG0671	phosphoesterase, PA-phosphatase related
B4599_02755	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B4599_02810	COG0439	Biotin carboxylase
B4599_02820	COG0511	ligase activity, forming carbon-carbon bonds
B4599_02840	COG1324	tolerance protein
B4599_02845	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4599_02865	COG0534	Mate efflux family protein
B4599_02870	COG0616	signal peptide processing
B4599_02880	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_02900	COG1754	DNA topoisomerase type I activity
B4599_02900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4599_02920	COG0758	DNA mediated transformation
B4599_02925	COG1652	LysM domain
B4599_02930	COG0242	peptide deformylase activity
B4599_02940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B4599_02940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4599_02990	COG1560	Kdo2-lipid A biosynthetic process
B4599_03000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4599_03205	COG1063	alcohol dehydrogenase
B4599_03220	COG1294	oxidase, subunit
B4599_03225	COG1271	oxidase subunit
B4599_03240	COG2204	response regulator
B4599_03275	COG2972	Histidine kinase
B4599_03290	COG0531	amino acid
B4599_03310	COG3590	peptidase
B4599_03325	COG0667	Aldo Keto reductase
B4599_03340	COG3384	dioxygenase
B4599_03350	COG1573	uracil-dna glycosylase
B4599_03360	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B4599_03375	COG0025	NhaP-type Na H and K H
B4599_03380	COG1131	(ABC) transporter
B4599_03385	COG0842	Transport permease protein
B4599_03405	COG1404	Belongs to the peptidase S8 family
B4599_03420	COG0745	RESPONSE REGULATOR receiver
B4599_03465	COG1522	sequence-specific DNA binding
B4599_03470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4599_03495	COG2205	protein histidine kinase activity
B4599_03495	COG2202	Pas domain
B4599_03530	COG2813	Specifically methylates the guanine in position
B4599_03535	COG1187	pseudouridine synthase activity
B4599_03540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4599_03575	COG0697	spore germination
B4599_03585	COG2011	ABC-type metal ion transport system permease component
B4599_03615	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4599_03625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4599_03645	COG0356	it plays a direct role in the translocation of protons across the membrane
B4599_03680	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B4599_03735	COG3842	ATPase activity
B4599_03740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4599_03745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B4599_03760	COG3293	Transposase
B4599_03805	COG0339	signal peptide processing
B4599_03845	COG1956	GAF domain-containing protein
B4599_03860	COG0720	synthase
B4599_03870	COG0513	Belongs to the DEAD box helicase family
B4599_03915	COG0626	cystathionine gamma-synthase activity
B4599_03955	COG3328	transposase activity
B4599_03980	COG2086	electron transfer activity
B4599_04005	COG0662	Cupin 2, conserved barrel domain protein
B4599_04005	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B4599_04010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4599_04050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B4599_04050	COG3218	ABC-type transport auxiliary lipoprotein component
B4599_04055	COG1127	ABC transporter
B4599_04060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B4599_04085	COG1183	phosphatidylcholine synthase activity
B4599_04115	COG3039	Transposase
B4599_04170	COG0525	valine-tRNA ligase activity
B4599_04195	COG0795	lipopolysaccharide-transporting ATPase activity
B4599_04210	COG4974	Belongs to the 'phage' integrase family
B4599_04215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B4599_04225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4599_04225	COG0047	phosphoribosylformylglycinamidine synthase activity
B4599_04235	COG5295	Hep Hag repeat protein
B4599_04250	COG1404	Belongs to the peptidase S8 family
B4599_04255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4599_04265	COG1459	type II secretion system
B4599_04270	COG2165	general secretion pathway protein
B4599_04275	COG4970	Tfp pilus assembly protein FimT
B4599_04280	COG2165	general secretion pathway protein
B4599_04285	COG4795	General secretion pathway protein
B4599_04290	COG3156	type II secretion system protein K
B4599_04295	COG3166	PFAM Fimbrial assembly family protein
B4599_04310	COG1450	Type ii and iii secretion system protein
B4599_04325	COG2188	Transcriptional regulator
B4599_04370	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B4599_04375	COG1518	maintenance of DNA repeat elements
B4599_04420	COG1399	metal-binding, possibly nucleic acid-binding protein
B4599_04445	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_04460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4599_04465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B4599_04495	COG3829	transcription factor binding
B4599_04510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B4599_04575	COG2826	transposase and inactivated derivatives, IS30 family
B4599_04585	COG0678	peroxiredoxin activity
B4599_04605	COG0330	HflC and HflK could
B4599_04610	COG0330	HflC and HflK could
B4599_04625	COG0308	aminopeptidase N
B4599_04670	COG1560	Kdo2-lipid A biosynthetic process
B4599_04675	COG1519	Transferase
B4599_04680	COG1538	Outer membrane efflux protein
B4599_04685	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B4599_04765	COG3710	Transcriptional regulator
B4599_04790	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B4599_04835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B4599_04845	COG3781	membrane
B4599_04860	COG0625	glutathione transferase activity
B4599_04870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B4599_04895	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B4599_04990	COG2963	transposase activity
B4599_05025	COG3293	Transposase
B4599_05040	COG3039	Transposase
B4599_05060	COG3293	Transposase
B4599_05065	COG0584	glycerophosphoryl diester phosphodiesterase
B4599_05090	COG0473	3-isopropylmalate dehydrogenase activity
B4599_05140	COG0544	peptidyl-prolyl cis-trans isomerase activity
B4599_05145	COG0740	serine-type endopeptidase activity
B4599_05180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4599_05205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B4599_05215	COG0631	protein serine/threonine phosphatase activity
B4599_05285	COG0582	viral genome integration into host DNA
B4599_05295	COG0859	PFAM glycosyl transferase family 9
B4599_05305	COG1234	tRNA 3'-trailer cleavage
B4599_05310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B4599_05325	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B4599_05330	COG0314	molybdopterin synthase activity
B4599_05360	COG0537	adenosine 5'-monophosphoramidase activity
B4599_05380	COG0714	Associated with various cellular activities
B4599_05400	COG0242	peptide deformylase activity
B4599_05450	COG3039	Transposase
B4599_05475	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B4599_05480	COG0726	polysaccharide deacetylase
B4599_05530	COG2211	Major facilitator Superfamily
B4599_05540	COG1609	Transcriptional regulator
B4599_05545	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_05550	COG2851	Citrate transporter
B4599_05565	COG0642	Histidine kinase
B4599_05570	COG1840	ABC-type Fe3 transport system, periplasmic component
B4599_05575	COG2197	response regulator
B4599_05590	COG0583	DNA-binding transcription factor activity
B4599_05605	COG4191	Histidine kinase
B4599_05625	COG0280	phosphate acetyltransferase
B4599_05625	COG0281	malic enzyme
