locus-tag	class	description
BRN66_00030	COG0187	DNA topoisomerase II activity
BRN66_00040	COG0501	Belongs to the peptidase M48B family
BRN66_00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN66_00100	COG4772	TonB-dependent receptor
BRN66_00115	COG3039	Transposase
BRN66_00125	COG1755	Isoprenylcysteine carboxyl methyltransferase
BRN66_00150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN66_00160	COG3039	Transposase
BRN66_00165	COG1136	(ABC) transporter
BRN66_00215	COG3039	Transposase
BRN66_00225	COG0513	Belongs to the DEAD box helicase family
BRN66_00330	COG1858	cytochrome C peroxidase
BRN66_00340	COG0702	epimerase
BRN66_00365	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BRN66_00380	COG3706	GGDEF domain
BRN66_00380	COG0745	RESPONSE REGULATOR receiver
BRN66_00390	COG2354	Protein conserved in bacteria
BRN66_00400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRN66_00415	COG3264	Mechanosensitive ion channel
BRN66_00415	COG1511	domain protein
BRN66_00495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BRN66_00575	COG3039	Transposase
BRN66_00585	COG3039	Transposase
BRN66_00620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRN66_00630	COG0642	Histidine kinase
BRN66_00640	COG1090	epimerase
BRN66_00650	COG3039	Transposase
BRN66_00675	COG2826	transposase and inactivated derivatives, IS30 family
BRN66_00740	COG1136	(ABC) transporter
BRN66_00785	COG1272	protein, Hemolysin III
BRN66_00790	COG1111	helicase
BRN66_00790	COG1205	dead DEAH box helicase
BRN66_00850	COG0067	glutamate synthase
BRN66_00850	COG0069	glutamate synthase activity
BRN66_00850	COG0070	glutamate synthase
BRN66_00855	COG0493	'glutamate synthase
BRN66_00905	COG1609	Transcriptional regulator
BRN66_00940	COG0366	Alpha amylase catalytic
BRN66_00945	COG0366	Alpha amylase catalytic
BRN66_01000	COG0606	chelatase, subunit chli
BRN66_01050	COG1166	arginine decarboxylase activity
BRN66_01060	COG3501	Rhs element vgr protein
BRN66_01140	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_01165	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BRN66_01180	COG0210	DNA helicase
BRN66_01200	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BRN66_01240	COG2937	Belongs to the GPAT DAPAT family
BRN66_01270	COG2755	lipolytic protein G-D-S-L family
BRN66_01285	COG3186	Phenylalanine-4-hydroxylase
BRN66_01290	COG1522	sequence-specific DNA binding
BRN66_01340	COG1064	alcohol dehydrogenase
BRN66_01350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN66_01360	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN66_01370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN66_01395	COG3039	Transposase
BRN66_01400	COG0676	glucose-6-phosphate 1-epimerase activity
BRN66_01490	COG2853	Lipoprotein
BRN66_01505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRN66_01510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRN66_01515	COG1127	ABC transporter
BRN66_01590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN66_01605	COG3265	gluconokinase activity
BRN66_01610	COG2211	Major facilitator Superfamily
BRN66_01615	COG3459	Glycosyltransferase 36 associated
BRN66_01630	COG2205	protein histidine kinase activity
BRN66_01640	COG1414	Transcriptional regulator
BRN66_01645	COG0738	Major facilitator superfamily
BRN66_01650	COG3254	rhamnose metabolic process
BRN66_01680	COG0339	signal peptide processing
BRN66_01710	COG0564	pseudouridine synthase activity
BRN66_01820	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BRN66_01830	COG0842	Transport permease protein
BRN66_01835	COG1131	(ABC) transporter
BRN66_01840	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRN66_01860	COG1476	TRANSCRIPTIONal
BRN66_01870	COG4555	ABC transporter
BRN66_01910	COG0625	glutathione transferase activity
BRN66_01960	COG0583	DNA-binding transcription factor activity
BRN66_01995	COG1199	ATP-dependent helicase activity
BRN66_02015	COG1566	PFAM secretion protein HlyD family protein
BRN66_02045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRN66_02055	COG0745	RESPONSE REGULATOR receiver
BRN66_02060	COG2205	protein histidine kinase activity
BRN66_02085	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BRN66_02085	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BRN66_02145	COG3237	CsbD-like
BRN66_02150	COG0180	Tryptophanyl-tRNA synthetase
BRN66_02155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRN66_02205	COG0753	catalase activity
BRN66_02210	COG1595	DNA-templated transcription, initiation
BRN66_02220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRN66_02230	COG0628	permease
BRN66_02250	COG1040	competence protein
BRN66_02275	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_02290	COG0463	Glycosyl transferase, family 2
BRN66_02300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRN66_02305	COG3100	YcgL domain-containing protein
BRN66_02320	COG3387	PFAM Glycoside hydrolase 15-related
BRN66_02325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRN66_02345	COG2239	Acts as a magnesium transporter
BRN66_02355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BRN66_02355	COG0045	succinate-CoA ligase (ADP-forming) activity
BRN66_02355	COG1042	CoA-binding domain protein
BRN66_02365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRN66_02375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRN66_02410	COG3485	protocatechuate 3,4-dioxygenase
BRN66_02415	COG3485	protocatechuate 3,4-dioxygenase
BRN66_02430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN66_02435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BRN66_02465	COG4221	oxidoreductase activity
BRN66_02485	COG2003	Belongs to the UPF0758 family
BRN66_02490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BRN66_02515	COG0463	Glycosyl transferase, family 2
BRN66_02530	COG1475	DNA binding
BRN66_02535	COG1192	Involved in chromosome partitioning
BRN66_02550	COG0708	Exodeoxyribonuclease III
BRN66_02555	COG2211	Major facilitator Superfamily
BRN66_02570	COG0739	heme binding
BRN66_02660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BRN66_02685	COG2814	Major facilitator Superfamily
BRN66_02700	COG1289	transmembrane transporter activity
BRN66_02710	COG1136	(ABC) transporter
BRN66_02710	COG0577	efflux transmembrane transporter activity
BRN66_02715	COG0151	Belongs to the GarS family
BRN66_02725	COG0419	ATPase involved in DNA repair
BRN66_02740	COG2267	carboxylic ester hydrolase activity
BRN66_02750	COG2267	carboxylic ester hydrolase activity
BRN66_02755	COG0671	phosphoesterase, PA-phosphatase related
BRN66_02755	COG2453	phosphatase
BRN66_02770	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BRN66_02830	COG0439	Biotin carboxylase
BRN66_02840	COG0511	ligase activity, forming carbon-carbon bonds
BRN66_02865	COG1324	tolerance protein
BRN66_02900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BRN66_02930	COG0534	Mate efflux family protein
BRN66_02935	COG0616	signal peptide processing
BRN66_02945	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_02965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BRN66_02965	COG1754	DNA topoisomerase type I activity
BRN66_02985	COG0758	DNA mediated transformation
BRN66_02990	COG1652	LysM domain
BRN66_02995	COG0242	peptide deformylase activity
BRN66_03005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BRN66_03005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRN66_03055	COG1560	Kdo2-lipid A biosynthetic process
BRN66_03065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRN66_03220	COG1294	oxidase, subunit
BRN66_03225	COG1271	oxidase subunit
BRN66_03240	COG2204	response regulator
BRN66_03270	COG2972	Histidine kinase
BRN66_03285	COG0531	amino acid
BRN66_03305	COG3590	peptidase
BRN66_03320	COG0667	Aldo Keto reductase
BRN66_03335	COG3384	dioxygenase
BRN66_03345	COG1573	uracil-dna glycosylase
BRN66_03355	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BRN66_03370	COG0025	NhaP-type Na H and K H
BRN66_03375	COG1131	(ABC) transporter
BRN66_03380	COG0842	Transport permease protein
BRN66_03395	COG1404	Belongs to the peptidase S8 family
