locus-tag	class	description
XPE_00030	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XPE_00035	COG0343	queuine tRNA-ribosyltransferase activity
XPE_00040	COG1862	Preprotein translocase
XPE_00050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XPE_00100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XPE_00100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XPE_00105	COG1105	Belongs to the carbohydrate kinase PfkB family
XPE_00110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XPE_00110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPE_00115	COG1609	Transcriptional regulator
XPE_00120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPE_00125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPE_00135	COG2902	Dehydrogenase
XPE_00140	COG0477	Major facilitator Superfamily
XPE_00150	COG2205	protein histidine kinase activity
XPE_00150	COG0784	Response regulator, receiver
XPE_00150	COG5002	protein histidine kinase activity
XPE_00155	COG2733	membrane
XPE_00180	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XPE_00185	COG0243	molybdopterin cofactor binding
XPE_00195	COG0477	Major facilitator Superfamily
XPE_00200	COG2703	oxygen carrier activity
XPE_00205	COG0745	RESPONSE REGULATOR receiver
XPE_00205	COG3706	GGDEF domain
XPE_00210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XPE_00215	COG0174	glutamine synthetase
XPE_00220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XPE_00235	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XPE_00255	COG3842	ATPase activity
XPE_00265	COG1176	ABC-type spermidine putrescine transport system, permease component I
XPE_00270	COG1177	transmembrane transport
XPE_00275	COG1012	belongs to the aldehyde dehydrogenase family
XPE_00290	COG4535	Mg2 and Co2 transporter CorC
XPE_00300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XPE_00310	COG1702	phosphate starvation-inducible protein PhoH
XPE_00315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XPE_00330	COG0741	lytic transglycosylase activity
XPE_00340	COG0723	plastoquinol--plastocyanin reductase activity
XPE_00345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XPE_00350	COG2857	Cytochrome c1
XPE_00355	COG0625	glutathione transferase activity
XPE_00360	COG2969	positive regulation of protein catabolic process
XPE_00380	COG1201	RNA secondary structure unwinding
XPE_00385	COG2094	Belongs to the DNA glycosylase MPG family
XPE_00390	COG0840	transmembrane signaling receptor activity
XPE_00395	COG0835	chemotaxis
XPE_00445	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XPE_00460	COG1570	exodeoxyribonuclease VII activity
XPE_00465	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XPE_00470	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XPE_00470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XPE_00475	COG0802	atpase or kinase
XPE_00480	COG0860	N-Acetylmuramoyl-L-alanine amidase
XPE_00485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XPE_00510	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_00515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XPE_00520	COG0501	Belongs to the peptidase M48B family
XPE_00530	COG2081	HI0933 family
XPE_00535	COG4681	YaeQ
XPE_00545	COG0625	glutathione transferase activity
XPE_00555	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XPE_00560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XPE_00565	COG0513	Belongs to the DEAD box helicase family
XPE_00590	COG0483	inositol monophosphate 1-phosphatase activity
XPE_00605	COG5001	Diguanylate cyclase
XPE_00605	COG3300	MHYT domain
XPE_00610	COG1509	lysine 2,3-aminomutase activity
XPE_00615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XPE_00625	COG0402	S-adenosylhomocysteine deaminase activity
XPE_00630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XPE_00645	COG4677	pectinesterase activity
XPE_00670	COG4302	ethanolamine ammonia-lyase activity
XPE_00700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XPE_00705	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XPE_00710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XPE_00720	COG2166	iron-sulfur cluster assembly
XPE_00725	COG0215	cysteine-tRNA ligase activity
XPE_00735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XPE_00740	COG0137	argininosuccinate synthase activity
XPE_00755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XPE_00765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XPE_00770	COG0165	Argininosuccinate lyase
XPE_00780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XPE_00785	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XPE_00815	COG1294	oxidase, subunit
XPE_00825	COG4988	ABC transporter
XPE_00830	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XPE_00835	COG1278	Cold shock
XPE_00840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XPE_00860	COG1138	Cytochrome C-type biogenesis protein
XPE_00865	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XPE_00885	COG4133	protoheme IX ABC transporter activity
XPE_00890	COG0436	Aminotransferase
XPE_00910	COG1187	pseudouridine synthase activity
XPE_00915	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XPE_00920	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XPE_00925	COG2350	Protein conserved in bacteria
XPE_00960	COG0395	ABC-type sugar transport system, permease component
XPE_00985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XPE_00990	COG2957	Belongs to the agmatine deiminase family
XPE_01000	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XPE_01005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XPE_01010	COG0539	negative regulation of cytoplasmic translation
XPE_01015	COG0776	regulation of translation
XPE_01025	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XPE_01030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XPE_01040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XPE_01045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XPE_01045	COG0475	glutathione-regulated potassium exporter activity
XPE_01055	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XPE_01065	COG0519	Catalyzes the synthesis of GMP from XMP
XPE_01065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XPE_01075	COG2818	Glycosylase
XPE_01080	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_01090	COG0583	DNA-binding transcription factor activity
XPE_01100	COG3002	Belongs to the UPF0753 family
XPE_01105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XPE_01110	COG0583	DNA-binding transcription factor activity
XPE_01120	COG0633	Ferredoxin
XPE_01140	COG0583	DNA-binding transcription factor activity
XPE_01155	COG2197	response regulator
XPE_01160	COG4585	Histidine kinase
XPE_01170	COG1335	isochorismatase
XPE_01185	COG2814	Major facilitator Superfamily
XPE_01205	COG1914	H( )-stimulated, divalent metal cation uptake system
XPE_01210	COG1321	iron dependent repressor
XPE_01215	COG0590	tRNA wobble adenosine to inosine editing
XPE_01220	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XPE_01225	COG0668	transmembrane transport
XPE_01235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XPE_01250	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_01255	COG1183	phosphatidylcholine synthase activity
XPE_01265	COG3243	poly(R)-hydroxyalkanoic acid synthase
XPE_01280	COG0723	plastoquinol--plastocyanin reductase activity
XPE_01280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XPE_01290	COG2183	response to ionizing radiation
XPE_01295	COG0784	Response regulator, receiver
XPE_01295	COG2205	protein histidine kinase activity
XPE_01365	COG0800	Aldolase
XPE_01370	COG0129	dihydroxy-acid dehydratase activity
XPE_01375	COG0363	glucosamine-6-phosphate deaminase activity
XPE_01380	COG0837	glucose binding
XPE_01385	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XPE_01395	COG0354	folic acid binding
XPE_01410	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XPE_01425	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XPE_01430	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XPE_01440	COG4591	ABC-type transport system involved in lipoprotein release permease component
XPE_01445	COG1136	(ABC) transporter
XPE_01460	COG0811	peptide transport
XPE_01470	COG1132	(ABC) transporter
XPE_01475	COG1663	tetraacyldisaccharide 4'-kinase activity
XPE_01480	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XPE_01485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XPE_01495	COG0322	excinuclease ABC activity
XPE_01500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XPE_01525	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XPE_01555	COG1530	ribonuclease E activity
XPE_01565	COG3064	Membrane
XPE_01570	COG0428	transporter
XPE_01580	COG2154	pterin-4-alpha-carbinolamine dehydratase
XPE_01585	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XPE_01585	COG0316	Belongs to the HesB IscA family
XPE_01600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPE_01605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPE_01610	COG1309	transcriptional regulator
XPE_01620	COG0596	Alpha beta hydrolase
XPE_01645	COG0363	glucosamine-6-phosphate deaminase activity
XPE_01660	COG2226	methyltransferase
XPE_01660	COG1073	alpha beta
XPE_01670	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_01700	COG0640	Transcriptional regulator
XPE_01735	COG2197	response regulator
XPE_01740	COG4585	Histidine kinase
XPE_01770	COG1858	cytochrome C peroxidase
XPE_01800	COG0515	serine threonine protein kinase
XPE_01805	COG0631	protein serine/threonine phosphatase activity
XPE_01840	COG3501	Rhs element vgr protein
XPE_01990	COG4566	intracellular signal transduction
XPE_02000	COG5001	Diguanylate cyclase
XPE_02015	COG3685	Protein conserved in bacteria
XPE_02035	COG0243	molybdopterin cofactor binding
XPE_02045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XPE_02050	COG2223	nitrite transmembrane transporter activity
XPE_02055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XPE_02065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XPE_02065	COG1648	precorrin-2 dehydrogenase activity
XPE_02090	COG0746	molybdenum cofactor guanylyltransferase activity
XPE_02095	COG0303	'Molybdopterin
XPE_02105	COG0708	Exodeoxyribonuclease III
XPE_02150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XPE_02155	COG0303	'Molybdopterin
XPE_02160	COG1160	GTP binding
XPE_02165	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XPE_02175	COG1426	Protein conserved in bacteria
XPE_02185	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XPE_02190	COG0105	UTP biosynthetic process
XPE_02200	COG1024	Enoyl-CoA hydratase
XPE_02200	COG1250	3-hydroxyacyl-CoA dehydrogenase
XPE_02205	COG0183	Belongs to the thiolase family
XPE_02210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XPE_02215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XPE_02230	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XPE_02240	COG1674	ftsk spoiiie
XPE_02245	COG0492	ferredoxin-NADP+ reductase activity
XPE_02260	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XPE_02265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XPE_02270	COG0542	response to heat
XPE_02275	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XPE_02285	COG0482	sulfurtransferase activity
XPE_02290	COG2915	High frequency lysogenization protein hflD homolog
XPE_02325	COG5002	protein histidine kinase activity
XPE_02345	COG0835	chemotaxis
XPE_02345	COG0784	Response regulator, receiver
XPE_02355	COG1558	bacterial-type flagellum-dependent cell motility
XPE_02360	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XPE_02365	COG1749	Flagellar hook protein flgE
XPE_02370	COG4787	bacterial-type flagellum-dependent cell motility
XPE_02380	COG4786	Flagellar basal body rod
XPE_02385	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XPE_02390	COG1706	bacterial-type flagellum-dependent cell motility
XPE_02395	COG1705	Flagellar rod assembly protein muramidase FlgJ
XPE_02395	COG3951	Flagellar rod assembly protein muramidase FlgJ
XPE_02405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XPE_02410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XPE_02415	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XPE_02445	COG2201	protein-glutamate methylesterase activity
