locus-tag	class	description
J6335_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J6335_00020	COG0187	DNA topoisomerase II activity
J6335_00030	COG0501	Belongs to the peptidase M48B family
J6335_00075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J6335_00085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J6335_00130	COG0793	Belongs to the peptidase S41A family
J6335_00135	COG4942	peptidase
J6335_00145	COG2234	aminopeptidase activity
J6335_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J6335_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J6335_00170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J6335_00175	COG1064	alcohol dehydrogenase
J6335_00190	COG0493	'glutamate synthase
J6335_00195	COG0067	glutamate synthase
J6335_00195	COG0069	glutamate synthase activity
J6335_00195	COG0070	glutamate synthase
J6335_00285	COG1205	dead DEAH box helicase
J6335_00285	COG1111	helicase
J6335_00290	COG1272	protein, Hemolysin III
J6335_00310	COG0300	oxidoreductase activity
J6335_00315	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_00340	COG2249	NAD(P)H dehydrogenase (quinone) activity
J6335_00350	COG3039	Transposase
J6335_00365	COG3039	Transposase
J6335_00375	COG3237	CsbD-like
J6335_00425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J6335_00430	COG0477	Major facilitator Superfamily
J6335_00475	COG0714	Associated with various cellular activities
J6335_00515	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
J6335_00525	COG4772	TonB-dependent receptor
J6335_00550	COG1304	FMN binding
J6335_00555	COG1755	Isoprenylcysteine carboxyl methyltransferase
J6335_00560	COG4585	Histidine kinase
J6335_00565	COG2197	response regulator
J6335_00590	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J6335_00640	COG3039	Transposase
J6335_00645	COG3039	Transposase
J6335_00660	COG0366	Alpha amylase catalytic
J6335_00665	COG0366	Alpha amylase catalytic
J6335_00670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J6335_00690	COG2755	lipolytic protein G-D-S-L family
J6335_00690	COG0657	acetylesterase activity
J6335_00700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J6335_00715	COG3507	Belongs to the glycosyl hydrolase 43 family
J6335_00720	COG1609	Transcriptional regulator
J6335_00725	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
J6335_00730	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_00740	COG2755	lipolytic protein G-D-S-L family
J6335_00750	COG3186	Phenylalanine-4-hydroxylase
J6335_00755	COG1522	sequence-specific DNA binding
J6335_00765	COG1752	Esterase of the alpha-beta hydrolase superfamily
J6335_00775	COG1119	ATPase activity
J6335_00790	COG0517	IMP dehydrogenase activity
J6335_00790	COG1125	glycine betaine transport
J6335_00805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J6335_00835	COG0489	protein tyrosine kinase activity
J6335_00840	COG2062	phosphohistidine phosphatase, SixA
J6335_00850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J6335_00890	COG1968	undecaprenyl-diphosphatase activity
J6335_00895	COG0174	glutamine synthetase
J6335_00900	COG0347	Belongs to the P(II) protein family
J6335_00905	COG0004	ammonium transporteR
J6335_00910	COG3852	Histidine kinase
J6335_00915	COG2204	response regulator
J6335_00920	COG2032	superoxide dismutase activity
J6335_00925	COG2032	superoxide dismutase activity
J6335_00940	COG0183	Belongs to the thiolase family
J6335_00975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J6335_00980	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
J6335_00985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J6335_01010	COG2205	protein histidine kinase activity
J6335_01035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J6335_01050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J6335_01055	COG3177	Filamentation induced by cAMP protein fic
J6335_01060	COG0596	Alpha beta hydrolase
J6335_01065	COG0727	PFAM Uncharacterised protein family (UPF0153)
J6335_01070	COG0318	PFAM AMP-dependent synthetase and ligase
J6335_01075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J6335_01090	COG1181	Belongs to the D-alanine--D-alanine ligase family
J6335_01100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J6335_01110	COG0564	pseudouridine synthase activity
J6335_01130	COG1446	asparaginase
J6335_01135	COG0339	signal peptide processing
J6335_01170	COG0475	glutathione-regulated potassium exporter activity
J6335_01180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J6335_01185	COG2224	Isocitrate lyase
J6335_01205	COG3039	Transposase
J6335_01225	COG4770	biotin carboxylase activity
J6335_01230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J6335_01235	COG1960	acyl-CoA dehydrogenase activity
J6335_01300	COG0697	spore germination
J6335_01310	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J6335_01315	COG1846	Transcriptional regulator
J6335_01320	COG1764	response to oxidative stress
J6335_01340	COG2130	NADP-dependent
J6335_01355	COG1187	pseudouridine synthase activity
J6335_01365	COG1643	Atp-dependent helicase
J6335_01370	COG4807	Protein conserved in bacteria
J6335_01380	COG2072	flavoprotein involved in K transport
J6335_01400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J6335_01410	COG0583	DNA-binding transcription factor activity
J6335_01445	COG2252	PERMEase
J6335_01465	COG0084	hydrolase, TatD family'
J6335_01480	COG0583	DNA-binding transcription factor activity
J6335_01485	COG2814	Major facilitator Superfamily
J6335_01500	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J6335_01505	COG1902	pentaerythritol trinitrate reductase activity
J6335_01525	COG0745	RESPONSE REGULATOR receiver
J6335_01530	COG2205	protein histidine kinase activity
J6335_01535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J6335_01560	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J6335_01565	COG0583	DNA-binding transcription factor activity
J6335_01600	COG0702	epimerase
J6335_01605	COG1733	regulation of RNA biosynthetic process
J6335_01620	COG3328	transposase activity
J6335_01660	COG0129	dihydroxy-acid dehydratase activity
J6335_01675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
J6335_01730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J6335_01735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J6335_01760	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J6335_01775	COG3485	protocatechuate 3,4-dioxygenase
J6335_01780	COG3485	protocatechuate 3,4-dioxygenase
J6335_01790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J6335_01795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J6335_01805	COG1414	Transcriptional regulator
J6335_01815	COG0657	acetylesterase activity
J6335_01825	COG0445	tRNA wobble uridine modification
J6335_01835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J6335_01865	COG2267	carboxylic ester hydrolase activity
J6335_01875	COG0156	8-amino-7-oxononanoate synthase activity
J6335_01880	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J6335_01885	COG1040	competence protein
J6335_01890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J6335_01910	COG3039	Transposase
J6335_01975	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J6335_02045	COG1511	domain protein
J6335_02045	COG3264	Mechanosensitive ion channel
J6335_02050	COG1368	sulfuric ester hydrolase activity
J6335_02055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J6335_02060	COG2354	Protein conserved in bacteria
J6335_02070	COG0297	glycogen (starch) synthase activity
J6335_02075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J6335_02080	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J6335_02105	COG0702	epimerase
J6335_02130	COG3328	transposase activity
J6335_02140	COG3039	Transposase
J6335_02155	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_02190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J6335_02195	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_02205	COG0513	Belongs to the DEAD box helicase family
J6335_02210	COG0508	dehydrogenase complex catalyzes the overall conversion of
J6335_02225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J6335_02235	COG3483	tryptophan 2,3-dioxygenase activity
J6335_02240	COG3104	oligopeptide transport
J6335_02260	COG2852	Protein conserved in bacteria
J6335_02265	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
J6335_02280	COG1320	monovalent cation:proton antiporter activity
J6335_02285	COG2212	antiporter activity
J6335_02295	COG0651	ATP synthesis coupled electron transport
J6335_02300	COG1006	Multisubunit Na H antiporter MnhC subunit
J6335_02305	COG2111	Na H antiporter
J6335_02305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J6335_02350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J6335_02355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J6335_02375	COG1597	lipid kinase activity
J6335_02405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J6335_02410	COG0134	indole-3-glycerol-phosphate synthase activity
J6335_02420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J6335_02425	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
J6335_02435	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
J6335_02445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J6335_02460	COG1051	belongs to the nudix hydrolase family
J6335_02500	COG0316	Belongs to the HesB IscA family
J6335_02515	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J6335_02530	COG2814	Major facilitator Superfamily
J6335_02540	COG2814	Major facilitator Superfamily
J6335_02545	COG1289	transmembrane transporter activity
J6335_02555	COG0151	Belongs to the GarS family
J6335_02565	COG0138	bifunctional purine biosynthesis protein purh
J6335_02570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J6335_02575	COG2267	carboxylic ester hydrolase activity
J6335_02580	COG2453	phosphatase
J6335_02580	COG0671	phosphoesterase, PA-phosphatase related
J6335_02605	COG4589	Belongs to the CDS family
J6335_02610	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
J6335_02630	COG2264	protein methyltransferase activity
J6335_02645	COG0439	Biotin carboxylase
J6335_02655	COG0511	ligase activity, forming carbon-carbon bonds
J6335_02660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J6335_02670	COG1324	tolerance protein
J6335_02690	COG0459	protein refolding
J6335_02705	COG3550	peptidyl-serine autophosphorylation
J6335_02710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J6335_02725	COG3386	PFAM SMP-30 Gluconolaconase
J6335_02735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J6335_02740	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J6335_02760	COG3039	Transposase
J6335_02780	COG0778	Nitroreductase
J6335_02785	COG2353	YceI-like domain
J6335_02820	COG3052	prosthetic group binding
J6335_02845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J6335_02855	COG1802	Transcriptional regulator
J6335_02910	COG3328	transposase activity
J6335_02925	COG4221	oxidoreductase activity
J6335_02950	COG4221	oxidoreductase activity
J6335_02960	COG0435	Glutathione S-transferase
J6335_03025	COG1959	2 iron, 2 sulfur cluster binding
J6335_03050	COG0697	spore germination
J6335_03055	COG4305	rare lipoprotein A
J6335_03060	COG5297	Belongs to the glycosyl hydrolase family 6