BRN66_03410	COG0745	RESPONSE REGULATOR receiver
BRN66_03455	COG1522	sequence-specific DNA binding
BRN66_03460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN66_03485	COG2205	protein histidine kinase activity
BRN66_03485	COG2202	Pas domain
BRN66_03520	COG2813	Specifically methylates the guanine in position
BRN66_03525	COG1187	pseudouridine synthase activity
BRN66_03530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BRN66_03565	COG0697	spore germination
BRN66_03575	COG2011	ABC-type metal ion transport system permease component
BRN66_03605	COG0508	dehydrogenase complex catalyzes the overall conversion of
BRN66_03615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRN66_03635	COG0356	it plays a direct role in the translocation of protons across the membrane
BRN66_03725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN66_03730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRN66_03785	COG0339	signal peptide processing
BRN66_03825	COG1956	GAF domain-containing protein
BRN66_03840	COG0720	synthase
BRN66_03850	COG0513	Belongs to the DEAD box helicase family
BRN66_03895	COG0626	cystathionine gamma-synthase activity
BRN66_03945	COG3328	transposase activity
BRN66_03970	COG2086	electron transfer activity
BRN66_03995	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BRN66_03995	COG0662	Cupin 2, conserved barrel domain protein
BRN66_04000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRN66_04040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRN66_04040	COG3218	ABC-type transport auxiliary lipoprotein component
BRN66_04045	COG1127	ABC transporter
BRN66_04050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRN66_04075	COG1183	phosphatidylcholine synthase activity
BRN66_04105	COG3039	Transposase
BRN66_04175	COG0525	valine-tRNA ligase activity
BRN66_04200	COG0795	lipopolysaccharide-transporting ATPase activity
BRN66_04215	COG4974	Belongs to the 'phage' integrase family
BRN66_04220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BRN66_04225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BRN66_04225	COG0047	phosphoribosylformylglycinamidine synthase activity
BRN66_04235	COG5295	Hep Hag repeat protein
BRN66_04255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRN66_04265	COG1459	type II secretion system
BRN66_04270	COG2165	general secretion pathway protein
BRN66_04275	COG4970	Tfp pilus assembly protein FimT
BRN66_04280	COG2165	general secretion pathway protein
BRN66_04285	COG4795	General secretion pathway protein
BRN66_04290	COG3156	type II secretion system protein K
BRN66_04295	COG3166	PFAM Fimbrial assembly family protein
BRN66_04310	COG1450	Type ii and iii secretion system protein
BRN66_04325	COG2188	Transcriptional regulator
BRN66_04380	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BRN66_04385	COG1518	maintenance of DNA repeat elements
BRN66_04430	COG1399	metal-binding, possibly nucleic acid-binding protein
BRN66_04455	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_04470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BRN66_04475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BRN66_04510	COG3829	transcription factor binding
BRN66_04545	COG3039	Transposase
BRN66_04605	COG2826	transposase and inactivated derivatives, IS30 family
BRN66_04615	COG0678	peroxiredoxin activity
BRN66_04635	COG0330	HflC and HflK could
BRN66_04640	COG0330	HflC and HflK could
BRN66_04655	COG0308	aminopeptidase N
BRN66_04705	COG1560	Kdo2-lipid A biosynthetic process
BRN66_04710	COG1519	Transferase
BRN66_04715	COG1538	Outer membrane efflux protein
BRN66_04720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRN66_04800	COG3710	Transcriptional regulator
BRN66_04825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BRN66_04845	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BRN66_04875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRN66_04885	COG3781	membrane
BRN66_04905	COG0625	glutathione transferase activity
BRN66_04915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BRN66_04940	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BRN66_05075	COG3039	Transposase
BRN66_05100	COG0584	glycerophosphoryl diester phosphodiesterase
BRN66_05125	COG0473	3-isopropylmalate dehydrogenase activity
BRN66_05185	COG0740	serine-type endopeptidase activity
BRN66_05220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BRN66_05245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRN66_05255	COG0631	protein serine/threonine phosphatase activity
BRN66_05280	COG3501	Rhs element vgr protein
BRN66_05340	COG0582	viral genome integration into host DNA
BRN66_05350	COG0859	PFAM glycosyl transferase family 9
BRN66_05360	COG1234	tRNA 3'-trailer cleavage
BRN66_05365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BRN66_05380	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BRN66_05385	COG0314	molybdopterin synthase activity
BRN66_05415	COG0537	adenosine 5'-monophosphoramidase activity
BRN66_05435	COG0714	Associated with various cellular activities
BRN66_05455	COG0242	peptide deformylase activity
BRN66_05505	COG3039	Transposase
BRN66_05535	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRN66_05540	COG0726	polysaccharide deacetylase
BRN66_05590	COG2211	Major facilitator Superfamily
BRN66_05600	COG1609	Transcriptional regulator
BRN66_05605	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_05610	COG2851	Citrate transporter
BRN66_05630	COG0642	Histidine kinase
BRN66_05635	COG1840	ABC-type Fe3 transport system, periplasmic component
BRN66_05640	COG2197	response regulator
BRN66_05660	COG0583	DNA-binding transcription factor activity
BRN66_05675	COG4191	Histidine kinase
BRN66_05695	COG0280	phosphate acetyltransferase
BRN66_05695	COG0281	malic enzyme
BRN66_05730	COG0352	thiamine-phosphate diphosphorylase activity
BRN66_05735	COG1773	rubredoxin
BRN66_05740	COG2912	Transglutaminase-like superfamily
BRN66_05760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BRN66_05785	COG0006	proline dipeptidase activity
BRN66_05820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BRN66_05840	COG1561	YicC-like family, N-terminal region
BRN66_05865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRN66_05875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BRN66_05885	COG0254	rRNA binding
BRN66_05900	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BRN66_05950	COG0714	Associated with various cellular activities
BRN66_05970	COG2304	oxidoreductase activity
BRN66_05990	COG1301	dicarboxylic acid transport
BRN66_05995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BRN66_06005	COG0739	heme binding
BRN66_06010	COG1376	ErfK ybiS ycfS ynhG family protein
BRN66_06035	COG1022	Amp-dependent synthetase and ligase
BRN66_06045	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_06055	COG0745	RESPONSE REGULATOR receiver
BRN66_06060	COG0642	Histidine kinase
BRN66_06080	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BRN66_06085	COG4149	molybdate abc transporter
BRN66_06090	COG0725	ABC transporter, periplasmic molybdate-binding protein
BRN66_06095	COG3453	Protein conserved in bacteria
BRN66_06095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRN66_06130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BRN66_06150	COG2205	protein histidine kinase activity
BRN66_06155	COG0745	RESPONSE REGULATOR receiver
BRN66_06205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRN66_06210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRN66_06320	COG2201	protein-glutamate methylesterase activity
BRN66_06385	COG1842	Phage shock protein A
BRN66_06410	COG0754	glutathionylspermidine amidase activity
BRN66_06425	COG0789	Transcriptional regulator
BRN66_06480	COG0531	amino acid
BRN66_06485	COG2197	response regulator
BRN66_06500	COG1113	amino acid transport
BRN66_06520	COG1271	oxidase subunit
BRN66_06525	COG1294	oxidase, subunit
BRN66_06535	COG2239	Acts as a magnesium transporter
BRN66_06545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRN66_06550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN66_06570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN66_06585	COG1137	ATPase activity