XPE_02450	COG2204	response regulator
XPE_02465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XPE_02470	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_02475	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_02510	COG1677	Flagellar hook-basal body complex protein FliE
XPE_02560	COG3190	flagellar
XPE_02575	COG1987	bacterial-type flagellum assembly
XPE_02580	COG1684	flagellar biosynthetic protein fliR
XPE_02585	COG5001	Diguanylate cyclase
XPE_02585	COG3300	MHYT domain
XPE_02595	COG5001	Diguanylate cyclase
XPE_02595	COG3300	MHYT domain
XPE_02620	COG0455	bacterial-type flagellum organization
XPE_02640	COG0643	Histidine kinase
XPE_02640	COG2198	Histidine kinase
XPE_02660	COG2963	transposase activity
XPE_02695	COG2963	transposase activity
XPE_02700	COG2801	Transposase and inactivated derivatives
XPE_02725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XPE_02730	COG1360	Flagellar Motor Protein
XPE_02735	COG1192	Involved in chromosome partitioning
XPE_02750	COG0745	RESPONSE REGULATOR receiver
XPE_02765	COG0840	transmembrane signaling receptor activity
XPE_02775	COG0840	transmembrane signaling receptor activity
XPE_02780	COG0840	transmembrane signaling receptor activity
XPE_02790	COG0840	transmembrane signaling receptor activity
XPE_02795	COG0840	transmembrane signaling receptor activity
XPE_02800	COG0840	transmembrane signaling receptor activity
XPE_02805	COG0840	transmembrane signaling receptor activity
XPE_02815	COG0840	transmembrane signaling receptor activity
XPE_02830	COG0840	transmembrane signaling receptor activity
XPE_02835	COG0840	transmembrane signaling receptor activity
XPE_02855	COG0835	chemotaxis
XPE_02865	COG0840	transmembrane signaling receptor activity
XPE_02875	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XPE_02880	COG2201	protein-glutamate methylesterase activity
XPE_02890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XPE_02920	COG0318	PFAM AMP-dependent synthetase and ligase
XPE_02925	COG1024	Enoyl-CoA hydratase
XPE_02930	COG0784	Response regulator, receiver
XPE_02930	COG2198	Histidine kinase
XPE_02930	COG2205	protein histidine kinase activity
XPE_02945	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XPE_02950	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XPE_02955	COG3279	Response regulator of the LytR AlgR family
XPE_02965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XPE_02975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XPE_02980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XPE_02990	COG0505	Belongs to the CarA family
XPE_02995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XPE_03005	COG2258	MOSC domain
XPE_03010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XPE_03055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XPE_03075	COG0277	FAD linked oxidase domain protein
XPE_03080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XPE_03090	COG0531	amino acid
XPE_03095	COG0531	amino acid
XPE_03100	COG0235	Class ii aldolase
XPE_03105	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XPE_03110	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XPE_03125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XPE_03125	COG0140	phosphoribosyl-ATP diphosphatase activity
XPE_03130	COG0107	imidazoleglycerol-phosphate synthase activity
XPE_03135	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XPE_03140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XPE_03145	COG0131	Imidazoleglycerol-phosphate dehydratase
XPE_03145	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XPE_03150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XPE_03155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XPE_03160	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XPE_03170	COG0124	histidyl-tRNA synthetase
XPE_03175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XPE_03185	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
XPE_03200	COG0527	aspartate kinase activity
XPE_03200	COG0460	homoserine dehydrogenase
XPE_03205	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
XPE_03220	COG2963	transposase activity
XPE_03225	COG2801	Transposase and inactivated derivatives
XPE_03265	COG1012	belongs to the aldehyde dehydrogenase family
XPE_03285	COG0167	dihydroorotate dehydrogenase activity
XPE_03290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XPE_03300	COG1794	racemase activity, acting on amino acids and derivatives
XPE_03310	COG0671	phosphoesterase, PA-phosphatase related
XPE_03315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XPE_03330	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XPE_03335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XPE_03340	COG3706	GGDEF domain
XPE_03340	COG5001	Diguanylate cyclase
XPE_03340	COG4251	negative regulation of phosphorylation
XPE_03340	COG2203	Gaf domain
XPE_03355	COG1472	Belongs to the glycosyl hydrolase 3 family
XPE_03380	COG0166	Belongs to the GPI family
XPE_03385	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XPE_03390	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XPE_03395	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XPE_03415	COG1469	GTP cyclohydrolase I activity
XPE_03420	COG0860	N-Acetylmuramoyl-L-alanine amidase
XPE_03435	COG0477	Major facilitator Superfamily
XPE_03440	COG2115	Belongs to the xylose isomerase family
XPE_03445	COG1070	Carbohydrate kinase
XPE_03455	COG1501	Belongs to the glycosyl hydrolase 31 family
XPE_03495	COG0800	Aldolase
XPE_03500	COG4948	Mandelate Racemase Muconate Lactonizing
XPE_03510	COG3734	2-keto-3-deoxy-galactonokinase
XPE_03515	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XPE_03525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XPE_03540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XPE_03545	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XPE_03560	COG0351	phosphomethylpyrimidine kinase
XPE_03585	COG0583	DNA-binding transcription factor activity
XPE_03590	COG1741	Belongs to the pirin family
XPE_03610	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XPE_03615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XPE_03620	COG2137	regulation of response to DNA damage stimulus
XPE_03630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XPE_03635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XPE_03645	COG1546	Belongs to the CinA family
XPE_03650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XPE_03655	COG1923	regulation of RNA biosynthetic process
XPE_03660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XPE_03665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XPE_03670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XPE_03675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XPE_03680	COG1534	Rna-binding protein
XPE_03695	COG1238	metal cluster binding
XPE_03700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XPE_03705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XPE_03710	COG2840	Smr protein MutS2
XPE_03715	COG0585	pseudouridine synthase activity
XPE_03720	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XPE_03725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XPE_03730	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XPE_03735	COG0148	phosphopyruvate hydratase activity
XPE_03750	COG0504	CTP synthase activity
XPE_03775	COG0306	phosphate transporter
XPE_03790	COG1253	flavin adenine dinucleotide binding
XPE_03805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XPE_03810	COG2271	Major facilitator Superfamily
XPE_03815	COG1132	(ABC) transporter
XPE_03820	COG1136	(ABC) transporter
XPE_03840	COG0438	transferase activity, transferring glycosyl groups
XPE_03850	COG2264	protein methyltransferase activity
XPE_03880	COG2244	polysaccharide biosynthetic process
XPE_03935	COG1595	DNA-templated transcription, initiation
XPE_03950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XPE_03960	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XPE_03970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XPE_03985	COG0784	Response regulator, receiver
XPE_03985	COG4191	Histidine kinase
XPE_03990	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XPE_04000	COG5002	protein histidine kinase activity
XPE_04000	COG2205	protein histidine kinase activity
XPE_04000	COG0784	Response regulator, receiver
XPE_04020	COG0840	transmembrane signaling receptor activity
XPE_04035	COG0583	DNA-binding transcription factor activity
XPE_04040	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XPE_04045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XPE_04060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XPE_04065	COG1605	Chorismate mutase
XPE_04065	COG0077	Prephenate dehydratase
XPE_04070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XPE_04075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XPE_04080	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XPE_04120	COG1228	amidohydrolase
XPE_04125	COG2986	histidine ammonia-lyase
XPE_04135	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XPE_04145	COG4993	Dehydrogenase
XPE_04155	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XPE_04170	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XPE_04175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XPE_04180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XPE_04190	COG3115	cell septum assembly
XPE_04200	COG0359	binds to the 23S rRNA
XPE_04205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XPE_04210	COG0360	Binds together with S18 to 16S ribosomal RNA
XPE_04215	COG0316	Belongs to the HesB IscA family
XPE_04225	COG0017	Asparaginyl-tRNA synthetase
XPE_04295	COG0288	reversible hydration of carbon dioxide
XPE_04300	COG0662	Cupin 2, conserved barrel domain protein
XPE_04310	COG3844	kynureninase activity
XPE_04315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XPE_04325	COG2925	Exonuclease
XPE_04335	COG0667	Aldo Keto reductase
XPE_04350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XPE_04355	COG0116	Belongs to the methyltransferase superfamily
XPE_04355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XPE_04400	COG0494	nUDIX hydrolase
XPE_04410	COG1024	Enoyl-CoA hydratase
XPE_04420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XPE_04425	COG0659	secondary active sulfate transmembrane transporter activity
XPE_04450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XPE_04455	COG0573	inorganic phosphate transmembrane transporter activity
XPE_04460	COG0581	inorganic phosphate transmembrane transporter activity
XPE_04465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XPE_04470	COG0704	Plays a role in the regulation of phosphate uptake
XPE_04480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPE_04485	COG3706	GGDEF domain
XPE_04495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XPE_04505	COG0557	exoribonuclease II activity
XPE_04535	COG1960	acyl-CoA dehydrogenase activity
XPE_04545	COG0646	methionine synthase
XPE_04545	COG1410	methionine synthase
XPE_04550	COG1410	methionine synthase
XPE_04550	COG0646	methionine synthase
XPE_04560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XPE_04585	COG2900	Belongs to the SlyX family
XPE_04600	COG0386	Belongs to the glutathione peroxidase family
XPE_04610	COG1725	Transcriptional regulator
XPE_04615	COG1131	(ABC) transporter
XPE_04645	COG1253	flavin adenine dinucleotide binding
XPE_04665	COG2850	peptidyl-arginine hydroxylation
XPE_04700	COG1132	(ABC) transporter
XPE_04705	COG0583	DNA-binding transcription factor activity
XPE_04735	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XPE_04740	COG0484	heat shock protein binding
XPE_04745	COG0443	Heat shock 70 kDa protein
XPE_04750	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XPE_04755	COG1420	regulation of RNA biosynthetic process
XPE_04760	COG0497	DNA recombination
XPE_04770	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XPE_04785	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XPE_04820	COG3706	GGDEF domain
XPE_04830	COG3706	GGDEF domain
XPE_04865	COG0583	DNA-binding transcription factor activity
XPE_04880	COG0415	Belongs to the DNA photolyase family
XPE_04885	COG0305	Participates in initiation and elongation during chromosome replication
XPE_04895	COG0367	asparagine synthase