J6335_03070	COG1113	amino acid transport
J6335_03080	COG0598	Magnesium transport protein CorA
J6335_03125	COG3447	MASE1 domain protein
J6335_03125	COG5001	Diguanylate cyclase
J6335_03125	COG5002	protein histidine kinase activity
J6335_03135	COG0784	Response regulator, receiver
J6335_03135	COG2205	protein histidine kinase activity
J6335_03165	COG2943	transferase activity, transferring hexosyl groups
J6335_03175	COG3275	phosphorelay sensor kinase activity
J6335_03185	COG0181	hydroxymethylbilane synthase activity
J6335_03220	COG1505	serine-type exopeptidase activity
J6335_03230	COG0436	Aminotransferase
J6335_03240	COG2832	Protein of unknown function (DUF454)
J6335_03250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J6335_03260	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J6335_03265	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
J6335_03270	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J6335_03295	COG2226	methyltransferase
J6335_03300	COG3300	MHYT domain
J6335_03300	COG5001	Diguanylate cyclase
J6335_03305	COG0308	aminopeptidase N
J6335_03350	COG3284	Transcriptional regulator
J6335_03365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J6335_03370	COG1077	Cell shape determining protein MreB Mrl
J6335_03375	COG1792	Involved in formation and maintenance of cell shape
J6335_03390	COG0772	Belongs to the SEDS family
J6335_03405	COG3039	Transposase
J6335_03430	COG2951	lytic endotransglycosylase activity
J6335_03435	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J6335_03440	COG1686	Belongs to the peptidase S11 family
J6335_03450	COG2921	Belongs to the UPF0250 family
J6335_03455	COG0321	lipoyl(octanoyl) transferase activity
J6335_03460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J6335_03485	COG1051	belongs to the nudix hydrolase family
J6335_03485	COG1056	cytidyltransferase-related domain
J6335_03520	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J6335_03525	COG0673	inositol 2-dehydrogenase activity
J6335_03530	COG2823	Periplasmic or secreted lipoprotein
J6335_03535	COG4251	negative regulation of phosphorylation
J6335_03540	COG0784	Response regulator, receiver
J6335_03545	COG4191	Histidine kinase
J6335_03550	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J6335_03605	COG1459	type II secretion system
J6335_03650	COG2188	Transcriptional regulator
J6335_03660	COG1609	Transcriptional regulator
J6335_03665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J6335_03670	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J6335_03680	COG0617	tRNA 3'-terminal CCA addition
J6335_03695	COG0525	valine-tRNA ligase activity
J6335_03710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J6335_03720	COG0795	lipopolysaccharide-transporting ATPase activity
J6335_03735	COG4974	Belongs to the 'phage' integrase family
J6335_03745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J6335_03750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J6335_03750	COG0047	phosphoribosylformylglycinamidine synthase activity
J6335_03755	COG5295	Hep Hag repeat protein
J6335_03760	COG1404	Belongs to the peptidase S8 family
J6335_03765	COG5295	Hep Hag repeat protein
J6335_03770	COG1404	Belongs to the peptidase S8 family
J6335_03775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J6335_03780	COG1459	type II secretion system
J6335_03785	COG2165	general secretion pathway protein
J6335_03790	COG4970	Tfp pilus assembly protein FimT
J6335_03795	COG2165	general secretion pathway protein
J6335_03800	COG4795	General secretion pathway protein
J6335_03805	COG3156	type II secretion system protein K
J6335_03810	COG3166	PFAM Fimbrial assembly family protein
J6335_03825	COG1450	Type ii and iii secretion system protein
J6335_03835	COG2188	Transcriptional regulator
J6335_03905	COG1215	transferase activity, transferring glycosyl groups
J6335_03910	COG1215	transferase activity, transferring glycosyl groups
J6335_03915	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
J6335_03940	COG0242	peptide deformylase activity
J6335_03945	COG0488	(ABC) transporter
J6335_03955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J6335_03960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J6335_03970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J6335_03970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J6335_03990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J6335_03995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J6335_04000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J6335_04015	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
J6335_04020	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
J6335_04030	COG2205	protein histidine kinase activity
J6335_04035	COG0745	RESPONSE REGULATOR receiver
J6335_04045	COG0277	FAD linked oxidase domain protein
J6335_04050	COG1988	membrane-bound metal-dependent
J6335_04055	COG0792	nuclease activity
J6335_04095	COG3116	cell division
J6335_04105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J6335_04110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J6335_04115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J6335_04125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J6335_04130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J6335_04135	COG1181	Belongs to the D-alanine--D-alanine ligase family
J6335_04140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J6335_04155	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J6335_04165	COG0739	heme binding
J6335_04170	COG0653	protein targeting
J6335_04175	COG0494	nUDIX hydrolase
J6335_04185	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J6335_04195	COG0604	alcohol dehydrogenase
J6335_04195	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_04195	COG3321	synthase
J6335_04210	COG0366	Alpha amylase catalytic
J6335_04245	COG2226	methyltransferase
J6335_04250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J6335_04260	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J6335_04300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J6335_04310	COG4106	trans-aconitate 2-methyltransferase activity
J6335_04315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J6335_04325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J6335_04330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J6335_04335	COG0667	Aldo Keto reductase
J6335_04345	COG4771	TonB-dependent receptor
J6335_04365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J6335_04370	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
J6335_04380	COG2175	clavaminate synthase activity
J6335_04390	COG4181	ATPase activity
J6335_04405	COG0642	Histidine kinase
J6335_04415	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J6335_04425	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
J6335_04435	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J6335_04440	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J6335_04455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J6335_04460	COG2967	ApaG domain
J6335_04465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J6335_04470	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J6335_04475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J6335_04480	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
J6335_04490	COG0123	including yeast histone deacetylase and acetoin utilization protein
J6335_04495	COG2096	Adenosyltransferase
J6335_04505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J6335_04510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J6335_04540	COG3384	dioxygenase
J6335_04545	COG0583	DNA-binding transcription factor activity
J6335_04550	COG0318	PFAM AMP-dependent synthetase and ligase
J6335_04560	COG1024	Enoyl-CoA hydratase
J6335_04580	COG3386	PFAM SMP-30 Gluconolaconase
J6335_04590	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
J6335_04615	COG0697	spore germination
J6335_04625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J6335_04650	COG2197	response regulator
J6335_04660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J6335_04675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J6335_04680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J6335_04685	COG0583	DNA-binding transcription factor activity
J6335_04690	COG3634	alkyl hydroperoxide reductase activity
J6335_04700	COG2890	protein-(glutamine-N5) methyltransferase activity
J6335_04720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J6335_04720	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J6335_04760	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J6335_04775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J6335_04780	COG1404	Belongs to the peptidase S8 family
J6335_04785	COG1404	Belongs to the peptidase S8 family
J6335_04790	COG1404	Belongs to the peptidase S8 family
J6335_04795	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J6335_04820	COG1295	ribonuclease BN
J6335_04825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J6335_04830	COG1254	Belongs to the acylphosphatase family
J6335_04845	COG0521	Mo-molybdopterin cofactor biosynthetic process
J6335_04855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J6335_04860	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J6335_04870	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J6335_04875	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J6335_04885	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J6335_04890	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J6335_04895	COG0193	aminoacyl-tRNA hydrolase activity
J6335_04900	COG0012	GTP binding
J6335_04920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J6335_04935	COG0250	Participates in transcription elongation, termination and antitermination
J6335_04940	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J6335_04945	COG0081	regulation of translation
J6335_04950	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J6335_04960	COG0085	RNA polymerase activity
J6335_04965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J6335_04970	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J6335_04975	COG0049	tRNA binding
J6335_04980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J6335_04985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J6335_05000	COG3328	transposase activity
J6335_05005	COG0051	transcription antitermination factor activity, RNA binding
J6335_05010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J6335_05015	COG0088	Forms part of the polypeptide exit tunnel
J6335_05020	COG0089	rRNA binding
J6335_05025	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J6335_05030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J6335_05040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J6335_05045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J6335_05050	COG0255	Belongs to the universal ribosomal protein uL29 family
J6335_05055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J6335_05065	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J6335_05070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J6335_05080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J6335_05085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J6335_05090	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J6335_05100	COG1841	ribosomal large subunit assembly
