locus-tag	class	description
FLG15_00045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FLG15_00090	COG3237	CsbD-like
FLG15_00135	COG3210	domain, Protein
FLG15_00140	COG2831	hemolysin activation secretion protein
FLG15_00150	COG0366	Alpha amylase catalytic
FLG15_00155	COG0366	Alpha amylase catalytic
FLG15_00160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FLG15_00180	COG2755	lipolytic protein G-D-S-L family
FLG15_00180	COG0657	acetylesterase activity
FLG15_00190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FLG15_00205	COG3507	Belongs to the glycosyl hydrolase 43 family
FLG15_00210	COG1609	Transcriptional regulator
FLG15_00220	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FLG15_00225	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_00240	COG2755	lipolytic protein G-D-S-L family
FLG15_00250	COG3186	Phenylalanine-4-hydroxylase
FLG15_00255	COG1522	sequence-specific DNA binding
FLG15_00265	COG1752	Esterase of the alpha-beta hydrolase superfamily
FLG15_00275	COG1119	ATPase activity
FLG15_00290	COG1125	glycine betaine transport
FLG15_00305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FLG15_00310	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FLG15_00340	COG0489	protein tyrosine kinase activity
FLG15_00345	COG2062	phosphohistidine phosphatase, SixA
FLG15_00355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FLG15_00400	COG1968	undecaprenyl-diphosphatase activity
FLG15_00410	COG0174	glutamine synthetase
FLG15_00415	COG0347	Belongs to the P(II) protein family
FLG15_00420	COG0004	ammonium transporteR
FLG15_00425	COG3852	Histidine kinase
FLG15_00430	COG2204	response regulator
FLG15_00435	COG2032	superoxide dismutase activity
FLG15_00440	COG2032	superoxide dismutase activity
FLG15_00455	COG0183	Belongs to the thiolase family
FLG15_00490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FLG15_00495	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FLG15_00500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FLG15_00510	COG0028	Belongs to the TPP enzyme family
FLG15_00515	COG2205	protein histidine kinase activity
FLG15_00540	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FLG15_00555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FLG15_00565	COG0596	Alpha beta hydrolase
FLG15_00575	COG0318	PFAM AMP-dependent synthetase and ligase
FLG15_00580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FLG15_00600	COG1181	Belongs to the D-alanine--D-alanine ligase family
FLG15_00615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FLG15_00625	COG0564	pseudouridine synthase activity
FLG15_00655	COG1446	asparaginase
FLG15_00660	COG0339	signal peptide processing
FLG15_00695	COG0475	glutathione-regulated potassium exporter activity
FLG15_00705	COG0583	DNA-binding transcription factor activity
FLG15_00710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FLG15_00715	COG2224	Isocitrate lyase
FLG15_00720	COG3706	GGDEF domain
FLG15_00750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FLG15_00755	COG1960	acyl-CoA dehydrogenase activity
FLG15_00820	COG0697	spore germination
FLG15_00830	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FLG15_00835	COG1846	Transcriptional regulator
FLG15_00840	COG1764	response to oxidative stress
FLG15_00860	COG2130	NADP-dependent
FLG15_00875	COG1187	pseudouridine synthase activity
FLG15_00885	COG1643	Atp-dependent helicase
FLG15_00895	COG4807	Protein conserved in bacteria
FLG15_00900	COG2351	hydroxyisourate hydrolase activity
FLG15_00905	COG2072	flavoprotein involved in K transport
FLG15_00925	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FLG15_00935	COG0583	DNA-binding transcription factor activity
FLG15_00975	COG2252	PERMEase
FLG15_00995	COG0084	hydrolase, TatD family'
FLG15_01010	COG0583	DNA-binding transcription factor activity
FLG15_01015	COG2814	Major facilitator Superfamily
FLG15_01030	COG2267	carboxylic ester hydrolase activity
FLG15_01035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FLG15_01040	COG1902	pentaerythritol trinitrate reductase activity
FLG15_01060	COG0745	RESPONSE REGULATOR receiver
FLG15_01065	COG2205	protein histidine kinase activity
FLG15_01070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FLG15_01095	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FLG15_01100	COG0583	DNA-binding transcription factor activity
FLG15_01115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FLG15_01135	COG0702	epimerase
FLG15_01140	COG1733	regulation of RNA biosynthetic process
FLG15_01240	COG0129	dihydroxy-acid dehydratase activity
FLG15_01255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FLG15_01310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FLG15_01315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FLG15_01340	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FLG15_01345	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FLG15_01355	COG3485	protocatechuate 3,4-dioxygenase
FLG15_01360	COG3485	protocatechuate 3,4-dioxygenase
FLG15_01375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FLG15_01380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FLG15_01390	COG1414	Transcriptional regulator
FLG15_01410	COG0445	tRNA wobble uridine modification
FLG15_01455	COG2267	carboxylic ester hydrolase activity
FLG15_01465	COG0156	8-amino-7-oxononanoate synthase activity
FLG15_01470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FLG15_01475	COG1040	competence protein
FLG15_01485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FLG15_01580	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FLG15_01650	COG3264	Mechanosensitive ion channel
FLG15_01650	COG1511	domain protein
FLG15_01655	COG1368	sulfuric ester hydrolase activity
FLG15_01665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FLG15_01675	COG2354	Protein conserved in bacteria
FLG15_01680	COG3706	GGDEF domain
FLG15_01680	COG0745	RESPONSE REGULATOR receiver
FLG15_01685	COG0297	glycogen (starch) synthase activity
FLG15_01690	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FLG15_01695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FLG15_01755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FLG15_01760	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_01770	COG0513	Belongs to the DEAD box helicase family
FLG15_01790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FLG15_01805	COG3483	tryptophan 2,3-dioxygenase activity
FLG15_01810	COG3104	oligopeptide transport
FLG15_01830	COG2852	Protein conserved in bacteria
FLG15_01835	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FLG15_01855	COG1320	monovalent cation:proton antiporter activity
FLG15_01860	COG2212	antiporter activity
FLG15_01870	COG0651	ATP synthesis coupled electron transport
FLG15_01875	COG1006	Multisubunit Na H antiporter MnhC subunit
FLG15_01880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FLG15_01880	COG2111	Na H antiporter
FLG15_01920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FLG15_01925	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FLG15_01935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FLG15_01945	COG1597	lipid kinase activity
FLG15_01980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FLG15_01985	COG0134	indole-3-glycerol-phosphate synthase activity
FLG15_01995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FLG15_02000	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FLG15_02010	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FLG15_02015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FLG15_02020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FLG15_02035	COG1051	belongs to the nudix hydrolase family
FLG15_02075	COG0316	Belongs to the HesB IscA family
FLG15_02085	COG2816	NAD+ diphosphatase activity
FLG15_02090	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FLG15_02115	COG2814	Major facilitator Superfamily
FLG15_02120	COG0583	DNA-binding transcription factor activity
FLG15_02125	COG2814	Major facilitator Superfamily
FLG15_02130	COG1289	transmembrane transporter activity
FLG15_02140	COG0151	Belongs to the GarS family
FLG15_02150	COG0138	bifunctional purine biosynthesis protein purh
FLG15_02155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FLG15_02165	COG0671	phosphoesterase, PA-phosphatase related
FLG15_02165	COG2453	phosphatase
FLG15_02190	COG4589	Belongs to the CDS family
FLG15_02195	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FLG15_02220	COG2264	protein methyltransferase activity
FLG15_02245	COG0439	Biotin carboxylase
FLG15_02255	COG0511	ligase activity, forming carbon-carbon bonds
FLG15_02260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FLG15_02270	COG1324	tolerance protein
FLG15_02280	COG2356	endonuclease I
FLG15_02285	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FLG15_02290	COG0459	protein refolding
FLG15_02305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FLG15_02320	COG3386	PFAM SMP-30 Gluconolaconase
FLG15_02330	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FLG15_02335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FLG15_02360	COG0778	Nitroreductase
FLG15_02365	COG2353	YceI-like domain
FLG15_02400	COG3052	prosthetic group binding
FLG15_02420	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FLG15_02425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FLG15_02435	COG1802	Transcriptional regulator
FLG15_02570	COG4221	oxidoreductase activity
FLG15_02600	COG4221	oxidoreductase activity
FLG15_02610	COG0435	Glutathione S-transferase
FLG15_02665	COG3706	GGDEF domain
FLG15_02670	COG1959	2 iron, 2 sulfur cluster binding
FLG15_02695	COG0697	spore germination
FLG15_02700	COG4305	rare lipoprotein A
FLG15_02710	COG5297	Belongs to the glycosyl hydrolase family 6
FLG15_02720	COG1113	amino acid transport
FLG15_02730	COG0598	Magnesium transport protein CorA
FLG15_02745	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FLG15_02790	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FLG15_02790	COG5297	Belongs to the glycosyl hydrolase family 6
FLG15_02795	COG0659	secondary active sulfate transmembrane transporter activity
FLG15_02800	COG3706	GGDEF domain
FLG15_02815	COG2943	transferase activity, transferring hexosyl groups
FLG15_02825	COG3275	phosphorelay sensor kinase activity
FLG15_02835	COG0181	hydroxymethylbilane synthase activity
FLG15_02875	COG1505	serine-type exopeptidase activity
FLG15_02895	COG2832	Protein of unknown function (DUF454)
FLG15_02905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FLG15_02915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FLG15_02925	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FLG15_02955	COG2226	methyltransferase
FLG15_02960	COG5001	Diguanylate cyclase
FLG15_02960	COG3300	MHYT domain
FLG15_02965	COG0308	aminopeptidase N
FLG15_03015	COG3284	Transcriptional regulator
FLG15_03035	COG1077	Cell shape determining protein MreB Mrl
FLG15_03040	COG1792	Involved in formation and maintenance of cell shape
FLG15_03055	COG0772	Belongs to the SEDS family
FLG15_03065	COG2951	lytic endotransglycosylase activity
FLG15_03070	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FLG15_03075	COG1686	Belongs to the peptidase S11 family
FLG15_03090	COG2921	Belongs to the UPF0250 family
FLG15_03095	COG0321	lipoyl(octanoyl) transferase activity
FLG15_03100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FLG15_03125	COG1051	belongs to the nudix hydrolase family
FLG15_03125	COG1056	cytidyltransferase-related domain
FLG15_03160	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FLG15_03165	COG0673	inositol 2-dehydrogenase activity
FLG15_03170	COG2823	Periplasmic or secreted lipoprotein
FLG15_03175	COG4251	negative regulation of phosphorylation
FLG15_03180	COG0784	Response regulator, receiver
FLG15_03185	COG4191	Histidine kinase
FLG15_03190	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FLG15_03250	COG1459	type II secretion system
FLG15_03305	COG1609	Transcriptional regulator
FLG15_03310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FLG15_03315	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FLG15_03325	COG0617	tRNA 3'-terminal CCA addition
FLG15_03330	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FLG15_03335	COG1012	belongs to the aldehyde dehydrogenase family
FLG15_03340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FLG15_03350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FLG15_03380	COG2205	protein histidine kinase activity
FLG15_03385	COG0745	RESPONSE REGULATOR receiver