XPE_04915	COG1960	acyl-CoA dehydrogenase activity
XPE_04930	COG0084	hydrolase, TatD family'
XPE_04935	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XPE_04995	COG0386	Belongs to the glutathione peroxidase family
XPE_05000	COG0339	signal peptide processing
XPE_05060	COG2814	Major facilitator Superfamily
XPE_05065	COG1566	PFAM secretion protein HlyD family protein
XPE_05090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XPE_05105	COG4774	siderophore transport
XPE_05115	COG0367	asparagine synthase
XPE_05120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XPE_05125	COG1393	Belongs to the ArsC family
XPE_05135	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XPE_05140	COG0024	Methionine aminopeptidase
XPE_05175	COG0052	Belongs to the universal ribosomal protein uS2 family
XPE_05180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XPE_05185	COG3706	GGDEF domain
XPE_05185	COG0745	RESPONSE REGULATOR receiver
XPE_05190	COG0528	UMP kinase activity
XPE_05195	COG0233	cytoplasmic translational termination
XPE_05200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XPE_05205	COG0575	Belongs to the CDS family
XPE_05210	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XPE_05215	COG0750	zinc metalloprotease
XPE_05230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPE_05235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XPE_05240	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPE_05245	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPE_05260	COG0825	malonyl-CoA metabolic process
XPE_05295	COG1695	Transcriptional regulator
XPE_05315	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XPE_05325	COG2040	homocysteine
XPE_05330	COG0833	amino acid
XPE_05345	COG0346	lactoylglutathione lyase activity
XPE_05365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XPE_05365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XPE_05375	COG2878	Part of a membrane complex involved in electron transport
XPE_05395	COG1595	DNA-templated transcription, initiation
XPE_05420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XPE_05435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XPE_05440	COG0251	oxidation-reduction process
XPE_05450	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XPE_05450	COG0392	lysyltransferase activity
XPE_05485	COG2814	Major facilitator Superfamily
XPE_05490	COG1902	pentaerythritol trinitrate reductase activity
XPE_05495	COG2824	Alkylphosphonate utilization operon protein PhnA
XPE_05505	COG1047	Peptidyl-prolyl cis-trans
XPE_05510	COG1077	Cell shape determining protein MreB Mrl
XPE_05525	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XPE_05535	COG5487	UPF0391 membrane protein
XPE_05540	COG1451	nucleotide metabolic process
XPE_05565	COG0183	Belongs to the thiolase family
XPE_05580	COG3706	GGDEF domain
XPE_05580	COG0745	RESPONSE REGULATOR receiver
XPE_05600	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XPE_05600	COG1793	dna ligase
XPE_05610	COG1793	dna ligase
XPE_05615	COG1201	RNA secondary structure unwinding
XPE_05625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XPE_05630	COG1278	Cold shock
XPE_05635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XPE_05645	COG1472	Belongs to the glycosyl hydrolase 3 family
XPE_05650	COG3046	protein related to deoxyribodipyrimidine photolyase
XPE_05655	COG1233	COG1233 Phytoene dehydrogenase and related
XPE_05660	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XPE_05670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XPE_05685	COG1381	Involved in DNA repair and RecF pathway recombination
XPE_05690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XPE_05695	COG0571	ribonuclease III activity
XPE_05710	COG0481	GTPase activity
XPE_05715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XPE_05730	COG1250	3-hydroxyacyl-CoA dehydrogenase
XPE_05730	COG1024	Enoyl-CoA hydratase
XPE_05750	COG1024	Enoyl-CoA hydratase
XPE_05755	COG1960	acyl-CoA dehydrogenase activity
XPE_05775	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XPE_05780	COG3250	beta-galactosidase activity
XPE_05795	COG0840	transmembrane signaling receptor activity
XPE_05820	COG3483	tryptophan 2,3-dioxygenase activity
XPE_05830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XPE_05840	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XPE_05860	COG0534	Mate efflux family protein
XPE_05865	COG0335	large ribosomal subunit rRNA binding
XPE_05870	COG0336	Belongs to the RNA methyltransferase TrmD family
XPE_05875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XPE_05880	COG0228	four-way junction DNA binding
XPE_05885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XPE_05895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XPE_05900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XPE_05920	COG4191	Histidine kinase
XPE_05920	COG0784	Response regulator, receiver
XPE_05925	COG3850	Histidine kinase
XPE_05925	COG3437	response regulator, receiver
XPE_05925	COG4999	Histidine kinase
XPE_05925	COG2205	protein histidine kinase activity
XPE_05930	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XPE_05940	COG2205	protein histidine kinase activity
XPE_05945	COG5507	3-demethylubiquinone-9 3-methyltransferase
XPE_05955	COG4771	TonB-dependent receptor
XPE_05980	COG2172	sigma factor antagonist activity
XPE_05985	COG1366	Belongs to the anti-sigma-factor antagonist family
XPE_05990	COG1366	Belongs to the anti-sigma-factor antagonist family
XPE_06000	COG0326	Molecular chaperone. Has ATPase activity
XPE_06005	COG2207	Transcriptional regulator
XPE_06015	COG3152	Membrane
XPE_06030	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XPE_06035	COG1845	cytochrome c oxidase, subunit III
XPE_06040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XPE_06055	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XPE_06060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XPE_06065	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XPE_06070	COG0196	riboflavin kinase activity
XPE_06080	COG0268	Binds directly to 16S ribosomal RNA
XPE_06085	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XPE_06090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XPE_06095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XPE_06100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XPE_06105	COG0824	Thioesterase
XPE_06115	COG1024	Enoyl-CoA hydratase
XPE_06120	COG1946	Acyl-CoA thioesterase
XPE_06130	COG1595	DNA-templated transcription, initiation
XPE_06145	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XPE_06165	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XPE_06190	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XPE_06205	COG2197	response regulator
XPE_06210	COG4585	Histidine kinase
XPE_06225	COG0850	regulation of cytokinetic process
XPE_06230	COG2894	cell division
XPE_06235	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XPE_06245	COG0642	Histidine kinase
XPE_06250	COG0745	RESPONSE REGULATOR receiver
XPE_06265	COG2194	sulfuric ester hydrolase activity
XPE_06285	COG2814	Major facilitator Superfamily
XPE_06310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XPE_06310	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XPE_06315	COG2272	Belongs to the type-B carboxylesterase lipase family
XPE_06320	COG0656	L-ascorbic acid biosynthetic process
XPE_06325	COG0753	catalase activity
XPE_06350	COG1917	Cupin 2, conserved barrel domain protein
XPE_06350	COG2207	Transcriptional regulator
XPE_06365	COG0823	Involved in the tonB-independent uptake of proteins
XPE_06365	COG1506	peptidase
XPE_06380	COG1297	OPT oligopeptide transporter protein
XPE_06400	COG0587	DNA-directed DNA polymerase activity
XPE_06415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XPE_06450	COG2080	2 iron, 2 sulfur cluster binding
XPE_06455	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XPE_06460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XPE_06485	COG0492	ferredoxin-NADP+ reductase activity
XPE_06495	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_06505	COG3537	Alpha-1,2-mannosidase
XPE_06510	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_06515	COG3387	PFAM Glycoside hydrolase 15-related
XPE_06525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XPE_06530	COG0328	RNA-DNA hybrid ribonuclease activity
XPE_06530	COG0406	alpha-ribazole phosphatase activity
XPE_06570	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
XPE_06600	COG1309	transcriptional regulator
XPE_06605	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_06615	COG0308	aminopeptidase N
XPE_06620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XPE_06630	COG0330	HflC and HflK could
XPE_06635	COG0330	HflC and HflK could
XPE_06655	COG0678	peroxiredoxin activity
XPE_06665	COG4953	penicillin-binding protein 1C
XPE_06685	COG2373	Large extracellular alpha-helical protein
XPE_06730	COG3829	transcription factor binding
XPE_06760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XPE_06765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XPE_06775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XPE_06795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XPE_06800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XPE_06805	COG1399	metal-binding, possibly nucleic acid-binding protein
XPE_06810	COG0424	maF-like protein
XPE_06825	COG0714	Associated with various cellular activities
XPE_06845	COG0537	adenosine 5'-monophosphoramidase activity
XPE_06850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XPE_06855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XPE_06880	COG4680	protein conserved in bacteria
XPE_06925	COG2003	Belongs to the UPF0758 family
XPE_07010	COG0314	molybdopterin synthase activity
XPE_07015	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XPE_07020	COG0315	cyclic pyranopterin monophosphate synthase activity
XPE_07030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XPE_07035	COG1234	tRNA 3'-trailer cleavage
XPE_07040	COG3642	lipopolysaccharide core region biosynthetic process
XPE_07045	COG0859	PFAM glycosyl transferase family 9
XPE_07105	COG0631	protein serine/threonine phosphatase activity
XPE_07110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPE_07115	COG0328	RNA-DNA hybrid ribonuclease activity
XPE_07125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XPE_07135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XPE_07165	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XPE_07170	COG0740	serine-type endopeptidase activity
XPE_07175	COG0544	peptidyl-prolyl cis-trans isomerase activity
XPE_07185	COG3852	Histidine kinase
XPE_07215	COG0473	3-isopropylmalate dehydrogenase activity
XPE_07230	COG4783	chaperone-mediated protein folding
XPE_07245	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XPE_07255	COG0438	transferase activity, transferring glycosyl groups
XPE_07260	COG0671	phosphoesterase, PA-phosphatase related
XPE_07265	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPE_07275	COG3291	Pkd domain containing protein
XPE_07280	COG2833	Protein of unknown function (DUF455)
XPE_07305	COG0285	dihydrofolate synthase activity
XPE_07310	COG0406	alpha-ribazole phosphatase activity
XPE_07330	COG1063	alcohol dehydrogenase
XPE_07345	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XPE_07350	COG4208	sulfate ABC transporter
XPE_07355	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XPE_07360	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XPE_07365	COG0156	8-amino-7-oxononanoate synthase activity
XPE_07385	COG2885	chlorophyll binding
XPE_07390	COG0604	alcohol dehydrogenase
XPE_07395	COG0446	pyridine nucleotide-disulphide oxidoreductase
XPE_07395	COG1902	pentaerythritol trinitrate reductase activity
XPE_07415	COG0625	glutathione transferase activity
XPE_07420	COG0039	L-malate dehydrogenase activity
XPE_07425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XPE_07440	COG0154	amidase activity
XPE_07450	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XPE_07470	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XPE_07475	COG0203	ribosomal protein L17
XPE_07480	COG0202	RNA polymerase activity
XPE_07485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XPE_07490	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XPE_07495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XPE_07500	COG0201	protein transport
