locus-tag	class	description
GHV42_00020	COG0187	DNA topoisomerase II activity
GHV42_00030	COG0501	Belongs to the peptidase M48B family
GHV42_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GHV42_00085	COG1064	alcohol dehydrogenase
GHV42_00090	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GHV42_00095	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GHV42_00105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GHV42_00115	COG2234	aminopeptidase activity
GHV42_00125	COG4942	peptidase
GHV42_00130	COG0793	Belongs to the peptidase S41A family
GHV42_00195	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GHV42_00210	COG0210	DNA helicase
GHV42_00230	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GHV42_00265	COG2937	Belongs to the GPAT DAPAT family
GHV42_00310	COG2211	Major facilitator Superfamily
GHV42_00330	COG3693	PFAM glycoside hydrolase, family 10
GHV42_00370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GHV42_00375	COG1960	acyl-CoA dehydrogenase activity
GHV42_00420	COG0523	cobalamin synthesis protein
GHV42_00445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GHV42_00450	COG1846	Transcriptional regulator
GHV42_00455	COG1764	response to oxidative stress
GHV42_00485	COG0656	L-ascorbic acid biosynthetic process
GHV42_00490	COG2130	NADP-dependent
GHV42_00495	COG0667	Aldo Keto reductase
GHV42_00505	COG1187	pseudouridine synthase activity
GHV42_00515	COG1643	Atp-dependent helicase
GHV42_00525	COG4807	Protein conserved in bacteria
GHV42_00530	COG2072	flavoprotein involved in K transport
GHV42_00550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GHV42_00590	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GHV42_00660	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GHV42_00665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GHV42_00675	COG3485	protocatechuate 3,4-dioxygenase
GHV42_00680	COG3485	protocatechuate 3,4-dioxygenase
GHV42_00695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GHV42_00700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GHV42_00715	COG1414	Transcriptional regulator
GHV42_00795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GHV42_00845	COG1040	competence protein
GHV42_00850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GHV42_00875	COG2911	Protein conserved in bacteria
GHV42_00880	COG0729	surface antigen
GHV42_00885	COG4771	TonB-dependent receptor
GHV42_00895	COG0457	Tetratricopeptide repeat
GHV42_00905	COG0752	glycyl-tRNA synthetase alpha subunit
GHV42_00910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GHV42_00920	COG3039	Transposase
GHV42_00925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GHV42_00925	COG0519	Catalyzes the synthesis of GMP from XMP
GHV42_00935	COG0805	protein transport
GHV42_00940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GHV42_00945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GHV42_00955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GHV42_00980	COG2974	May be involved in recombination
GHV42_01000	COG3661	Belongs to the glycosyl hydrolase 67 family
GHV42_01010	COG4948	Mandelate Racemase Muconate Lactonizing
GHV42_01020	COG1472	Belongs to the glycosyl hydrolase 3 family
GHV42_01025	COG0246	Mannitol dehydrogenase
GHV42_01115	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GHV42_01190	COG1511	domain protein
GHV42_01190	COG3264	Mechanosensitive ion channel
GHV42_01205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GHV42_01210	COG2354	Protein conserved in bacteria
GHV42_01220	COG3706	GGDEF domain
GHV42_01220	COG0745	RESPONSE REGULATOR receiver
GHV42_01235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GHV42_01260	COG0702	epimerase
GHV42_01285	COG3039	Transposase
GHV42_01320	COG3501	Rhs element vgr protein
GHV42_01365	COG3501	Rhs element vgr protein
GHV42_01405	COG0084	hydrolase, TatD family'
GHV42_01425	COG2814	Major facilitator Superfamily
GHV42_01435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GHV42_01470	COG0745	RESPONSE REGULATOR receiver
GHV42_01490	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GHV42_01495	COG0583	DNA-binding transcription factor activity
GHV42_01520	COG1733	regulation of RNA biosynthetic process
GHV42_01525	COG0702	epimerase
GHV42_01565	COG0583	DNA-binding transcription factor activity
GHV42_01605	COG1199	ATP-dependent helicase activity
GHV42_01610	COG3039	Transposase
GHV42_01640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GHV42_01650	COG0745	RESPONSE REGULATOR receiver
GHV42_01655	COG2205	protein histidine kinase activity
GHV42_01670	COG3228	Belongs to the MtfA family
GHV42_01680	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GHV42_01680	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GHV42_01730	COG3237	CsbD-like
GHV42_01735	COG0180	Tryptophanyl-tRNA synthetase
GHV42_01740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHV42_01785	COG0753	catalase activity
GHV42_01800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GHV42_01835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GHV42_01845	COG0642	Histidine kinase
GHV42_01855	COG1090	epimerase
GHV42_01895	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GHV42_01915	COG0606	chelatase, subunit chli
GHV42_02005	COG1166	arginine decarboxylase activity
GHV42_02020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GHV42_02020	COG2755	lipolytic protein G-D-S-L family
GHV42_02025	COG4221	oxidoreductase activity
GHV42_02050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GHV42_02075	COG0463	Glycosyl transferase, family 2
GHV42_02090	COG1475	DNA binding
GHV42_02095	COG1192	Involved in chromosome partitioning
GHV42_02125	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GHV42_02135	COG0456	acetyltransferase
GHV42_02175	COG0134	indole-3-glycerol-phosphate synthase activity
GHV42_02185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GHV42_02205	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GHV42_02280	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GHV42_02295	COG2814	Major facilitator Superfamily
GHV42_02310	COG1289	transmembrane transporter activity
GHV42_02320	COG1136	(ABC) transporter
GHV42_02320	COG0577	efflux transmembrane transporter activity
GHV42_02325	COG0151	Belongs to the GarS family
GHV42_02330	COG0138	bifunctional purine biosynthesis protein purh
GHV42_02360	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GHV42_02400	COG0439	Biotin carboxylase
GHV42_02410	COG0511	ligase activity, forming carbon-carbon bonds
GHV42_02430	COG1324	tolerance protein
GHV42_02435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GHV42_02455	COG0534	Mate efflux family protein
GHV42_02460	COG0616	signal peptide processing
GHV42_02470	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_02490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GHV42_02490	COG1754	DNA topoisomerase type I activity
GHV42_02510	COG0758	DNA mediated transformation
GHV42_02515	COG1652	LysM domain
GHV42_02520	COG0242	peptide deformylase activity
GHV42_02530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GHV42_02530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GHV42_02575	COG1560	Kdo2-lipid A biosynthetic process
GHV42_02585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GHV42_02625	COG0625	glutathione transferase activity
GHV42_02670	COG4555	ABC transporter
GHV42_02680	COG1476	TRANSCRIPTIONal
GHV42_02705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GHV42_02710	COG1131	(ABC) transporter
GHV42_02715	COG0842	Transport permease protein
GHV42_02725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GHV42_02745	COG3039	Transposase
GHV42_02755	COG3039	Transposase
GHV42_02765	COG2951	lytic endotransglycosylase activity
GHV42_02800	COG2831	hemolysin activation secretion protein
GHV42_02805	COG3210	domain, Protein
GHV42_02805	COG3210	domain, Protein
GHV42_02815	COG3039	Transposase
GHV42_02830	COG2826	transposase and inactivated derivatives, IS30 family
GHV42_02855	COG3210	domain, Protein
GHV42_02860	COG3039	Transposase
GHV42_02930	COG2353	YceI-like domain
GHV42_02960	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GHV42_02995	COG2201	protein-glutamate methylesterase activity
GHV42_03055	COG1063	alcohol dehydrogenase
GHV42_03085	COG1294	oxidase, subunit
GHV42_03090	COG1271	oxidase subunit
GHV42_03125	COG2972	Histidine kinase
GHV42_03140	COG0531	amino acid
GHV42_03160	COG3590	peptidase
GHV42_03170	COG0667	Aldo Keto reductase
GHV42_03185	COG3384	dioxygenase
GHV42_03195	COG1573	uracil-dna glycosylase
GHV42_03205	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GHV42_03210	COG0025	NhaP-type Na H and K H
GHV42_03215	COG1131	(ABC) transporter
