locus-tag	class	description
K9838_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K9838_00020	COG0187	DNA topoisomerase II activity
K9838_00030	COG0501	Belongs to the peptidase M48B family
K9838_00065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K9838_00075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K9838_00120	COG0793	Belongs to the peptidase S41A family
K9838_00125	COG4942	peptidase
K9838_00135	COG2234	aminopeptidase activity
K9838_00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K9838_00150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K9838_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K9838_00165	COG1064	alcohol dehydrogenase
K9838_00180	COG0493	'glutamate synthase
K9838_00185	COG0067	glutamate synthase
K9838_00185	COG0069	glutamate synthase activity
K9838_00185	COG0070	glutamate synthase
K9838_00240	COG3039	Transposase
K9838_00255	COG3039	Transposase
K9838_00295	COG3039	Transposase
K9838_00325	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K9838_00350	COG2197	response regulator
K9838_00355	COG4585	Histidine kinase
K9838_00360	COG1755	Isoprenylcysteine carboxyl methyltransferase
K9838_00365	COG1304	FMN binding
K9838_00390	COG4772	TonB-dependent receptor
K9838_00400	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K9838_00440	COG0714	Associated with various cellular activities
K9838_00490	COG0477	Major facilitator Superfamily
K9838_00495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K9838_00540	COG3237	CsbD-like
K9838_00555	COG2249	NAD(P)H dehydrogenase (quinone) activity
K9838_00585	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_00590	COG0300	oxidoreductase activity
K9838_00610	COG1272	protein, Hemolysin III
K9838_00615	COG1205	dead DEAH box helicase
K9838_00615	COG1111	helicase
K9838_00670	COG3039	Transposase
K9838_00685	COG0366	Alpha amylase catalytic
K9838_00690	COG0366	Alpha amylase catalytic
K9838_00695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K9838_00715	COG2755	lipolytic protein G-D-S-L family
K9838_00715	COG0657	acetylesterase activity
K9838_00725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K9838_00740	COG3507	Belongs to the glycosyl hydrolase 43 family
K9838_00745	COG1609	Transcriptional regulator
K9838_00750	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K9838_00755	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_00770	COG2755	lipolytic protein G-D-S-L family
K9838_00780	COG3186	Phenylalanine-4-hydroxylase
K9838_00785	COG1522	sequence-specific DNA binding
K9838_00795	COG1752	Esterase of the alpha-beta hydrolase superfamily
K9838_00805	COG1119	ATPase activity
K9838_00820	COG0517	IMP dehydrogenase activity
K9838_00820	COG1125	glycine betaine transport
K9838_00835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K9838_00870	COG0489	protein tyrosine kinase activity
K9838_00875	COG2062	phosphohistidine phosphatase, SixA
K9838_00885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K9838_00925	COG1968	undecaprenyl-diphosphatase activity
K9838_00930	COG0174	glutamine synthetase
K9838_00935	COG0347	Belongs to the P(II) protein family
K9838_00940	COG0004	ammonium transporteR
K9838_00945	COG3852	Histidine kinase
K9838_00950	COG2204	response regulator
K9838_00955	COG2032	superoxide dismutase activity
K9838_00960	COG2032	superoxide dismutase activity
K9838_00990	COG0183	Belongs to the thiolase family
K9838_01025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K9838_01030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K9838_01035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K9838_01045	COG0028	Belongs to the TPP enzyme family
K9838_01050	COG2205	protein histidine kinase activity
K9838_01075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K9838_01090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K9838_01095	COG3177	Filamentation induced by cAMP protein fic
K9838_01100	COG0596	Alpha beta hydrolase
K9838_01105	COG0727	PFAM Uncharacterised protein family (UPF0153)
K9838_01110	COG0318	PFAM AMP-dependent synthetase and ligase
K9838_01115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K9838_01140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K9838_01150	COG0564	pseudouridine synthase activity
K9838_01180	COG0339	signal peptide processing
K9838_01215	COG0475	glutathione-regulated potassium exporter activity
K9838_01220	COG0583	DNA-binding transcription factor activity
K9838_01225	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K9838_01230	COG2224	Isocitrate lyase
K9838_01245	COG3039	Transposase
K9838_01270	COG3039	Transposase
K9838_01295	COG3039	Transposase
K9838_01310	COG4770	biotin carboxylase activity
K9838_01315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K9838_01320	COG1960	acyl-CoA dehydrogenase activity
K9838_01390	COG0697	spore germination
K9838_01400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K9838_01405	COG1846	Transcriptional regulator
K9838_01410	COG1764	response to oxidative stress
K9838_01440	COG2130	NADP-dependent
K9838_01455	COG1187	pseudouridine synthase activity
K9838_01465	COG1643	Atp-dependent helicase
K9838_01470	COG4807	Protein conserved in bacteria
K9838_01480	COG2072	flavoprotein involved in K transport
K9838_01500	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K9838_01510	COG0583	DNA-binding transcription factor activity
K9838_01550	COG2252	PERMEase
K9838_01570	COG0084	hydrolase, TatD family'
K9838_01585	COG0583	DNA-binding transcription factor activity
K9838_01610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K9838_01615	COG1902	pentaerythritol trinitrate reductase activity
K9838_01635	COG0745	RESPONSE REGULATOR receiver
K9838_01640	COG2205	protein histidine kinase activity
K9838_01645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9838_01675	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K9838_01680	COG0583	DNA-binding transcription factor activity
K9838_01715	COG0702	epimerase
K9838_01720	COG1733	regulation of RNA biosynthetic process
K9838_01760	COG0129	dihydroxy-acid dehydratase activity
K9838_01775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K9838_01835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K9838_01860	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K9838_01875	COG3485	protocatechuate 3,4-dioxygenase
K9838_01880	COG3485	protocatechuate 3,4-dioxygenase
K9838_01890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K9838_01895	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K9838_01905	COG1414	Transcriptional regulator
K9838_01915	COG0657	acetylesterase activity
K9838_01925	COG0445	tRNA wobble uridine modification
K9838_01935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K9838_01965	COG2267	carboxylic ester hydrolase activity
K9838_01975	COG0156	8-amino-7-oxononanoate synthase activity
K9838_01980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K9838_01990	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K9838_02075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K9838_02145	COG3264	Mechanosensitive ion channel
K9838_02145	COG1511	domain protein
K9838_02150	COG1368	sulfuric ester hydrolase activity
K9838_02155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K9838_02160	COG2354	Protein conserved in bacteria
K9838_02170	COG0297	glycogen (starch) synthase activity
K9838_02175	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K9838_02180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K9838_02205	COG0702	epimerase
K9838_02210	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_02245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K9838_02250	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_02260	COG0513	Belongs to the DEAD box helicase family
K9838_02265	COG0508	dehydrogenase complex catalyzes the overall conversion of
K9838_02280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K9838_02290	COG3483	tryptophan 2,3-dioxygenase activity
K9838_02295	COG3104	oligopeptide transport
K9838_02315	COG2852	Protein conserved in bacteria
K9838_02320	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K9838_02340	COG1320	monovalent cation:proton antiporter activity
K9838_02345	COG2212	antiporter activity
K9838_02355	COG0651	ATP synthesis coupled electron transport
K9838_02360	COG1006	Multisubunit Na H antiporter MnhC subunit
K9838_02365	COG2111	Na H antiporter
K9838_02365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K9838_02380	COG3179	chitinase
K9838_02400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K9838_02405	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K9838_02415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K9838_02425	COG1597	lipid kinase activity
K9838_02455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K9838_02460	COG0134	indole-3-glycerol-phosphate synthase activity
K9838_02470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K9838_02475	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K9838_02485	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
K9838_02495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K9838_02510	COG1051	belongs to the nudix hydrolase family
K9838_02560	COG0316	Belongs to the HesB IscA family
K9838_02575	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K9838_02590	COG2814	Major facilitator Superfamily
K9838_02600	COG2814	Major facilitator Superfamily
K9838_02605	COG1289	transmembrane transporter activity
K9838_02615	COG0151	Belongs to the GarS family
K9838_02625	COG0138	bifunctional purine biosynthesis protein purh
K9838_02630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K9838_02640	COG0671	phosphoesterase, PA-phosphatase related
K9838_02640	COG2453	phosphatase
K9838_02680	COG4589	Belongs to the CDS family
K9838_02685	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K9838_02705	COG2264	protein methyltransferase activity
K9838_02720	COG0439	Biotin carboxylase
K9838_02730	COG0511	ligase activity, forming carbon-carbon bonds
K9838_02735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K9838_02745	COG1324	tolerance protein
K9838_02755	COG2356	endonuclease I
K9838_02765	COG0459	protein refolding
K9838_02780	COG3550	peptidyl-serine autophosphorylation
K9838_02785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K9838_02800	COG3386	PFAM SMP-30 Gluconolaconase
K9838_02810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K9838_02815	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K9838_02840	COG0778	Nitroreductase
K9838_02845	COG2353	YceI-like domain
K9838_02880	COG3052	prosthetic group binding
K9838_02905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K9838_02915	COG1802	Transcriptional regulator
K9838_02970	COG3039	Transposase
K9838_02990	COG3039	Transposase
K9838_03000	COG3039	Transposase
K9838_03010	COG4221	oxidoreductase activity
K9838_03040	COG4221	oxidoreductase activity
K9838_03050	COG0435	Glutathione S-transferase
K9838_03080	COG2409	Drug exporters of the RND superfamily
K9838_03110	COG1959	2 iron, 2 sulfur cluster binding
K9838_03135	COG0697	spore germination
K9838_03140	COG4305	rare lipoprotein A
K9838_03145	COG5297	Belongs to the glycosyl hydrolase family 6
K9838_03155	COG1113	amino acid transport
K9838_03165	COG0598	Magnesium transport protein CorA
K9838_03180	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
K9838_03220	COG0840	transmembrane signaling receptor activity
K9838_03225	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K9838_03225	COG5297	Belongs to the glycosyl hydrolase family 6
K9838_03245	COG3039	Transposase
K9838_03250	COG2943	transferase activity, transferring hexosyl groups
K9838_03260	COG3275	phosphorelay sensor kinase activity
K9838_03270	COG0181	hydroxymethylbilane synthase activity
K9838_03305	COG1505	serine-type exopeptidase activity
K9838_03315	COG0436	Aminotransferase
K9838_03325	COG2832	Protein of unknown function (DUF454)
K9838_03335	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K9838_03345	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K9838_03350	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K9838_03355	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K9838_03380	COG2226	methyltransferase
K9838_03385	COG3300	MHYT domain
K9838_03385	COG5001	Diguanylate cyclase
K9838_03390	COG0308	aminopeptidase N