B4599_05650	COG0352	thiamine-phosphate diphosphorylase activity
B4599_05655	COG1773	rubredoxin
B4599_05660	COG2912	Transglutaminase-like superfamily
B4599_05680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B4599_05705	COG0006	proline dipeptidase activity
B4599_05720	COG3293	Transposase
B4599_05745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4599_05765	COG1561	YicC-like family, N-terminal region
B4599_05790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4599_05800	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B4599_05810	COG0254	rRNA binding
B4599_05830	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B4599_05880	COG0714	Associated with various cellular activities
B4599_05900	COG2304	oxidoreductase activity
B4599_05920	COG1301	dicarboxylic acid transport
B4599_05925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B4599_05930	COG4773	Receptor
B4599_05935	COG0739	heme binding
B4599_05940	COG1376	ErfK ybiS ycfS ynhG family protein
B4599_05965	COG1022	Amp-dependent synthetase and ligase
B4599_05975	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_05990	COG0745	RESPONSE REGULATOR receiver
B4599_05995	COG0642	Histidine kinase
B4599_06015	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B4599_06020	COG4149	molybdate abc transporter
B4599_06025	COG0725	ABC transporter, periplasmic molybdate-binding protein
B4599_06030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4599_06030	COG3453	Protein conserved in bacteria
B4599_06065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4599_06075	COG3293	Transposase
B4599_06090	COG2205	protein histidine kinase activity
B4599_06095	COG0745	RESPONSE REGULATOR receiver
B4599_06145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4599_06150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4599_06195	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4599_06260	COG2201	protein-glutamate methylesterase activity
B4599_06295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B4599_06325	COG1842	Phage shock protein A
B4599_06350	COG0754	glutathionylspermidine amidase activity
B4599_06380	COG0789	Transcriptional regulator
B4599_06435	COG0531	amino acid
B4599_06440	COG2197	response regulator
B4599_06455	COG1113	amino acid transport
B4599_06470	COG1271	oxidase subunit
B4599_06475	COG1294	oxidase, subunit
B4599_06485	COG2239	Acts as a magnesium transporter
B4599_06495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B4599_06500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4599_06520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4599_06535	COG1137	ATPase activity
B4599_06540	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B4599_06550	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B4599_06560	COG0271	Belongs to the BolA IbaG family
B4599_06590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B4599_06615	COG0628	permease
B4599_06625	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B4599_06630	COG3178	'Phosphotransferase
B4599_06645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4599_06650	COG1555	photosystem II stabilization
B4599_06695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4599_06705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B4599_06755	COG0534	Mate efflux family protein
B4599_06790	COG0542	response to heat
B4599_06815	COG4206	TonB-dependent receptor
B4599_06875	COG0019	diaminopimelate decarboxylase activity
B4599_06885	COG2814	Major facilitator Superfamily
B4599_06890	COG4264	IucA IucC family
B4599_06900	COG4772	TonB-dependent receptor
B4599_06915	COG4651	solute:proton antiporter activity
B4599_06915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4599_06950	COG0488	(ABC) transporter
B4599_06975	COG0657	acetylesterase activity
B4599_06975	COG2755	lipolytic protein G-D-S-L family
B4599_06995	COG2207	Transcriptional regulator
B4599_07000	COG0326	Molecular chaperone. Has ATPase activity
B4599_07025	COG3328	transposase activity
B4599_07030	COG0174	glutamine synthetase
B4599_07035	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B4599_07045	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B4599_07085	COG3039	Transposase
B4599_07105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4599_07110	COG0719	Fe-S assembly protein
B4599_07115	COG0396	ATPase activity
B4599_07120	COG0719	Fe-S assembly protein
B4599_07125	COG1959	2 iron, 2 sulfur cluster binding
B4599_07145	COG0693	protein deglycase activity
B4599_07185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B4599_07215	COG0519	Catalyzes the synthesis of GMP from XMP
B4599_07245	COG1764	response to oxidative stress
B4599_07255	COG0384	phenazine biosynthesis protein PhzF
B4599_07265	COG0527	aspartate kinase activity
B4599_07295	COG0142	geranyltranstransferase activity
B4599_07300	COG0629	single-stranded DNA binding
B4599_07305	COG5001	Diguanylate cyclase
B4599_07305	COG4251	negative regulation of phosphorylation
B4599_07305	COG2203	Gaf domain
B4599_07305	COG3706	GGDEF domain
B4599_07345	COG2879	small protein
B4599_07350	COG1966	Carbon starvation protein
B4599_07355	COG1741	Belongs to the pirin family
B4599_07365	COG3501	Rhs element vgr protein
B4599_07385	COG3501	Rhs element vgr protein
B4599_07430	COG1741	Belongs to the pirin family
B4599_07440	COG1515	deoxyribonuclease V activity
B4599_07460	COG3590	peptidase
B4599_07465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4599_07475	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B4599_07480	COG2199	diguanylate cyclase activity
B4599_07480	COG2200	EAL domain
B4599_07480	COG2202	Pas domain
B4599_07485	COG0835	chemotaxis
B4599_07490	COG0840	transmembrane signaling receptor activity
B4599_07495	COG0643	Histidine kinase
B4599_07495	COG2198	Histidine kinase
B4599_07505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B4599_07520	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B4599_07535	COG3039	Transposase
B4599_07545	COG2205	protein histidine kinase activity
B4599_07565	COG3039	Transposase
B4599_07585	COG3039	Transposase
B4599_07625	COG0735	belongs to the Fur family
B4599_07675	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B4599_07680	COG0084	hydrolase, TatD family'
B4599_07695	COG1960	acyl-CoA dehydrogenase activity
B4599_07710	COG0367	asparagine synthase
B4599_07720	COG0305	Participates in initiation and elongation during chromosome replication
B4599_07725	COG0415	Belongs to the DNA photolyase family
B4599_07745	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_07855	COG5002	protein histidine kinase activity
B4599_07855	COG5001	Diguanylate cyclase
B4599_07860	COG1187	pseudouridine synthase activity
B4599_07895	COG0475	glutathione-regulated potassium exporter activity
B4599_07900	COG5002	protein histidine kinase activity
B4599_07900	COG5000	phosphorelay sensor kinase activity
B4599_07905	COG0745	RESPONSE REGULATOR receiver
B4599_07935	COG1132	(ABC) transporter
B4599_07945	COG3293	Transposase
B4599_07965	COG3039	Transposase
B4599_07980	COG3039	Transposase
B4599_08015	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B4599_08025	COG4969	Belongs to the N-Me-Phe pilin family
B4599_08030	COG2194	sulfuric ester hydrolase activity
B4599_08050	COG2184	nucleotidyltransferase activity
B4599_08075	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B4599_08090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4599_08090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B4599_08095	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4599_08100	COG0564	pseudouridine synthase activity
B4599_08125	COG3387	PFAM Glycoside hydrolase 15-related