XPE_07505	COG0200	Binds to the 23S rRNA
XPE_07510	COG1841	ribosomal large subunit assembly
XPE_07515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XPE_07520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XPE_07525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XPE_07530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XPE_07535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XPE_07540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XPE_07545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XPE_07550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XPE_07555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XPE_07560	COG0255	Belongs to the universal ribosomal protein uL29 family
XPE_07565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XPE_07570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XPE_07575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XPE_07580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XPE_07585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XPE_07595	COG0088	Forms part of the polypeptide exit tunnel
XPE_07600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XPE_07605	COG0051	transcription antitermination factor activity, RNA binding
XPE_07620	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XPE_07625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XPE_07630	COG0049	tRNA binding
XPE_07635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XPE_07640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XPE_07645	COG0085	RNA polymerase activity
XPE_07650	COG0222	ribosome binding
XPE_07655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XPE_07660	COG0081	regulation of translation
XPE_07665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XPE_07670	COG0250	Participates in transcription elongation, termination and antitermination
XPE_07675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XPE_07685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XPE_07705	COG0012	GTP binding
XPE_07710	COG0193	aminoacyl-tRNA hydrolase activity
XPE_07715	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XPE_07720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XPE_07730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XPE_07735	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XPE_07745	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XPE_07750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XPE_07765	COG0521	Mo-molybdopterin cofactor biosynthetic process
XPE_07780	COG1254	Belongs to the acylphosphatase family
XPE_07785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XPE_07790	COG1295	ribonuclease BN
XPE_07815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XPE_07820	COG1404	Belongs to the peptidase S8 family
XPE_07830	COG1404	Belongs to the peptidase S8 family
XPE_07835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XPE_07850	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XPE_07855	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XPE_07875	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XPE_07890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XPE_07890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XPE_07910	COG2890	protein-(glutamine-N5) methyltransferase activity
XPE_07920	COG3634	alkyl hydroperoxide reductase activity
XPE_07925	COG0583	DNA-binding transcription factor activity
XPE_07935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XPE_07940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XPE_07950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XPE_07960	COG2197	response regulator
XPE_07985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XPE_07995	COG0697	spore germination
XPE_08020	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XPE_08030	COG3386	PFAM SMP-30 Gluconolaconase
XPE_08050	COG1024	Enoyl-CoA hydratase
XPE_08060	COG0318	PFAM AMP-dependent synthetase and ligase
XPE_08065	COG0583	DNA-binding transcription factor activity
XPE_08070	COG3384	dioxygenase
XPE_08100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XPE_08105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XPE_08120	COG2096	Adenosyltransferase
XPE_08125	COG0123	including yeast histone deacetylase and acetoin utilization protein
XPE_08130	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XPE_08135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XPE_08140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XPE_08145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XPE_08150	COG2967	ApaG domain
XPE_08155	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XPE_08170	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XPE_08175	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XPE_08195	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XPE_08205	COG0642	Histidine kinase
XPE_08220	COG4181	ATPase activity
XPE_08230	COG2175	clavaminate synthase activity
XPE_08240	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XPE_08245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XPE_08265	COG4771	TonB-dependent receptor
XPE_08275	COG0667	Aldo Keto reductase
XPE_08285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XPE_08290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XPE_08300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XPE_08305	COG4106	trans-aconitate 2-methyltransferase activity
XPE_08315	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XPE_08355	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XPE_08365	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XPE_08370	COG2226	methyltransferase
XPE_08400	COG0366	Alpha amylase catalytic
XPE_08420	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_08420	COG0604	alcohol dehydrogenase
XPE_08420	COG3321	synthase
XPE_08435	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XPE_08445	COG0494	nUDIX hydrolase
XPE_08450	COG0653	protein targeting
XPE_08455	COG0739	heme binding
XPE_08465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XPE_08480	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XPE_08485	COG1181	Belongs to the D-alanine--D-alanine ligase family
XPE_08490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XPE_08495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XPE_08505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XPE_08510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XPE_08515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XPE_08525	COG3116	cell division
XPE_08530	COG0275	rRNA processing
XPE_08535	COG2001	Belongs to the MraZ family
XPE_08570	COG0792	nuclease activity
XPE_08575	COG1988	membrane-bound metal-dependent
XPE_08580	COG0277	FAD linked oxidase domain protein
XPE_08590	COG0745	RESPONSE REGULATOR receiver
XPE_08595	COG2205	protein histidine kinase activity
XPE_08605	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XPE_08610	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XPE_08640	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XPE_08645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XPE_08650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XPE_08670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XPE_08670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XPE_08680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XPE_08685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XPE_08695	COG0488	(ABC) transporter
XPE_08705	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
XPE_08710	COG3791	Glutathione-dependent formaldehyde-activating
XPE_08735	COG0745	RESPONSE REGULATOR receiver
XPE_08740	COG2205	protein histidine kinase activity
XPE_08750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XPE_08780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XPE_08785	COG1012	belongs to the aldehyde dehydrogenase family
XPE_08790	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XPE_08795	COG0617	tRNA 3'-terminal CCA addition
XPE_08810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XPE_08815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XPE_08820	COG1609	Transcriptional regulator
XPE_08855	COG4795	General secretion pathway protein
XPE_08875	COG1459	type II secretion system
XPE_08925	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_08930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XPE_08935	COG4191	Histidine kinase
XPE_08940	COG0784	Response regulator, receiver
XPE_08945	COG4251	negative regulation of phosphorylation
XPE_08950	COG2823	Periplasmic or secreted lipoprotein
XPE_08955	COG0673	inositol 2-dehydrogenase activity
XPE_08960	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XPE_08995	COG1056	cytidyltransferase-related domain
XPE_08995	COG1051	belongs to the nudix hydrolase family
XPE_09005	COG0583	DNA-binding transcription factor activity
XPE_09020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XPE_09025	COG0321	lipoyl(octanoyl) transferase activity
XPE_09030	COG2921	Belongs to the UPF0250 family
XPE_09040	COG1686	Belongs to the peptidase S11 family
XPE_09050	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XPE_09055	COG2951	lytic endotransglycosylase activity
XPE_09070	COG0772	Belongs to the SEDS family
XPE_09085	COG1792	Involved in formation and maintenance of cell shape
XPE_09090	COG1077	Cell shape determining protein MreB Mrl
XPE_09100	COG3284	Transcriptional regulator
XPE_09110	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
XPE_09150	COG0308	aminopeptidase N
XPE_09155	COG5001	Diguanylate cyclase
XPE_09155	COG3300	MHYT domain
XPE_09185	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XPE_09190	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XPE_09195	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XPE_09205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XPE_09215	COG2832	Protein of unknown function (DUF454)
XPE_09230	COG1505	serine-type exopeptidase activity
XPE_09270	COG0181	hydroxymethylbilane synthase activity
XPE_09280	COG3275	phosphorelay sensor kinase activity
XPE_09290	COG2943	transferase activity, transferring hexosyl groups
XPE_09305	COG3706	GGDEF domain
XPE_09310	COG0659	secondary active sulfate transmembrane transporter activity
XPE_09315	COG5297	Belongs to the glycosyl hydrolase family 6
XPE_09315	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XPE_09320	COG0840	transmembrane signaling receptor activity
XPE_09355	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XPE_09370	COG0598	Magnesium transport protein CorA
XPE_09380	COG1113	amino acid transport
XPE_09400	COG0697	spore germination
XPE_09425	COG1959	2 iron, 2 sulfur cluster binding
XPE_09430	COG3706	GGDEF domain
XPE_09480	COG0435	Glutathione S-transferase
XPE_09490	COG4221	oxidoreductase activity
XPE_09545	COG2963	transposase activity
XPE_09550	COG2801	Transposase and inactivated derivatives
XPE_09685	COG0546	phosphoglycolate phosphatase activity
XPE_09690	COG1802	Transcriptional regulator
XPE_09700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XPE_09705	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
XPE_09725	COG3052	prosthetic group binding
XPE_09750	COG2353	YceI-like domain
XPE_09755	COG0778	Nitroreductase
XPE_09785	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XPE_09790	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XPE_09815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XPE_09830	COG0459	protein refolding
XPE_09835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
XPE_09845	COG2356	endonuclease I
XPE_09855	COG1324	tolerance protein
XPE_09865	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XPE_09870	COG0511	ligase activity, forming carbon-carbon bonds
XPE_09880	COG0439	Biotin carboxylase
XPE_09900	COG2264	protein methyltransferase activity
XPE_09925	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XPE_09930	COG4589	Belongs to the CDS family
XPE_09955	COG0671	phosphoesterase, PA-phosphatase related
XPE_09955	COG2453	phosphatase
XPE_09960	COG2267	carboxylic ester hydrolase activity
XPE_09965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XPE_09970	COG0138	bifunctional purine biosynthesis protein purh
