locus-tag	class	description
H4J00_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H4J00_00020	COG0187	DNA topoisomerase II activity
H4J00_00030	COG0501	Belongs to the peptidase M48B family
H4J00_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H4J00_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4J00_00085	COG1064	alcohol dehydrogenase
H4J00_00090	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H4J00_00100	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H4J00_00115	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H4J00_00125	COG2234	aminopeptidase activity
H4J00_00135	COG4942	peptidase
H4J00_00140	COG0793	Belongs to the peptidase S41A family
H4J00_00185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H4J00_00205	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H4J00_00220	COG0210	DNA helicase
H4J00_00240	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H4J00_00245	COG0284	orotidine-5'-phosphate decarboxylase activity
H4J00_00275	COG2937	Belongs to the GPAT DAPAT family
H4J00_00280	COG0604	alcohol dehydrogenase
H4J00_00280	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_00280	COG3321	synthase
H4J00_00320	COG2211	Major facilitator Superfamily
H4J00_00340	COG3693	PFAM glycoside hydrolase, family 10
H4J00_00375	COG4770	biotin carboxylase activity
H4J00_00380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4J00_00385	COG1960	acyl-CoA dehydrogenase activity
H4J00_00435	COG0523	cobalamin synthesis protein
H4J00_00460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H4J00_00465	COG1846	Transcriptional regulator
H4J00_00470	COG1764	response to oxidative stress
H4J00_00500	COG0656	L-ascorbic acid biosynthetic process
H4J00_00505	COG2130	NADP-dependent
H4J00_00510	COG0667	Aldo Keto reductase
H4J00_00520	COG1187	pseudouridine synthase activity
H4J00_00530	COG1643	Atp-dependent helicase
H4J00_00540	COG4807	Protein conserved in bacteria
H4J00_00545	COG2072	flavoprotein involved in K transport
H4J00_00565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H4J00_00590	COG0129	dihydroxy-acid dehydratase activity
H4J00_00600	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H4J00_00670	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H4J00_00675	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4J00_00685	COG3485	protocatechuate 3,4-dioxygenase
H4J00_00690	COG3485	protocatechuate 3,4-dioxygenase
H4J00_00705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4J00_00710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4J00_00725	COG1414	Transcriptional regulator
H4J00_00735	COG0657	acetylesterase activity
H4J00_00805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4J00_00830	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_00845	COG0156	8-amino-7-oxononanoate synthase activity
H4J00_00850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H4J00_00855	COG1040	competence protein
H4J00_00860	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H4J00_00885	COG2911	Protein conserved in bacteria
H4J00_00890	COG0729	surface antigen
H4J00_00895	COG4771	TonB-dependent receptor
H4J00_00905	COG0457	Tetratricopeptide repeat
H4J00_00915	COG0752	glycyl-tRNA synthetase alpha subunit
H4J00_00920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4J00_00930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4J00_00930	COG0519	Catalyzes the synthesis of GMP from XMP
H4J00_00940	COG0805	protein transport
H4J00_00945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4J00_00950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4J00_00960	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H4J00_00985	COG2974	May be involved in recombination
H4J00_01005	COG3661	Belongs to the glycosyl hydrolase 67 family
H4J00_01015	COG4948	Mandelate Racemase Muconate Lactonizing
H4J00_01025	COG1472	Belongs to the glycosyl hydrolase 3 family
H4J00_01030	COG0246	Mannitol dehydrogenase
H4J00_01125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4J00_01200	COG3264	Mechanosensitive ion channel
H4J00_01200	COG1511	domain protein
H4J00_01215	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H4J00_01220	COG2354	Protein conserved in bacteria
H4J00_01225	COG1649	PFAM Uncharacterised BCR, COG1649
H4J00_01245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H4J00_01270	COG0702	epimerase
H4J00_01280	COG3039	Transposase
H4J00_01285	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_01300	COG3039	Transposase
H4J00_01315	COG3039	Transposase
H4J00_01425	COG0084	hydrolase, TatD family'
H4J00_01445	COG2814	Major facilitator Superfamily
H4J00_01455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H4J00_01460	COG1902	pentaerythritol trinitrate reductase activity
H4J00_01490	COG0745	RESPONSE REGULATOR receiver
H4J00_01510	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H4J00_01515	COG0583	DNA-binding transcription factor activity
H4J00_01540	COG1733	regulation of RNA biosynthetic process
H4J00_01545	COG0702	epimerase
H4J00_01585	COG0583	DNA-binding transcription factor activity
H4J00_01625	COG1199	ATP-dependent helicase activity
H4J00_01635	COG1566	PFAM secretion protein HlyD family protein
H4J00_01655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4J00_01685	COG3228	Belongs to the MtfA family
H4J00_01695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H4J00_01695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H4J00_01700	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H4J00_01715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H4J00_01755	COG0180	Tryptophanyl-tRNA synthetase
H4J00_01760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4J00_01805	COG0753	catalase activity
H4J00_01820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H4J00_01855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4J00_01865	COG0642	Histidine kinase
H4J00_01875	COG1090	epimerase
H4J00_01905	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_01925	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H4J00_01945	COG0606	chelatase, subunit chli
H4J00_02030	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H4J00_02035	COG1166	arginine decarboxylase activity
H4J00_02055	COG2755	lipolytic protein G-D-S-L family
H4J00_02055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H4J00_02060	COG4221	oxidoreductase activity
H4J00_02085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H4J00_02110	COG0463	Glycosyl transferase, family 2
H4J00_02125	COG1475	DNA binding
H4J00_02130	COG1192	Involved in chromosome partitioning
H4J00_02160	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H4J00_02170	COG0456	acetyltransferase
H4J00_02205	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4J00_02210	COG0134	indole-3-glycerol-phosphate synthase activity
H4J00_02220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4J00_02225	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H4J00_02235	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H4J00_02245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H4J00_02315	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H4J00_02330	COG2814	Major facilitator Superfamily
H4J00_02345	COG1289	transmembrane transporter activity
H4J00_02355	COG0577	efflux transmembrane transporter activity
H4J00_02355	COG1136	(ABC) transporter
H4J00_02360	COG0151	Belongs to the GarS family
H4J00_02365	COG0138	bifunctional purine biosynthesis protein purh
H4J00_02395	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H4J00_02435	COG0439	Biotin carboxylase
H4J00_02445	COG0511	ligase activity, forming carbon-carbon bonds
H4J00_02450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H4J00_02465	COG1324	tolerance protein
H4J00_02470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H4J00_02490	COG0534	Mate efflux family protein
H4J00_02495	COG0616	signal peptide processing
H4J00_02505	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_02520	COG0009	L-threonylcarbamoyladenylate synthase
H4J00_02525	COG1754	DNA topoisomerase type I activity
H4J00_02525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4J00_02545	COG0758	DNA mediated transformation
H4J00_02555	COG0242	peptide deformylase activity
H4J00_02560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H4J00_02565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4J00_02565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H4J00_02610	COG1560	Kdo2-lipid A biosynthetic process
H4J00_02620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4J00_02660	COG0625	glutathione transferase activity
H4J00_02700	COG4555	ABC transporter
H4J00_02710	COG1476	TRANSCRIPTIONal
H4J00_02730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H4J00_02735	COG1131	(ABC) transporter
H4J00_02740	COG0842	Transport permease protein
H4J00_02750	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4J00_02770	COG3039	Transposase
H4J00_02780	COG2951	lytic endotransglycosylase activity
H4J00_02800	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_02815	COG3039	Transposase
H4J00_02900	COG2353	YceI-like domain
H4J00_02930	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H4J00_02990	COG3039	Transposase
H4J00_03035	COG1063	alcohol dehydrogenase
H4J00_03065	COG1294	oxidase, subunit
H4J00_03070	COG1271	oxidase subunit
H4J00_03105	COG2972	Histidine kinase
H4J00_03120	COG0531	amino acid
H4J00_03140	COG3590	peptidase
H4J00_03150	COG0667	Aldo Keto reductase
H4J00_03165	COG3384	dioxygenase
H4J00_03175	COG1573	uracil-dna glycosylase
H4J00_03185	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H4J00_03190	COG0025	NhaP-type Na H and K H