J6335_05105	COG0200	Binds to the 23S rRNA
J6335_05110	COG0201	protein transport
J6335_05135	COG0203	ribosomal protein L17
J6335_05140	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J6335_05160	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J6335_05170	COG0154	amidase activity
J6335_05180	COG1217	gtp-binding protein TYPA
J6335_05185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J6335_05190	COG0039	L-malate dehydrogenase activity
J6335_05195	COG0625	glutathione transferase activity
J6335_05210	COG0446	pyridine nucleotide-disulphide oxidoreductase
J6335_05210	COG1902	pentaerythritol trinitrate reductase activity
J6335_05215	COG0604	alcohol dehydrogenase
J6335_05220	COG3328	transposase activity
J6335_05225	COG3039	Transposase
J6335_05230	COG2885	chlorophyll binding
J6335_05250	COG0156	8-amino-7-oxononanoate synthase activity
J6335_05255	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
J6335_05260	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
J6335_05265	COG4208	sulfate ABC transporter
J6335_05270	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J6335_05280	COG3328	transposase activity
J6335_05305	COG0406	alpha-ribazole phosphatase activity
J6335_05315	COG0285	dihydrofolate synthase activity
J6335_05335	COG2833	Protein of unknown function (DUF455)
J6335_05350	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J6335_05355	COG0671	phosphoesterase, PA-phosphatase related
J6335_05360	COG0438	transferase activity, transferring glycosyl groups
J6335_05370	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J6335_05385	COG4783	chaperone-mediated protein folding
J6335_05400	COG0473	3-isopropylmalate dehydrogenase activity
J6335_05440	COG3328	transposase activity
J6335_05455	COG0544	peptidyl-prolyl cis-trans isomerase activity
J6335_05465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J6335_05495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J6335_05505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J6335_05515	COG0328	RNA-DNA hybrid ribonuclease activity
J6335_05520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J6335_05525	COG0631	protein serine/threonine phosphatase activity
J6335_05550	COG0859	PFAM glycosyl transferase family 9
J6335_05555	COG3642	lipopolysaccharide core region biosynthetic process
J6335_05560	COG1234	tRNA 3'-trailer cleavage
J6335_05565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J6335_05575	COG0315	cyclic pyranopterin monophosphate synthase activity
J6335_05580	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J6335_05585	COG0314	molybdopterin synthase activity
J6335_05605	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J6335_05610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J6335_05615	COG0537	adenosine 5'-monophosphoramidase activity
J6335_05635	COG0714	Associated with various cellular activities
J6335_05645	COG0424	maF-like protein
J6335_05650	COG1399	metal-binding, possibly nucleic acid-binding protein
J6335_05655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J6335_05660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J6335_05675	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_05690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J6335_05695	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J6335_05725	COG3829	transcription factor binding
J6335_05770	COG2373	Large extracellular alpha-helical protein
J6335_05790	COG3852	Histidine kinase
J6335_05795	COG4953	penicillin-binding protein 1C
J6335_05805	COG0678	peroxiredoxin activity
J6335_05825	COG0330	HflC and HflK could
J6335_05830	COG0330	HflC and HflK could
J6335_05840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J6335_05845	COG0308	aminopeptidase N
J6335_05855	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_05860	COG1309	transcriptional regulator
J6335_05885	COG3328	transposase activity
J6335_05915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J6335_05925	COG3387	PFAM Glycoside hydrolase 15-related
J6335_05930	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_05935	COG3537	Alpha-1,2-mannosidase
J6335_05955	COG0492	ferredoxin-NADP+ reductase activity
J6335_05985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J6335_05990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J6335_05995	COG2080	2 iron, 2 sulfur cluster binding
J6335_06030	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J6335_06065	COG1297	OPT oligopeptide transporter protein
J6335_06090	COG0823	Involved in the tonB-independent uptake of proteins
J6335_06090	COG1506	peptidase
J6335_06120	COG2207	Transcriptional regulator
J6335_06120	COG1917	Cupin 2, conserved barrel domain protein
J6335_06130	COG3328	transposase activity
J6335_06140	COG0753	catalase activity
J6335_06145	COG0656	L-ascorbic acid biosynthetic process
J6335_06155	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J6335_06155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J6335_06180	COG2814	Major facilitator Superfamily
J6335_06210	COG2194	sulfuric ester hydrolase activity
J6335_06225	COG0745	RESPONSE REGULATOR receiver
J6335_06230	COG0642	Histidine kinase
J6335_06240	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
J6335_06245	COG2894	cell division
J6335_06250	COG0850	regulation of cytokinetic process
J6335_06260	COG4585	Histidine kinase
J6335_06265	COG2197	response regulator
J6335_06280	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
J6335_06305	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
J6335_06315	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
J6335_06330	COG1595	DNA-templated transcription, initiation
J6335_06340	COG1946	Acyl-CoA thioesterase
J6335_06355	COG0824	Thioesterase
J6335_06360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J6335_06365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J6335_06370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J6335_06375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J6335_06380	COG0268	Binds directly to 16S ribosomal RNA
J6335_06390	COG0196	riboflavin kinase activity
J6335_06395	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J6335_06400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J6335_06405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J6335_06420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J6335_06425	COG1845	cytochrome c oxidase, subunit III
J6335_06430	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
J6335_06445	COG3152	Membrane
J6335_06455	COG2207	Transcriptional regulator
J6335_06460	COG0326	Molecular chaperone. Has ATPase activity
J6335_06470	COG1366	Belongs to the anti-sigma-factor antagonist family
J6335_06475	COG1366	Belongs to the anti-sigma-factor antagonist family
J6335_06505	COG4771	TonB-dependent receptor
J6335_06515	COG5507	3-demethylubiquinone-9 3-methyltransferase
J6335_06520	COG2205	protein histidine kinase activity
J6335_06530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J6335_06535	COG3437	response regulator, receiver
J6335_06535	COG3850	Histidine kinase
J6335_06535	COG4999	Histidine kinase
J6335_06535	COG2205	protein histidine kinase activity
J6335_06540	COG0784	Response regulator, receiver
J6335_06540	COG4191	Histidine kinase
J6335_06565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J6335_06575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J6335_06580	COG0228	four-way junction DNA binding
J6335_06585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J6335_06590	COG0336	Belongs to the RNA methyltransferase TrmD family
J6335_06595	COG0335	large ribosomal subunit rRNA binding
J6335_06600	COG0534	Mate efflux family protein
J6335_06625	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
J6335_06635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J6335_06675	COG3250	beta-galactosidase activity
J6335_06680	COG3867	Arabinogalactan endo-beta-1,4-galactanase
J6335_06700	COG1960	acyl-CoA dehydrogenase activity
J6335_06730	COG0457	Tetratricopeptide repeat
J6335_06740	COG0457	Tetratricopeptide repeat
J6335_06750	COG1024	Enoyl-CoA hydratase
J6335_06750	COG1250	3-hydroxyacyl-CoA dehydrogenase
J6335_06765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J6335_06770	COG0481	GTPase activity
J6335_06785	COG0571	ribonuclease III activity
J6335_06790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J6335_06795	COG1381	Involved in DNA repair and RecF pathway recombination
J6335_06805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J6335_06810	COG2954	triphosphatase activity
J6335_06815	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J6335_06820	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
J6335_06825	COG3046	protein related to deoxyribodipyrimidine photolyase
J6335_06830	COG1472	Belongs to the glycosyl hydrolase 3 family
J6335_06835	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
J6335_06840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J6335_06845	COG1278	Cold shock
J6335_06850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J6335_06860	COG1201	RNA secondary structure unwinding
J6335_06865	COG1793	dna ligase
J6335_06875	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J6335_06875	COG1793	dna ligase
J6335_06910	COG0183	Belongs to the thiolase family
J6335_06930	COG1451	nucleotide metabolic process
J6335_06935	COG5487	UPF0391 membrane protein
J6335_06945	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J6335_06965	COG1077	Cell shape determining protein MreB Mrl
J6335_06970	COG1047	Peptidyl-prolyl cis-trans
J6335_06980	COG2824	Alkylphosphonate utilization operon protein PhnA
J6335_06990	COG1902	pentaerythritol trinitrate reductase activity
J6335_06995	COG2814	Major facilitator Superfamily
J6335_07030	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J6335_07030	COG0392	lysyltransferase activity
J6335_07040	COG0251	oxidation-reduction process
J6335_07045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J6335_07060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J6335_07085	COG1595	DNA-templated transcription, initiation
J6335_07100	COG2878	Part of a membrane complex involved in electron transport
J6335_07110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J6335_07110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J6335_07130	COG0346	lactoylglutathione lyase activity
J6335_07145	COG0833	amino acid
J6335_07150	COG2040	homocysteine
J6335_07160	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J6335_07180	COG1695	Transcriptional regulator
J6335_07200	COG1981	membrane
J6335_07215	COG0825	malonyl-CoA metabolic process
J6335_07230	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J6335_07235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J6335_07240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J6335_07245	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J6335_07260	COG0750	zinc metalloprotease
J6335_07265	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J6335_07270	COG0575	Belongs to the CDS family
J6335_07275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J6335_07280	COG0233	cytoplasmic translational termination
J6335_07285	COG0528	UMP kinase activity
J6335_07295	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J6335_07300	COG0052	Belongs to the universal ribosomal protein uS2 family
J6335_07340	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
J6335_07350	COG1393	Belongs to the ArsC family
J6335_07355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J6335_07365	COG0367	asparagine synthase
J6335_07375	COG4774	siderophore transport
J6335_07475	COG1566	PFAM secretion protein HlyD family protein
J6335_07480	COG2814	Major facilitator Superfamily
J6335_07510	COG3104	oligopeptide transport
J6335_07540	COG0339	signal peptide processing
J6335_07545	COG0386	Belongs to the glutathione peroxidase family
J6335_07605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J6335_07610	COG0084	hydrolase, TatD family'
J6335_07625	COG1960	acyl-CoA dehydrogenase activity
J6335_07640	COG0367	asparagine synthase
J6335_07650	COG0305	Participates in initiation and elongation during chromosome replication
J6335_07655	COG0415	Belongs to the DNA photolyase family
J6335_07670	COG0583	DNA-binding transcription factor activity
J6335_07715	COG3706	GGDEF domain
J6335_07740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J6335_07755	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J6335_07765	COG0497	DNA recombination
J6335_07770	COG1420	regulation of RNA biosynthetic process
J6335_07775	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J6335_07780	COG0443	Heat shock 70 kDa protein
J6335_07785	COG0484	heat shock protein binding
J6335_07790	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
J6335_07820	COG0583	DNA-binding transcription factor activity
J6335_07825	COG1132	(ABC) transporter
J6335_07860	COG2850	peptidyl-arginine hydroxylation
J6335_07880	COG1253	flavin adenine dinucleotide binding
J6335_07910	COG1131	(ABC) transporter
J6335_07915	COG1725	Transcriptional regulator
J6335_07925	COG0386	Belongs to the glutathione peroxidase family
J6335_07940	COG2900	Belongs to the SlyX family
J6335_07970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J6335_07980	COG0646	methionine synthase
J6335_07980	COG1410	methionine synthase
J6335_07985	COG0646	methionine synthase
J6335_07985	COG1410	methionine synthase
J6335_07990	COG2226	methyltransferase
J6335_07995	COG1960	acyl-CoA dehydrogenase activity
J6335_08000	COG1960	acyl-CoA dehydrogenase activity
J6335_08015	COG0557	exoribonuclease II activity
J6335_08025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J6335_08035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J6335_08045	COG0704	Plays a role in the regulation of phosphate uptake
J6335_08050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J6335_08055	COG0581	inorganic phosphate transmembrane transporter activity
J6335_08060	COG0573	inorganic phosphate transmembrane transporter activity
J6335_08065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J6335_08090	COG0659	secondary active sulfate transmembrane transporter activity
J6335_08110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J6335_08110	COG4651	solute:proton antiporter activity
J6335_08140	COG0488	(ABC) transporter
J6335_08160	COG2755	lipolytic protein G-D-S-L family
J6335_08160	COG0657	acetylesterase activity
J6335_08180	COG0477	Major facilitator Superfamily
J6335_08195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J6335_08210	COG0217	transcriptional regulatory protein
J6335_08215	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J6335_08220	COG0632	four-way junction helicase activity
J6335_08225	COG3158	transport of potassium into the cell
J6335_08235	COG2255	four-way junction helicase activity
J6335_08240	COG0824	Thioesterase
J6335_08250	COG0848	biopolymer transport protein
J6335_08260	COG0823	Involved in the tonB-independent uptake of proteins
J6335_08265	COG2885	chlorophyll binding
J6335_08275	COG0602	queuosine metabolic process
J6335_08285	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J6335_08290	COG3920	Histidine kinase
J6335_08310	COG0840	transmembrane signaling receptor activity
J6335_08350	COG0514	ATP-dependent DNA helicase (RecQ)
J6335_08355	COG0783	Belongs to the Dps family
J6335_08360	COG1643	Atp-dependent helicase
J6335_08370	COG3328	transposase activity
J6335_08380	COG0837	glucose binding
J6335_08395	COG0535	radical SAM domain protein
J6335_08400	COG0535	radical SAM domain protein
J6335_08405	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
J6335_08410	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J6335_08420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J6335_08430	COG1215	transferase activity, transferring glycosyl groups
J6335_08435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J6335_08445	COG1199	ATP-dependent helicase activity
J6335_08455	COG1397	ADP-ribosylglycohydrolase
J6335_08465	COG0189	ligase activity
J6335_08480	COG0835	chemotaxis
J6335_08485	COG0840	transmembrane signaling receptor activity
J6335_08490	COG0784	Response regulator, receiver
J6335_08490	COG0643	Histidine kinase
J6335_08490	COG2198	Histidine kinase
J6335_08515	COG1446	asparaginase
J6335_08520	COG3142	Participates in the control of copper homeostasis
J6335_08555	COG3537	Alpha-1,2-mannosidase
J6335_08565	COG1472	Belongs to the glycosyl hydrolase 3 family
J6335_08575	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J6335_08580	COG1388	LysM domain
J6335_08580	COG3858	chitin binding
J6335_08600	COG4787	bacterial-type flagellum-dependent cell motility
J6335_08610	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