XPE_09980	COG0151	Belongs to the GarS family
XPE_09985	COG1289	transmembrane transporter activity
XPE_09990	COG2814	Major facilitator Superfamily
XPE_10015	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XPE_10035	COG0316	Belongs to the HesB IscA family
XPE_10075	COG1051	belongs to the nudix hydrolase family
XPE_10090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XPE_10095	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XPE_10100	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XPE_10110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XPE_10115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XPE_10125	COG0134	indole-3-glycerol-phosphate synthase activity
XPE_10130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XPE_10160	COG1597	lipid kinase activity
XPE_10165	COG0456	acetyltransferase
XPE_10175	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XPE_10180	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XPE_10200	COG3179	chitinase
XPE_10220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XPE_10220	COG2111	Na H antiporter
XPE_10225	COG1006	Multisubunit Na H antiporter MnhC subunit
XPE_10230	COG0651	ATP synthesis coupled electron transport
XPE_10240	COG2212	antiporter activity
XPE_10245	COG1320	monovalent cation:proton antiporter activity
XPE_10260	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XPE_10265	COG2852	Protein conserved in bacteria
XPE_10285	COG3104	oligopeptide transport
XPE_10290	COG3483	tryptophan 2,3-dioxygenase activity
XPE_10300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XPE_10315	COG0508	dehydrogenase complex catalyzes the overall conversion of
XPE_10330	COG0513	Belongs to the DEAD box helicase family
XPE_10345	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_10350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPE_10385	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_10390	COG0702	epimerase
XPE_10415	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XPE_10420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XPE_10425	COG0297	glycogen (starch) synthase activity
XPE_10430	COG3706	GGDEF domain
XPE_10430	COG0745	RESPONSE REGULATOR receiver
XPE_10435	COG2354	Protein conserved in bacteria
XPE_10445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XPE_10455	COG1368	sulfuric ester hydrolase activity
XPE_10460	COG1511	domain protein
XPE_10460	COG3264	Mechanosensitive ion channel
XPE_10495	COG2963	transposase activity
XPE_10560	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XPE_10640	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XPE_10645	COG1040	competence protein
XPE_10650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XPE_10655	COG0156	8-amino-7-oxononanoate synthase activity
XPE_10665	COG2267	carboxylic ester hydrolase activity
XPE_10670	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_10710	COG0445	tRNA wobble uridine modification
XPE_10730	COG1414	Transcriptional regulator
XPE_10745	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XPE_10750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XPE_10760	COG3485	protocatechuate 3,4-dioxygenase
XPE_10765	COG3485	protocatechuate 3,4-dioxygenase
XPE_10775	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XPE_10780	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XPE_10805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XPE_10810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XPE_10865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XPE_10880	COG0129	dihydroxy-acid dehydratase activity
XPE_10900	COG2801	Transposase and inactivated derivatives
XPE_10905	COG2963	transposase activity
XPE_10910	COG2801	Transposase and inactivated derivatives
XPE_10920	COG2963	transposase activity
XPE_10985	COG1733	regulation of RNA biosynthetic process
XPE_10990	COG0702	epimerase
XPE_11025	COG0583	DNA-binding transcription factor activity
XPE_11030	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XPE_11045	COG1538	Outer membrane efflux protein
XPE_11055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPE_11060	COG2205	protein histidine kinase activity
XPE_11065	COG0745	RESPONSE REGULATOR receiver
XPE_11085	COG1902	pentaerythritol trinitrate reductase activity
XPE_11090	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XPE_11095	COG2267	carboxylic ester hydrolase activity
XPE_11105	COG2814	Major facilitator Superfamily
XPE_11110	COG0583	DNA-binding transcription factor activity
XPE_11125	COG0084	hydrolase, TatD family'
XPE_11150	COG2252	PERMEase
XPE_11190	COG0583	DNA-binding transcription factor activity
XPE_11200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XPE_11220	COG2072	flavoprotein involved in K transport
XPE_11225	COG2351	hydroxyisourate hydrolase activity
XPE_11230	COG4807	Protein conserved in bacteria
XPE_11240	COG1643	Atp-dependent helicase
XPE_11250	COG1187	pseudouridine synthase activity
XPE_11265	COG2130	NADP-dependent
XPE_11285	COG1764	response to oxidative stress
XPE_11290	COG1846	Transcriptional regulator
XPE_11295	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XPE_11305	COG0697	spore germination
XPE_11315	COG0523	cobalamin synthesis protein
XPE_11375	COG1960	acyl-CoA dehydrogenase activity
XPE_11380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XPE_11410	COG3706	GGDEF domain
XPE_11415	COG2224	Isocitrate lyase
XPE_11420	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XPE_11425	COG0583	DNA-binding transcription factor activity
XPE_11430	COG0475	glutathione-regulated potassium exporter activity
XPE_11460	COG0339	signal peptide processing
XPE_11465	COG1446	asparaginase
XPE_11485	COG0564	pseudouridine synthase activity
XPE_11495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XPE_11515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XPE_11520	COG0318	PFAM AMP-dependent synthetase and ligase
XPE_11530	COG0596	Alpha beta hydrolase
XPE_11535	COG3177	Filamentation induced by cAMP protein fic
XPE_11540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XPE_11555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XPE_11580	COG4191	Histidine kinase
XPE_11585	COG0028	Belongs to the TPP enzyme family
XPE_11600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XPE_11605	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XPE_11610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XPE_11645	COG0183	Belongs to the thiolase family
XPE_11660	COG2032	superoxide dismutase activity
XPE_11665	COG2032	superoxide dismutase activity
XPE_11670	COG2204	response regulator
XPE_11675	COG3852	Histidine kinase
XPE_11680	COG0004	ammonium transporteR
XPE_11685	COG0347	Belongs to the P(II) protein family
XPE_11690	COG0174	glutamine synthetase
XPE_11700	COG1968	undecaprenyl-diphosphatase activity
XPE_11745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XPE_11755	COG2062	phosphohistidine phosphatase, SixA
XPE_11760	COG0489	protein tyrosine kinase activity
XPE_11800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XPE_11815	COG1125	glycine betaine transport
XPE_11830	COG1119	ATPase activity
XPE_11840	COG1473	amidohydrolase
XPE_11845	COG1752	Esterase of the alpha-beta hydrolase superfamily
XPE_11855	COG1522	sequence-specific DNA binding
XPE_11860	COG3186	Phenylalanine-4-hydroxylase
XPE_11870	COG2755	lipolytic protein G-D-S-L family
XPE_11880	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_11885	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XPE_11890	COG1609	Transcriptional regulator
XPE_11895	COG3507	Belongs to the glycosyl hydrolase 43 family
XPE_11910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XPE_11920	COG2755	lipolytic protein G-D-S-L family
XPE_11920	COG0657	acetylesterase activity
XPE_11925	COG2272	Belongs to the type-B carboxylesterase lipase family
XPE_11945	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XPE_11950	COG0366	Alpha amylase catalytic
XPE_11955	COG0366	Alpha amylase catalytic
XPE_12030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XPE_12040	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XPE_12045	COG3710	Transcriptional regulator
XPE_12065	COG2197	response regulator
XPE_12070	COG4585	Histidine kinase
XPE_12075	COG1755	Isoprenylcysteine carboxyl methyltransferase
XPE_12090	COG1304	FMN binding
XPE_12115	COG1012	belongs to the aldehyde dehydrogenase family
XPE_12130	COG4772	TonB-dependent receptor
XPE_12140	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XPE_12190	COG0714	Associated with various cellular activities
XPE_12230	COG0477	Major facilitator Superfamily
XPE_12240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XPE_12285	COG3237	CsbD-like
XPE_12325	COG2249	NAD(P)H dehydrogenase (quinone) activity
XPE_12340	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_12345	COG0300	oxidoreductase activity
XPE_12365	COG1272	protein, Hemolysin III
XPE_12370	COG1205	dead DEAH box helicase
XPE_12370	COG1111	helicase
XPE_12465	COG0070	glutamate synthase
XPE_12465	COG0067	glutamate synthase
XPE_12465	COG0069	glutamate synthase activity
XPE_12470	COG0493	'glutamate synthase
XPE_12480	COG1064	alcohol dehydrogenase
XPE_12490	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XPE_12495	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XPE_12500	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XPE_12510	COG2234	aminopeptidase activity
XPE_12520	COG4942	peptidase
XPE_12525	COG0793	Belongs to the peptidase S41A family
XPE_12570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XPE_12580	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XPE_12615	COG0501	Belongs to the peptidase M48B family
XPE_12625	COG0187	DNA topoisomerase II activity
XPE_12630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XPE_12640	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XPE_12650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
XPE_12655	COG0594	ribonuclease P activity
XPE_12660	COG0706	membrane insertase activity
XPE_12665	COG0726	polysaccharide deacetylase
XPE_12670	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XPE_12685	COG0584	glycerophosphoryl diester phosphodiesterase
XPE_12700	COG0861	Integral membrane protein TerC family
XPE_12705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XPE_12720	COG2271	Major facilitator Superfamily
XPE_12725	COG1929	Belongs to the glycerate kinase type-1 family
XPE_12730	COG3835	regulator
XPE_12735	COG2203	Gaf domain
XPE_12735	COG2199	diguanylate cyclase activity
XPE_12750	COG3537	Alpha-1,2-mannosidase
XPE_12755	COG0531	amino acid
XPE_12775	COG0583	DNA-binding transcription factor activity
XPE_12780	COG0604	alcohol dehydrogenase
XPE_12785	COG1322	Protein conserved in bacteria
XPE_12795	COG0386	Belongs to the glutathione peroxidase family
XPE_12805	COG2853	Lipoprotein
XPE_12820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XPE_12825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XPE_12830	COG1127	ABC transporter
XPE_12865	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XPE_12870	COG1074	ATP-dependent DNA helicase activity
XPE_12880	COG3549	Plasmid maintenance system killer
XPE_12930	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_12940	COG1309	transcriptional regulator
XPE_12985	COG0564	pseudouridine synthase activity
XPE_13045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XPE_13055	COG4221	oxidoreductase activity
XPE_13060	COG0583	DNA-binding transcription factor activity
XPE_13070	COG0477	Major facilitator Superfamily
XPE_13075	COG1289	transmembrane transporter activity
XPE_13085	COG1566	PFAM secretion protein HlyD family protein
XPE_13100	COG0302	gtp cyclohydrolase
XPE_13120	COG0730	response to heat
XPE_13125	COG3012	SEC-C Motif Domain Protein
XPE_13135	COG0676	glucose-6-phosphate 1-epimerase activity
XPE_13155	COG3135	benzoate transporter
XPE_13185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XPE_13195	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XPE_13205	COG1435	thymidine kinase activity
XPE_13210	COG0210	DNA helicase
XPE_13225	COG3132	Protein of unknown function, DUF480
XPE_13235	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XPE_13240	COG0284	orotidine-5'-phosphate decarboxylase activity
XPE_13270	COG2937	Belongs to the GPAT DAPAT family