K9838_03415	COG2010	Cytochrome c
K9838_03450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K9838_03455	COG1077	Cell shape determining protein MreB Mrl
K9838_03460	COG1792	Involved in formation and maintenance of cell shape
K9838_03475	COG0772	Belongs to the SEDS family
K9838_03495	COG3039	Transposase
K9838_03525	COG2951	lytic endotransglycosylase activity
K9838_03530	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K9838_03535	COG1686	Belongs to the peptidase S11 family
K9838_03545	COG2921	Belongs to the UPF0250 family
K9838_03550	COG0321	lipoyl(octanoyl) transferase activity
K9838_03555	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K9838_03580	COG1051	belongs to the nudix hydrolase family
K9838_03580	COG1056	cytidyltransferase-related domain
K9838_03615	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K9838_03625	COG2823	Periplasmic or secreted lipoprotein
K9838_03630	COG4251	negative regulation of phosphorylation
K9838_03635	COG0784	Response regulator, receiver
K9838_03640	COG4191	Histidine kinase
K9838_03645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K9838_03700	COG1459	type II secretion system
K9838_03720	COG4795	General secretion pathway protein
K9838_03745	COG2188	Transcriptional regulator
K9838_03755	COG1609	Transcriptional regulator
K9838_03760	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K9838_03765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K9838_03775	COG0617	tRNA 3'-terminal CCA addition
K9838_03780	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K9838_03785	COG1012	belongs to the aldehyde dehydrogenase family
K9838_03790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K9838_03800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K9838_03815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K9838_03830	COG2205	protein histidine kinase activity
K9838_03860	COG3791	Glutathione-dependent formaldehyde-activating
K9838_03875	COG0488	(ABC) transporter
K9838_03885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K9838_03890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K9838_03900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K9838_03900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K9838_03920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K9838_03925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K9838_03930	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K9838_03945	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K9838_03950	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K9838_03960	COG2205	protein histidine kinase activity
K9838_03965	COG0745	RESPONSE REGULATOR receiver
K9838_03975	COG0277	FAD linked oxidase domain protein
K9838_03980	COG1988	membrane-bound metal-dependent
K9838_03985	COG0792	nuclease activity
K9838_04015	COG3039	Transposase
K9838_04050	COG3116	cell division
K9838_04060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K9838_04065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K9838_04070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K9838_04080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K9838_04085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K9838_04090	COG1181	Belongs to the D-alanine--D-alanine ligase family
K9838_04095	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K9838_04110	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K9838_04120	COG0739	heme binding
K9838_04125	COG0653	protein targeting
K9838_04130	COG0494	nUDIX hydrolase
K9838_04145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K9838_04155	COG0604	alcohol dehydrogenase
K9838_04155	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_04155	COG3321	synthase
K9838_04170	COG0366	Alpha amylase catalytic
K9838_04200	COG2226	methyltransferase
K9838_04205	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K9838_04215	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K9838_04255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K9838_04265	COG4106	trans-aconitate 2-methyltransferase activity
K9838_04270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K9838_04280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K9838_04285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K9838_04290	COG0667	Aldo Keto reductase
K9838_04300	COG4771	TonB-dependent receptor
K9838_04325	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
K9838_04335	COG2175	clavaminate synthase activity
K9838_04345	COG4181	ATPase activity
K9838_04360	COG0642	Histidine kinase
K9838_04370	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K9838_04380	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K9838_04390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K9838_04395	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K9838_04410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K9838_04415	COG2967	ApaG domain
K9838_04420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K9838_04425	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K9838_04430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K9838_04435	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K9838_04440	COG0123	including yeast histone deacetylase and acetoin utilization protein
K9838_04445	COG2096	Adenosyltransferase
K9838_04455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K9838_04460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K9838_04490	COG3384	dioxygenase
K9838_04495	COG0583	DNA-binding transcription factor activity
K9838_04500	COG0318	PFAM AMP-dependent synthetase and ligase
K9838_04510	COG1024	Enoyl-CoA hydratase
K9838_04540	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
K9838_04560	COG0697	spore germination
K9838_04570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K9838_04595	COG2197	response regulator
K9838_04605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K9838_04620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K9838_04625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K9838_04630	COG0583	DNA-binding transcription factor activity
K9838_04635	COG3634	alkyl hydroperoxide reductase activity
K9838_04645	COG2890	protein-(glutamine-N5) methyltransferase activity
K9838_04665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K9838_04665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K9838_04720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K9838_04725	COG1404	Belongs to the peptidase S8 family
K9838_04730	COG1404	Belongs to the peptidase S8 family
K9838_04735	COG1404	Belongs to the peptidase S8 family
K9838_04740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K9838_04765	COG1295	ribonuclease BN
K9838_04770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K9838_04775	COG1254	Belongs to the acylphosphatase family
K9838_04790	COG0521	Mo-molybdopterin cofactor biosynthetic process
K9838_04800	COG3039	Transposase
K9838_04810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K9838_04815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K9838_04825	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K9838_04830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K9838_04840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K9838_04845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K9838_04850	COG0193	aminoacyl-tRNA hydrolase activity
K9838_04855	COG0012	GTP binding
K9838_04875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K9838_04890	COG0250	Participates in transcription elongation, termination and antitermination
K9838_04895	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K9838_04900	COG0081	regulation of translation
K9838_04905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K9838_04915	COG0085	RNA polymerase activity
K9838_04920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K9838_04925	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K9838_04930	COG0049	tRNA binding
K9838_04935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K9838_04940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K9838_04960	COG0051	transcription antitermination factor activity, RNA binding
K9838_04970	COG0088	Forms part of the polypeptide exit tunnel
K9838_04975	COG0089	rRNA binding
K9838_04980	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K9838_04985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K9838_04995	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K9838_05000	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K9838_05005	COG0255	Belongs to the universal ribosomal protein uL29 family
K9838_05010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K9838_05020	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K9838_05025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K9838_05035	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K9838_05040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K9838_05045	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K9838_05055	COG1841	ribosomal large subunit assembly
K9838_05060	COG0200	Binds to the 23S rRNA
K9838_05065	COG0201	protein transport
K9838_05090	COG0203	ribosomal protein L17
K9838_05095	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K9838_05115	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K9838_05125	COG0154	amidase activity
K9838_05135	COG1217	gtp-binding protein TYPA
K9838_05140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K9838_05145	COG0039	L-malate dehydrogenase activity
K9838_05150	COG0625	glutathione transferase activity
K9838_05165	COG0446	pyridine nucleotide-disulphide oxidoreductase
K9838_05165	COG1902	pentaerythritol trinitrate reductase activity
K9838_05175	COG2885	chlorophyll binding
K9838_05195	COG0156	8-amino-7-oxononanoate synthase activity
K9838_05200	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
K9838_05205	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K9838_05210	COG4208	sulfate ABC transporter
K9838_05215	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K9838_05245	COG0406	alpha-ribazole phosphatase activity
K9838_05255	COG0285	dihydrofolate synthase activity
K9838_05275	COG2833	Protein of unknown function (DUF455)
K9838_05280	COG3291	Pkd domain containing protein
K9838_05290	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K9838_05295	COG0671	phosphoesterase, PA-phosphatase related
K9838_05300	COG0438	transferase activity, transferring glycosyl groups
K9838_05310	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K9838_05325	COG4783	chaperone-mediated protein folding
K9838_05340	COG0473	3-isopropylmalate dehydrogenase activity
K9838_05385	COG0544	peptidyl-prolyl cis-trans isomerase activity
K9838_05395	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K9838_05425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K9838_05435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K9838_05445	COG0328	RNA-DNA hybrid ribonuclease activity
K9838_05450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K9838_05455	COG0631	protein serine/threonine phosphatase activity
K9838_05470	COG0859	PFAM glycosyl transferase family 9
K9838_05475	COG3642	lipopolysaccharide core region biosynthetic process
K9838_05480	COG1234	tRNA 3'-trailer cleavage
K9838_05485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K9838_05495	COG0315	cyclic pyranopterin monophosphate synthase activity
K9838_05500	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K9838_05505	COG0314	molybdopterin synthase activity
K9838_05560	COG2003	Belongs to the UPF0758 family
K9838_05645	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K9838_05650	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K9838_05655	COG0537	adenosine 5'-monophosphoramidase activity
K9838_05675	COG0714	Associated with various cellular activities
K9838_05685	COG0424	maF-like protein
K9838_05690	COG1399	metal-binding, possibly nucleic acid-binding protein
K9838_05695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K9838_05700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K9838_05715	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_05730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K9838_05735	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K9838_05765	COG3829	transcription factor binding
K9838_05810	COG2373	Large extracellular alpha-helical protein