H4J00_03195	COG1131	(ABC) transporter
H4J00_03200	COG0842	Transport permease protein
H4J00_03215	COG1404	Belongs to the peptidase S8 family
H4J00_03230	COG0745	RESPONSE REGULATOR receiver
H4J00_03280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4J00_03305	COG2202	Pas domain
H4J00_03305	COG2205	protein histidine kinase activity
H4J00_03335	COG2813	Specifically methylates the guanine in position
H4J00_03340	COG1187	pseudouridine synthase activity
H4J00_03345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4J00_03380	COG0697	spore germination
H4J00_03390	COG2011	ABC-type metal ion transport system permease component
H4J00_03425	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4J00_03435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4J00_03455	COG0356	it plays a direct role in the translocation of protons across the membrane
H4J00_03465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H4J00_03475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H4J00_03480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H4J00_03485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H4J00_03510	COG4191	Histidine kinase
H4J00_03520	COG0577	efflux transmembrane transporter activity
H4J00_03520	COG1136	(ABC) transporter
H4J00_03525	COG1136	(ABC) transporter
H4J00_03525	COG0577	efflux transmembrane transporter activity
H4J00_03540	COG1136	(ABC) transporter
H4J00_03545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4J00_03550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4J00_03600	COG0339	signal peptide processing
H4J00_03625	COG0546	phosphoglycolate phosphatase activity
H4J00_03635	COG1956	GAF domain-containing protein
H4J00_03640	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H4J00_03650	COG0720	synthase
H4J00_03655	COG0513	Belongs to the DEAD box helicase family
H4J00_03665	COG0625	glutathione transferase activity
H4J00_03695	COG0626	cystathionine gamma-synthase activity
H4J00_03710	COG0110	maltose O-acetyltransferase activity
H4J00_03715	COG0438	transferase activity, transferring glycosyl groups
H4J00_03715	COG1216	Glycosyl transferase, family 2
H4J00_03720	COG3754	Rhamnan synthesis protein F
H4J00_03730	COG2226	methyltransferase
H4J00_03750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4J00_03765	COG0277	FAD linked oxidase domain protein
H4J00_03770	COG0546	phosphoglycolate phosphatase activity
H4J00_03770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H4J00_03785	COG2086	electron transfer activity
H4J00_03810	COG0662	Cupin 2, conserved barrel domain protein
H4J00_03810	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H4J00_03815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4J00_03850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4J00_03850	COG3218	ABC-type transport auxiliary lipoprotein component
H4J00_03855	COG1127	ABC transporter
H4J00_03860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4J00_03875	COG0442	prolyl-tRNA aminoacylation
H4J00_03885	COG1183	phosphatidylcholine synthase activity
H4J00_03915	COG0525	valine-tRNA ligase activity
H4J00_03930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H4J00_03940	COG0795	lipopolysaccharide-transporting ATPase activity
H4J00_03955	COG4974	Belongs to the 'phage' integrase family
H4J00_03960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4J00_03965	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H4J00_03965	COG0047	phosphoribosylformylglycinamidine synthase activity
H4J00_03970	COG5295	Hep Hag repeat protein
H4J00_03975	COG1404	Belongs to the peptidase S8 family
H4J00_03980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4J00_03990	COG1459	type II secretion system
H4J00_03995	COG2165	general secretion pathway protein
H4J00_04000	COG4970	Tfp pilus assembly protein FimT
H4J00_04005	COG2165	general secretion pathway protein
H4J00_04010	COG4795	General secretion pathway protein
H4J00_04015	COG3156	type II secretion system protein K
H4J00_04020	COG3166	PFAM Fimbrial assembly family protein
H4J00_04035	COG1450	Type ii and iii secretion system protein
H4J00_04050	COG2188	Transcriptional regulator
H4J00_04100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H4J00_04110	COG3039	Transposase
H4J00_04130	COG0242	peptide deformylase activity
H4J00_04165	COG0402	S-adenosylhomocysteine deaminase activity
H4J00_04170	COG3964	amidohydrolase
H4J00_04190	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H4J00_04195	COG0726	polysaccharide deacetylase
H4J00_04215	COG0436	Aminotransferase
H4J00_04245	COG2211	Major facilitator Superfamily
H4J00_04255	COG1609	Transcriptional regulator
H4J00_04260	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_04265	COG2851	Citrate transporter
H4J00_04280	COG0642	Histidine kinase
H4J00_04290	COG2197	response regulator
H4J00_04305	COG0583	DNA-binding transcription factor activity
H4J00_04320	COG4191	Histidine kinase
H4J00_04335	COG0281	malic enzyme
H4J00_04335	COG0280	phosphate acetyltransferase
H4J00_04360	COG1560	Kdo2-lipid A biosynthetic process
H4J00_04365	COG1519	Transferase
H4J00_04370	COG3039	Transposase
H4J00_04375	COG1538	Outer membrane efflux protein
H4J00_04380	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4J00_04400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4J00_04405	COG0066	3-isopropylmalate dehydratase activity
H4J00_04410	COG2226	methyltransferase
H4J00_04440	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H4J00_04450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H4J00_04455	COG3710	Transcriptional regulator
H4J00_04480	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H4J00_04490	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H4J00_04525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4J00_04535	COG3781	membrane
H4J00_04555	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_04575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4J00_04580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4J00_04635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H4J00_04645	COG0352	thiamine-phosphate diphosphorylase activity
H4J00_04650	COG1773	rubredoxin
H4J00_04655	COG2912	Transglutaminase-like superfamily
H4J00_04675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H4J00_04700	COG0006	proline dipeptidase activity
H4J00_04730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4J00_04740	COG0346	lactoylglutathione lyase activity
H4J00_04745	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H4J00_04750	COG1561	YicC-like family, N-terminal region
H4J00_04770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4J00_04780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4J00_04810	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H4J00_04845	COG0714	Associated with various cellular activities
H4J00_04865	COG2304	oxidoreductase activity
H4J00_04900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H4J00_05000	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H4J00_05005	COG4149	molybdate abc transporter
H4J00_05010	COG0725	ABC transporter, periplasmic molybdate-binding protein
H4J00_05015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4J00_05015	COG3453	Protein conserved in bacteria
H4J00_05025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4J00_05040	COG0126	phosphoglycerate kinase activity
H4J00_05050	COG0469	pyruvate kinase activity
H4J00_05055	COG3588	fructose-bisphosphate aldolase
H4J00_05060	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H4J00_05075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H4J00_05075	COG1648	precorrin-2 dehydrogenase activity
H4J00_05100	COG2205	protein histidine kinase activity
H4J00_05100	COG0784	Response regulator, receiver
H4J00_05100	COG2198	Histidine kinase
H4J00_05120	COG0175	sulfate reduction
H4J00_05125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4J00_05130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H4J00_05135	COG0175	sulfate reduction
H4J00_05140	COG0529	Catalyzes the synthesis of activated sulfate
H4J00_05140	COG2895	sulfate adenylyltransferase (ATP) activity
H4J00_05150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4J00_05155	COG0308	aminopeptidase N
H4J00_05180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4J00_05205	COG1970	mechanosensitive ion channel activity
H4J00_05230	COG0471	metal ion transport
H4J00_05230	COG3273	potassium ion transport
H4J00_05240	COG2022	thiamine diphosphate biosynthetic process
H4J00_05260	COG3039	Transposase
H4J00_05280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H4J00_05290	COG2003	Belongs to the UPF0758 family
H4J00_05325	COG0084	hydrolase, TatD family'
H4J00_05345	COG3039	Transposase
H4J00_05400	COG0745	RESPONSE REGULATOR receiver
H4J00_05430	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H4J00_05440	COG4969	Belongs to the N-Me-Phe pilin family
H4J00_05445	COG2194	sulfuric ester hydrolase activity
H4J00_05485	COG0045	succinate-CoA ligase (ADP-forming) activity
H4J00_05490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H4J00_05505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H4J00_05505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4J00_05510	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4J00_05515	COG0564	pseudouridine synthase activity
H4J00_05530	COG3011	Protein conserved in bacteria
H4J00_05535	COG0840	transmembrane signaling receptor activity
H4J00_05550	COG3387	PFAM Glycoside hydrolase 15-related
H4J00_05555	COG1877	trehalose-phosphatase activity
H4J00_05595	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H4J00_05610	COG1595	DNA-templated transcription, initiation
H4J00_05620	COG1946	Acyl-CoA thioesterase
H4J00_05635	COG0824	Thioesterase
H4J00_05640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H4J00_05650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H4J00_05655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H4J00_05660	COG0268	Binds directly to 16S ribosomal RNA
H4J00_05665	COG0728	peptidoglycan biosynthetic process
H4J00_05670	COG0196	riboflavin kinase activity
H4J00_05680	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H4J00_05685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H4J00_05700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4J00_05705	COG1845	cytochrome c oxidase, subunit III
H4J00_05710	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H4J00_05765	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_05775	COG3039	Transposase
H4J00_05815	COG2207	Transcriptional regulator
H4J00_05820	COG0326	Molecular chaperone. Has ATPase activity
H4J00_05830	COG1366	Belongs to the anti-sigma-factor antagonist family
H4J00_05835	COG1366	Belongs to the anti-sigma-factor antagonist family
H4J00_05840	COG2172	sigma factor antagonist activity
H4J00_05880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4J00_05885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H4J00_05895	COG2070	2-Nitropropane dioxygenase
H4J00_05905	COG0228	four-way junction DNA binding
H4J00_05910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H4J00_05915	COG0336	Belongs to the RNA methyltransferase TrmD family
H4J00_05930	COG0534	Mate efflux family protein
H4J00_05940	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H4J00_05965	COG0542	response to heat
H4J00_06020	COG0019	diaminopimelate decarboxylase activity
H4J00_06030	COG2814	Major facilitator Superfamily
H4J00_06035	COG4264	IucA IucC family
H4J00_06045	COG4772	TonB-dependent receptor
H4J00_06060	COG4651	solute:proton antiporter activity
H4J00_06060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4J00_06090	COG0488	(ABC) transporter
H4J00_06115	COG0657	acetylesterase activity
H4J00_06115	COG2755	lipolytic protein G-D-S-L family
H4J00_06130	COG0477	Major facilitator Superfamily
H4J00_06145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H4J00_06180	COG2255	four-way junction helicase activity
H4J00_06185	COG0824	Thioesterase
H4J00_06205	COG0823	Involved in the tonB-independent uptake of proteins
H4J00_06210	COG2885	chlorophyll binding
H4J00_06220	COG0602	queuosine metabolic process
H4J00_06230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4J00_06270	COG4695	Portal protein
H4J00_06315	COG3179	chitinase
H4J00_06490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H4J00_06520	COG1187	pseudouridine synthase activity
H4J00_06535	COG0514	ATP-dependent DNA helicase (RecQ)
H4J00_06540	COG0783	Belongs to the Dps family
H4J00_06545	COG1643	Atp-dependent helicase
H4J00_06600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4J00_06610	COG1215	transferase activity, transferring glycosyl groups
H4J00_06615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4J00_06625	COG1199	ATP-dependent helicase activity
H4J00_06645	COG0189	ligase activity
H4J00_06660	COG0835	chemotaxis
H4J00_06665	COG0840	transmembrane signaling receptor activity
H4J00_06670	COG0643	Histidine kinase
H4J00_06670	COG0784	Response regulator, receiver
H4J00_06670	COG2198	Histidine kinase
H4J00_06695	COG2304	oxidoreductase activity
H4J00_06700	COG1446	asparaginase
H4J00_06745	COG3537	Alpha-1,2-mannosidase
H4J00_06760	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_06775	COG1472	Belongs to the glycosyl hydrolase 3 family
H4J00_06785	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H4J00_06790	COG3858	chitin binding
H4J00_06790	COG1388	LysM domain
H4J00_06805	COG0837	glucose binding
H4J00_06810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4J00_06820	COG0494	nUDIX hydrolase
H4J00_06830	COG3956	TIGRFAM MazG family protein
H4J00_06835	COG1742	UPF0060 membrane protein
H4J00_06845	COG0330	HflC and HflK could
H4J00_06860	COG0509	glycine decarboxylation via glycine cleavage system
H4J00_06895	COG1960	acyl-CoA dehydrogenase activity
H4J00_06905	COG1309	transcriptional regulator
H4J00_06910	COG4771	TonB-dependent receptor
H4J00_06920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H4J00_06930	COG0463	Glycosyl transferase, family 2
H4J00_06935	COG0516	GMP reductase activity
H4J00_06935	COG0517	IMP dehydrogenase activity
H4J00_06945	COG1272	protein, Hemolysin III
H4J00_06955	COG0739	heme binding
H4J00_06960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4J00_06965	COG0626	cystathionine gamma-synthase activity
H4J00_06975	COG1760	l-serine dehydratase
H4J00_07000	COG2353	YceI-like domain
H4J00_07005	COG2205	protein histidine kinase activity
H4J00_07005	COG2198	Histidine kinase
H4J00_07005	COG0784	Response regulator, receiver
H4J00_07010	COG0784	Response regulator, receiver
H4J00_07010	COG5002	protein histidine kinase activity
H4J00_07050	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H4J00_07070	COG1960	acyl-CoA dehydrogenase activity
H4J00_07095	COG1024	Enoyl-CoA hydratase
H4J00_07095	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4J00_07110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4J00_07115	COG0481	GTPase activity
H4J00_07120	COG0681	Belongs to the peptidase S26 family
H4J00_07140	COG1381	Involved in DNA repair and RecF pathway recombination
H4J00_07155	COG2954	triphosphatase activity
H4J00_07160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4J00_07165	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H4J00_07170	COG3046	protein related to deoxyribodipyrimidine photolyase
H4J00_07180	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H4J00_07185	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H4J00_07190	COG1278	Cold shock
H4J00_07210	COG1201	RNA secondary structure unwinding
H4J00_07215	COG1793	dna ligase
H4J00_07225	COG1793	dna ligase
H4J00_07225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H4J00_07240	COG3706	GGDEF domain
H4J00_07255	COG0183	Belongs to the thiolase family
H4J00_07275	COG1451	nucleotide metabolic process
H4J00_07290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H4J00_07330	COG1047	Peptidyl-prolyl cis-trans
H4J00_07340	COG2824	Alkylphosphonate utilization operon protein PhnA
H4J00_07350	COG1902	pentaerythritol trinitrate reductase activity
H4J00_07355	COG2814	Major facilitator Superfamily
H4J00_07390	COG0392	lysyltransferase activity
H4J00_07390	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H4J00_07400	COG0251	oxidation-reduction process
H4J00_07405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4J00_07420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4J00_07445	COG1595	DNA-templated transcription, initiation
H4J00_07460	COG2878	Part of a membrane complex involved in electron transport
H4J00_07470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4J00_07470	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4J00_07480	COG0346	lactoylglutathione lyase activity
H4J00_07485	COG0833	amino acid
H4J00_07490	COG2040	homocysteine
H4J00_07505	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H4J00_07525	COG1695	Transcriptional regulator
H4J00_07550	COG1981	membrane
H4J00_07575	COG0825	malonyl-CoA metabolic process
H4J00_07595	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4J00_07600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H4J00_07605	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4J00_07610	COG3039	Transposase
H4J00_07620	COG0750	zinc metalloprotease
H4J00_07625	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H4J00_07630	COG0575	Belongs to the CDS family
H4J00_07640	COG0233	cytoplasmic translational termination
H4J00_07655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H4J00_07715	COG1393	Belongs to the ArsC family
H4J00_07725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4J00_07730	COG0367	asparagine synthase
H4J00_07740	COG4774	siderophore transport
H4J00_07760	COG2207	Transcriptional regulator
H4J00_07775	COG1566	PFAM secretion protein HlyD family protein
H4J00_07780	COG2814	Major facilitator Superfamily
H4J00_07885	COG0386	Belongs to the glutathione peroxidase family
H4J00_07950	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H4J00_07955	COG0084	hydrolase, TatD family'
H4J00_07970	COG1960	acyl-CoA dehydrogenase activity
H4J00_07985	COG0367	asparagine synthase
H4J00_07995	COG0305	Participates in initiation and elongation during chromosome replication
H4J00_08000	COG0415	Belongs to the DNA photolyase family
H4J00_08015	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_08035	COG3706	GGDEF domain
H4J00_08050	COG0489	protein tyrosine kinase activity
H4J00_08055	COG0717	Belongs to the dCTP deaminase family
H4J00_08080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4J00_08095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4J00_08115	COG0433	COG0433 Predicted ATPase
H4J00_08140	COG2890	protein-(glutamine-N5) methyltransferase activity
H4J00_08145	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H4J00_08150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4J00_08155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H4J00_08175	COG0101	tRNA pseudouridine synthase activity
H4J00_08180	COG0135	phosphoribosylanthranilate isomerase activity
H4J00_08190	COG0133	tryptophan synthase activity
