locus-tag	class	description
PJW04_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PJW04_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PJW04_00020	COG0187	DNA topoisomerase II activity
PJW04_00030	COG0501	Belongs to the peptidase M48B family
PJW04_00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PJW04_00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PJW04_00120	COG0793	Belongs to the peptidase S41A family
PJW04_00125	COG4942	peptidase
PJW04_00135	COG2234	aminopeptidase activity
PJW04_00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PJW04_00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PJW04_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PJW04_00160	COG1064	alcohol dehydrogenase
PJW04_00170	COG0493	'glutamate synthase
PJW04_00175	COG0067	glutamate synthase
PJW04_00175	COG0069	glutamate synthase activity
PJW04_00175	COG0070	glutamate synthase
PJW04_00260	COG1205	dead DEAH box helicase
PJW04_00260	COG1111	helicase
PJW04_00265	COG1272	protein, Hemolysin III
PJW04_00285	COG0300	oxidoreductase activity
PJW04_00290	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_00305	COG2249	NAD(P)H dehydrogenase (quinone) activity
PJW04_00340	COG3237	CsbD-like
PJW04_00385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PJW04_00390	COG0477	Major facilitator Superfamily
PJW04_00430	COG0714	Associated with various cellular activities
PJW04_00475	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PJW04_00485	COG4772	TonB-dependent receptor
PJW04_00500	COG1012	belongs to the aldehyde dehydrogenase family
PJW04_00525	COG1304	FMN binding
PJW04_00540	COG1755	Isoprenylcysteine carboxyl methyltransferase
PJW04_00545	COG4585	Histidine kinase
PJW04_00550	COG2197	response regulator
PJW04_00570	COG3710	Transcriptional regulator
PJW04_00575	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PJW04_00585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PJW04_00660	COG0366	Alpha amylase catalytic
PJW04_00665	COG0366	Alpha amylase catalytic
PJW04_00670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PJW04_00685	COG2272	Belongs to the type-B carboxylesterase lipase family
PJW04_00690	COG0657	acetylesterase activity
PJW04_00690	COG2755	lipolytic protein G-D-S-L family
PJW04_00700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PJW04_00715	COG3507	Belongs to the glycosyl hydrolase 43 family
PJW04_00720	COG1609	Transcriptional regulator
PJW04_00725	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
PJW04_00730	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_00740	COG2755	lipolytic protein G-D-S-L family
PJW04_00750	COG3186	Phenylalanine-4-hydroxylase
PJW04_00755	COG1522	sequence-specific DNA binding
PJW04_00765	COG1752	Esterase of the alpha-beta hydrolase superfamily
PJW04_00770	COG1473	amidohydrolase
PJW04_00780	COG1119	ATPase activity
PJW04_00795	COG1125	glycine betaine transport
PJW04_00810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PJW04_00840	COG0489	protein tyrosine kinase activity
PJW04_00845	COG2062	phosphohistidine phosphatase, SixA
PJW04_00855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PJW04_00900	COG1968	undecaprenyl-diphosphatase activity
PJW04_00905	COG0174	glutamine synthetase
PJW04_00910	COG0347	Belongs to the P(II) protein family
PJW04_00915	COG0004	ammonium transporteR
PJW04_00920	COG3852	Histidine kinase
PJW04_00925	COG2204	response regulator
PJW04_00930	COG2032	superoxide dismutase activity
PJW04_00935	COG2032	superoxide dismutase activity
PJW04_00950	COG0183	Belongs to the thiolase family
PJW04_00985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PJW04_00990	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PJW04_00995	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PJW04_01010	COG0028	Belongs to the TPP enzyme family
PJW04_01015	COG4191	Histidine kinase
PJW04_01040	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PJW04_01055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PJW04_01060	COG3177	Filamentation induced by cAMP protein fic
PJW04_01065	COG0596	Alpha beta hydrolase
PJW04_01070	COG0727	PFAM Uncharacterised protein family (UPF0153)
PJW04_01075	COG0318	PFAM AMP-dependent synthetase and ligase
PJW04_01080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PJW04_01100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PJW04_01110	COG0564	pseudouridine synthase activity
PJW04_01130	COG1446	asparaginase
PJW04_01135	COG0339	signal peptide processing
PJW04_01165	COG0475	glutathione-regulated potassium exporter activity
PJW04_01170	COG0583	DNA-binding transcription factor activity
PJW04_01175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PJW04_01180	COG2224	Isocitrate lyase
PJW04_01210	COG4770	biotin carboxylase activity
PJW04_01215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PJW04_01220	COG1960	acyl-CoA dehydrogenase activity
PJW04_01280	COG0523	cobalamin synthesis protein
PJW04_01290	COG0697	spore germination
PJW04_01300	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PJW04_01305	COG1846	Transcriptional regulator
PJW04_01310	COG1764	response to oxidative stress
PJW04_01330	COG2130	NADP-dependent
PJW04_01345	COG1187	pseudouridine synthase activity
PJW04_01355	COG1643	Atp-dependent helicase
PJW04_01365	COG4807	Protein conserved in bacteria
PJW04_01375	COG2072	flavoprotein involved in K transport
PJW04_01395	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PJW04_01405	COG0583	DNA-binding transcription factor activity
PJW04_01445	COG2252	PERMEase
PJW04_01465	COG0084	hydrolase, TatD family'
PJW04_01480	COG0583	DNA-binding transcription factor activity
PJW04_01485	COG2814	Major facilitator Superfamily
PJW04_01495	COG2267	carboxylic ester hydrolase activity
PJW04_01500	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PJW04_01505	COG1902	pentaerythritol trinitrate reductase activity
PJW04_01525	COG0745	RESPONSE REGULATOR receiver
PJW04_01530	COG2205	protein histidine kinase activity
PJW04_01535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PJW04_01560	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PJW04_01565	COG0583	DNA-binding transcription factor activity
PJW04_01600	COG0702	epimerase
PJW04_01605	COG1733	regulation of RNA biosynthetic process
PJW04_01680	COG0129	dihydroxy-acid dehydratase activity
PJW04_01695	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PJW04_01750	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PJW04_01755	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PJW04_01780	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PJW04_01785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PJW04_01795	COG3485	protocatechuate 3,4-dioxygenase
PJW04_01800	COG3485	protocatechuate 3,4-dioxygenase
PJW04_01810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PJW04_01815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PJW04_01830	COG1414	Transcriptional regulator
PJW04_01840	COG0657	acetylesterase activity
PJW04_01850	COG0445	tRNA wobble uridine modification
PJW04_01860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PJW04_01885	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_01890	COG2267	carboxylic ester hydrolase activity
PJW04_01900	COG0156	8-amino-7-oxononanoate synthase activity
PJW04_01905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PJW04_01910	COG1040	competence protein
PJW04_01915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PJW04_02000	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PJW04_02085	COG3264	Mechanosensitive ion channel
PJW04_02085	COG1511	domain protein
PJW04_02090	COG1368	sulfuric ester hydrolase activity
PJW04_02095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PJW04_02100	COG2354	Protein conserved in bacteria
PJW04_02110	COG0297	glycogen (starch) synthase activity
PJW04_02115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PJW04_02120	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PJW04_02145	COG0702	epimerase
PJW04_02150	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_02180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PJW04_02185	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_02195	COG0513	Belongs to the DEAD box helicase family
PJW04_02205	COG0508	dehydrogenase complex catalyzes the overall conversion of
PJW04_02220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PJW04_02230	COG3483	tryptophan 2,3-dioxygenase activity
PJW04_02235	COG3104	oligopeptide transport
PJW04_02255	COG2852	Protein conserved in bacteria
PJW04_02260	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
PJW04_02275	COG1320	monovalent cation:proton antiporter activity
PJW04_02280	COG2212	antiporter activity
PJW04_02290	COG0651	ATP synthesis coupled electron transport
PJW04_02295	COG1006	Multisubunit Na H antiporter MnhC subunit
PJW04_02300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PJW04_02300	COG2111	Na H antiporter
PJW04_02320	COG3179	chitinase
PJW04_02340	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PJW04_02345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PJW04_02350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PJW04_02355	COG0456	acetyltransferase
PJW04_02360	COG1597	lipid kinase activity
PJW04_02390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PJW04_02395	COG0134	indole-3-glycerol-phosphate synthase activity
PJW04_02405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PJW04_02410	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PJW04_02420	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
PJW04_02430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PJW04_02445	COG1051	belongs to the nudix hydrolase family
PJW04_02485	COG0316	Belongs to the HesB IscA family
PJW04_02500	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PJW04_02525	COG2814	Major facilitator Superfamily
PJW04_02530	COG1289	transmembrane transporter activity
PJW04_02535	COG0151	Belongs to the GarS family
PJW04_02545	COG0138	bifunctional purine biosynthesis protein purh
PJW04_02550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PJW04_02555	COG2267	carboxylic ester hydrolase activity
PJW04_02560	COG2453	phosphatase
PJW04_02560	COG0671	phosphoesterase, PA-phosphatase related
PJW04_02585	COG4589	Belongs to the CDS family
PJW04_02590	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PJW04_02610	COG2264	protein methyltransferase activity
PJW04_02630	COG0439	Biotin carboxylase
PJW04_02640	COG0511	ligase activity, forming carbon-carbon bonds
PJW04_02645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PJW04_02655	COG1324	tolerance protein
PJW04_02665	COG2356	endonuclease I
PJW04_02680	COG0459	protein refolding
PJW04_02695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PJW04_02710	COG3386	PFAM SMP-30 Gluconolaconase
PJW04_02720	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PJW04_02725	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PJW04_02750	COG0778	Nitroreductase
PJW04_02755	COG2353	YceI-like domain
PJW04_02785	COG3052	prosthetic group binding
PJW04_02810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PJW04_02820	COG1802	Transcriptional regulator
PJW04_02825	COG0546	phosphoglycolate phosphatase activity
PJW04_03005	COG4221	oxidoreductase activity
PJW04_03015	COG0435	Glutathione S-transferase
PJW04_03070	COG1959	2 iron, 2 sulfur cluster binding
PJW04_03095	COG0697	spore germination
PJW04_03110	COG1113	amino acid transport
PJW04_03120	COG0598	Magnesium transport protein CorA
PJW04_03130	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
PJW04_03165	COG0840	transmembrane signaling receptor activity
PJW04_03170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PJW04_03170	COG5297	Belongs to the glycosyl hydrolase family 6
PJW04_03175	COG0659	secondary active sulfate transmembrane transporter activity
PJW04_03190	COG2943	transferase activity, transferring hexosyl groups
PJW04_03200	COG3275	phosphorelay sensor kinase activity
PJW04_03210	COG0181	hydroxymethylbilane synthase activity
PJW04_03245	COG1505	serine-type exopeptidase activity
PJW04_03250	COG0436	Aminotransferase
PJW04_03260	COG2832	Protein of unknown function (DUF454)
PJW04_03270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PJW04_03280	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PJW04_03285	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PJW04_03290	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PJW04_03320	COG5001	Diguanylate cyclase
PJW04_03320	COG3300	MHYT domain
PJW04_03325	COG0308	aminopeptidase N
PJW04_03360	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PJW04_03370	COG3284	Transcriptional regulator
PJW04_03375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PJW04_03380	COG1077	Cell shape determining protein MreB Mrl
PJW04_03385	COG1792	Involved in formation and maintenance of cell shape
PJW04_03400	COG0772	Belongs to the SEDS family
PJW04_03415	COG2951	lytic endotransglycosylase activity
PJW04_03420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PJW04_03425	COG1686	Belongs to the peptidase S11 family
PJW04_03435	COG2921	Belongs to the UPF0250 family
PJW04_03440	COG0321	lipoyl(octanoyl) transferase activity
PJW04_03445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PJW04_03460	COG0583	DNA-binding transcription factor activity
PJW04_03470	COG1051	belongs to the nudix hydrolase family
PJW04_03470	COG1056	cytidyltransferase-related domain
PJW04_03505	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PJW04_03510	COG0673	inositol 2-dehydrogenase activity
PJW04_03515	COG2823	Periplasmic or secreted lipoprotein
PJW04_03520	COG4251	negative regulation of phosphorylation
PJW04_03525	COG0784	Response regulator, receiver
PJW04_03530	COG4191	Histidine kinase
PJW04_03535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PJW04_03590	COG1459	type II secretion system
PJW04_03610	COG4795	General secretion pathway protein
PJW04_03635	COG2188	Transcriptional regulator
PJW04_03645	COG1609	Transcriptional regulator
PJW04_03650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PJW04_03655	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PJW04_03670	COG0617	tRNA 3'-terminal CCA addition
PJW04_03675	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PJW04_03680	COG1012	belongs to the aldehyde dehydrogenase family
PJW04_03685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PJW04_03715	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PJW04_03725	COG2205	protein histidine kinase activity
PJW04_03755	COG3791	Glutathione-dependent formaldehyde-activating
PJW04_03770	COG0488	(ABC) transporter
PJW04_03780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PJW04_03785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PJW04_03795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PJW04_03795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PJW04_03815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PJW04_03820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PJW04_03825	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PJW04_03845	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PJW04_03850	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
PJW04_03860	COG2205	protein histidine kinase activity
PJW04_03865	COG0745	RESPONSE REGULATOR receiver
PJW04_03875	COG0277	FAD linked oxidase domain protein
PJW04_03880	COG1988	membrane-bound metal-dependent
PJW04_03885	COG0792	nuclease activity
PJW04_03925	COG0275	rRNA processing
PJW04_03930	COG3116	cell division
PJW04_03940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PJW04_03945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PJW04_03950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PJW04_03960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PJW04_03965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PJW04_03970	COG1181	Belongs to the D-alanine--D-alanine ligase family
PJW04_03975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PJW04_03990	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PJW04_04000	COG0739	heme binding
PJW04_04005	COG0653	protein targeting
PJW04_04010	COG0494	nUDIX hydrolase
PJW04_04020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PJW04_04030	COG0604	alcohol dehydrogenase
PJW04_04030	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_04030	COG3321	synthase
PJW04_04050	COG0366	Alpha amylase catalytic
PJW04_04075	COG2226	methyltransferase
PJW04_04080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PJW04_04090	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PJW04_04130	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PJW04_04140	COG4106	trans-aconitate 2-methyltransferase activity
PJW04_04145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PJW04_04155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PJW04_04160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PJW04_04165	COG0667	Aldo Keto reductase
PJW04_04175	COG4771	TonB-dependent receptor
PJW04_04195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PJW04_04200	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PJW04_04210	COG2175	clavaminate synthase activity
PJW04_04220	COG4181	ATPase activity
PJW04_04235	COG0642	Histidine kinase
PJW04_04245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PJW04_04265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PJW04_04270	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PJW04_04285	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PJW04_04290	COG2967	ApaG domain
PJW04_04295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PJW04_04300	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PJW04_04305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PJW04_04310	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PJW04_04315	COG0123	including yeast histone deacetylase and acetoin utilization protein
PJW04_04320	COG2096	Adenosyltransferase
PJW04_04330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PJW04_04335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PJW04_04365	COG3384	dioxygenase
PJW04_04370	COG0583	DNA-binding transcription factor activity
PJW04_04375	COG0318	PFAM AMP-dependent synthetase and ligase
PJW04_04385	COG1024	Enoyl-CoA hydratase
PJW04_04405	COG3386	PFAM SMP-30 Gluconolaconase
PJW04_04415	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PJW04_04435	COG0697	spore germination
PJW04_04445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PJW04_04460	COG0745	RESPONSE REGULATOR receiver
PJW04_04470	COG2197	response regulator
PJW04_04480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PJW04_04490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PJW04_04495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PJW04_04505	COG0583	DNA-binding transcription factor activity
PJW04_04510	COG3634	alkyl hydroperoxide reductase activity
PJW04_04520	COG2890	protein-(glutamine-N5) methyltransferase activity
PJW04_04540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PJW04_04540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PJW04_04555	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PJW04_04580	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
PJW04_04595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PJW04_04600	COG1404	Belongs to the peptidase S8 family
PJW04_04605	COG1404	Belongs to the peptidase S8 family
PJW04_04610	COG1404	Belongs to the peptidase S8 family
PJW04_04615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PJW04_04640	COG1295	ribonuclease BN
PJW04_04645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PJW04_04650	COG1254	Belongs to the acylphosphatase family
PJW04_04665	COG0521	Mo-molybdopterin cofactor biosynthetic process
PJW04_04675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PJW04_04680	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PJW04_04690	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PJW04_04695	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PJW04_04705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PJW04_04710	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PJW04_04715	COG0193	aminoacyl-tRNA hydrolase activity
PJW04_04720	COG0012	GTP binding
PJW04_04740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PJW04_04755	COG0250	Participates in transcription elongation, termination and antitermination
PJW04_04760	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PJW04_04765	COG0081	regulation of translation
PJW04_04770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PJW04_04775	COG0222	ribosome binding
PJW04_04780	COG0085	RNA polymerase activity
PJW04_04785	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PJW04_04790	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PJW04_04795	COG0049	tRNA binding
PJW04_04800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PJW04_04805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PJW04_04815	COG0051	transcription antitermination factor activity, RNA binding
PJW04_04820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PJW04_04825	COG0088	Forms part of the polypeptide exit tunnel
PJW04_04835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PJW04_04840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PJW04_04850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PJW04_04855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PJW04_04860	COG0255	Belongs to the universal ribosomal protein uL29 family
PJW04_04865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PJW04_04880	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PJW04_04885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PJW04_04890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PJW04_04895	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PJW04_04900	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PJW04_04910	COG1841	ribosomal large subunit assembly
PJW04_04915	COG0200	Binds to the 23S rRNA
PJW04_04920	COG0201	protein transport
PJW04_04945	COG0203	ribosomal protein L17
PJW04_04950	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PJW04_04965	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PJW04_04975	COG0154	amidase activity
PJW04_04985	COG1217	gtp-binding protein TYPA
PJW04_04990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PJW04_04995	COG0039	L-malate dehydrogenase activity
PJW04_05000	COG0625	glutathione transferase activity
PJW04_05015	COG1902	pentaerythritol trinitrate reductase activity
PJW04_05015	COG0446	pyridine nucleotide-disulphide oxidoreductase
PJW04_05020	COG0604	alcohol dehydrogenase
PJW04_05025	COG2885	chlorophyll binding
PJW04_05045	COG0156	8-amino-7-oxononanoate synthase activity
PJW04_05050	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PJW04_05055	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PJW04_05060	COG4208	sulfate ABC transporter
PJW04_05065	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PJW04_05075	COG1063	alcohol dehydrogenase
PJW04_05095	COG0406	alpha-ribazole phosphatase activity
PJW04_05100	COG0285	dihydrofolate synthase activity
PJW04_05120	COG2833	Protein of unknown function (DUF455)
PJW04_05125	COG3291	Pkd domain containing protein
PJW04_05135	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PJW04_05140	COG0671	phosphoesterase, PA-phosphatase related
PJW04_05145	COG0438	transferase activity, transferring glycosyl groups
PJW04_05155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PJW04_05170	COG4783	chaperone-mediated protein folding
PJW04_05185	COG0473	3-isopropylmalate dehydrogenase activity
PJW04_05215	COG3852	Histidine kinase
PJW04_05225	COG0544	peptidyl-prolyl cis-trans isomerase activity
PJW04_05235	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PJW04_05265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PJW04_05275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PJW04_05285	COG0328	RNA-DNA hybrid ribonuclease activity
PJW04_05290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PJW04_05295	COG0631	protein serine/threonine phosphatase activity
PJW04_05355	COG0859	PFAM glycosyl transferase family 9
PJW04_05360	COG3642	lipopolysaccharide core region biosynthetic process
PJW04_05365	COG1234	tRNA 3'-trailer cleavage
PJW04_05370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PJW04_05380	COG0315	cyclic pyranopterin monophosphate synthase activity
PJW04_05385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PJW04_05390	COG0314	molybdopterin synthase activity
PJW04_05475	COG2003	Belongs to the UPF0758 family
PJW04_05520	COG4680	protein conserved in bacteria
PJW04_05545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PJW04_05550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PJW04_05555	COG0537	adenosine 5'-monophosphoramidase activity
PJW04_05575	COG0714	Associated with various cellular activities
PJW04_05590	COG0424	maF-like protein
PJW04_05600	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PJW04_05605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PJW04_05635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PJW04_05640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PJW04_05670	COG3829	transcription factor binding
PJW04_05710	COG2373	Large extracellular alpha-helical protein
PJW04_05725	COG4953	penicillin-binding protein 1C
PJW04_05735	COG0678	peroxiredoxin activity
PJW04_05755	COG0330	HflC and HflK could
PJW04_05760	COG0330	HflC and HflK could
PJW04_05770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PJW04_05775	COG0308	aminopeptidase N
PJW04_05785	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_05790	COG1309	transcriptional regulator
PJW04_05820	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
PJW04_05850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PJW04_05860	COG3387	PFAM Glycoside hydrolase 15-related
PJW04_05865	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_05870	COG3537	Alpha-1,2-mannosidase
PJW04_05880	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_05890	COG0492	ferredoxin-NADP+ reductase activity
PJW04_05915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PJW04_05920	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
PJW04_05925	COG2080	2 iron, 2 sulfur cluster binding
PJW04_05960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PJW04_05975	COG0587	DNA-directed DNA polymerase activity
PJW04_05990	COG1297	OPT oligopeptide transporter protein
PJW04_06005	COG0823	Involved in the tonB-independent uptake of proteins
PJW04_06005	COG1506	peptidase
PJW04_06020	COG1917	Cupin 2, conserved barrel domain protein
PJW04_06020	COG2207	Transcriptional regulator
PJW04_06045	COG0753	catalase activity
PJW04_06050	COG0656	L-ascorbic acid biosynthetic process
PJW04_06055	COG2272	Belongs to the type-B carboxylesterase lipase family
PJW04_06060	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PJW04_06060	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PJW04_06085	COG2814	Major facilitator Superfamily
PJW04_06100	COG2194	sulfuric ester hydrolase activity
PJW04_06115	COG0745	RESPONSE REGULATOR receiver
PJW04_06120	COG0642	Histidine kinase
PJW04_06130	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PJW04_06135	COG2894	cell division
PJW04_06140	COG0850	regulation of cytokinetic process
PJW04_06150	COG4585	Histidine kinase
PJW04_06155	COG2197	response regulator
PJW04_06170	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PJW04_06195	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PJW04_06215	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PJW04_06230	COG1595	DNA-templated transcription, initiation
PJW04_06240	COG1946	Acyl-CoA thioesterase
PJW04_06245	COG1024	Enoyl-CoA hydratase
PJW04_06255	COG0824	Thioesterase
PJW04_06260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PJW04_06265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PJW04_06270	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PJW04_06275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PJW04_06280	COG0268	Binds directly to 16S ribosomal RNA
PJW04_06290	COG0196	riboflavin kinase activity
PJW04_06295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PJW04_06300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PJW04_06305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PJW04_06320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PJW04_06325	COG1845	cytochrome c oxidase, subunit III
PJW04_06330	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PJW04_06345	COG3152	Membrane
PJW04_06355	COG2207	Transcriptional regulator
PJW04_06360	COG0326	Molecular chaperone. Has ATPase activity
PJW04_06370	COG1366	Belongs to the anti-sigma-factor antagonist family
PJW04_06375	COG1366	Belongs to the anti-sigma-factor antagonist family
PJW04_06380	COG2172	sigma factor antagonist activity
PJW04_06405	COG4771	TonB-dependent receptor
PJW04_06415	COG5507	3-demethylubiquinone-9 3-methyltransferase
PJW04_06420	COG2205	protein histidine kinase activity
PJW04_06430	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PJW04_06435	COG2205	protein histidine kinase activity
PJW04_06435	COG3437	response regulator, receiver
PJW04_06435	COG3850	Histidine kinase
PJW04_06435	COG4999	Histidine kinase
PJW04_06440	COG0784	Response regulator, receiver
PJW04_06440	COG4191	Histidine kinase
PJW04_06460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PJW04_06465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PJW04_06475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PJW04_06480	COG0228	four-way junction DNA binding
PJW04_06485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PJW04_06490	COG0336	Belongs to the RNA methyltransferase TrmD family
PJW04_06495	COG0335	large ribosomal subunit rRNA binding
PJW04_06500	COG0534	Mate efflux family protein
PJW04_06520	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PJW04_06530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PJW04_06540	COG3483	tryptophan 2,3-dioxygenase activity
PJW04_06550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PJW04_06555	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_06565	COG0840	transmembrane signaling receptor activity
PJW04_06580	COG3250	beta-galactosidase activity
PJW04_06585	COG3867	Arabinogalactan endo-beta-1,4-galactanase
PJW04_06605	COG1960	acyl-CoA dehydrogenase activity
PJW04_06610	COG1024	Enoyl-CoA hydratase
PJW04_06630	COG1024	Enoyl-CoA hydratase
PJW04_06630	COG1250	3-hydroxyacyl-CoA dehydrogenase
PJW04_06645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PJW04_06650	COG0481	GTPase activity
PJW04_06665	COG0571	ribonuclease III activity
PJW04_06670	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PJW04_06675	COG1381	Involved in DNA repair and RecF pathway recombination
PJW04_06685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PJW04_06690	COG2954	triphosphatase activity
PJW04_06695	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PJW04_06700	COG1233	COG1233 Phytoene dehydrogenase and related
PJW04_06705	COG3046	protein related to deoxyribodipyrimidine photolyase
PJW04_06710	COG1472	Belongs to the glycosyl hydrolase 3 family
PJW04_06715	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PJW04_06720	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PJW04_06725	COG1278	Cold shock
PJW04_06730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PJW04_06740	COG1201	RNA secondary structure unwinding
PJW04_06745	COG1793	dna ligase
PJW04_06755	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PJW04_06755	COG1793	dna ligase
PJW04_06790	COG0183	Belongs to the thiolase family
PJW04_06815	COG1451	nucleotide metabolic process
PJW04_06820	COG5487	UPF0391 membrane protein
PJW04_06830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PJW04_06845	COG1077	Cell shape determining protein MreB Mrl
PJW04_06850	COG1047	Peptidyl-prolyl cis-trans
PJW04_06865	COG1902	pentaerythritol trinitrate reductase activity
PJW04_06870	COG2814	Major facilitator Superfamily
PJW04_06905	COG0392	lysyltransferase activity
PJW04_06905	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PJW04_06915	COG0251	oxidation-reduction process
PJW04_06920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PJW04_06935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PJW04_06960	COG1595	DNA-templated transcription, initiation
PJW04_06975	COG2878	Part of a membrane complex involved in electron transport
PJW04_06985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PJW04_06985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PJW04_07005	COG0346	lactoylglutathione lyase activity
PJW04_07020	COG0833	amino acid
PJW04_07025	COG2040	homocysteine
PJW04_07035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PJW04_07055	COG1695	Transcriptional regulator
PJW04_07075	COG1981	membrane
PJW04_07090	COG0825	malonyl-CoA metabolic process
PJW04_07105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PJW04_07110	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PJW04_07115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PJW04_07120	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PJW04_07135	COG0750	zinc metalloprotease
PJW04_07140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PJW04_07145	COG0575	Belongs to the CDS family
PJW04_07150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PJW04_07155	COG0233	cytoplasmic translational termination
PJW04_07160	COG0528	UMP kinase activity
PJW04_07170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PJW04_07175	COG0052	Belongs to the universal ribosomal protein uS2 family
PJW04_07215	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PJW04_07225	COG1393	Belongs to the ArsC family
PJW04_07230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PJW04_07235	COG0367	asparagine synthase
PJW04_07245	COG4774	siderophore transport
PJW04_07260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PJW04_07285	COG1566	PFAM secretion protein HlyD family protein
PJW04_07290	COG2814	Major facilitator Superfamily
PJW04_07355	COG0339	signal peptide processing
PJW04_07360	COG0386	Belongs to the glutathione peroxidase family
PJW04_07420	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PJW04_07425	COG0084	hydrolase, TatD family'
PJW04_07440	COG1960	acyl-CoA dehydrogenase activity
PJW04_07455	COG0367	asparagine synthase
PJW04_07465	COG0305	Participates in initiation and elongation during chromosome replication
PJW04_07470	COG0415	Belongs to the DNA photolyase family
PJW04_07480	COG0583	DNA-binding transcription factor activity
PJW04_07525	COG3706	GGDEF domain
PJW04_07565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PJW04_07580	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PJW04_07590	COG0497	DNA recombination
PJW04_07595	COG1420	regulation of RNA biosynthetic process
PJW04_07600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PJW04_07605	COG0443	Heat shock 70 kDa protein
PJW04_07610	COG0484	heat shock protein binding
PJW04_07615	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PJW04_07645	COG0583	DNA-binding transcription factor activity
PJW04_07650	COG1132	(ABC) transporter
PJW04_07685	COG2850	peptidyl-arginine hydroxylation
PJW04_07705	COG1253	flavin adenine dinucleotide binding
PJW04_07735	COG1131	(ABC) transporter
PJW04_07740	COG1725	Transcriptional regulator
PJW04_07750	COG0386	Belongs to the glutathione peroxidase family
PJW04_07770	COG2900	Belongs to the SlyX family
PJW04_07795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PJW04_07805	COG0646	methionine synthase
PJW04_07805	COG1410	methionine synthase
PJW04_07810	COG0646	methionine synthase
PJW04_07810	COG1410	methionine synthase
PJW04_07815	COG2226	methyltransferase
PJW04_07840	COG0557	exoribonuclease II activity
PJW04_07850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PJW04_07860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PJW04_07870	COG0704	Plays a role in the regulation of phosphate uptake
PJW04_07875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PJW04_07880	COG0581	inorganic phosphate transmembrane transporter activity
PJW04_07885	COG0573	inorganic phosphate transmembrane transporter activity
PJW04_07890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PJW04_07915	COG0659	secondary active sulfate transmembrane transporter activity
PJW04_07920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PJW04_07930	COG1024	Enoyl-CoA hydratase
PJW04_07940	COG0494	nUDIX hydrolase
PJW04_07985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PJW04_07985	COG0116	Belongs to the methyltransferase superfamily
PJW04_07990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PJW04_08005	COG0667	Aldo Keto reductase
PJW04_08015	COG2925	Exonuclease
PJW04_08025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PJW04_08030	COG3844	kynureninase activity
PJW04_08040	COG0662	Cupin 2, conserved barrel domain protein
PJW04_08045	COG0288	reversible hydration of carbon dioxide
PJW04_08115	COG0017	Asparaginyl-tRNA synthetase
PJW04_08120	COG0316	Belongs to the HesB IscA family
PJW04_08125	COG0360	Binds together with S18 to 16S ribosomal RNA
PJW04_08130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PJW04_08135	COG0359	binds to the 23S rRNA
PJW04_08145	COG3115	cell septum assembly
PJW04_08155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PJW04_08160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PJW04_08165	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
PJW04_08180	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PJW04_08190	COG4993	Dehydrogenase
PJW04_08200	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PJW04_08210	COG2986	histidine ammonia-lyase
PJW04_08215	COG1228	amidohydrolase
PJW04_08255	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
PJW04_08260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PJW04_08265	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PJW04_08270	COG0077	Prephenate dehydratase
PJW04_08270	COG1605	Chorismate mutase
PJW04_08275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PJW04_08290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PJW04_08295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PJW04_08300	COG0583	DNA-binding transcription factor activity
PJW04_08315	COG0840	transmembrane signaling receptor activity
PJW04_08350	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PJW04_08355	COG4191	Histidine kinase
PJW04_08355	COG0784	Response regulator, receiver
PJW04_08370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PJW04_08380	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PJW04_08390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PJW04_08405	COG1595	DNA-templated transcription, initiation
PJW04_08455	COG2244	polysaccharide biosynthetic process
PJW04_08460	COG1442	glycosyl transferase family 8
PJW04_08460	COG1216	Glycosyl transferase, family 2
PJW04_08485	COG2264	protein methyltransferase activity
PJW04_08495	COG0438	transferase activity, transferring glycosyl groups
PJW04_08515	COG1136	(ABC) transporter
PJW04_08520	COG1132	(ABC) transporter
PJW04_08525	COG2271	Major facilitator Superfamily
PJW04_08530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PJW04_08545	COG1253	flavin adenine dinucleotide binding
PJW04_08555	COG0306	phosphate transporter
PJW04_08580	COG0504	CTP synthase activity
PJW04_08595	COG0148	phosphopyruvate hydratase activity
PJW04_08600	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PJW04_08605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PJW04_08610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PJW04_08615	COG0585	pseudouridine synthase activity
PJW04_08620	COG2840	Smr protein MutS2
PJW04_08625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PJW04_08630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PJW04_08635	COG1238	metal cluster binding
PJW04_08650	COG1534	Rna-binding protein
PJW04_08655	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PJW04_08665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PJW04_08670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PJW04_08680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PJW04_08685	COG1546	Belongs to the CinA family
PJW04_08695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PJW04_08700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PJW04_08710	COG2137	regulation of response to DNA damage stimulus
PJW04_08715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PJW04_08720	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PJW04_08860	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
PJW04_08915	COG3179	chitinase
PJW04_08965	COG0740	serine-type endopeptidase activity
PJW04_09070	COG0582	viral genome integration into host DNA
PJW04_09080	COG1741	Belongs to the pirin family
PJW04_09085	COG0583	DNA-binding transcription factor activity
PJW04_09110	COG0351	phosphomethylpyrimidine kinase
PJW04_09125	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PJW04_09130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PJW04_09145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PJW04_09155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PJW04_09160	COG3734	2-keto-3-deoxy-galactonokinase
PJW04_09170	COG4948	Mandelate Racemase Muconate Lactonizing
PJW04_09175	COG0800	Aldolase
PJW04_09210	COG1501	Belongs to the glycosyl hydrolase 31 family
PJW04_09220	COG1070	Carbohydrate kinase
PJW04_09225	COG2115	Belongs to the xylose isomerase family
PJW04_09230	COG0477	Major facilitator Superfamily
PJW04_09245	COG0860	N-Acetylmuramoyl-L-alanine amidase
PJW04_09250	COG1469	GTP cyclohydrolase I activity
PJW04_09270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PJW04_09275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PJW04_09280	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PJW04_09285	COG0166	Belongs to the GPI family
PJW04_09305	COG1472	Belongs to the glycosyl hydrolase 3 family
PJW04_09320	COG4251	negative regulation of phosphorylation
PJW04_09320	COG3706	GGDEF domain
PJW04_09320	COG2203	Gaf domain
PJW04_09320	COG5001	Diguanylate cyclase
PJW04_09325	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PJW04_09330	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PJW04_09340	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PJW04_09345	COG0671	phosphoesterase, PA-phosphatase related
PJW04_09355	COG1794	racemase activity, acting on amino acids and derivatives
PJW04_09365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PJW04_09370	COG0167	dihydroorotate dehydrogenase activity
PJW04_09385	COG1012	belongs to the aldehyde dehydrogenase family
PJW04_09415	COG3210	domain, Protein
PJW04_09450	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
PJW04_09455	COG0527	aspartate kinase activity
PJW04_09455	COG0460	homoserine dehydrogenase
PJW04_09470	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PJW04_09480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PJW04_09485	COG0124	histidyl-tRNA synthetase
PJW04_09495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PJW04_09500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PJW04_09505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PJW04_09510	COG0131	Imidazoleglycerol-phosphate dehydratase
PJW04_09510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PJW04_09515	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PJW04_09520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PJW04_09525	COG0107	imidazoleglycerol-phosphate synthase activity
PJW04_09530	COG0140	phosphoribosyl-ATP diphosphatase activity
PJW04_09530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PJW04_09545	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
PJW04_09550	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PJW04_09555	COG0235	Class ii aldolase
PJW04_09560	COG0531	amino acid
PJW04_09565	COG0531	amino acid
PJW04_09575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PJW04_09580	COG0277	FAD linked oxidase domain protein
PJW04_09600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PJW04_09645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PJW04_09650	COG2258	MOSC domain
PJW04_09655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PJW04_09660	COG0505	Belongs to the CarA family
PJW04_09670	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PJW04_09675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PJW04_09685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PJW04_09695	COG3279	Response regulator of the LytR AlgR family
PJW04_09705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PJW04_09715	COG2205	protein histidine kinase activity
PJW04_09715	COG2198	Histidine kinase
PJW04_09715	COG0784	Response regulator, receiver
PJW04_09720	COG2205	protein histidine kinase activity
PJW04_09720	COG0784	Response regulator, receiver
PJW04_09720	COG2198	Histidine kinase
PJW04_09725	COG1024	Enoyl-CoA hydratase
PJW04_09730	COG0318	PFAM AMP-dependent synthetase and ligase
PJW04_09765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PJW04_09775	COG2201	protein-glutamate methylesterase activity
PJW04_09780	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
PJW04_09790	COG0840	transmembrane signaling receptor activity
PJW04_09800	COG0835	chemotaxis
PJW04_09815	COG0840	transmembrane signaling receptor activity
PJW04_09820	COG0840	transmembrane signaling receptor activity
PJW04_09830	COG0840	transmembrane signaling receptor activity
PJW04_09840	COG0840	transmembrane signaling receptor activity
PJW04_09845	COG0840	transmembrane signaling receptor activity
PJW04_09850	COG0840	transmembrane signaling receptor activity
PJW04_09855	COG0840	transmembrane signaling receptor activity
PJW04_09865	COG0840	transmembrane signaling receptor activity
PJW04_09895	COG0745	RESPONSE REGULATOR receiver
PJW04_09905	COG0835	chemotaxis
PJW04_09915	COG1360	Flagellar Motor Protein
PJW04_09920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PJW04_09995	COG0643	Histidine kinase
PJW04_09995	COG0784	Response regulator, receiver
PJW04_09995	COG2198	Histidine kinase
PJW04_10050	COG1684	flagellar biosynthetic protein fliR
PJW04_10070	COG3190	flagellar
PJW04_10120	COG1677	Flagellar hook-basal body complex protein FliE
PJW04_10155	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_10160	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_10165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PJW04_10185	COG2201	protein-glutamate methylesterase activity
PJW04_10215	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PJW04_10220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PJW04_10230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PJW04_10240	COG1705	Flagellar rod assembly protein muramidase FlgJ
PJW04_10240	COG3951	Flagellar rod assembly protein muramidase FlgJ
PJW04_10245	COG1706	bacterial-type flagellum-dependent cell motility
PJW04_10250	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PJW04_10265	COG4787	bacterial-type flagellum-dependent cell motility
PJW04_10275	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PJW04_10280	COG1558	bacterial-type flagellum-dependent cell motility
PJW04_10290	COG0784	Response regulator, receiver
PJW04_10290	COG0835	chemotaxis
PJW04_10310	COG5002	protein histidine kinase activity
PJW04_10345	COG2915	High frequency lysogenization protein hflD homolog
PJW04_10350	COG0482	sulfurtransferase activity
PJW04_10365	COG0542	response to heat
PJW04_10375	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PJW04_10390	COG0492	ferredoxin-NADP+ reductase activity
PJW04_10395	COG1674	ftsk spoiiie
PJW04_10405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PJW04_10420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PJW04_10425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PJW04_10430	COG0183	Belongs to the thiolase family
PJW04_10435	COG1024	Enoyl-CoA hydratase
PJW04_10435	COG1250	3-hydroxyacyl-CoA dehydrogenase
PJW04_10450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PJW04_10460	COG1426	Protein conserved in bacteria
PJW04_10470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PJW04_10475	COG1160	GTP binding
PJW04_10480	COG0303	'Molybdopterin
PJW04_10485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PJW04_10525	COG0708	Exodeoxyribonuclease III
PJW04_10535	COG0303	'Molybdopterin
PJW04_10540	COG0746	molybdenum cofactor guanylyltransferase activity
PJW04_10565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PJW04_10565	COG1648	precorrin-2 dehydrogenase activity
PJW04_10575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PJW04_10580	COG2223	nitrite transmembrane transporter activity
PJW04_10585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PJW04_10595	COG0243	molybdopterin cofactor binding
PJW04_10610	COG3685	Protein conserved in bacteria
PJW04_10625	COG5001	Diguanylate cyclase
PJW04_10640	COG4566	intracellular signal transduction
PJW04_10675	COG3275	phosphorelay sensor kinase activity
PJW04_10680	COG3279	Response regulator of the LytR AlgR family
PJW04_10820	COG0631	protein serine/threonine phosphatase activity
PJW04_10825	COG0515	serine threonine protein kinase
PJW04_10855	COG1858	cytochrome C peroxidase
PJW04_10870	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PJW04_10885	COG4585	Histidine kinase
PJW04_10890	COG2197	response regulator
PJW04_10955	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PJW04_11015	COG0010	Belongs to the arginase family
PJW04_11020	COG2986	histidine ammonia-lyase
PJW04_11025	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PJW04_11030	COG2188	Transcriptional regulator
PJW04_11050	COG2871	sodium ion transport
PJW04_11075	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PJW04_11100	COG2217	Heavy metal translocating P-type atpase
PJW04_11105	COG2217	Heavy metal translocating P-type atpase
PJW04_11120	COG1063	alcohol dehydrogenase
PJW04_11235	COG0640	Transcriptional regulator
PJW04_11265	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_11275	COG1073	alpha beta
PJW04_11275	COG2226	methyltransferase
PJW04_11290	COG0363	glucosamine-6-phosphate deaminase activity