FLG15_03410	COG3791	Glutathione-dependent formaldehyde-activating
FLG15_03415	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FLG15_03425	COG0488	(ABC) transporter
FLG15_03435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FLG15_03440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FLG15_03450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FLG15_03450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FLG15_03470	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FLG15_03475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FLG15_03480	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FLG15_03500	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FLG15_03505	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FLG15_03515	COG2205	protein histidine kinase activity
FLG15_03520	COG0745	RESPONSE REGULATOR receiver
FLG15_03525	COG0277	FAD linked oxidase domain protein
FLG15_03530	COG1988	membrane-bound metal-dependent
FLG15_03535	COG0792	nuclease activity
FLG15_03565	COG2001	Belongs to the MraZ family
FLG15_03570	COG0275	rRNA processing
FLG15_03575	COG3116	cell division
FLG15_03585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FLG15_03590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FLG15_03595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FLG15_03605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FLG15_03610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FLG15_03615	COG1181	Belongs to the D-alanine--D-alanine ligase family
FLG15_03620	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FLG15_03635	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FLG15_03645	COG0739	heme binding
FLG15_03650	COG0653	protein targeting
FLG15_03655	COG0494	nUDIX hydrolase
FLG15_03665	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FLG15_03685	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_03685	COG3321	synthase
FLG15_03685	COG0604	alcohol dehydrogenase
FLG15_03745	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FLG15_03750	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FLG15_03760	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FLG15_03800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FLG15_03810	COG4106	trans-aconitate 2-methyltransferase activity
FLG15_03815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FLG15_03825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FLG15_03830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FLG15_03835	COG0667	Aldo Keto reductase
FLG15_03845	COG4771	TonB-dependent receptor
FLG15_03865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FLG15_03870	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FLG15_03880	COG2175	clavaminate synthase activity
FLG15_03890	COG4181	ATPase activity
FLG15_03905	COG0642	Histidine kinase
FLG15_03915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FLG15_03925	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FLG15_03935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FLG15_03940	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FLG15_03955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FLG15_03960	COG2967	ApaG domain
FLG15_03965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FLG15_03970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FLG15_03975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FLG15_03980	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FLG15_03985	COG0123	including yeast histone deacetylase and acetoin utilization protein
FLG15_03990	COG2096	Adenosyltransferase
FLG15_04005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FLG15_04010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FLG15_04040	COG3384	dioxygenase
FLG15_04045	COG0583	DNA-binding transcription factor activity
FLG15_04060	COG1024	Enoyl-CoA hydratase
FLG15_04080	COG3386	PFAM SMP-30 Gluconolaconase
FLG15_04090	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FLG15_04110	COG0697	spore germination
FLG15_04120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FLG15_04135	COG0745	RESPONSE REGULATOR receiver
FLG15_04135	COG3706	GGDEF domain
FLG15_04145	COG2197	response regulator
FLG15_04155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FLG15_04170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FLG15_04175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FLG15_04185	COG0583	DNA-binding transcription factor activity
FLG15_04190	COG3634	alkyl hydroperoxide reductase activity
FLG15_04200	COG2890	protein-(glutamine-N5) methyltransferase activity
FLG15_04220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FLG15_04220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FLG15_04280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FLG15_04285	COG1404	Belongs to the peptidase S8 family
FLG15_04290	COG1404	Belongs to the peptidase S8 family
FLG15_04295	COG1404	Belongs to the peptidase S8 family
FLG15_04300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FLG15_04330	COG1295	ribonuclease BN
FLG15_04335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FLG15_04340	COG1254	Belongs to the acylphosphatase family
FLG15_04355	COG0521	Mo-molybdopterin cofactor biosynthetic process
FLG15_04365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FLG15_04370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FLG15_04380	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FLG15_04385	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FLG15_04395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FLG15_04400	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FLG15_04405	COG0193	aminoacyl-tRNA hydrolase activity
FLG15_04410	COG0012	GTP binding
FLG15_04430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FLG15_04440	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FLG15_04445	COG0250	Participates in transcription elongation, termination and antitermination
FLG15_04450	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FLG15_04455	COG0081	regulation of translation
FLG15_04460	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FLG15_04470	COG0085	RNA polymerase activity
FLG15_04475	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FLG15_04480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FLG15_04485	COG0049	tRNA binding
FLG15_04490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FLG15_04495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FLG15_04505	COG0051	transcription antitermination factor activity, RNA binding
FLG15_04515	COG0088	Forms part of the polypeptide exit tunnel
FLG15_04520	COG0089	rRNA binding
FLG15_04525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FLG15_04530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FLG15_04535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FLG15_04540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FLG15_04550	COG0255	Belongs to the universal ribosomal protein uL29 family
FLG15_04555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FLG15_04560	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FLG15_04565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FLG15_04570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FLG15_04575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FLG15_04580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FLG15_04585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FLG15_04590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FLG15_04595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FLG15_04600	COG1841	ribosomal large subunit assembly
FLG15_04605	COG0200	Binds to the 23S rRNA
FLG15_04610	COG0201	protein transport
FLG15_04615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FLG15_04620	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FLG15_04625	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FLG15_04630	COG0202	RNA polymerase activity
FLG15_04635	COG0203	ribosomal protein L17
FLG15_04640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FLG15_04660	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FLG15_04685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FLG15_04690	COG0039	L-malate dehydrogenase activity
FLG15_04695	COG0625	glutathione transferase activity
FLG15_04715	COG1902	pentaerythritol trinitrate reductase activity
FLG15_04715	COG0446	pyridine nucleotide-disulphide oxidoreductase
FLG15_04720	COG0604	alcohol dehydrogenase
FLG15_04730	COG2885	chlorophyll binding
FLG15_04750	COG0156	8-amino-7-oxononanoate synthase activity
FLG15_04755	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FLG15_04760	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FLG15_04765	COG4208	sulfate ABC transporter
FLG15_04770	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FLG15_04780	COG1063	alcohol dehydrogenase
FLG15_04800	COG0406	alpha-ribazole phosphatase activity
FLG15_04815	COG0285	dihydrofolate synthase activity
FLG15_04835	COG2833	Protein of unknown function (DUF455)
FLG15_04845	COG3291	Pkd domain containing protein
FLG15_04855	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FLG15_04860	COG0671	phosphoesterase, PA-phosphatase related
FLG15_04865	COG0438	transferase activity, transferring glycosyl groups
FLG15_04875	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FLG15_04890	COG4783	chaperone-mediated protein folding
FLG15_04905	COG0473	3-isopropylmalate dehydrogenase activity
FLG15_04945	COG0544	peptidyl-prolyl cis-trans isomerase activity
FLG15_04950	COG0740	serine-type endopeptidase activity
FLG15_04955	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FLG15_04985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FLG15_04995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FLG15_05005	COG0328	RNA-DNA hybrid ribonuclease activity
FLG15_05010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FLG15_05015	COG0631	protein serine/threonine phosphatase activity
FLG15_05030	COG0859	PFAM glycosyl transferase family 9
FLG15_05035	COG3642	lipopolysaccharide core region biosynthetic process
FLG15_05040	COG1234	tRNA 3'-trailer cleavage
FLG15_05045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FLG15_05055	COG0315	cyclic pyranopterin monophosphate synthase activity
FLG15_05060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FLG15_05065	COG0314	molybdopterin synthase activity
FLG15_05210	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FLG15_05215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FLG15_05220	COG0537	adenosine 5'-monophosphoramidase activity
FLG15_05240	COG0714	Associated with various cellular activities
FLG15_05255	COG0424	maF-like protein
FLG15_05260	COG1399	metal-binding, possibly nucleic acid-binding protein
FLG15_05265	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FLG15_05270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FLG15_05285	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_05290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FLG15_05300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FLG15_05305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FLG15_05335	COG3829	transcription factor binding
FLG15_05360	COG2828	Protein conserved in bacteria
FLG15_05380	COG2373	Large extracellular alpha-helical protein
FLG15_05405	COG4953	penicillin-binding protein 1C
FLG15_05415	COG0678	peroxiredoxin activity
FLG15_05435	COG0330	HflC and HflK could
FLG15_05440	COG0330	HflC and HflK could
FLG15_05455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FLG15_05460	COG0308	aminopeptidase N
FLG15_05480	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_05485	COG1309	transcriptional regulator
FLG15_05515	COG0732	type I restriction modification DNA specificity domain
FLG15_05545	COG0406	alpha-ribazole phosphatase activity
FLG15_05545	COG0328	RNA-DNA hybrid ribonuclease activity
FLG15_05550	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FLG15_05560	COG3387	PFAM Glycoside hydrolase 15-related
FLG15_05565	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_05575	COG3537	Alpha-1,2-mannosidase
FLG15_05595	COG0492	ferredoxin-NADP+ reductase activity
FLG15_05625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FLG15_05630	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FLG15_05635	COG2080	2 iron, 2 sulfur cluster binding
FLG15_05670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FLG15_05685	COG0587	DNA-directed DNA polymerase activity
FLG15_05705	COG1297	OPT oligopeptide transporter protein