B4599_08130	COG1877	trehalose-phosphatase activity
B4599_08200	COG1946	Acyl-CoA thioesterase
B4599_08215	COG0824	Thioesterase
B4599_08220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4599_08240	COG0268	Binds directly to 16S ribosomal RNA
B4599_08245	COG0728	peptidoglycan biosynthetic process
B4599_08250	COG0196	riboflavin kinase activity
B4599_08280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B4599_08285	COG1845	cytochrome c oxidase, subunit III
B4599_08290	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B4599_08300	COG3501	Rhs element vgr protein
B4599_08310	COG3209	COG3209 Rhs family protein
B4599_08320	COG3209	COG3209 Rhs family protein
B4599_08460	COG0824	Thioesterase
B4599_08470	COG0848	biopolymer transport protein
B4599_08485	COG2885	chlorophyll binding
B4599_08495	COG0602	queuosine metabolic process
B4599_08500	COG1187	pseudouridine synthase activity
B4599_08545	COG3293	Transposase
B4599_08555	COG3039	Transposase
B4599_08595	COG0514	ATP-dependent DNA helicase (RecQ)
B4599_08605	COG0783	Belongs to the Dps family
B4599_08610	COG1643	Atp-dependent helicase
B4599_08620	COG0837	glucose binding
B4599_08625	COG0837	glucose binding
B4599_08640	COG3293	Transposase
B4599_08680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4599_08695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4599_08705	COG1199	ATP-dependent helicase activity
B4599_08715	COG1397	ADP-ribosylglycohydrolase
B4599_08725	COG0189	ligase activity
B4599_08740	COG0835	chemotaxis
B4599_08745	COG0840	transmembrane signaling receptor activity
B4599_08795	COG1446	asparaginase
B4599_08800	COG3142	Participates in the control of copper homeostasis
B4599_08860	COG3537	Alpha-1,2-mannosidase
B4599_08930	COG1472	Belongs to the glycosyl hydrolase 3 family
B4599_08940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B4599_08950	COG1388	LysM domain
B4599_08950	COG3858	chitin binding
B4599_08965	COG0837	glucose binding
B4599_08970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B4599_08980	COG0494	nUDIX hydrolase
B4599_08990	COG3956	TIGRFAM MazG family protein
B4599_09005	COG0330	HflC and HflK could
B4599_09055	COG1960	acyl-CoA dehydrogenase activity
B4599_09065	COG1309	transcriptional regulator
B4599_09070	COG4771	TonB-dependent receptor
B4599_09080	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B4599_09090	COG0463	Glycosyl transferase, family 2
B4599_09095	COG0517	IMP dehydrogenase activity
B4599_09095	COG0516	GMP reductase activity
B4599_09115	COG1272	protein, Hemolysin III
B4599_09125	COG0739	heme binding
B4599_09130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4599_09135	COG0626	cystathionine gamma-synthase activity
B4599_09145	COG1760	l-serine dehydratase
B4599_09160	COG2353	YceI-like domain
B4599_09170	COG2353	YceI-like domain
B4599_09240	COG1960	acyl-CoA dehydrogenase activity
B4599_09245	COG1024	Enoyl-CoA hydratase
B4599_09265	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4599_09265	COG1024	Enoyl-CoA hydratase
B4599_09280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4599_09340	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B4599_09345	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
B4599_09350	COG3046	protein related to deoxyribodipyrimidine photolyase
B4599_09365	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B4599_09370	COG1278	Cold shock
B4599_09390	COG1201	RNA secondary structure unwinding
B4599_09395	COG1793	dna ligase
B4599_09405	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B4599_09405	COG1793	dna ligase
B4599_09420	COG0745	RESPONSE REGULATOR receiver
B4599_09420	COG3706	GGDEF domain
B4599_09435	COG0183	Belongs to the thiolase family
B4599_09455	COG1451	nucleotide metabolic process
B4599_09470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4599_09505	COG1047	Peptidyl-prolyl cis-trans
B4599_09520	COG2824	Alkylphosphonate utilization operon protein PhnA
B4599_09535	COG1902	pentaerythritol trinitrate reductase activity
B4599_09540	COG2814	Major facilitator Superfamily
B4599_09595	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B4599_09595	COG0392	lysyltransferase activity
B4599_09605	COG0251	oxidation-reduction process
B4599_09610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B4599_09625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B4599_09650	COG1595	DNA-templated transcription, initiation
B4599_09670	COG2878	Part of a membrane complex involved in electron transport
B4599_09700	COG0833	amino acid
B4599_09705	COG2040	homocysteine
B4599_09720	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B4599_09750	COG2895	sulfate adenylyltransferase (ATP) activity
B4599_09750	COG0529	Catalyzes the synthesis of activated sulfate
B4599_09815	COG1131	(ABC) transporter
B4599_09820	COG4771	TonB-dependent receptor
B4599_09880	COG0750	zinc metalloprotease
B4599_09890	COG0575	Belongs to the CDS family
B4599_09955	COG0024	Methionine aminopeptidase
B4599_09975	COG1393	Belongs to the ArsC family
B4599_09990	COG0367	asparagine synthase
B4599_10005	COG4774	siderophore transport
B4599_10040	COG1566	PFAM secretion protein HlyD family protein
B4599_10045	COG2814	Major facilitator Superfamily
B4599_10105	COG1960	acyl-CoA dehydrogenase activity
B4599_10130	COG2914	Belongs to the UPF0125 (RnfH) family
B4599_10140	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4599_10150	COG0497	DNA recombination
B4599_10180	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B4599_10185	COG1605	Chorismate mutase
B4599_10185	COG0287	Prephenate dehydrogenase
B4599_10200	COG0583	DNA-binding transcription factor activity
B4599_10210	COG1132	(ABC) transporter
B4599_10245	COG2850	peptidyl-arginine hydroxylation
B4599_10275	COG1253	flavin adenine dinucleotide binding
B4599_10285	COG3293	Transposase
B4599_10335	COG1131	(ABC) transporter
B4599_10340	COG1725	Transcriptional regulator
B4599_10350	COG0386	Belongs to the glutathione peroxidase family
B4599_10390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4599_10400	COG0646	methionine synthase
B4599_10400	COG1410	methionine synthase
B4599_10405	COG1410	methionine synthase
B4599_10405	COG0646	methionine synthase
B4599_10415	COG1960	acyl-CoA dehydrogenase activity
B4599_10445	COG0557	exoribonuclease II activity
B4599_10465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4599_10475	COG3039	Transposase
B4599_10495	COG3328	transposase activity
B4599_10505	COG1278	Cold shock
B4599_10520	COG3039	Transposase
B4599_10570	COG3039	Transposase
B4599_10620	COG3039	Transposase
B4599_10630	COG0583	DNA-binding transcription factor activity
B4599_10685	COG2201	protein-glutamate methylesterase activity
B4599_10725	COG0531	amino acid
B4599_10730	COG0531	amino acid
B4599_10740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4599_10745	COG0277	FAD linked oxidase domain protein
B4599_10760	COG2801	Transposase and inactivated derivatives
B4599_10810	COG0436	Aminotransferase
B4599_10835	COG1187	pseudouridine synthase activity
B4599_10840	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B4599_10845	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B4599_10850	COG2350	Protein conserved in bacteria
B4599_10880	COG1175	transmembrane transport
B4599_10885	COG0395	ABC-type sugar transport system, permease component
B4599_10910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4599_10915	COG3039	Transposase
B4599_10925	COG2957	Belongs to the agmatine deiminase family
B4599_10935	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B4599_10945	COG0539	negative regulation of cytoplasmic translation