XPE_13315	COG2211	Major facilitator Superfamily
XPE_13330	COG3693	PFAM glycoside hydrolase, family 10
XPE_13340	COG3693	PFAM glycoside hydrolase, family 10
XPE_13345	COG1904	glucuronate isomerase
XPE_13350	COG3250	beta-galactosidase activity
XPE_13360	COG3386	PFAM SMP-30 Gluconolaconase
XPE_13385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XPE_13435	COG0246	Mannitol dehydrogenase
XPE_13440	COG1472	Belongs to the glycosyl hydrolase 3 family
XPE_13450	COG4948	Mandelate Racemase Muconate Lactonizing
XPE_13460	COG3661	Belongs to the glycosyl hydrolase 67 family
XPE_13470	COG2115	Belongs to the xylose isomerase family
XPE_13475	COG0037	tRNA processing
XPE_13480	COG2974	May be involved in recombination
XPE_13500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XPE_13510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XPE_13515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XPE_13520	COG0805	protein transport
XPE_13530	COG0519	Catalyzes the synthesis of GMP from XMP
XPE_13530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XPE_13545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XPE_13550	COG0752	glycyl-tRNA synthetase alpha subunit
XPE_13560	COG0457	Tetratricopeptide repeat
XPE_13570	COG4771	TonB-dependent receptor
XPE_13575	COG0729	surface antigen
XPE_13580	COG2911	Protein conserved in bacteria
XPE_13605	COG3209	COG3209 Rhs family protein
XPE_13610	COG2963	transposase activity
XPE_13640	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XPE_13650	COG3265	gluconokinase activity
XPE_13655	COG2211	Major facilitator Superfamily
XPE_13660	COG3459	Glycosyltransferase 36 associated
XPE_13675	COG2205	protein histidine kinase activity
XPE_13680	COG1971	Probably functions as a manganese efflux pump
XPE_13690	COG1414	Transcriptional regulator
XPE_13695	COG0738	Major facilitator superfamily
XPE_13700	COG3254	rhamnose metabolic process
XPE_13705	COG4948	Mandelate Racemase Muconate Lactonizing
XPE_13715	COG0179	Fumarylacetoacetate (FAA) hydrolase
XPE_13720	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_13740	COG3507	Belongs to the glycosyl hydrolase 43 family
XPE_13775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XPE_13785	COG3162	membrane
XPE_13790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XPE_13800	COG0708	Exodeoxyribonuclease III
XPE_13815	COG2091	lysine biosynthetic process via aminoadipic acid
XPE_13825	COG3540	Alkaline phosphatase
XPE_13830	COG0357	Ribosomal RNA small subunit methyltransferase G
XPE_13855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPE_13870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
XPE_13875	COG0267	Belongs to the bacterial ribosomal protein bL33 family
XPE_13880	COG2159	amidohydrolase
XPE_13895	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XPE_13900	COG0583	DNA-binding transcription factor activity
XPE_13905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XPE_13920	COG0210	DNA helicase
XPE_14070	COG3501	Rhs element vgr protein
XPE_14085	COG0583	DNA-binding transcription factor activity
XPE_14090	COG0667	Aldo Keto reductase
XPE_14115	COG0631	protein serine/threonine phosphatase activity
XPE_14120	COG0515	serine threonine protein kinase
XPE_14155	COG0408	coproporphyrinogen oxidase activity
XPE_14200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XPE_14215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XPE_14255	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_14275	COG0463	Glycosyl transferase, family 2
XPE_14285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XPE_14290	COG3100	YcgL domain-containing protein
XPE_14300	COG3387	PFAM Glycoside hydrolase 15-related
XPE_14305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XPE_14330	COG2239	Acts as a magnesium transporter
XPE_14335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XPE_14335	COG0045	succinate-CoA ligase (ADP-forming) activity
XPE_14335	COG1042	CoA-binding domain protein
XPE_14350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XPE_14360	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XPE_14365	COG0716	FMN binding
XPE_14390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XPE_14395	COG0842	Transport permease protein
XPE_14400	COG1131	(ABC) transporter
XPE_14405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XPE_14430	COG1476	TRANSCRIPTIONal
XPE_14440	COG4555	ABC transporter
XPE_14475	COG0625	glutathione transferase activity
XPE_14525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XPE_14540	COG1199	ATP-dependent helicase activity
XPE_14575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XPE_14585	COG0745	RESPONSE REGULATOR receiver
XPE_14590	COG2205	protein histidine kinase activity
XPE_14620	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XPE_14620	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XPE_14625	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XPE_14640	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XPE_14680	COG3237	CsbD-like
XPE_14685	COG0180	Tryptophanyl-tRNA synthetase
XPE_14690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XPE_14710	COG0697	spore germination
XPE_14735	COG1136	(ABC) transporter
XPE_14740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPE_14745	COG4585	Histidine kinase
XPE_14750	COG2197	response regulator
XPE_14765	COG0753	catalase activity
XPE_14780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XPE_14785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XPE_14810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XPE_14830	COG0642	Histidine kinase
XPE_14835	COG0745	RESPONSE REGULATOR receiver
XPE_14840	COG1090	epimerase
XPE_14875	COG1690	Belongs to the RtcB family
XPE_14910	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XPE_14925	COG0606	chelatase, subunit chli
XPE_14945	COG3291	Pkd domain containing protein
XPE_14945	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XPE_14965	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XPE_14970	COG1166	arginine decarboxylase activity
XPE_14975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XPE_14985	COG2755	lipolytic protein G-D-S-L family
XPE_14985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XPE_14990	COG4221	oxidoreductase activity
XPE_15005	COG0018	arginyl-trna synthetase
XPE_15010	COG2003	Belongs to the UPF0758 family
XPE_15015	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XPE_15020	COG0756	dUTP diphosphatase activity
XPE_15040	COG0463	Glycosyl transferase, family 2
XPE_15055	COG1475	DNA binding
XPE_15060	COG1192	Involved in chromosome partitioning
XPE_15070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XPE_15075	COG0708	Exodeoxyribonuclease III
XPE_15080	COG2211	Major facilitator Superfamily
XPE_15090	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XPE_15095	COG0739	heme binding
XPE_15100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XPE_15140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XPE_15155	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XPE_15185	COG0109	protoheme IX farnesyltransferase activity
XPE_15200	COG0358	DNA primase activity
XPE_15205	COG1295	ribonuclease BN
XPE_15215	COG1610	YqeY-like protein
XPE_15220	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XPE_15225	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XPE_15230	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XPE_15240	COG2133	pyrroloquinoline quinone binding
XPE_15260	COG0531	amino acid
XPE_15270	COG4948	Mandelate Racemase Muconate Lactonizing
XPE_15280	COG3023	N-Acetylmuramoyl-L-alanine amidase
XPE_15285	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XPE_15330	COG5383	Protein conserved in bacteria
XPE_15340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPE_15345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPE_15350	COG1473	amidohydrolase
XPE_15355	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XPE_15355	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XPE_15360	COG1652	LysM domain
XPE_15380	COG0583	DNA-binding transcription factor activity
XPE_15385	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XPE_15400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XPE_15405	COG3118	belongs to the thioredoxin family
XPE_15415	COG2884	Cell division ATP-binding protein ftsE
XPE_15420	COG2177	Part of the ABC transporter FtsEX involved in
XPE_15425	COG3437	response regulator, receiver
XPE_15430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XPE_15435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XPE_15440	COG2860	membrane
XPE_15445	COG1252	NADH dehydrogenase
XPE_15460	COG0625	glutathione transferase activity
XPE_15465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XPE_15485	COG0534	Mate efflux family protein
XPE_15490	COG0616	signal peptide processing
XPE_15505	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_15520	COG0009	L-threonylcarbamoyladenylate synthase
XPE_15525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XPE_15525	COG1754	DNA topoisomerase type I activity
XPE_15545	COG0758	DNA mediated transformation
XPE_15550	COG1652	LysM domain
XPE_15555	COG0242	peptide deformylase activity
XPE_15560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XPE_15565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XPE_15565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XPE_15615	COG1560	Kdo2-lipid A biosynthetic process
XPE_15620	COG1490	D-aminoacyl-tRNA deacylase activity
XPE_15625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XPE_15865	COG4695	Portal protein
XPE_15895	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_15910	COG0024	Methionine aminopeptidase
XPE_15920	COG0038	chloride channel
XPE_15925	COG0659	secondary active sulfate transmembrane transporter activity
XPE_15955	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XPE_15960	COG0583	DNA-binding transcription factor activity
XPE_15980	COG0251	oxidation-reduction process
XPE_16055	COG1063	alcohol dehydrogenase
XPE_16070	COG1132	(ABC) transporter
XPE_16090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XPE_16095	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_16110	COG1294	oxidase, subunit
XPE_16115	COG1271	oxidase subunit
XPE_16130	COG2204	response regulator
XPE_16165	COG3546	catalase activity
XPE_16170	COG3685	Protein conserved in bacteria
XPE_16190	COG2972	Histidine kinase
XPE_16205	COG0531	amino acid
XPE_16220	COG3590	peptidase
XPE_16235	COG0667	Aldo Keto reductase
XPE_16245	COG0583	DNA-binding transcription factor activity
XPE_16250	COG3384	dioxygenase
XPE_16260	COG1573	uracil-dna glycosylase
XPE_16265	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XPE_16275	COG0025	NhaP-type Na H and K H
XPE_16280	COG1131	(ABC) transporter
XPE_16285	COG0842	Transport permease protein
XPE_16335	COG1522	sequence-specific DNA binding
XPE_16340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XPE_16345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XPE_16365	COG2205	protein histidine kinase activity
XPE_16365	COG2202	Pas domain
XPE_16385	COG2813	Specifically methylates the guanine in position
XPE_16390	COG1187	pseudouridine synthase activity
XPE_16395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XPE_16420	COG0784	Response regulator, receiver
XPE_16420	COG5002	protein histidine kinase activity
XPE_16420	COG2198	Histidine kinase
XPE_16430	COG1666	GTP binding
XPE_16435	COG0697	spore germination
XPE_16440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XPE_16445	COG2011	ABC-type metal ion transport system permease component
XPE_16485	COG0508	dehydrogenase complex catalyzes the overall conversion of
XPE_16495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XPE_16515	COG0356	it plays a direct role in the translocation of protons across the membrane
XPE_16525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XPE_16530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XPE_16535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XPE_16540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XPE_16545	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XPE_16550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XPE_16565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XPE_16570	COG4191	Histidine kinase