FLG15_05720	COG1506	peptidase
FLG15_05720	COG0823	Involved in the tonB-independent uptake of proteins
FLG15_05735	COG1917	Cupin 2, conserved barrel domain protein
FLG15_05735	COG2207	Transcriptional regulator
FLG15_05765	COG0753	catalase activity
FLG15_05770	COG0656	L-ascorbic acid biosynthetic process
FLG15_05780	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FLG15_05780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FLG15_05805	COG2814	Major facilitator Superfamily
FLG15_05870	COG2194	sulfuric ester hydrolase activity
FLG15_05885	COG0745	RESPONSE REGULATOR receiver
FLG15_05890	COG0642	Histidine kinase
FLG15_05900	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FLG15_05905	COG2894	cell division
FLG15_05910	COG0850	regulation of cytokinetic process
FLG15_05925	COG4585	Histidine kinase
FLG15_05930	COG2197	response regulator
FLG15_05945	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FLG15_05970	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FLG15_05980	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FLG15_05995	COG1595	DNA-templated transcription, initiation
FLG15_06005	COG1946	Acyl-CoA thioesterase
FLG15_06020	COG0824	Thioesterase
FLG15_06025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FLG15_06030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FLG15_06035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FLG15_06040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FLG15_06045	COG0268	Binds directly to 16S ribosomal RNA
FLG15_06050	COG0728	peptidoglycan biosynthetic process
FLG15_06055	COG0196	riboflavin kinase activity
FLG15_06060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FLG15_06065	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FLG15_06070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FLG15_06085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FLG15_06090	COG1845	cytochrome c oxidase, subunit III
FLG15_06095	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FLG15_06110	COG3152	Membrane
FLG15_06125	COG2207	Transcriptional regulator
FLG15_06130	COG0326	Molecular chaperone. Has ATPase activity
FLG15_06140	COG1366	Belongs to the anti-sigma-factor antagonist family
FLG15_06145	COG1366	Belongs to the anti-sigma-factor antagonist family
FLG15_06150	COG2172	sigma factor antagonist activity
FLG15_06160	COG2205	protein histidine kinase activity
FLG15_06175	COG4771	TonB-dependent receptor
FLG15_06185	COG5507	3-demethylubiquinone-9 3-methyltransferase
FLG15_06190	COG2205	protein histidine kinase activity
FLG15_06200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FLG15_06205	COG2205	protein histidine kinase activity
FLG15_06205	COG4999	Histidine kinase
FLG15_06205	COG3850	Histidine kinase
FLG15_06205	COG3437	response regulator, receiver
FLG15_06210	COG4191	Histidine kinase
FLG15_06210	COG0784	Response regulator, receiver
FLG15_06235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FLG15_06245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FLG15_06250	COG0228	four-way junction DNA binding
FLG15_06255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FLG15_06260	COG0336	Belongs to the RNA methyltransferase TrmD family
FLG15_06265	COG0335	large ribosomal subunit rRNA binding
FLG15_06295	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FLG15_06310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FLG15_06320	COG3483	tryptophan 2,3-dioxygenase activity
FLG15_06360	COG3250	beta-galactosidase activity
FLG15_06365	COG3867	Arabinogalactan endo-beta-1,4-galactanase
FLG15_06385	COG1960	acyl-CoA dehydrogenase activity
FLG15_06390	COG1024	Enoyl-CoA hydratase
FLG15_06415	COG0457	Tetratricopeptide repeat
FLG15_06425	COG0457	Tetratricopeptide repeat
FLG15_06450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FLG15_06455	COG0481	GTPase activity
FLG15_06470	COG0571	ribonuclease III activity
FLG15_06475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FLG15_06480	COG1381	Involved in DNA repair and RecF pathway recombination
FLG15_06490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FLG15_06500	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FLG15_06505	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
FLG15_06510	COG3046	protein related to deoxyribodipyrimidine photolyase
FLG15_06515	COG1472	Belongs to the glycosyl hydrolase 3 family
FLG15_06525	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FLG15_06530	COG1278	Cold shock
FLG15_06535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FLG15_06545	COG1201	RNA secondary structure unwinding
FLG15_06550	COG1793	dna ligase
FLG15_06560	COG1793	dna ligase
FLG15_06560	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FLG15_06580	COG3706	GGDEF domain
FLG15_06580	COG0745	RESPONSE REGULATOR receiver
FLG15_06600	COG0183	Belongs to the thiolase family
FLG15_06620	COG1451	nucleotide metabolic process
FLG15_06625	COG5487	UPF0391 membrane protein
FLG15_06635	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FLG15_06655	COG1077	Cell shape determining protein MreB Mrl
FLG15_06660	COG1047	Peptidyl-prolyl cis-trans
FLG15_06670	COG2824	Alkylphosphonate utilization operon protein PhnA
FLG15_06680	COG1902	pentaerythritol trinitrate reductase activity
FLG15_06685	COG2814	Major facilitator Superfamily
FLG15_06720	COG0392	lysyltransferase activity
FLG15_06720	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FLG15_06730	COG0251	oxidation-reduction process
FLG15_06735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FLG15_06750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FLG15_06775	COG1595	DNA-templated transcription, initiation
FLG15_06790	COG2878	Part of a membrane complex involved in electron transport
FLG15_06805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FLG15_06805	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FLG15_06825	COG0346	lactoylglutathione lyase activity
FLG15_06840	COG0833	amino acid
FLG15_06845	COG2040	homocysteine
FLG15_06855	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FLG15_06875	COG1695	Transcriptional regulator
FLG15_06910	COG0825	malonyl-CoA metabolic process
FLG15_06920	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FLG15_06925	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FLG15_06930	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FLG15_06935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FLG15_06940	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FLG15_06955	COG0750	zinc metalloprotease
FLG15_06960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FLG15_06965	COG0575	Belongs to the CDS family
FLG15_06970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FLG15_06975	COG0233	cytoplasmic translational termination
FLG15_06980	COG0528	UMP kinase activity
FLG15_06985	COG3706	GGDEF domain
FLG15_06985	COG0745	RESPONSE REGULATOR receiver
FLG15_06990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FLG15_06995	COG0052	Belongs to the universal ribosomal protein uS2 family
FLG15_07030	COG0024	Methionine aminopeptidase
FLG15_07035	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FLG15_07045	COG1393	Belongs to the ArsC family
FLG15_07050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FLG15_07055	COG0367	asparagine synthase
FLG15_07065	COG4774	siderophore transport
FLG15_07115	COG1566	PFAM secretion protein HlyD family protein
FLG15_07120	COG2814	Major facilitator Superfamily
FLG15_07185	COG0339	signal peptide processing
FLG15_07195	COG0386	Belongs to the glutathione peroxidase family
FLG15_07255	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FLG15_07260	COG0084	hydrolase, TatD family'
FLG15_07275	COG1960	acyl-CoA dehydrogenase activity
FLG15_07295	COG0367	asparagine synthase
FLG15_07305	COG0305	Participates in initiation and elongation during chromosome replication
FLG15_07310	COG0415	Belongs to the DNA photolyase family
FLG15_07320	COG0583	DNA-binding transcription factor activity
FLG15_07355	COG3706	GGDEF domain
FLG15_07365	COG3706	GGDEF domain
FLG15_07385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FLG15_07400	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FLG15_07410	COG0497	DNA recombination
FLG15_07415	COG1420	regulation of RNA biosynthetic process
FLG15_07420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FLG15_07425	COG0443	Heat shock 70 kDa protein
FLG15_07430	COG0484	heat shock protein binding
FLG15_07435	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FLG15_07465	COG0583	DNA-binding transcription factor activity
FLG15_07475	COG1132	(ABC) transporter
FLG15_07510	COG2850	peptidyl-arginine hydroxylation
FLG15_07535	COG1253	flavin adenine dinucleotide binding
FLG15_07570	COG1131	(ABC) transporter
FLG15_07575	COG1725	Transcriptional regulator
FLG15_07585	COG0386	Belongs to the glutathione peroxidase family
FLG15_07600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FLG15_07610	COG1410	methionine synthase
FLG15_07610	COG0646	methionine synthase
FLG15_07625	COG1960	acyl-CoA dehydrogenase activity
FLG15_07635	COG1960	acyl-CoA dehydrogenase activity
FLG15_07655	COG0557	exoribonuclease II activity
FLG15_07665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FLG15_07675	COG3706	GGDEF domain
FLG15_07680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FLG15_07690	COG0704	Plays a role in the regulation of phosphate uptake
FLG15_07695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FLG15_07700	COG0581	inorganic phosphate transmembrane transporter activity
FLG15_07705	COG0573	inorganic phosphate transmembrane transporter activity
FLG15_07710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FLG15_07735	COG0659	secondary active sulfate transmembrane transporter activity
FLG15_07740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FLG15_07750	COG1024	Enoyl-CoA hydratase
FLG15_07760	COG0494	nUDIX hydrolase
FLG15_07805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FLG15_07805	COG0116	Belongs to the methyltransferase superfamily
FLG15_07810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FLG15_07825	COG0667	Aldo Keto reductase
FLG15_07835	COG2925	Exonuclease
FLG15_07845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FLG15_07850	COG3844	kynureninase activity
FLG15_07860	COG0662	Cupin 2, conserved barrel domain protein
FLG15_07865	COG0288	reversible hydration of carbon dioxide
FLG15_07945	COG0017	Asparaginyl-tRNA synthetase
FLG15_07955	COG0316	Belongs to the HesB IscA family
FLG15_07965	COG0360	Binds together with S18 to 16S ribosomal RNA
FLG15_07970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FLG15_07985	COG3115	cell septum assembly
FLG15_07995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FLG15_08000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FLG15_08005	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FLG15_08020	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FLG15_08030	COG4993	Dehydrogenase
FLG15_08045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FLG15_08055	COG2986	histidine ammonia-lyase
FLG15_08060	COG1228	amidohydrolase
FLG15_08100	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FLG15_08105	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FLG15_08110	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FLG15_08115	COG0077	Prephenate dehydratase
FLG15_08115	COG1605	Chorismate mutase
FLG15_08120	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FLG15_08135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FLG15_08140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FLG15_08145	COG0583	DNA-binding transcription factor activity
FLG15_08160	COG0840	transmembrane signaling receptor activity
FLG15_08180	COG0784	Response regulator, receiver
FLG15_08180	COG4191	Histidine kinase
FLG15_08190	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
FLG15_08210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FLG15_08220	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FLG15_08230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FLG15_08245	COG1595	DNA-templated transcription, initiation
FLG15_08295	COG2244	polysaccharide biosynthetic process
FLG15_08325	COG2264	protein methyltransferase activity
FLG15_08335	COG0438	transferase activity, transferring glycosyl groups
FLG15_08350	COG1136	(ABC) transporter
FLG15_08360	COG0477	Major facilitator Superfamily
FLG15_08365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FLG15_08380	COG1253	flavin adenine dinucleotide binding
FLG15_08395	COG0306	phosphate transporter