BRN66_06590	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BRN66_06600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BRN66_06610	COG0271	Belongs to the BolA IbaG family
BRN66_06640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BRN66_06665	COG0628	permease
BRN66_06675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BRN66_06680	COG3178	'Phosphotransferase
BRN66_06695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRN66_06700	COG1555	photosystem II stabilization
BRN66_06745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRN66_06755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BRN66_06805	COG0534	Mate efflux family protein
BRN66_06845	COG0542	response to heat
BRN66_06885	COG4206	TonB-dependent receptor
BRN66_06945	COG0019	diaminopimelate decarboxylase activity
BRN66_06955	COG2814	Major facilitator Superfamily
BRN66_06960	COG4264	IucA IucC family
BRN66_06970	COG4772	TonB-dependent receptor
BRN66_06985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BRN66_06985	COG4651	solute:proton antiporter activity
BRN66_07020	COG0488	(ABC) transporter
BRN66_07045	COG0657	acetylesterase activity
BRN66_07045	COG2755	lipolytic protein G-D-S-L family
BRN66_07065	COG2207	Transcriptional regulator
BRN66_07100	COG3328	transposase activity
BRN66_07105	COG0174	glutamine synthetase
BRN66_07110	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BRN66_07120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BRN66_07175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BRN66_07180	COG0719	Fe-S assembly protein
BRN66_07185	COG0396	ATPase activity
BRN66_07190	COG0719	Fe-S assembly protein
BRN66_07195	COG1959	2 iron, 2 sulfur cluster binding
BRN66_07215	COG0693	protein deglycase activity
BRN66_07260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BRN66_07295	COG0519	Catalyzes the synthesis of GMP from XMP
BRN66_07325	COG1764	response to oxidative stress
BRN66_07335	COG0384	phenazine biosynthesis protein PhzF
BRN66_07345	COG0527	aspartate kinase activity
BRN66_07375	COG0142	geranyltranstransferase activity
BRN66_07380	COG0629	single-stranded DNA binding
BRN66_07385	COG2203	Gaf domain
BRN66_07385	COG5001	Diguanylate cyclase
BRN66_07385	COG4251	negative regulation of phosphorylation
BRN66_07385	COG3706	GGDEF domain
BRN66_07420	COG2879	small protein
BRN66_07425	COG1966	Carbon starvation protein
BRN66_07430	COG1741	Belongs to the pirin family
BRN66_07440	COG3501	Rhs element vgr protein
BRN66_07460	COG3501	Rhs element vgr protein
BRN66_07490	COG3501	Rhs element vgr protein
BRN66_07545	COG1741	Belongs to the pirin family
BRN66_07555	COG1515	deoxyribonuclease V activity
BRN66_07580	COG3590	peptidase
BRN66_07595	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BRN66_07600	COG2200	EAL domain
BRN66_07600	COG2202	Pas domain
BRN66_07600	COG2199	diguanylate cyclase activity
BRN66_07605	COG0835	chemotaxis
BRN66_07610	COG0840	transmembrane signaling receptor activity
BRN66_07615	COG2198	Histidine kinase
BRN66_07615	COG0643	Histidine kinase
BRN66_07625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BRN66_07635	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BRN66_07655	COG2205	protein histidine kinase activity
BRN66_07680	COG3039	Transposase
BRN66_07705	COG3039	Transposase
BRN66_07745	COG0735	belongs to the Fur family
BRN66_07805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BRN66_07810	COG0084	hydrolase, TatD family'
BRN66_07825	COG1960	acyl-CoA dehydrogenase activity
BRN66_07840	COG0367	asparagine synthase
BRN66_07850	COG0305	Participates in initiation and elongation during chromosome replication
BRN66_07855	COG0415	Belongs to the DNA photolyase family
BRN66_07875	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_07920	COG3039	Transposase
BRN66_07980	COG5001	Diguanylate cyclase
BRN66_07980	COG5002	protein histidine kinase activity
BRN66_07985	COG1187	pseudouridine synthase activity
BRN66_08020	COG0475	glutathione-regulated potassium exporter activity
BRN66_08025	COG5002	protein histidine kinase activity
BRN66_08025	COG5000	phosphorelay sensor kinase activity
BRN66_08030	COG0745	RESPONSE REGULATOR receiver
BRN66_08060	COG1132	(ABC) transporter
BRN66_08085	COG3039	Transposase
BRN66_08100	COG3039	Transposase
BRN66_08145	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BRN66_08155	COG4969	Belongs to the N-Me-Phe pilin family
BRN66_08160	COG2194	sulfuric ester hydrolase activity
BRN66_08205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BRN66_08220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRN66_08220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BRN66_08225	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN66_08230	COG0564	pseudouridine synthase activity
BRN66_08255	COG3387	PFAM Glycoside hydrolase 15-related
BRN66_08260	COG1877	trehalose-phosphatase activity
BRN66_08320	COG1595	DNA-templated transcription, initiation
BRN66_08330	COG1946	Acyl-CoA thioesterase
BRN66_08345	COG0824	Thioesterase
BRN66_08350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BRN66_08370	COG0268	Binds directly to 16S ribosomal RNA
BRN66_08375	COG0728	peptidoglycan biosynthetic process
BRN66_08380	COG0196	riboflavin kinase activity
BRN66_08410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BRN66_08415	COG1845	cytochrome c oxidase, subunit III
BRN66_08420	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BRN66_08430	COG3501	Rhs element vgr protein
BRN66_08440	COG3209	COG3209 Rhs family protein
BRN66_08440	COG3209	COG3209 Rhs family protein
BRN66_08575	COG0824	Thioesterase
BRN66_08585	COG0848	biopolymer transport protein
BRN66_08600	COG2885	chlorophyll binding
BRN66_08610	COG0602	queuosine metabolic process
BRN66_08620	COG1187	pseudouridine synthase activity
BRN66_08705	COG0514	ATP-dependent DNA helicase (RecQ)
BRN66_08715	COG0783	Belongs to the Dps family
BRN66_08720	COG1643	Atp-dependent helicase
BRN66_08775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRN66_08790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BRN66_08800	COG1199	ATP-dependent helicase activity
BRN66_08810	COG1397	ADP-ribosylglycohydrolase
BRN66_08820	COG0189	ligase activity
BRN66_08835	COG0835	chemotaxis
BRN66_08840	COG0840	transmembrane signaling receptor activity
BRN66_08890	COG1446	asparaginase
BRN66_08895	COG3142	Participates in the control of copper homeostasis
BRN66_08950	COG3537	Alpha-1,2-mannosidase
BRN66_09020	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN66_09040	COG1388	LysM domain
BRN66_09040	COG3858	chitin binding
BRN66_09055	COG0837	glucose binding
BRN66_09060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BRN66_09070	COG0494	nUDIX hydrolase
BRN66_09080	COG3956	TIGRFAM MazG family protein
BRN66_09095	COG0330	HflC and HflK could
BRN66_09145	COG1960	acyl-CoA dehydrogenase activity
BRN66_09155	COG1309	transcriptional regulator
BRN66_09160	COG4771	TonB-dependent receptor
BRN66_09170	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BRN66_09180	COG0463	Glycosyl transferase, family 2
BRN66_09200	COG1272	protein, Hemolysin III
BRN66_09210	COG0739	heme binding
BRN66_09215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN66_09220	COG0626	cystathionine gamma-synthase activity
BRN66_09230	COG1760	l-serine dehydratase
BRN66_09245	COG2353	YceI-like domain
BRN66_09255	COG2353	YceI-like domain
BRN66_09305	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BRN66_09325	COG1960	acyl-CoA dehydrogenase activity
BRN66_09330	COG1024	Enoyl-CoA hydratase
BRN66_09350	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRN66_09350	COG1024	Enoyl-CoA hydratase
BRN66_09365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRN66_09425	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BRN66_09430	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BRN66_09435	COG3046	protein related to deoxyribodipyrimidine photolyase
BRN66_09450	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BRN66_09455	COG1278	Cold shock
BRN66_09475	COG1201	RNA secondary structure unwinding
BRN66_09480	COG1793	dna ligase
BRN66_09490	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BRN66_09490	COG1793	dna ligase
BRN66_09505	COG0745	RESPONSE REGULATOR receiver
BRN66_09505	COG3706	GGDEF domain
BRN66_09520	COG0183	Belongs to the thiolase family
BRN66_09545	COG1451	nucleotide metabolic process
BRN66_09560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BRN66_09605	COG1047	Peptidyl-prolyl cis-trans
BRN66_09620	COG2824	Alkylphosphonate utilization operon protein PhnA
BRN66_09635	COG1902	pentaerythritol trinitrate reductase activity
BRN66_09640	COG2814	Major facilitator Superfamily
BRN66_09695	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BRN66_09695	COG0392	lysyltransferase activity
BRN66_09705	COG0251	oxidation-reduction process
BRN66_09710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRN66_09725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRN66_09750	COG1595	DNA-templated transcription, initiation
BRN66_09770	COG2878	Part of a membrane complex involved in electron transport
BRN66_09800	COG0833	amino acid
BRN66_09805	COG2040	homocysteine
BRN66_09820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRN66_09855	COG2895	sulfate adenylyltransferase (ATP) activity
BRN66_09855	COG0529	Catalyzes the synthesis of activated sulfate
BRN66_09925	COG1131	(ABC) transporter
BRN66_09930	COG4771	TonB-dependent receptor
BRN66_09985	COG0750	zinc metalloprotease
BRN66_09995	COG0575	Belongs to the CDS family
BRN66_10060	COG0024	Methionine aminopeptidase
BRN66_10080	COG1393	Belongs to the ArsC family
BRN66_10095	COG0367	asparagine synthase
BRN66_10110	COG4774	siderophore transport
BRN66_10150	COG1566	PFAM secretion protein HlyD family protein
BRN66_10155	COG2814	Major facilitator Superfamily
BRN66_10210	COG1960	acyl-CoA dehydrogenase activity
BRN66_10235	COG2914	Belongs to the UPF0125 (RnfH) family
BRN66_10245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN66_10255	COG0497	DNA recombination
BRN66_10285	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BRN66_10290	COG0287	Prephenate dehydrogenase
BRN66_10290	COG1605	Chorismate mutase
BRN66_10310	COG0583	DNA-binding transcription factor activity
BRN66_10325	COG1132	(ABC) transporter
BRN66_10360	COG2850	peptidyl-arginine hydroxylation
BRN66_10440	COG1131	(ABC) transporter
BRN66_10445	COG1725	Transcriptional regulator
BRN66_10455	COG0386	Belongs to the glutathione peroxidase family
BRN66_10495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN66_10505	COG0646	methionine synthase
BRN66_10505	COG1410	methionine synthase
BRN66_10510	COG1410	methionine synthase
BRN66_10510	COG0646	methionine synthase
BRN66_10520	COG1960	acyl-CoA dehydrogenase activity
BRN66_10550	COG0557	exoribonuclease II activity
BRN66_10570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRN66_10585	COG3039	Transposase
BRN66_10610	COG3328	transposase activity
BRN66_10620	COG1278	Cold shock
BRN66_10635	COG3039	Transposase
BRN66_10640	COG3039	Transposase
BRN66_10690	COG3039	Transposase
BRN66_10700	COG0583	DNA-binding transcription factor activity
BRN66_10760	COG2201	protein-glutamate methylesterase activity
BRN66_10805	COG0531	amino acid
BRN66_10810	COG0531	amino acid
BRN66_10820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BRN66_10825	COG0277	FAD linked oxidase domain protein
BRN66_10890	COG0436	Aminotransferase
BRN66_10915	COG1187	pseudouridine synthase activity
BRN66_10920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BRN66_10925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BRN66_10930	COG2350	Protein conserved in bacteria
BRN66_10960	COG1175	transmembrane transport
BRN66_10965	COG0395	ABC-type sugar transport system, permease component
BRN66_10990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRN66_11000	COG2957	Belongs to the agmatine deiminase family
BRN66_11010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BRN66_11020	COG0539	negative regulation of cytoplasmic translation
BRN66_11035	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BRN66_11040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRN66_11050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BRN66_11090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRN66_11095	COG0583	DNA-binding transcription factor activity
BRN66_11125	COG0583	DNA-binding transcription factor activity
BRN66_11140	COG2201	protein-glutamate methylesterase activity
BRN66_11150	COG1914	H( )-stimulated, divalent metal cation uptake system
BRN66_11155	COG1321	iron dependent repressor
BRN66_11160	COG0590	tRNA wobble adenosine to inosine editing
BRN66_11170	COG0668	transmembrane transport
BRN66_11210	COG3039	Transposase
BRN66_11230	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_11235	COG1183	phosphatidylcholine synthase activity
BRN66_11245	COG3243	poly(R)-hydroxyalkanoic acid synthase
BRN66_11260	COG0723	plastoquinol--plastocyanin reductase activity
BRN66_11260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN66_11270	COG2183	response to ionizing radiation
BRN66_11285	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BRN66_11300	COG0671	phosphoesterase, PA-phosphatase related
BRN66_11325	COG1794	racemase activity, acting on amino acids and derivatives
BRN66_11335	COG0697	spore germination
BRN66_11360	COG1012	belongs to the aldehyde dehydrogenase family
BRN66_11395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BRN66_11410	COG0124	histidyl-tRNA synthetase
BRN66_11455	COG2801	Transposase and inactivated derivatives
BRN66_11470	COG3039	Transposase
BRN66_11495	COG3328	transposase activity
BRN66_11540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BRN66_11565	COG0811	peptide transport
BRN66_11595	COG4591	ABC-type transport system involved in lipoprotein release permease component
BRN66_11610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BRN66_11625	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BRN66_11640	COG0354	folic acid binding
BRN66_11655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRN66_11665	COG0363	glucosamine-6-phosphate deaminase activity
BRN66_11670	COG0129	dihydroxy-acid dehydratase activity
BRN66_11675	COG0800	Aldolase
BRN66_11705	COG5002	protein histidine kinase activity
BRN66_11705	COG2205	protein histidine kinase activity
BRN66_11705	COG0784	Response regulator, receiver
BRN66_11735	COG3706	GGDEF domain
BRN66_11790	COG0386	Belongs to the glutathione peroxidase family
BRN66_11880	COG4251	negative regulation of phosphorylation
BRN66_11880	COG2203	Gaf domain
BRN66_11880	COG5001	Diguanylate cyclase
BRN66_11880	COG3706	GGDEF domain
BRN66_11900	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN66_11950	COG0617	tRNA 3'-terminal CCA addition
BRN66_11965	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRN66_12015	COG4566	intracellular signal transduction
BRN66_12060	COG0077	Prephenate dehydratase
BRN66_12060	COG1605	Chorismate mutase
BRN66_12070	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BRN66_12120	COG2986	histidine ammonia-lyase
BRN66_12130	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BRN66_12170	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BRN66_12185	COG3115	cell septum assembly
BRN66_12210	COG0316	Belongs to the HesB IscA family
BRN66_12245	COG0288	reversible hydration of carbon dioxide
BRN66_12270	COG2925	Exonuclease
BRN66_12280	COG0667	Aldo Keto reductase
BRN66_12350	COG0494	nUDIX hydrolase
BRN66_12360	COG1024	Enoyl-CoA hydratase
BRN66_12370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BRN66_12385	COG3039	Transposase
BRN66_12425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BRN66_12430	COG0573	inorganic phosphate transmembrane transporter activity
BRN66_12445	COG0704	Plays a role in the regulation of phosphate uptake
BRN66_12455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRN66_12470	COG3328	transposase activity
BRN66_12505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRN66_12515	COG1862	Preprotein translocase
BRN66_12605	COG0405	Gamma-glutamyltransferase
BRN66_12610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRN66_12630	COG0742	ribosomal rna small subunit methyltransferase
BRN66_12650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BRN66_12680	COG3039	Transposase
BRN66_12690	COG3039	Transposase
BRN66_12720	COG0303	'Molybdopterin
BRN66_12730	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRN66_12740	COG1426	Protein conserved in bacteria
BRN66_12755	COG0105	UTP biosynthetic process
BRN66_12765	COG1024	Enoyl-CoA hydratase
BRN66_12765	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRN66_12770	COG0183	Belongs to the thiolase family
BRN66_12775	COG0038	chloride channel
BRN66_12795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BRN66_12820	COG1674	ftsk spoiiie
BRN66_12825	COG0492	ferredoxin-NADP+ reductase activity
BRN66_12845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BRN66_12850	COG0542	response to heat
BRN66_12855	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BRN66_12865	COG0482	sulfurtransferase activity
BRN66_12890	COG5001	Diguanylate cyclase
BRN66_12895	COG4585	Histidine kinase
BRN66_12905	COG5002	protein histidine kinase activity
BRN66_12925	COG0835	chemotaxis
BRN66_12925	COG0784	Response regulator, receiver
BRN66_12935	COG1558	bacterial-type flagellum-dependent cell motility
BRN66_12940	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BRN66_12945	COG1749	Flagellar hook protein flgE
BRN66_12950	COG4787	bacterial-type flagellum-dependent cell motility
BRN66_12960	COG4786	Flagellar basal body rod
BRN66_12990	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BRN66_12995	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BRN66_13025	COG2201	protein-glutamate methylesterase activity
BRN66_13030	COG2204	response regulator
BRN66_13045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRN66_13055	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_13090	COG1677	Flagellar hook-basal body complex protein FliE
BRN66_13140	COG3190	flagellar
BRN66_13155	COG1987	bacterial-type flagellum assembly
BRN66_13160	COG1684	flagellar biosynthetic protein fliR
BRN66_13165	COG5001	Diguanylate cyclase
BRN66_13165	COG3300	MHYT domain
BRN66_13170	COG5001	Diguanylate cyclase
BRN66_13170	COG3300	MHYT domain
BRN66_13185	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BRN66_13195	COG0455	bacterial-type flagellum organization
BRN66_13215	COG2198	Histidine kinase
BRN66_13215	COG0643	Histidine kinase
BRN66_13255	COG3039	Transposase
BRN66_13350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BRN66_13355	COG4988	ABC transporter
BRN66_13380	COG1271	oxidase subunit
BRN66_13450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BRN66_13455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRN66_13465	COG0137	argininosuccinate synthase activity
BRN66_13470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BRN66_13485	COG2166	iron-sulfur cluster assembly
BRN66_13500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BRN66_13510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BRN66_13550	COG3039	Transposase
BRN66_13565	COG4677	pectinesterase activity
BRN66_13600	COG0402	S-adenosylhomocysteine deaminase activity
BRN66_13615	COG1509	lysine 2,3-aminomutase activity
BRN66_13620	COG3300	MHYT domain
BRN66_13620	COG5001	Diguanylate cyclase
BRN66_13635	COG0483	inositol monophosphate 1-phosphatase activity
BRN66_13670	COG0513	Belongs to the DEAD box helicase family
BRN66_13690	COG0625	glutathione transferase activity
BRN66_13705	COG4681	YaeQ
BRN66_13710	COG2081	HI0933 family
BRN66_13730	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_13760	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRN66_13765	COG0802	atpase or kinase
BRN66_13770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BRN66_13770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BRN66_13775	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRN66_13800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN66_13885	COG3328	transposase activity
BRN66_13930	COG2969	positive regulation of protein catabolic process
BRN66_13935	COG0625	glutathione transferase activity
BRN66_13940	COG2857	Cytochrome c1
BRN66_13945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BRN66_13950	COG0723	plastoquinol--plastocyanin reductase activity
BRN66_13960	COG0741	lytic transglycosylase activity
BRN66_13985	COG1702	phosphate starvation-inducible protein PhoH
BRN66_14005	COG4535	Mg2 and Co2 transporter CorC
BRN66_14020	COG1012	belongs to the aldehyde dehydrogenase family
BRN66_14030	COG1177	transmembrane transport
BRN66_14035	COG1176	ABC-type spermidine putrescine transport system, permease component I
BRN66_14040	COG3842	ATPase activity
BRN66_14080	COG0174	glutamine synthetase
BRN66_14085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN66_14090	COG3706	GGDEF domain
BRN66_14090	COG0745	RESPONSE REGULATOR receiver
BRN66_14095	COG0477	Major facilitator Superfamily
BRN66_14105	COG0243	molybdopterin cofactor binding
BRN66_14140	COG1121	(ABC) transporter
BRN66_14150	COG2733	membrane
BRN66_14155	COG0784	Response regulator, receiver
BRN66_14155	COG2205	protein histidine kinase activity
BRN66_14155	COG5002	protein histidine kinase activity
BRN66_14165	COG3039	Transposase
BRN66_14175	COG2902	Dehydrogenase
BRN66_14185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN66_14190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN66_14210	COG1609	Transcriptional regulator
BRN66_14215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRN66_14215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRN66_14220	COG1105	Belongs to the carbohydrate kinase PfkB family
BRN66_14225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRN66_14225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BRN66_14245	COG3039	Transposase
BRN66_14290	COG3501	Rhs element vgr protein
BRN66_14310	COG3501	Rhs element vgr protein
BRN66_14370	COG3039	Transposase
BRN66_14380	COG3039	Transposase
BRN66_14405	COG4771	TonB-dependent receptor
BRN66_14415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRN66_14435	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BRN66_14440	COG1360	Flagellar Motor Protein
BRN66_14445	COG1192	Involved in chromosome partitioning
BRN66_14450	COG0835	chemotaxis
BRN66_14460	COG0745	RESPONSE REGULATOR receiver
BRN66_14485	COG0840	transmembrane signaling receptor activity
BRN66_14500	COG0840	transmembrane signaling receptor activity
BRN66_14510	COG0840	transmembrane signaling receptor activity
BRN66_14520	COG0840	transmembrane signaling receptor activity
BRN66_14525	COG0840	transmembrane signaling receptor activity
BRN66_14530	COG0840	transmembrane signaling receptor activity
BRN66_14535	COG0840	transmembrane signaling receptor activity
BRN66_14555	COG0835	chemotaxis
BRN66_14580	COG0840	transmembrane signaling receptor activity
BRN66_14615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRN66_14645	COG0318	PFAM AMP-dependent synthetase and ligase
BRN66_14650	COG1024	Enoyl-CoA hydratase
BRN66_14655	COG0784	Response regulator, receiver
BRN66_14655	COG2198	Histidine kinase
BRN66_14655	COG2205	protein histidine kinase activity
BRN66_14725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BRN66_14735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN66_14740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BRN66_14750	COG0505	Belongs to the CarA family
BRN66_14755	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BRN66_14765	COG2258	MOSC domain
BRN66_14770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BRN66_14840	COG0477	Major facilitator Superfamily
BRN66_14850	COG1070	Carbohydrate kinase
BRN66_14860	COG1501	Belongs to the glycosyl hydrolase 31 family
BRN66_14875	COG0800	Aldolase
BRN66_14890	COG3734	2-keto-3-deoxy-galactonokinase
BRN66_14895	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BRN66_14905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRN66_14920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRN66_14925	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BRN66_14935	COG0351	phosphomethylpyrimidine kinase
BRN66_14965	COG0583	DNA-binding transcription factor activity
BRN66_14970	COG1741	Belongs to the pirin family
BRN66_14990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BRN66_14995	COG0305	Participates in initiation and elongation during chromosome replication
BRN66_15020	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BRN66_15030	COG2137	regulation of response to DNA damage stimulus
BRN66_15055	COG1546	Belongs to the CinA family
BRN66_15060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BRN66_15065	COG1923	regulation of RNA biosynthetic process
BRN66_15075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BRN66_15080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BRN66_15090	COG1534	Rna-binding protein
BRN66_15105	COG1238	metal cluster binding
BRN66_15120	COG2840	Smr protein MutS2
BRN66_15195	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BRN66_15200	COG0306	phosphate transporter
BRN66_15215	COG1253	flavin adenine dinucleotide binding
BRN66_15230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BRN66_15250	COG0477	Major facilitator Superfamily
BRN66_15260	COG1132	(ABC) transporter
BRN66_15265	COG1136	(ABC) transporter
BRN66_15285	COG0438	transferase activity, transferring glycosyl groups
BRN66_15295	COG2264	protein methyltransferase activity
BRN66_15325	COG2244	polysaccharide biosynthetic process
BRN66_15375	COG1595	DNA-templated transcription, initiation
BRN66_15390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRN66_15410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRN66_15465	COG2201	protein-glutamate methylesterase activity
BRN66_15485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN66_15490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN66_15545	COG1858	cytochrome C peroxidase
BRN66_15580	COG0515	serine threonine protein kinase
BRN66_15585	COG0631	protein serine/threonine phosphatase activity
BRN66_15620	COG3501	Rhs element vgr protein
BRN66_15700	COG3039	Transposase
BRN66_15720	COG3039	Transposase
BRN66_15765	COG0316	Belongs to the HesB IscA family
BRN66_15765	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BRN66_15770	COG2154	pterin-4-alpha-carbinolamine dehydratase
BRN66_15780	COG0428	transporter
BRN66_15785	COG0428	transporter
BRN66_15790	COG3064	Membrane
BRN66_15800	COG1530	ribonuclease E activity
BRN66_15825	COG3039	Transposase
BRN66_15845	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BRN66_15885	COG3039	Transposase
BRN66_15890	COG3039	Transposase
BRN66_15920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BRN66_15920	COG1648	precorrin-2 dehydrogenase activity
BRN66_15945	COG0746	molybdenum cofactor guanylyltransferase activity
BRN66_16020	COG3328	transposase activity
BRN66_16025	COG4206	TonB-dependent receptor
BRN66_16060	COG4206	TonB-dependent receptor
BRN66_16110	COG0531	amino acid
BRN66_16125	COG0006	proline dipeptidase activity
BRN66_16135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRN66_16150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN66_16155	COG3938	Belongs to the proline racemase family
BRN66_16165	COG0552	protein localization to endoplasmic reticulum
BRN66_16190	COG0784	Response regulator, receiver
BRN66_16190	COG4191	Histidine kinase
BRN66_16280	COG3040	lipid binding
BRN66_16330	COG0438	transferase activity, transferring glycosyl groups
BRN66_16335	COG0438	transferase activity, transferring glycosyl groups
BRN66_16380	COG0776	regulation of translation
BRN66_16395	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BRN66_16400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BRN66_16405	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BRN66_16445	COG4969	Belongs to the N-Me-Phe pilin family
BRN66_16485	COG1611	Belongs to the LOG family
BRN66_16500	COG2095	MarC family integral membrane protein
BRN66_16510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BRN66_16515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRN66_16550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BRN66_16570	COG0195	Participates in both transcription termination and antitermination
BRN66_16585	COG1007	ATP synthesis coupled electron transport
BRN66_16600	COG0713	ATP synthesis coupled electron transport
BRN66_16620	COG1034	ATP synthesis coupled electron transport
BRN66_16625	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BRN66_16630	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BRN66_16650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRN66_16670	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_16770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BRN66_16775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BRN66_16785	COG2890	protein-(glutamine-N5) methyltransferase activity
BRN66_16840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN66_16850	COG0412	Dienelactone hydrolase
BRN66_16880	COG0489	protein tyrosine kinase activity
BRN66_16925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRN66_16930	COG2311	Membrane
BRN66_16935	COG1047	Peptidyl-prolyl cis-trans
BRN66_16940	COG0791	NLP P60 protein
BRN66_16945	COG0791	NLP P60 protein
BRN66_16960	COG1301	dicarboxylic acid transport
BRN66_16965	COG1785	Belongs to the alkaline phosphatase family
BRN66_16970	COG0037	tRNA processing
BRN66_16980	COG0142	geranyltranstransferase activity
BRN66_17005	COG0312	modulator of DNA gyrase
BRN66_17010	COG3028	Belongs to the UPF0307 family
BRN66_17015	COG0312	modulator of DNA gyrase
BRN66_17025	COG3164	Protein of unknown function
BRN66_17030	COG1530	ribonuclease E activity
BRN66_17040	COG2968	Membrane
BRN66_17090	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BRN66_17120	COG3118	belongs to the thioredoxin family
BRN66_17200	COG3039	Transposase
BRN66_17205	COG3039	Transposase
BRN66_17315	COG3273	potassium ion transport
BRN66_17315	COG0471	metal ion transport
BRN66_17345	COG1970	mechanosensitive ion channel activity
BRN66_17370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRN66_17400	COG0308	aminopeptidase N
BRN66_17405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN66_17420	COG2895	sulfate adenylyltransferase (ATP) activity
BRN66_17420	COG0529	Catalyzes the synthesis of activated sulfate
BRN66_17430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BRN66_17460	COG2205	protein histidine kinase activity
BRN66_17460	COG2198	Histidine kinase
BRN66_17460	COG0784	Response regulator, receiver
BRN66_17505	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BRN66_17510	COG3588	fructose-bisphosphate aldolase
BRN66_17515	COG0469	pyruvate kinase activity
BRN66_17560	COG0753	catalase activity
BRN66_17585	COG3039	Transposase
BRN66_17605	COG2207	Transcriptional regulator
BRN66_17605	COG1917	Cupin 2, conserved barrel domain protein
BRN66_17635	COG0823	Involved in the tonB-independent uptake of proteins
BRN66_17635	COG1506	peptidase
BRN66_17660	COG3039	Transposase
BRN66_17665	COG1297	OPT oligopeptide transporter protein
BRN66_17735	COG0328	RNA-DNA hybrid ribonuclease activity
BRN66_17735	COG0406	alpha-ribazole phosphatase activity
BRN66_17770	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BRN66_17775	COG3039	Transposase
BRN66_17790	COG0732	type I restriction modification DNA specificity domain
BRN66_17795	COG3039	Transposase
BRN66_17805	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BRN66_17810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BRN66_17830	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BRN66_17950	COG3501	Rhs element vgr protein
BRN66_18015	COG3501	Rhs element vgr protein
BRN66_18025	COG3501	Rhs element vgr protein
BRN66_18030	COG3179	chitinase
BRN66_18040	COG3501	Rhs element vgr protein
BRN66_18050	COG3039	Transposase
BRN66_18060	COG3501	Rhs element vgr protein
BRN66_18135	COG3501	Rhs element vgr protein
BRN66_18145	COG3039	Transposase
BRN66_18160	COG3039	Transposase
BRN66_18210	COG3501	Rhs element vgr protein
BRN66_18290	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BRN66_18305	COG2197	response regulator
BRN66_18310	COG4585	Histidine kinase
BRN66_18330	COG2894	cell division
BRN66_18335	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BRN66_18345	COG0642	Histidine kinase
BRN66_18350	COG0745	RESPONSE REGULATOR receiver
BRN66_18355	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BRN66_18365	COG2194	sulfuric ester hydrolase activity
BRN66_18395	COG3551	Protein conserved in bacteria
BRN66_18460	COG0203	ribosomal protein L17
BRN66_18465	COG0202	RNA polymerase activity
BRN66_18480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BRN66_18485	COG0201	protein transport
BRN66_18495	COG1841	ribosomal large subunit assembly
BRN66_18500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BRN66_18520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BRN66_18540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BRN66_18545	COG0255	Belongs to the universal ribosomal protein uL29 family
BRN66_18550	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BRN66_18575	COG0089	rRNA binding
BRN66_18620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BRN66_18660	COG0250	Participates in transcription elongation, termination and antitermination
BRN66_18665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BRN66_18695	COG0012	GTP binding
BRN66_18710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BRN66_18750	COG0521	Mo-molybdopterin cofactor biosynthetic process
BRN66_18770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRN66_18805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BRN66_18815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BRN66_18845	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BRN66_18850	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BRN66_18870	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BRN66_18885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRN66_18885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRN66_18935	COG2890	protein-(glutamine-N5) methyltransferase activity
BRN66_18945	COG3634	alkyl hydroperoxide reductase activity
BRN66_18950	COG0583	DNA-binding transcription factor activity
BRN66_18960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRN66_19040	COG4783	chaperone-mediated protein folding
BRN66_19055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BRN66_19065	COG0438	transferase activity, transferring glycosyl groups
BRN66_19070	COG0671	phosphoesterase, PA-phosphatase related
BRN66_19095	COG2833	Protein of unknown function (DUF455)
BRN66_19115	COG0285	dihydrofolate synthase activity
BRN66_19125	COG0406	alpha-ribazole phosphatase activity
BRN66_19160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BRN66_19165	COG4208	sulfate ABC transporter
BRN66_19170	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BRN66_19175	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BRN66_19180	COG0156	8-amino-7-oxononanoate synthase activity
BRN66_19215	COG0446	pyridine nucleotide-disulphide oxidoreductase
BRN66_19215	COG1902	pentaerythritol trinitrate reductase activity
BRN66_19265	COG3706	GGDEF domain
BRN66_19265	COG0745	RESPONSE REGULATOR receiver
BRN66_19350	COG3386	PFAM SMP-30 Gluconolaconase
BRN66_19370	COG1024	Enoyl-CoA hydratase
BRN66_19380	COG0318	PFAM AMP-dependent synthetase and ligase
BRN66_19385	COG0583	DNA-binding transcription factor activity
BRN66_19425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRN66_19430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BRN66_19440	COG2096	Adenosyltransferase
BRN66_19445	COG0123	including yeast histone deacetylase and acetoin utilization protein
BRN66_19460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BRN66_19520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BRN66_19545	COG0642	Histidine kinase
BRN66_19560	COG4181	ATPase activity
BRN66_19570	COG2175	clavaminate synthase activity
BRN66_19580	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BRN66_19620	COG0667	Aldo Keto reductase
BRN66_19630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BRN66_19635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRN66_19655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRN66_19670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BRN66_19730	COG2226	methyltransferase
BRN66_19785	COG0604	alcohol dehydrogenase
BRN66_19785	COG3321	synthase
BRN66_19785	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_19800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BRN66_19815	COG0494	nUDIX hydrolase
BRN66_19830	COG1388	LysM domain
BRN66_19830	COG4942	peptidase
BRN66_19855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BRN66_19860	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRN66_19880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRN66_19885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BRN66_19900	COG3116	cell division
BRN66_19945	COG1988	membrane-bound metal-dependent
BRN66_19950	COG0277	FAD linked oxidase domain protein
BRN66_19955	COG0745	RESPONSE REGULATOR receiver
BRN66_19960	COG2205	protein histidine kinase activity
BRN66_19970	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BRN66_19975	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BRN66_20000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BRN66_20030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRN66_20030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRN66_20070	COG0488	(ABC) transporter
BRN66_20115	COG0745	RESPONSE REGULATOR receiver
BRN66_20120	COG2205	protein histidine kinase activity
BRN66_20160	COG2205	protein histidine kinase activity
BRN66_20215	COG3039	Transposase
BRN66_20220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRN66_20235	COG3039	Transposase
BRN66_20290	COG3039	Transposase
BRN66_20340	COG1649	PFAM Uncharacterised BCR, COG1649
BRN66_20340	COG0726	polysaccharide deacetylase
BRN66_20345	COG1215	transferase activity, transferring glycosyl groups
BRN66_20355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BRN66_20360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BRN66_20365	COG1609	Transcriptional regulator
BRN66_20390	COG3250	beta-galactosidase activity
BRN66_20445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BRN66_20450	COG4191	Histidine kinase
BRN66_20455	COG0784	Response regulator, receiver
BRN66_20460	COG4251	negative regulation of phosphorylation
BRN66_20465	COG2823	Periplasmic or secreted lipoprotein
BRN66_20470	COG0673	inositol 2-dehydrogenase activity
BRN66_20475	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BRN66_20510	COG1051	belongs to the nudix hydrolase family
BRN66_20510	COG1056	cytidyltransferase-related domain
BRN66_20560	COG1686	Belongs to the peptidase S11 family
BRN66_20570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BRN66_20575	COG2951	lytic endotransglycosylase activity
BRN66_20590	COG1388	LysM domain
BRN66_20590	COG3409	Peptidoglycan-binding domain 1 protein
BRN66_20590	COG5632	N-Acetylmuramoyl-L-alanine amidase
BRN66_20635	COG0772	Belongs to the SEDS family
BRN66_20650	COG1792	Involved in formation and maintenance of cell shape
BRN66_20655	COG1077	Cell shape determining protein MreB Mrl
BRN66_20705	COG2199	diguanylate cyclase activity
BRN66_20710	COG0308	aminopeptidase N
BRN66_20740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BRN66_20785	COG1505	serine-type exopeptidase activity
BRN66_20820	COG3275	phosphorelay sensor kinase activity
BRN66_20865	COG0659	secondary active sulfate transmembrane transporter activity
BRN66_20870	COG5297	Belongs to the glycosyl hydrolase family 6
BRN66_20870	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRN66_20945	COG0598	Magnesium transport protein CorA
BRN66_20955	COG1113	amino acid transport
BRN66_20965	COG5297	Belongs to the glycosyl hydrolase family 6
BRN66_20970	COG4305	rare lipoprotein A
BRN66_20975	COG0697	spore germination
BRN66_21035	COG4221	oxidoreductase activity
BRN66_21065	COG0456	acetyltransferase
BRN66_21075	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BRN66_21135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BRN66_21135	COG2111	Na H antiporter