GHV42_03220	COG0842	Transport permease protein
GHV42_03235	COG1404	Belongs to the peptidase S8 family
GHV42_03250	COG0745	RESPONSE REGULATOR receiver
GHV42_03295	COG1522	sequence-specific DNA binding
GHV42_03300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHV42_03325	COG2205	protein histidine kinase activity
GHV42_03325	COG2202	Pas domain
GHV42_03355	COG2813	Specifically methylates the guanine in position
GHV42_03360	COG1187	pseudouridine synthase activity
GHV42_03365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GHV42_03400	COG0697	spore germination
GHV42_03410	COG2011	ABC-type metal ion transport system permease component
GHV42_03445	COG0508	dehydrogenase complex catalyzes the overall conversion of
GHV42_03455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GHV42_03475	COG0356	it plays a direct role in the translocation of protons across the membrane
GHV42_03530	COG4191	Histidine kinase
GHV42_03545	COG0577	efflux transmembrane transporter activity
GHV42_03545	COG1136	(ABC) transporter
GHV42_03560	COG1136	(ABC) transporter
GHV42_03565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHV42_03570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GHV42_03620	COG0339	signal peptide processing
GHV42_03650	COG0546	phosphoglycolate phosphatase activity
GHV42_03660	COG1956	GAF domain-containing protein
GHV42_03675	COG0720	synthase
GHV42_03680	COG0513	Belongs to the DEAD box helicase family
GHV42_03695	COG0625	glutathione transferase activity
GHV42_03725	COG0626	cystathionine gamma-synthase activity
GHV42_03740	COG0110	maltose O-acetyltransferase activity
GHV42_03745	COG0438	transferase activity, transferring glycosyl groups
GHV42_03745	COG1216	Glycosyl transferase, family 2
GHV42_03750	COG3754	Rhamnan synthesis protein F
GHV42_03760	COG2226	methyltransferase
GHV42_03780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GHV42_03795	COG0277	FAD linked oxidase domain protein
GHV42_03800	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GHV42_03800	COG0546	phosphoglycolate phosphatase activity
GHV42_03815	COG2086	electron transfer activity
GHV42_03840	COG0662	Cupin 2, conserved barrel domain protein
GHV42_03840	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GHV42_03845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GHV42_03885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GHV42_03885	COG3218	ABC-type transport auxiliary lipoprotein component
GHV42_03890	COG1127	ABC transporter
GHV42_03895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GHV42_03920	COG1183	phosphatidylcholine synthase activity
GHV42_03935	COG2826	transposase and inactivated derivatives, IS30 family
GHV42_03960	COG0525	valine-tRNA ligase activity
GHV42_03985	COG0795	lipopolysaccharide-transporting ATPase activity
GHV42_04000	COG4974	Belongs to the 'phage' integrase family
GHV42_04005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GHV42_04010	COG0047	phosphoribosylformylglycinamidine synthase activity
GHV42_04010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GHV42_04015	COG5295	Hep Hag repeat protein
GHV42_04020	COG1404	Belongs to the peptidase S8 family
GHV42_04025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GHV42_04035	COG1459	type II secretion system
GHV42_04040	COG2165	general secretion pathway protein
GHV42_04045	COG4970	Tfp pilus assembly protein FimT
GHV42_04050	COG2165	general secretion pathway protein
GHV42_04055	COG4795	General secretion pathway protein
GHV42_04060	COG3156	type II secretion system protein K
GHV42_04065	COG3166	PFAM Fimbrial assembly family protein
GHV42_04080	COG1450	Type ii and iii secretion system protein
GHV42_04095	COG2188	Transcriptional regulator
GHV42_04145	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GHV42_04175	COG0242	peptide deformylase activity
GHV42_04210	COG1228	amidohydrolase
GHV42_04215	COG3964	amidohydrolase
GHV42_04235	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GHV42_04240	COG0726	polysaccharide deacetylase
GHV42_04260	COG0436	Aminotransferase
GHV42_04290	COG2211	Major facilitator Superfamily
GHV42_04300	COG1609	Transcriptional regulator
GHV42_04305	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_04310	COG2851	Citrate transporter
GHV42_04325	COG0642	Histidine kinase
GHV42_04330	COG1840	ABC-type Fe3 transport system, periplasmic component
GHV42_04335	COG2197	response regulator
GHV42_04350	COG0583	DNA-binding transcription factor activity
GHV42_04365	COG4191	Histidine kinase
GHV42_04385	COG0281	malic enzyme
GHV42_04385	COG0280	phosphate acetyltransferase
GHV42_04410	COG1560	Kdo2-lipid A biosynthetic process
GHV42_04415	COG1519	Transferase
GHV42_04420	COG1538	Outer membrane efflux protein
GHV42_04425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GHV42_04455	COG2226	methyltransferase
GHV42_04500	COG3710	Transcriptional regulator
GHV42_04525	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GHV42_04535	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GHV42_04570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GHV42_04580	COG3781	membrane
GHV42_04630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GHV42_04635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GHV42_04690	COG0352	thiamine-phosphate diphosphorylase activity
GHV42_04695	COG1773	rubredoxin
GHV42_04700	COG2912	Transglutaminase-like superfamily
GHV42_04720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GHV42_04745	COG0006	proline dipeptidase activity
GHV42_04775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GHV42_04785	COG0346	lactoylglutathione lyase activity
GHV42_04795	COG1561	YicC-like family, N-terminal region
GHV42_04810	COG1758	RNA polymerase activity
GHV42_04815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GHV42_04825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GHV42_04835	COG0254	rRNA binding
GHV42_04855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GHV42_04890	COG0714	Associated with various cellular activities
GHV42_04910	COG2304	oxidoreductase activity
GHV42_04945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GHV42_05045	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GHV42_05050	COG4149	molybdate abc transporter
GHV42_05055	COG0725	ABC transporter, periplasmic molybdate-binding protein
GHV42_05060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHV42_05060	COG3453	Protein conserved in bacteria
GHV42_05070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GHV42_05080	COG0126	phosphoglycerate kinase activity
GHV42_05090	COG0469	pyruvate kinase activity
GHV42_05095	COG3588	fructose-bisphosphate aldolase
GHV42_05100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GHV42_05140	COG2198	Histidine kinase
GHV42_05140	COG0784	Response regulator, receiver
GHV42_05140	COG2205	protein histidine kinase activity
GHV42_05170	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GHV42_05180	COG0529	Catalyzes the synthesis of activated sulfate
GHV42_05180	COG2895	sulfate adenylyltransferase (ATP) activity
GHV42_05190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GHV42_05195	COG0308	aminopeptidase N
GHV42_05215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GHV42_05240	COG1970	mechanosensitive ion channel activity
GHV42_05265	COG3273	potassium ion transport
GHV42_05265	COG0471	metal ion transport
GHV42_05350	COG1074	ATP-dependent DNA helicase activity
GHV42_05360	COG3039	Transposase
GHV42_05415	COG2003	Belongs to the UPF0758 family
GHV42_05450	COG0084	hydrolase, TatD family'
GHV42_05530	COG0745	RESPONSE REGULATOR receiver
GHV42_05555	COG3039	Transposase
GHV42_05565	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GHV42_05575	COG4969	Belongs to the N-Me-Phe pilin family
GHV42_05580	COG2194	sulfuric ester hydrolase activity
GHV42_05625	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GHV42_05635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GHV42_05635	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GHV42_05640	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GHV42_05645	COG0564	pseudouridine synthase activity
GHV42_05660	COG3011	Protein conserved in bacteria
GHV42_05665	COG0840	transmembrane signaling receptor activity
GHV42_05680	COG3387	PFAM Glycoside hydrolase 15-related
GHV42_05685	COG1877	trehalose-phosphatase activity
GHV42_05740	COG1595	DNA-templated transcription, initiation
GHV42_05750	COG1946	Acyl-CoA thioesterase
GHV42_05765	COG0824	Thioesterase
GHV42_05770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GHV42_05790	COG0268	Binds directly to 16S ribosomal RNA
GHV42_05795	COG0728	peptidoglycan biosynthetic process
GHV42_05800	COG0196	riboflavin kinase activity