B4599_10960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B4599_10965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4599_10975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4599_11015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4599_11020	COG0583	DNA-binding transcription factor activity
B4599_11035	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_11050	COG0583	DNA-binding transcription factor activity
B4599_11065	COG2201	protein-glutamate methylesterase activity
B4599_11075	COG1914	H( )-stimulated, divalent metal cation uptake system
B4599_11080	COG1321	iron dependent repressor
B4599_11085	COG0590	tRNA wobble adenosine to inosine editing
B4599_11095	COG0668	transmembrane transport
B4599_11135	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_11140	COG1183	phosphatidylcholine synthase activity
B4599_11150	COG3243	poly(R)-hydroxyalkanoic acid synthase
B4599_11165	COG0723	plastoquinol--plastocyanin reductase activity
B4599_11165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4599_11175	COG2183	response to ionizing radiation
B4599_11190	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B4599_11205	COG0671	phosphoesterase, PA-phosphatase related
B4599_11230	COG1794	racemase activity, acting on amino acids and derivatives
B4599_11240	COG0697	spore germination
B4599_11265	COG1012	belongs to the aldehyde dehydrogenase family
B4599_11310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B4599_11325	COG0124	histidyl-tRNA synthetase
B4599_11380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B4599_11380	COG0140	phosphoribosyl-ATP diphosphatase activity
B4599_11420	COG0653	protein targeting
B4599_11435	COG3293	Transposase
B4599_11460	COG3293	Transposase
B4599_11500	COG3293	Transposase
B4599_11520	COG2201	protein-glutamate methylesterase activity
B4599_11530	COG2801	Transposase and inactivated derivatives
B4599_11545	COG3039	Transposase
B4599_11560	COG3328	transposase activity
B4599_11605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4599_11630	COG0811	peptide transport
B4599_11660	COG4591	ABC-type transport system involved in lipoprotein release permease component
B4599_11675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B4599_11690	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B4599_11705	COG0354	folic acid binding
B4599_11720	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4599_11730	COG0363	glucosamine-6-phosphate deaminase activity
B4599_11735	COG0129	dihydroxy-acid dehydratase activity
B4599_11740	COG0800	Aldolase
B4599_11770	COG0784	Response regulator, receiver
B4599_11770	COG2205	protein histidine kinase activity
B4599_11770	COG5002	protein histidine kinase activity
B4599_11785	COG3293	Transposase
B4599_11805	COG3706	GGDEF domain
B4599_11860	COG0386	Belongs to the glutathione peroxidase family
B4599_11945	COG4251	negative regulation of phosphorylation
B4599_11945	COG2203	Gaf domain
B4599_11945	COG3706	GGDEF domain
B4599_11945	COG5001	Diguanylate cyclase
B4599_11965	COG1472	Belongs to the glycosyl hydrolase 3 family
B4599_11995	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B4599_12010	COG0617	tRNA 3'-terminal CCA addition
B4599_12025	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4599_12075	COG4566	intracellular signal transduction
B4599_12100	COG1605	Chorismate mutase
B4599_12100	COG0077	Prephenate dehydratase
B4599_12105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B4599_12110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4599_12160	COG2986	histidine ammonia-lyase
B4599_12170	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B4599_12190	COG2963	transposase activity
B4599_12215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
B4599_12230	COG3115	cell septum assembly
B4599_12255	COG0316	Belongs to the HesB IscA family
B4599_12285	COG0288	reversible hydration of carbon dioxide
B4599_12310	COG2925	Exonuclease
B4599_12320	COG0667	Aldo Keto reductase
B4599_12390	COG0494	nUDIX hydrolase
B4599_12400	COG1024	Enoyl-CoA hydratase
B4599_12410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4599_12425	COG3039	Transposase
B4599_12440	COG3293	Transposase
B4599_12460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B4599_12465	COG0573	inorganic phosphate transmembrane transporter activity
B4599_12480	COG0704	Plays a role in the regulation of phosphate uptake
B4599_12490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B4599_12505	COG3328	transposase activity
B4599_12530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4599_12540	COG1862	Preprotein translocase
B4599_12620	COG3293	Transposase
B4599_12635	COG0405	Gamma-glutamyltransferase
B4599_12640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B4599_12660	COG0742	ribosomal rna small subunit methyltransferase
B4599_12680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4599_12720	COG3039	Transposase
B4599_12750	COG0303	'Molybdopterin
B4599_12760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4599_12770	COG1426	Protein conserved in bacteria
B4599_12785	COG0105	UTP biosynthetic process
B4599_12795	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4599_12795	COG1024	Enoyl-CoA hydratase
B4599_12800	COG0183	Belongs to the thiolase family
B4599_12805	COG0038	chloride channel
B4599_12825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B4599_12850	COG1674	ftsk spoiiie
B4599_12855	COG0492	ferredoxin-NADP+ reductase activity
B4599_12880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B4599_12885	COG0542	response to heat
B4599_12890	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B4599_12900	COG0482	sulfurtransferase activity
B4599_12925	COG5001	Diguanylate cyclase
B4599_12930	COG4585	Histidine kinase
B4599_12940	COG5002	protein histidine kinase activity
B4599_12960	COG0835	chemotaxis
B4599_12960	COG0784	Response regulator, receiver
B4599_12970	COG1558	bacterial-type flagellum-dependent cell motility
B4599_12975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B4599_12980	COG1749	Flagellar hook protein flgE
B4599_12985	COG4787	bacterial-type flagellum-dependent cell motility
B4599_12995	COG4786	Flagellar basal body rod
B4599_13025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4599_13030	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B4599_13060	COG2201	protein-glutamate methylesterase activity
B4599_13065	COG2204	response regulator
B4599_13080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4599_13090	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_13130	COG1677	Flagellar hook-basal body complex protein FliE
B4599_13180	COG3190	flagellar
B4599_13195	COG1987	bacterial-type flagellum assembly
B4599_13200	COG1684	flagellar biosynthetic protein fliR
B4599_13205	COG5001	Diguanylate cyclase
B4599_13205	COG3300	MHYT domain
B4599_13210	COG5001	Diguanylate cyclase
B4599_13210	COG3300	MHYT domain
B4599_13225	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4599_13240	COG0455	bacterial-type flagellum organization
B4599_13260	COG0643	Histidine kinase
B4599_13260	COG2198	Histidine kinase
B4599_13295	COG3039	Transposase
B4599_13305	COG3209	COG3209 Rhs family protein
B4599_13315	COG3039	Transposase
B4599_13325	COG3039	Transposase
B4599_13420	COG3039	Transposase
B4599_13425	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B4599_13430	COG4988	ABC transporter
B4599_13445	COG3039	Transposase
B4599_13515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B4599_13520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4599_13530	COG0137	argininosuccinate synthase activity
B4599_13535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B4599_13550	COG2166	iron-sulfur cluster assembly
B4599_13565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4599_13575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B4599_13590	COG3293	Transposase
B4599_13615	COG3039	Transposase
B4599_13625	COG4677	pectinesterase activity
B4599_13660	COG0402	S-adenosylhomocysteine deaminase activity
B4599_13675	COG1509	lysine 2,3-aminomutase activity
B4599_13680	COG3300	MHYT domain
B4599_13680	COG5001	Diguanylate cyclase
B4599_13695	COG0483	inositol monophosphate 1-phosphatase activity
B4599_13730	COG0513	Belongs to the DEAD box helicase family
B4599_13750	COG0625	glutathione transferase activity
B4599_13765	COG4681	YaeQ
B4599_13770	COG2081	HI0933 family
B4599_13790	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_13820	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4599_13825	COG0802	atpase or kinase
B4599_13830	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B4599_13830	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B4599_13835	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B4599_13845	COG3293	Transposase
B4599_13865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4599_13950	COG3328	transposase activity
B4599_13990	COG2969	positive regulation of protein catabolic process
B4599_13995	COG0625	glutathione transferase activity
B4599_14000	COG2857	Cytochrome c1
B4599_14005	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B4599_14010	COG0723	plastoquinol--plastocyanin reductase activity
B4599_14015	COG0741	lytic transglycosylase activity
B4599_14040	COG1702	phosphate starvation-inducible protein PhoH
B4599_14060	COG4535	Mg2 and Co2 transporter CorC
B4599_14075	COG1012	belongs to the aldehyde dehydrogenase family
B4599_14085	COG1177	transmembrane transport
B4599_14090	COG1176	ABC-type spermidine putrescine transport system, permease component I
B4599_14095	COG3842	ATPase activity
B4599_14130	COG0174	glutamine synthetase
B4599_14135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4599_14140	COG0745	RESPONSE REGULATOR receiver
B4599_14140	COG3706	GGDEF domain
B4599_14145	COG0477	Major facilitator Superfamily
B4599_14155	COG0243	molybdopterin cofactor binding
B4599_14180	COG1121	(ABC) transporter
B4599_14190	COG2733	membrane
B4599_14195	COG0784	Response regulator, receiver
B4599_14195	COG5002	protein histidine kinase activity
B4599_14195	COG2205	protein histidine kinase activity
B4599_14205	COG3039	Transposase
B4599_14215	COG2902	Dehydrogenase
B4599_14225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4599_14230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4599_14250	COG1609	Transcriptional regulator
B4599_14255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B4599_14255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4599_14260	COG1105	Belongs to the carbohydrate kinase PfkB family
B4599_14265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4599_14265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4599_14280	COG3039	Transposase
B4599_14325	COG3501	Rhs element vgr protein
B4599_14340	COG3501	Rhs element vgr protein
B4599_14355	COG3501	Rhs element vgr protein
B4599_14410	COG3039	Transposase
B4599_14445	COG4771	TonB-dependent receptor
B4599_14455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4599_14475	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B4599_14480	COG1360	Flagellar Motor Protein
B4599_14485	COG1192	Involved in chromosome partitioning
B4599_14490	COG0835	chemotaxis
B4599_14500	COG0745	RESPONSE REGULATOR receiver
B4599_14520	COG0840	transmembrane signaling receptor activity
B4599_14535	COG0840	transmembrane signaling receptor activity
B4599_14545	COG0840	transmembrane signaling receptor activity
B4599_14555	COG0840	transmembrane signaling receptor activity
B4599_14565	COG0840	transmembrane signaling receptor activity
B4599_14570	COG0840	transmembrane signaling receptor activity
B4599_14590	COG0835	chemotaxis
B4599_14610	COG0840	transmembrane signaling receptor activity
B4599_14640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4599_14670	COG0318	PFAM AMP-dependent synthetase and ligase
B4599_14675	COG1024	Enoyl-CoA hydratase
B4599_14680	COG2205	protein histidine kinase activity
B4599_14680	COG0784	Response regulator, receiver
B4599_14680	COG2198	Histidine kinase
B4599_14750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4599_14760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B4599_14765	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4599_14775	COG0505	Belongs to the CarA family
B4599_14780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B4599_14795	COG2258	MOSC domain
B4599_14800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4599_14870	COG0477	Major facilitator Superfamily
B4599_14880	COG1070	Carbohydrate kinase
B4599_14890	COG1501	Belongs to the glycosyl hydrolase 31 family
B4599_14905	COG0800	Aldolase
B4599_14920	COG3734	2-keto-3-deoxy-galactonokinase
B4599_14925	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B4599_14935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4599_14950	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B4599_14955	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B4599_14965	COG0351	phosphomethylpyrimidine kinase
B4599_14995	COG0583	DNA-binding transcription factor activity
B4599_15000	COG1741	Belongs to the pirin family
B4599_15020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B4599_15025	COG0305	Participates in initiation and elongation during chromosome replication
B4599_15045	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B4599_15055	COG2137	regulation of response to DNA damage stimulus
B4599_15080	COG1546	Belongs to the CinA family
B4599_15085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4599_15090	COG1923	regulation of RNA biosynthetic process
B4599_15100	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B4599_15105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4599_15115	COG1534	Rna-binding protein
B4599_15130	COG1238	metal cluster binding
B4599_15145	COG2840	Smr protein MutS2
B4599_15215	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B4599_15220	COG0306	phosphate transporter
B4599_15235	COG1253	flavin adenine dinucleotide binding
B4599_15250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4599_15265	COG0477	Major facilitator Superfamily
B4599_15275	COG1132	(ABC) transporter
B4599_15280	COG1136	(ABC) transporter
B4599_15300	COG0438	transferase activity, transferring glycosyl groups
B4599_15310	COG2264	protein methyltransferase activity
B4599_15340	COG2244	polysaccharide biosynthetic process
B4599_15395	COG1595	DNA-templated transcription, initiation
B4599_15410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4599_15430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4599_15485	COG2201	protein-glutamate methylesterase activity
B4599_15505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4599_15510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4599_15560	COG1858	cytochrome C peroxidase
B4599_15595	COG0515	serine threonine protein kinase
B4599_15600	COG0631	protein serine/threonine phosphatase activity
B4599_15635	COG3501	Rhs element vgr protein
B4599_15645	COG3039	Transposase
B4599_15700	COG3039	Transposase
B4599_15715	COG3039	Transposase
B4599_15755	COG2801	Transposase and inactivated derivatives
B4599_15765	COG0316	Belongs to the HesB IscA family
B4599_15765	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B4599_15770	COG2154	pterin-4-alpha-carbinolamine dehydratase
B4599_15780	COG0428	transporter
B4599_15785	COG0428	transporter
B4599_15790	COG3064	Membrane
B4599_15800	COG1530	ribonuclease E activity
B4599_15815	COG3293	Transposase
B4599_15830	COG3039	Transposase
B4599_15850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B4599_15885	COG3039	Transposase
B4599_15895	COG3039	Transposase
B4599_15925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B4599_15925	COG1648	precorrin-2 dehydrogenase activity
B4599_15950	COG0746	molybdenum cofactor guanylyltransferase activity
B4599_16020	COG4206	TonB-dependent receptor
B4599_16055	COG4206	TonB-dependent receptor
B4599_16105	COG0531	amino acid
B4599_16120	COG0006	proline dipeptidase activity
B4599_16130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4599_16145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4599_16150	COG3938	Belongs to the proline racemase family
B4599_16160	COG0552	protein localization to endoplasmic reticulum
B4599_16185	COG0784	Response regulator, receiver
B4599_16185	COG4191	Histidine kinase
B4599_16270	COG3040	lipid binding
B4599_16325	COG0438	transferase activity, transferring glycosyl groups
B4599_16330	COG0438	transferase activity, transferring glycosyl groups
B4599_16375	COG0776	regulation of translation
B4599_16390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B4599_16395	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B4599_16400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B4599_16420	COG2963	transposase activity
B4599_16445	COG0556	nucleotide-excision repair
B4599_16450	COG4969	Belongs to the N-Me-Phe pilin family
B4599_16500	COG1611	Belongs to the LOG family
B4599_16515	COG2095	MarC family integral membrane protein
B4599_16525	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B4599_16530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4599_16565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B4599_16585	COG0195	Participates in both transcription termination and antitermination
B4599_16600	COG1007	ATP synthesis coupled electron transport
B4599_16615	COG0713	ATP synthesis coupled electron transport
B4599_16630	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B4599_16635	COG1034	ATP synthesis coupled electron transport
B4599_16640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B4599_16645	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B4599_16665	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4599_16685	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_16705	COG3293	Transposase
B4599_16790	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4599_16795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4599_16805	COG2890	protein-(glutamine-N5) methyltransferase activity
B4599_16835	COG0433	COG0433 Predicted ATPase
B4599_16855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B4599_16865	COG0412	Dienelactone hydrolase
B4599_16890	COG0489	protein tyrosine kinase activity
B4599_16935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4599_16940	COG2311	Membrane
B4599_16945	COG1047	Peptidyl-prolyl cis-trans
B4599_16950	COG0791	NLP P60 protein
B4599_16955	COG0791	NLP P60 protein
B4599_16975	COG1785	Belongs to the alkaline phosphatase family
B4599_16980	COG0037	tRNA processing
B4599_16990	COG0142	geranyltranstransferase activity
B4599_17010	COG0312	modulator of DNA gyrase
B4599_17015	COG3028	Belongs to the UPF0307 family
B4599_17020	COG0312	modulator of DNA gyrase
B4599_17030	COG3164	Protein of unknown function
B4599_17035	COG1530	ribonuclease E activity
B4599_17045	COG2968	Membrane
B4599_17095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B4599_17125	COG3118	belongs to the thioredoxin family
B4599_17140	COG3293	Transposase
B4599_17200	COG3293	Transposase
B4599_17215	COG3039	Transposase
B4599_17220	COG3039	Transposase
B4599_17240	COG3293	Transposase
B4599_17270	COG2801	Transposase and inactivated derivatives
B4599_17275	COG2963	transposase activity
B4599_17320	COG3273	potassium ion transport
B4599_17320	COG0471	metal ion transport
B4599_17350	COG1970	mechanosensitive ion channel activity
B4599_17365	COG3293	Transposase
B4599_17380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4599_17410	COG0308	aminopeptidase N
B4599_17415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4599_17425	COG2895	sulfate adenylyltransferase (ATP) activity
B4599_17425	COG0529	Catalyzes the synthesis of activated sulfate
B4599_17435	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4599_17465	COG2198	Histidine kinase
B4599_17465	COG0784	Response regulator, receiver
B4599_17465	COG2205	protein histidine kinase activity
B4599_17515	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B4599_17520	COG3588	fructose-bisphosphate aldolase
B4599_17525	COG0469	pyruvate kinase activity
B4599_17555	COG3293	Transposase
B4599_17585	COG0753	catalase activity
B4599_17610	COG3039	Transposase
B4599_17635	COG2207	Transcriptional regulator
B4599_17635	COG1917	Cupin 2, conserved barrel domain protein
B4599_17655	COG1506	peptidase
B4599_17655	COG0823	Involved in the tonB-independent uptake of proteins
B4599_17680	COG3039	Transposase
B4599_17685	COG1297	OPT oligopeptide transporter protein
B4599_17755	COG0406	alpha-ribazole phosphatase activity
B4599_17755	COG0328	RNA-DNA hybrid ribonuclease activity
B4599_17790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B4599_17805	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
B4599_17810	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
B4599_17815	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B4599_17835	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
B4599_17850	COG0732	type I restriction modification DNA specificity domain
B4599_17925	COG3501	Rhs element vgr protein
B4599_17990	COG3501	Rhs element vgr protein
B4599_18015	COG3501	Rhs element vgr protein
B4599_18025	COG3501	Rhs element vgr protein
B4599_18035	COG3039	Transposase
B4599_18040	COG3179	chitinase
B4599_18045	COG3501	Rhs element vgr protein
B4599_18055	COG3501	Rhs element vgr protein
B4599_18105	COG3501	Rhs element vgr protein
B4599_18130	COG3501	Rhs element vgr protein
B4599_18135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4599_18195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4599_18205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4599_18215	COG3501	Rhs element vgr protein
B4599_18265	COG2963	transposase activity
B4599_18295	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B4599_18310	COG2197	response regulator
B4599_18315	COG4585	Histidine kinase
B4599_18335	COG2894	cell division
B4599_18340	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B4599_18350	COG0642	Histidine kinase
B4599_18355	COG0745	RESPONSE REGULATOR receiver
B4599_18360	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B4599_18370	COG2194	sulfuric ester hydrolase activity
B4599_18400	COG3551	Protein conserved in bacteria
B4599_18450	COG3293	Transposase
B4599_18465	COG0203	ribosomal protein L17
B4599_18470	COG0202	RNA polymerase activity
B4599_18485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B4599_18490	COG0201	protein transport
B4599_18500	COG1841	ribosomal large subunit assembly
B4599_18505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B4599_18525	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B4599_18545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B4599_18550	COG0255	Belongs to the universal ribosomal protein uL29 family
B4599_18555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B4599_18580	COG0089	rRNA binding
B4599_18620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B4599_18660	COG0250	Participates in transcription elongation, termination and antitermination