FLG15_08420	COG0504	CTP synthase activity
FLG15_08425	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FLG15_08435	COG0148	phosphopyruvate hydratase activity
FLG15_08440	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FLG15_08450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FLG15_08455	COG0585	pseudouridine synthase activity
FLG15_08460	COG2840	Smr protein MutS2
FLG15_08465	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FLG15_08470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FLG15_08475	COG1238	metal cluster binding
FLG15_08485	COG3737	Protein of unknown function (DUF498/DUF598)
FLG15_08490	COG1534	Rna-binding protein
FLG15_08495	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FLG15_08500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FLG15_08505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FLG15_08510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FLG15_08515	COG1923	regulation of RNA biosynthetic process
FLG15_08520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FLG15_08525	COG1546	Belongs to the CinA family
FLG15_08535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FLG15_08540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FLG15_08550	COG2137	regulation of response to DNA damage stimulus
FLG15_08555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FLG15_08560	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FLG15_08580	COG1741	Belongs to the pirin family
FLG15_08585	COG0583	DNA-binding transcription factor activity
FLG15_08610	COG0352	thiamine-phosphate diphosphorylase activity
FLG15_08610	COG0351	phosphomethylpyrimidine kinase
FLG15_08625	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FLG15_08630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FLG15_08645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FLG15_08655	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FLG15_08660	COG3734	2-keto-3-deoxy-galactonokinase
FLG15_08670	COG4948	Mandelate Racemase Muconate Lactonizing
FLG15_08675	COG0800	Aldolase
FLG15_08715	COG1501	Belongs to the glycosyl hydrolase 31 family
FLG15_08725	COG1070	Carbohydrate kinase
FLG15_08730	COG2115	Belongs to the xylose isomerase family
FLG15_08735	COG0477	Major facilitator Superfamily
FLG15_08755	COG0860	N-Acetylmuramoyl-L-alanine amidase
FLG15_08760	COG1469	GTP cyclohydrolase I activity
FLG15_08785	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FLG15_08790	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FLG15_08795	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FLG15_08800	COG0166	Belongs to the GPI family
FLG15_08825	COG1472	Belongs to the glycosyl hydrolase 3 family
FLG15_08840	COG5001	Diguanylate cyclase
FLG15_08840	COG3706	GGDEF domain
FLG15_08840	COG4251	negative regulation of phosphorylation
FLG15_08840	COG2203	Gaf domain
FLG15_08845	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FLG15_08850	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FLG15_08865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FLG15_08870	COG0671	phosphoesterase, PA-phosphatase related
FLG15_08880	COG1794	racemase activity, acting on amino acids and derivatives
FLG15_08890	COG0697	spore germination
FLG15_08895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FLG15_08900	COG0167	dihydroorotate dehydrogenase activity
FLG15_08920	COG1012	belongs to the aldehyde dehydrogenase family
FLG15_08980	COG0840	transmembrane signaling receptor activity
FLG15_09040	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FLG15_09050	COG0527	aspartate kinase activity
FLG15_09050	COG0460	homoserine dehydrogenase
FLG15_09075	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FLG15_09085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FLG15_09090	COG0124	histidyl-tRNA synthetase
FLG15_09120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FLG15_09125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FLG15_09130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FLG15_09135	COG0131	Imidazoleglycerol-phosphate dehydratase
FLG15_09135	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FLG15_09140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FLG15_09145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FLG15_09150	COG0107	imidazoleglycerol-phosphate synthase activity
FLG15_09155	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FLG15_09155	COG0140	phosphoribosyl-ATP diphosphatase activity
FLG15_09170	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FLG15_09175	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FLG15_09180	COG0235	Class ii aldolase
FLG15_09185	COG0531	amino acid
FLG15_09190	COG0531	amino acid
FLG15_09200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FLG15_09205	COG0277	FAD linked oxidase domain protein
FLG15_09225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FLG15_09270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FLG15_09275	COG2258	MOSC domain
FLG15_09280	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FLG15_09285	COG0505	Belongs to the CarA family
FLG15_09300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FLG15_09305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FLG15_09315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FLG15_09325	COG3279	Response regulator of the LytR AlgR family
FLG15_09335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FLG15_09350	COG2205	protein histidine kinase activity
FLG15_09350	COG2198	Histidine kinase
FLG15_09350	COG0784	Response regulator, receiver
FLG15_09355	COG1024	Enoyl-CoA hydratase
FLG15_09360	COG0318	PFAM AMP-dependent synthetase and ligase
FLG15_09395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FLG15_09405	COG2201	protein-glutamate methylesterase activity
FLG15_09410	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FLG15_09420	COG0840	transmembrane signaling receptor activity
FLG15_09430	COG0835	chemotaxis
FLG15_09450	COG0840	transmembrane signaling receptor activity
FLG15_09465	COG0840	transmembrane signaling receptor activity
FLG15_09480	COG0840	transmembrane signaling receptor activity
FLG15_09485	COG0840	transmembrane signaling receptor activity
FLG15_09490	COG0840	transmembrane signaling receptor activity
FLG15_09505	COG0840	transmembrane signaling receptor activity
FLG15_09510	COG0840	transmembrane signaling receptor activity
FLG15_09530	COG0745	RESPONSE REGULATOR receiver
FLG15_09540	COG0835	chemotaxis
FLG15_09545	COG1192	Involved in chromosome partitioning
FLG15_09550	COG1360	Flagellar Motor Protein
FLG15_09555	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FLG15_09615	COG0643	Histidine kinase
FLG15_09615	COG2198	Histidine kinase
FLG15_09635	COG0455	bacterial-type flagellum organization
FLG15_09645	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FLG15_09665	COG5001	Diguanylate cyclase
FLG15_09665	COG3300	MHYT domain
FLG15_09675	COG5001	Diguanylate cyclase
FLG15_09675	COG3300	MHYT domain
FLG15_09680	COG1684	flagellar biosynthetic protein fliR
FLG15_09685	COG1987	bacterial-type flagellum assembly
FLG15_09700	COG3190	flagellar
FLG15_09750	COG1677	Flagellar hook-basal body complex protein FliE
FLG15_09770	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FLG15_09800	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_09805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FLG15_09820	COG2204	response regulator
FLG15_09825	COG2201	protein-glutamate methylesterase activity
FLG15_09855	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FLG15_09875	COG3951	Flagellar rod assembly protein muramidase FlgJ
FLG15_09875	COG1705	Flagellar rod assembly protein muramidase FlgJ
FLG15_09880	COG1706	bacterial-type flagellum-dependent cell motility
FLG15_09885	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FLG15_09890	COG4786	Flagellar basal body rod
FLG15_09900	COG4787	bacterial-type flagellum-dependent cell motility
FLG15_09910	COG1749	Flagellar hook protein flgE
FLG15_09915	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FLG15_09920	COG1558	bacterial-type flagellum-dependent cell motility
FLG15_09930	COG0784	Response regulator, receiver
FLG15_09930	COG0835	chemotaxis
FLG15_09950	COG5002	protein histidine kinase activity
FLG15_09960	COG4585	Histidine kinase
FLG15_09980	COG2915	High frequency lysogenization protein hflD homolog
FLG15_09985	COG0482	sulfurtransferase activity
FLG15_09995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FLG15_10000	COG0542	response to heat
FLG15_10005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FLG15_10010	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FLG15_10020	COG0492	ferredoxin-NADP+ reductase activity
FLG15_10025	COG1674	ftsk spoiiie
FLG15_10035	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FLG15_10045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FLG15_10050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FLG15_10055	COG0183	Belongs to the thiolase family
FLG15_10060	COG1250	3-hydroxyacyl-CoA dehydrogenase
FLG15_10060	COG1024	Enoyl-CoA hydratase
FLG15_10070	COG0105	UTP biosynthetic process
FLG15_10095	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FLG15_10100	COG1160	GTP binding
FLG15_10105	COG0303	'Molybdopterin
FLG15_10110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FLG15_10145	COG0708	Exodeoxyribonuclease III
FLG15_10155	COG0303	'Molybdopterin
FLG15_10160	COG0746	molybdenum cofactor guanylyltransferase activity
FLG15_10175	COG4221	oxidoreductase activity
FLG15_10185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FLG15_10185	COG1648	precorrin-2 dehydrogenase activity
FLG15_10195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FLG15_10205	COG2223	nitrite transmembrane transporter activity
FLG15_10210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FLG15_10220	COG0243	molybdopterin cofactor binding
FLG15_10240	COG3685	Protein conserved in bacteria
FLG15_10260	COG5001	Diguanylate cyclase
FLG15_10270	COG4566	intracellular signal transduction
FLG15_10330	COG1238	metal cluster binding
FLG15_10350	COG1714	RDD family
FLG15_10375	COG2207	Transcriptional regulator
FLG15_10380	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_10450	COG3501	Rhs element vgr protein
FLG15_10485	COG0631	protein serine/threonine phosphatase activity
FLG15_10490	COG0515	serine threonine protein kinase
FLG15_10520	COG1858	cytochrome C peroxidase
FLG15_10555	COG0640	Transcriptional regulator
FLG15_10585	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_10590	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FLG15_10595	COG1073	alpha beta
FLG15_10595	COG2226	methyltransferase
FLG15_10610	COG0363	glucosamine-6-phosphate deaminase activity
FLG15_10635	COG0596	Alpha beta hydrolase
FLG15_10645	COG1309	transcriptional regulator
FLG15_10660	COG2154	pterin-4-alpha-carbinolamine dehydratase
FLG15_10670	COG0428	transporter
FLG15_10675	COG3064	Membrane
FLG15_10685	COG1530	ribonuclease E activity
FLG15_10715	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FLG15_10740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FLG15_10745	COG0322	excinuclease ABC activity
FLG15_10755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FLG15_10760	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FLG15_10765	COG1663	tetraacyldisaccharide 4'-kinase activity
FLG15_10770	COG1132	(ABC) transporter
FLG15_10780	COG0811	peptide transport
FLG15_10795	COG1136	(ABC) transporter
FLG15_10800	COG4591	ABC-type transport system involved in lipoprotein release permease component
FLG15_10810	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FLG15_10815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FLG15_10830	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FLG15_10845	COG0354	folic acid binding
FLG15_10855	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FLG15_10860	COG0837	glucose binding
FLG15_10865	COG0363	glucosamine-6-phosphate deaminase activity
FLG15_10870	COG0129	dihydroxy-acid dehydratase activity
FLG15_10875	COG0800	Aldolase
FLG15_10950	COG0784	Response regulator, receiver
FLG15_10950	COG2205	protein histidine kinase activity
FLG15_10955	COG2183	response to ionizing radiation
FLG15_10965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FLG15_10965	COG0723	plastoquinol--plastocyanin reductase activity
FLG15_10980	COG3243	poly(R)-hydroxyalkanoic acid synthase
FLG15_10990	COG1183	phosphatidylcholine synthase activity
FLG15_10995	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_11010	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FLG15_11020	COG0668	transmembrane transport
FLG15_11025	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FLG15_11030	COG0590	tRNA wobble adenosine to inosine editing
FLG15_11035	COG1321	iron dependent repressor
FLG15_11040	COG1914	H( )-stimulated, divalent metal cation uptake system
FLG15_11060	COG2814	Major facilitator Superfamily
FLG15_11075	COG1335	isochorismatase
FLG15_11090	COG2197	response regulator
FLG15_11120	COG0583	DNA-binding transcription factor activity
FLG15_11125	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FLG15_11130	COG3002	Belongs to the UPF0753 family
FLG15_11145	COG3384	dioxygenase
FLG15_11190	COG3093	addiction module antidote protein HigA
FLG15_11220	COG4774	siderophore transport
FLG15_11240	COG2336	PFAM SpoVT AbrB
FLG15_11265	COG4206	TonB-dependent receptor
FLG15_11315	COG1192	Involved in chromosome partitioning
FLG15_11355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FLG15_11360	COG0270	DNA (cytosine-5-)-methyltransferase activity
FLG15_11535	COG0210	DNA helicase
FLG15_11610	COG2084	Dehydrogenase
FLG15_11630	COG2003	Belongs to the UPF0758 family
FLG15_11680	COG0582	viral genome integration into host DNA
FLG15_11685	COG0519	Catalyzes the synthesis of GMP from XMP
FLG15_11685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FLG15_11695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FLG15_11710	COG0475	glutathione-regulated potassium exporter activity
FLG15_11710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FLG15_11720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FLG15_11730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FLG15_11735	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FLG15_11745	COG0776	regulation of translation
FLG15_11750	COG0539	negative regulation of cytoplasmic translation
FLG15_11755	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FLG15_11760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FLG15_11770	COG2957	Belongs to the agmatine deiminase family
FLG15_11775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FLG15_11800	COG0395	ABC-type sugar transport system, permease component
FLG15_11805	COG1175	transmembrane transport
FLG15_11835	COG2350	Protein conserved in bacteria
FLG15_11840	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FLG15_11845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FLG15_11850	COG1187	pseudouridine synthase activity
FLG15_11870	COG0436	Aminotransferase
FLG15_11875	COG4133	protoheme IX ABC transporter activity
FLG15_11895	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FLG15_11925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FLG15_11930	COG1278	Cold shock
FLG15_11935	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FLG15_11940	COG4988	ABC transporter
FLG15_11950	COG1294	oxidase, subunit
FLG15_11980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FLG15_11985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FLG15_11995	COG0165	Argininosuccinate lyase
FLG15_12000	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FLG15_12010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FLG15_12025	COG0137	argininosuccinate synthase activity
FLG15_12030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FLG15_12040	COG0215	cysteine-tRNA ligase activity
FLG15_12045	COG2166	iron-sulfur cluster assembly
FLG15_12055	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FLG15_12065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FLG15_12090	COG4303	Ethanolamine ammonia lyase large subunit
FLG15_12095	COG4302	ethanolamine ammonia-lyase activity
FLG15_12120	COG4677	pectinesterase activity
FLG15_12140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FLG15_12145	COG0402	S-adenosylhomocysteine deaminase activity
FLG15_12155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FLG15_12160	COG1509	lysine 2,3-aminomutase activity
FLG15_12165	COG5001	Diguanylate cyclase
FLG15_12165	COG3300	MHYT domain
FLG15_12180	COG0483	inositol monophosphate 1-phosphatase activity
FLG15_12210	COG0513	Belongs to the DEAD box helicase family
FLG15_12215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FLG15_12220	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FLG15_12230	COG0625	glutathione transferase activity
FLG15_12240	COG4681	YaeQ
FLG15_12245	COG2081	HI0933 family
FLG15_12255	COG0501	Belongs to the peptidase M48B family
FLG15_12260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FLG15_12265	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_12290	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FLG15_12295	COG0860	N-Acetylmuramoyl-L-alanine amidase
FLG15_12300	COG0802	atpase or kinase
FLG15_12305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FLG15_12305	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FLG15_12310	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FLG15_12315	COG1570	exodeoxyribonuclease VII activity
FLG15_12330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FLG15_12405	COG0835	chemotaxis
FLG15_12410	COG0840	transmembrane signaling receptor activity
FLG15_12415	COG2094	Belongs to the DNA glycosylase MPG family
FLG15_12420	COG1201	RNA secondary structure unwinding
FLG15_12440	COG2969	positive regulation of protein catabolic process
FLG15_12445	COG0625	glutathione transferase activity
FLG15_12450	COG2857	Cytochrome c1
FLG15_12455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FLG15_12460	COG0723	plastoquinol--plastocyanin reductase activity
FLG15_12470	COG0741	lytic transglycosylase activity
FLG15_12485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FLG15_12490	COG1702	phosphate starvation-inducible protein PhoH
FLG15_12500	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FLG15_12510	COG4535	Mg2 and Co2 transporter CorC
FLG15_12525	COG1012	belongs to the aldehyde dehydrogenase family
FLG15_12530	COG1177	transmembrane transport
FLG15_12535	COG1176	ABC-type spermidine putrescine transport system, permease component I
FLG15_12540	COG3842	ATPase activity
FLG15_12560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FLG15_12585	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FLG15_12590	COG0174	glutamine synthetase
FLG15_12595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FLG15_12600	COG3706	GGDEF domain
FLG15_12600	COG0745	RESPONSE REGULATOR receiver
FLG15_12605	COG2703	oxygen carrier activity
FLG15_12610	COG0477	Major facilitator Superfamily
FLG15_12620	COG0243	molybdopterin cofactor binding
FLG15_12625	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FLG15_12655	COG2733	membrane
FLG15_12660	COG0784	Response regulator, receiver
FLG15_12660	COG2205	protein histidine kinase activity
FLG15_12660	COG5002	protein histidine kinase activity
FLG15_12670	COG0477	Major facilitator Superfamily
FLG15_12675	COG2902	Dehydrogenase
FLG15_12685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FLG15_12690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FLG15_12695	COG1609	Transcriptional regulator
FLG15_12700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FLG15_12700	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FLG15_12705	COG1105	Belongs to the carbohydrate kinase PfkB family
FLG15_12710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FLG15_12710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FLG15_12770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FLG15_12780	COG1862	Preprotein translocase
FLG15_12785	COG0343	queuine tRNA-ribosyltransferase activity
FLG15_12790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FLG15_12840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FLG15_12845	COG3291	Pkd domain containing protein
FLG15_12850	COG0405	Gamma-glutamyltransferase
FLG15_12855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FLG15_12870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FLG15_12875	COG0742	ribosomal rna small subunit methyltransferase
FLG15_12880	COG0326	Molecular chaperone. Has ATPase activity
FLG15_12980	COG0531	amino acid
FLG15_13000	COG0006	proline dipeptidase activity
FLG15_13010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FLG15_13025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FLG15_13030	COG3938	Belongs to the proline racemase family
FLG15_13040	COG0552	protein localization to endoplasmic reticulum
FLG15_13050	COG1194	a g-specific adenine glycosylase
FLG15_13070	COG4191	Histidine kinase
FLG15_13070	COG0784	Response regulator, receiver
FLG15_13100	COG3040	lipid binding
FLG15_13110	COG1960	acyl-CoA dehydrogenase activity
FLG15_13120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FLG15_13140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FLG15_13150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FLG15_13185	COG0438	transferase activity, transferring glycosyl groups
FLG15_13190	COG0438	transferase activity, transferring glycosyl groups
FLG15_13235	COG0776	regulation of translation
FLG15_13240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FLG15_13240	COG0072	phenylalanine-tRNA ligase activity
FLG15_13245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FLG15_13250	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FLG15_13255	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FLG15_13260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FLG15_13265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FLG15_13285	COG2211	Major facilitator Superfamily
FLG15_13295	COG1082	Xylose isomerase domain protein TIM barrel
FLG15_13320	COG3505	Type IV secretory pathway VirD4
FLG15_13340	COG2948	multi-organism process
FLG15_13360	COG3702	type iv secretory pathway
FLG15_13370	COG0366	Alpha amylase catalytic
FLG15_13390	COG0556	nucleotide-excision repair
FLG15_13395	COG4969	Belongs to the N-Me-Phe pilin family
FLG15_13435	COG1611	Belongs to the LOG family
FLG15_13450	COG2095	MarC family integral membrane protein
FLG15_13460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FLG15_13465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FLG15_13495	COG1185	polyribonucleotide nucleotidyltransferase activity
FLG15_13500	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FLG15_13505	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FLG15_13510	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FLG15_13515	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FLG15_13520	COG0195	Participates in both transcription termination and antitermination
FLG15_13525	COG0779	Required for maturation of 30S ribosomal subunits
FLG15_13535	COG1007	ATP synthesis coupled electron transport
FLG15_13550	COG0713	ATP synthesis coupled electron transport
FLG15_13560	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FLG15_13565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FLG15_13575	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FLG15_13580	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FLG15_13585	COG0649	NAD binding
FLG15_13590	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FLG15_13595	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FLG15_13600	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FLG15_13615	COG0149	triose-phosphate isomerase activity
FLG15_13650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FLG15_13655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FLG15_13660	COG0159	tryptophan synthase activity
FLG15_13670	COG0133	tryptophan synthase activity
FLG15_13680	COG0135	phosphoribosylanthranilate isomerase activity
FLG15_13685	COG0101	tRNA pseudouridine synthase activity
FLG15_13700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FLG15_13705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FLG15_13710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FLG15_13715	COG2890	protein-(glutamine-N5) methyltransferase activity
FLG15_13725	COG0688	phosphatidylethanolamine metabolic process
FLG15_13740	COG0433	COG0433 Predicted ATPase
FLG15_13750	COG0494	nUDIX hydrolase
FLG15_13770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FLG15_13775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FLG15_13805	COG0717	Belongs to the dCTP deaminase family
FLG15_13815	COG0489	protein tyrosine kinase activity
FLG15_13835	COG3590	peptidase
FLG15_13840	COG3590	peptidase
FLG15_13860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FLG15_13865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FLG15_13870	COG2311	Membrane
FLG15_13875	COG1047	Peptidyl-prolyl cis-trans
FLG15_13880	COG0791	NLP P60 protein
FLG15_13885	COG0791	NLP P60 protein
FLG15_13900	COG1301	dicarboxylic acid transport
FLG15_13905	COG1785	Belongs to the alkaline phosphatase family
FLG15_13915	COG0037	tRNA processing
FLG15_13920	COG1722	exodeoxyribonuclease VII activity
FLG15_13925	COG0142	geranyltranstransferase activity
FLG15_13935	COG4104	PAAR repeat-containing protein
FLG15_13945	COG0312	modulator of DNA gyrase
FLG15_13950	COG3028	Belongs to the UPF0307 family
FLG15_13955	COG0312	modulator of DNA gyrase
FLG15_13965	COG3164	Protein of unknown function
FLG15_13970	COG1530	ribonuclease E activity
FLG15_13975	COG0424	maF-like protein
FLG15_13980	COG2968	Membrane
FLG15_13995	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FLG15_14010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FLG15_14025	COG0495	leucyl-tRNA aminoacylation
FLG15_14035	COG3118	belongs to the thioredoxin family
FLG15_14060	COG2155	Conserved Protein
FLG15_14065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FLG15_14140	COG0745	RESPONSE REGULATOR receiver
FLG15_14145	COG5002	protein histidine kinase activity
FLG15_14145	COG5000	phosphorelay sensor kinase activity
FLG15_14150	COG0475	glutathione-regulated potassium exporter activity
FLG15_14155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FLG15_14160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FLG15_14175	COG3706	GGDEF domain
FLG15_14175	COG0745	RESPONSE REGULATOR receiver
FLG15_14180	COG1187	pseudouridine synthase activity
FLG15_14185	COG5002	protein histidine kinase activity
FLG15_14185	COG5001	Diguanylate cyclase
FLG15_14305	COG0667	Aldo Keto reductase
FLG15_14310	COG2814	Major facilitator Superfamily
FLG15_14315	COG0583	DNA-binding transcription factor activity
FLG15_14325	COG2207	Transcriptional regulator
FLG15_14335	COG1309	transcriptional regulator
FLG15_14340	COG1538	Outer membrane efflux protein
FLG15_14345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FLG15_14360	COG0735	belongs to the Fur family
FLG15_14365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FLG15_14390	COG4452	Inner membrane protein CreD
FLG15_14400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FLG15_14405	COG2205	protein histidine kinase activity
FLG15_14410	COG0745	RESPONSE REGULATOR receiver
FLG15_14415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FLG15_14430	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FLG15_14440	COG2198	Histidine kinase
FLG15_14440	COG0643	Histidine kinase
FLG15_14445	COG0840	transmembrane signaling receptor activity
FLG15_14450	COG0835	chemotaxis
FLG15_14455	COG2199	diguanylate cyclase activity
FLG15_14455	COG2202	Pas domain
FLG15_14455	COG2200	EAL domain
FLG15_14460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FLG15_14465	COG2201	protein-glutamate methylesterase activity
FLG15_14470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FLG15_14475	COG3590	peptidase
FLG15_14485	COG0588	phosphoglycerate mutase activity
FLG15_14490	COG1515	deoxyribonuclease V activity
FLG15_14500	COG1741	Belongs to the pirin family
FLG15_14515	COG1741	Belongs to the pirin family
FLG15_14520	COG1966	Carbon starvation protein
FLG15_14525	COG2879	small protein
FLG15_14565	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FLG15_14570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FLG15_14575	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FLG15_14580	COG2080	2 iron, 2 sulfur cluster binding
FLG15_14585	COG0604	alcohol dehydrogenase
FLG15_14585	COG3321	synthase
FLG15_14585	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_14590	COG2203	Gaf domain
FLG15_14590	COG5001	Diguanylate cyclase
FLG15_14590	COG4251	negative regulation of phosphorylation
FLG15_14590	COG3706	GGDEF domain
FLG15_14595	COG0629	single-stranded DNA binding
FLG15_14600	COG0142	geranyltranstransferase activity
FLG15_14610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FLG15_14625	COG0527	aspartate kinase activity
FLG15_14630	COG0384	phenazine biosynthesis protein PhzF
FLG15_14635	COG0384	phenazine biosynthesis protein PhzF
FLG15_14645	COG1764	response to oxidative stress
FLG15_14650	COG0540	Belongs to the ATCase OTCase family
FLG15_14655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FLG15_14660	COG1678	Uncharacterized ACR, COG1678
FLG15_14665	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FLG15_14670	COG0519	Catalyzes the synthesis of GMP from XMP
FLG15_14695	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FLG15_14710	COG0739	heme binding
FLG15_14730	COG0693	protein deglycase activity
FLG15_14740	COG1959	2 iron, 2 sulfur cluster binding
FLG15_14745	COG0719	Fe-S assembly protein
FLG15_14750	COG0396	ATPase activity
FLG15_14755	COG0719	Fe-S assembly protein
FLG15_14760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FLG15_14765	COG0456	acetyltransferase
FLG15_14775	COG4774	siderophore transport
FLG15_14780	COG3128	pkhd-type hydroxylase
FLG15_14805	COG1477	protein flavinylation
FLG15_14820	COG1555	photosystem II stabilization
FLG15_14825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FLG15_14840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FLG15_14850	COG0628	permease
FLG15_14860	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FLG15_14875	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FLG15_14895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FLG15_14900	COG0271	Belongs to the BolA IbaG family
FLG15_14910	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FLG15_14920	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FLG15_14925	COG1137	ATPase activity
FLG15_14940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FLG15_14945	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FLG15_14950	COG1660	Displays ATPase and GTPase activities
FLG15_14960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FLG15_14965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FLG15_14975	COG2239	Acts as a magnesium transporter
FLG15_14985	COG1294	oxidase, subunit
FLG15_14990	COG1271	oxidase subunit
FLG15_15000	COG1113	amino acid transport
FLG15_15025	COG2197	response regulator
FLG15_15030	COG0531	amino acid
FLG15_15095	COG2814	Major facilitator Superfamily
FLG15_15105	COG0754	glutathionylspermidine amidase activity
FLG15_15130	COG1842	Phage shock protein A
FLG15_15140	COG0259	pyridoxamine-phosphate oxidase activity
FLG15_15145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FLG15_15150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FLG15_15160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FLG15_15165	COG2814	Major facilitator Superfamily
FLG15_15195	COG2205	protein histidine kinase activity
FLG15_15195	COG2198	Histidine kinase
FLG15_15195	COG0784	Response regulator, receiver
FLG15_15200	COG2353	YceI-like domain
FLG15_15220	COG1760	l-serine dehydratase
FLG15_15230	COG0460	homoserine dehydrogenase
FLG15_15230	COG0527	aspartate kinase activity
FLG15_15235	COG0626	cystathionine gamma-synthase activity
FLG15_15240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FLG15_15245	COG0739	heme binding
FLG15_15250	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FLG15_15255	COG1272	protein, Hemolysin III
FLG15_15265	COG0516	GMP reductase activity
FLG15_15265	COG0517	IMP dehydrogenase activity
FLG15_15270	COG0463	Glycosyl transferase, family 2
FLG15_15275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FLG15_15280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FLG15_15295	COG1309	transcriptional regulator
FLG15_15305	COG1960	acyl-CoA dehydrogenase activity
FLG15_15340	COG0509	glycine decarboxylation via glycine cleavage system
FLG15_15345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FLG15_15355	COG0330	HflC and HflK could
FLG15_15360	COG1742	UPF0060 membrane protein
FLG15_15365	COG3956	TIGRFAM MazG family protein
FLG15_15375	COG0494	nUDIX hydrolase
FLG15_15385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FLG15_15390	COG0837	glucose binding
FLG15_15405	COG1388	LysM domain
FLG15_15405	COG3858	chitin binding
FLG15_15425	COG1472	Belongs to the glycosyl hydrolase 3 family
FLG15_15435	COG3537	Alpha-1,2-mannosidase
FLG15_15475	COG3142	Participates in the control of copper homeostasis
FLG15_15480	COG1446	asparaginase
FLG15_15515	COG0840	transmembrane signaling receptor activity
FLG15_15520	COG0835	chemotaxis
FLG15_15535	COG0189	ligase activity
FLG15_15555	COG1199	ATP-dependent helicase activity
FLG15_15565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FLG15_15570	COG1215	transferase activity, transferring glycosyl groups
FLG15_15585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FLG15_15595	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FLG15_15600	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FLG15_15605	COG0535	radical SAM domain protein
FLG15_15635	COG1643	Atp-dependent helicase
FLG15_15640	COG0783	Belongs to the Dps family
FLG15_15650	COG0514	ATP-dependent DNA helicase (RecQ)
FLG15_15660	COG2197	response regulator
FLG15_15690	COG0840	transmembrane signaling receptor activity
FLG15_15710	COG3920	Histidine kinase
FLG15_15725	COG0602	queuosine metabolic process
FLG15_15735	COG2885	chlorophyll binding
FLG15_15740	COG0823	Involved in the tonB-independent uptake of proteins
FLG15_15750	COG0848	biopolymer transport protein
FLG15_15760	COG0824	Thioesterase
FLG15_15765	COG2255	four-way junction helicase activity
FLG15_15775	COG3158	transport of potassium into the cell
FLG15_15780	COG0632	four-way junction helicase activity
FLG15_15785	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FLG15_15790	COG0217	transcriptional regulatory protein
FLG15_15810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FLG15_15825	COG0477	Major facilitator Superfamily
FLG15_15865	COG0488	(ABC) transporter
FLG15_15900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FLG15_15900	COG4651	solute:proton antiporter activity
FLG15_15925	COG4772	TonB-dependent receptor
FLG15_15935	COG4264	IucA IucC family
FLG15_15950	COG0019	diaminopimelate decarboxylase activity
FLG15_15970	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FLG15_15980	COG1492	cobalamin metabolic process
FLG15_15990	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FLG15_16015	COG4206	TonB-dependent receptor
FLG15_16025	COG0542	response to heat
FLG15_16070	COG1877	trehalose-phosphatase activity
FLG15_16075	COG3387	PFAM Glycoside hydrolase 15-related
FLG15_16095	COG0840	transmembrane signaling receptor activity
FLG15_16100	COG3011	Protein conserved in bacteria
FLG15_16115	COG0564	pseudouridine synthase activity
FLG15_16120	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FLG15_16130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FLG15_16130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FLG15_16145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FLG15_16150	COG0045	succinate-CoA ligase (ADP-forming) activity
FLG15_16185	COG4969	Belongs to the N-Me-Phe pilin family
FLG15_16195	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FLG15_16200	COG0237	dephospho-CoA kinase activity
FLG15_16235	COG0745	RESPONSE REGULATOR receiver
FLG15_16245	COG0189	ligase activity
FLG15_16270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FLG15_16315	COG2022	thiamine diphosphate biosynthetic process
FLG15_16320	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FLG15_16325	COG3273	potassium ion transport
FLG15_16325	COG0471	metal ion transport
FLG15_16350	COG1970	mechanosensitive ion channel activity
FLG15_16360	COG1609	Transcriptional regulator
FLG15_16375	COG3250	beta-galactosidase activity
FLG15_16380	COG4948	Mandelate Racemase Muconate Lactonizing
FLG15_16390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FLG15_16400	COG0308	aminopeptidase N
FLG15_16405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FLG15_16420	COG0529	Catalyzes the synthesis of activated sulfate
FLG15_16420	COG2895	sulfate adenylyltransferase (ATP) activity
FLG15_16425	COG0175	sulfate reduction
FLG15_16430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FLG15_16435	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FLG15_16440	COG0175	sulfate reduction
FLG15_16480	COG1648	precorrin-2 dehydrogenase activity
FLG15_16480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FLG15_16495	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FLG15_16500	COG3588	fructose-bisphosphate aldolase
FLG15_16510	COG0469	pyruvate kinase activity
FLG15_16520	COG0126	phosphoglycerate kinase activity
FLG15_16540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FLG15_16550	COG3047	cAMP biosynthetic process
FLG15_16565	COG3453	Protein conserved in bacteria
FLG15_16565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FLG15_16570	COG0725	ABC transporter, periplasmic molybdate-binding protein
FLG15_16575	COG4149	molybdate abc transporter
FLG15_16580	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FLG15_16600	COG0642	Histidine kinase
FLG15_16605	COG0745	RESPONSE REGULATOR receiver
FLG15_16625	COG1022	Amp-dependent synthetase and ligase
FLG15_16650	COG1376	ErfK ybiS ycfS ynhG family protein
FLG15_16655	COG0739	heme binding
FLG15_16660	COG4773	Receptor
FLG15_16675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FLG15_16685	COG1301	dicarboxylic acid transport
FLG15_16695	COG2304	oxidoreductase activity
FLG15_16715	COG0714	Associated with various cellular activities
FLG15_16745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FLG15_16760	COG0254	rRNA binding
FLG15_16765	COG1957	nucleoside hydrolase
FLG15_16770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FLG15_16780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FLG15_16785	COG1758	RNA polymerase activity
FLG15_16795	COG1561	YicC-like family, N-terminal region
FLG15_16800	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FLG15_16805	COG0346	lactoylglutathione lyase activity
FLG15_16810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FLG15_16815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FLG15_16830	COG0006	proline dipeptidase activity
FLG15_16840	COG0006	proline dipeptidase activity
FLG15_16845	COG3079	Belongs to the UPF0149 family
FLG15_16865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FLG15_16885	COG2912	Transglutaminase-like superfamily
FLG15_16890	COG1773	rubredoxin
FLG15_16895	COG0352	thiamine-phosphate diphosphorylase activity
FLG15_16910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FLG15_16920	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
FLG15_16955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FLG15_16960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FLG15_16970	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_16980	COG0671	phosphoesterase, PA-phosphatase related
FLG15_16985	COG3781	membrane
FLG15_16995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FLG15_17000	COG0563	adenylate kinase activity
FLG15_17015	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FLG15_17025	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FLG15_17045	COG3710	Transcriptional regulator
FLG15_17050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FLG15_17070	COG0405	Gamma-glutamyltransferase
FLG15_17075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FLG15_17095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FLG15_17100	COG0473	3-isopropylmalate dehydrogenase activity
FLG15_17105	COG0066	3-isopropylmalate dehydratase activity
FLG15_17110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FLG15_17130	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FLG15_17135	COG1538	Outer membrane efflux protein
FLG15_17140	COG1519	Transferase
FLG15_17145	COG1560	Kdo2-lipid A biosynthetic process
FLG15_17170	COG0280	phosphate acetyltransferase
FLG15_17170	COG0281	malic enzyme
FLG15_17175	COG1301	dicarboxylic acid transport
FLG15_17200	COG0583	DNA-binding transcription factor activity
FLG15_17210	COG0667	Aldo Keto reductase
FLG15_17225	COG2197	response regulator
FLG15_17235	COG1840	ABC-type Fe3 transport system, periplasmic component
FLG15_17240	COG0642	Histidine kinase
FLG15_17260	COG2851	Citrate transporter
FLG15_17265	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_17270	COG1609	Transcriptional regulator
FLG15_17280	COG2211	Major facilitator Superfamily
FLG15_17305	COG1162	GTPase activity
FLG15_17330	COG0436	Aminotransferase
FLG15_17350	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FLG15_17365	COG3964	amidohydrolase
FLG15_17370	COG0402	S-adenosylhomocysteine deaminase activity
FLG15_17390	COG0457	Tetratricopeptide repeat
FLG15_17395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FLG15_17400	COG1215	transferase activity, transferring glycosyl groups
FLG15_17405	COG1215	transferase activity, transferring glycosyl groups
FLG15_17420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FLG15_17465	COG2188	Transcriptional regulator
FLG15_17480	COG1450	Type ii and iii secretion system protein
FLG15_17495	COG3166	PFAM Fimbrial assembly family protein
FLG15_17500	COG3156	type II secretion system protein K
FLG15_17505	COG4795	General secretion pathway protein
FLG15_17510	COG2165	general secretion pathway protein
FLG15_17515	COG4970	Tfp pilus assembly protein FimT
FLG15_17520	COG2165	general secretion pathway protein
FLG15_17525	COG1459	type II secretion system
FLG15_17530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FLG15_17535	COG1404	Belongs to the peptidase S8 family
FLG15_17540	COG5295	Hep Hag repeat protein
FLG15_17545	COG1404	Belongs to the peptidase S8 family
FLG15_17550	COG5295	Hep Hag repeat protein
FLG15_17555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FLG15_17555	COG0047	phosphoribosylformylglycinamidine synthase activity
FLG15_17560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FLG15_17575	COG4974	Belongs to the 'phage' integrase family
FLG15_17590	COG0795	lipopolysaccharide-transporting ATPase activity
FLG15_17600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FLG15_17615	COG0525	valine-tRNA ligase activity
FLG15_17650	COG1183	phosphatidylcholine synthase activity
FLG15_17660	COG0442	prolyl-tRNA aminoacylation
FLG15_17675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FLG15_17680	COG1127	ABC transporter
FLG15_17685	COG3218	ABC-type transport auxiliary lipoprotein component
FLG15_17685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FLG15_17720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FLG15_17725	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FLG15_17725	COG0662	Cupin 2, conserved barrel domain protein
FLG15_17755	COG2086	electron transfer activity
FLG15_17770	COG0546	phosphoglycolate phosphatase activity
FLG15_17770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FLG15_17775	COG0277	FAD linked oxidase domain protein
FLG15_17795	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FLG15_17840	COG1216	Glycosyl transferase, family 2
FLG15_17840	COG0438	transferase activity, transferring glycosyl groups
FLG15_17860	COG0626	cystathionine gamma-synthase activity
FLG15_17890	COG0625	glutathione transferase activity
FLG15_17905	COG0513	Belongs to the DEAD box helicase family
FLG15_17910	COG0720	synthase
FLG15_17920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FLG15_17930	COG1956	GAF domain-containing protein
FLG15_17945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FLG15_17950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FLG15_17970	COG0339	signal peptide processing
FLG15_17985	COG2132	Multicopper oxidase
FLG15_18020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FLG15_18025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FLG15_18030	COG1136	(ABC) transporter
FLG15_18035	COG1136	(ABC) transporter
FLG15_18035	COG0577	efflux transmembrane transporter activity
FLG15_18050	COG2204	response regulator
FLG15_18060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FLG15_18075	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FLG15_18080	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FLG15_18085	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FLG15_18095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FLG15_18100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FLG15_18110	COG0356	it plays a direct role in the translocation of protons across the membrane
FLG15_18130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FLG15_18140	COG0508	dehydrogenase complex catalyzes the overall conversion of
FLG15_18180	COG2011	ABC-type metal ion transport system permease component
FLG15_18185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FLG15_18190	COG0697	spore germination
FLG15_18195	COG1666	GTP binding
FLG15_18205	COG5002	protein histidine kinase activity
FLG15_18205	COG2198	Histidine kinase
FLG15_18205	COG0784	Response regulator, receiver
FLG15_18245	COG1187	pseudouridine synthase activity
FLG15_18250	COG2813	Specifically methylates the guanine in position
FLG15_18275	COG2202	Pas domain
FLG15_18275	COG2205	protein histidine kinase activity
FLG15_18295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FLG15_18300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FLG15_18305	COG1522	sequence-specific DNA binding
FLG15_18370	COG0842	Transport permease protein
FLG15_18375	COG1131	(ABC) transporter
FLG15_18390	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FLG15_18395	COG1573	uracil-dna glycosylase
FLG15_18405	COG3384	dioxygenase
FLG15_18415	COG0583	DNA-binding transcription factor activity
FLG15_18425	COG0667	Aldo Keto reductase
FLG15_18440	COG3590	peptidase
FLG15_18465	COG0531	amino acid
FLG15_18500	COG3685	Protein conserved in bacteria
FLG15_18505	COG3546	catalase activity
FLG15_18555	COG1271	oxidase subunit
FLG15_18560	COG1294	oxidase, subunit
FLG15_18575	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_18580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FLG15_18600	COG1132	(ABC) transporter
FLG15_18615	COG1063	alcohol dehydrogenase
FLG15_18690	COG0251	oxidation-reduction process
FLG15_18715	COG0659	secondary active sulfate transmembrane transporter activity
FLG15_18720	COG0038	chloride channel
FLG15_18730	COG0024	Methionine aminopeptidase
FLG15_18745	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_18765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FLG15_18770	COG1490	D-aminoacyl-tRNA deacylase activity
FLG15_18775	COG1560	Kdo2-lipid A biosynthetic process
FLG15_18820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FLG15_18820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FLG15_18825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FLG15_18830	COG0242	peptide deformylase activity
FLG15_18835	COG1652	LysM domain
FLG15_18840	COG0758	DNA mediated transformation
FLG15_18860	COG1754	DNA topoisomerase type I activity
FLG15_18860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FLG15_18865	COG0009	L-threonylcarbamoyladenylate synthase
FLG15_18880	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_18890	COG0616	signal peptide processing
FLG15_18895	COG0534	Mate efflux family protein
FLG15_18915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FLG15_18920	COG0625	glutathione transferase activity
FLG15_18935	COG1252	NADH dehydrogenase
FLG15_18940	COG2860	membrane
FLG15_18945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FLG15_18950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FLG15_18955	COG3437	response regulator, receiver
FLG15_18960	COG2177	Part of the ABC transporter FtsEX involved in
FLG15_18965	COG2884	Cell division ATP-binding protein ftsE
FLG15_18975	COG3118	belongs to the thioredoxin family
FLG15_18980	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FLG15_18990	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FLG15_18995	COG0583	DNA-binding transcription factor activity
FLG15_19015	COG1652	LysM domain
FLG15_19020	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FLG15_19020	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FLG15_19025	COG1473	amidohydrolase
FLG15_19030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FLG15_19035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FLG15_19045	COG5383	Protein conserved in bacteria
FLG15_19095	COG4948	Mandelate Racemase Muconate Lactonizing
FLG15_19105	COG0531	amino acid
FLG15_19125	COG2133	pyrroloquinoline quinone binding
FLG15_19135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FLG15_19140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FLG15_19150	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FLG15_19155	COG1610	YqeY-like protein
FLG15_19165	COG1295	ribonuclease BN
FLG15_19170	COG0358	DNA primase activity
FLG15_19185	COG0109	protoheme IX farnesyltransferase activity
FLG15_19215	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FLG15_19230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FLG15_19270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FLG15_19275	COG0739	heme binding