PJW04_11320	COG0596	Alpha beta hydrolase
PJW04_11335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PJW04_11340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PJW04_11355	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PJW04_11355	COG0316	Belongs to the HesB IscA family
PJW04_11360	COG2154	pterin-4-alpha-carbinolamine dehydratase
PJW04_11370	COG0428	transporter
PJW04_11375	COG3064	Membrane
PJW04_11385	COG1530	ribonuclease E activity
PJW04_11395	COG1054	Belongs to the UPF0176 family
PJW04_11415	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PJW04_11425	COG0582	viral genome integration into host DNA
PJW04_11500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PJW04_11505	COG0322	excinuclease ABC activity
PJW04_11515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PJW04_11520	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PJW04_11525	COG1663	tetraacyldisaccharide 4'-kinase activity
PJW04_11530	COG1132	(ABC) transporter
PJW04_11540	COG0811	peptide transport
PJW04_11555	COG1136	(ABC) transporter
PJW04_11560	COG4591	ABC-type transport system involved in lipoprotein release permease component
PJW04_11570	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PJW04_11575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PJW04_11590	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PJW04_11605	COG0354	folic acid binding
PJW04_11615	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PJW04_11620	COG0837	glucose binding
PJW04_11625	COG0363	glucosamine-6-phosphate deaminase activity
PJW04_11630	COG0129	dihydroxy-acid dehydratase activity
PJW04_11635	COG0800	Aldolase
PJW04_11700	COG0784	Response regulator, receiver
PJW04_11700	COG2205	protein histidine kinase activity
PJW04_11705	COG2183	response to ionizing radiation
PJW04_11715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PJW04_11715	COG0723	plastoquinol--plastocyanin reductase activity
PJW04_11730	COG3243	poly(R)-hydroxyalkanoic acid synthase
PJW04_11740	COG1183	phosphatidylcholine synthase activity
PJW04_11745	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_11760	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PJW04_11770	COG0668	transmembrane transport
PJW04_11775	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PJW04_11790	COG1914	H( )-stimulated, divalent metal cation uptake system
PJW04_11810	COG2814	Major facilitator Superfamily
PJW04_11825	COG1335	isochorismatase
PJW04_11835	COG4585	Histidine kinase
PJW04_11840	COG2197	response regulator
PJW04_11855	COG0583	DNA-binding transcription factor activity
PJW04_11875	COG0633	Ferredoxin
PJW04_11885	COG0583	DNA-binding transcription factor activity
PJW04_11890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PJW04_11895	COG3002	Belongs to the UPF0753 family
PJW04_11900	COG0667	Aldo Keto reductase
PJW04_11905	COG0667	Aldo Keto reductase
PJW04_11910	COG0583	DNA-binding transcription factor activity
PJW04_11920	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_11925	COG0519	Catalyzes the synthesis of GMP from XMP
PJW04_11960	COG1573	uracil-dna glycosylase
PJW04_11965	COG1573	uracil-dna glycosylase
PJW04_12015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PJW04_12020	COG0798	PFAM Bile acid sodium symporter
PJW04_12090	COG0582	viral genome integration into host DNA
PJW04_12095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PJW04_12095	COG0519	Catalyzes the synthesis of GMP from XMP
PJW04_12105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PJW04_12115	COG0475	glutathione-regulated potassium exporter activity
PJW04_12115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PJW04_12120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PJW04_12130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PJW04_12135	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PJW04_12145	COG0776	regulation of translation
PJW04_12150	COG0539	negative regulation of cytoplasmic translation
PJW04_12155	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PJW04_12170	COG2957	Belongs to the agmatine deiminase family
PJW04_12175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PJW04_12200	COG0395	ABC-type sugar transport system, permease component
PJW04_12235	COG2350	Protein conserved in bacteria
PJW04_12240	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PJW04_12245	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PJW04_12250	COG1187	pseudouridine synthase activity
PJW04_12270	COG0436	Aminotransferase
PJW04_12275	COG4133	protoheme IX ABC transporter activity
PJW04_12295	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PJW04_12300	COG1138	Cytochrome C-type biogenesis protein
PJW04_12320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PJW04_12325	COG1278	Cold shock
PJW04_12330	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PJW04_12335	COG4988	ABC transporter
PJW04_12345	COG1294	oxidase, subunit
PJW04_12375	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PJW04_12380	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PJW04_12390	COG0165	Argininosuccinate lyase
PJW04_12395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PJW04_12405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PJW04_12410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PJW04_12420	COG0137	argininosuccinate synthase activity
PJW04_12425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PJW04_12435	COG0215	cysteine-tRNA ligase activity
PJW04_12440	COG2166	iron-sulfur cluster assembly
PJW04_12460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PJW04_12465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PJW04_12490	COG4302	ethanolamine ammonia-lyase activity
PJW04_12510	COG4677	pectinesterase activity
PJW04_12525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PJW04_12530	COG0402	S-adenosylhomocysteine deaminase activity
PJW04_12540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PJW04_12545	COG1509	lysine 2,3-aminomutase activity
PJW04_12550	COG3300	MHYT domain
PJW04_12550	COG5001	Diguanylate cyclase
PJW04_12565	COG0483	inositol monophosphate 1-phosphatase activity
PJW04_12570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PJW04_12585	COG0488	(ABC) transporter
PJW04_12590	COG0513	Belongs to the DEAD box helicase family
PJW04_12595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PJW04_12600	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PJW04_12610	COG0625	glutathione transferase activity
PJW04_12620	COG4681	YaeQ
PJW04_12625	COG2081	HI0933 family
PJW04_12635	COG0501	Belongs to the peptidase M48B family
PJW04_12640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PJW04_12645	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_12670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PJW04_12675	COG0860	N-Acetylmuramoyl-L-alanine amidase
PJW04_12680	COG0802	atpase or kinase
PJW04_12685	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PJW04_12685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PJW04_12690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PJW04_12695	COG1570	exodeoxyribonuclease VII activity
PJW04_12710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PJW04_12755	COG0835	chemotaxis
PJW04_12760	COG0840	transmembrane signaling receptor activity
PJW04_12765	COG2094	Belongs to the DNA glycosylase MPG family
PJW04_12770	COG1201	RNA secondary structure unwinding
PJW04_12790	COG2969	positive regulation of protein catabolic process
PJW04_12795	COG0625	glutathione transferase activity
PJW04_12800	COG2857	Cytochrome c1
PJW04_12805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PJW04_12810	COG0723	plastoquinol--plastocyanin reductase activity
PJW04_12815	COG0741	lytic transglycosylase activity
PJW04_12830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PJW04_12835	COG1702	phosphate starvation-inducible protein PhoH
PJW04_12845	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PJW04_12855	COG4535	Mg2 and Co2 transporter CorC
PJW04_12870	COG1012	belongs to the aldehyde dehydrogenase family
PJW04_12875	COG1177	transmembrane transport
PJW04_12880	COG1176	ABC-type spermidine putrescine transport system, permease component I
PJW04_12890	COG3842	ATPase activity
PJW04_12910	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PJW04_12925	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PJW04_12930	COG0174	glutamine synthetase
PJW04_12935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PJW04_12945	COG2703	oxygen carrier activity
PJW04_12950	COG0477	Major facilitator Superfamily
PJW04_12960	COG0243	molybdopterin cofactor binding
PJW04_12965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PJW04_12970	COG2223	nitrite transmembrane transporter activity
PJW04_12975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PJW04_12985	COG2733	membrane
PJW04_12990	COG0784	Response regulator, receiver
PJW04_12990	COG2205	protein histidine kinase activity
PJW04_12990	COG5002	protein histidine kinase activity
PJW04_13000	COG0477	Major facilitator Superfamily
PJW04_13005	COG2902	Dehydrogenase
PJW04_13015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PJW04_13020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PJW04_13025	COG1609	Transcriptional regulator
PJW04_13030	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PJW04_13030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PJW04_13035	COG1105	Belongs to the carbohydrate kinase PfkB family
PJW04_13040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PJW04_13040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PJW04_13100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PJW04_13110	COG1862	Preprotein translocase
PJW04_13115	COG0343	queuine tRNA-ribosyltransferase activity
PJW04_13120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PJW04_13155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PJW04_13160	COG3291	Pkd domain containing protein
PJW04_13165	COG0405	Gamma-glutamyltransferase
PJW04_13170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PJW04_13185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PJW04_13190	COG0742	ribosomal rna small subunit methyltransferase
PJW04_13195	COG0326	Molecular chaperone. Has ATPase activity
PJW04_13265	COG0531	amino acid
PJW04_13280	COG0006	proline dipeptidase activity
PJW04_13290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PJW04_13305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PJW04_13310	COG3938	Belongs to the proline racemase family
PJW04_13320	COG0552	protein localization to endoplasmic reticulum
PJW04_13325	COG1194	a g-specific adenine glycosylase
PJW04_13330	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PJW04_13335	COG4191	Histidine kinase
PJW04_13335	COG0784	Response regulator, receiver
PJW04_13350	COG0322	excinuclease ABC activity
PJW04_13365	COG3040	lipid binding
PJW04_13375	COG1960	acyl-CoA dehydrogenase activity
PJW04_13385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PJW04_13405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PJW04_13410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PJW04_13415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PJW04_13440	COG0438	transferase activity, transferring glycosyl groups
PJW04_13450	COG0438	transferase activity, transferring glycosyl groups
PJW04_13455	COG0438	transferase activity, transferring glycosyl groups
PJW04_13505	COG0072	phenylalanine-tRNA ligase activity
PJW04_13505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PJW04_13510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PJW04_13525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PJW04_13530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PJW04_13555	COG1082	Xylose isomerase domain protein TIM barrel
PJW04_13570	COG0366	Alpha amylase catalytic
PJW04_13635	COG3702	type iv secretory pathway
PJW04_13655	COG2948	multi-organism process
PJW04_13675	COG3505	Type IV secretory pathway VirD4
PJW04_13690	COG0556	nucleotide-excision repair
PJW04_13735	COG3275	phosphorelay sensor kinase activity
PJW04_13740	COG1611	Belongs to the LOG family
PJW04_13750	COG2095	MarC family integral membrane protein
PJW04_13760	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PJW04_13795	COG1185	polyribonucleotide nucleotidyltransferase activity
PJW04_13800	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PJW04_13805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PJW04_13810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PJW04_13815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PJW04_13820	COG0195	Participates in both transcription termination and antitermination
PJW04_13825	COG0779	Required for maturation of 30S ribosomal subunits
PJW04_13835	COG1007	ATP synthesis coupled electron transport
PJW04_13860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PJW04_13865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PJW04_13870	COG1034	ATP synthesis coupled electron transport
PJW04_13875	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
PJW04_13880	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
PJW04_13885	COG0649	NAD binding
PJW04_13890	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PJW04_13895	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PJW04_13900	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PJW04_13915	COG0149	triose-phosphate isomerase activity
PJW04_13920	COG4221	oxidoreductase activity
PJW04_13950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PJW04_13955	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PJW04_13960	COG0159	tryptophan synthase activity
PJW04_13970	COG0133	tryptophan synthase activity
PJW04_13980	COG0135	phosphoribosylanthranilate isomerase activity
PJW04_13985	COG0101	tRNA pseudouridine synthase activity
PJW04_14000	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PJW04_14005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PJW04_14010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PJW04_14015	COG2890	protein-(glutamine-N5) methyltransferase activity
PJW04_14025	COG0688	phosphatidylethanolamine metabolic process
PJW04_14035	COG0433	COG0433 Predicted ATPase
PJW04_14040	COG0494	nUDIX hydrolase
PJW04_14055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PJW04_14060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PJW04_14085	COG0717	Belongs to the dCTP deaminase family
PJW04_14090	COG0489	protein tyrosine kinase activity
PJW04_14110	COG3590	peptidase
PJW04_14115	COG3590	peptidase
PJW04_14135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PJW04_14140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PJW04_14145	COG2311	Membrane
PJW04_14150	COG1047	Peptidyl-prolyl cis-trans
PJW04_14155	COG0791	NLP P60 protein
PJW04_14160	COG0791	NLP P60 protein
PJW04_14175	COG1301	dicarboxylic acid transport
PJW04_14180	COG1785	Belongs to the alkaline phosphatase family
PJW04_14185	COG0037	tRNA processing
PJW04_14190	COG1722	exodeoxyribonuclease VII activity
PJW04_14195	COG0142	geranyltranstransferase activity
PJW04_14200	COG4104	PAAR repeat-containing protein
PJW04_14210	COG0312	modulator of DNA gyrase
PJW04_14215	COG3028	Belongs to the UPF0307 family
PJW04_14220	COG0312	modulator of DNA gyrase
PJW04_14230	COG3164	Protein of unknown function
PJW04_14240	COG0424	maF-like protein
PJW04_14245	COG2968	Membrane
PJW04_14255	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PJW04_14270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PJW04_14285	COG0495	leucyl-tRNA aminoacylation
PJW04_14295	COG3118	belongs to the thioredoxin family
PJW04_14325	COG2155	Conserved Protein
PJW04_14370	COG1132	(ABC) transporter
PJW04_14395	COG1538	Outer membrane efflux protein
PJW04_14400	COG0745	RESPONSE REGULATOR receiver
PJW04_14405	COG5000	phosphorelay sensor kinase activity
PJW04_14405	COG5002	protein histidine kinase activity
PJW04_14410	COG0475	glutathione-regulated potassium exporter activity
PJW04_14420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PJW04_14440	COG1187	pseudouridine synthase activity
PJW04_14445	COG5002	protein histidine kinase activity
PJW04_14445	COG5001	Diguanylate cyclase
PJW04_14560	COG0667	Aldo Keto reductase
PJW04_14565	COG2814	Major facilitator Superfamily
PJW04_14570	COG0583	DNA-binding transcription factor activity
PJW04_14580	COG2207	Transcriptional regulator
PJW04_14595	COG1309	transcriptional regulator
PJW04_14605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PJW04_14620	COG0735	belongs to the Fur family
PJW04_14625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PJW04_14650	COG4452	Inner membrane protein CreD
PJW04_14660	COG2205	protein histidine kinase activity
PJW04_14665	COG0745	RESPONSE REGULATOR receiver
PJW04_14670	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PJW04_14680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PJW04_14695	COG2198	Histidine kinase
PJW04_14695	COG0643	Histidine kinase
PJW04_14700	COG0840	transmembrane signaling receptor activity
PJW04_14705	COG0835	chemotaxis
PJW04_14710	COG2199	diguanylate cyclase activity
PJW04_14710	COG2200	EAL domain
PJW04_14710	COG2202	Pas domain
PJW04_14715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PJW04_14720	COG2201	protein-glutamate methylesterase activity
PJW04_14725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PJW04_14730	COG3590	peptidase
PJW04_14740	COG0588	phosphoglycerate mutase activity
PJW04_14745	COG1515	deoxyribonuclease V activity
PJW04_14755	COG1741	Belongs to the pirin family
PJW04_14770	COG1741	Belongs to the pirin family
PJW04_14775	COG1966	Carbon starvation protein
PJW04_14780	COG2879	small protein
PJW04_14815	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PJW04_14820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PJW04_14825	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
PJW04_14830	COG2080	2 iron, 2 sulfur cluster binding
PJW04_14835	COG3321	synthase
PJW04_14835	COG0604	alcohol dehydrogenase
PJW04_14835	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_14840	COG2203	Gaf domain
PJW04_14840	COG5001	Diguanylate cyclase
PJW04_14840	COG4251	negative regulation of phosphorylation
PJW04_14840	COG3706	GGDEF domain
PJW04_14845	COG0629	single-stranded DNA binding
PJW04_14850	COG0142	geranyltranstransferase activity
PJW04_14860	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PJW04_14875	COG0527	aspartate kinase activity
PJW04_14880	COG0384	phenazine biosynthesis protein PhzF
PJW04_14885	COG0384	phenazine biosynthesis protein PhzF
PJW04_14895	COG1764	response to oxidative stress
PJW04_14900	COG0540	Belongs to the ATCase OTCase family
PJW04_14905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PJW04_14910	COG1678	Uncharacterized ACR, COG1678
PJW04_14915	COG0519	Catalyzes the synthesis of GMP from XMP
PJW04_14940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PJW04_14955	COG0739	heme binding
PJW04_14975	COG0693	protein deglycase activity
PJW04_14985	COG1959	2 iron, 2 sulfur cluster binding
PJW04_14990	COG0719	Fe-S assembly protein
PJW04_14995	COG0396	ATPase activity
PJW04_15000	COG0719	Fe-S assembly protein
PJW04_15005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PJW04_15010	COG0456	acetyltransferase
PJW04_15015	COG2146	nitrite reductase [NAD(P)H] activity
PJW04_15020	COG4774	siderophore transport
PJW04_15025	COG3128	pkhd-type hydroxylase
PJW04_15050	COG1477	protein flavinylation
PJW04_15055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PJW04_15070	COG1555	photosystem II stabilization
PJW04_15090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PJW04_15100	COG0628	permease
PJW04_15110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PJW04_15120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PJW04_15140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PJW04_15145	COG0271	Belongs to the BolA IbaG family
PJW04_15155	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PJW04_15165	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PJW04_15170	COG1137	ATPase activity
PJW04_15185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PJW04_15190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PJW04_15195	COG1660	Displays ATPase and GTPase activities
PJW04_15205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PJW04_15210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PJW04_15220	COG2239	Acts as a magnesium transporter
PJW04_15230	COG1294	oxidase, subunit
PJW04_15235	COG1271	oxidase subunit
PJW04_15245	COG1113	amino acid transport
PJW04_15260	COG2197	response regulator
PJW04_15265	COG0531	amino acid
PJW04_15325	COG2814	Major facilitator Superfamily
PJW04_15330	COG0754	glutathionylspermidine amidase activity
PJW04_15355	COG1842	Phage shock protein A
PJW04_15365	COG0259	pyridoxamine-phosphate oxidase activity
PJW04_15370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PJW04_15375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PJW04_15385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PJW04_15390	COG2814	Major facilitator Superfamily
PJW04_15410	COG2205	protein histidine kinase activity
PJW04_15410	COG2198	Histidine kinase
PJW04_15410	COG0784	Response regulator, receiver
PJW04_15415	COG2353	YceI-like domain
PJW04_15435	COG1760	l-serine dehydratase
PJW04_15445	COG0460	homoserine dehydrogenase
PJW04_15445	COG0527	aspartate kinase activity
PJW04_15450	COG0626	cystathionine gamma-synthase activity
PJW04_15455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PJW04_15460	COG0739	heme binding
PJW04_15465	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PJW04_15470	COG1272	protein, Hemolysin III
PJW04_15475	COG2982	Protein involved in outer membrane biogenesis
PJW04_15480	COG0517	IMP dehydrogenase activity
PJW04_15480	COG0516	GMP reductase activity
PJW04_15485	COG0463	Glycosyl transferase, family 2
PJW04_15490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PJW04_15495	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PJW04_15510	COG1309	transcriptional regulator
PJW04_15520	COG1960	acyl-CoA dehydrogenase activity
PJW04_15555	COG0509	glycine decarboxylation via glycine cleavage system
PJW04_15560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PJW04_15575	COG1742	UPF0060 membrane protein
PJW04_15580	COG3956	TIGRFAM MazG family protein
PJW04_15590	COG0494	nUDIX hydrolase
PJW04_15600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PJW04_15605	COG0837	glucose binding
PJW04_15620	COG3858	chitin binding
PJW04_15620	COG1388	LysM domain
PJW04_15625	COG3525	Glycosyl hydrolase, family 20, catalytic domain
PJW04_15635	COG1472	Belongs to the glycosyl hydrolase 3 family
PJW04_15645	COG3537	Alpha-1,2-mannosidase
PJW04_15680	COG3142	Participates in the control of copper homeostasis
PJW04_15685	COG1446	asparaginase
PJW04_15690	COG2304	oxidoreductase activity
PJW04_15695	COG1595	DNA-templated transcription, initiation
PJW04_15720	COG2198	Histidine kinase
PJW04_15720	COG0784	Response regulator, receiver
PJW04_15720	COG0643	Histidine kinase
PJW04_15725	COG0840	transmembrane signaling receptor activity
PJW04_15730	COG0835	chemotaxis
PJW04_15745	COG0189	ligase activity
PJW04_15780	COG1214	PFAM Peptidase M22, glycoprotease
PJW04_15785	COG1199	ATP-dependent helicase activity
PJW04_15795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PJW04_15800	COG1215	transferase activity, transferring glycosyl groups
PJW04_15810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PJW04_15820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PJW04_15825	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
PJW04_15830	COG0535	radical SAM domain protein
PJW04_15835	COG0535	radical SAM domain protein
PJW04_15850	COG0837	glucose binding
PJW04_15860	COG1643	Atp-dependent helicase
PJW04_15865	COG0783	Belongs to the Dps family
PJW04_15870	COG0514	ATP-dependent DNA helicase (RecQ)
PJW04_15890	COG1187	pseudouridine synthase activity
PJW04_15900	COG0840	transmembrane signaling receptor activity
PJW04_15920	COG3920	Histidine kinase
PJW04_15925	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PJW04_15935	COG0602	queuosine metabolic process
PJW04_15945	COG2885	chlorophyll binding
PJW04_15950	COG0823	Involved in the tonB-independent uptake of proteins
PJW04_15960	COG0848	biopolymer transport protein
PJW04_15970	COG0824	Thioesterase
PJW04_15975	COG2255	four-way junction helicase activity
PJW04_15985	COG3158	transport of potassium into the cell
PJW04_15990	COG0632	four-way junction helicase activity
PJW04_15995	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PJW04_16000	COG0217	transcriptional regulatory protein
PJW04_16030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PJW04_16045	COG0477	Major facilitator Superfamily
PJW04_16060	COG0657	acetylesterase activity
PJW04_16060	COG2755	lipolytic protein G-D-S-L family
PJW04_16080	COG0488	(ABC) transporter
PJW04_16110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PJW04_16110	COG4651	solute:proton antiporter activity
PJW04_16135	COG4772	TonB-dependent receptor
PJW04_16145	COG4264	IucA IucC family
PJW04_16150	COG2814	Major facilitator Superfamily
PJW04_16160	COG0019	diaminopimelate decarboxylase activity
PJW04_16190	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PJW04_16200	COG1492	cobalamin metabolic process
PJW04_16210	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PJW04_16230	COG4206	TonB-dependent receptor
PJW04_16235	COG0542	response to heat
PJW04_16240	COG1116	anion transmembrane transporter activity
PJW04_16280	COG4771	TonB-dependent receptor
PJW04_16285	COG1877	trehalose-phosphatase activity
PJW04_16290	COG3387	PFAM Glycoside hydrolase 15-related
PJW04_16305	COG0840	transmembrane signaling receptor activity
PJW04_16310	COG3011	Protein conserved in bacteria
PJW04_16325	COG0564	pseudouridine synthase activity
PJW04_16330	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PJW04_16340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PJW04_16340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PJW04_16355	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PJW04_16360	COG0045	succinate-CoA ligase (ADP-forming) activity
PJW04_16430	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PJW04_16435	COG0237	dephospho-CoA kinase activity
PJW04_16445	COG0745	RESPONSE REGULATOR receiver
PJW04_16455	COG0189	ligase activity
PJW04_16495	COG2022	thiamine diphosphate biosynthetic process
PJW04_16500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PJW04_16505	COG0471	metal ion transport
PJW04_16505	COG3273	potassium ion transport
PJW04_16525	COG1970	mechanosensitive ion channel activity
PJW04_16535	COG1609	Transcriptional regulator
PJW04_16545	COG3250	beta-galactosidase activity
PJW04_16550	COG4948	Mandelate Racemase Muconate Lactonizing
PJW04_16565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PJW04_16580	COG0308	aminopeptidase N
PJW04_16585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PJW04_16600	COG0529	Catalyzes the synthesis of activated sulfate
PJW04_16600	COG2895	sulfate adenylyltransferase (ATP) activity
PJW04_16605	COG0175	sulfate reduction
PJW04_16610	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PJW04_16615	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PJW04_16620	COG0175	sulfate reduction
PJW04_16640	COG2205	protein histidine kinase activity
PJW04_16640	COG2198	Histidine kinase
PJW04_16640	COG0784	Response regulator, receiver
PJW04_16665	COG1648	precorrin-2 dehydrogenase activity
PJW04_16665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PJW04_16680	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
PJW04_16685	COG3588	fructose-bisphosphate aldolase
PJW04_16690	COG0469	pyruvate kinase activity
PJW04_16700	COG0126	phosphoglycerate kinase activity
PJW04_16720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PJW04_16735	COG3047	cAMP biosynthetic process
PJW04_16750	COG0725	ABC transporter, periplasmic molybdate-binding protein
PJW04_16755	COG4149	molybdate abc transporter
PJW04_16760	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PJW04_16795	COG1376	ErfK ybiS ycfS ynhG family protein
PJW04_16800	COG0739	heme binding
PJW04_16805	COG4773	Receptor
PJW04_16810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PJW04_16815	COG1301	dicarboxylic acid transport
PJW04_16825	COG2304	oxidoreductase activity
PJW04_16845	COG0714	Associated with various cellular activities
PJW04_16875	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PJW04_16895	COG1957	nucleoside hydrolase
PJW04_16900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PJW04_16910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PJW04_16920	COG0194	GDP metabolic process
PJW04_16925	COG1561	YicC-like family, N-terminal region
PJW04_16930	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PJW04_16940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PJW04_16945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PJW04_16960	COG0006	proline dipeptidase activity
PJW04_16970	COG0006	proline dipeptidase activity
PJW04_16975	COG3079	Belongs to the UPF0149 family
PJW04_16995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PJW04_17005	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PJW04_17015	COG2912	Transglutaminase-like superfamily
PJW04_17020	COG1773	rubredoxin
PJW04_17025	COG0352	thiamine-phosphate diphosphorylase activity
PJW04_17035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PJW04_17050	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
PJW04_17055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PJW04_17085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PJW04_17090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PJW04_17095	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_17105	COG0671	phosphoesterase, PA-phosphatase related
PJW04_17110	COG3781	membrane
PJW04_17120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PJW04_17125	COG0563	adenylate kinase activity
PJW04_17140	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
PJW04_17150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PJW04_17170	COG3710	Transcriptional regulator
PJW04_17175	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PJW04_17185	COG0840	transmembrane signaling receptor activity
PJW04_17190	COG0405	Gamma-glutamyltransferase
PJW04_17195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PJW04_17215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PJW04_17220	COG0473	3-isopropylmalate dehydrogenase activity
PJW04_17225	COG0066	3-isopropylmalate dehydratase activity
PJW04_17230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PJW04_17250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PJW04_17255	COG1538	Outer membrane efflux protein
PJW04_17260	COG1519	Transferase
PJW04_17265	COG1560	Kdo2-lipid A biosynthetic process
PJW04_17290	COG0281	malic enzyme
PJW04_17290	COG0280	phosphate acetyltransferase
PJW04_17295	COG1301	dicarboxylic acid transport
PJW04_17320	COG0583	DNA-binding transcription factor activity
PJW04_17325	COG0667	Aldo Keto reductase
PJW04_17340	COG2197	response regulator
PJW04_17350	COG0642	Histidine kinase
PJW04_17365	COG2851	Citrate transporter
PJW04_17370	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_17375	COG1609	Transcriptional regulator
PJW04_17380	COG2211	Major facilitator Superfamily
PJW04_17405	COG1162	GTPase activity
PJW04_17410	COG0436	Aminotransferase
PJW04_17425	COG0726	polysaccharide deacetylase
PJW04_17430	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PJW04_17445	COG3964	amidohydrolase
PJW04_17450	COG0402	S-adenosylhomocysteine deaminase activity
PJW04_17470	COG1307	EDD domain protein, DegV family
PJW04_17475	COG0242	peptide deformylase activity
PJW04_17495	COG0457	Tetratricopeptide repeat
PJW04_17500	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
PJW04_17505	COG1215	transferase activity, transferring glycosyl groups
PJW04_17510	COG1215	transferase activity, transferring glycosyl groups
PJW04_17525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PJW04_17570	COG2188	Transcriptional regulator
PJW04_17580	COG1450	Type ii and iii secretion system protein
PJW04_17595	COG3166	PFAM Fimbrial assembly family protein
PJW04_17600	COG3156	type II secretion system protein K
PJW04_17605	COG4795	General secretion pathway protein
PJW04_17610	COG2165	general secretion pathway protein
PJW04_17615	COG4970	Tfp pilus assembly protein FimT
PJW04_17620	COG2165	general secretion pathway protein
PJW04_17625	COG1459	type II secretion system
PJW04_17630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PJW04_17635	COG1404	Belongs to the peptidase S8 family
PJW04_17640	COG5295	Hep Hag repeat protein
PJW04_17645	COG1404	Belongs to the peptidase S8 family
PJW04_17650	COG5295	Hep Hag repeat protein
PJW04_17655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PJW04_17655	COG0047	phosphoribosylformylglycinamidine synthase activity
PJW04_17660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PJW04_17665	COG4974	Belongs to the 'phage' integrase family
PJW04_17680	COG0795	lipopolysaccharide-transporting ATPase activity
PJW04_17690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PJW04_17705	COG0525	valine-tRNA ligase activity
PJW04_17735	COG1183	phosphatidylcholine synthase activity
PJW04_17745	COG0442	prolyl-tRNA aminoacylation
PJW04_17760	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PJW04_17765	COG1127	ABC transporter
PJW04_17770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PJW04_17770	COG3218	ABC-type transport auxiliary lipoprotein component
PJW04_17800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PJW04_17805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PJW04_17810	COG0662	Cupin 2, conserved barrel domain protein
PJW04_17810	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PJW04_17840	COG2086	electron transfer activity
PJW04_17855	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PJW04_17855	COG0546	phosphoglycolate phosphatase activity
PJW04_17860	COG0277	FAD linked oxidase domain protein
PJW04_17870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PJW04_17910	COG0626	cystathionine gamma-synthase activity
PJW04_17940	COG0625	glutathione transferase activity
PJW04_17950	COG0513	Belongs to the DEAD box helicase family
PJW04_17955	COG0720	synthase
PJW04_17965	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PJW04_17970	COG1956	GAF domain-containing protein
PJW04_17985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PJW04_17990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PJW04_18005	COG0339	signal peptide processing
PJW04_18055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PJW04_18060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PJW04_18065	COG1136	(ABC) transporter
PJW04_18070	COG0577	efflux transmembrane transporter activity
PJW04_18075	COG0577	efflux transmembrane transporter activity
PJW04_18090	COG4191	Histidine kinase
PJW04_18095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PJW04_18115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PJW04_18120	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PJW04_18125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PJW04_18130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PJW04_18135	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PJW04_18140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PJW04_18150	COG0356	it plays a direct role in the translocation of protons across the membrane
PJW04_18170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PJW04_18180	COG0508	dehydrogenase complex catalyzes the overall conversion of
PJW04_18215	COG2011	ABC-type metal ion transport system permease component
PJW04_18220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PJW04_18225	COG0697	spore germination
PJW04_18230	COG1666	GTP binding
PJW04_18240	COG0784	Response regulator, receiver
PJW04_18240	COG2198	Histidine kinase
PJW04_18240	COG5002	protein histidine kinase activity
PJW04_18260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PJW04_18265	COG1187	pseudouridine synthase activity
PJW04_18270	COG2813	Specifically methylates the guanine in position
PJW04_18290	COG2205	protein histidine kinase activity
PJW04_18290	COG2202	Pas domain
PJW04_18310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PJW04_18315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PJW04_18370	COG0842	Transport permease protein
PJW04_18375	COG1131	(ABC) transporter
PJW04_18380	COG0025	NhaP-type Na H and K H
PJW04_18385	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
PJW04_18390	COG1573	uracil-dna glycosylase
PJW04_18400	COG3384	dioxygenase
PJW04_18405	COG0583	DNA-binding transcription factor activity
PJW04_18415	COG0667	Aldo Keto reductase
PJW04_18425	COG3590	peptidase
PJW04_18440	COG0531	amino acid
PJW04_18455	COG2972	Histidine kinase
PJW04_18470	COG3685	Protein conserved in bacteria
PJW04_18475	COG3546	catalase activity
PJW04_18505	COG2204	response regulator
PJW04_18515	COG1271	oxidase subunit
PJW04_18520	COG1294	oxidase, subunit
PJW04_18535	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_18540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PJW04_18560	COG1132	(ABC) transporter
PJW04_18575	COG1063	alcohol dehydrogenase
PJW04_18655	COG0251	oxidation-reduction process
PJW04_18675	COG0583	DNA-binding transcription factor activity
PJW04_18680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PJW04_18710	COG0659	secondary active sulfate transmembrane transporter activity
PJW04_18715	COG0038	chloride channel
PJW04_18725	COG0024	Methionine aminopeptidase
PJW04_18740	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_18780	COG4695	Portal protein
PJW04_19020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PJW04_19025	COG1490	D-aminoacyl-tRNA deacylase activity
PJW04_19030	COG1560	Kdo2-lipid A biosynthetic process
PJW04_19075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PJW04_19075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PJW04_19080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PJW04_19085	COG0242	peptide deformylase activity
PJW04_19090	COG1652	LysM domain
PJW04_19095	COG0758	DNA mediated transformation
PJW04_19115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PJW04_19115	COG1754	DNA topoisomerase type I activity
PJW04_19120	COG0009	L-threonylcarbamoyladenylate synthase
PJW04_19135	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_19145	COG0616	signal peptide processing
PJW04_19150	COG0534	Mate efflux family protein
PJW04_19170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PJW04_19175	COG0625	glutathione transferase activity
PJW04_19190	COG1252	NADH dehydrogenase
PJW04_19195	COG2860	membrane
PJW04_19200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PJW04_19205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PJW04_19210	COG2201	protein-glutamate methylesterase activity
PJW04_19215	COG2177	Part of the ABC transporter FtsEX involved in
PJW04_19220	COG2884	Cell division ATP-binding protein ftsE
PJW04_19230	COG3118	belongs to the thioredoxin family
PJW04_19235	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PJW04_19245	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PJW04_19250	COG0583	DNA-binding transcription factor activity
PJW04_19270	COG1652	LysM domain
PJW04_19275	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PJW04_19275	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PJW04_19280	COG1473	amidohydrolase
PJW04_19285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PJW04_19290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PJW04_19300	COG5383	Protein conserved in bacteria
PJW04_19340	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
PJW04_19345	COG3023	N-Acetylmuramoyl-L-alanine amidase
PJW04_19355	COG4948	Mandelate Racemase Muconate Lactonizing
PJW04_19365	COG0531	amino acid
PJW04_19385	COG2133	pyrroloquinoline quinone binding
PJW04_19395	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PJW04_19400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PJW04_19410	COG1610	YqeY-like protein
PJW04_19420	COG1295	ribonuclease BN
PJW04_19425	COG0358	DNA primase activity
PJW04_19440	COG0109	protoheme IX farnesyltransferase activity
PJW04_19470	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PJW04_19485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PJW04_19525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PJW04_19530	COG0739	heme binding
PJW04_19535	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PJW04_19545	COG2211	Major facilitator Superfamily
PJW04_19550	COG0708	Exodeoxyribonuclease III
PJW04_19555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PJW04_19565	COG1192	Involved in chromosome partitioning
PJW04_19570	COG1475	DNA binding
PJW04_19585	COG0463	Glycosyl transferase, family 2
PJW04_19605	COG0756	dUTP diphosphatase activity
PJW04_19610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PJW04_19615	COG2003	Belongs to the UPF0758 family
PJW04_19620	COG0018	arginyl-trna synthetase
PJW04_19635	COG4221	oxidoreductase activity
PJW04_19640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PJW04_19640	COG2755	lipolytic protein G-D-S-L family
PJW04_19650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PJW04_19650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PJW04_19660	COG1166	arginine decarboxylase activity
PJW04_19665	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PJW04_19685	COG3291	Pkd domain containing protein
PJW04_19685	COG3525	Glycosyl hydrolase, family 20, catalytic domain
PJW04_19700	COG0606	chelatase, subunit chli
PJW04_19715	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PJW04_19740	COG1690	Belongs to the RtcB family
PJW04_19780	COG1090	epimerase
PJW04_19790	COG0642	Histidine kinase
PJW04_19810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PJW04_19835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PJW04_19840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PJW04_19855	COG0753	catalase activity
PJW04_19870	COG2197	response regulator
PJW04_19875	COG4585	Histidine kinase
PJW04_19880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PJW04_19885	COG1136	(ABC) transporter
PJW04_19910	COG0697	spore germination
PJW04_19925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PJW04_19930	COG0180	Tryptophanyl-tRNA synthetase
PJW04_19935	COG3237	CsbD-like
PJW04_19975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PJW04_19990	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PJW04_19995	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PJW04_19995	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PJW04_20035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PJW04_20055	COG1199	ATP-dependent helicase activity
PJW04_20070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PJW04_20120	COG0625	glutathione transferase activity
PJW04_20155	COG4555	ABC transporter
PJW04_20165	COG1476	TRANSCRIPTIONal
PJW04_20190	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PJW04_20195	COG1131	(ABC) transporter
PJW04_20200	COG0842	Transport permease protein
PJW04_20205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PJW04_20230	COG0716	FMN binding
PJW04_20235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PJW04_20240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PJW04_20250	COG0045	succinate-CoA ligase (ADP-forming) activity
PJW04_20250	COG1042	CoA-binding domain protein
PJW04_20250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PJW04_20255	COG2239	Acts as a magnesium transporter
PJW04_20270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PJW04_20275	COG3387	PFAM Glycoside hydrolase 15-related
PJW04_20290	COG3100	YcgL domain-containing protein
PJW04_20295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PJW04_20305	COG0463	Glycosyl transferase, family 2
PJW04_20325	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_20380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PJW04_20415	COG0408	coproporphyrinogen oxidase activity
PJW04_20455	COG0515	serine threonine protein kinase
PJW04_20460	COG0631	protein serine/threonine phosphatase activity
PJW04_20485	COG0667	Aldo Keto reductase
PJW04_20490	COG0583	DNA-binding transcription factor activity
PJW04_20650	COG0210	DNA helicase
PJW04_20665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PJW04_20670	COG0583	DNA-binding transcription factor activity
PJW04_20675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PJW04_20685	COG2159	amidohydrolase
PJW04_20710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PJW04_20730	COG0357	Ribosomal RNA small subunit methyltransferase G
PJW04_20735	COG3540	Alkaline phosphatase
PJW04_20745	COG2091	lysine biosynthetic process via aminoadipic acid
PJW04_20760	COG0708	Exodeoxyribonuclease III
PJW04_20765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PJW04_20770	COG3162	membrane
PJW04_20780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PJW04_20810	COG3507	Belongs to the glycosyl hydrolase 43 family
PJW04_20830	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_20835	COG0179	Fumarylacetoacetate (FAA) hydrolase
PJW04_20840	COG4948	Mandelate Racemase Muconate Lactonizing
PJW04_20845	COG3254	rhamnose metabolic process
PJW04_20850	COG0738	Major facilitator superfamily
PJW04_20855	COG1414	Transcriptional regulator
PJW04_20860	COG1971	Probably functions as a manganese efflux pump
PJW04_20865	COG2205	protein histidine kinase activity
PJW04_20875	COG3459	Glycosyltransferase 36 associated
PJW04_20880	COG2211	Major facilitator Superfamily
PJW04_20885	COG3265	gluconokinase activity
PJW04_20890	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PJW04_20930	COG3209	COG3209 Rhs family protein
PJW04_20950	COG2911	Protein conserved in bacteria
PJW04_20955	COG0729	surface antigen
PJW04_20960	COG4771	TonB-dependent receptor
PJW04_20965	COG0457	Tetratricopeptide repeat
PJW04_20975	COG0752	glycyl-tRNA synthetase alpha subunit
PJW04_20980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PJW04_20990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PJW04_20990	COG0519	Catalyzes the synthesis of GMP from XMP
PJW04_21000	COG0805	protein transport
PJW04_21005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PJW04_21010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PJW04_21020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PJW04_21040	COG2974	May be involved in recombination
PJW04_21045	COG0037	tRNA processing
PJW04_21050	COG2115	Belongs to the xylose isomerase family
PJW04_21065	COG3661	Belongs to the glycosyl hydrolase 67 family
PJW04_21075	COG4948	Mandelate Racemase Muconate Lactonizing
PJW04_21085	COG1472	Belongs to the glycosyl hydrolase 3 family
PJW04_21090	COG0246	Mannitol dehydrogenase
PJW04_21140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PJW04_21165	COG3386	PFAM SMP-30 Gluconolaconase
PJW04_21175	COG3250	beta-galactosidase activity
PJW04_21180	COG1904	glucuronate isomerase
PJW04_21185	COG3693	PFAM glycoside hydrolase, family 10
PJW04_21200	COG3693	PFAM glycoside hydrolase, family 10
PJW04_21215	COG2211	Major facilitator Superfamily
PJW04_21260	COG2937	Belongs to the GPAT DAPAT family
PJW04_21290	COG0284	orotidine-5'-phosphate decarboxylase activity
PJW04_21295	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
PJW04_21300	COG3132	Protein of unknown function, DUF480
PJW04_21315	COG0210	DNA helicase
PJW04_21320	COG1435	thymidine kinase activity
PJW04_21330	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PJW04_21340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PJW04_21370	COG3135	benzoate transporter
PJW04_21390	COG0676	glucose-6-phosphate 1-epimerase activity
PJW04_21400	COG3012	SEC-C Motif Domain Protein
PJW04_21405	COG0730	response to heat
PJW04_21425	COG0302	gtp cyclohydrolase
PJW04_21440	COG1566	PFAM secretion protein HlyD family protein
PJW04_21450	COG1289	transmembrane transporter activity
PJW04_21455	COG0477	Major facilitator Superfamily
PJW04_21465	COG0583	DNA-binding transcription factor activity
PJW04_21470	COG4221	oxidoreductase activity
PJW04_21480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PJW04_21535	COG0564	pseudouridine synthase activity
PJW04_21560	COG2801	Transposase and inactivated derivatives
PJW04_21580	COG1309	transcriptional regulator
PJW04_21590	COG1028	Short-chain dehydrogenase reductase Sdr
PJW04_21640	COG1074	ATP-dependent DNA helicase activity
PJW04_21645	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PJW04_21680	COG1127	ABC transporter
PJW04_21685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PJW04_21690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PJW04_21705	COG2853	Lipoprotein
PJW04_21715	COG0386	Belongs to the glutathione peroxidase family
PJW04_21725	COG1322	Protein conserved in bacteria
PJW04_21730	COG0604	alcohol dehydrogenase
PJW04_21755	COG0531	amino acid
PJW04_21760	COG3537	Alpha-1,2-mannosidase
PJW04_21775	COG2199	diguanylate cyclase activity
PJW04_21775	COG2203	Gaf domain
PJW04_21780	COG3835	regulator
PJW04_21785	COG1929	Belongs to the glycerate kinase type-1 family
PJW04_21790	COG2271	Major facilitator Superfamily
PJW04_21805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PJW04_21810	COG0861	Integral membrane protein TerC family
PJW04_21820	COG0584	glycerophosphoryl diester phosphodiesterase
PJW04_21835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PJW04_21840	COG0726	polysaccharide deacetylase
PJW04_21850	COG0706	membrane insertase activity
PJW04_21855	COG0594	ribonuclease P activity
PJW04_21930	COG4962	Type ii secretion system protein e
PJW04_21945	COG3451	type IV secretory pathway VirB4
PJW04_21960	COG3846	protein secretion by the type IV secretion system
PJW04_21995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PJW04_22225	COG1475	DNA binding
PJW04_22245	COG2885	chlorophyll binding
PJW04_22330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PJW04_22410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PJW04_22510	COG1192	Involved in chromosome partitioning