XPE_16575	COG2204	response regulator
XPE_16585	COG0577	efflux transmembrane transporter activity
XPE_16590	COG0577	efflux transmembrane transporter activity
XPE_16595	COG1136	(ABC) transporter
XPE_16600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPE_16605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XPE_16655	COG0339	signal peptide processing
XPE_16670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XPE_16680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XPE_16695	COG1956	GAF domain-containing protein
XPE_16700	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XPE_16710	COG0720	synthase
XPE_16715	COG0513	Belongs to the DEAD box helicase family
XPE_16730	COG0625	glutathione transferase activity
XPE_16760	COG0626	cystathionine gamma-synthase activity
XPE_16790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XPE_16800	COG0277	FAD linked oxidase domain protein
XPE_16805	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XPE_16805	COG0546	phosphoglycolate phosphatase activity
XPE_16820	COG2086	electron transfer activity
XPE_16850	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XPE_16850	COG0662	Cupin 2, conserved barrel domain protein
XPE_16855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XPE_16860	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XPE_16900	COG3218	ABC-type transport auxiliary lipoprotein component
XPE_16900	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XPE_16905	COG1127	ABC transporter
XPE_16910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XPE_16925	COG0442	prolyl-tRNA aminoacylation
XPE_16935	COG1183	phosphatidylcholine synthase activity
XPE_16965	COG0525	valine-tRNA ligase activity
XPE_16980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XPE_16990	COG0795	lipopolysaccharide-transporting ATPase activity
XPE_17005	COG4974	Belongs to the 'phage' integrase family
XPE_17015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XPE_17025	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XPE_17025	COG0047	phosphoribosylformylglycinamidine synthase activity
XPE_17030	COG5295	Hep Hag repeat protein
XPE_17035	COG1404	Belongs to the peptidase S8 family
XPE_17040	COG5295	Hep Hag repeat protein
XPE_17045	COG1404	Belongs to the peptidase S8 family
XPE_17050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XPE_17060	COG1459	type II secretion system
XPE_17065	COG2165	general secretion pathway protein
XPE_17070	COG4970	Tfp pilus assembly protein FimT
XPE_17075	COG2165	general secretion pathway protein
XPE_17080	COG4795	General secretion pathway protein
XPE_17085	COG3156	type II secretion system protein K
XPE_17090	COG3166	PFAM Fimbrial assembly family protein
XPE_17105	COG1450	Type ii and iii secretion system protein
XPE_17115	COG2188	Transcriptional regulator
XPE_17160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XPE_17175	COG1215	transferase activity, transferring glycosyl groups
XPE_17180	COG1215	transferase activity, transferring glycosyl groups
XPE_17185	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XPE_17190	COG0457	Tetratricopeptide repeat
XPE_17220	COG0242	peptide deformylase activity
XPE_17225	COG1307	EDD domain protein, DegV family
XPE_17250	COG0402	S-adenosylhomocysteine deaminase activity
XPE_17255	COG3964	amidohydrolase
XPE_17270	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XPE_17275	COG0726	polysaccharide deacetylase
XPE_17290	COG0436	Aminotransferase
XPE_17295	COG1162	GTPase activity
XPE_17320	COG2211	Major facilitator Superfamily
XPE_17325	COG1609	Transcriptional regulator
XPE_17330	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_17335	COG2851	Citrate transporter
XPE_17355	COG0642	Histidine kinase
XPE_17360	COG1840	ABC-type Fe3 transport system, periplasmic component
XPE_17365	COG2197	response regulator
XPE_17380	COG0667	Aldo Keto reductase
XPE_17385	COG0583	DNA-binding transcription factor activity
XPE_17410	COG1301	dicarboxylic acid transport
XPE_17415	COG0280	phosphate acetyltransferase
XPE_17415	COG0281	malic enzyme
XPE_17440	COG1560	Kdo2-lipid A biosynthetic process
XPE_17450	COG1519	Transferase
XPE_17455	COG1538	Outer membrane efflux protein
XPE_17460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XPE_17470	COG3706	GGDEF domain
XPE_17480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XPE_17485	COG0066	3-isopropylmalate dehydratase activity
XPE_17490	COG0473	3-isopropylmalate dehydrogenase activity
XPE_17495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XPE_17515	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XPE_17520	COG0405	Gamma-glutamyltransferase
XPE_17540	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XPE_17545	COG3710	Transcriptional regulator
XPE_17565	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XPE_17575	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XPE_17590	COG0563	adenylate kinase activity
XPE_17595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XPE_17605	COG3781	membrane
XPE_17610	COG0671	phosphoesterase, PA-phosphatase related
XPE_17620	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_17625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XPE_17630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XPE_17660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XPE_17665	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XPE_17680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XPE_17700	COG0352	thiamine-phosphate diphosphorylase activity
XPE_17705	COG1773	rubredoxin
XPE_17710	COG2912	Transglutaminase-like superfamily
XPE_17720	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XPE_17730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XPE_17750	COG3079	Belongs to the UPF0149 family
XPE_17755	COG0006	proline dipeptidase activity
XPE_17765	COG0006	proline dipeptidase activity
XPE_17780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XPE_17785	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XPE_17795	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XPE_17800	COG1561	YicC-like family, N-terminal region
XPE_17805	COG0194	GDP metabolic process
XPE_17810	COG1758	RNA polymerase activity
XPE_17815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XPE_17825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XPE_17830	COG1957	nucleoside hydrolase
XPE_17835	COG0254	rRNA binding
XPE_17850	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XPE_17880	COG0714	Associated with various cellular activities
XPE_17900	COG2304	oxidoreductase activity
XPE_17915	COG1301	dicarboxylic acid transport
XPE_17920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XPE_17925	COG4773	Receptor
XPE_17930	COG0739	heme binding
XPE_17935	COG1376	ErfK ybiS ycfS ynhG family protein
XPE_17970	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XPE_17975	COG4149	molybdate abc transporter
XPE_17980	COG0725	ABC transporter, periplasmic molybdate-binding protein
XPE_17995	COG3047	cAMP biosynthetic process
XPE_18010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XPE_18030	COG0126	phosphoglycerate kinase activity
XPE_18040	COG0469	pyruvate kinase activity
XPE_18045	COG3588	fructose-bisphosphate aldolase
XPE_18050	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XPE_18065	COG1648	precorrin-2 dehydrogenase activity
XPE_18065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XPE_18110	COG0175	sulfate reduction
XPE_18115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XPE_18120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XPE_18125	COG0175	sulfate reduction
XPE_18130	COG2895	sulfate adenylyltransferase (ATP) activity
XPE_18130	COG0529	Catalyzes the synthesis of activated sulfate
XPE_18145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPE_18150	COG0308	aminopeptidase N
XPE_18165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XPE_18180	COG4948	Mandelate Racemase Muconate Lactonizing
XPE_18185	COG3250	beta-galactosidase activity
XPE_18195	COG1609	Transcriptional regulator
XPE_18205	COG1970	mechanosensitive ion channel activity
XPE_18230	COG0471	metal ion transport
XPE_18230	COG3273	potassium ion transport
XPE_18235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XPE_18240	COG2022	thiamine diphosphate biosynthetic process
XPE_18285	COG0189	ligase activity
XPE_18295	COG0745	RESPONSE REGULATOR receiver
XPE_18305	COG0237	dephospho-CoA kinase activity
XPE_18310	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XPE_18370	COG0045	succinate-CoA ligase (ADP-forming) activity
XPE_18375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XPE_18390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XPE_18390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XPE_18400	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XPE_18405	COG0564	pseudouridine synthase activity
XPE_18420	COG3011	Protein conserved in bacteria
XPE_18425	COG0840	transmembrane signaling receptor activity
XPE_18440	COG3387	PFAM Glycoside hydrolase 15-related
XPE_18445	COG1877	trehalose-phosphatase activity
XPE_18450	COG4771	TonB-dependent receptor
XPE_18490	COG1116	anion transmembrane transporter activity
XPE_18500	COG0542	response to heat
XPE_18505	COG4206	TonB-dependent receptor
XPE_18525	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XPE_18535	COG1492	cobalamin metabolic process
XPE_18545	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XPE_18570	COG0019	diaminopimelate decarboxylase activity
XPE_18580	COG2814	Major facilitator Superfamily
XPE_18585	COG4264	IucA IucC family
XPE_18595	COG4772	TonB-dependent receptor
XPE_18620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XPE_18620	COG4651	solute:proton antiporter activity
XPE_18660	COG0488	(ABC) transporter
XPE_18680	COG0657	acetylesterase activity
XPE_18680	COG2755	lipolytic protein G-D-S-L family
XPE_18700	COG0477	Major facilitator Superfamily
XPE_18715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XPE_18745	COG0217	transcriptional regulatory protein
XPE_18750	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XPE_18755	COG0632	four-way junction helicase activity
XPE_18760	COG3158	transport of potassium into the cell
XPE_18770	COG2255	four-way junction helicase activity
XPE_18775	COG0824	Thioesterase
XPE_18785	COG0848	biopolymer transport protein
XPE_18795	COG0823	Involved in the tonB-independent uptake of proteins
XPE_18800	COG2885	chlorophyll binding
XPE_18810	COG0602	queuosine metabolic process
XPE_18825	COG3920	Histidine kinase
XPE_18845	COG0840	transmembrane signaling receptor activity
XPE_18860	COG1187	pseudouridine synthase activity
XPE_18885	COG0514	ATP-dependent DNA helicase (RecQ)
XPE_18890	COG0783	Belongs to the Dps family
XPE_18895	COG1643	Atp-dependent helicase
XPE_18905	COG0837	glucose binding
XPE_18925	COG0535	radical SAM domain protein
XPE_18930	COG0535	radical SAM domain protein
XPE_18935	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XPE_18940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XPE_18950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XPE_18965	COG1215	transferase activity, transferring glycosyl groups
XPE_18970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XPE_18980	COG1199	ATP-dependent helicase activity
XPE_18985	COG1214	PFAM Peptidase M22, glycoprotease
XPE_18990	COG1397	ADP-ribosylglycohydrolase
XPE_19025	COG0189	ligase activity
XPE_19040	COG0835	chemotaxis
XPE_19045	COG0840	transmembrane signaling receptor activity
XPE_19080	COG1595	DNA-templated transcription, initiation
XPE_19085	COG2304	oxidoreductase activity
XPE_19090	COG1446	asparaginase
XPE_19095	COG3142	Participates in the control of copper homeostasis
XPE_19140	COG3537	Alpha-1,2-mannosidase
XPE_19150	COG1472	Belongs to the glycosyl hydrolase 3 family
XPE_19165	COG1388	LysM domain
XPE_19165	COG3858	chitin binding
XPE_19180	COG0837	glucose binding
XPE_19185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XPE_19195	COG0494	nUDIX hydrolase
XPE_19205	COG3956	TIGRFAM MazG family protein
XPE_19210	COG1742	UPF0060 membrane protein
XPE_19225	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XPE_19230	COG0509	glycine decarboxylation via glycine cleavage system
XPE_19255	COG1960	acyl-CoA dehydrogenase activity
XPE_19260	COG2267	carboxylic ester hydrolase activity