BRN66_21140	COG1006	Multisubunit Na H antiporter MnhC subunit
BRN66_21145	COG0651	ATP synthesis coupled electron transport
BRN66_21155	COG2212	antiporter activity
BRN66_21160	COG1320	monovalent cation:proton antiporter activity
BRN66_21190	COG3104	oligopeptide transport
BRN66_21205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BRN66_21240	COG0183	Belongs to the thiolase family
BRN66_21295	COG3039	Transposase
BRN66_21325	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BRN66_21330	COG3023	N-Acetylmuramoyl-L-alanine amidase
BRN66_21340	COG4948	Mandelate Racemase Muconate Lactonizing
BRN66_21380	COG0531	amino acid
BRN66_21415	COG4682	membrane
BRN66_21420	COG2133	pyrroloquinoline quinone binding
BRN66_21460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BRN66_21470	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BRN66_21475	COG1610	YqeY-like protein
BRN66_21490	COG1295	ribonuclease BN
BRN66_21495	COG0358	DNA primase activity
BRN66_21560	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BRN66_21575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BRN66_21745	COG3039	Transposase
BRN66_21760	COG3328	transposase activity
BRN66_21785	COG1473	amidohydrolase
BRN66_21790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRN66_21795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRN66_21810	COG5383	Protein conserved in bacteria
BRN66_21850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BRN66_21870	COG0028	Belongs to the TPP enzyme family
BRN66_21875	COG4191	Histidine kinase
BRN66_21900	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BRN66_21915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRN66_21920	COG3177	Filamentation induced by cAMP protein fic
BRN66_21935	COG0596	Alpha beta hydrolase
BRN66_21945	COG0318	PFAM AMP-dependent synthetase and ligase
BRN66_21950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRN66_22005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BRN66_22040	COG3039	Transposase
BRN66_22150	COG2353	YceI-like domain
BRN66_22180	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BRN66_22195	COG3386	PFAM SMP-30 Gluconolaconase
BRN66_22235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BRN66_22250	COG4771	TonB-dependent receptor
BRN66_22265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BRN66_22285	COG1252	NADH dehydrogenase
BRN66_22295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRN66_22305	COG3437	response regulator, receiver
BRN66_22310	COG2177	Part of the ABC transporter FtsEX involved in
BRN66_22315	COG2884	Cell division ATP-binding protein ftsE
BRN66_22325	COG3118	belongs to the thioredoxin family
BRN66_22330	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BRN66_22345	COG0729	surface antigen
BRN66_22350	COG2911	Protein conserved in bacteria
BRN66_22385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRN66_22400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRN66_22460	COG1733	regulation of RNA biosynthetic process
BRN66_22465	COG0702	epimerase
BRN66_22500	COG0583	DNA-binding transcription factor activity
BRN66_22505	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRN66_22525	COG0745	RESPONSE REGULATOR receiver
BRN66_22555	COG1902	pentaerythritol trinitrate reductase activity
BRN66_22560	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BRN66_22570	COG2814	Major facilitator Superfamily
BRN66_22575	COG0583	DNA-binding transcription factor activity
BRN66_22595	COG0084	hydrolase, TatD family'
BRN66_22645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRN66_22720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BRN66_22725	COG1960	acyl-CoA dehydrogenase activity
BRN66_22780	COG0523	cobalamin synthesis protein
BRN66_22790	COG0697	spore germination
BRN66_22800	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BRN66_22815	COG4771	TonB-dependent receptor
BRN66_22820	COG0457	Tetratricopeptide repeat
BRN66_22835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BRN66_22865	COG0519	Catalyzes the synthesis of GMP from XMP
BRN66_22865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRN66_22875	COG0805	protein transport
BRN66_22885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BRN66_22895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BRN66_22950	COG3661	Belongs to the glycosyl hydrolase 67 family
BRN66_22960	COG4948	Mandelate Racemase Muconate Lactonizing
BRN66_22970	COG1472	Belongs to the glycosyl hydrolase 3 family
BRN66_22975	COG0246	Mannitol dehydrogenase
BRN66_23000	COG3693	PFAM glycoside hydrolase, family 10
BRN66_23025	COG2211	Major facilitator Superfamily
BRN66_23070	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BRN66_23120	COG1846	Transcriptional regulator
BRN66_23125	COG1764	response to oxidative stress
BRN66_23225	COG3549	Plasmid maintenance system killer
BRN66_23235	COG1074	ATP-dependent DNA helicase activity
BRN66_23240	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BRN66_23280	COG2032	superoxide dismutase activity
BRN66_23285	COG2032	superoxide dismutase activity
BRN66_23290	COG2204	response regulator
BRN66_23295	COG3852	Histidine kinase
BRN66_23300	COG0004	ammonium transporteR
BRN66_23305	COG0347	Belongs to the P(II) protein family
BRN66_23310	COG0174	glutamine synthetase
BRN66_23360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN66_23370	COG2062	phosphohistidine phosphatase, SixA
BRN66_23375	COG0489	protein tyrosine kinase activity
BRN66_23395	COG1396	sequence-specific DNA binding
BRN66_23400	COG3550	peptidyl-serine autophosphorylation
BRN66_23405	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BRN66_23410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BRN66_23425	COG1125	glycine betaine transport
BRN66_23425	COG0517	IMP dehydrogenase activity
BRN66_23440	COG1119	ATPase activity
BRN66_23450	COG1752	Esterase of the alpha-beta hydrolase superfamily
BRN66_23465	COG3039	Transposase
BRN66_23490	COG0656	L-ascorbic acid biosynthetic process
BRN66_23495	COG2130	NADP-dependent
BRN66_23500	COG0667	Aldo Keto reductase
BRN66_23510	COG1187	pseudouridine synthase activity
BRN66_23525	COG1643	Atp-dependent helicase
BRN66_23530	COG4807	Protein conserved in bacteria
BRN66_23535	COG4948	Mandelate Racemase Muconate Lactonizing
BRN66_23545	COG0179	Fumarylacetoacetate (FAA) hydrolase
BRN66_23550	COG1028	Short-chain dehydrogenase reductase Sdr
BRN66_23570	COG3507	Belongs to the glycosyl hydrolase 43 family
BRN66_23615	COG3162	membrane
BRN66_23620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BRN66_23635	COG0708	Exodeoxyribonuclease III
BRN66_23650	COG2091	lysine biosynthetic process via aminoadipic acid
BRN66_23660	COG3540	Alkaline phosphatase
BRN66_23680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BRN66_23685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BRN66_23690	COG2159	amidohydrolase
BRN66_23715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BRN66_23720	COG0583	DNA-binding transcription factor activity
BRN66_23725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRN66_23745	COG0210	DNA helicase
BRN66_23760	COG0531	amino acid
BRN66_23770	COG1322	Protein conserved in bacteria
BRN66_23780	COG0386	Belongs to the glutathione peroxidase family
BRN66_23835	COG0793	Belongs to the peptidase S41A family
BRN66_23840	COG4942	peptidase
BRN66_23850	COG2234	aminopeptidase activity
BRN66_23900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRN66_23905	COG0302	gtp cyclohydrolase
BRN66_23930	COG0477	Major facilitator Superfamily
BRN66_24035	COG1929	Belongs to the glycerate kinase type-1 family
BRN66_24040	COG2271	Major facilitator Superfamily
BRN66_24055	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRN66_24065	COG0861	Integral membrane protein TerC family
BRN66_24075	COG0584	glycerophosphoryl diester phosphodiesterase
BRN66_24085	COG0671	phosphoesterase, PA-phosphatase related
BRN66_24095	COG0726	polysaccharide deacetylase
BRN66_24110	COG0230	Belongs to the bacterial ribosomal protein bL34 family