H4J00_08205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H4J00_08210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4J00_08250	COG0149	triose-phosphate isomerase activity
H4J00_08265	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4J00_08275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4J00_08280	COG0649	NAD binding
H4J00_08285	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H4J00_08290	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H4J00_08295	COG1034	ATP synthesis coupled electron transport
H4J00_08300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H4J00_08330	COG1007	ATP synthesis coupled electron transport
H4J00_08340	COG0779	Required for maturation of 30S ribosomal subunits
H4J00_08345	COG0195	Participates in both transcription termination and antitermination
H4J00_08350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H4J00_08365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H4J00_08370	COG1185	polyribonucleotide nucleotidyltransferase activity
H4J00_08405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H4J00_08415	COG2095	MarC family integral membrane protein
H4J00_08430	COG1611	Belongs to the LOG family
H4J00_08525	COG4974	Belongs to the 'phage' integrase family
H4J00_08530	COG4969	Belongs to the N-Me-Phe pilin family
H4J00_08535	COG0556	nucleotide-excision repair
H4J00_08570	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H4J00_08580	COG2986	histidine ammonia-lyase
H4J00_08585	COG1228	amidohydrolase
H4J00_08625	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4J00_08630	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H4J00_08635	COG1605	Chorismate mutase
H4J00_08635	COG0077	Prephenate dehydratase
H4J00_08640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H4J00_08660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H4J00_08665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H4J00_08670	COG0583	DNA-binding transcription factor activity
H4J00_08705	COG3039	Transposase
H4J00_08735	COG0840	transmembrane signaling receptor activity
H4J00_08750	COG0784	Response regulator, receiver
H4J00_08750	COG2205	protein histidine kinase activity
H4J00_08750	COG5002	protein histidine kinase activity
H4J00_08755	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H4J00_08765	COG0784	Response regulator, receiver
H4J00_08765	COG4191	Histidine kinase
H4J00_08785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4J00_08805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4J00_08820	COG1595	DNA-templated transcription, initiation
H4J00_08870	COG2244	polysaccharide biosynthetic process
H4J00_08900	COG2264	protein methyltransferase activity
H4J00_08910	COG0438	transferase activity, transferring glycosyl groups
H4J00_08930	COG1132	(ABC) transporter
H4J00_08940	COG0477	Major facilitator Superfamily
H4J00_08950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4J00_08965	COG1253	flavin adenine dinucleotide binding
H4J00_09000	COG0504	CTP synthase activity
H4J00_09005	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H4J00_09015	COG0148	phosphopyruvate hydratase activity
H4J00_09020	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H4J00_09035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H4J00_09050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H4J00_09055	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4J00_09060	COG1238	metal cluster binding
H4J00_09075	COG1534	Rna-binding protein
H4J00_09080	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H4J00_09090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H4J00_09105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4J00_09110	COG1546	Belongs to the CinA family
H4J00_09125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H4J00_09130	COG2137	regulation of response to DNA damage stimulus
H4J00_09135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H4J00_09140	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H4J00_09155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H4J00_09180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H4J00_09205	COG2166	iron-sulfur cluster assembly
H4J00_09220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H4J00_09225	COG0137	argininosuccinate synthase activity
H4J00_09235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4J00_09240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H4J00_09255	COG0165	Argininosuccinate lyase
H4J00_09305	COG1271	oxidase subunit
H4J00_09315	COG4988	ABC transporter
H4J00_09320	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H4J00_09380	COG4133	protoheme IX ABC transporter activity
H4J00_09385	COG0436	Aminotransferase
H4J00_09405	COG1187	pseudouridine synthase activity
H4J00_09410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H4J00_09415	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H4J00_09420	COG2350	Protein conserved in bacteria
H4J00_09450	COG1175	transmembrane transport
H4J00_09455	COG0395	ABC-type sugar transport system, permease component
H4J00_09480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4J00_09490	COG2957	Belongs to the agmatine deiminase family
H4J00_09505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H4J00_09510	COG0539	negative regulation of cytoplasmic translation
H4J00_09515	COG0776	regulation of translation
H4J00_09525	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H4J00_09530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4J00_09540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4J00_09555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H4J00_09565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4J00_09565	COG0519	Catalyzes the synthesis of GMP from XMP
H4J00_09570	COG3002	Belongs to the UPF0753 family
H4J00_09575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4J00_09580	COG0583	DNA-binding transcription factor activity
H4J00_09605	COG0583	DNA-binding transcription factor activity
H4J00_09610	COG0583	DNA-binding transcription factor activity
H4J00_09625	COG2201	protein-glutamate methylesterase activity
H4J00_09630	COG1914	H( )-stimulated, divalent metal cation uptake system
H4J00_09650	COG0668	transmembrane transport
H4J00_09675	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_09680	COG1183	phosphatidylcholine synthase activity
H4J00_09690	COG3243	poly(R)-hydroxyalkanoic acid synthase
H4J00_09705	COG0723	plastoquinol--plastocyanin reductase activity
H4J00_09705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4J00_09715	COG2183	response to ionizing radiation
H4J00_09725	COG0784	Response regulator, receiver
H4J00_09725	COG2205	protein histidine kinase activity
H4J00_09840	COG3039	Transposase
H4J00_09845	COG0800	Aldolase
H4J00_09850	COG0129	dihydroxy-acid dehydratase activity
H4J00_09855	COG0363	glucosamine-6-phosphate deaminase activity
H4J00_09865	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H4J00_09880	COG0354	folic acid binding
H4J00_09895	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H4J00_09910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4J00_09925	COG4591	ABC-type transport system involved in lipoprotein release permease component
H4J00_09950	COG0811	peptide transport
H4J00_09965	COG1663	tetraacyldisaccharide 4'-kinase activity
H4J00_09975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4J00_09985	COG0322	excinuclease ABC activity
H4J00_10015	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_10040	COG3039	Transposase
H4J00_10080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H4J00_10100	COG1054	Belongs to the UPF0176 family
H4J00_10110	COG1530	ribonuclease E activity
H4J00_10120	COG3064	Membrane
H4J00_10140	COG2154	pterin-4-alpha-carbinolamine dehydratase
H4J00_10300	COG0631	protein serine/threonine phosphatase activity
H4J00_10305	COG0515	serine threonine protein kinase
H4J00_10335	COG1858	cytochrome C peroxidase
H4J00_10385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4J00_10390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4J00_10495	COG2201	protein-glutamate methylesterase activity
H4J00_10535	COG4566	intracellular signal transduction
H4J00_10545	COG5001	Diguanylate cyclase
H4J00_10595	COG1648	precorrin-2 dehydrogenase activity
H4J00_10595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H4J00_10620	COG0746	molybdenum cofactor guanylyltransferase activity
H4J00_10650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H4J00_10665	COG0303	'Molybdopterin
H4J00_10670	COG1160	GTP binding
H4J00_10675	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4J00_10695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H4J00_10710	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4J00_10710	COG1024	Enoyl-CoA hydratase
H4J00_10715	COG0183	Belongs to the thiolase family
H4J00_10720	COG0038	chloride channel
H4J00_10740	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H4J00_10760	COG1674	ftsk spoiiie
H4J00_10765	COG0492	ferredoxin-NADP+ reductase activity
H4J00_10790	COG0542	response to heat
H4J00_10805	COG0482	sulfurtransferase activity
H4J00_10835	COG4585	Histidine kinase
H4J00_10845	COG4191	Histidine kinase
H4J00_10865	COG0784	Response regulator, receiver
H4J00_10865	COG0835	chemotaxis
H4J00_10875	COG1558	bacterial-type flagellum-dependent cell motility
H4J00_10880	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H4J00_10890	COG4787	bacterial-type flagellum-dependent cell motility
H4J00_10910	COG1705	Flagellar rod assembly protein muramidase FlgJ
H4J00_10910	COG3951	Flagellar rod assembly protein muramidase FlgJ
H4J00_10925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H4J00_10930	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H4J00_10960	COG2201	protein-glutamate methylesterase activity
H4J00_10980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4J00_10985	COG4221	oxidoreductase activity
H4J00_10990	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_11025	COG1677	Flagellar hook-basal body complex protein FliE
H4J00_11075	COG3190	flagellar
H4J00_11090	COG1684	flagellar biosynthetic protein fliR
H4J00_11145	COG0784	Response regulator, receiver
H4J00_11145	COG0643	Histidine kinase
H4J00_11145	COG2198	Histidine kinase
H4J00_11245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H4J00_11250	COG1360	Flagellar Motor Protein
H4J00_11255	COG1192	Involved in chromosome partitioning
H4J00_11260	COG0835	chemotaxis
H4J00_11270	COG0745	RESPONSE REGULATOR receiver
H4J00_11280	COG0840	transmembrane signaling receptor activity
H4J00_11305	COG0840	transmembrane signaling receptor activity
H4J00_11310	COG0840	transmembrane signaling receptor activity
H4J00_11315	COG0840	transmembrane signaling receptor activity
H4J00_11325	COG0840	transmembrane signaling receptor activity
H4J00_11330	COG0840	transmembrane signaling receptor activity
H4J00_11335	COG0840	transmembrane signaling receptor activity
H4J00_11340	COG0840	transmembrane signaling receptor activity
H4J00_11345	COG0840	transmembrane signaling receptor activity
H4J00_11360	COG0835	chemotaxis
H4J00_11370	COG0840	transmembrane signaling receptor activity
H4J00_11400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4J00_11430	COG0318	PFAM AMP-dependent synthetase and ligase
H4J00_11435	COG1024	Enoyl-CoA hydratase
H4J00_11440	COG2198	Histidine kinase
H4J00_11440	COG2205	protein histidine kinase activity
H4J00_11440	COG0784	Response regulator, receiver
H4J00_11460	COG3279	Response regulator of the LytR AlgR family
H4J00_11475	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H4J00_11485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4J00_11490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H4J00_11500	COG0505	Belongs to the CarA family
H4J00_11505	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H4J00_11510	COG2258	MOSC domain
H4J00_11515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4J00_11565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H4J00_11585	COG0277	FAD linked oxidase domain protein
H4J00_11590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4J00_11600	COG0531	amino acid
H4J00_11605	COG0531	amino acid
H4J00_11610	COG0235	Class ii aldolase
H4J00_11615	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H4J00_11635	COG0140	phosphoribosyl-ATP diphosphatase activity
H4J00_11635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H4J00_11645	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H4J00_11655	COG0131	Imidazoleglycerol-phosphate dehydratase
H4J00_11655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H4J00_11670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H4J00_11685	COG0124	histidyl-tRNA synthetase
H4J00_11700	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H4J00_11715	COG2801	Transposase and inactivated derivatives
H4J00_11755	COG1012	belongs to the aldehyde dehydrogenase family
H4J00_11775	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H4J00_11780	COG0697	spore germination
H4J00_11785	COG1794	racemase activity, acting on amino acids and derivatives
H4J00_11800	COG0671	phosphoesterase, PA-phosphatase related
H4J00_11815	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H4J00_11820	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H4J00_11830	COG5001	Diguanylate cyclase
H4J00_11830	COG2203	Gaf domain
H4J00_11830	COG3706	GGDEF domain
H4J00_11830	COG4251	negative regulation of phosphorylation
H4J00_11845	COG1472	Belongs to the glycosyl hydrolase 3 family
H4J00_11870	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H4J00_11890	COG0617	tRNA 3'-terminal CCA addition
H4J00_11900	COG1469	GTP cyclohydrolase I activity
H4J00_11905	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4J00_11915	COG0477	Major facilitator Superfamily
H4J00_11925	COG1070	Carbohydrate kinase
H4J00_11950	COG0800	Aldolase
H4J00_11955	COG4948	Mandelate Racemase Muconate Lactonizing
H4J00_11965	COG3734	2-keto-3-deoxy-galactonokinase
H4J00_11970	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H4J00_11980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4J00_11995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H4J00_12000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H4J00_12010	COG0352	thiamine-phosphate diphosphorylase activity
H4J00_12010	COG0351	phosphomethylpyrimidine kinase
H4J00_12035	COG0583	DNA-binding transcription factor activity
H4J00_12040	COG1741	Belongs to the pirin family
H4J00_12085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4J00_12090	COG0402	S-adenosylhomocysteine deaminase activity
H4J00_12105	COG1509	lysine 2,3-aminomutase activity
H4J00_12110	COG5001	Diguanylate cyclase
H4J00_12110	COG3300	MHYT domain
H4J00_12125	COG0483	inositol monophosphate 1-phosphatase activity
H4J00_12130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4J00_12155	COG0488	(ABC) transporter
H4J00_12160	COG0513	Belongs to the DEAD box helicase family
H4J00_12170	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H4J00_12180	COG0625	glutathione transferase activity
H4J00_12185	COG1278	Cold shock
H4J00_12190	COG1671	Belongs to the UPF0178 family
H4J00_12195	COG4681	YaeQ
H4J00_12200	COG2081	HI0933 family
H4J00_12220	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_12240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H4J00_12245	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4J00_12250	COG0802	atpase or kinase
H4J00_12255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H4J00_12255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H4J00_12260	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H4J00_12280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4J00_12350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H4J00_12445	COG2801	Transposase and inactivated derivatives
H4J00_12460	COG0835	chemotaxis
H4J00_12465	COG0840	transmembrane signaling receptor activity
H4J00_12490	COG2969	positive regulation of protein catabolic process
H4J00_12495	COG0625	glutathione transferase activity
H4J00_12500	COG2857	Cytochrome c1
H4J00_12505	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H4J00_12510	COG0723	plastoquinol--plastocyanin reductase activity
H4J00_12515	COG0741	lytic transglycosylase activity
H4J00_12540	COG1702	phosphate starvation-inducible protein PhoH
H4J00_12560	COG4535	Mg2 and Co2 transporter CorC
H4J00_12575	COG1012	belongs to the aldehyde dehydrogenase family
H4J00_12580	COG1177	transmembrane transport
H4J00_12585	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4J00_12595	COG3842	ATPase activity
H4J00_12615	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H4J00_12650	COG2201	protein-glutamate methylesterase activity
H4J00_12710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H4J00_12715	COG0174	glutamine synthetase
H4J00_12720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4J00_12730	COG0477	Major facilitator Superfamily
H4J00_12740	COG0243	molybdopterin cofactor binding
H4J00_12760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4J00_12765	COG1121	(ABC) transporter
H4J00_12775	COG2733	membrane
H4J00_12780	COG0784	Response regulator, receiver
H4J00_12780	COG2205	protein histidine kinase activity
H4J00_12780	COG5002	protein histidine kinase activity
H4J00_12795	COG0477	Major facilitator Superfamily
H4J00_12805	COG2902	Dehydrogenase
H4J00_12815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4J00_12820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4J00_12830	COG1609	Transcriptional regulator
H4J00_12835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4J00_12835	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4J00_12840	COG1105	Belongs to the carbohydrate kinase PfkB family
H4J00_12845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4J00_12845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4J00_12855	COG3039	Transposase
H4J00_12895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4J00_12905	COG1862	Preprotein translocase
H4J00_12910	COG0343	queuine tRNA-ribosyltransferase activity
H4J00_12965	COG0405	Gamma-glutamyltransferase
H4J00_12970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4J00_12980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H4J00_12985	COG0742	ribosomal rna small subunit methyltransferase
H4J00_12990	COG0326	Molecular chaperone. Has ATPase activity
H4J00_13030	COG4206	TonB-dependent receptor
H4J00_13080	COG0531	amino acid
H4J00_13095	COG0006	proline dipeptidase activity
H4J00_13105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4J00_13120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4J00_13125	COG3938	Belongs to the proline racemase family
H4J00_13135	COG0552	protein localization to endoplasmic reticulum
H4J00_13145	COG1194	a g-specific adenine glycosylase
H4J00_13155	COG0784	Response regulator, receiver
H4J00_13155	COG4191	Histidine kinase
H4J00_13160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4J00_13180	COG3040	lipid binding
H4J00_13190	COG1960	acyl-CoA dehydrogenase activity
H4J00_13200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H4J00_13230	COG0438	transferase activity, transferring glycosyl groups
H4J00_13240	COG0438	transferase activity, transferring glycosyl groups
H4J00_13245	COG0438	transferase activity, transferring glycosyl groups
H4J00_13300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H4J00_13315	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H4J00_13325	COG2963	transposase activity
H4J00_13340	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H4J00_13355	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H4J00_13375	COG3115	cell septum assembly
H4J00_13395	COG0360	Binds together with S18 to 16S ribosomal RNA
H4J00_13400	COG0316	Belongs to the HesB IscA family
H4J00_13430	COG0288	reversible hydration of carbon dioxide
H4J00_13445	COG3844	kynureninase activity
H4J00_13455	COG2925	Exonuclease
H4J00_13465	COG0667	Aldo Keto reductase
H4J00_13490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H4J00_13490	COG0116	Belongs to the methyltransferase superfamily
H4J00_13535	COG0494	nUDIX hydrolase
H4J00_13545	COG1024	Enoyl-CoA hydratase
H4J00_13555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H4J00_13585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H4J00_13590	COG0573	inorganic phosphate transmembrane transporter activity
H4J00_13605	COG0704	Plays a role in the regulation of phosphate uptake
H4J00_13615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4J00_13625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4J00_13640	COG0557	exoribonuclease II activity
H4J00_13665	COG1960	acyl-CoA dehydrogenase activity
H4J00_13670	COG2226	methyltransferase
H4J00_13690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4J00_13700	COG1609	Transcriptional regulator
H4J00_13715	COG2900	Belongs to the SlyX family
H4J00_13730	COG0386	Belongs to the glutathione peroxidase family
H4J00_13740	COG1725	Transcriptional regulator
H4J00_13745	COG1131	(ABC) transporter
H4J00_13805	COG2850	peptidyl-arginine hydroxylation
H4J00_13845	COG1132	(ABC) transporter
H4J00_13855	COG0583	DNA-binding transcription factor activity
H4J00_13880	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H4J00_13885	COG0484	heat shock protein binding
H4J00_13890	COG0443	Heat shock 70 kDa protein
H4J00_13895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H4J00_13905	COG0497	DNA recombination
H4J00_13915	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4J00_13920	COG2914	Belongs to the UPF0125 (RnfH) family
H4J00_13930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H4J00_14010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4J00_14015	COG2311	Membrane
H4J00_14020	COG1047	Peptidyl-prolyl cis-trans
H4J00_14025	COG0791	NLP P60 protein
H4J00_14030	COG0791	NLP P60 protein
H4J00_14045	COG4106	trans-aconitate 2-methyltransferase activity
H4J00_14050	COG1301	dicarboxylic acid transport
H4J00_14055	COG1785	Belongs to the alkaline phosphatase family
H4J00_14060	COG0037	tRNA processing
H4J00_14065	COG1722	exodeoxyribonuclease VII activity
H4J00_14070	COG0142	geranyltranstransferase activity
H4J00_14075	COG4104	PAAR repeat-containing protein
H4J00_14095	COG0312	modulator of DNA gyrase
H4J00_14100	COG3028	Belongs to the UPF0307 family
H4J00_14105	COG0312	modulator of DNA gyrase
H4J00_14115	COG3164	Protein of unknown function
H4J00_14130	COG2968	Membrane
H4J00_14155	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H4J00_14175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H4J00_14200	COG3118	belongs to the thioredoxin family
H4J00_14265	COG1132	(ABC) transporter
H4J00_14295	COG0745	RESPONSE REGULATOR receiver
H4J00_14300	COG5000	phosphorelay sensor kinase activity
H4J00_14300	COG5002	protein histidine kinase activity
H4J00_14305	COG0475	glutathione-regulated potassium exporter activity
H4J00_14315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4J00_14335	COG1187	pseudouridine synthase activity
H4J00_14340	COG5001	Diguanylate cyclase
H4J00_14340	COG5002	protein histidine kinase activity
H4J00_14390	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H4J00_14465	COG0735	belongs to the Fur family
H4J00_14470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4J00_14500	COG2205	protein histidine kinase activity
H4J00_14510	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H4J00_14520	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H4J00_14535	COG0643	Histidine kinase
H4J00_14535	COG2198	Histidine kinase
H4J00_14540	COG0840	transmembrane signaling receptor activity
H4J00_14545	COG0835	chemotaxis
H4J00_14550	COG2202	Pas domain
H4J00_14550	COG2200	EAL domain
H4J00_14550	COG2199	diguanylate cyclase activity
H4J00_14555	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H4J00_14590	COG2201	protein-glutamate methylesterase activity
H4J00_14635	COG1515	deoxyribonuclease V activity
H4J00_14645	COG1741	Belongs to the pirin family
H4J00_14745	COG1741	Belongs to the pirin family
H4J00_14750	COG1966	Carbon starvation protein
H4J00_14755	COG2879	small protein
H4J00_14805	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H4J00_14810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4J00_14815	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H4J00_14820	COG2080	2 iron, 2 sulfur cluster binding
H4J00_14830	COG5001	Diguanylate cyclase
H4J00_14830	COG2203	Gaf domain
H4J00_14830	COG4251	negative regulation of phosphorylation
H4J00_14830	COG3706	GGDEF domain
H4J00_14835	COG0629	single-stranded DNA binding
H4J00_14840	COG0142	geranyltranstransferase activity
H4J00_14865	COG0527	aspartate kinase activity
H4J00_14875	COG0384	phenazine biosynthesis protein PhzF
H4J00_14885	COG1764	response to oxidative stress
H4J00_14900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H4J00_14905	COG1678	Uncharacterized ACR, COG1678
H4J00_14915	COG0519	Catalyzes the synthesis of GMP from XMP
H4J00_14945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H4J00_15000	COG1959	2 iron, 2 sulfur cluster binding
H4J00_15005	COG0719	Fe-S assembly protein
H4J00_15010	COG0396	ATPase activity
H4J00_15015	COG0719	Fe-S assembly protein
H4J00_15020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4J00_15030	COG2146	nitrite reductase [NAD(P)H] activity
H4J00_15045	COG1555	photosystem II stabilization
H4J00_15050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4J00_15065	COG3178	'Phosphotransferase
H4J00_15070	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4J00_15080	COG0628	permease
H4J00_15090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H4J00_15105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H4J00_15125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4J00_15130	COG0271	Belongs to the BolA IbaG family
H4J00_15140	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H4J00_15150	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H4J00_15155	COG1137	ATPase activity
H4J00_15170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4J00_15180	COG1660	Displays ATPase and GTPase activities
H4J00_15190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4J00_15195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4J00_15200	COG2239	Acts as a magnesium transporter
H4J00_15210	COG1294	oxidase, subunit
H4J00_15215	COG1271	oxidase subunit
H4J00_15225	COG1113	amino acid transport
H4J00_15240	COG2197	response regulator
H4J00_15245	COG0531	amino acid
H4J00_15305	COG0754	glutathionylspermidine amidase activity
H4J00_15330	COG1842	Phage shock protein A
H4J00_15345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H4J00_15440	COG3039	Transposase
H4J00_15770	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H4J00_15795	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H4J00_15810	COG2197	response regulator
H4J00_15815	COG4585	Histidine kinase
H4J00_15830	COG2894	cell division
H4J00_15835	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H4J00_15845	COG0642	Histidine kinase
H4J00_15850	COG0745	RESPONSE REGULATOR receiver
H4J00_15855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H4J00_15865	COG2194	sulfuric ester hydrolase activity
H4J00_15895	COG3551	Protein conserved in bacteria
H4J00_15930	COG0753	catalase activity
H4J00_15965	COG2207	Transcriptional regulator
H4J00_15965	COG1917	Cupin 2, conserved barrel domain protein
H4J00_15975	COG1506	peptidase
H4J00_15975	COG0823	Involved in the tonB-independent uptake of proteins
H4J00_15990	COG1297	OPT oligopeptide transporter protein
H4J00_16005	COG0587	DNA-directed DNA polymerase activity
H4J00_16085	COG3039	Transposase
H4J00_16090	COG0732	type I restriction modification DNA specificity domain
H4J00_16125	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
H4J00_16155	COG1309	transcriptional regulator
H4J00_16170	COG0308	aminopeptidase N
H4J00_16185	COG0330	HflC and HflK could
H4J00_16190	COG0330	HflC and HflK could
H4J00_16210	COG0678	peroxiredoxin activity
H4J00_16265	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4J00_16280	COG3829	transcription factor binding
H4J00_16290	COG3039	Transposase
H4J00_16315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4J00_16320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H4J00_16330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4J00_16335	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_16360	COG1399	metal-binding, possibly nucleic acid-binding protein
H4J00_16380	COG0714	Associated with various cellular activities
H4J00_16400	COG0537	adenosine 5'-monophosphoramidase activity
H4J00_16410	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H4J00_16430	COG0314	molybdopterin synthase activity
H4J00_16435	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H4J00_16440	COG0315	cyclic pyranopterin monophosphate synthase activity
H4J00_16450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H4J00_16455	COG1234	tRNA 3'-trailer cleavage
H4J00_16460	COG3642	lipopolysaccharide core region biosynthetic process
H4J00_16465	COG0859	PFAM glycosyl transferase family 9
H4J00_16480	COG0631	protein serine/threonine phosphatase activity
H4J00_16485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4J00_16510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4J00_16550	COG0544	peptidyl-prolyl cis-trans isomerase activity
H4J00_16595	COG0473	3-isopropylmalate dehydrogenase activity
H4J00_16610	COG4783	chaperone-mediated protein folding
H4J00_16625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H4J00_16635	COG0438	transferase activity, transferring glycosyl groups
H4J00_16640	COG0671	phosphoesterase, PA-phosphatase related
H4J00_16645	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4J00_16670	COG2833	Protein of unknown function (DUF455)
H4J00_16690	COG0285	dihydrofolate synthase activity
H4J00_16695	COG0406	alpha-ribazole phosphatase activity
H4J00_16730	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H4J00_16735	COG4208	sulfate ABC transporter
H4J00_16740	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H4J00_16745	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H4J00_16750	COG0156	8-amino-7-oxononanoate synthase activity
H4J00_16775	COG0604	alcohol dehydrogenase
H4J00_16780	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4J00_16780	COG1902	pentaerythritol trinitrate reductase activity
H4J00_16810	COG0584	glycerophosphoryl diester phosphodiesterase
H4J00_16835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H4J00_16840	COG1217	gtp-binding protein TYPA
H4J00_16860	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H4J00_16875	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H4J00_16880	COG0203	ribosomal protein L17
H4J00_16890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H4J00_16895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H4J00_16905	COG0201	protein transport
H4J00_16910	COG0200	Binds to the 23S rRNA
H4J00_16915	COG1841	ribosomal large subunit assembly
H4J00_16945	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H4J00_16950	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H4J00_16955	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H4J00_16960	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H4J00_16965	COG0255	Belongs to the universal ribosomal protein uL29 family
H4J00_16970	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H4J00_16980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H4J00_16990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H4J00_16995	COG0089	rRNA binding
H4J00_17000	COG0088	Forms part of the polypeptide exit tunnel
H4J00_17010	COG0051	transcription antitermination factor activity, RNA binding
H4J00_17030	COG0049	tRNA binding
H4J00_17035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H4J00_17040	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H4J00_17045	COG0085	RNA polymerase activity
H4J00_17055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H4J00_17060	COG0081	regulation of translation
H4J00_17065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H4J00_17070	COG0250	Participates in transcription elongation, termination and antitermination
H4J00_17075	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4J00_17105	COG0012	GTP binding
H4J00_17110	COG0193	aminoacyl-tRNA hydrolase activity
H4J00_17120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H4J00_17135	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H4J00_17145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H4J00_17150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H4J00_17160	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4J00_17180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4J00_17185	COG1295	ribonuclease BN
H4J00_17215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H4J00_17225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4J00_17280	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H4J00_17330	COG2890	protein-(glutamine-N5) methyltransferase activity
H4J00_17340	COG3634	alkyl hydroperoxide reductase activity
H4J00_17345	COG0583	DNA-binding transcription factor activity
H4J00_17355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H4J00_17360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4J00_17370	COG2197	response regulator
H4J00_17400	COG0697	spore germination
H4J00_17430	COG3386	PFAM SMP-30 Gluconolaconase
H4J00_17450	COG1024	Enoyl-CoA hydratase
H4J00_17460	COG0318	PFAM AMP-dependent synthetase and ligase
H4J00_17465	COG0583	DNA-binding transcription factor activity
H4J00_17470	COG3384	dioxygenase
H4J00_17500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4J00_17505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4J00_17515	COG2096	Adenosyltransferase
H4J00_17520	COG0123	including yeast histone deacetylase and acetoin utilization protein
H4J00_17535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H4J00_17545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H4J00_17550	COG2967	ApaG domain
H4J00_17555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4J00_17575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H4J00_17595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H4J00_17610	COG0642	Histidine kinase
H4J00_17625	COG4181	ATPase activity
H4J00_17635	COG2175	clavaminate synthase activity
H4J00_17650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4J00_17670	COG0667	Aldo Keto reductase
H4J00_17680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H4J00_17685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4J00_17695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4J00_17710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H4J00_17750	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H4J00_17755	COG2226	methyltransferase
H4J00_17800	COG0604	alcohol dehydrogenase
H4J00_17800	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_17800	COG3321	synthase
H4J00_17810	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H4J00_17825	COG0494	nUDIX hydrolase
H4J00_17840	COG1388	LysM domain
H4J00_17840	COG4942	peptidase
H4J00_17850	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H4J00_17870	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H4J00_17875	COG1181	Belongs to the D-alanine--D-alanine ligase family
H4J00_17880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4J00_17895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4J00_17900	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H4J00_17915	COG3116	cell division
H4J00_17920	COG0275	rRNA processing
H4J00_17960	COG0792	nuclease activity
H4J00_17965	COG1988	membrane-bound metal-dependent
H4J00_17970	COG0277	FAD linked oxidase domain protein
H4J00_17975	COG0745	RESPONSE REGULATOR receiver
H4J00_17980	COG2205	protein histidine kinase activity
H4J00_17990	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H4J00_17995	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H4J00_18015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H4J00_18020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4J00_18025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H4J00_18045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4J00_18045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4J00_18060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H4J00_18070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H4J00_18090	COG0488	(ABC) transporter
H4J00_18140	COG2205	protein histidine kinase activity
H4J00_18180	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H4J00_18240	COG0726	polysaccharide deacetylase
H4J00_18240	COG1649	PFAM Uncharacterised BCR, COG1649
H4J00_18245	COG1215	transferase activity, transferring glycosyl groups
H4J00_18255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H4J00_18260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4J00_18265	COG1609	Transcriptional regulator
H4J00_18275	COG2188	Transcriptional regulator
H4J00_18290	COG3250	beta-galactosidase activity
H4J00_18325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H4J00_18330	COG4191	Histidine kinase
H4J00_18335	COG0784	Response regulator, receiver
H4J00_18340	COG4251	negative regulation of phosphorylation
H4J00_18345	COG2823	Periplasmic or secreted lipoprotein
H4J00_18350	COG0673	inositol 2-dehydrogenase activity
H4J00_18355	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H4J00_18390	COG1056	cytidyltransferase-related domain
H4J00_18390	COG1051	belongs to the nudix hydrolase family
H4J00_18415	COG2921	Belongs to the UPF0250 family
H4J00_18430	COG1686	Belongs to the peptidase S11 family
H4J00_18435	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H4J00_18440	COG2951	lytic endotransglycosylase activity
H4J00_18480	COG3409	Peptidoglycan-binding domain 1 protein
H4J00_18480	COG5632	N-Acetylmuramoyl-L-alanine amidase
H4J00_18480	COG1388	LysM domain
H4J00_18495	COG0772	Belongs to the SEDS family
H4J00_18510	COG1792	Involved in formation and maintenance of cell shape
H4J00_18515	COG1077	Cell shape determining protein MreB Mrl
H4J00_18520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4J00_18540	COG3300	MHYT domain
H4J00_18540	COG5001	Diguanylate cyclase
H4J00_18585	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H4J00_18605	COG2832	Protein of unknown function (DUF454)
H4J00_18615	COG0436	Aminotransferase
H4J00_18625	COG1505	serine-type exopeptidase activity
H4J00_18650	COG0181	hydroxymethylbilane synthase activity
H4J00_18660	COG3275	phosphorelay sensor kinase activity
H4J00_18675	COG3039	Transposase
H4J00_18695	COG0659	secondary active sulfate transmembrane transporter activity
H4J00_18775	COG0598	Magnesium transport protein CorA
H4J00_18785	COG1113	amino acid transport
H4J00_18805	COG4305	rare lipoprotein A
H4J00_18810	COG0697	spore germination
H4J00_18865	COG4221	oxidoreductase activity
H4J00_18905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4J00_18930	COG0459	protein refolding
H4J00_18960	COG2860	membrane
H4J00_18965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4J00_18970	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H4J00_18975	COG2201	protein-glutamate methylesterase activity
H4J00_18980	COG2177	Part of the ABC transporter FtsEX involved in
H4J00_18985	COG2884	Cell division ATP-binding protein ftsE
H4J00_18995	COG3118	belongs to the thioredoxin family
H4J00_19000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H4J00_19035	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H4J00_19035	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H4J00_19045	COG1473	amidohydrolase
H4J00_19050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4J00_19055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4J00_19085	COG5383	Protein conserved in bacteria
H4J00_19125	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H4J00_19130	COG3023	N-Acetylmuramoyl-L-alanine amidase
H4J00_19140	COG4948	Mandelate Racemase Muconate Lactonizing
H4J00_19155	COG0531	amino acid
H4J00_19175	COG4682	membrane
H4J00_19185	COG2133	pyrroloquinoline quinone binding
H4J00_19205	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H4J00_19210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H4J00_19220	COG1610	YqeY-like protein
H4J00_19235	COG1295	ribonuclease BN
H4J00_19240	COG0358	DNA primase activity
H4J00_19295	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H4J00_19310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4J00_19365	COG0739	heme binding
H4J00_19380	COG2211	Major facilitator Superfamily
H4J00_19385	COG0708	Exodeoxyribonuclease III
H4J00_19425	COG2111	Na H antiporter
H4J00_19425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4J00_19430	COG1006	Multisubunit Na H antiporter MnhC subunit
H4J00_19435	COG0651	ATP synthesis coupled electron transport
H4J00_19445	COG2212	antiporter activity
H4J00_19450	COG1320	monovalent cation:proton antiporter activity
H4J00_19460	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H4J00_19485	COG3104	oligopeptide transport
H4J00_19490	COG3483	tryptophan 2,3-dioxygenase activity
H4J00_19500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H4J00_19515	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4J00_19530	COG3039	Transposase
H4J00_19535	COG0513	Belongs to the DEAD box helicase family
H4J00_19585	COG2801	Transposase and inactivated derivatives
H4J00_19605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4J00_19610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4J00_19620	COG0045	succinate-CoA ligase (ADP-forming) activity
H4J00_19620	COG1042	CoA-binding domain protein
H4J00_19620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4J00_19630	COG2239	Acts as a magnesium transporter
H4J00_19650	COG3039	Transposase
H4J00_19665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H4J00_19670	COG3387	PFAM Glycoside hydrolase 15-related
H4J00_19685	COG3100	YcgL domain-containing protein
H4J00_19690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4J00_19700	COG0463	Glycosyl transferase, family 2
H4J00_19720	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_19760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H4J00_19775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4J00_19820	COG0408	coproporphyrinogen oxidase activity
H4J00_19890	COG0210	DNA helicase
H4J00_19905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4J00_19910	COG0583	DNA-binding transcription factor activity
H4J00_19915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4J00_19925	COG2159	amidohydrolase
H4J00_19950	COG0357	Ribosomal RNA small subunit methyltransferase G
H4J00_19955	COG3540	Alkaline phosphatase
H4J00_19965	COG2091	lysine biosynthetic process via aminoadipic acid
H4J00_19980	COG0708	Exodeoxyribonuclease III
H4J00_19995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4J00_20000	COG3162	membrane
H4J00_20040	COG1414	Transcriptional regulator
H4J00_20050	COG2205	protein histidine kinase activity
H4J00_20060	COG3459	Glycosyltransferase 36 associated
H4J00_20070	COG3265	gluconokinase activity
H4J00_20075	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4J00_20080	COG3039	Transposase
H4J00_20095	COG0339	signal peptide processing
H4J00_20125	COG0564	pseudouridine synthase activity
H4J00_20140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H4J00_20150	COG1181	Belongs to the D-alanine--D-alanine ligase family
H4J00_20155	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_20165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4J00_20170	COG0318	PFAM AMP-dependent synthetase and ligase
H4J00_20175	COG0727	PFAM Uncharacterised protein family (UPF0153)
H4J00_20180	COG0596	Alpha beta hydrolase
H4J00_20185	COG3177	Filamentation induced by cAMP protein fic
H4J00_20190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4J00_20205	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4J00_20230	COG4191	Histidine kinase
H4J00_20235	COG0028	Belongs to the TPP enzyme family
H4J00_20250	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H4J00_20255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4J00_20300	COG3039	Transposase
H4J00_20310	COG0183	Belongs to the thiolase family
H4J00_20335	COG3039	Transposase
H4J00_20340	COG3039	Transposase
H4J00_20370	COG2032	superoxide dismutase activity
H4J00_20375	COG2032	superoxide dismutase activity
H4J00_20380	COG2204	response regulator
H4J00_20385	COG3852	Histidine kinase
H4J00_20390	COG0004	ammonium transporteR
H4J00_20395	COG0347	Belongs to the P(II) protein family
H4J00_20400	COG0174	glutamine synthetase
H4J00_20405	COG1968	undecaprenyl-diphosphatase activity
H4J00_20450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4J00_20460	COG2062	phosphohistidine phosphatase, SixA
H4J00_20465	COG0489	protein tyrosine kinase activity
H4J00_20485	COG1396	sequence-specific DNA binding
H4J00_20490	COG3550	peptidyl-serine autophosphorylation
H4J00_20495	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H4J00_20500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4J00_20515	COG0517	IMP dehydrogenase activity
H4J00_20515	COG1125	glycine betaine transport
H4J00_20530	COG1119	ATPase activity
H4J00_20540	COG1473	amidohydrolase
H4J00_20545	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4J00_20555	COG1522	sequence-specific DNA binding
H4J00_20560	COG3186	Phenylalanine-4-hydroxylase
H4J00_20580	COG1609	Transcriptional regulator
H4J00_20605	COG0366	Alpha amylase catalytic
H4J00_20610	COG0366	Alpha amylase catalytic
H4J00_20620	COG2831	hemolysin activation secretion protein
H4J00_20625	COG3210	domain, Protein
H4J00_20680	COG3135	benzoate transporter
H4J00_20700	COG0676	glucose-6-phosphate 1-epimerase activity
H4J00_20755	COG0302	gtp cyclohydrolase
H4J00_20785	COG0477	Major facilitator Superfamily
H4J00_20795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4J00_20845	COG3237	CsbD-like
H4J00_20935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4J00_20955	COG1755	Isoprenylcysteine carboxyl methyltransferase
H4J00_20960	COG1304	FMN binding
H4J00_20965	COG3039	Transposase
H4J00_20975	COG4772	TonB-dependent receptor
H4J00_20985	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H4J00_21010	COG1272	protein, Hemolysin III
H4J00_21015	COG1205	dead DEAH box helicase
H4J00_21015	COG1111	helicase
H4J00_21075	COG0069	glutamate synthase activity
H4J00_21075	COG0070	glutamate synthase
H4J00_21075	COG0067	glutamate synthase
H4J00_21080	COG0493	'glutamate synthase
H4J00_21090	COG0531	amino acid
H4J00_21100	COG1322	Protein conserved in bacteria
H4J00_21110	COG0386	Belongs to the glutathione peroxidase family
H4J00_21115	COG2853	Lipoprotein
H4J00_21130	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4J00_21135	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4J00_21140	COG1127	ABC transporter
H4J00_21175	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H4J00_21180	COG1074	ATP-dependent DNA helicase activity
H4J00_21185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4J00_21240	COG2826	transposase and inactivated derivatives, IS30 family
H4J00_21260	COG3039	Transposase
H4J00_21270	COG2124	cytochrome p450
H4J00_21275	COG2124	cytochrome p450
H4J00_21280	COG1141	Ferredoxin
H4J00_21285	COG1028	Short-chain dehydrogenase reductase Sdr
H4J00_21290	COG2124	cytochrome p450
H4J00_21295	COG0142	geranyltranstransferase activity
H4J00_21300	COG1657	PFAM Prenyltransferase squalene oxidase
H4J00_21310	COG1304	FMN binding
H4J00_21325	COG0564	pseudouridine synthase activity
H4J00_21350	COG3706	GGDEF domain
H4J00_21360	COG1929	Belongs to the glycerate kinase type-1 family
H4J00_21365	COG2271	Major facilitator Superfamily
H4J00_21385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H4J00_21390	COG0861	Integral membrane protein TerC family
H4J00_21400	COG0584	glycerophosphoryl diester phosphodiesterase
H4J00_21410	COG0671	phosphoesterase, PA-phosphatase related
H4J00_21415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H4J00_21420	COG0726	polysaccharide deacetylase