FLG15_19280	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FLG15_19290	COG2211	Major facilitator Superfamily
FLG15_19295	COG0708	Exodeoxyribonuclease III
FLG15_19300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FLG15_19310	COG1192	Involved in chromosome partitioning
FLG15_19315	COG1475	DNA binding
FLG15_19330	COG0463	Glycosyl transferase, family 2
FLG15_19350	COG0756	dUTP diphosphatase activity
FLG15_19355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FLG15_19360	COG2003	Belongs to the UPF0758 family
FLG15_19365	COG0018	arginyl-trna synthetase
FLG15_19380	COG4221	oxidoreductase activity
FLG15_19385	COG2755	lipolytic protein G-D-S-L family
FLG15_19385	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FLG15_19405	COG1166	arginine decarboxylase activity
FLG15_19410	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FLG15_19430	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FLG15_19430	COG3291	Pkd domain containing protein
FLG15_19470	COG1104	cysteine desulfurase activity
FLG15_19515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FLG15_19540	COG4644	lycopene metabolic process
FLG15_19545	COG2951	lytic endotransglycosylase activity
FLG15_19610	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FLG15_19645	COG1690	Belongs to the RtcB family
FLG15_19680	COG1090	epimerase
FLG15_19685	COG0745	RESPONSE REGULATOR receiver
FLG15_19690	COG0642	Histidine kinase
FLG15_19710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FLG15_19735	COG1011	Hydrolase
FLG15_19740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FLG15_19755	COG0753	catalase activity
FLG15_19770	COG2197	response regulator
FLG15_19775	COG4585	Histidine kinase
FLG15_19780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FLG15_19785	COG1136	(ABC) transporter
FLG15_19805	COG2962	Rard protein
FLG15_19810	COG0697	spore germination
FLG15_19835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FLG15_19840	COG0180	Tryptophanyl-tRNA synthetase
FLG15_19845	COG3237	CsbD-like
FLG15_19890	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FLG15_19905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FLG15_19910	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FLG15_19910	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FLG15_19925	COG3228	Belongs to the MtfA family
FLG15_19940	COG2205	protein histidine kinase activity
FLG15_19945	COG0745	RESPONSE REGULATOR receiver
FLG15_19955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FLG15_20000	COG1199	ATP-dependent helicase activity
FLG15_20015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FLG15_20115	COG0625	glutathione transferase activity
FLG15_20155	COG4555	ABC transporter
FLG15_20165	COG1476	TRANSCRIPTIONal
FLG15_20185	COG1230	cation diffusion facilitator family transporter
FLG15_20190	COG0633	Ferredoxin
FLG15_20190	COG0543	2 iron, 2 sulfur cluster binding
FLG15_20195	COG1131	(ABC) transporter
FLG15_20200	COG0842	Transport permease protein
FLG15_20215	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FLG15_20245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FLG15_20260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FLG15_20265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FLG15_20280	COG1042	CoA-binding domain protein
FLG15_20280	COG0045	succinate-CoA ligase (ADP-forming) activity
FLG15_20280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FLG15_20285	COG2239	Acts as a magnesium transporter
FLG15_20305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FLG15_20310	COG3387	PFAM Glycoside hydrolase 15-related
FLG15_20320	COG3100	YcgL domain-containing protein
FLG15_20325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FLG15_20335	COG0463	Glycosyl transferase, family 2
FLG15_20345	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_20390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FLG15_20405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FLG15_20465	COG0408	coproporphyrinogen oxidase activity
FLG15_20510	COG0515	serine threonine protein kinase
FLG15_20510	COG2815	serine threonine protein kinase
FLG15_20515	COG0631	protein serine/threonine phosphatase activity
FLG15_20540	COG0667	Aldo Keto reductase
FLG15_20545	COG0583	DNA-binding transcription factor activity
FLG15_20560	COG3501	Rhs element vgr protein
FLG15_20620	COG0154	amidase activity
FLG15_20650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FLG15_20680	COG3135	benzoate transporter
FLG15_20710	COG0676	glucose-6-phosphate 1-epimerase activity
FLG15_20725	COG0730	response to heat
FLG15_20745	COG0302	gtp cyclohydrolase
FLG15_20760	COG1566	PFAM secretion protein HlyD family protein
FLG15_20770	COG1289	transmembrane transporter activity
FLG15_20775	COG0477	Major facilitator Superfamily
FLG15_20785	COG0583	DNA-binding transcription factor activity
FLG15_20790	COG4221	oxidoreductase activity
FLG15_20800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FLG15_20845	COG0564	pseudouridine synthase activity
FLG15_20870	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FLG15_20880	COG1435	thymidine kinase activity
FLG15_20885	COG0210	DNA helicase
FLG15_20935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FLG15_20945	COG3132	Protein of unknown function, DUF480
FLG15_20950	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FLG15_20955	COG0284	orotidine-5'-phosphate decarboxylase activity
FLG15_21000	COG2937	Belongs to the GPAT DAPAT family
FLG15_21070	COG2211	Major facilitator Superfamily
FLG15_21085	COG3693	PFAM glycoside hydrolase, family 10
FLG15_21095	COG3693	PFAM glycoside hydrolase, family 10
FLG15_21100	COG1904	glucuronate isomerase
FLG15_21105	COG3250	beta-galactosidase activity
FLG15_21115	COG3386	PFAM SMP-30 Gluconolaconase
FLG15_21135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FLG15_21195	COG0246	Mannitol dehydrogenase
FLG15_21200	COG1472	Belongs to the glycosyl hydrolase 3 family
FLG15_21210	COG4948	Mandelate Racemase Muconate Lactonizing
FLG15_21220	COG3661	Belongs to the glycosyl hydrolase 67 family
FLG15_21230	COG2115	Belongs to the xylose isomerase family
FLG15_21240	COG0037	tRNA processing
FLG15_21245	COG2974	May be involved in recombination
FLG15_21265	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FLG15_21275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FLG15_21280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FLG15_21285	COG0805	protein transport
FLG15_21305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FLG15_21305	COG0519	Catalyzes the synthesis of GMP from XMP
FLG15_21320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FLG15_21325	COG0752	glycyl-tRNA synthetase alpha subunit
FLG15_21335	COG0457	Tetratricopeptide repeat
FLG15_21345	COG0729	surface antigen
FLG15_21350	COG2911	Protein conserved in bacteria
FLG15_21380	COG3265	gluconokinase activity
FLG15_21385	COG2211	Major facilitator Superfamily
FLG15_21390	COG3459	Glycosyltransferase 36 associated
FLG15_21405	COG2205	protein histidine kinase activity
FLG15_21410	COG1971	Probably functions as a manganese efflux pump
FLG15_21420	COG2207	Transcriptional regulator
FLG15_21420	COG1917	Cupin 2, conserved barrel domain protein
FLG15_21425	COG1414	Transcriptional regulator
FLG15_21435	COG3254	rhamnose metabolic process
FLG15_21440	COG4948	Mandelate Racemase Muconate Lactonizing
FLG15_21445	COG0179	Fumarylacetoacetate (FAA) hydrolase
FLG15_21450	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_21470	COG3507	Belongs to the glycosyl hydrolase 43 family
FLG15_21505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FLG15_21515	COG3162	membrane
FLG15_21520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FLG15_21530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FLG15_21540	COG1846	Transcriptional regulator
FLG15_21540	COG1940	carbohydrate kinase activity
FLG15_21545	COG0708	Exodeoxyribonuclease III
FLG15_21560	COG2091	lysine biosynthetic process via aminoadipic acid
FLG15_21585	COG3540	Alkaline phosphatase
FLG15_21590	COG0357	Ribosomal RNA small subunit methyltransferase G
FLG15_21610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FLG15_21630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FLG15_21635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FLG15_21640	COG2159	amidohydrolase
FLG15_21655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FLG15_21660	COG0583	DNA-binding transcription factor activity
FLG15_21665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FLG15_21680	COG0210	DNA helicase
FLG15_21765	COG0439	Biotin carboxylase
FLG15_21795	COG4974	Belongs to the 'phage' integrase family
FLG15_21830	COG0793	Belongs to the peptidase S41A family
FLG15_21835	COG4942	peptidase
FLG15_21845	COG2234	aminopeptidase activity
FLG15_21855	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FLG15_21860	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FLG15_21870	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FLG15_21880	COG1064	alcohol dehydrogenase
FLG15_21895	COG0493	'glutamate synthase
FLG15_21900	COG0067	glutamate synthase
FLG15_21900	COG0069	glutamate synthase activity
FLG15_21900	COG0070	glutamate synthase
FLG15_21990	COG1111	helicase
FLG15_21990	COG1205	dead DEAH box helicase
FLG15_21995	COG1272	protein, Hemolysin III
FLG15_22015	COG0300	oxidoreductase activity
FLG15_22020	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_22040	COG2249	NAD(P)H dehydrogenase (quinone) activity
FLG15_22070	COG0584	glycerophosphoryl diester phosphodiesterase
FLG15_22080	COG1940	carbohydrate kinase activity
FLG15_22095	COG5002	protein histidine kinase activity
FLG15_22100	COG0745	RESPONSE REGULATOR receiver
FLG15_22110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FLG15_22190	COG2194	sulfuric ester hydrolase activity
FLG15_22255	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FLG15_22290	COG0501	Belongs to the peptidase M48B family
FLG15_22300	COG0187	DNA topoisomerase II activity
FLG15_22305	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FLG15_22325	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FLG15_22330	COG0594	ribonuclease P activity
FLG15_22335	COG0706	membrane insertase activity
FLG15_22340	COG0726	polysaccharide deacetylase
FLG15_22345	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FLG15_22360	COG0584	glycerophosphoryl diester phosphodiesterase
FLG15_22375	COG0861	Integral membrane protein TerC family
FLG15_22385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FLG15_22400	COG2271	Major facilitator Superfamily
FLG15_22405	COG1929	Belongs to the glycerate kinase type-1 family
FLG15_22410	COG3835	regulator
FLG15_22415	COG2199	diguanylate cyclase activity
FLG15_22415	COG2203	Gaf domain
FLG15_22430	COG3537	Alpha-1,2-mannosidase
FLG15_22435	COG0531	amino acid
FLG15_22455	COG0583	DNA-binding transcription factor activity
FLG15_22465	COG1322	Protein conserved in bacteria
FLG15_22475	COG0386	Belongs to the glutathione peroxidase family
FLG15_22485	COG2853	Lipoprotein
FLG15_22500	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FLG15_22505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FLG15_22510	COG1127	ABC transporter
FLG15_22545	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FLG15_22550	COG1074	ATP-dependent DNA helicase activity
FLG15_22555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FLG15_22555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FLG15_22620	COG1028	Short-chain dehydrogenase reductase Sdr
FLG15_22700	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FLG15_22705	COG3710	Transcriptional regulator
FLG15_22725	COG2197	response regulator
FLG15_22730	COG4585	Histidine kinase
FLG15_22735	COG1755	Isoprenylcysteine carboxyl methyltransferase
FLG15_22740	COG1304	FMN binding
FLG15_22770	COG4772	TonB-dependent receptor
FLG15_22800	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FLG15_22845	COG0714	Associated with various cellular activities
FLG15_22875	COG3039	Transposase
FLG15_22920	COG2337	Toxic component of a toxin-antitoxin (TA) module
FLG15_23000	COG1487	ribonuclease activity
FLG15_23005	COG4691	Plasmid stability protein
FLG15_23080	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FLG15_23105	COG2205	protein histidine kinase activity
FLG15_23105	COG0784	Response regulator, receiver
FLG15_23110	COG0745	RESPONSE REGULATOR receiver
FLG15_23215	COG0489	protein tyrosine kinase activity
FLG15_23290	COG3039	Transposase
FLG15_23310	COG3039	Transposase