K9838_05830	COG4191	Histidine kinase
K9838_05835	COG4953	penicillin-binding protein 1C
K9838_05845	COG0678	peroxiredoxin activity
K9838_05865	COG0330	HflC and HflK could
K9838_05870	COG0330	HflC and HflK could
K9838_05890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K9838_05910	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_05915	COG1309	transcriptional regulator
K9838_05950	COG3039	Transposase
K9838_05995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K9838_06005	COG3387	PFAM Glycoside hydrolase 15-related
K9838_06010	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_06060	COG3039	Transposase
K9838_06070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K9838_06075	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K9838_06080	COG2080	2 iron, 2 sulfur cluster binding
K9838_06115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K9838_06130	COG0587	DNA-directed DNA polymerase activity
K9838_06150	COG1297	OPT oligopeptide transporter protein
K9838_06165	COG0823	Involved in the tonB-independent uptake of proteins
K9838_06165	COG1506	peptidase
K9838_06180	COG1917	Cupin 2, conserved barrel domain protein
K9838_06180	COG2207	Transcriptional regulator
K9838_06195	COG3039	Transposase
K9838_06235	COG0753	catalase activity
K9838_06240	COG0656	L-ascorbic acid biosynthetic process
K9838_06250	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K9838_06250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K9838_06275	COG2814	Major facilitator Superfamily
K9838_06320	COG3039	Transposase
K9838_06330	COG3039	Transposase
K9838_06340	COG2194	sulfuric ester hydrolase activity
K9838_06355	COG0745	RESPONSE REGULATOR receiver
K9838_06360	COG0642	Histidine kinase
K9838_06370	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K9838_06375	COG2894	cell division
K9838_06380	COG0850	regulation of cytokinetic process
K9838_06390	COG4585	Histidine kinase
K9838_06395	COG2197	response regulator
K9838_06410	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K9838_06435	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K9838_06445	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K9838_06460	COG1595	DNA-templated transcription, initiation
K9838_06470	COG1946	Acyl-CoA thioesterase
K9838_06485	COG0824	Thioesterase
K9838_06490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K9838_06495	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K9838_06500	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K9838_06505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K9838_06510	COG0268	Binds directly to 16S ribosomal RNA
K9838_06515	COG0728	peptidoglycan biosynthetic process
K9838_06520	COG0196	riboflavin kinase activity
K9838_06525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K9838_06530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K9838_06535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K9838_06550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K9838_06555	COG1845	cytochrome c oxidase, subunit III
K9838_06560	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K9838_06575	COG3152	Membrane
K9838_06585	COG2207	Transcriptional regulator
K9838_06590	COG0326	Molecular chaperone. Has ATPase activity
K9838_06605	COG1366	Belongs to the anti-sigma-factor antagonist family
K9838_06610	COG2172	sigma factor antagonist activity
K9838_06620	COG2205	protein histidine kinase activity
K9838_06635	COG4771	TonB-dependent receptor
K9838_06645	COG5507	3-demethylubiquinone-9 3-methyltransferase
K9838_06650	COG2205	protein histidine kinase activity
K9838_06660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K9838_06665	COG4999	Histidine kinase
K9838_06665	COG2205	protein histidine kinase activity
K9838_06665	COG3437	response regulator, receiver
K9838_06665	COG3850	Histidine kinase
K9838_06670	COG0784	Response regulator, receiver
K9838_06670	COG4191	Histidine kinase
K9838_06695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K9838_06710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K9838_06715	COG0228	four-way junction DNA binding
K9838_06720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K9838_06725	COG0336	Belongs to the RNA methyltransferase TrmD family
K9838_06730	COG0335	large ribosomal subunit rRNA binding
K9838_06735	COG0534	Mate efflux family protein
K9838_06760	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K9838_06775	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K9838_06780	COG3039	Transposase
K9838_06815	COG0840	transmembrane signaling receptor activity
K9838_06830	COG3250	beta-galactosidase activity
K9838_06835	COG3867	Arabinogalactan endo-beta-1,4-galactanase
K9838_06855	COG1960	acyl-CoA dehydrogenase activity
K9838_06885	COG0457	Tetratricopeptide repeat
K9838_06895	COG0457	Tetratricopeptide repeat
K9838_06920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K9838_06925	COG0481	GTPase activity
K9838_06940	COG0571	ribonuclease III activity
K9838_06945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K9838_06950	COG1381	Involved in DNA repair and RecF pathway recombination
K9838_06960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K9838_06965	COG3039	Transposase
K9838_06970	COG2954	triphosphatase activity
K9838_06975	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K9838_06980	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
K9838_06985	COG3046	protein related to deoxyribodipyrimidine photolyase
K9838_06990	COG1472	Belongs to the glycosyl hydrolase 3 family
K9838_06995	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K9838_07000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K9838_07005	COG1278	Cold shock
K9838_07010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K9838_07020	COG1201	RNA secondary structure unwinding
K9838_07025	COG1793	dna ligase
K9838_07035	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K9838_07035	COG1793	dna ligase
K9838_07070	COG0183	Belongs to the thiolase family
K9838_07090	COG1451	nucleotide metabolic process
K9838_07095	COG5487	UPF0391 membrane protein
K9838_07105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K9838_07120	COG1077	Cell shape determining protein MreB Mrl
K9838_07125	COG1047	Peptidyl-prolyl cis-trans
K9838_07135	COG2824	Alkylphosphonate utilization operon protein PhnA
K9838_07145	COG1902	pentaerythritol trinitrate reductase activity
K9838_07150	COG2814	Major facilitator Superfamily
K9838_07185	COG0392	lysyltransferase activity
K9838_07185	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K9838_07195	COG0251	oxidation-reduction process
K9838_07200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K9838_07215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K9838_07240	COG1595	DNA-templated transcription, initiation
K9838_07255	COG2878	Part of a membrane complex involved in electron transport
K9838_07265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K9838_07265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K9838_07285	COG0346	lactoylglutathione lyase activity
K9838_07300	COG0833	amino acid
K9838_07305	COG2040	homocysteine
K9838_07315	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K9838_07335	COG1695	Transcriptional regulator
K9838_07355	COG1981	membrane
K9838_07370	COG0825	malonyl-CoA metabolic process
K9838_07380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K9838_07385	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K9838_07390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K9838_07395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K9838_07400	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K9838_07410	COG0750	zinc metalloprotease
K9838_07415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K9838_07420	COG0575	Belongs to the CDS family
K9838_07425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K9838_07430	COG0233	cytoplasmic translational termination
K9838_07435	COG0528	UMP kinase activity
K9838_07445	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K9838_07450	COG0052	Belongs to the universal ribosomal protein uS2 family
K9838_07500	COG1393	Belongs to the ArsC family
K9838_07505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K9838_07515	COG0367	asparagine synthase
K9838_07525	COG4774	siderophore transport
K9838_07565	COG1566	PFAM secretion protein HlyD family protein
K9838_07570	COG2814	Major facilitator Superfamily
K9838_07630	COG0339	signal peptide processing
K9838_07635	COG0386	Belongs to the glutathione peroxidase family
K9838_07695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K9838_07700	COG0084	hydrolase, TatD family'
K9838_07715	COG1960	acyl-CoA dehydrogenase activity
K9838_07730	COG0367	asparagine synthase
K9838_07740	COG0305	Participates in initiation and elongation during chromosome replication
K9838_07745	COG0415	Belongs to the DNA photolyase family
K9838_07760	COG0583	DNA-binding transcription factor activity
K9838_07805	COG3706	GGDEF domain
K9838_07880	COG1404	Belongs to the peptidase S8 family
K9838_07885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K9838_07900	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K9838_07910	COG0497	DNA recombination
K9838_07915	COG1420	regulation of RNA biosynthetic process
K9838_07920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K9838_07925	COG0443	Heat shock 70 kDa protein
K9838_07930	COG0484	heat shock protein binding
K9838_07935	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K9838_07965	COG0583	DNA-binding transcription factor activity
K9838_07970	COG1132	(ABC) transporter
K9838_08005	COG2850	peptidyl-arginine hydroxylation
K9838_08030	COG1253	flavin adenine dinucleotide binding
K9838_08055	COG1131	(ABC) transporter
K9838_08060	COG1725	Transcriptional regulator
K9838_08070	COG0386	Belongs to the glutathione peroxidase family
K9838_08095	COG2900	Belongs to the SlyX family
K9838_08125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K9838_08135	COG1410	methionine synthase
K9838_08135	COG0646	methionine synthase
K9838_08140	COG0646	methionine synthase
K9838_08140	COG1410	methionine synthase
K9838_08145	COG2226	methyltransferase
K9838_08150	COG1960	acyl-CoA dehydrogenase activity
K9838_08155	COG1960	acyl-CoA dehydrogenase activity
K9838_08160	COG1960	acyl-CoA dehydrogenase activity
K9838_08165	COG1960	acyl-CoA dehydrogenase activity
K9838_08170	COG1960	acyl-CoA dehydrogenase activity
K9838_08185	COG0557	exoribonuclease II activity
K9838_08195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K9838_08205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K9838_08220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K9838_08225	COG0581	inorganic phosphate transmembrane transporter activity
K9838_08230	COG0573	inorganic phosphate transmembrane transporter activity
K9838_08235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K9838_08260	COG0659	secondary active sulfate transmembrane transporter activity
K9838_08265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K9838_08275	COG1024	Enoyl-CoA hydratase
K9838_08285	COG0494	nUDIX hydrolase
K9838_08320	COG0488	(ABC) transporter
K9838_08330	COG0116	Belongs to the methyltransferase superfamily
K9838_08330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K9838_08335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K9838_08350	COG0667	Aldo Keto reductase
K9838_08360	COG2925	Exonuclease
K9838_08370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K9838_08375	COG3844	kynureninase activity
K9838_08385	COG0662	Cupin 2, conserved barrel domain protein
K9838_08390	COG0288	reversible hydration of carbon dioxide
K9838_08480	COG0017	Asparaginyl-tRNA synthetase
K9838_08485	COG0316	Belongs to the HesB IscA family
K9838_08490	COG0360	Binds together with S18 to 16S ribosomal RNA
K9838_08495	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K9838_08500	COG0359	binds to the 23S rRNA
K9838_08510	COG3115	cell septum assembly
K9838_08520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K9838_08525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K9838_08530	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K9838_08540	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K9838_08560	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K9838_08570	COG2986	histidine ammonia-lyase
K9838_08575	COG1228	amidohydrolase
K9838_08620	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K9838_08625	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K9838_08630	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K9838_08635	COG0077	Prephenate dehydratase
K9838_08635	COG1605	Chorismate mutase
K9838_08640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K9838_08655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K9838_08660	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K9838_08665	COG0583	DNA-binding transcription factor activity
K9838_08685	COG0840	transmembrane signaling receptor activity
K9838_08705	COG4191	Histidine kinase
K9838_08705	COG0784	Response regulator, receiver
K9838_08710	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
K9838_08730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K9838_08740	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K9838_08750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K9838_08765	COG1595	DNA-templated transcription, initiation
K9838_08815	COG2244	polysaccharide biosynthetic process
K9838_08845	COG2264	protein methyltransferase activity
K9838_08855	COG0438	transferase activity, transferring glycosyl groups
K9838_08870	COG1136	(ABC) transporter
K9838_08880	COG0477	Major facilitator Superfamily
K9838_08885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K9838_08900	COG1253	flavin adenine dinucleotide binding
K9838_08910	COG0306	phosphate transporter
K9838_08935	COG0504	CTP synthase activity
K9838_08950	COG0148	phosphopyruvate hydratase activity
K9838_08955	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K9838_08965	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K9838_08970	COG0585	pseudouridine synthase activity
K9838_08975	COG2840	Smr protein MutS2
K9838_08980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K9838_08985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K9838_08990	COG1238	metal cluster binding
K9838_09000	COG3737	Protein of unknown function (DUF498/DUF598)
K9838_09005	COG1534	Rna-binding protein
K9838_09010	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K9838_09020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K9838_09025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K9838_09035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K9838_09040	COG1546	Belongs to the CinA family
K9838_09050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K9838_09055	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K9838_09060	COG2137	regulation of response to DNA damage stimulus
K9838_09065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K9838_09070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K9838_09085	COG1741	Belongs to the pirin family
K9838_09090	COG0583	DNA-binding transcription factor activity
K9838_09115	COG0351	phosphomethylpyrimidine kinase
K9838_09130	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K9838_09135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K9838_09150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K9838_09160	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K9838_09165	COG3734	2-keto-3-deoxy-galactonokinase
K9838_09175	COG4948	Mandelate Racemase Muconate Lactonizing
K9838_09180	COG0800	Aldolase
K9838_09215	COG1501	Belongs to the glycosyl hydrolase 31 family
K9838_09225	COG1070	Carbohydrate kinase
K9838_09230	COG2115	Belongs to the xylose isomerase family
K9838_09235	COG0477	Major facilitator Superfamily
K9838_09240	COG3039	Transposase
K9838_09255	COG0860	N-Acetylmuramoyl-L-alanine amidase
K9838_09260	COG1469	GTP cyclohydrolase I activity
K9838_09285	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K9838_09290	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K9838_09295	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K9838_09300	COG0166	Belongs to the GPI family
K9838_09320	COG1472	Belongs to the glycosyl hydrolase 3 family
K9838_09330	COG5001	Diguanylate cyclase
K9838_09330	COG2203	Gaf domain
K9838_09330	COG3706	GGDEF domain
K9838_09330	COG4251	negative regulation of phosphorylation
K9838_09335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K9838_09340	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K9838_09350	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K9838_09355	COG0671	phosphoesterase, PA-phosphatase related
K9838_09365	COG1794	racemase activity, acting on amino acids and derivatives
K9838_09370	COG0697	spore germination
K9838_09375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K9838_09380	COG0167	dihydroorotate dehydrogenase activity
K9838_09395	COG1012	belongs to the aldehyde dehydrogenase family
K9838_09435	COG3210	domain, Protein
K9838_09440	COG3039	Transposase
K9838_09460	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
K9838_09465	COG0527	aspartate kinase activity
K9838_09465	COG0460	homoserine dehydrogenase
K9838_09505	COG0124	histidyl-tRNA synthetase
K9838_09515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K9838_09520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K9838_09525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K9838_09530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K9838_09530	COG0131	Imidazoleglycerol-phosphate dehydratase
K9838_09535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K9838_09540	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K9838_09545	COG0107	imidazoleglycerol-phosphate synthase activity
K9838_09550	COG0140	phosphoribosyl-ATP diphosphatase activity
K9838_09550	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K9838_09565	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
K9838_09570	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K9838_09575	COG0235	Class ii aldolase
K9838_09580	COG0531	amino acid
K9838_09585	COG0531	amino acid
K9838_09595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K9838_09600	COG0277	FAD linked oxidase domain protein
K9838_09620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K9838_09665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K9838_09670	COG2258	MOSC domain
K9838_09675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K9838_09680	COG0505	Belongs to the CarA family
K9838_09690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K9838_09695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K9838_09705	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K9838_09715	COG3279	Response regulator of the LytR AlgR family
K9838_09725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K9838_09735	COG2198	Histidine kinase
K9838_09735	COG0784	Response regulator, receiver
K9838_09735	COG2205	protein histidine kinase activity
K9838_09740	COG2198	Histidine kinase
K9838_09740	COG0784	Response regulator, receiver
K9838_09740	COG2205	protein histidine kinase activity
K9838_09745	COG1024	Enoyl-CoA hydratase
K9838_09750	COG0318	PFAM AMP-dependent synthetase and ligase
K9838_09785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K9838_09795	COG2201	protein-glutamate methylesterase activity
K9838_09800	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K9838_09810	COG0840	transmembrane signaling receptor activity
K9838_09820	COG0835	chemotaxis
K9838_09830	COG0840	transmembrane signaling receptor activity
K9838_09835	COG0840	transmembrane signaling receptor activity
K9838_09840	COG0840	transmembrane signaling receptor activity
K9838_09845	COG0840	transmembrane signaling receptor activity
K9838_09850	COG0840	transmembrane signaling receptor activity
K9838_09860	COG0840	transmembrane signaling receptor activity
K9838_09865	COG0840	transmembrane signaling receptor activity
K9838_09875	COG0840	transmembrane signaling receptor activity
K9838_09880	COG0840	transmembrane signaling receptor activity
K9838_09890	COG0840	transmembrane signaling receptor activity
K9838_09915	COG0745	RESPONSE REGULATOR receiver
K9838_09925	COG0835	chemotaxis
K9838_09930	COG1192	Involved in chromosome partitioning
K9838_09935	COG1360	Flagellar Motor Protein
K9838_09940	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K9838_09950	COG1192	Involved in chromosome partitioning
K9838_09955	COG3039	Transposase
K9838_09970	COG3039	Transposase
K9838_09975	COG0643	Histidine kinase
K9838_09975	COG0784	Response regulator, receiver
K9838_09975	COG2198	Histidine kinase
K9838_10005	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K9838_10035	COG1684	flagellar biosynthetic protein fliR
K9838_10060	COG3190	flagellar
K9838_10110	COG1677	Flagellar hook-basal body complex protein FliE
K9838_10145	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_10150	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_10155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K9838_10175	COG2201	protein-glutamate methylesterase activity
K9838_10185	COG2197	response regulator
K9838_10210	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K9838_10220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K9838_10230	COG1705	Flagellar rod assembly protein muramidase FlgJ
K9838_10230	COG3951	Flagellar rod assembly protein muramidase FlgJ
K9838_10235	COG1706	bacterial-type flagellum-dependent cell motility
K9838_10240	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K9838_10250	COG4787	bacterial-type flagellum-dependent cell motility
K9838_10260	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K9838_10265	COG1558	bacterial-type flagellum-dependent cell motility
K9838_10275	COG0835	chemotaxis
K9838_10275	COG0784	Response regulator, receiver
K9838_10300	COG5002	protein histidine kinase activity
K9838_10310	COG4585	Histidine kinase
K9838_10330	COG2915	High frequency lysogenization protein hflD homolog
K9838_10335	COG0482	sulfurtransferase activity
K9838_10350	COG0542	response to heat
K9838_10360	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K9838_10370	COG0492	ferredoxin-NADP+ reductase activity
K9838_10375	COG1674	ftsk spoiiie
K9838_10385	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K9838_10395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K9838_10400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K9838_10405	COG0183	Belongs to the thiolase family
K9838_10410	COG1024	Enoyl-CoA hydratase
K9838_10410	COG1250	3-hydroxyacyl-CoA dehydrogenase
K9838_10425	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K9838_10435	COG1426	Protein conserved in bacteria
K9838_10445	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K9838_10450	COG1160	GTP binding
K9838_10455	COG0303	'Molybdopterin
K9838_10460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K9838_10495	COG0708	Exodeoxyribonuclease III
K9838_10505	COG0303	'Molybdopterin
K9838_10510	COG0746	molybdenum cofactor guanylyltransferase activity
K9838_10530	COG2072	flavoprotein involved in K transport
K9838_10535	COG1648	precorrin-2 dehydrogenase activity
K9838_10535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K9838_10545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K9838_10550	COG2223	nitrite transmembrane transporter activity
K9838_10555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K9838_10565	COG0243	molybdopterin cofactor binding
K9838_10585	COG3685	Protein conserved in bacteria
K9838_10605	COG3039	Transposase
K9838_10620	COG5001	Diguanylate cyclase
K9838_10630	COG4566	intracellular signal transduction
K9838_10710	COG1238	metal cluster binding
K9838_10730	COG1714	RDD family
K9838_10760	COG2207	Transcriptional regulator
K9838_10765	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_10850	COG3039	Transposase
K9838_10855	COG0640	Transcriptional regulator
K9838_10885	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_10890	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K9838_10895	COG1073	alpha beta
K9838_10895	COG2226	methyltransferase
K9838_10910	COG0363	glucosamine-6-phosphate deaminase activity
K9838_10950	COG0596	Alpha beta hydrolase
K9838_10960	COG1309	transcriptional regulator
K9838_10975	COG2154	pterin-4-alpha-carbinolamine dehydratase
K9838_10985	COG0428	transporter
K9838_10990	COG3064	Membrane
K9838_11000	COG1530	ribonuclease E activity
K9838_11010	COG1054	Belongs to the UPF0176 family
K9838_11030	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K9838_11055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K9838_11060	COG0322	excinuclease ABC activity
K9838_11070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K9838_11075	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K9838_11080	COG1663	tetraacyldisaccharide 4'-kinase activity
K9838_11085	COG1132	(ABC) transporter
K9838_11095	COG0811	peptide transport
K9838_11110	COG1136	(ABC) transporter
K9838_11115	COG4591	ABC-type transport system involved in lipoprotein release permease component
K9838_11125	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K9838_11130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K9838_11145	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K9838_11160	COG0354	folic acid binding
K9838_11170	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K9838_11175	COG0837	glucose binding
K9838_11180	COG0363	glucosamine-6-phosphate deaminase activity
K9838_11185	COG0129	dihydroxy-acid dehydratase activity
K9838_11190	COG0800	Aldolase
K9838_11255	COG0784	Response regulator, receiver
K9838_11255	COG2205	protein histidine kinase activity
K9838_11260	COG2183	response to ionizing radiation
K9838_11270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9838_11270	COG0723	plastoquinol--plastocyanin reductase activity
K9838_11285	COG3243	poly(R)-hydroxyalkanoic acid synthase
K9838_11295	COG1183	phosphatidylcholine synthase activity
K9838_11300	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_11315	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K9838_11325	COG0668	transmembrane transport
K9838_11330	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K9838_11345	COG1914	H( )-stimulated, divalent metal cation uptake system
K9838_11365	COG2814	Major facilitator Superfamily
K9838_11370	COG1228	amidohydrolase
K9838_11380	COG1335	isochorismatase
K9838_11395	COG2197	response regulator
K9838_11415	COG2201	protein-glutamate methylesterase activity
K9838_11425	COG0583	DNA-binding transcription factor activity
K9838_11430	COG0583	DNA-binding transcription factor activity
K9838_11435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K9838_11440	COG3002	Belongs to the UPF0753 family
K9838_11455	COG3384	dioxygenase
K9838_11470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K9838_11470	COG0519	Catalyzes the synthesis of GMP from XMP
K9838_11480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K9838_11490	COG0475	glutathione-regulated potassium exporter activity
K9838_11490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K9838_11495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K9838_11505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K9838_11510	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K9838_11520	COG0776	regulation of translation
K9838_11525	COG0539	negative regulation of cytoplasmic translation
K9838_11530	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K9838_11545	COG2957	Belongs to the agmatine deiminase family
K9838_11550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K9838_11575	COG0395	ABC-type sugar transport system, permease component
K9838_11580	COG1175	transmembrane transport
K9838_11610	COG2350	Protein conserved in bacteria
K9838_11615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K9838_11620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K9838_11625	COG1187	pseudouridine synthase activity
K9838_11645	COG0436	Aminotransferase
K9838_11650	COG4133	protoheme IX ABC transporter activity
K9838_11670	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K9838_11695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K9838_11700	COG1278	Cold shock
K9838_11705	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K9838_11710	COG4988	ABC transporter
K9838_11720	COG1294	oxidase, subunit
K9838_11750	COG3039	Transposase
K9838_11755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K9838_11760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K9838_11770	COG0165	Argininosuccinate lyase
K9838_11775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K9838_11785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K9838_11790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K9838_11800	COG0137	argininosuccinate synthase activity
K9838_11805	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K9838_11815	COG0215	cysteine-tRNA ligase activity
K9838_11820	COG2166	iron-sulfur cluster assembly
K9838_11840	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K9838_11845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K9838_11870	COG4302	ethanolamine ammonia-lyase activity
K9838_11885	COG4677	pectinesterase activity
K9838_11900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K9838_11905	COG0402	S-adenosylhomocysteine deaminase activity
K9838_11915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K9838_11920	COG1509	lysine 2,3-aminomutase activity
K9838_11925	COG3300	MHYT domain
K9838_11925	COG5001	Diguanylate cyclase
K9838_11940	COG0483	inositol monophosphate 1-phosphatase activity
K9838_11945	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K9838_11960	COG0488	(ABC) transporter
K9838_11965	COG0513	Belongs to the DEAD box helicase family
K9838_11970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K9838_11975	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K9838_11985	COG0625	glutathione transferase activity
K9838_11995	COG4681	YaeQ
K9838_12000	COG2081	HI0933 family
K9838_12010	COG0501	Belongs to the peptidase M48B family
K9838_12015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K9838_12020	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_12040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K9838_12045	COG0860	N-Acetylmuramoyl-L-alanine amidase
K9838_12050	COG0802	atpase or kinase
K9838_12055	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K9838_12055	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K9838_12060	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K9838_12065	COG1570	exodeoxyribonuclease VII activity
K9838_12075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K9838_12120	COG0835	chemotaxis
K9838_12125	COG0840	transmembrane signaling receptor activity
K9838_12130	COG2094	Belongs to the DNA glycosylase MPG family
K9838_12135	COG1201	RNA secondary structure unwinding
K9838_12155	COG2969	positive regulation of protein catabolic process
K9838_12160	COG0625	glutathione transferase activity
K9838_12165	COG2857	Cytochrome c1
K9838_12170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K9838_12175	COG0723	plastoquinol--plastocyanin reductase activity
K9838_12180	COG0741	lytic transglycosylase activity
K9838_12195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K9838_12200	COG1702	phosphate starvation-inducible protein PhoH
K9838_12210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K9838_12220	COG4535	Mg2 and Co2 transporter CorC
K9838_12235	COG1012	belongs to the aldehyde dehydrogenase family
K9838_12240	COG1177	transmembrane transport
K9838_12245	COG1176	ABC-type spermidine putrescine transport system, permease component I
K9838_12250	COG3842	ATPase activity
K9838_12270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K9838_12285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K9838_12290	COG0174	glutamine synthetase
K9838_12295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9838_12305	COG0477	Major facilitator Superfamily
K9838_12315	COG0784	Response regulator, receiver
K9838_12315	COG2205	protein histidine kinase activity
K9838_12315	COG5002	protein histidine kinase activity
K9838_12325	COG0243	molybdopterin cofactor binding
K9838_12330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K9838_12335	COG2223	nitrite transmembrane transporter activity
K9838_12345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K9838_12355	COG2733	membrane
K9838_12360	COG5002	protein histidine kinase activity
K9838_12360	COG2205	protein histidine kinase activity
K9838_12360	COG0784	Response regulator, receiver
K9838_12370	COG0477	Major facilitator Superfamily
K9838_12400	COG2902	Dehydrogenase
K9838_12410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9838_12415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K9838_12420	COG1609	Transcriptional regulator
K9838_12425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K9838_12425	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K9838_12430	COG1105	Belongs to the carbohydrate kinase PfkB family
K9838_12435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K9838_12435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K9838_12475	COG3039	Transposase
K9838_12495	COG3039	Transposase
K9838_12515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K9838_12525	COG1862	Preprotein translocase
K9838_12530	COG0343	queuine tRNA-ribosyltransferase activity
K9838_12535	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K9838_12570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K9838_12580	COG3291	Pkd domain containing protein
K9838_12585	COG0405	Gamma-glutamyltransferase
K9838_12590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K9838_12600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K9838_12605	COG0742	ribosomal rna small subunit methyltransferase
K9838_12610	COG0326	Molecular chaperone. Has ATPase activity
K9838_12695	COG0531	amino acid
K9838_12710	COG0006	proline dipeptidase activity
K9838_12720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K9838_12735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9838_12740	COG3938	Belongs to the proline racemase family
K9838_12750	COG0552	protein localization to endoplasmic reticulum
K9838_12755	COG1194	a g-specific adenine glycosylase
K9838_12775	COG0784	Response regulator, receiver
K9838_12775	COG4191	Histidine kinase
K9838_12790	COG0322	excinuclease ABC activity
K9838_12850	COG2944	sequence-specific DNA binding
K9838_12890	COG1196	nuclear chromosome segregation
K9838_12955	COG0616	signal peptide processing
K9838_13210	COG3040	lipid binding
K9838_13220	COG1960	acyl-CoA dehydrogenase activity
K9838_13230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K9838_13250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K9838_13260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K9838_13285	COG0438	transferase activity, transferring glycosyl groups
K9838_13295	COG0438	transferase activity, transferring glycosyl groups
K9838_13300	COG0438	transferase activity, transferring glycosyl groups
K9838_13350	COG0072	phenylalanine-tRNA ligase activity
K9838_13350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K9838_13355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K9838_13370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K9838_13375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K9838_13390	COG2211	Major facilitator Superfamily
K9838_13400	COG1082	Xylose isomerase domain protein TIM barrel
K9838_13425	COG3039	Transposase
K9838_13480	COG3702	type iv secretory pathway
K9838_13500	COG2948	multi-organism process
K9838_13520	COG3505	Type IV secretory pathway VirD4
K9838_13535	COG0556	nucleotide-excision repair
K9838_13585	COG3039	Transposase
K9838_13620	COG3275	phosphorelay sensor kinase activity
K9838_13625	COG1611	Belongs to the LOG family
K9838_13655	COG3039	Transposase
K9838_13660	COG2095	MarC family integral membrane protein
K9838_13670	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K9838_13705	COG1185	polyribonucleotide nucleotidyltransferase activity
K9838_13710	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K9838_13715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K9838_13720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K9838_13725	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K9838_13730	COG0195	Participates in both transcription termination and antitermination
K9838_13735	COG0779	Required for maturation of 30S ribosomal subunits
K9838_13745	COG1007	ATP synthesis coupled electron transport
K9838_13770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K9838_13775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K9838_13785	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K9838_13790	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K9838_13795	COG0649	NAD binding