B4599_18665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4599_18695	COG0012	GTP binding
B4599_18710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B4599_18750	COG0521	Mo-molybdopterin cofactor biosynthetic process
B4599_18770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4599_18805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B4599_18815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4599_18845	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B4599_18850	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B4599_18870	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B4599_18885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4599_18885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4599_18930	COG2890	protein-(glutamine-N5) methyltransferase activity
B4599_18940	COG3634	alkyl hydroperoxide reductase activity
B4599_18945	COG0583	DNA-binding transcription factor activity
B4599_18955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B4599_19025	COG4783	chaperone-mediated protein folding
B4599_19040	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B4599_19050	COG0438	transferase activity, transferring glycosyl groups
B4599_19055	COG0671	phosphoesterase, PA-phosphatase related
B4599_19080	COG2833	Protein of unknown function (DUF455)
B4599_19100	COG0285	dihydrofolate synthase activity
B4599_19110	COG0406	alpha-ribazole phosphatase activity
B4599_19145	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B4599_19150	COG4208	sulfate ABC transporter
B4599_19155	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B4599_19160	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B4599_19165	COG0156	8-amino-7-oxononanoate synthase activity
B4599_19200	COG0446	pyridine nucleotide-disulphide oxidoreductase
B4599_19200	COG1902	pentaerythritol trinitrate reductase activity
B4599_19245	COG3706	GGDEF domain
B4599_19245	COG0745	RESPONSE REGULATOR receiver
B4599_19285	COG3293	Transposase
B4599_19335	COG3386	PFAM SMP-30 Gluconolaconase
B4599_19355	COG1024	Enoyl-CoA hydratase
B4599_19365	COG0318	PFAM AMP-dependent synthetase and ligase
B4599_19370	COG0583	DNA-binding transcription factor activity
B4599_19410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4599_19415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4599_19425	COG2096	Adenosyltransferase
B4599_19430	COG0123	including yeast histone deacetylase and acetoin utilization protein
B4599_19445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B4599_19505	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B4599_19520	COG0642	Histidine kinase
B4599_19535	COG4181	ATPase activity
B4599_19545	COG2175	clavaminate synthase activity
B4599_19595	COG0667	Aldo Keto reductase
B4599_19605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4599_19610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4599_19630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4599_19645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B4599_19655	COG3293	Transposase
B4599_19705	COG2226	methyltransferase
B4599_19765	COG3321	synthase
B4599_19765	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_19765	COG0604	alcohol dehydrogenase
B4599_19780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B4599_19800	COG0494	nUDIX hydrolase
B4599_19815	COG4942	peptidase
B4599_19815	COG1388	LysM domain
B4599_19840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B4599_19845	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4599_19870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4599_19885	COG3116	cell division
B4599_19930	COG1988	membrane-bound metal-dependent
B4599_19935	COG0277	FAD linked oxidase domain protein
B4599_19940	COG0745	RESPONSE REGULATOR receiver
B4599_19945	COG2205	protein histidine kinase activity
B4599_19955	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B4599_19960	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B4599_19990	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B4599_20020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4599_20020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4599_20060	COG0488	(ABC) transporter
B4599_20105	COG0745	RESPONSE REGULATOR receiver
B4599_20110	COG2205	protein histidine kinase activity
B4599_20145	COG2205	protein histidine kinase activity
B4599_20200	COG3039	Transposase
B4599_20205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B4599_20210	COG3293	Transposase
B4599_20220	COG3039	Transposase
B4599_20270	COG3039	Transposase
B4599_20280	COG3293	Transposase
B4599_20315	COG0726	polysaccharide deacetylase
B4599_20315	COG1649	PFAM Uncharacterised BCR, COG1649
B4599_20320	COG1215	transferase activity, transferring glycosyl groups
B4599_20330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4599_20335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B4599_20340	COG1609	Transcriptional regulator
B4599_20365	COG3250	beta-galactosidase activity
B4599_20400	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4599_20405	COG4191	Histidine kinase
B4599_20410	COG0784	Response regulator, receiver
B4599_20415	COG4251	negative regulation of phosphorylation
B4599_20420	COG2823	Periplasmic or secreted lipoprotein
B4599_20425	COG0673	inositol 2-dehydrogenase activity
B4599_20430	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B4599_20465	COG1056	cytidyltransferase-related domain
B4599_20465	COG1051	belongs to the nudix hydrolase family
B4599_20510	COG1686	Belongs to the peptidase S11 family
B4599_20520	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B4599_20525	COG2951	lytic endotransglycosylase activity
B4599_20545	COG3501	Rhs element vgr protein
B4599_20555	COG0772	Belongs to the SEDS family
B4599_20570	COG1792	Involved in formation and maintenance of cell shape
B4599_20575	COG1077	Cell shape determining protein MreB Mrl
B4599_20585	COG3039	Transposase
B4599_20635	COG2199	diguanylate cyclase activity
B4599_20640	COG0308	aminopeptidase N
B4599_20670	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B4599_20715	COG1505	serine-type exopeptidase activity
B4599_20750	COG3275	phosphorelay sensor kinase activity
B4599_20775	COG3293	Transposase
B4599_20800	COG0659	secondary active sulfate transmembrane transporter activity
B4599_20805	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B4599_20805	COG5297	Belongs to the glycosyl hydrolase family 6
B4599_20845	COG3293	Transposase
B4599_20885	COG0598	Magnesium transport protein CorA
B4599_20895	COG1113	amino acid transport
B4599_20905	COG5297	Belongs to the glycosyl hydrolase family 6
B4599_20910	COG4305	rare lipoprotein A
B4599_20915	COG0697	spore germination
B4599_20975	COG4221	oxidoreductase activity
B4599_21005	COG0456	acetyltransferase
B4599_21015	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B4599_21060	COG2111	Na H antiporter
B4599_21060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4599_21065	COG1006	Multisubunit Na H antiporter MnhC subunit
B4599_21070	COG0651	ATP synthesis coupled electron transport
B4599_21080	COG2212	antiporter activity
B4599_21085	COG1320	monovalent cation:proton antiporter activity
B4599_21115	COG3104	oligopeptide transport
B4599_21130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4599_21160	COG0183	Belongs to the thiolase family
B4599_21210	COG3039	Transposase
B4599_21240	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B4599_21245	COG3023	N-Acetylmuramoyl-L-alanine amidase
B4599_21255	COG4948	Mandelate Racemase Muconate Lactonizing
B4599_21290	COG3293	Transposase
B4599_21300	COG0531	amino acid
B4599_21315	COG3293	Transposase
B4599_21335	COG4682	membrane
B4599_21340	COG2133	pyrroloquinoline quinone binding
B4599_21380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B4599_21390	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B4599_21395	COG1610	YqeY-like protein
B4599_21405	COG1295	ribonuclease BN
B4599_21410	COG0358	DNA primase activity
B4599_21470	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B4599_21480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B4599_21660	COG3039	Transposase
B4599_21670	COG3328	transposase activity
B4599_21690	COG1473	amidohydrolase
B4599_21695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4599_21700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4599_21715	COG5383	Protein conserved in bacteria
B4599_21755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4599_21775	COG0028	Belongs to the TPP enzyme family
B4599_21780	COG4191	Histidine kinase
B4599_21805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B4599_21820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4599_21825	COG3177	Filamentation induced by cAMP protein fic
B4599_21840	COG0596	Alpha beta hydrolase
B4599_21850	COG0318	PFAM AMP-dependent synthetase and ligase
B4599_21855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4599_21920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B4599_21960	COG3039	Transposase
B4599_22025	COG2201	protein-glutamate methylesterase activity
B4599_22075	COG2353	YceI-like domain
B4599_22110	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B4599_22125	COG3386	PFAM SMP-30 Gluconolaconase
B4599_22170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B4599_22185	COG4771	TonB-dependent receptor
B4599_22200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B4599_22220	COG1252	NADH dehydrogenase
B4599_22230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4599_22240	COG2201	protein-glutamate methylesterase activity
B4599_22245	COG2177	Part of the ABC transporter FtsEX involved in
B4599_22250	COG2884	Cell division ATP-binding protein ftsE
B4599_22260	COG3118	belongs to the thioredoxin family
B4599_22265	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B4599_22275	COG0729	surface antigen
B4599_22280	COG2911	Protein conserved in bacteria
B4599_22315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B4599_22330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4599_22390	COG1733	regulation of RNA biosynthetic process
B4599_22395	COG0702	epimerase
B4599_22430	COG0583	DNA-binding transcription factor activity
B4599_22435	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B4599_22450	COG2205	protein histidine kinase activity
B4599_22455	COG2205	protein histidine kinase activity
B4599_22460	COG0745	RESPONSE REGULATOR receiver
B4599_22490	COG1902	pentaerythritol trinitrate reductase activity
B4599_22495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B4599_22505	COG2814	Major facilitator Superfamily
B4599_22510	COG0583	DNA-binding transcription factor activity
B4599_22530	COG0084	hydrolase, TatD family'
B4599_22565	COG3293	Transposase
B4599_22585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B4599_22655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4599_22660	COG1960	acyl-CoA dehydrogenase activity
B4599_22715	COG0523	cobalamin synthesis protein
B4599_22725	COG0697	spore germination
B4599_22735	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B4599_22750	COG4771	TonB-dependent receptor
B4599_22755	COG0457	Tetratricopeptide repeat
B4599_22770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4599_22790	COG0519	Catalyzes the synthesis of GMP from XMP
B4599_22790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B4599_22800	COG0805	protein transport
B4599_22810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4599_22820	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B4599_22875	COG3661	Belongs to the glycosyl hydrolase 67 family
B4599_22885	COG4948	Mandelate Racemase Muconate Lactonizing
B4599_22895	COG1472	Belongs to the glycosyl hydrolase 3 family
B4599_22900	COG0246	Mannitol dehydrogenase
B4599_22925	COG3693	PFAM glycoside hydrolase, family 10
B4599_22950	COG2211	Major facilitator Superfamily
B4599_22985	COG3293	Transposase
B4599_22995	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B4599_23040	COG1846	Transcriptional regulator
B4599_23045	COG1764	response to oxidative stress
B4599_23140	COG3549	Plasmid maintenance system killer
B4599_23150	COG1074	ATP-dependent DNA helicase activity
B4599_23155	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B4599_23195	COG2032	superoxide dismutase activity
B4599_23200	COG2032	superoxide dismutase activity
B4599_23205	COG2204	response regulator
B4599_23210	COG3852	Histidine kinase
B4599_23215	COG0004	ammonium transporteR
B4599_23220	COG0347	Belongs to the P(II) protein family
B4599_23225	COG0174	glutamine synthetase
B4599_23275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4599_23285	COG2062	phosphohistidine phosphatase, SixA
B4599_23290	COG0489	protein tyrosine kinase activity
B4599_23310	COG1396	sequence-specific DNA binding
B4599_23315	COG3550	peptidyl-serine autophosphorylation
B4599_23320	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B4599_23325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4599_23340	COG0517	IMP dehydrogenase activity
B4599_23340	COG1125	glycine betaine transport
B4599_23355	COG1119	ATPase activity
B4599_23365	COG1752	Esterase of the alpha-beta hydrolase superfamily
B4599_23380	COG3039	Transposase
B4599_23400	COG0656	L-ascorbic acid biosynthetic process
B4599_23405	COG2130	NADP-dependent
B4599_23410	COG0667	Aldo Keto reductase
B4599_23420	COG1187	pseudouridine synthase activity
B4599_23435	COG1643	Atp-dependent helicase
B4599_23440	COG4807	Protein conserved in bacteria
B4599_23445	COG4948	Mandelate Racemase Muconate Lactonizing
B4599_23455	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4599_23460	COG1028	Short-chain dehydrogenase reductase Sdr
B4599_23480	COG3507	Belongs to the glycosyl hydrolase 43 family
B4599_23525	COG3162	membrane
B4599_23530	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4599_23545	COG0708	Exodeoxyribonuclease III
B4599_23560	COG2091	lysine biosynthetic process via aminoadipic acid
B4599_23570	COG3540	Alkaline phosphatase
B4599_23590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B4599_23595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B4599_23600	COG2159	amidohydrolase
B4599_23610	COG2159	amidohydrolase
B4599_23625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B4599_23630	COG0583	DNA-binding transcription factor activity
B4599_23635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4599_23650	COG0210	DNA helicase
B4599_23665	COG0531	amino acid
B4599_23675	COG1322	Protein conserved in bacteria
B4599_23685	COG0386	Belongs to the glutathione peroxidase family
B4599_23735	COG0793	Belongs to the peptidase S41A family
B4599_23740	COG4942	peptidase
B4599_23750	COG2234	aminopeptidase activity
B4599_23795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B4599_23800	COG0302	gtp cyclohydrolase
B4599_23825	COG0477	Major facilitator Superfamily
B4599_23915	COG1929	Belongs to the glycerate kinase type-1 family
B4599_23920	COG2271	Major facilitator Superfamily
B4599_23935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B4599_23945	COG0861	Integral membrane protein TerC family
B4599_23955	COG0584	glycerophosphoryl diester phosphodiesterase
B4599_23965	COG0671	phosphoesterase, PA-phosphatase related
B4599_23975	COG0726	polysaccharide deacetylase
B4599_23990	COG0230	Belongs to the bacterial ribosomal protein bL34 family