GHV42_05810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GHV42_05830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GHV42_05835	COG1845	cytochrome c oxidase, subunit III
GHV42_05840	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GHV42_05850	COG3501	Rhs element vgr protein
GHV42_05890	COG3039	Transposase
GHV42_05935	COG2207	Transcriptional regulator
GHV42_05940	COG0326	Molecular chaperone. Has ATPase activity
GHV42_05950	COG1366	Belongs to the anti-sigma-factor antagonist family
GHV42_05955	COG1366	Belongs to the anti-sigma-factor antagonist family
GHV42_05960	COG2172	sigma factor antagonist activity
GHV42_06000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GHV42_06005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GHV42_06020	COG2070	2-Nitropropane dioxygenase
GHV42_06055	COG0534	Mate efflux family protein
GHV42_06065	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GHV42_06090	COG0542	response to heat
GHV42_06140	COG0019	diaminopimelate decarboxylase activity
GHV42_06150	COG2814	Major facilitator Superfamily
GHV42_06155	COG4264	IucA IucC family
GHV42_06165	COG4772	TonB-dependent receptor
GHV42_06180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GHV42_06180	COG4651	solute:proton antiporter activity
GHV42_06210	COG0488	(ABC) transporter
GHV42_06235	COG2755	lipolytic protein G-D-S-L family
GHV42_06235	COG0657	acetylesterase activity
GHV42_06250	COG0477	Major facilitator Superfamily
GHV42_06265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GHV42_06305	COG0824	Thioesterase
GHV42_06325	COG0823	Involved in the tonB-independent uptake of proteins
GHV42_06330	COG2885	chlorophyll binding
GHV42_06340	COG0602	queuosine metabolic process
GHV42_06355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GHV42_06395	COG4695	Portal protein
GHV42_06440	COG3179	chitinase
GHV42_06655	COG1187	pseudouridine synthase activity
GHV42_06675	COG0514	ATP-dependent DNA helicase (RecQ)
GHV42_06680	COG0783	Belongs to the Dps family
GHV42_06685	COG1643	Atp-dependent helicase
GHV42_06695	COG0837	glucose binding
GHV42_06700	COG0837	glucose binding
GHV42_06740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GHV42_06755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GHV42_06765	COG1199	ATP-dependent helicase activity
GHV42_06785	COG0189	ligase activity
GHV42_06800	COG0835	chemotaxis
GHV42_06805	COG0840	transmembrane signaling receptor activity
GHV42_06865	COG3501	Rhs element vgr protein
GHV42_06885	COG2304	oxidoreductase activity
GHV42_06890	COG1446	asparaginase
GHV42_06935	COG3537	Alpha-1,2-mannosidase
GHV42_07000	COG1472	Belongs to the glycosyl hydrolase 3 family
GHV42_07015	COG3858	chitin binding
GHV42_07015	COG1388	LysM domain
GHV42_07030	COG0837	glucose binding
GHV42_07035	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GHV42_07045	COG0494	nUDIX hydrolase
GHV42_07055	COG3956	TIGRFAM MazG family protein
GHV42_07060	COG1742	UPF0060 membrane protein
GHV42_07070	COG0330	HflC and HflK could
GHV42_07120	COG1960	acyl-CoA dehydrogenase activity
GHV42_07130	COG1309	transcriptional regulator
GHV42_07135	COG4771	TonB-dependent receptor
GHV42_07145	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GHV42_07155	COG0463	Glycosyl transferase, family 2
GHV42_07160	COG0517	IMP dehydrogenase activity
GHV42_07160	COG0516	GMP reductase activity
GHV42_07170	COG1272	protein, Hemolysin III
GHV42_07180	COG0739	heme binding
GHV42_07185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GHV42_07190	COG0626	cystathionine gamma-synthase activity
GHV42_07200	COG1760	l-serine dehydratase
GHV42_07225	COG2353	YceI-like domain
GHV42_07235	COG5002	protein histidine kinase activity
GHV42_07235	COG0784	Response regulator, receiver
GHV42_07275	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GHV42_07295	COG1960	acyl-CoA dehydrogenase activity
GHV42_07335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GHV42_07345	COG0681	Belongs to the peptidase S26 family
GHV42_07385	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GHV42_07390	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
GHV42_07395	COG3046	protein related to deoxyribodipyrimidine photolyase
GHV42_07410	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GHV42_07415	COG1278	Cold shock
GHV42_07435	COG1201	RNA secondary structure unwinding
GHV42_07440	COG1793	dna ligase
GHV42_07450	COG1793	dna ligase
GHV42_07450	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GHV42_07465	COG3706	GGDEF domain
GHV42_07480	COG0183	Belongs to the thiolase family
GHV42_07500	COG1451	nucleotide metabolic process
GHV42_07515	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GHV42_07525	COG3039	Transposase
GHV42_07565	COG1047	Peptidyl-prolyl cis-trans
GHV42_07575	COG2824	Alkylphosphonate utilization operon protein PhnA
GHV42_07590	COG1902	pentaerythritol trinitrate reductase activity
GHV42_07595	COG2814	Major facilitator Superfamily
GHV42_07630	COG0392	lysyltransferase activity
GHV42_07630	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GHV42_07640	COG0251	oxidation-reduction process
GHV42_07645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GHV42_07660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GHV42_07685	COG1595	DNA-templated transcription, initiation
GHV42_07700	COG2878	Part of a membrane complex involved in electron transport
GHV42_07720	COG0346	lactoylglutathione lyase activity
GHV42_07725	COG0833	amino acid
GHV42_07730	COG2040	homocysteine
GHV42_07745	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GHV42_07765	COG1695	Transcriptional regulator
GHV42_07815	COG0825	malonyl-CoA metabolic process
GHV42_07845	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GHV42_07850	COG3039	Transposase
GHV42_07860	COG0750	zinc metalloprotease
GHV42_07865	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GHV42_07870	COG0575	Belongs to the CDS family
GHV42_07890	COG3706	GGDEF domain
GHV42_07890	COG0745	RESPONSE REGULATOR receiver
GHV42_07935	COG0024	Methionine aminopeptidase
GHV42_07955	COG1393	Belongs to the ArsC family
GHV42_07965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GHV42_07970	COG0367	asparagine synthase
GHV42_07980	COG4774	siderophore transport
GHV42_08000	COG2207	Transcriptional regulator
GHV42_08015	COG1566	PFAM secretion protein HlyD family protein
GHV42_08020	COG2814	Major facilitator Superfamily
GHV42_08125	COG0386	Belongs to the glutathione peroxidase family
GHV42_08190	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GHV42_08195	COG0084	hydrolase, TatD family'
GHV42_08210	COG1960	acyl-CoA dehydrogenase activity
GHV42_08225	COG0367	asparagine synthase
GHV42_08235	COG0305	Participates in initiation and elongation during chromosome replication
GHV42_08240	COG0415	Belongs to the DNA photolyase family
GHV42_08255	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_08265	COG3706	GGDEF domain
GHV42_08275	COG3706	GGDEF domain
GHV42_08290	COG0489	protein tyrosine kinase activity
GHV42_08320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GHV42_08335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GHV42_08350	COG3039	Transposase
GHV42_08355	COG0433	COG0433 Predicted ATPase
GHV42_08380	COG2890	protein-(glutamine-N5) methyltransferase activity
GHV42_08390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GHV42_08395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GHV42_08430	COG0133	tryptophan synthase activity
GHV42_08485	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_08505	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHV42_08525	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GHV42_08530	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GHV42_08535	COG1034	ATP synthesis coupled electron transport
GHV42_08540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GHV42_08555	COG0713	ATP synthesis coupled electron transport
GHV42_08570	COG1007	ATP synthesis coupled electron transport
GHV42_08585	COG0195	Participates in both transcription termination and antitermination
GHV42_08590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GHV42_08605	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GHV42_08640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GHV42_08645	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GHV42_08655	COG2095	MarC family integral membrane protein
GHV42_08670	COG1611	Belongs to the LOG family
GHV42_08710	COG4969	Belongs to the N-Me-Phe pilin family
GHV42_08715	COG0556	nucleotide-excision repair
GHV42_08760	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GHV42_08770	COG2986	histidine ammonia-lyase
GHV42_08815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GHV42_08820	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GHV42_08825	COG0077	Prephenate dehydratase
GHV42_08825	COG1605	Chorismate mutase
GHV42_08850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GHV42_08855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GHV42_08860	COG0583	DNA-binding transcription factor activity
GHV42_08900	COG3039	Transposase
GHV42_08940	COG0840	transmembrane signaling receptor activity
GHV42_08955	COG5002	protein histidine kinase activity
GHV42_08955	COG2205	protein histidine kinase activity
GHV42_08955	COG0784	Response regulator, receiver
GHV42_08960	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
GHV42_08970	COG0784	Response regulator, receiver
GHV42_08970	COG4191	Histidine kinase
GHV42_08975	COG4191	Histidine kinase
GHV42_08975	COG0784	Response regulator, receiver
GHV42_08990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GHV42_09010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GHV42_09025	COG1595	DNA-templated transcription, initiation
GHV42_09075	COG2244	polysaccharide biosynthetic process
GHV42_09105	COG2264	protein methyltransferase activity
GHV42_09115	COG0438	transferase activity, transferring glycosyl groups
GHV42_09135	COG1132	(ABC) transporter
GHV42_09145	COG0477	Major facilitator Superfamily
GHV42_09155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHV42_09170	COG1253	flavin adenine dinucleotide binding
GHV42_09220	COG0148	phosphopyruvate hydratase activity
GHV42_09265	COG1238	metal cluster binding
GHV42_09280	COG1534	Rna-binding protein
GHV42_09290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GHV42_09295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GHV42_09305	COG1923	regulation of RNA biosynthetic process
GHV42_09310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GHV42_09315	COG1546	Belongs to the CinA family
GHV42_09335	COG2137	regulation of response to DNA damage stimulus
GHV42_09345	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GHV42_09360	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GHV42_09380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GHV42_09390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GHV42_09405	COG2166	iron-sulfur cluster assembly
GHV42_09420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GHV42_09425	COG0137	argininosuccinate synthase activity
GHV42_09435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GHV42_09440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GHV42_09505	COG1271	oxidase subunit
GHV42_09515	COG4988	ABC transporter
GHV42_09520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GHV42_09580	COG4133	protoheme IX ABC transporter activity
GHV42_09585	COG0436	Aminotransferase
GHV42_09605	COG1187	pseudouridine synthase activity
GHV42_09610	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GHV42_09615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GHV42_09620	COG2350	Protein conserved in bacteria
GHV42_09650	COG1175	transmembrane transport
GHV42_09655	COG0395	ABC-type sugar transport system, permease component
GHV42_09680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GHV42_09690	COG2957	Belongs to the agmatine deiminase family
GHV42_09700	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GHV42_09705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GHV42_09710	COG0539	negative regulation of cytoplasmic translation
GHV42_09725	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GHV42_09730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GHV42_09740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GHV42_09765	COG0519	Catalyzes the synthesis of GMP from XMP
GHV42_09765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GHV42_09775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GHV42_09780	COG0583	DNA-binding transcription factor activity
GHV42_09805	COG0583	DNA-binding transcription factor activity
GHV42_09810	COG0583	DNA-binding transcription factor activity
GHV42_09825	COG2201	protein-glutamate methylesterase activity
GHV42_09830	COG1914	H( )-stimulated, divalent metal cation uptake system
GHV42_09835	COG1321	iron dependent repressor
GHV42_09840	COG0590	tRNA wobble adenosine to inosine editing
GHV42_09850	COG0668	transmembrane transport
GHV42_09875	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_09880	COG1183	phosphatidylcholine synthase activity
GHV42_09890	COG3243	poly(R)-hydroxyalkanoic acid synthase
GHV42_09905	COG0723	plastoquinol--plastocyanin reductase activity
GHV42_09905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHV42_09915	COG2183	response to ionizing radiation
GHV42_09925	COG2205	protein histidine kinase activity
GHV42_09925	COG0784	Response regulator, receiver
GHV42_10050	COG3039	Transposase
GHV42_10070	COG3039	Transposase
GHV42_10075	COG0800	Aldolase
GHV42_10080	COG0129	dihydroxy-acid dehydratase activity
GHV42_10085	COG0363	glucosamine-6-phosphate deaminase activity
GHV42_10095	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GHV42_10110	COG0354	folic acid binding
GHV42_10125	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GHV42_10140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GHV42_10155	COG4591	ABC-type transport system involved in lipoprotein release permease component
GHV42_10180	COG0811	peptide transport
GHV42_10205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GHV42_10265	COG3039	Transposase
GHV42_10305	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GHV42_10335	COG1530	ribonuclease E activity
GHV42_10345	COG3064	Membrane
GHV42_10365	COG2154	pterin-4-alpha-carbinolamine dehydratase
GHV42_10415	COG3501	Rhs element vgr protein
GHV42_10430	COG3501	Rhs element vgr protein
GHV42_10435	COG3039	Transposase
GHV42_10465	COG3039	Transposase
GHV42_10490	COG3039	Transposase
GHV42_10530	COG3501	Rhs element vgr protein
GHV42_10595	COG3501	Rhs element vgr protein
GHV42_10630	COG0631	protein serine/threonine phosphatase activity
GHV42_10635	COG0515	serine threonine protein kinase
GHV42_10665	COG1858	cytochrome C peroxidase
GHV42_10715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHV42_10720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GHV42_10775	COG2201	protein-glutamate methylesterase activity
GHV42_10815	COG4566	intracellular signal transduction
GHV42_10825	COG5001	Diguanylate cyclase
GHV42_10875	COG1648	precorrin-2 dehydrogenase activity
GHV42_10875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GHV42_10900	COG0746	molybdenum cofactor guanylyltransferase activity
GHV42_10935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GHV42_10950	COG0303	'Molybdopterin
GHV42_10955	COG1160	GTP binding
GHV42_10960	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GHV42_10985	COG0105	UTP biosynthetic process
GHV42_10995	COG1024	Enoyl-CoA hydratase
GHV42_10995	COG1250	3-hydroxyacyl-CoA dehydrogenase
GHV42_11000	COG0183	Belongs to the thiolase family
GHV42_11005	COG0038	chloride channel
GHV42_11025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GHV42_11045	COG1674	ftsk spoiiie
GHV42_11050	COG0492	ferredoxin-NADP+ reductase activity
GHV42_11070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GHV42_11075	COG0542	response to heat
GHV42_11080	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GHV42_11090	COG0482	sulfurtransferase activity
GHV42_11120	COG4585	Histidine kinase
GHV42_11130	COG4191	Histidine kinase
GHV42_11150	COG0784	Response regulator, receiver
GHV42_11150	COG0835	chemotaxis
GHV42_11160	COG1558	bacterial-type flagellum-dependent cell motility
GHV42_11165	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GHV42_11170	COG1749	Flagellar hook protein flgE
GHV42_11175	COG4787	bacterial-type flagellum-dependent cell motility
GHV42_11180	COG4786	Flagellar basal body rod
GHV42_11195	COG3951	Flagellar rod assembly protein muramidase FlgJ
GHV42_11195	COG1705	Flagellar rod assembly protein muramidase FlgJ
GHV42_11210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GHV42_11215	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GHV42_11245	COG2201	protein-glutamate methylesterase activity
GHV42_11250	COG2204	response regulator
GHV42_11265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GHV42_11270	COG4221	oxidoreductase activity
GHV42_11275	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_11315	COG1677	Flagellar hook-basal body complex protein FliE
GHV42_11365	COG3190	flagellar
GHV42_11375	COG1987	bacterial-type flagellum assembly
GHV42_11380	COG1684	flagellar biosynthetic protein fliR
GHV42_11385	COG3300	MHYT domain
GHV42_11385	COG5001	Diguanylate cyclase
GHV42_11390	COG5001	Diguanylate cyclase
GHV42_11390	COG3300	MHYT domain
GHV42_11415	COG0455	bacterial-type flagellum organization
GHV42_11435	COG2198	Histidine kinase
GHV42_11435	COG0643	Histidine kinase
GHV42_11580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GHV42_11595	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GHV42_11600	COG1360	Flagellar Motor Protein
GHV42_11605	COG1192	Involved in chromosome partitioning
GHV42_11610	COG0835	chemotaxis
GHV42_11620	COG0745	RESPONSE REGULATOR receiver
GHV42_11630	COG0840	transmembrane signaling receptor activity
GHV42_11655	COG0840	transmembrane signaling receptor activity
GHV42_11660	COG0840	transmembrane signaling receptor activity
GHV42_11665	COG0840	transmembrane signaling receptor activity
GHV42_11675	COG0840	transmembrane signaling receptor activity
GHV42_11680	COG0840	transmembrane signaling receptor activity
GHV42_11685	COG0840	transmembrane signaling receptor activity
GHV42_11690	COG0840	transmembrane signaling receptor activity
GHV42_11700	COG0840	transmembrane signaling receptor activity
GHV42_11720	COG0835	chemotaxis
GHV42_11730	COG0840	transmembrane signaling receptor activity
GHV42_11760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GHV42_11790	COG0318	PFAM AMP-dependent synthetase and ligase
GHV42_11795	COG1024	Enoyl-CoA hydratase
GHV42_11800	COG0784	Response regulator, receiver
GHV42_11800	COG2198	Histidine kinase
GHV42_11800	COG2205	protein histidine kinase activity
GHV42_11820	COG3279	Response regulator of the LytR AlgR family
GHV42_11835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GHV42_11845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GHV42_11850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GHV42_11860	COG0505	Belongs to the CarA family
GHV42_11865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GHV42_11870	COG2258	MOSC domain
GHV42_11875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GHV42_11925	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GHV42_11945	COG0277	FAD linked oxidase domain protein
GHV42_11950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GHV42_11960	COG0531	amino acid
GHV42_11965	COG0531	amino acid
GHV42_11970	COG0235	Class ii aldolase
GHV42_11995	COG0140	phosphoribosyl-ATP diphosphatase activity
GHV42_11995	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GHV42_12040	COG3039	Transposase
GHV42_12050	COG0124	histidyl-tRNA synthetase
GHV42_12070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GHV42_12125	COG1012	belongs to the aldehyde dehydrogenase family
GHV42_12145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GHV42_12150	COG0697	spore germination
GHV42_12155	COG1794	racemase activity, acting on amino acids and derivatives
GHV42_12170	COG0671	phosphoesterase, PA-phosphatase related
GHV42_12185	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GHV42_12195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GHV42_12205	COG5001	Diguanylate cyclase
GHV42_12205	COG4251	negative regulation of phosphorylation
GHV42_12205	COG3706	GGDEF domain
GHV42_12205	COG2203	Gaf domain
GHV42_12225	COG1472	Belongs to the glycosyl hydrolase 3 family
GHV42_12250	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GHV42_12270	COG0617	tRNA 3'-terminal CCA addition
GHV42_12285	COG0860	N-Acetylmuramoyl-L-alanine amidase
GHV42_12295	COG0477	Major facilitator Superfamily
GHV42_12305	COG1070	Carbohydrate kinase
GHV42_12330	COG0800	Aldolase
GHV42_12345	COG3734	2-keto-3-deoxy-galactonokinase
GHV42_12350	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GHV42_12360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GHV42_12375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GHV42_12380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GHV42_12390	COG0351	phosphomethylpyrimidine kinase
GHV42_12390	COG0352	thiamine-phosphate diphosphorylase activity
GHV42_12415	COG0583	DNA-binding transcription factor activity
GHV42_12420	COG1741	Belongs to the pirin family
GHV42_12470	COG0402	S-adenosylhomocysteine deaminase activity
GHV42_12485	COG1509	lysine 2,3-aminomutase activity
GHV42_12490	COG3300	MHYT domain
GHV42_12490	COG5001	Diguanylate cyclase
GHV42_12505	COG0483	inositol monophosphate 1-phosphatase activity
GHV42_12540	COG0513	Belongs to the DEAD box helicase family
GHV42_12550	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GHV42_12560	COG0625	glutathione transferase activity
GHV42_12575	COG4681	YaeQ
GHV42_12580	COG2081	HI0933 family
GHV42_12600	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_12625	COG0860	N-Acetylmuramoyl-L-alanine amidase
GHV42_12630	COG0802	atpase or kinase
GHV42_12635	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GHV42_12635	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GHV42_12640	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GHV42_12660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GHV42_12725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GHV42_12820	COG2801	Transposase and inactivated derivatives
GHV42_12835	COG0835	chemotaxis
GHV42_12840	COG0840	transmembrane signaling receptor activity
GHV42_12865	COG2969	positive regulation of protein catabolic process
GHV42_12870	COG0625	glutathione transferase activity
GHV42_12875	COG2857	Cytochrome c1
GHV42_12880	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GHV42_12885	COG0723	plastoquinol--plastocyanin reductase activity
GHV42_12890	COG0741	lytic transglycosylase activity
GHV42_12915	COG1702	phosphate starvation-inducible protein PhoH
GHV42_12935	COG4535	Mg2 and Co2 transporter CorC
GHV42_12950	COG1012	belongs to the aldehyde dehydrogenase family
GHV42_12955	COG1177	transmembrane transport
GHV42_12960	COG1176	ABC-type spermidine putrescine transport system, permease component I
GHV42_12970	COG3842	ATPase activity
GHV42_12990	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GHV42_13015	COG3501	Rhs element vgr protein
GHV42_13030	COG2201	protein-glutamate methylesterase activity
GHV42_13045	COG3501	Rhs element vgr protein
GHV42_13075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GHV42_13080	COG0174	glutamine synthetase
GHV42_13085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHV42_13090	COG3706	GGDEF domain
GHV42_13090	COG0745	RESPONSE REGULATOR receiver
GHV42_13095	COG0477	Major facilitator Superfamily
GHV42_13105	COG0243	molybdopterin cofactor binding
GHV42_13130	COG1121	(ABC) transporter
GHV42_13140	COG2733	membrane
GHV42_13145	COG0784	Response regulator, receiver
GHV42_13145	COG5002	protein histidine kinase activity
GHV42_13145	COG2205	protein histidine kinase activity
GHV42_13160	COG0477	Major facilitator Superfamily
GHV42_13170	COG2902	Dehydrogenase
GHV42_13180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHV42_13185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GHV42_13195	COG1609	Transcriptional regulator
GHV42_13200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GHV42_13200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GHV42_13205	COG1105	Belongs to the carbohydrate kinase PfkB family
GHV42_13210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GHV42_13210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GHV42_13220	COG2826	transposase and inactivated derivatives, IS30 family
GHV42_13225	COG3039	Transposase
GHV42_13265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GHV42_13275	COG1862	Preprotein translocase
GHV42_13340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GHV42_13355	COG0742	ribosomal rna small subunit methyltransferase
GHV42_13360	COG0326	Molecular chaperone. Has ATPase activity
GHV42_13390	COG3209	COG3209 Rhs family protein
GHV42_13445	COG4206	TonB-dependent receptor
GHV42_13495	COG0531	amino acid
GHV42_13510	COG0006	proline dipeptidase activity
GHV42_13520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GHV42_13535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHV42_13540	COG3938	Belongs to the proline racemase family
GHV42_13550	COG0552	protein localization to endoplasmic reticulum
GHV42_13560	COG1194	a g-specific adenine glycosylase
GHV42_13570	COG4191	Histidine kinase
GHV42_13570	COG0784	Response regulator, receiver
GHV42_13575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GHV42_13595	COG3040	lipid binding
GHV42_13605	COG1960	acyl-CoA dehydrogenase activity
GHV42_13655	COG0438	transferase activity, transferring glycosyl groups
GHV42_13660	COG0438	transferase activity, transferring glycosyl groups
GHV42_13705	COG0776	regulation of translation
GHV42_13715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GHV42_13720	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GHV42_13725	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GHV42_13730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GHV42_13765	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GHV42_13780	COG3115	cell septum assembly
GHV42_13805	COG0316	Belongs to the HesB IscA family
GHV42_13835	COG0288	reversible hydration of carbon dioxide
GHV42_13850	COG3844	kynureninase activity
GHV42_13860	COG2925	Exonuclease
GHV42_13870	COG0667	Aldo Keto reductase
GHV42_13885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GHV42_13940	COG0494	nUDIX hydrolase
GHV42_13950	COG1024	Enoyl-CoA hydratase
GHV42_13960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GHV42_13990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GHV42_13995	COG0573	inorganic phosphate transmembrane transporter activity
GHV42_14010	COG0704	Plays a role in the regulation of phosphate uptake
GHV42_14020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GHV42_14030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GHV42_14045	COG0557	exoribonuclease II activity
GHV42_14070	COG1960	acyl-CoA dehydrogenase activity
GHV42_14095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHV42_14135	COG0386	Belongs to the glutathione peroxidase family
GHV42_14145	COG1725	Transcriptional regulator
GHV42_14150	COG1131	(ABC) transporter
GHV42_14215	COG2850	peptidyl-arginine hydroxylation
GHV42_14250	COG1132	(ABC) transporter
GHV42_14260	COG0583	DNA-binding transcription factor activity
GHV42_14280	COG3039	Transposase
GHV42_14305	COG3039	Transposase
GHV42_14335	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GHV42_14345	COG0443	Heat shock 70 kDa protein
GHV42_14360	COG0497	DNA recombination
GHV42_14370	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GHV42_14375	COG2914	Belongs to the UPF0125 (RnfH) family
GHV42_14385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GHV42_14470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHV42_14475	COG2311	Membrane
GHV42_14480	COG1047	Peptidyl-prolyl cis-trans
GHV42_14485	COG0791	NLP P60 protein
GHV42_14490	COG0791	NLP P60 protein
GHV42_14505	COG4106	trans-aconitate 2-methyltransferase activity
GHV42_14510	COG1301	dicarboxylic acid transport
GHV42_14515	COG1785	Belongs to the alkaline phosphatase family
GHV42_14520	COG0037	tRNA processing
GHV42_14525	COG1722	exodeoxyribonuclease VII activity
GHV42_14530	COG0142	geranyltranstransferase activity
GHV42_14535	COG4104	PAAR repeat-containing protein
GHV42_14550	COG0312	modulator of DNA gyrase
GHV42_14555	COG3028	Belongs to the UPF0307 family
GHV42_14560	COG0312	modulator of DNA gyrase
GHV42_14570	COG3164	Protein of unknown function
GHV42_14575	COG1530	ribonuclease E activity
GHV42_14585	COG2968	Membrane
GHV42_14630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GHV42_14655	COG3118	belongs to the thioredoxin family
GHV42_14720	COG1132	(ABC) transporter
GHV42_14750	COG0745	RESPONSE REGULATOR receiver
GHV42_14755	COG5000	phosphorelay sensor kinase activity
GHV42_14755	COG5002	protein histidine kinase activity
GHV42_14760	COG0475	glutathione-regulated potassium exporter activity
GHV42_14765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GHV42_14790	COG1187	pseudouridine synthase activity
GHV42_14795	COG5002	protein histidine kinase activity
GHV42_14795	COG5001	Diguanylate cyclase
GHV42_14845	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GHV42_14930	COG0735	belongs to the Fur family
GHV42_14970	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GHV42_14995	COG2198	Histidine kinase
GHV42_14995	COG0643	Histidine kinase
GHV42_15000	COG0840	transmembrane signaling receptor activity
GHV42_15005	COG0835	chemotaxis
GHV42_15010	COG2199	diguanylate cyclase activity
GHV42_15010	COG2200	EAL domain
GHV42_15010	COG2202	Pas domain
GHV42_15015	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GHV42_15075	COG3501	Rhs element vgr protein
GHV42_15095	COG1515	deoxyribonuclease V activity
GHV42_15105	COG1741	Belongs to the pirin family
GHV42_15155	COG3501	Rhs element vgr protein
GHV42_15185	COG3501	Rhs element vgr protein
GHV42_15195	COG1741	Belongs to the pirin family
GHV42_15200	COG1966	Carbon starvation protein
GHV42_15205	COG2879	small protein
GHV42_15255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GHV42_15260	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GHV42_15265	COG2080	2 iron, 2 sulfur cluster binding
GHV42_15275	COG4251	negative regulation of phosphorylation
GHV42_15275	COG5001	Diguanylate cyclase
GHV42_15275	COG3706	GGDEF domain
GHV42_15275	COG2203	Gaf domain
GHV42_15280	COG0629	single-stranded DNA binding
GHV42_15285	COG0142	geranyltranstransferase activity
GHV42_15310	COG0527	aspartate kinase activity
GHV42_15320	COG0384	phenazine biosynthesis protein PhzF
GHV42_15330	COG1764	response to oxidative stress
GHV42_15340	COG0540	Belongs to the ATCase OTCase family
GHV42_15350	COG1678	Uncharacterized ACR, COG1678
GHV42_15360	COG0519	Catalyzes the synthesis of GMP from XMP
GHV42_15390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GHV42_15445	COG1959	2 iron, 2 sulfur cluster binding
GHV42_15450	COG0719	Fe-S assembly protein
GHV42_15455	COG0396	ATPase activity
GHV42_15460	COG0719	Fe-S assembly protein
GHV42_15465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GHV42_15495	COG1555	photosystem II stabilization
GHV42_15500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GHV42_15515	COG3178	'Phosphotransferase
GHV42_15520	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GHV42_15535	COG0628	permease
GHV42_15560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GHV42_15590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GHV42_15600	COG0271	Belongs to the BolA IbaG family
GHV42_15610	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GHV42_15620	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GHV42_15625	COG1137	ATPase activity
GHV42_15640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GHV42_15660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GHV42_15665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GHV42_15670	COG2239	Acts as a magnesium transporter
GHV42_15680	COG1294	oxidase, subunit
GHV42_15685	COG1271	oxidase subunit
GHV42_15695	COG1113	amino acid transport
GHV42_15710	COG2197	response regulator
GHV42_15715	COG0531	amino acid
GHV42_15765	COG0789	Transcriptional regulator
GHV42_15780	COG0754	glutathionylspermidine amidase activity
GHV42_15805	COG1842	Phage shock protein A
GHV42_15890	COG3501	Rhs element vgr protein
GHV42_15960	COG3179	chitinase
GHV42_15970	COG3039	Transposase
GHV42_15980	COG3501	Rhs element vgr protein
GHV42_16015	COG3039	Transposase
GHV42_16035	COG3501	Rhs element vgr protein
GHV42_16075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GHV42_16085	COG3501	Rhs element vgr protein
GHV42_16115	COG3501	Rhs element vgr protein
GHV42_16135	COG3501	Rhs element vgr protein
GHV42_16195	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GHV42_16220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GHV42_16235	COG2197	response regulator
GHV42_16240	COG4585	Histidine kinase
GHV42_16255	COG2894	cell division
GHV42_16260	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GHV42_16270	COG0642	Histidine kinase
GHV42_16275	COG0745	RESPONSE REGULATOR receiver
GHV42_16280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GHV42_16290	COG2194	sulfuric ester hydrolase activity
GHV42_16320	COG3551	Protein conserved in bacteria
GHV42_16355	COG0753	catalase activity
GHV42_16385	COG2207	Transcriptional regulator
GHV42_16385	COG1917	Cupin 2, conserved barrel domain protein
GHV42_16400	COG1506	peptidase
GHV42_16400	COG0823	Involved in the tonB-independent uptake of proteins
GHV42_16415	COG1297	OPT oligopeptide transporter protein
GHV42_16430	COG0587	DNA-directed DNA polymerase activity
GHV42_16470	COG0406	alpha-ribazole phosphatase activity
GHV42_16470	COG0328	RNA-DNA hybrid ribonuclease activity
GHV42_16500	COG0732	type I restriction modification DNA specificity domain
GHV42_16535	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GHV42_16545	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GHV42_16550	COG0732	type I restriction modification DNA specificity domain
GHV42_16580	COG3501	Rhs element vgr protein
GHV42_16595	COG0308	aminopeptidase N
GHV42_16610	COG0330	HflC and HflK could
GHV42_16615	COG0330	HflC and HflK could
GHV42_16635	COG0678	peroxiredoxin activity
GHV42_16685	COG2826	transposase and inactivated derivatives, IS30 family
GHV42_16695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GHV42_16710	COG3829	transcription factor binding
GHV42_16720	COG3039	Transposase
GHV42_16745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GHV42_16750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GHV42_16765	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_16790	COG1399	metal-binding, possibly nucleic acid-binding protein
GHV42_16810	COG0714	Associated with various cellular activities
GHV42_16830	COG0537	adenosine 5'-monophosphoramidase activity
GHV42_16840	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GHV42_16860	COG0314	molybdopterin synthase activity
GHV42_16865	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GHV42_16880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GHV42_16885	COG1234	tRNA 3'-trailer cleavage
GHV42_16895	COG0859	PFAM glycosyl transferase family 9
GHV42_16910	COG0631	protein serine/threonine phosphatase activity
GHV42_16915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GHV42_16940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GHV42_16975	COG0740	serine-type endopeptidase activity
GHV42_16980	COG0544	peptidyl-prolyl cis-trans isomerase activity
GHV42_17025	COG0473	3-isopropylmalate dehydrogenase activity
GHV42_17040	COG4783	chaperone-mediated protein folding
GHV42_17055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GHV42_17065	COG0438	transferase activity, transferring glycosyl groups
GHV42_17070	COG0671	phosphoesterase, PA-phosphatase related
GHV42_17085	COG3291	Pkd domain containing protein
GHV42_17085	COG3291	Pkd domain containing protein
GHV42_17095	COG2833	Protein of unknown function (DUF455)
GHV42_17115	COG0285	dihydrofolate synthase activity
GHV42_17120	COG0406	alpha-ribazole phosphatase activity
GHV42_17145	COG1063	alcohol dehydrogenase
GHV42_17155	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GHV42_17160	COG4208	sulfate ABC transporter
GHV42_17165	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GHV42_17170	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GHV42_17175	COG0156	8-amino-7-oxononanoate synthase activity
GHV42_17200	COG0604	alcohol dehydrogenase
GHV42_17205	COG0446	pyridine nucleotide-disulphide oxidoreductase
GHV42_17205	COG1902	pentaerythritol trinitrate reductase activity
GHV42_17235	COG0584	glycerophosphoryl diester phosphodiesterase
GHV42_17265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GHV42_17290	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GHV42_17305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GHV42_17310	COG0203	ribosomal protein L17
GHV42_17315	COG0202	RNA polymerase activity
GHV42_17330	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GHV42_17335	COG0201	protein transport
GHV42_17340	COG0200	Binds to the 23S rRNA
GHV42_17345	COG1841	ribosomal large subunit assembly
GHV42_17350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GHV42_17370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GHV42_17380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GHV42_17390	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GHV42_17395	COG0255	Belongs to the universal ribosomal protein uL29 family
GHV42_17400	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GHV42_17420	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GHV42_17425	COG0089	rRNA binding
GHV42_17465	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GHV42_17485	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GHV42_17490	COG0081	regulation of translation
GHV42_17500	COG0250	Participates in transcription elongation, termination and antitermination
GHV42_17505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GHV42_17535	COG0012	GTP binding
GHV42_17550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GHV42_17575	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GHV42_17590	COG0521	Mo-molybdopterin cofactor biosynthetic process
GHV42_17610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GHV42_17650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GHV42_17660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GHV42_17685	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GHV42_17690	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GHV42_17715	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GHV42_17760	COG2890	protein-(glutamine-N5) methyltransferase activity
GHV42_17770	COG3634	alkyl hydroperoxide reductase activity
GHV42_17775	COG0583	DNA-binding transcription factor activity
GHV42_17785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GHV42_17790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GHV42_17800	COG2197	response regulator
GHV42_17805	COG3706	GGDEF domain
GHV42_17805	COG0745	RESPONSE REGULATOR receiver
GHV42_17825	COG0697	spore germination
GHV42_17855	COG3386	PFAM SMP-30 Gluconolaconase
GHV42_17865	COG3039	Transposase
GHV42_17880	COG1024	Enoyl-CoA hydratase
GHV42_17890	COG0318	PFAM AMP-dependent synthetase and ligase
GHV42_17895	COG0583	DNA-binding transcription factor activity
GHV42_17900	COG3384	dioxygenase
GHV42_17930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GHV42_17935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GHV42_17945	COG2096	Adenosyltransferase
GHV42_17950	COG0123	including yeast histone deacetylase and acetoin utilization protein
GHV42_17965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GHV42_17985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GHV42_18025	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GHV42_18040	COG0642	Histidine kinase
GHV42_18055	COG4181	ATPase activity
GHV42_18065	COG2175	clavaminate synthase activity
GHV42_18080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GHV42_18100	COG0667	Aldo Keto reductase
GHV42_18110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GHV42_18115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHV42_18125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GHV42_18140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GHV42_18185	COG2226	methyltransferase
GHV42_18235	COG0604	alcohol dehydrogenase
GHV42_18235	COG3321	synthase
GHV42_18235	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_18245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GHV42_18260	COG0494	nUDIX hydrolase
GHV42_18275	COG1388	LysM domain
GHV42_18275	COG4942	peptidase
GHV42_18305	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GHV42_18310	COG1181	Belongs to the D-alanine--D-alanine ligase family
GHV42_18330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GHV42_18335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GHV42_18350	COG3116	cell division
GHV42_18400	COG1988	membrane-bound metal-dependent
GHV42_18405	COG0277	FAD linked oxidase domain protein
GHV42_18410	COG0745	RESPONSE REGULATOR receiver
GHV42_18415	COG2205	protein histidine kinase activity
GHV42_18425	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GHV42_18430	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GHV42_18450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GHV42_18480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GHV42_18480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GHV42_18495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GHV42_18525	COG0488	(ABC) transporter
GHV42_18570	COG0745	RESPONSE REGULATOR receiver
GHV42_18575	COG2205	protein histidine kinase activity
GHV42_18675	COG1649	PFAM Uncharacterised BCR, COG1649
GHV42_18675	COG0726	polysaccharide deacetylase
GHV42_18680	COG1215	transferase activity, transferring glycosyl groups
GHV42_18690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GHV42_18695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GHV42_18700	COG1609	Transcriptional regulator
GHV42_18725	COG3250	beta-galactosidase activity
GHV42_18760	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GHV42_18765	COG4191	Histidine kinase
GHV42_18770	COG0784	Response regulator, receiver
GHV42_18775	COG4251	negative regulation of phosphorylation
GHV42_18780	COG2823	Periplasmic or secreted lipoprotein
GHV42_18785	COG0673	inositol 2-dehydrogenase activity
GHV42_18790	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GHV42_18825	COG1051	belongs to the nudix hydrolase family
GHV42_18825	COG1056	cytidyltransferase-related domain
GHV42_18860	COG1686	Belongs to the peptidase S11 family
GHV42_18865	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GHV42_18870	COG2951	lytic endotransglycosylase activity
GHV42_18905	COG3501	Rhs element vgr protein
GHV42_18930	COG0772	Belongs to the SEDS family
GHV42_18945	COG1792	Involved in formation and maintenance of cell shape
GHV42_18950	COG1077	Cell shape determining protein MreB Mrl
GHV42_18975	COG5001	Diguanylate cyclase
GHV42_18975	COG3300	MHYT domain
GHV42_19020	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GHV42_19040	COG2832	Protein of unknown function (DUF454)
GHV42_19065	COG1505	serine-type exopeptidase activity
GHV42_19100	COG3275	phosphorelay sensor kinase activity
GHV42_19130	COG0659	secondary active sulfate transmembrane transporter activity
GHV42_19210	COG0598	Magnesium transport protein CorA
GHV42_19220	COG1113	amino acid transport
GHV42_19240	COG4305	rare lipoprotein A
GHV42_19245	COG0697	spore germination
GHV42_19295	COG4221	oxidoreductase activity
GHV42_19335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GHV42_19360	COG0459	protein refolding
GHV42_19365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GHV42_19390	COG2860	membrane
GHV42_19395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GHV42_19405	COG3437	response regulator, receiver
GHV42_19410	COG2177	Part of the ABC transporter FtsEX involved in
GHV42_19415	COG2884	Cell division ATP-binding protein ftsE
GHV42_19425	COG3118	belongs to the thioredoxin family
GHV42_19430	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GHV42_19480	COG1473	amidohydrolase
GHV42_19485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHV42_19490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GHV42_19520	COG5383	Protein conserved in bacteria
GHV42_19570	COG3023	N-Acetylmuramoyl-L-alanine amidase
GHV42_19580	COG4948	Mandelate Racemase Muconate Lactonizing
GHV42_19595	COG0531	amino acid
GHV42_19615	COG4682	membrane
GHV42_19620	COG2133	pyrroloquinoline quinone binding
GHV42_19640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GHV42_19650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GHV42_19655	COG1610	YqeY-like protein
GHV42_19670	COG1295	ribonuclease BN
GHV42_19675	COG0358	DNA primase activity
GHV42_19730	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GHV42_19745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GHV42_19800	COG0739	heme binding
GHV42_19815	COG2211	Major facilitator Superfamily
GHV42_19820	COG0708	Exodeoxyribonuclease III
GHV42_19865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GHV42_19865	COG2111	Na H antiporter
GHV42_19870	COG1006	Multisubunit Na H antiporter MnhC subunit
GHV42_19875	COG0651	ATP synthesis coupled electron transport
GHV42_19885	COG2212	antiporter activity
GHV42_19890	COG1320	monovalent cation:proton antiporter activity
GHV42_19925	COG3104	oligopeptide transport
GHV42_19940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GHV42_19955	COG0508	dehydrogenase complex catalyzes the overall conversion of
GHV42_19970	COG3039	Transposase
GHV42_19975	COG0513	Belongs to the DEAD box helicase family
GHV42_20045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GHV42_20050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GHV42_20060	COG0045	succinate-CoA ligase (ADP-forming) activity
GHV42_20060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GHV42_20060	COG1042	CoA-binding domain protein
GHV42_20070	COG2239	Acts as a magnesium transporter
GHV42_20100	COG3039	Transposase
GHV42_20105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GHV42_20125	COG3100	YcgL domain-containing protein
GHV42_20130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GHV42_20140	COG0463	Glycosyl transferase, family 2
GHV42_20160	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_20200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GHV42_20215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GHV42_20330	COG0210	DNA helicase
GHV42_20345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GHV42_20350	COG0583	DNA-binding transcription factor activity
GHV42_20355	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GHV42_20365	COG2159	amidohydrolase
GHV42_20370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GHV42_20375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GHV42_20390	COG0357	Ribosomal RNA small subunit methyltransferase G
GHV42_20395	COG3540	Alkaline phosphatase
GHV42_20405	COG2091	lysine biosynthetic process via aminoadipic acid
GHV42_20420	COG0708	Exodeoxyribonuclease III
GHV42_20435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GHV42_20440	COG3162	membrane
GHV42_20480	COG1414	Transcriptional regulator
GHV42_20490	COG2205	protein histidine kinase activity
GHV42_20500	COG3459	Glycosyltransferase 36 associated
GHV42_20510	COG3265	gluconokinase activity
GHV42_20515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GHV42_20520	COG3039	Transposase
GHV42_20535	COG0339	signal peptide processing
GHV42_20565	COG0564	pseudouridine synthase activity
GHV42_20590	COG1181	Belongs to the D-alanine--D-alanine ligase family
GHV42_20600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GHV42_20605	COG0318	PFAM AMP-dependent synthetase and ligase
GHV42_20615	COG0596	Alpha beta hydrolase
GHV42_20620	COG3177	Filamentation induced by cAMP protein fic
GHV42_20625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GHV42_20640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GHV42_20665	COG2205	protein histidine kinase activity
GHV42_20670	COG0028	Belongs to the TPP enzyme family
GHV42_20685	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GHV42_20690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GHV42_20735	COG0183	Belongs to the thiolase family
GHV42_20760	COG3039	Transposase
GHV42_20785	COG2032	superoxide dismutase activity
GHV42_20790	COG2032	superoxide dismutase activity
GHV42_20795	COG2204	response regulator
GHV42_20800	COG3852	Histidine kinase
GHV42_20805	COG0004	ammonium transporteR
GHV42_20810	COG0347	Belongs to the P(II) protein family
GHV42_20815	COG0174	glutamine synthetase
GHV42_20865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GHV42_20875	COG2062	phosphohistidine phosphatase, SixA
GHV42_20880	COG0489	protein tyrosine kinase activity
GHV42_20900	COG1396	sequence-specific DNA binding
GHV42_20905	COG3550	peptidyl-serine autophosphorylation
GHV42_20910	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GHV42_20915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GHV42_20930	COG1125	glycine betaine transport
GHV42_20930	COG0517	IMP dehydrogenase activity
GHV42_20945	COG1119	ATPase activity
GHV42_20955	COG1473	amidohydrolase
GHV42_20960	COG1752	Esterase of the alpha-beta hydrolase superfamily
GHV42_20970	COG1522	sequence-specific DNA binding
GHV42_20975	COG3186	Phenylalanine-4-hydroxylase
GHV42_20995	COG1609	Transcriptional regulator
GHV42_21020	COG0366	Alpha amylase catalytic
GHV42_21025	COG0366	Alpha amylase catalytic
GHV42_21040	COG3039	Transposase
GHV42_21075	COG3135	benzoate transporter
GHV42_21095	COG0676	glucose-6-phosphate 1-epimerase activity
GHV42_21150	COG0302	gtp cyclohydrolase
GHV42_21180	COG0477	Major facilitator Superfamily
GHV42_21275	COG3237	CsbD-like
GHV42_21360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHV42_21385	COG3039	Transposase
GHV42_21405	COG1755	Isoprenylcysteine carboxyl methyltransferase
GHV42_21415	COG3039	Transposase
GHV42_21425	COG4772	TonB-dependent receptor
GHV42_21435	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GHV42_21460	COG1272	protein, Hemolysin III
GHV42_21465	COG1111	helicase
GHV42_21465	COG1205	dead DEAH box helicase
GHV42_21525	COG0070	glutamate synthase
GHV42_21525	COG0069	glutamate synthase activity
GHV42_21525	COG0067	glutamate synthase
GHV42_21530	COG0493	'glutamate synthase
GHV42_21540	COG0531	amino acid
GHV42_21550	COG1322	Protein conserved in bacteria
GHV42_21560	COG0386	Belongs to the glutathione peroxidase family
GHV42_21565	COG2853	Lipoprotein
GHV42_21580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GHV42_21585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GHV42_21590	COG1127	ABC transporter
GHV42_21625	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GHV42_21630	COG1074	ATP-dependent DNA helicase activity
GHV42_21635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GHV42_21725	COG2124	cytochrome p450
GHV42_21730	COG2124	cytochrome p450
GHV42_21735	COG1141	Ferredoxin
GHV42_21740	COG1028	Short-chain dehydrogenase reductase Sdr
GHV42_21745	COG2124	cytochrome p450
GHV42_21750	COG0142	geranyltranstransferase activity
GHV42_21755	COG1657	PFAM Prenyltransferase squalene oxidase
GHV42_21765	COG1304	FMN binding
GHV42_21780	COG0564	pseudouridine synthase activity
GHV42_21810	COG3706	GGDEF domain
GHV42_21820	COG1929	Belongs to the glycerate kinase type-1 family
GHV42_21825	COG2271	Major facilitator Superfamily
GHV42_21845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GHV42_21850	COG0861	Integral membrane protein TerC family
GHV42_21860	COG0584	glycerophosphoryl diester phosphodiesterase
GHV42_21870	COG0671	phosphoesterase, PA-phosphatase related
GHV42_21875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GHV42_21880	COG0726	polysaccharide deacetylase
GHV42_21895	COG0230	Belongs to the bacterial ribosomal protein bL34 family