K9838_13800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K9838_13805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K9838_13810	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K9838_13825	COG0149	triose-phosphate isomerase activity
K9838_13830	COG4221	oxidoreductase activity
K9838_13860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K9838_13865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K9838_13870	COG0159	tryptophan synthase activity
K9838_13880	COG0133	tryptophan synthase activity
K9838_13890	COG0135	phosphoribosylanthranilate isomerase activity
K9838_13895	COG0101	tRNA pseudouridine synthase activity
K9838_13910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K9838_13915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K9838_13920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K9838_13925	COG2890	protein-(glutamine-N5) methyltransferase activity
K9838_13935	COG0688	phosphatidylethanolamine metabolic process
K9838_13945	COG0433	COG0433 Predicted ATPase
K9838_13965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K9838_13970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K9838_13995	COG0717	Belongs to the dCTP deaminase family
K9838_14000	COG0489	protein tyrosine kinase activity
K9838_14020	COG3590	peptidase
K9838_14045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K9838_14050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9838_14055	COG2311	Membrane
K9838_14060	COG1047	Peptidyl-prolyl cis-trans
K9838_14065	COG0791	NLP P60 protein
K9838_14070	COG0791	NLP P60 protein
K9838_14085	COG1301	dicarboxylic acid transport
K9838_14090	COG1785	Belongs to the alkaline phosphatase family
K9838_14095	COG0037	tRNA processing
K9838_14100	COG1722	exodeoxyribonuclease VII activity
K9838_14105	COG0142	geranyltranstransferase activity
K9838_14110	COG4104	PAAR repeat-containing protein
K9838_14120	COG0312	modulator of DNA gyrase
K9838_14125	COG3028	Belongs to the UPF0307 family
K9838_14130	COG0312	modulator of DNA gyrase
K9838_14140	COG3164	Protein of unknown function
K9838_14150	COG0424	maF-like protein
K9838_14155	COG2968	Membrane
K9838_14180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K9838_14195	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K9838_14210	COG0495	leucyl-tRNA aminoacylation
K9838_14220	COG3118	belongs to the thioredoxin family
K9838_14245	COG2155	Conserved Protein
K9838_14310	COG1132	(ABC) transporter
K9838_14340	COG0745	RESPONSE REGULATOR receiver
K9838_14345	COG5000	phosphorelay sensor kinase activity
K9838_14345	COG5002	protein histidine kinase activity
K9838_14350	COG0475	glutathione-regulated potassium exporter activity
K9838_14360	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K9838_14380	COG1187	pseudouridine synthase activity
K9838_14385	COG5001	Diguanylate cyclase
K9838_14385	COG5002	protein histidine kinase activity
K9838_14500	COG0667	Aldo Keto reductase
K9838_14505	COG2814	Major facilitator Superfamily
K9838_14510	COG0583	DNA-binding transcription factor activity
K9838_14520	COG2207	Transcriptional regulator
K9838_14530	COG1309	transcriptional regulator
K9838_14555	COG0735	belongs to the Fur family
K9838_14560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K9838_14585	COG4452	Inner membrane protein CreD
K9838_14595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K9838_14600	COG2205	protein histidine kinase activity
K9838_14605	COG0745	RESPONSE REGULATOR receiver
K9838_14610	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K9838_14620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K9838_14630	COG0643	Histidine kinase
K9838_14630	COG2198	Histidine kinase
K9838_14635	COG0840	transmembrane signaling receptor activity
K9838_14640	COG0835	chemotaxis
K9838_14645	COG2200	EAL domain
K9838_14645	COG2202	Pas domain
K9838_14645	COG2199	diguanylate cyclase activity
K9838_14650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K9838_14655	COG2201	protein-glutamate methylesterase activity
K9838_14660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K9838_14665	COG3590	peptidase
K9838_14680	COG0588	phosphoglycerate mutase activity
K9838_14685	COG1515	deoxyribonuclease V activity
K9838_14710	COG1741	Belongs to the pirin family
K9838_14715	COG1966	Carbon starvation protein
K9838_14720	COG2879	small protein
K9838_14755	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K9838_14760	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K9838_14765	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K9838_14770	COG2080	2 iron, 2 sulfur cluster binding
K9838_14775	COG3321	synthase
K9838_14775	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_14775	COG0604	alcohol dehydrogenase
K9838_14780	COG5001	Diguanylate cyclase
K9838_14780	COG3706	GGDEF domain
K9838_14780	COG2203	Gaf domain
K9838_14780	COG4251	negative regulation of phosphorylation
K9838_14785	COG0629	single-stranded DNA binding
K9838_14790	COG0142	geranyltranstransferase activity
K9838_14800	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K9838_14815	COG0527	aspartate kinase activity
K9838_14820	COG0384	phenazine biosynthesis protein PhzF
K9838_14825	COG0384	phenazine biosynthesis protein PhzF
K9838_14835	COG1764	response to oxidative stress
K9838_14840	COG0540	Belongs to the ATCase OTCase family
K9838_14845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K9838_14850	COG1678	Uncharacterized ACR, COG1678
K9838_14855	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
K9838_14860	COG0519	Catalyzes the synthesis of GMP from XMP
K9838_14885	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K9838_14900	COG0739	heme binding
K9838_14920	COG0693	protein deglycase activity
K9838_14935	COG0719	Fe-S assembly protein
K9838_14940	COG0396	ATPase activity
K9838_14945	COG0719	Fe-S assembly protein
K9838_14950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K9838_14955	COG0456	acetyltransferase
K9838_14960	COG2146	nitrite reductase [NAD(P)H] activity
K9838_14965	COG4774	siderophore transport
K9838_14970	COG3128	pkhd-type hydroxylase
K9838_14995	COG1477	protein flavinylation
K9838_15010	COG1555	photosystem II stabilization
K9838_15015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K9838_15030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K9838_15040	COG0628	permease
K9838_15050	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K9838_15065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K9838_15085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K9838_15090	COG0271	Belongs to the BolA IbaG family
K9838_15100	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K9838_15110	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K9838_15115	COG1137	ATPase activity
K9838_15130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K9838_15135	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K9838_15140	COG1660	Displays ATPase and GTPase activities
K9838_15150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K9838_15155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K9838_15165	COG2239	Acts as a magnesium transporter
K9838_15175	COG1294	oxidase, subunit
K9838_15180	COG1271	oxidase subunit
K9838_15190	COG1113	amino acid transport
K9838_15215	COG2197	response regulator
K9838_15220	COG0531	amino acid
K9838_15260	COG3039	Transposase
K9838_15285	COG2814	Major facilitator Superfamily
K9838_15290	COG0754	glutathionylspermidine amidase activity
K9838_15315	COG1842	Phage shock protein A
K9838_15325	COG0259	pyridoxamine-phosphate oxidase activity
K9838_15330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K9838_15335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K9838_15345	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K9838_15350	COG2814	Major facilitator Superfamily
K9838_15375	COG0784	Response regulator, receiver
K9838_15375	COG2205	protein histidine kinase activity
K9838_15375	COG2198	Histidine kinase
K9838_15380	COG2353	YceI-like domain
K9838_15400	COG1760	l-serine dehydratase
K9838_15410	COG0527	aspartate kinase activity
K9838_15410	COG0460	homoserine dehydrogenase
K9838_15415	COG0626	cystathionine gamma-synthase activity
K9838_15420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K9838_15425	COG0739	heme binding
K9838_15430	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K9838_15435	COG1272	protein, Hemolysin III
K9838_15440	COG2982	Protein involved in outer membrane biogenesis
K9838_15445	COG0517	IMP dehydrogenase activity
K9838_15445	COG0516	GMP reductase activity
K9838_15450	COG0463	Glycosyl transferase, family 2
K9838_15455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K9838_15460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K9838_15470	COG4771	TonB-dependent receptor
K9838_15475	COG1309	transcriptional regulator
K9838_15485	COG1960	acyl-CoA dehydrogenase activity
K9838_15515	COG0509	glycine decarboxylation via glycine cleavage system
K9838_15520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K9838_15530	COG0330	HflC and HflK could
K9838_15535	COG1742	UPF0060 membrane protein
K9838_15540	COG3956	TIGRFAM MazG family protein
K9838_15550	COG0494	nUDIX hydrolase
K9838_15560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K9838_15565	COG0837	glucose binding
K9838_15580	COG3858	chitin binding
K9838_15580	COG1388	LysM domain
K9838_15585	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K9838_15595	COG1472	Belongs to the glycosyl hydrolase 3 family
K9838_15605	COG3537	Alpha-1,2-mannosidase
K9838_15640	COG3142	Participates in the control of copper homeostasis
K9838_15670	COG0784	Response regulator, receiver
K9838_15670	COG2198	Histidine kinase
K9838_15670	COG0643	Histidine kinase
K9838_15675	COG0840	transmembrane signaling receptor activity
K9838_15680	COG0835	chemotaxis
K9838_15695	COG0189	ligase activity
K9838_15705	COG1397	ADP-ribosylglycohydrolase
K9838_15715	COG1199	ATP-dependent helicase activity
K9838_15725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K9838_15730	COG1215	transferase activity, transferring glycosyl groups
K9838_15740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K9838_15755	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
K9838_15760	COG0535	radical SAM domain protein
K9838_15765	COG0535	radical SAM domain protein
K9838_15775	COG3039	Transposase
K9838_15785	COG0837	glucose binding
K9838_15795	COG1643	Atp-dependent helicase
K9838_15800	COG0783	Belongs to the Dps family
K9838_15805	COG0514	ATP-dependent DNA helicase (RecQ)
K9838_15835	COG0840	transmembrane signaling receptor activity
K9838_15860	COG3920	Histidine kinase
K9838_15865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K9838_15875	COG0602	queuosine metabolic process
K9838_15885	COG2885	chlorophyll binding
K9838_15890	COG0823	Involved in the tonB-independent uptake of proteins
K9838_15900	COG0848	biopolymer transport protein
K9838_15910	COG0824	Thioesterase
K9838_15915	COG2255	four-way junction helicase activity
K9838_15925	COG3158	transport of potassium into the cell
K9838_15930	COG0632	four-way junction helicase activity
K9838_15935	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K9838_15940	COG0217	transcriptional regulatory protein
K9838_15955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K9838_15970	COG0477	Major facilitator Superfamily
K9838_15990	COG0657	acetylesterase activity
K9838_15990	COG2755	lipolytic protein G-D-S-L family
K9838_16010	COG0488	(ABC) transporter
K9838_16040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K9838_16040	COG4651	solute:proton antiporter activity
K9838_16065	COG4772	TonB-dependent receptor
K9838_16075	COG4264	IucA IucC family
K9838_16080	COG2814	Major facilitator Superfamily
K9838_16090	COG0019	diaminopimelate decarboxylase activity
K9838_16115	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K9838_16125	COG1492	cobalamin metabolic process
K9838_16135	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K9838_16160	COG4206	TonB-dependent receptor
K9838_16170	COG0542	response to heat
K9838_16215	COG1877	trehalose-phosphatase activity
K9838_16220	COG3387	PFAM Glycoside hydrolase 15-related
K9838_16235	COG0840	transmembrane signaling receptor activity
K9838_16240	COG3011	Protein conserved in bacteria
K9838_16255	COG0564	pseudouridine synthase activity
K9838_16260	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K9838_16270	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K9838_16270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K9838_16285	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K9838_16290	COG0045	succinate-CoA ligase (ADP-forming) activity
K9838_16320	COG1459	type II secretion system
K9838_16325	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K9838_16330	COG0237	dephospho-CoA kinase activity
K9838_16350	COG0745	RESPONSE REGULATOR receiver
K9838_16360	COG0189	ligase activity
K9838_16440	COG2022	thiamine diphosphate biosynthetic process
K9838_16445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K9838_16450	COG0471	metal ion transport
K9838_16450	COG3273	potassium ion transport
K9838_16475	COG1970	mechanosensitive ion channel activity
K9838_16485	COG1609	Transcriptional regulator
K9838_16510	COG3250	beta-galactosidase activity
K9838_16515	COG4948	Mandelate Racemase Muconate Lactonizing
K9838_16525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K9838_16535	COG0308	aminopeptidase N
K9838_16545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9838_16550	COG0529	Catalyzes the synthesis of activated sulfate
K9838_16550	COG2895	sulfate adenylyltransferase (ATP) activity
K9838_16555	COG0175	sulfate reduction
K9838_16560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K9838_16565	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K9838_16570	COG0175	sulfate reduction
K9838_16590	COG2205	protein histidine kinase activity
K9838_16590	COG0784	Response regulator, receiver
K9838_16590	COG2198	Histidine kinase
K9838_16605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K9838_16605	COG1648	precorrin-2 dehydrogenase activity
K9838_16620	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K9838_16625	COG3588	fructose-bisphosphate aldolase
K9838_16630	COG0469	pyruvate kinase activity
K9838_16640	COG0126	phosphoglycerate kinase activity
K9838_16670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K9838_16680	COG3047	cAMP biosynthetic process
K9838_16695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K9838_16695	COG3453	Protein conserved in bacteria
K9838_16700	COG0725	ABC transporter, periplasmic molybdate-binding protein
K9838_16705	COG4149	molybdate abc transporter
K9838_16710	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K9838_16730	COG0642	Histidine kinase
K9838_16755	COG1022	Amp-dependent synthetase and ligase
K9838_16780	COG1376	ErfK ybiS ycfS ynhG family protein
K9838_16785	COG0739	heme binding
K9838_16790	COG4773	Receptor
K9838_16800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K9838_16805	COG1301	dicarboxylic acid transport
K9838_16815	COG2304	oxidoreductase activity
K9838_16835	COG0714	Associated with various cellular activities
K9838_16865	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K9838_16885	COG1957	nucleoside hydrolase
K9838_16890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K9838_16900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K9838_16915	COG1561	YicC-like family, N-terminal region
K9838_16920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K9838_16925	COG0346	lactoylglutathione lyase activity
K9838_16930	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K9838_16935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K9838_16950	COG0006	proline dipeptidase activity
K9838_16960	COG0006	proline dipeptidase activity
K9838_16965	COG3079	Belongs to the UPF0149 family
K9838_16985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K9838_17005	COG2912	Transglutaminase-like superfamily
K9838_17010	COG1773	rubredoxin
K9838_17015	COG0352	thiamine-phosphate diphosphorylase activity
K9838_17025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K9838_17035	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K9838_17040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K9838_17070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K9838_17075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K9838_17080	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_17090	COG0671	phosphoesterase, PA-phosphatase related
K9838_17095	COG3781	membrane
K9838_17105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K9838_17110	COG0563	adenylate kinase activity
K9838_17125	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K9838_17135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K9838_17155	COG3710	Transcriptional regulator
K9838_17160	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K9838_17170	COG0840	transmembrane signaling receptor activity
K9838_17180	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K9838_17200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K9838_17205	COG0473	3-isopropylmalate dehydrogenase activity
K9838_17210	COG0066	3-isopropylmalate dehydratase activity
K9838_17215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K9838_17235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K9838_17240	COG1538	Outer membrane efflux protein
K9838_17245	COG1519	Transferase
K9838_17250	COG1560	Kdo2-lipid A biosynthetic process
K9838_17275	COG0280	phosphate acetyltransferase
K9838_17275	COG0281	malic enzyme
K9838_17280	COG1301	dicarboxylic acid transport
K9838_17305	COG0583	DNA-binding transcription factor activity
K9838_17310	COG0667	Aldo Keto reductase
K9838_17325	COG2197	response regulator
K9838_17335	COG0642	Histidine kinase
K9838_17350	COG2851	Citrate transporter
K9838_17355	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_17360	COG1609	Transcriptional regulator
K9838_17365	COG2211	Major facilitator Superfamily
K9838_17390	COG1162	GTPase activity
K9838_17395	COG0436	Aminotransferase
K9838_17410	COG0726	polysaccharide deacetylase
K9838_17415	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K9838_17430	COG3964	amidohydrolase
K9838_17435	COG0402	S-adenosylhomocysteine deaminase activity
K9838_17455	COG1307	EDD domain protein, DegV family
K9838_17460	COG0242	peptide deformylase activity
K9838_17505	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K9838_17510	COG1215	transferase activity, transferring glycosyl groups
K9838_17515	COG1215	transferase activity, transferring glycosyl groups
K9838_17530	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K9838_17575	COG2188	Transcriptional regulator
K9838_17590	COG1450	Type ii and iii secretion system protein
K9838_17605	COG3166	PFAM Fimbrial assembly family protein
K9838_17610	COG3156	type II secretion system protein K
K9838_17615	COG4795	General secretion pathway protein
K9838_17620	COG2165	general secretion pathway protein
K9838_17625	COG4970	Tfp pilus assembly protein FimT
K9838_17630	COG2165	general secretion pathway protein
K9838_17635	COG1459	type II secretion system
K9838_17640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K9838_17645	COG1404	Belongs to the peptidase S8 family
K9838_17650	COG5295	Hep Hag repeat protein
K9838_17655	COG1404	Belongs to the peptidase S8 family
K9838_17660	COG5295	Hep Hag repeat protein
K9838_17665	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K9838_17665	COG0047	phosphoribosylformylglycinamidine synthase activity
K9838_17670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K9838_17680	COG4974	Belongs to the 'phage' integrase family
K9838_17695	COG0795	lipopolysaccharide-transporting ATPase activity
K9838_17705	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K9838_17720	COG0525	valine-tRNA ligase activity
K9838_17755	COG1183	phosphatidylcholine synthase activity
K9838_17765	COG0442	prolyl-tRNA aminoacylation
K9838_17780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K9838_17785	COG1127	ABC transporter
K9838_17790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K9838_17790	COG3218	ABC-type transport auxiliary lipoprotein component
K9838_17825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K9838_17830	COG0662	Cupin 2, conserved barrel domain protein
K9838_17830	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K9838_17860	COG2086	electron transfer activity
K9838_17875	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K9838_17875	COG0546	phosphoglycolate phosphatase activity
K9838_17880	COG0277	FAD linked oxidase domain protein
K9838_17895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K9838_17935	COG3039	Transposase
K9838_17950	COG0438	transferase activity, transferring glycosyl groups
K9838_17950	COG1216	Glycosyl transferase, family 2
K9838_17975	COG0626	cystathionine gamma-synthase activity
K9838_18005	COG0625	glutathione transferase activity
K9838_18015	COG0513	Belongs to the DEAD box helicase family
K9838_18020	COG0720	synthase
K9838_18030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K9838_18040	COG1956	GAF domain-containing protein
K9838_18055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K9838_18060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K9838_18070	COG4991	sh3 domain protein
K9838_18080	COG0339	signal peptide processing
K9838_18095	COG2132	Multicopper oxidase
K9838_18130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K9838_18135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9838_18140	COG1136	(ABC) transporter
K9838_18155	COG1136	(ABC) transporter
K9838_18155	COG0577	efflux transmembrane transporter activity
K9838_18175	COG4191	Histidine kinase
K9838_18180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K9838_18195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K9838_18200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K9838_18205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K9838_18210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K9838_18215	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K9838_18220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K9838_18230	COG0356	it plays a direct role in the translocation of protons across the membrane
K9838_18250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K9838_18260	COG0508	dehydrogenase complex catalyzes the overall conversion of
K9838_18300	COG2011	ABC-type metal ion transport system permease component
K9838_18305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K9838_18310	COG0697	spore germination
K9838_18315	COG1666	GTP binding
K9838_18325	COG0784	Response regulator, receiver
K9838_18325	COG2198	Histidine kinase
K9838_18325	COG5002	protein histidine kinase activity
K9838_18350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K9838_18360	COG2813	Specifically methylates the guanine in position
K9838_18385	COG2202	Pas domain
K9838_18385	COG2205	protein histidine kinase activity
K9838_18405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K9838_18410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9838_18465	COG0842	Transport permease protein
K9838_18470	COG1131	(ABC) transporter
K9838_18475	COG0025	NhaP-type Na H and K H
K9838_18480	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K9838_18485	COG1573	uracil-dna glycosylase
K9838_18495	COG3384	dioxygenase
K9838_18505	COG0583	DNA-binding transcription factor activity
K9838_18515	COG0667	Aldo Keto reductase
K9838_18530	COG3590	peptidase
K9838_18550	COG0531	amino acid
K9838_18565	COG2972	Histidine kinase
K9838_18580	COG3685	Protein conserved in bacteria
K9838_18585	COG3546	catalase activity
K9838_18635	COG1271	oxidase subunit
K9838_18640	COG1294	oxidase, subunit
K9838_18655	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_18670	COG3039	Transposase
K9838_18680	COG1063	alcohol dehydrogenase
K9838_18765	COG0251	oxidation-reduction process
K9838_18780	COG0840	transmembrane signaling receptor activity
K9838_18810	COG0659	secondary active sulfate transmembrane transporter activity
K9838_18815	COG0038	chloride channel
K9838_18825	COG0024	Methionine aminopeptidase
K9838_18855	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_18875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K9838_18880	COG1490	D-aminoacyl-tRNA deacylase activity
K9838_18885	COG1560	Kdo2-lipid A biosynthetic process
K9838_18890	COG1247	-acetyltransferase
K9838_18930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K9838_18930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K9838_18935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K9838_18940	COG0242	peptide deformylase activity
K9838_18945	COG1652	LysM domain
K9838_18950	COG0758	DNA mediated transformation
K9838_18970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K9838_18970	COG1754	DNA topoisomerase type I activity
K9838_18975	COG0009	L-threonylcarbamoyladenylate synthase
K9838_18990	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_19000	COG0616	signal peptide processing
K9838_19005	COG0534	Mate efflux family protein
K9838_19025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K9838_19030	COG0625	glutathione transferase activity
K9838_19045	COG1252	NADH dehydrogenase
K9838_19050	COG2860	membrane
K9838_19055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K9838_19060	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K9838_19065	COG2201	protein-glutamate methylesterase activity
K9838_19070	COG2177	Part of the ABC transporter FtsEX involved in
K9838_19075	COG2884	Cell division ATP-binding protein ftsE
K9838_19085	COG3118	belongs to the thioredoxin family
K9838_19090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K9838_19100	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
K9838_19125	COG1652	LysM domain
K9838_19130	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K9838_19130	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K9838_19135	COG1473	amidohydrolase
K9838_19140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9838_19145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K9838_19155	COG5383	Protein conserved in bacteria
K9838_19195	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K9838_19205	COG4948	Mandelate Racemase Muconate Lactonizing
K9838_19215	COG0531	amino acid
K9838_19230	COG4682	membrane
K9838_19255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K9838_19260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K9838_19275	COG1295	ribonuclease BN
K9838_19280	COG0358	DNA primase activity
K9838_19295	COG0109	protoheme IX farnesyltransferase activity
K9838_19325	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K9838_19335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K9838_19380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K9838_19385	COG0739	heme binding
K9838_19390	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K9838_19400	COG2211	Major facilitator Superfamily
K9838_19405	COG0708	Exodeoxyribonuclease III
K9838_19410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K9838_19420	COG1192	Involved in chromosome partitioning
K9838_19425	COG1475	DNA binding
K9838_19440	COG0463	Glycosyl transferase, family 2
K9838_19465	COG0756	dUTP diphosphatase activity
K9838_19470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K9838_19475	COG2003	Belongs to the UPF0758 family
K9838_19480	COG0018	arginyl-trna synthetase
K9838_19495	COG4221	oxidoreductase activity
K9838_19500	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K9838_19500	COG2755	lipolytic protein G-D-S-L family
K9838_19510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K9838_19520	COG1166	arginine decarboxylase activity
K9838_19525	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K9838_19545	COG3291	Pkd domain containing protein
K9838_19545	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K9838_19630	COG1690	Belongs to the RtcB family
K9838_19655	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K9838_19740	COG1090	epimerase
K9838_19750	COG0642	Histidine kinase
K9838_19770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K9838_19795	COG1011	Hydrolase
K9838_19800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K9838_19815	COG0753	catalase activity
K9838_19830	COG2197	response regulator
K9838_19835	COG4585	Histidine kinase
K9838_19840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9838_19845	COG1136	(ABC) transporter
K9838_19870	COG0697	spore germination
K9838_19895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K9838_19900	COG0180	Tryptophanyl-tRNA synthetase
K9838_19945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K9838_20005	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K9838_20010	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K9838_20010	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K9838_20020	COG3228	Belongs to the MtfA family
K9838_20050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K9838_20095	COG1199	ATP-dependent helicase activity
K9838_20110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K9838_20160	COG0625	glutathione transferase activity
K9838_20200	COG4555	ABC transporter
K9838_20210	COG1476	TRANSCRIPTIONal
K9838_20230	COG1230	cation diffusion facilitator family transporter
K9838_20235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K9838_20240	COG1131	(ABC) transporter
K9838_20245	COG0842	Transport permease protein
K9838_20250	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K9838_20270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K9838_20290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K9838_20295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K9838_20305	COG0045	succinate-CoA ligase (ADP-forming) activity
K9838_20305	COG1042	CoA-binding domain protein
K9838_20305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K9838_20310	COG2239	Acts as a magnesium transporter
K9838_20325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K9838_20330	COG3387	PFAM Glycoside hydrolase 15-related
K9838_20345	COG3100	YcgL domain-containing protein
K9838_20350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K9838_20370	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_20425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K9838_20460	COG0408	coproporphyrinogen oxidase activity
K9838_20500	COG0515	serine threonine protein kinase
K9838_20505	COG0631	protein serine/threonine phosphatase activity
K9838_20530	COG0667	Aldo Keto reductase
K9838_20535	COG0583	DNA-binding transcription factor activity
K9838_20690	COG0210	DNA helicase
K9838_20710	COG0583	DNA-binding transcription factor activity
K9838_20715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K9838_20725	COG2159	amidohydrolase
K9838_20750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K9838_20770	COG0357	Ribosomal RNA small subunit methyltransferase G
K9838_20775	COG3540	Alkaline phosphatase
K9838_20785	COG2091	lysine biosynthetic process via aminoadipic acid
K9838_20800	COG0708	Exodeoxyribonuclease III
K9838_20805	COG1846	Transcriptional regulator
K9838_20805	COG1940	carbohydrate kinase activity
K9838_20815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K9838_20825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K9838_20830	COG3162	membrane
K9838_20840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K9838_20875	COG3507	Belongs to the glycosyl hydrolase 43 family
K9838_20895	COG1028	Short-chain dehydrogenase reductase Sdr
K9838_20900	COG0179	Fumarylacetoacetate (FAA) hydrolase
K9838_20905	COG4948	Mandelate Racemase Muconate Lactonizing
K9838_20910	COG3254	rhamnose metabolic process
K9838_20915	COG0738	Major facilitator superfamily
K9838_20920	COG1414	Transcriptional regulator
K9838_20925	COG1917	Cupin 2, conserved barrel domain protein
K9838_20925	COG2207	Transcriptional regulator
K9838_20935	COG1971	Probably functions as a manganese efflux pump
K9838_20940	COG2205	protein histidine kinase activity
K9838_20950	COG3459	Glycosyltransferase 36 associated
K9838_20955	COG2211	Major facilitator Superfamily
K9838_20960	COG3265	gluconokinase activity
K9838_20965	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K9838_20985	COG2911	Protein conserved in bacteria
K9838_20990	COG0729	surface antigen
K9838_20995	COG4771	TonB-dependent receptor
K9838_21000	COG0457	Tetratricopeptide repeat
K9838_21010	COG0752	glycyl-tRNA synthetase alpha subunit
K9838_21015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K9838_21025	COG0519	Catalyzes the synthesis of GMP from XMP
K9838_21025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K9838_21035	COG0805	protein transport
K9838_21040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K9838_21045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K9838_21055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K9838_21075	COG2974	May be involved in recombination
K9838_21080	COG0037	tRNA processing
K9838_21085	COG2115	Belongs to the xylose isomerase family
K9838_21095	COG3661	Belongs to the glycosyl hydrolase 67 family
K9838_21105	COG4948	Mandelate Racemase Muconate Lactonizing
K9838_21115	COG1472	Belongs to the glycosyl hydrolase 3 family
K9838_21120	COG0246	Mannitol dehydrogenase
K9838_21180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K9838_21205	COG3386	PFAM SMP-30 Gluconolaconase
K9838_21220	COG1904	glucuronate isomerase
K9838_21235	COG3693	PFAM glycoside hydrolase, family 10
K9838_21250	COG2211	Major facilitator Superfamily
K9838_21295	COG2937	Belongs to the GPAT DAPAT family
K9838_21325	COG0284	orotidine-5'-phosphate decarboxylase activity
K9838_21330	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
K9838_21335	COG3132	Protein of unknown function, DUF480
K9838_21345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K9838_21400	COG0210	DNA helicase
K9838_21405	COG1435	thymidine kinase activity
K9838_21415	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K9838_21425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K9838_21455	COG3135	benzoate transporter
K9838_21475	COG0676	glucose-6-phosphate 1-epimerase activity
K9838_21485	COG3012	SEC-C Motif Domain Protein
K9838_21490	COG0730	response to heat
K9838_21515	COG0302	gtp cyclohydrolase
K9838_21530	COG1566	PFAM secretion protein HlyD family protein
K9838_21540	COG1289	transmembrane transporter activity
K9838_21545	COG0477	Major facilitator Superfamily
K9838_21555	COG0583	DNA-binding transcription factor activity
K9838_21560	COG4221	oxidoreductase activity
K9838_21570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K9838_21615	COG0564	pseudouridine synthase activity
K9838_21670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K9838_21675	COG1074	ATP-dependent DNA helicase activity
K9838_21680	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K9838_21715	COG1127	ABC transporter
K9838_21720	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K9838_21725	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K9838_21740	COG2853	Lipoprotein
K9838_21750	COG0386	Belongs to the glutathione peroxidase family
K9838_21760	COG1322	Protein conserved in bacteria
K9838_21770	COG0583	DNA-binding transcription factor activity
K9838_21790	COG0531	amino acid
K9838_21795	COG3537	Alpha-1,2-mannosidase
K9838_21810	COG2199	diguanylate cyclase activity
K9838_21810	COG2203	Gaf domain
K9838_21815	COG3835	regulator
K9838_21820	COG1929	Belongs to the glycerate kinase type-1 family
K9838_21840	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K9838_21845	COG0861	Integral membrane protein TerC family
K9838_21855	COG0584	glycerophosphoryl diester phosphodiesterase
K9838_21870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K9838_21875	COG0726	polysaccharide deacetylase
K9838_21885	COG0706	membrane insertase activity
K9838_21890	COG0594	ribonuclease P activity
K9838_21940	COG3039	Transposase
K9838_22000	COG4453	Protein conserved in bacteria
K9838_22025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K9838_22045	COG2948	multi-organism process
K9838_22050	COG3504	Conjugal transfer protein
K9838_22080	COG3451	type IV secretory pathway VirB4
K9838_22135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K9838_22200	COG2201	protein-glutamate methylesterase activity
K9838_22245	COG1192	Involved in chromosome partitioning
K9838_22310	COG1192	Involved in chromosome partitioning
K9838_22370	COG1475	DNA binding
K9838_22390	COG2885	chlorophyll binding
K9838_22470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K9838_22685	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K9838_22730	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K9838_22750	COG3012	SEC-C Motif Domain Protein
K9838_22750	COG3318	Belongs to the UPF0149 family
K9838_22780	COG3846	protein secretion by the type IV secretion system
K9838_22805	COG3504	Conjugal transfer protein
K9838_22815	COG3451	type IV secretory pathway VirB4
K9838_22830	COG4962	Type ii secretion system protein e
K9838_22840	COG0629	single-stranded DNA binding