XPE_19265	COG1309	transcriptional regulator
XPE_19280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XPE_19285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XPE_19290	COG0463	Glycosyl transferase, family 2
XPE_19295	COG0517	IMP dehydrogenase activity
XPE_19295	COG0516	GMP reductase activity
XPE_19300	COG2982	Protein involved in outer membrane biogenesis
XPE_19305	COG1272	protein, Hemolysin III
XPE_19310	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XPE_19315	COG0739	heme binding
XPE_19320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XPE_19325	COG0626	cystathionine gamma-synthase activity
XPE_19330	COG0460	homoserine dehydrogenase
XPE_19330	COG0527	aspartate kinase activity
XPE_19345	COG1760	l-serine dehydratase
XPE_19365	COG2353	YceI-like domain
XPE_19370	COG2205	protein histidine kinase activity
XPE_19370	COG2198	Histidine kinase
XPE_19370	COG0784	Response regulator, receiver
XPE_19390	COG2814	Major facilitator Superfamily
XPE_19395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XPE_19405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XPE_19410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XPE_19415	COG0259	pyridoxamine-phosphate oxidase activity
XPE_19425	COG1842	Phage shock protein A
XPE_19450	COG0754	glutathionylspermidine amidase activity
XPE_19455	COG2814	Major facilitator Superfamily
XPE_19550	COG0531	amino acid
XPE_19555	COG2197	response regulator
XPE_19580	COG1113	amino acid transport
XPE_19590	COG1271	oxidase subunit
XPE_19595	COG1294	oxidase, subunit
XPE_19605	COG2239	Acts as a magnesium transporter
XPE_19615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XPE_19620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPE_19630	COG1660	Displays ATPase and GTPase activities
XPE_19635	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XPE_19640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPE_19655	COG1137	ATPase activity
XPE_19660	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XPE_19670	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XPE_19680	COG0271	Belongs to the BolA IbaG family
XPE_19685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XPE_19705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XPE_19715	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XPE_19725	COG0628	permease
XPE_19735	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XPE_19755	COG1555	photosystem II stabilization
XPE_19770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XPE_19775	COG1477	protein flavinylation
XPE_19800	COG3128	pkhd-type hydroxylase
XPE_19805	COG4774	siderophore transport
XPE_19815	COG0456	acetyltransferase
XPE_19820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XPE_19825	COG0719	Fe-S assembly protein
XPE_19830	COG0396	ATPase activity
XPE_19835	COG0719	Fe-S assembly protein
XPE_19840	COG1959	2 iron, 2 sulfur cluster binding
XPE_19850	COG0693	protein deglycase activity
XPE_19870	COG0739	heme binding
XPE_19885	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XPE_19915	COG0519	Catalyzes the synthesis of GMP from XMP
XPE_19925	COG1678	Uncharacterized ACR, COG1678
XPE_19930	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XPE_19935	COG0540	Belongs to the ATCase OTCase family
XPE_19940	COG1764	response to oxidative stress
XPE_19950	COG0384	phenazine biosynthesis protein PhzF
XPE_19955	COG0384	phenazine biosynthesis protein PhzF
XPE_19960	COG0527	aspartate kinase activity
XPE_19975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XPE_19990	COG0142	geranyltranstransferase activity
XPE_19995	COG0629	single-stranded DNA binding
XPE_20000	COG2203	Gaf domain
XPE_20000	COG5001	Diguanylate cyclase
XPE_20000	COG4251	negative regulation of phosphorylation
XPE_20000	COG3706	GGDEF domain
XPE_20005	COG1028	Short-chain dehydrogenase reductase Sdr
XPE_20005	COG3321	synthase
XPE_20005	COG0604	alcohol dehydrogenase
XPE_20010	COG2080	2 iron, 2 sulfur cluster binding
XPE_20015	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XPE_20020	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XPE_20025	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XPE_20065	COG2879	small protein
XPE_20070	COG1966	Carbon starvation protein
XPE_20075	COG1741	Belongs to the pirin family
XPE_20090	COG1741	Belongs to the pirin family
XPE_20105	COG1515	deoxyribonuclease V activity
XPE_20110	COG0588	phosphoglycerate mutase activity
XPE_20120	COG3590	peptidase
XPE_20125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XPE_20130	COG2201	protein-glutamate methylesterase activity
XPE_20135	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XPE_20140	COG2202	Pas domain
XPE_20140	COG2200	EAL domain
XPE_20140	COG2199	diguanylate cyclase activity
XPE_20145	COG0835	chemotaxis
XPE_20150	COG0840	transmembrane signaling receptor activity
XPE_20160	COG0643	Histidine kinase
XPE_20160	COG2198	Histidine kinase
XPE_20170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XPE_20180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XPE_20185	COG0745	RESPONSE REGULATOR receiver
XPE_20190	COG2205	protein histidine kinase activity
XPE_20200	COG4452	Inner membrane protein CreD
XPE_20225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XPE_20230	COG0735	belongs to the Fur family
XPE_20245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPE_20250	COG1538	Outer membrane efflux protein
XPE_20255	COG1309	transcriptional regulator
XPE_20270	COG2207	Transcriptional regulator
XPE_20280	COG0583	DNA-binding transcription factor activity
XPE_20285	COG2814	Major facilitator Superfamily
XPE_20290	COG0667	Aldo Keto reductase
XPE_20405	COG5001	Diguanylate cyclase
XPE_20405	COG5002	protein histidine kinase activity
XPE_20410	COG1187	pseudouridine synthase activity
XPE_20415	COG3706	GGDEF domain
XPE_20435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XPE_20440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
XPE_20445	COG0475	glutathione-regulated potassium exporter activity
XPE_20450	COG5000	phosphorelay sensor kinase activity
XPE_20450	COG5002	protein histidine kinase activity
XPE_20455	COG0745	RESPONSE REGULATOR receiver
XPE_20460	COG1538	Outer membrane efflux protein
XPE_20490	COG1132	(ABC) transporter
XPE_20530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XPE_20535	COG2155	Conserved Protein
XPE_20565	COG3118	belongs to the thioredoxin family
XPE_20575	COG0495	leucyl-tRNA aminoacylation
XPE_20590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XPE_20605	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XPE_20615	COG2968	Membrane
XPE_20620	COG0424	maF-like protein
XPE_20625	COG1530	ribonuclease E activity
XPE_20630	COG3164	Protein of unknown function
XPE_20640	COG0312	modulator of DNA gyrase
XPE_20645	COG3028	Belongs to the UPF0307 family
XPE_20650	COG0312	modulator of DNA gyrase
XPE_20660	COG4104	PAAR repeat-containing protein
XPE_20665	COG0142	geranyltranstransferase activity
XPE_20670	COG1722	exodeoxyribonuclease VII activity
XPE_20675	COG0037	tRNA processing
XPE_20685	COG1785	Belongs to the alkaline phosphatase family
XPE_20690	COG1301	dicarboxylic acid transport
XPE_20705	COG0791	NLP P60 protein
XPE_20710	COG0791	NLP P60 protein
XPE_20715	COG1047	Peptidyl-prolyl cis-trans
XPE_20720	COG2311	Membrane
XPE_20725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XPE_20730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XPE_20750	COG3590	peptidase
XPE_20760	COG3590	peptidase
XPE_20785	COG0489	protein tyrosine kinase activity
XPE_20795	COG0717	Belongs to the dCTP deaminase family
XPE_20820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XPE_20825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XPE_20845	COG0494	nUDIX hydrolase
XPE_20850	COG0433	COG0433 Predicted ATPase
XPE_20860	COG0688	phosphatidylethanolamine metabolic process
XPE_20870	COG2890	protein-(glutamine-N5) methyltransferase activity
XPE_20875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XPE_20880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XPE_20885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XPE_20900	COG0101	tRNA pseudouridine synthase activity
XPE_20905	COG0135	phosphoribosylanthranilate isomerase activity
XPE_20915	COG0133	tryptophan synthase activity
XPE_20925	COG0159	tryptophan synthase activity
XPE_20930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XPE_20935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XPE_20965	COG4221	oxidoreductase activity
XPE_20970	COG0149	triose-phosphate isomerase activity
XPE_20985	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPE_20990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPE_20995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPE_21000	COG0649	NAD binding
XPE_21005	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XPE_21010	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XPE_21015	COG1034	ATP synthesis coupled electron transport
XPE_21020	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XPE_21025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPE_21035	COG0713	ATP synthesis coupled electron transport
XPE_21050	COG1007	ATP synthesis coupled electron transport
XPE_21060	COG0779	Required for maturation of 30S ribosomal subunits
XPE_21065	COG0195	Participates in both transcription termination and antitermination
XPE_21070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XPE_21075	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XPE_21080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XPE_21085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XPE_21090	COG1185	polyribonucleotide nucleotidyltransferase activity
XPE_21120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XPE_21125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XPE_21135	COG2095	MarC family integral membrane protein
XPE_21145	COG1611	Belongs to the LOG family
XPE_21150	COG3275	phosphorelay sensor kinase activity
XPE_21195	COG0556	nucleotide-excision repair
XPE_21215	COG3505	Type IV secretory pathway VirD4
XPE_21235	COG2948	multi-organism process
XPE_21255	COG3702	type iv secretory pathway
XPE_21310	COG2801	Transposase and inactivated derivatives
XPE_21315	COG2963	transposase activity
XPE_21320	COG0366	Alpha amylase catalytic
XPE_21335	COG1082	Xylose isomerase domain protein TIM barrel
XPE_21360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XPE_21365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XPE_21370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
XPE_21375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XPE_21380	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XPE_21385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XPE_21385	COG0072	phenylalanine-tRNA ligase activity
XPE_21390	COG0776	regulation of translation
XPE_21435	COG0438	transferase activity, transferring glycosyl groups
XPE_21440	COG0438	transferase activity, transferring glycosyl groups
XPE_21475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XPE_21480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XPE_21485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XPE_21505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XPE_21515	COG1960	acyl-CoA dehydrogenase activity
XPE_21525	COG3040	lipid binding
XPE_21540	COG0322	excinuclease ABC activity
XPE_21555	COG4191	Histidine kinase
XPE_21555	COG0784	Response regulator, receiver
XPE_21565	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XPE_21570	COG1194	a g-specific adenine glycosylase
XPE_21580	COG0552	protein localization to endoplasmic reticulum
XPE_21590	COG3938	Belongs to the proline racemase family
XPE_21595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XPE_21610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XPE_21620	COG0006	proline dipeptidase activity
XPE_21635	COG0531	amino acid
XPE_21705	COG0326	Molecular chaperone. Has ATPase activity
XPE_21710	COG0742	ribosomal rna small subunit methyltransferase
XPE_21715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XPE_21730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XPE_21735	COG0405	Gamma-glutamyltransferase
XPE_21740	COG3291	Pkd domain containing protein
XPE_21745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate