locus-tag	class	description
K2I41_00065	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
K2I41_00070	COG2948	multi-organism process
K2I41_00075	COG3504	Conjugal transfer protein
K2I41_00210	COG0653	protein targeting
K2I41_00220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K2I41_00295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K2I41_00310	COG0187	DNA topoisomerase II activity
K2I41_00320	COG0501	Belongs to the peptidase M48B family
K2I41_00350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K2I41_00360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K2I41_00380	COG1064	alcohol dehydrogenase
K2I41_00385	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K2I41_00390	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K2I41_00405	COG3039	Transposase
K2I41_00410	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K2I41_00420	COG2234	aminopeptidase activity
K2I41_00430	COG4942	peptidase
K2I41_00435	COG0793	Belongs to the peptidase S41A family
K2I41_00480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K2I41_00500	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K2I41_00515	COG0210	DNA helicase
K2I41_00535	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
K2I41_00540	COG0284	orotidine-5'-phosphate decarboxylase activity
K2I41_00570	COG2937	Belongs to the GPAT DAPAT family
K2I41_00575	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_00575	COG3321	synthase
K2I41_00575	COG0604	alcohol dehydrogenase
K2I41_00620	COG2211	Major facilitator Superfamily
K2I41_00640	COG3693	PFAM glycoside hydrolase, family 10
K2I41_00670	COG4770	biotin carboxylase activity
K2I41_00675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K2I41_00680	COG1960	acyl-CoA dehydrogenase activity
K2I41_00730	COG0523	cobalamin synthesis protein
K2I41_00755	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K2I41_00760	COG1846	Transcriptional regulator
K2I41_00765	COG1764	response to oxidative stress
K2I41_00795	COG0656	L-ascorbic acid biosynthetic process
K2I41_00800	COG2130	NADP-dependent
K2I41_00805	COG0667	Aldo Keto reductase
K2I41_00815	COG1187	pseudouridine synthase activity
K2I41_00825	COG1643	Atp-dependent helicase
K2I41_00835	COG4807	Protein conserved in bacteria
K2I41_00840	COG2072	flavoprotein involved in K transport
K2I41_00860	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K2I41_00885	COG0129	dihydroxy-acid dehydratase activity
K2I41_00895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K2I41_00965	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K2I41_00970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K2I41_00980	COG3485	protocatechuate 3,4-dioxygenase
K2I41_00985	COG3485	protocatechuate 3,4-dioxygenase
K2I41_01000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K2I41_01005	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K2I41_01020	COG1414	Transcriptional regulator
K2I41_01030	COG0657	acetylesterase activity
K2I41_01100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K2I41_01140	COG0156	8-amino-7-oxononanoate synthase activity
K2I41_01145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K2I41_01150	COG1040	competence protein
K2I41_01155	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K2I41_01180	COG2911	Protein conserved in bacteria
K2I41_01185	COG0729	surface antigen
K2I41_01190	COG4771	TonB-dependent receptor
K2I41_01200	COG0457	Tetratricopeptide repeat
K2I41_01210	COG0752	glycyl-tRNA synthetase alpha subunit
K2I41_01215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K2I41_01225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K2I41_01225	COG0519	Catalyzes the synthesis of GMP from XMP
K2I41_01235	COG0805	protein transport
K2I41_01240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K2I41_01245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K2I41_01255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K2I41_01265	COG3039	Transposase
K2I41_01280	COG2974	May be involved in recombination
K2I41_01300	COG3661	Belongs to the glycosyl hydrolase 67 family
K2I41_01310	COG4948	Mandelate Racemase Muconate Lactonizing
K2I41_01320	COG1472	Belongs to the glycosyl hydrolase 3 family
K2I41_01325	COG0246	Mannitol dehydrogenase
K2I41_01420	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K2I41_01495	COG1511	domain protein
K2I41_01495	COG3264	Mechanosensitive ion channel
K2I41_01505	COG3039	Transposase
K2I41_01515	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K2I41_01520	COG2354	Protein conserved in bacteria
K2I41_01525	COG1649	PFAM Uncharacterised BCR, COG1649
K2I41_01545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K2I41_01570	COG0702	epimerase
K2I41_01585	COG1858	cytochrome C peroxidase
K2I41_01605	COG3209	COG3209 Rhs family protein
K2I41_01745	COG0084	hydrolase, TatD family'
K2I41_01765	COG2814	Major facilitator Superfamily
K2I41_01775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K2I41_01780	COG1902	pentaerythritol trinitrate reductase activity
K2I41_01810	COG0745	RESPONSE REGULATOR receiver
K2I41_01830	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K2I41_01835	COG0583	DNA-binding transcription factor activity
K2I41_01860	COG1733	regulation of RNA biosynthetic process
K2I41_01865	COG0702	epimerase
K2I41_01905	COG0583	DNA-binding transcription factor activity
K2I41_01945	COG1199	ATP-dependent helicase activity
K2I41_01975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K2I41_02005	COG3228	Belongs to the MtfA family
K2I41_02015	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K2I41_02015	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K2I41_02020	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K2I41_02035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K2I41_02065	COG3237	CsbD-like
K2I41_02070	COG0180	Tryptophanyl-tRNA synthetase
K2I41_02075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K2I41_02120	COG0753	catalase activity
K2I41_02135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K2I41_02170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K2I41_02180	COG0642	Histidine kinase
K2I41_02190	COG1090	epimerase
K2I41_02235	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K2I41_02255	COG0606	chelatase, subunit chli
K2I41_02340	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K2I41_02345	COG1166	arginine decarboxylase activity
K2I41_02360	COG2755	lipolytic protein G-D-S-L family
K2I41_02360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K2I41_02365	COG4221	oxidoreductase activity
K2I41_02390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K2I41_02415	COG0463	Glycosyl transferase, family 2
K2I41_02430	COG1475	DNA binding
K2I41_02435	COG1192	Involved in chromosome partitioning
K2I41_02465	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K2I41_02475	COG0456	acetyltransferase
K2I41_02510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K2I41_02515	COG0134	indole-3-glycerol-phosphate synthase activity
K2I41_02525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K2I41_02530	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K2I41_02540	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
K2I41_02550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K2I41_02620	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K2I41_02635	COG2814	Major facilitator Superfamily
K2I41_02650	COG1289	transmembrane transporter activity
K2I41_02660	COG0577	efflux transmembrane transporter activity
K2I41_02660	COG1136	(ABC) transporter
K2I41_02665	COG0151	Belongs to the GarS family
K2I41_02670	COG0138	bifunctional purine biosynthesis protein purh
K2I41_02700	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K2I41_02740	COG0439	Biotin carboxylase
K2I41_02750	COG0511	ligase activity, forming carbon-carbon bonds
K2I41_02755	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K2I41_02765	COG1324	tolerance protein
K2I41_02770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K2I41_02790	COG0534	Mate efflux family protein
K2I41_02795	COG0616	signal peptide processing
K2I41_02805	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_02820	COG0009	L-threonylcarbamoyladenylate synthase
K2I41_02825	COG1754	DNA topoisomerase type I activity
K2I41_02825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K2I41_02845	COG0758	DNA mediated transformation
K2I41_02850	COG1652	LysM domain
K2I41_02855	COG0242	peptide deformylase activity
K2I41_02860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K2I41_02865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K2I41_02865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K2I41_02915	COG1560	Kdo2-lipid A biosynthetic process
K2I41_02925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K2I41_02965	COG0625	glutathione transferase activity
K2I41_03000	COG4555	ABC transporter
K2I41_03010	COG1476	TRANSCRIPTIONal
K2I41_03035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K2I41_03040	COG1131	(ABC) transporter
K2I41_03045	COG0842	Transport permease protein
K2I41_03055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K2I41_03075	COG3039	Transposase
K2I41_03085	COG2951	lytic endotransglycosylase activity
K2I41_03095	COG3039	Transposase
K2I41_03125	COG2831	hemolysin activation secretion protein
K2I41_03230	COG2353	YceI-like domain
K2I41_03260	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K2I41_03360	COG1063	alcohol dehydrogenase
K2I41_03390	COG1294	oxidase, subunit
K2I41_03395	COG1271	oxidase subunit
K2I41_03430	COG2972	Histidine kinase
K2I41_03445	COG0531	amino acid
K2I41_03465	COG3590	peptidase
K2I41_03475	COG0667	Aldo Keto reductase
K2I41_03490	COG3384	dioxygenase
K2I41_03500	COG1573	uracil-dna glycosylase
K2I41_03510	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K2I41_03515	COG0025	NhaP-type Na H and K H
K2I41_03520	COG1131	(ABC) transporter
K2I41_03525	COG0842	Transport permease protein
K2I41_03540	COG1404	Belongs to the peptidase S8 family
K2I41_03555	COG0745	RESPONSE REGULATOR receiver
K2I41_03605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2I41_03630	COG2202	Pas domain
K2I41_03630	COG2205	protein histidine kinase activity
K2I41_03660	COG2813	Specifically methylates the guanine in position
K2I41_03665	COG1187	pseudouridine synthase activity
K2I41_03670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K2I41_03705	COG0697	spore germination
K2I41_03715	COG2011	ABC-type metal ion transport system permease component
K2I41_03750	COG0508	dehydrogenase complex catalyzes the overall conversion of
K2I41_03760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K2I41_03780	COG0356	it plays a direct role in the translocation of protons across the membrane
K2I41_03790	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K2I41_03800	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K2I41_03805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K2I41_03810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K2I41_03835	COG4191	Histidine kinase
K2I41_03845	COG1136	(ABC) transporter
K2I41_03845	COG0577	efflux transmembrane transporter activity
K2I41_03850	COG0577	efflux transmembrane transporter activity
K2I41_03850	COG1136	(ABC) transporter
K2I41_03865	COG1136	(ABC) transporter
K2I41_03870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K2I41_03875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K2I41_03930	COG0339	signal peptide processing
K2I41_03955	COG0546	phosphoglycolate phosphatase activity
K2I41_03965	COG1956	GAF domain-containing protein
K2I41_03970	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K2I41_03980	COG0720	synthase
K2I41_03985	COG0513	Belongs to the DEAD box helicase family
K2I41_03995	COG0625	glutathione transferase activity
K2I41_04025	COG0626	cystathionine gamma-synthase activity
K2I41_04040	COG0110	maltose O-acetyltransferase activity
K2I41_04045	COG1216	Glycosyl transferase, family 2
K2I41_04045	COG0438	transferase activity, transferring glycosyl groups
K2I41_04050	COG3754	Rhamnan synthesis protein F
K2I41_04080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K2I41_04095	COG0277	FAD linked oxidase domain protein
K2I41_04100	COG0546	phosphoglycolate phosphatase activity
K2I41_04100	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K2I41_04115	COG2086	electron transfer activity
K2I41_04140	COG0662	Cupin 2, conserved barrel domain protein
K2I41_04140	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K2I41_04145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K2I41_04185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K2I41_04185	COG3218	ABC-type transport auxiliary lipoprotein component
K2I41_04190	COG1127	ABC transporter
K2I41_04195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K2I41_04210	COG0442	prolyl-tRNA aminoacylation
K2I41_04220	COG1183	phosphatidylcholine synthase activity
K2I41_04250	COG0525	valine-tRNA ligase activity
K2I41_04265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K2I41_04275	COG0795	lipopolysaccharide-transporting ATPase activity
K2I41_04290	COG4974	Belongs to the 'phage' integrase family
K2I41_04295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K2I41_04300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K2I41_04300	COG0047	phosphoribosylformylglycinamidine synthase activity
K2I41_04305	COG5295	Hep Hag repeat protein
K2I41_04310	COG1404	Belongs to the peptidase S8 family
K2I41_04315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K2I41_04325	COG1459	type II secretion system
K2I41_04330	COG2165	general secretion pathway protein
K2I41_04335	COG4970	Tfp pilus assembly protein FimT
K2I41_04340	COG2165	general secretion pathway protein
K2I41_04345	COG4795	General secretion pathway protein
K2I41_04350	COG3156	type II secretion system protein K
K2I41_04355	COG3166	PFAM Fimbrial assembly family protein
K2I41_04370	COG1450	Type ii and iii secretion system protein
K2I41_04385	COG2188	Transcriptional regulator
K2I41_04435	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K2I41_04465	COG0242	peptide deformylase activity
K2I41_04505	COG1228	amidohydrolase
K2I41_04510	COG3964	amidohydrolase
K2I41_04530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K2I41_04535	COG0726	polysaccharide deacetylase
K2I41_04555	COG0436	Aminotransferase
K2I41_04585	COG2211	Major facilitator Superfamily
K2I41_04595	COG1609	Transcriptional regulator
K2I41_04600	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_04605	COG2851	Citrate transporter
K2I41_04620	COG0642	Histidine kinase
K2I41_04630	COG2197	response regulator
K2I41_04645	COG0583	DNA-binding transcription factor activity
K2I41_04660	COG4191	Histidine kinase
K2I41_04680	COG0280	phosphate acetyltransferase
K2I41_04680	COG0281	malic enzyme
K2I41_04705	COG1560	Kdo2-lipid A biosynthetic process
K2I41_04710	COG1519	Transferase
K2I41_04715	COG1538	Outer membrane efflux protein
K2I41_04720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K2I41_04740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K2I41_04745	COG0066	3-isopropylmalate dehydratase activity
K2I41_04750	COG2226	methyltransferase
K2I41_04780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K2I41_04790	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K2I41_04795	COG3710	Transcriptional regulator
K2I41_04820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K2I41_04830	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K2I41_04860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K2I41_04870	COG3781	membrane
K2I41_04890	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_04910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K2I41_04915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K2I41_04970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K2I41_04980	COG0352	thiamine-phosphate diphosphorylase activity
K2I41_04985	COG1773	rubredoxin
K2I41_04990	COG2912	Transglutaminase-like superfamily
K2I41_05010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K2I41_05035	COG0006	proline dipeptidase activity
K2I41_05070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K2I41_05080	COG0346	lactoylglutathione lyase activity
K2I41_05085	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K2I41_05090	COG1561	YicC-like family, N-terminal region
K2I41_05110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K2I41_05120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K2I41_05150	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K2I41_05185	COG0714	Associated with various cellular activities
K2I41_05205	COG2304	oxidoreductase activity
K2I41_05240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K2I41_05350	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K2I41_05355	COG4149	molybdate abc transporter
K2I41_05360	COG0725	ABC transporter, periplasmic molybdate-binding protein
K2I41_05365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K2I41_05365	COG3453	Protein conserved in bacteria
K2I41_05375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K2I41_05390	COG0126	phosphoglycerate kinase activity
K2I41_05400	COG0469	pyruvate kinase activity
K2I41_05405	COG3588	fructose-bisphosphate aldolase
K2I41_05410	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K2I41_05450	COG2198	Histidine kinase
K2I41_05450	COG2205	protein histidine kinase activity
K2I41_05450	COG0784	Response regulator, receiver
K2I41_05470	COG0175	sulfate reduction
K2I41_05475	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K2I41_05480	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K2I41_05485	COG0175	sulfate reduction
K2I41_05490	COG2895	sulfate adenylyltransferase (ATP) activity
K2I41_05490	COG0529	Catalyzes the synthesis of activated sulfate
K2I41_05500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K2I41_05505	COG0308	aminopeptidase N
K2I41_05530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K2I41_05555	COG1970	mechanosensitive ion channel activity
K2I41_05580	COG0471	metal ion transport
K2I41_05580	COG3273	potassium ion transport
K2I41_05590	COG2022	thiamine diphosphate biosynthetic process
K2I41_05610	COG3039	Transposase
K2I41_05665	COG0745	RESPONSE REGULATOR receiver
K2I41_05700	COG2826	transposase and inactivated derivatives, IS30 family
K2I41_05730	COG3039	Transposase
K2I41_05740	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K2I41_05750	COG4969	Belongs to the N-Me-Phe pilin family
K2I41_05755	COG2194	sulfuric ester hydrolase activity
K2I41_05795	COG0045	succinate-CoA ligase (ADP-forming) activity
K2I41_05800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K2I41_05815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K2I41_05815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K2I41_05820	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K2I41_05825	COG0564	pseudouridine synthase activity
K2I41_05840	COG3011	Protein conserved in bacteria
K2I41_05845	COG0840	transmembrane signaling receptor activity
K2I41_05860	COG3387	PFAM Glycoside hydrolase 15-related
K2I41_05865	COG1877	trehalose-phosphatase activity
K2I41_05905	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K2I41_05920	COG1595	DNA-templated transcription, initiation
K2I41_05930	COG1946	Acyl-CoA thioesterase
K2I41_05945	COG0824	Thioesterase
K2I41_05950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K2I41_05960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K2I41_05965	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K2I41_05970	COG0268	Binds directly to 16S ribosomal RNA
K2I41_05975	COG0728	peptidoglycan biosynthetic process
K2I41_05980	COG0196	riboflavin kinase activity
K2I41_05990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K2I41_05995	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K2I41_06010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K2I41_06015	COG1845	cytochrome c oxidase, subunit III
K2I41_06020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K2I41_06105	COG2207	Transcriptional regulator
K2I41_06110	COG0326	Molecular chaperone. Has ATPase activity
K2I41_06120	COG1366	Belongs to the anti-sigma-factor antagonist family
K2I41_06125	COG1366	Belongs to the anti-sigma-factor antagonist family
K2I41_06130	COG2172	sigma factor antagonist activity
K2I41_06170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K2I41_06175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K2I41_06190	COG2070	2-Nitropropane dioxygenase
K2I41_06200	COG0228	four-way junction DNA binding
K2I41_06205	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K2I41_06210	COG0336	Belongs to the RNA methyltransferase TrmD family
K2I41_06225	COG0534	Mate efflux family protein
K2I41_06235	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K2I41_06260	COG0542	response to heat
K2I41_06270	COG3039	Transposase
K2I41_06315	COG0019	diaminopimelate decarboxylase activity
K2I41_06330	COG4264	IucA IucC family
K2I41_06340	COG4772	TonB-dependent receptor
K2I41_06355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K2I41_06355	COG4651	solute:proton antiporter activity
K2I41_06385	COG0488	(ABC) transporter
K2I41_06425	COG0477	Major facilitator Superfamily
K2I41_06440	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K2I41_06475	COG2255	four-way junction helicase activity
K2I41_06480	COG0824	Thioesterase
K2I41_06500	COG0823	Involved in the tonB-independent uptake of proteins
K2I41_06505	COG2885	chlorophyll binding
K2I41_06515	COG0602	queuosine metabolic process
K2I41_06525	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K2I41_06565	COG1187	pseudouridine synthase activity
K2I41_06580	COG0514	ATP-dependent DNA helicase (RecQ)
K2I41_06585	COG0783	Belongs to the Dps family
K2I41_06590	COG1643	Atp-dependent helicase
K2I41_06650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K2I41_06660	COG1215	transferase activity, transferring glycosyl groups
K2I41_06665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K2I41_06675	COG1199	ATP-dependent helicase activity
K2I41_06695	COG0189	ligase activity
K2I41_06710	COG0835	chemotaxis
K2I41_06715	COG0840	transmembrane signaling receptor activity
K2I41_06720	COG0784	Response regulator, receiver
K2I41_06720	COG2198	Histidine kinase
K2I41_06720	COG0643	Histidine kinase
K2I41_06795	COG2304	oxidoreductase activity
K2I41_06800	COG1446	asparaginase
K2I41_06845	COG3537	Alpha-1,2-mannosidase
K2I41_06885	COG1472	Belongs to the glycosyl hydrolase 3 family
K2I41_06895	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K2I41_06900	COG1388	LysM domain
K2I41_06900	COG3858	chitin binding
K2I41_06915	COG0837	glucose binding
K2I41_06920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K2I41_06930	COG0494	nUDIX hydrolase
K2I41_06940	COG3956	TIGRFAM MazG family protein
K2I41_06945	COG1742	UPF0060 membrane protein
K2I41_06955	COG0330	HflC and HflK could
K2I41_06970	COG0509	glycine decarboxylation via glycine cleavage system
K2I41_07005	COG1960	acyl-CoA dehydrogenase activity
K2I41_07015	COG1309	transcriptional regulator
K2I41_07020	COG4771	TonB-dependent receptor
K2I41_07030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K2I41_07040	COG0463	Glycosyl transferase, family 2
K2I41_07045	COG0517	IMP dehydrogenase activity
K2I41_07045	COG0516	GMP reductase activity
K2I41_07055	COG1272	protein, Hemolysin III
K2I41_07065	COG0739	heme binding
K2I41_07070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K2I41_07075	COG0626	cystathionine gamma-synthase activity
K2I41_07085	COG1760	l-serine dehydratase
K2I41_07110	COG2353	YceI-like domain
K2I41_07115	COG0784	Response regulator, receiver
K2I41_07115	COG2198	Histidine kinase
K2I41_07115	COG2205	protein histidine kinase activity
K2I41_07120	COG0784	Response regulator, receiver
K2I41_07120	COG5002	protein histidine kinase activity
K2I41_07160	COG3867	Arabinogalactan endo-beta-1,4-galactanase
K2I41_07180	COG1960	acyl-CoA dehydrogenase activity
K2I41_07220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K2I41_07225	COG0481	GTPase activity
K2I41_07230	COG0681	Belongs to the peptidase S26 family
K2I41_07250	COG1381	Involved in DNA repair and RecF pathway recombination
K2I41_07265	COG2954	triphosphatase activity
K2I41_07270	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K2I41_07275	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
K2I41_07280	COG3046	protein related to deoxyribodipyrimidine photolyase
K2I41_07290	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K2I41_07295	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K2I41_07300	COG1278	Cold shock
K2I41_07320	COG1201	RNA secondary structure unwinding
K2I41_07325	COG1793	dna ligase
K2I41_07335	COG1793	dna ligase
K2I41_07335	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K2I41_07350	COG3706	GGDEF domain
K2I41_07365	COG0183	Belongs to the thiolase family
K2I41_07385	COG1451	nucleotide metabolic process
K2I41_07400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K2I41_07440	COG1047	Peptidyl-prolyl cis-trans
K2I41_07450	COG2824	Alkylphosphonate utilization operon protein PhnA
K2I41_07455	COG3039	Transposase
K2I41_07465	COG1902	pentaerythritol trinitrate reductase activity
K2I41_07470	COG2814	Major facilitator Superfamily
K2I41_07505	COG0392	lysyltransferase activity
K2I41_07505	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K2I41_07515	COG0251	oxidation-reduction process
K2I41_07520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K2I41_07535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K2I41_07560	COG1595	DNA-templated transcription, initiation
K2I41_07575	COG2878	Part of a membrane complex involved in electron transport
K2I41_07585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K2I41_07585	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K2I41_07595	COG0346	lactoylglutathione lyase activity
K2I41_07600	COG0833	amino acid
K2I41_07605	COG2040	homocysteine
K2I41_07620	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K2I41_07640	COG1695	Transcriptional regulator
K2I41_07665	COG1981	membrane
K2I41_07690	COG0825	malonyl-CoA metabolic process
K2I41_07710	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K2I41_07715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K2I41_07720	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K2I41_07725	COG3039	Transposase
K2I41_07735	COG0750	zinc metalloprotease
K2I41_07740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K2I41_07745	COG0575	Belongs to the CDS family
K2I41_07755	COG0233	cytoplasmic translational termination
K2I41_07770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K2I41_07830	COG1393	Belongs to the ArsC family
K2I41_07840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K2I41_07845	COG0367	asparagine synthase
K2I41_07855	COG4774	siderophore transport
K2I41_07875	COG2207	Transcriptional regulator
K2I41_07890	COG1566	PFAM secretion protein HlyD family protein
K2I41_07895	COG2814	Major facilitator Superfamily
K2I41_07995	COG0386	Belongs to the glutathione peroxidase family
K2I41_08060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K2I41_08065	COG0084	hydrolase, TatD family'
K2I41_08080	COG1960	acyl-CoA dehydrogenase activity
K2I41_08095	COG0367	asparagine synthase
K2I41_08105	COG0305	Participates in initiation and elongation during chromosome replication
K2I41_08110	COG0415	Belongs to the DNA photolyase family
K2I41_08125	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_08145	COG3706	GGDEF domain
K2I41_08160	COG0489	protein tyrosine kinase activity
K2I41_08165	COG0717	Belongs to the dCTP deaminase family
K2I41_08190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K2I41_08205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K2I41_08225	COG0433	COG0433 Predicted ATPase
K2I41_08250	COG2890	protein-(glutamine-N5) methyltransferase activity
K2I41_08255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K2I41_08260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K2I41_08265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K2I41_08285	COG0101	tRNA pseudouridine synthase activity
K2I41_08290	COG0135	phosphoribosylanthranilate isomerase activity
K2I41_08300	COG0133	tryptophan synthase activity
K2I41_08315	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K2I41_08320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K2I41_08360	COG0149	triose-phosphate isomerase activity
K2I41_08375	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K2I41_08385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K2I41_08390	COG0649	NAD binding
K2I41_08395	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K2I41_08400	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K2I41_08405	COG1034	ATP synthesis coupled electron transport
K2I41_08410	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K2I41_08440	COG1007	ATP synthesis coupled electron transport
K2I41_08450	COG0779	Required for maturation of 30S ribosomal subunits
K2I41_08455	COG0195	Participates in both transcription termination and antitermination
K2I41_08460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K2I41_08475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K2I41_08480	COG1185	polyribonucleotide nucleotidyltransferase activity
K2I41_08515	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K2I41_08525	COG2095	MarC family integral membrane protein
K2I41_08540	COG1611	Belongs to the LOG family
K2I41_08580	COG4969	Belongs to the N-Me-Phe pilin family
K2I41_08585	COG0556	nucleotide-excision repair
K2I41_08620	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K2I41_08630	COG2986	histidine ammonia-lyase
K2I41_08635	COG1228	amidohydrolase
K2I41_08675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K2I41_08680	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K2I41_08685	COG1605	Chorismate mutase
K2I41_08685	COG0077	Prephenate dehydratase
K2I41_08690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K2I41_08710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K2I41_08715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K2I41_08720	COG0583	DNA-binding transcription factor activity
K2I41_08770	COG3039	Transposase
K2I41_08775	COG1061	Type III restriction enzyme res subunit
K2I41_08780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K2I41_08795	COG3039	Transposase
K2I41_08825	COG3039	Transposase
K2I41_08865	COG2003	Belongs to the UPF0758 family
K2I41_08970	COG3039	Transposase
K2I41_09005	COG0840	transmembrane signaling receptor activity
K2I41_09020	COG5002	protein histidine kinase activity
K2I41_09020	COG2205	protein histidine kinase activity
K2I41_09020	COG0784	Response regulator, receiver
K2I41_09025	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
K2I41_09035	COG0784	Response regulator, receiver
K2I41_09035	COG4191	Histidine kinase
K2I41_09040	COG0784	Response regulator, receiver
K2I41_09040	COG4191	Histidine kinase
K2I41_09055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K2I41_09075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K2I41_09090	COG1595	DNA-templated transcription, initiation
K2I41_09140	COG2244	polysaccharide biosynthetic process
K2I41_09170	COG2264	protein methyltransferase activity
K2I41_09180	COG0438	transferase activity, transferring glycosyl groups
K2I41_09195	COG1136	(ABC) transporter
K2I41_09200	COG1132	(ABC) transporter
K2I41_09210	COG2271	Major facilitator Superfamily
K2I41_09220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K2I41_09235	COG1253	flavin adenine dinucleotide binding
K2I41_09270	COG0504	CTP synthase activity
K2I41_09275	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K2I41_09285	COG0148	phosphopyruvate hydratase activity
K2I41_09290	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K2I41_09305	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K2I41_09320	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K2I41_09325	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K2I41_09330	COG1238	metal cluster binding
K2I41_09345	COG1534	Rna-binding protein
K2I41_09350	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K2I41_09360	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K2I41_09375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K2I41_09380	COG1546	Belongs to the CinA family
K2I41_09395	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K2I41_09400	COG2137	regulation of response to DNA damage stimulus
K2I41_09405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K2I41_09410	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K2I41_09425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K2I41_09435	COG4302	ethanolamine ammonia-lyase activity
K2I41_09445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K2I41_09470	COG2166	iron-sulfur cluster assembly
K2I41_09485	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K2I41_09490	COG0137	argininosuccinate synthase activity
K2I41_09500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K2I41_09505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K2I41_09520	COG0165	Argininosuccinate lyase
K2I41_09570	COG1271	oxidase subunit
K2I41_09580	COG4988	ABC transporter
K2I41_09585	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K2I41_09645	COG4133	protoheme IX ABC transporter activity
K2I41_09650	COG0436	Aminotransferase
K2I41_09670	COG1187	pseudouridine synthase activity
K2I41_09675	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K2I41_09680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K2I41_09685	COG2350	Protein conserved in bacteria
K2I41_09715	COG1175	transmembrane transport
K2I41_09720	COG0395	ABC-type sugar transport system, permease component
K2I41_09745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K2I41_09755	COG2957	Belongs to the agmatine deiminase family
K2I41_09770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K2I41_09775	COG0539	negative regulation of cytoplasmic translation
K2I41_09780	COG0776	regulation of translation
K2I41_09790	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K2I41_09795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K2I41_09805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K2I41_09820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K2I41_09830	COG0519	Catalyzes the synthesis of GMP from XMP
K2I41_09830	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K2I41_09835	COG0582	viral genome integration into host DNA
K2I41_09905	COG1002	Type II restriction enzyme, methylase subunits
K2I41_09910	COG1061	Type III restriction enzyme res subunit
K2I41_09915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K2I41_09930	COG3002	Belongs to the UPF0753 family
K2I41_09935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K2I41_09940	COG0583	DNA-binding transcription factor activity
K2I41_09965	COG0583	DNA-binding transcription factor activity
K2I41_09970	COG0583	DNA-binding transcription factor activity
K2I41_09985	COG2201	protein-glutamate methylesterase activity
K2I41_09990	COG1914	H( )-stimulated, divalent metal cation uptake system
K2I41_10010	COG0668	transmembrane transport
K2I41_10035	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_10040	COG1183	phosphatidylcholine synthase activity
K2I41_10050	COG3243	poly(R)-hydroxyalkanoic acid synthase
K2I41_10065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2I41_10065	COG0723	plastoquinol--plastocyanin reductase activity
K2I41_10075	COG2183	response to ionizing radiation
K2I41_10085	COG0784	Response regulator, receiver
K2I41_10085	COG2205	protein histidine kinase activity
K2I41_10205	COG3039	Transposase
K2I41_10210	COG3039	Transposase
K2I41_10230	COG3039	Transposase
K2I41_10235	COG0800	Aldolase
K2I41_10240	COG0129	dihydroxy-acid dehydratase activity
K2I41_10245	COG0363	glucosamine-6-phosphate deaminase activity
K2I41_10255	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K2I41_10270	COG0354	folic acid binding
K2I41_10285	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K2I41_10300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K2I41_10315	COG4591	ABC-type transport system involved in lipoprotein release permease component
K2I41_10340	COG0811	peptide transport
K2I41_10355	COG1663	tetraacyldisaccharide 4'-kinase activity
K2I41_10365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K2I41_10375	COG0322	excinuclease ABC activity
K2I41_10425	COG3039	Transposase
K2I41_10465	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K2I41_10485	COG1054	Belongs to the UPF0176 family
K2I41_10495	COG1530	ribonuclease E activity
K2I41_10525	COG2154	pterin-4-alpha-carbinolamine dehydratase
K2I41_10685	COG0631	protein serine/threonine phosphatase activity
K2I41_10690	COG0515	serine threonine protein kinase
K2I41_10720	COG1858	cytochrome C peroxidase
K2I41_10775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K2I41_10780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K2I41_10835	COG2201	protein-glutamate methylesterase activity
K2I41_10875	COG4566	intracellular signal transduction
K2I41_10885	COG5001	Diguanylate cyclase
K2I41_10945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K2I41_10945	COG1648	precorrin-2 dehydrogenase activity
K2I41_10970	COG0746	molybdenum cofactor guanylyltransferase activity
K2I41_11000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K2I41_11015	COG0303	'Molybdopterin
K2I41_11030	COG1160	GTP binding
K2I41_11035	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K2I41_11055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K2I41_11070	COG1024	Enoyl-CoA hydratase
K2I41_11070	COG1250	3-hydroxyacyl-CoA dehydrogenase
K2I41_11075	COG0183	Belongs to the thiolase family
K2I41_11080	COG0038	chloride channel
K2I41_11100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K2I41_11120	COG1674	ftsk spoiiie
K2I41_11125	COG0492	ferredoxin-NADP+ reductase activity
K2I41_11190	COG0653	protein targeting
K2I41_11200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K2I41_11230	COG0542	response to heat
K2I41_11245	COG0482	sulfurtransferase activity
K2I41_11275	COG4585	Histidine kinase
K2I41_11285	COG4191	Histidine kinase
K2I41_11305	COG0784	Response regulator, receiver
K2I41_11305	COG0835	chemotaxis
K2I41_11315	COG1558	bacterial-type flagellum-dependent cell motility
K2I41_11320	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K2I41_11330	COG4787	bacterial-type flagellum-dependent cell motility
K2I41_11350	COG1705	Flagellar rod assembly protein muramidase FlgJ
K2I41_11350	COG3951	Flagellar rod assembly protein muramidase FlgJ
K2I41_11365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K2I41_11370	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K2I41_11400	COG2201	protein-glutamate methylesterase activity
K2I41_11420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K2I41_11425	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_11430	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_11465	COG3039	Transposase
K2I41_11470	COG1677	Flagellar hook-basal body complex protein FliE
K2I41_11520	COG3190	flagellar
K2I41_11535	COG1684	flagellar biosynthetic protein fliR
K2I41_11590	COG0784	Response regulator, receiver
K2I41_11590	COG2198	Histidine kinase
K2I41_11590	COG0643	Histidine kinase
K2I41_11720	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K2I41_11725	COG1360	Flagellar Motor Protein
K2I41_11730	COG1192	Involved in chromosome partitioning
K2I41_11735	COG0835	chemotaxis
K2I41_11745	COG0745	RESPONSE REGULATOR receiver
K2I41_11755	COG0840	transmembrane signaling receptor activity
K2I41_11780	COG0840	transmembrane signaling receptor activity
K2I41_11785	COG0840	transmembrane signaling receptor activity
K2I41_11790	COG0840	transmembrane signaling receptor activity
K2I41_11800	COG0840	transmembrane signaling receptor activity
K2I41_11805	COG0840	transmembrane signaling receptor activity
K2I41_11810	COG0840	transmembrane signaling receptor activity
K2I41_11815	COG0840	transmembrane signaling receptor activity
K2I41_11820	COG0840	transmembrane signaling receptor activity
K2I41_11835	COG0835	chemotaxis
K2I41_11845	COG0840	transmembrane signaling receptor activity
K2I41_11875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K2I41_11905	COG0318	PFAM AMP-dependent synthetase and ligase
K2I41_11910	COG1024	Enoyl-CoA hydratase
K2I41_11915	COG2205	protein histidine kinase activity
K2I41_11915	COG2198	Histidine kinase
K2I41_11915	COG0784	Response regulator, receiver
K2I41_11935	COG3279	Response regulator of the LytR AlgR family
K2I41_11950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K2I41_11960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K2I41_11965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K2I41_11975	COG0505	Belongs to the CarA family
K2I41_11980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K2I41_11985	COG2258	MOSC domain
K2I41_11990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K2I41_12040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K2I41_12060	COG0277	FAD linked oxidase domain protein
K2I41_12065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K2I41_12075	COG0531	amino acid
K2I41_12080	COG0531	amino acid
K2I41_12085	COG0235	Class ii aldolase
K2I41_12090	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K2I41_12110	COG0140	phosphoribosyl-ATP diphosphatase activity
K2I41_12110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K2I41_12120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K2I41_12130	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K2I41_12130	COG0131	Imidazoleglycerol-phosphate dehydratase
K2I41_12145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K2I41_12155	COG3039	Transposase
K2I41_12165	COG0124	histidyl-tRNA synthetase
K2I41_12180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K2I41_12235	COG1012	belongs to the aldehyde dehydrogenase family
K2I41_12260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K2I41_12265	COG0697	spore germination
K2I41_12270	COG1794	racemase activity, acting on amino acids and derivatives
K2I41_12285	COG0671	phosphoesterase, PA-phosphatase related
K2I41_12300	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K2I41_12305	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K2I41_12315	COG5001	Diguanylate cyclase
K2I41_12315	COG4251	negative regulation of phosphorylation
K2I41_12315	COG3706	GGDEF domain
K2I41_12315	COG2203	Gaf domain
K2I41_12330	COG1472	Belongs to the glycosyl hydrolase 3 family
K2I41_12355	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K2I41_12375	COG0617	tRNA 3'-terminal CCA addition
K2I41_12385	COG1469	GTP cyclohydrolase I activity
K2I41_12390	COG0860	N-Acetylmuramoyl-L-alanine amidase
K2I41_12400	COG0477	Major facilitator Superfamily
K2I41_12410	COG1070	Carbohydrate kinase
K2I41_12435	COG0800	Aldolase
K2I41_12440	COG4948	Mandelate Racemase Muconate Lactonizing
K2I41_12450	COG3734	2-keto-3-deoxy-galactonokinase
K2I41_12455	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K2I41_12465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K2I41_12480	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K2I41_12485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K2I41_12495	COG0352	thiamine-phosphate diphosphorylase activity
K2I41_12495	COG0351	phosphomethylpyrimidine kinase
K2I41_12520	COG0583	DNA-binding transcription factor activity
K2I41_12525	COG1741	Belongs to the pirin family
K2I41_12570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K2I41_12575	COG0402	S-adenosylhomocysteine deaminase activity
K2I41_12590	COG1509	lysine 2,3-aminomutase activity
K2I41_12595	COG3300	MHYT domain
K2I41_12595	COG5001	Diguanylate cyclase
K2I41_12610	COG0483	inositol monophosphate 1-phosphatase activity
K2I41_12615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K2I41_12640	COG0488	(ABC) transporter
K2I41_12645	COG0513	Belongs to the DEAD box helicase family
K2I41_12655	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K2I41_12665	COG0625	glutathione transferase activity
K2I41_12675	COG1671	Belongs to the UPF0178 family
K2I41_12680	COG4681	YaeQ
K2I41_12685	COG2081	HI0933 family
K2I41_12705	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_12725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K2I41_12730	COG0860	N-Acetylmuramoyl-L-alanine amidase
K2I41_12735	COG0802	atpase or kinase
K2I41_12740	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K2I41_12740	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K2I41_12745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K2I41_12765	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K2I41_12835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K2I41_12935	COG2801	Transposase and inactivated derivatives
K2I41_12950	COG0835	chemotaxis
K2I41_12955	COG0840	transmembrane signaling receptor activity
K2I41_12980	COG2969	positive regulation of protein catabolic process
K2I41_12985	COG0625	glutathione transferase activity
K2I41_12990	COG2857	Cytochrome c1
K2I41_12995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K2I41_13000	COG0723	plastoquinol--plastocyanin reductase activity
K2I41_13005	COG0741	lytic transglycosylase activity
K2I41_13030	COG1702	phosphate starvation-inducible protein PhoH
K2I41_13050	COG4535	Mg2 and Co2 transporter CorC
K2I41_13065	COG1012	belongs to the aldehyde dehydrogenase family
K2I41_13070	COG1177	transmembrane transport
K2I41_13075	COG1176	ABC-type spermidine putrescine transport system, permease component I
K2I41_13085	COG3842	ATPase activity
K2I41_13105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K2I41_13140	COG2201	protein-glutamate methylesterase activity
K2I41_13185	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K2I41_13190	COG0174	glutamine synthetase
K2I41_13195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2I41_13205	COG0477	Major facilitator Superfamily
K2I41_13215	COG0243	molybdopterin cofactor binding
K2I41_13235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K2I41_13245	COG3039	Transposase
K2I41_13250	COG3039	Transposase
K2I41_13265	COG2733	membrane
K2I41_13270	COG2205	protein histidine kinase activity
K2I41_13270	COG0784	Response regulator, receiver
K2I41_13270	COG5002	protein histidine kinase activity
K2I41_13285	COG0477	Major facilitator Superfamily
K2I41_13295	COG2902	Dehydrogenase
K2I41_13305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K2I41_13310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K2I41_13320	COG1609	Transcriptional regulator
K2I41_13325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K2I41_13325	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K2I41_13330	COG1105	Belongs to the carbohydrate kinase PfkB family
K2I41_13335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K2I41_13335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K2I41_13345	COG3039	Transposase
K2I41_13390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K2I41_13395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K2I41_13400	COG1862	Preprotein translocase
K2I41_13405	COG0343	queuine tRNA-ribosyltransferase activity
K2I41_13465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K2I41_13475	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K2I41_13480	COG0742	ribosomal rna small subunit methyltransferase
K2I41_13485	COG0326	Molecular chaperone. Has ATPase activity
K2I41_13525	COG4206	TonB-dependent receptor
K2I41_13575	COG0531	amino acid
K2I41_13590	COG0006	proline dipeptidase activity
K2I41_13600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K2I41_13615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2I41_13620	COG3938	Belongs to the proline racemase family
K2I41_13630	COG0552	protein localization to endoplasmic reticulum
K2I41_13640	COG1194	a g-specific adenine glycosylase
K2I41_13650	COG0784	Response regulator, receiver
K2I41_13650	COG4191	Histidine kinase
K2I41_13655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K2I41_13675	COG3040	lipid binding
K2I41_13685	COG1960	acyl-CoA dehydrogenase activity
K2I41_13695	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K2I41_13725	COG0438	transferase activity, transferring glycosyl groups
K2I41_13735	COG0438	transferase activity, transferring glycosyl groups
K2I41_13740	COG0438	transferase activity, transferring glycosyl groups
K2I41_13795	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K2I41_13810	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K2I41_13830	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K2I41_13845	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K2I41_13865	COG3115	cell septum assembly
K2I41_13885	COG0360	Binds together with S18 to 16S ribosomal RNA
K2I41_13890	COG0316	Belongs to the HesB IscA family
K2I41_13920	COG0288	reversible hydration of carbon dioxide
K2I41_13935	COG3844	kynureninase activity
K2I41_13945	COG2925	Exonuclease
K2I41_13955	COG0667	Aldo Keto reductase
K2I41_13980	COG0116	Belongs to the methyltransferase superfamily
K2I41_13980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K2I41_14025	COG0494	nUDIX hydrolase
K2I41_14035	COG1024	Enoyl-CoA hydratase
K2I41_14045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K2I41_14075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K2I41_14080	COG0573	inorganic phosphate transmembrane transporter activity
K2I41_14095	COG0704	Plays a role in the regulation of phosphate uptake
K2I41_14105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K2I41_14115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K2I41_14130	COG0557	exoribonuclease II activity
K2I41_14155	COG1960	acyl-CoA dehydrogenase activity
K2I41_14160	COG2226	methyltransferase
K2I41_14180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K2I41_14190	COG1609	Transcriptional regulator
K2I41_14205	COG2900	Belongs to the SlyX family
K2I41_14220	COG0386	Belongs to the glutathione peroxidase family
K2I41_14230	COG1725	Transcriptional regulator
K2I41_14235	COG1131	(ABC) transporter
K2I41_14295	COG2850	peptidyl-arginine hydroxylation
K2I41_14330	COG1132	(ABC) transporter
K2I41_14340	COG0583	DNA-binding transcription factor activity
K2I41_14365	COG3039	Transposase
K2I41_14380	COG3039	Transposase
K2I41_14405	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K2I41_14410	COG0484	heat shock protein binding
K2I41_14415	COG0443	Heat shock 70 kDa protein
K2I41_14420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K2I41_14430	COG0497	DNA recombination
K2I41_14440	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K2I41_14445	COG2914	Belongs to the UPF0125 (RnfH) family
K2I41_14455	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K2I41_14540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K2I41_14545	COG2311	Membrane
K2I41_14550	COG1047	Peptidyl-prolyl cis-trans
K2I41_14555	COG0791	NLP P60 protein
K2I41_14560	COG0791	NLP P60 protein
K2I41_14570	COG4106	trans-aconitate 2-methyltransferase activity
K2I41_14575	COG1301	dicarboxylic acid transport
K2I41_14580	COG1785	Belongs to the alkaline phosphatase family
K2I41_14585	COG0037	tRNA processing
K2I41_14590	COG1722	exodeoxyribonuclease VII activity
K2I41_14595	COG0142	geranyltranstransferase activity
K2I41_14600	COG4104	PAAR repeat-containing protein
K2I41_14620	COG0312	modulator of DNA gyrase
K2I41_14625	COG3028	Belongs to the UPF0307 family
K2I41_14630	COG0312	modulator of DNA gyrase
K2I41_14640	COG3164	Protein of unknown function
K2I41_14655	COG2968	Membrane
K2I41_14685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K2I41_14705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K2I41_14730	COG3118	belongs to the thioredoxin family
K2I41_14795	COG1132	(ABC) transporter
K2I41_14825	COG0745	RESPONSE REGULATOR receiver
K2I41_14830	COG5002	protein histidine kinase activity
K2I41_14830	COG5000	phosphorelay sensor kinase activity
K2I41_14835	COG0475	glutathione-regulated potassium exporter activity
K2I41_14845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K2I41_14865	COG1187	pseudouridine synthase activity
K2I41_14870	COG5002	protein histidine kinase activity
K2I41_14870	COG5001	Diguanylate cyclase
K2I41_14920	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K2I41_14995	COG0735	belongs to the Fur family
K2I41_15000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K2I41_15035	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K2I41_15045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K2I41_15060	COG0643	Histidine kinase
K2I41_15060	COG2198	Histidine kinase
K2I41_15065	COG0840	transmembrane signaling receptor activity
K2I41_15070	COG0835	chemotaxis
K2I41_15075	COG2199	diguanylate cyclase activity
K2I41_15075	COG2202	Pas domain
K2I41_15075	COG2200	EAL domain
K2I41_15080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K2I41_15165	COG1515	deoxyribonuclease V activity
K2I41_15175	COG1741	Belongs to the pirin family
K2I41_15215	COG3039	Transposase
K2I41_15240	COG3039	Transposase
K2I41_15255	COG3039	Transposase
K2I41_15270	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K2I41_15280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K2I41_15290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K2I41_15310	COG1741	Belongs to the pirin family
K2I41_15315	COG1966	Carbon starvation protein
K2I41_15320	COG2879	small protein
K2I41_15370	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K2I41_15375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K2I41_15380	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K2I41_15385	COG2080	2 iron, 2 sulfur cluster binding
K2I41_15395	COG5001	Diguanylate cyclase
K2I41_15395	COG4251	negative regulation of phosphorylation
K2I41_15395	COG3706	GGDEF domain
K2I41_15395	COG2203	Gaf domain
K2I41_15400	COG0629	single-stranded DNA binding
K2I41_15405	COG0142	geranyltranstransferase activity
K2I41_15430	COG0527	aspartate kinase activity
K2I41_15440	COG0384	phenazine biosynthesis protein PhzF
K2I41_15450	COG1764	response to oxidative stress
K2I41_15465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K2I41_15470	COG1678	Uncharacterized ACR, COG1678
K2I41_15480	COG0519	Catalyzes the synthesis of GMP from XMP
K2I41_15510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K2I41_15565	COG1959	2 iron, 2 sulfur cluster binding
K2I41_15570	COG0719	Fe-S assembly protein
K2I41_15575	COG0396	ATPase activity
K2I41_15580	COG0719	Fe-S assembly protein
K2I41_15585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K2I41_15595	COG2146	nitrite reductase [NAD(P)H] activity
K2I41_15610	COG1555	photosystem II stabilization
K2I41_15615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K2I41_15630	COG3178	'Phosphotransferase
K2I41_15635	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K2I41_15645	COG0628	permease
K2I41_15655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K2I41_15670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K2I41_15690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K2I41_15695	COG0271	Belongs to the BolA IbaG family
K2I41_15705	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K2I41_15715	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K2I41_15720	COG1137	ATPase activity
K2I41_15735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K2I41_15745	COG1660	Displays ATPase and GTPase activities
K2I41_15755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K2I41_15760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K2I41_15765	COG2239	Acts as a magnesium transporter
K2I41_15775	COG1294	oxidase, subunit
K2I41_15780	COG1271	oxidase subunit
K2I41_15790	COG1113	amino acid transport
K2I41_15805	COG2197	response regulator
K2I41_15810	COG0531	amino acid
K2I41_15865	COG0754	glutathionylspermidine amidase activity
K2I41_15890	COG1842	Phage shock protein A
K2I41_15905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K2I41_15935	COG3039	Transposase
K2I41_15950	COG3039	Transposase
K2I41_15965	COG3039	Transposase
K2I41_16015	COG3039	Transposase
K2I41_16130	COG3179	chitinase
K2I41_16285	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K2I41_16310	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K2I41_16325	COG2197	response regulator
K2I41_16330	COG4585	Histidine kinase
K2I41_16345	COG2894	cell division
K2I41_16350	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K2I41_16360	COG0642	Histidine kinase
K2I41_16365	COG0745	RESPONSE REGULATOR receiver
K2I41_16370	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K2I41_16380	COG2194	sulfuric ester hydrolase activity
K2I41_16410	COG3551	Protein conserved in bacteria
K2I41_16440	COG3039	Transposase
K2I41_16460	COG0753	catalase activity
K2I41_16495	COG2207	Transcriptional regulator
K2I41_16495	COG1917	Cupin 2, conserved barrel domain protein
K2I41_16505	COG0823	Involved in the tonB-independent uptake of proteins
K2I41_16505	COG1506	peptidase
K2I41_16520	COG1297	OPT oligopeptide transporter protein
K2I41_16535	COG0587	DNA-directed DNA polymerase activity
K2I41_16575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K2I41_16655	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
K2I41_16710	COG0308	aminopeptidase N
K2I41_16725	COG0330	HflC and HflK could
K2I41_16730	COG0330	HflC and HflK could
K2I41_16750	COG0678	peroxiredoxin activity
K2I41_16810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K2I41_16825	COG3829	transcription factor binding
K2I41_16835	COG3039	Transposase
K2I41_16860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K2I41_16865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K2I41_16875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2I41_16880	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_16905	COG1399	metal-binding, possibly nucleic acid-binding protein
K2I41_16925	COG0714	Associated with various cellular activities
K2I41_16945	COG0537	adenosine 5'-monophosphoramidase activity
K2I41_16955	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K2I41_16975	COG0314	molybdopterin synthase activity
K2I41_16980	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K2I41_16985	COG0315	cyclic pyranopterin monophosphate synthase activity
K2I41_16995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K2I41_17000	COG1234	tRNA 3'-trailer cleavage
K2I41_17005	COG3642	lipopolysaccharide core region biosynthetic process
K2I41_17010	COG0859	PFAM glycosyl transferase family 9
K2I41_17025	COG0631	protein serine/threonine phosphatase activity
K2I41_17030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K2I41_17055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K2I41_17095	COG0544	peptidyl-prolyl cis-trans isomerase activity
K2I41_17140	COG0473	3-isopropylmalate dehydrogenase activity
K2I41_17155	COG4783	chaperone-mediated protein folding
K2I41_17170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K2I41_17180	COG0438	transferase activity, transferring glycosyl groups
K2I41_17185	COG0671	phosphoesterase, PA-phosphatase related
K2I41_17190	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K2I41_17215	COG2833	Protein of unknown function (DUF455)
K2I41_17235	COG0285	dihydrofolate synthase activity
K2I41_17240	COG0406	alpha-ribazole phosphatase activity
K2I41_17275	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K2I41_17280	COG4208	sulfate ABC transporter
K2I41_17285	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K2I41_17290	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
K2I41_17295	COG0156	8-amino-7-oxononanoate synthase activity
K2I41_17320	COG0604	alcohol dehydrogenase
K2I41_17325	COG1902	pentaerythritol trinitrate reductase activity
K2I41_17325	COG0446	pyridine nucleotide-disulphide oxidoreductase
K2I41_17360	COG0584	glycerophosphoryl diester phosphodiesterase
K2I41_17385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K2I41_17390	COG1217	gtp-binding protein TYPA
K2I41_17410	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K2I41_17425	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K2I41_17430	COG0203	ribosomal protein L17
K2I41_17440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K2I41_17445	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K2I41_17455	COG0201	protein transport
K2I41_17460	COG0200	Binds to the 23S rRNA
K2I41_17465	COG1841	ribosomal large subunit assembly
K2I41_17495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K2I41_17500	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K2I41_17505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K2I41_17510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K2I41_17515	COG0255	Belongs to the universal ribosomal protein uL29 family
K2I41_17520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K2I41_17530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K2I41_17540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K2I41_17545	COG0089	rRNA binding
K2I41_17550	COG0088	Forms part of the polypeptide exit tunnel
K2I41_17560	COG0051	transcription antitermination factor activity, RNA binding
K2I41_17580	COG0049	tRNA binding
K2I41_17585	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K2I41_17590	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K2I41_17595	COG0085	RNA polymerase activity
K2I41_17605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K2I41_17610	COG0081	regulation of translation
K2I41_17615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K2I41_17620	COG0250	Participates in transcription elongation, termination and antitermination
K2I41_17625	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K2I41_17655	COG0012	GTP binding
K2I41_17660	COG0193	aminoacyl-tRNA hydrolase activity
K2I41_17670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K2I41_17685	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K2I41_17695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K2I41_17700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K2I41_17710	COG0521	Mo-molybdopterin cofactor biosynthetic process
K2I41_17730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K2I41_17735	COG1295	ribonuclease BN
K2I41_17770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K2I41_17780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K2I41_17835	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K2I41_17880	COG2890	protein-(glutamine-N5) methyltransferase activity
K2I41_17890	COG3634	alkyl hydroperoxide reductase activity
K2I41_17895	COG0583	DNA-binding transcription factor activity
K2I41_17905	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K2I41_17910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K2I41_17920	COG2197	response regulator
K2I41_17950	COG0697	spore germination
K2I41_17980	COG3386	PFAM SMP-30 Gluconolaconase
K2I41_18000	COG1024	Enoyl-CoA hydratase
K2I41_18010	COG0318	PFAM AMP-dependent synthetase and ligase
K2I41_18015	COG0583	DNA-binding transcription factor activity
K2I41_18020	COG3384	dioxygenase
K2I41_18050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K2I41_18055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K2I41_18065	COG2096	Adenosyltransferase
K2I41_18070	COG0123	including yeast histone deacetylase and acetoin utilization protein
K2I41_18085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K2I41_18095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K2I41_18100	COG2967	ApaG domain
K2I41_18105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K2I41_18125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K2I41_18145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K2I41_18160	COG0642	Histidine kinase
K2I41_18175	COG4181	ATPase activity
K2I41_18185	COG2175	clavaminate synthase activity
K2I41_18200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K2I41_18220	COG0667	Aldo Keto reductase
K2I41_18230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K2I41_18235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K2I41_18245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K2I41_18260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K2I41_18300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K2I41_18305	COG2226	methyltransferase
K2I41_18350	COG0604	alcohol dehydrogenase
K2I41_18350	COG3321	synthase
K2I41_18350	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_18360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K2I41_18375	COG0494	nUDIX hydrolase
K2I41_18390	COG4942	peptidase
K2I41_18390	COG1388	LysM domain
K2I41_18400	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K2I41_18420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K2I41_18425	COG1181	Belongs to the D-alanine--D-alanine ligase family
K2I41_18430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K2I41_18445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K2I41_18450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K2I41_18465	COG3116	cell division
K2I41_18470	COG0275	rRNA processing
K2I41_18510	COG0792	nuclease activity
K2I41_18515	COG1988	membrane-bound metal-dependent
K2I41_18520	COG0277	FAD linked oxidase domain protein
K2I41_18525	COG0745	RESPONSE REGULATOR receiver
K2I41_18530	COG2205	protein histidine kinase activity
K2I41_18540	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K2I41_18545	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K2I41_18565	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K2I41_18570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K2I41_18575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K2I41_18595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K2I41_18595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K2I41_18605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K2I41_18615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K2I41_18635	COG0488	(ABC) transporter
K2I41_18685	COG2205	protein histidine kinase activity
K2I41_18725	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K2I41_18785	COG1649	PFAM Uncharacterised BCR, COG1649
K2I41_18785	COG0726	polysaccharide deacetylase
K2I41_18790	COG1215	transferase activity, transferring glycosyl groups
K2I41_18800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K2I41_18805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K2I41_18810	COG1609	Transcriptional regulator
K2I41_18820	COG2188	Transcriptional regulator
K2I41_18835	COG3250	beta-galactosidase activity
K2I41_18870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K2I41_18875	COG4191	Histidine kinase
K2I41_18880	COG0784	Response regulator, receiver
K2I41_18885	COG4251	negative regulation of phosphorylation
K2I41_18890	COG2823	Periplasmic or secreted lipoprotein
K2I41_18895	COG0673	inositol 2-dehydrogenase activity
K2I41_18900	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K2I41_18935	COG1051	belongs to the nudix hydrolase family
K2I41_18935	COG1056	cytidyltransferase-related domain
K2I41_18960	COG2921	Belongs to the UPF0250 family
K2I41_18975	COG1686	Belongs to the peptidase S11 family
K2I41_18980	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K2I41_18985	COG2951	lytic endotransglycosylase activity
K2I41_19030	COG0772	Belongs to the SEDS family
K2I41_19045	COG1792	Involved in formation and maintenance of cell shape
K2I41_19050	COG1077	Cell shape determining protein MreB Mrl
K2I41_19055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K2I41_19075	COG3300	MHYT domain
K2I41_19075	COG5001	Diguanylate cyclase
K2I41_19125	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K2I41_19145	COG2832	Protein of unknown function (DUF454)
K2I41_19155	COG0436	Aminotransferase
K2I41_19165	COG1505	serine-type exopeptidase activity
K2I41_19190	COG0181	hydroxymethylbilane synthase activity
K2I41_19200	COG3275	phosphorelay sensor kinase activity
K2I41_19230	COG0659	secondary active sulfate transmembrane transporter activity
K2I41_19305	COG0598	Magnesium transport protein CorA
K2I41_19315	COG1113	amino acid transport
K2I41_19335	COG4305	rare lipoprotein A
K2I41_19340	COG0697	spore germination
K2I41_19410	COG4221	oxidoreductase activity
K2I41_19450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K2I41_19475	COG0459	protein refolding
K2I41_19505	COG2860	membrane
K2I41_19510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K2I41_19515	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K2I41_19520	COG2201	protein-glutamate methylesterase activity
K2I41_19525	COG2177	Part of the ABC transporter FtsEX involved in
K2I41_19530	COG2884	Cell division ATP-binding protein ftsE
K2I41_19540	COG3118	belongs to the thioredoxin family
K2I41_19545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K2I41_19580	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K2I41_19580	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K2I41_19590	COG1473	amidohydrolase
K2I41_19595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K2I41_19600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K2I41_19630	COG5383	Protein conserved in bacteria
K2I41_19670	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K2I41_19675	COG3023	N-Acetylmuramoyl-L-alanine amidase
K2I41_19685	COG4948	Mandelate Racemase Muconate Lactonizing
K2I41_19700	COG0531	amino acid
K2I41_19720	COG4682	membrane
K2I41_19725	COG2133	pyrroloquinoline quinone binding
K2I41_19745	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K2I41_19750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K2I41_19760	COG1610	YqeY-like protein
K2I41_19775	COG1295	ribonuclease BN
K2I41_19780	COG0358	DNA primase activity
K2I41_19835	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K2I41_19850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K2I41_19905	COG0739	heme binding
K2I41_19920	COG2211	Major facilitator Superfamily
K2I41_19925	COG0708	Exodeoxyribonuclease III
K2I41_19970	COG2111	Na H antiporter
K2I41_19970	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K2I41_19975	COG1006	Multisubunit Na H antiporter MnhC subunit
K2I41_19980	COG0651	ATP synthesis coupled electron transport
K2I41_19990	COG2212	antiporter activity
K2I41_19995	COG1320	monovalent cation:proton antiporter activity
K2I41_20005	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K2I41_20030	COG3104	oligopeptide transport
K2I41_20035	COG3483	tryptophan 2,3-dioxygenase activity
K2I41_20045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K2I41_20060	COG0508	dehydrogenase complex catalyzes the overall conversion of
K2I41_20075	COG3039	Transposase
K2I41_20080	COG0513	Belongs to the DEAD box helicase family
K2I41_20200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K2I41_20205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K2I41_20215	COG0045	succinate-CoA ligase (ADP-forming) activity
K2I41_20215	COG1042	CoA-binding domain protein
K2I41_20215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K2I41_20225	COG2239	Acts as a magnesium transporter
K2I41_20275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K2I41_20305	COG3100	YcgL domain-containing protein
K2I41_20310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K2I41_20320	COG0463	Glycosyl transferase, family 2
K2I41_20340	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_20380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K2I41_20395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K2I41_20440	COG0408	coproporphyrinogen oxidase activity
K2I41_20510	COG0210	DNA helicase
K2I41_20525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K2I41_20530	COG0583	DNA-binding transcription factor activity
K2I41_20535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K2I41_20545	COG2159	amidohydrolase
K2I41_20570	COG0357	Ribosomal RNA small subunit methyltransferase G
K2I41_20575	COG3540	Alkaline phosphatase
K2I41_20585	COG2091	lysine biosynthetic process via aminoadipic acid
K2I41_20600	COG0708	Exodeoxyribonuclease III
K2I41_20615	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K2I41_20620	COG3162	membrane
K2I41_20660	COG1414	Transcriptional regulator
K2I41_20670	COG2205	protein histidine kinase activity
K2I41_20680	COG3459	Glycosyltransferase 36 associated
K2I41_20690	COG3265	gluconokinase activity
K2I41_20695	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K2I41_20700	COG3039	Transposase
K2I41_20715	COG0339	signal peptide processing
K2I41_20745	COG0564	pseudouridine synthase activity
K2I41_20760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K2I41_20770	COG1181	Belongs to the D-alanine--D-alanine ligase family
K2I41_20780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K2I41_20785	COG0318	PFAM AMP-dependent synthetase and ligase
K2I41_20790	COG0727	PFAM Uncharacterised protein family (UPF0153)
K2I41_20795	COG0596	Alpha beta hydrolase
K2I41_20800	COG3177	Filamentation induced by cAMP protein fic
K2I41_20805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K2I41_20820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K2I41_20845	COG4191	Histidine kinase
K2I41_20850	COG0028	Belongs to the TPP enzyme family
K2I41_20865	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K2I41_20870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K2I41_20915	COG0183	Belongs to the thiolase family
K2I41_20945	COG3039	Transposase
K2I41_20970	COG2032	superoxide dismutase activity
K2I41_20975	COG2032	superoxide dismutase activity
K2I41_20980	COG2204	response regulator
K2I41_20985	COG3852	Histidine kinase
K2I41_20990	COG0004	ammonium transporteR
K2I41_20995	COG0347	Belongs to the P(II) protein family
K2I41_21000	COG0174	glutamine synthetase
K2I41_21005	COG1968	undecaprenyl-diphosphatase activity
K2I41_21050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K2I41_21060	COG2062	phosphohistidine phosphatase, SixA
K2I41_21065	COG0489	protein tyrosine kinase activity
K2I41_21085	COG1396	sequence-specific DNA binding
K2I41_21090	COG3550	peptidyl-serine autophosphorylation
K2I41_21095	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
K2I41_21100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K2I41_21115	COG1125	glycine betaine transport
K2I41_21115	COG0517	IMP dehydrogenase activity
K2I41_21130	COG1119	ATPase activity
K2I41_21140	COG1473	amidohydrolase
K2I41_21145	COG1752	Esterase of the alpha-beta hydrolase superfamily
K2I41_21155	COG1522	sequence-specific DNA binding
K2I41_21160	COG3186	Phenylalanine-4-hydroxylase
K2I41_21180	COG1609	Transcriptional regulator
K2I41_21205	COG0366	Alpha amylase catalytic
K2I41_21210	COG0366	Alpha amylase catalytic
K2I41_21225	COG3039	Transposase
K2I41_21255	COG3039	Transposase
K2I41_21320	COG3135	benzoate transporter
K2I41_21340	COG0676	glucose-6-phosphate 1-epimerase activity
K2I41_21395	COG0302	gtp cyclohydrolase
K2I41_21425	COG0477	Major facilitator Superfamily
K2I41_21470	COG3237	CsbD-like
K2I41_21560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K2I41_21570	COG3039	Transposase
K2I41_21595	COG1755	Isoprenylcysteine carboxyl methyltransferase
K2I41_21600	COG1304	FMN binding
K2I41_21605	COG3039	Transposase
K2I41_21615	COG4772	TonB-dependent receptor
K2I41_21625	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K2I41_21650	COG1272	protein, Hemolysin III
K2I41_21655	COG1205	dead DEAH box helicase
K2I41_21655	COG1111	helicase
K2I41_21715	COG0067	glutamate synthase
K2I41_21715	COG0069	glutamate synthase activity
K2I41_21715	COG0070	glutamate synthase
K2I41_21720	COG0493	'glutamate synthase
K2I41_21730	COG0531	amino acid
K2I41_21740	COG1322	Protein conserved in bacteria
K2I41_21750	COG0386	Belongs to the glutathione peroxidase family
K2I41_21755	COG2853	Lipoprotein
K2I41_21770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K2I41_21775	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K2I41_21780	COG1127	ABC transporter
K2I41_21815	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K2I41_21820	COG1074	ATP-dependent DNA helicase activity
K2I41_21825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K2I41_21895	COG2124	cytochrome p450
K2I41_21900	COG2124	cytochrome p450
K2I41_21905	COG2124	cytochrome p450
K2I41_21910	COG1141	Ferredoxin
K2I41_21915	COG1028	Short-chain dehydrogenase reductase Sdr
K2I41_21920	COG2124	cytochrome p450
K2I41_21925	COG0142	geranyltranstransferase activity
K2I41_21930	COG1657	PFAM Prenyltransferase squalene oxidase
K2I41_21940	COG1304	FMN binding
K2I41_21955	COG0564	pseudouridine synthase activity
K2I41_21980	COG3706	GGDEF domain
K2I41_21990	COG1929	Belongs to the glycerate kinase type-1 family
K2I41_21995	COG2271	Major facilitator Superfamily
K2I41_22010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K2I41_22015	COG0861	Integral membrane protein TerC family
K2I41_22025	COG0584	glycerophosphoryl diester phosphodiesterase
K2I41_22035	COG0671	phosphoesterase, PA-phosphatase related
K2I41_22040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K2I41_22045	COG0726	polysaccharide deacetylase