J6335_08615	COG1558	bacterial-type flagellum-dependent cell motility
J6335_08625	COG0835	chemotaxis
J6335_08625	COG0784	Response regulator, receiver
J6335_08645	COG5002	protein histidine kinase activity
J6335_08655	COG4585	Histidine kinase
J6335_08675	COG2915	High frequency lysogenization protein hflD homolog
J6335_08680	COG0482	sulfurtransferase activity
J6335_08700	COG0542	response to heat
J6335_08710	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J6335_08720	COG0492	ferredoxin-NADP+ reductase activity
J6335_08725	COG1674	ftsk spoiiie
J6335_08735	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J6335_08745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J6335_08750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J6335_08755	COG0183	Belongs to the thiolase family
J6335_08760	COG1250	3-hydroxyacyl-CoA dehydrogenase
J6335_08760	COG1024	Enoyl-CoA hydratase
J6335_08775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J6335_08795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J6335_08800	COG1160	GTP binding
J6335_08805	COG0303	'Molybdopterin
J6335_08810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J6335_08845	COG0708	Exodeoxyribonuclease III
J6335_08855	COG0303	'Molybdopterin
J6335_08860	COG0746	molybdenum cofactor guanylyltransferase activity
J6335_08885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J6335_08885	COG1648	precorrin-2 dehydrogenase activity
J6335_08895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J6335_08900	COG2223	nitrite transmembrane transporter activity
J6335_08905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J6335_08915	COG0243	molybdopterin cofactor binding
J6335_08935	COG3685	Protein conserved in bacteria
J6335_08955	COG5001	Diguanylate cyclase
J6335_08965	COG4566	intracellular signal transduction
J6335_09015	COG3328	transposase activity
J6335_09030	COG3039	Transposase
J6335_09035	COG3328	transposase activity
J6335_09115	COG3328	transposase activity
J6335_09125	COG1073	alpha beta
J6335_09125	COG2226	methyltransferase
J6335_09140	COG0363	glucosamine-6-phosphate deaminase activity
J6335_09235	COG3328	transposase activity
J6335_09280	COG3328	transposase activity
J6335_09300	COG1192	Involved in chromosome partitioning
J6335_09345	COG3318	Belongs to the UPF0149 family
J6335_09345	COG3012	SEC-C Motif Domain Protein
J6335_09380	COG3328	transposase activity
J6335_09415	COG1309	transcriptional regulator
J6335_09430	COG2154	pterin-4-alpha-carbinolamine dehydratase
J6335_09440	COG0428	transporter
J6335_09445	COG3064	Membrane
J6335_09455	COG1530	ribonuclease E activity
J6335_09460	COG3039	Transposase
J6335_09470	COG1054	Belongs to the UPF0176 family
J6335_09490	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J6335_09515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J6335_09520	COG0322	excinuclease ABC activity
J6335_09530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J6335_09535	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J6335_09540	COG1663	tetraacyldisaccharide 4'-kinase activity
J6335_09545	COG1132	(ABC) transporter
J6335_09555	COG0811	peptide transport
J6335_09570	COG1136	(ABC) transporter
J6335_09575	COG4591	ABC-type transport system involved in lipoprotein release permease component
J6335_09585	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
J6335_09590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J6335_09605	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
J6335_09620	COG0354	folic acid binding
J6335_09630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J6335_09635	COG0837	glucose binding
J6335_09640	COG0363	glucosamine-6-phosphate deaminase activity
J6335_09645	COG0129	dihydroxy-acid dehydratase activity
J6335_09650	COG0800	Aldolase
J6335_09715	COG2205	protein histidine kinase activity
J6335_09715	COG0784	Response regulator, receiver
J6335_09720	COG2183	response to ionizing radiation
J6335_09730	COG0723	plastoquinol--plastocyanin reductase activity
J6335_09730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J6335_09745	COG3243	poly(R)-hydroxyalkanoic acid synthase
J6335_09755	COG1183	phosphatidylcholine synthase activity
J6335_09760	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_09775	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J6335_09790	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
J6335_09805	COG1914	H( )-stimulated, divalent metal cation uptake system
J6335_09825	COG2814	Major facilitator Superfamily
J6335_09840	COG1335	isochorismatase
J6335_09855	COG2197	response regulator
J6335_09880	COG0583	DNA-binding transcription factor activity
J6335_09885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J6335_09890	COG3002	Belongs to the UPF0753 family
J6335_09900	COG0604	alcohol dehydrogenase
J6335_09905	COG3384	dioxygenase
J6335_09920	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J6335_09960	COG0519	Catalyzes the synthesis of GMP from XMP
J6335_09960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J6335_09970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J6335_09980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J6335_09980	COG0475	glutathione-regulated potassium exporter activity
J6335_09985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J6335_09995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J6335_10000	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
J6335_10010	COG0776	regulation of translation
J6335_10015	COG0539	negative regulation of cytoplasmic translation
J6335_10020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J6335_10035	COG2957	Belongs to the agmatine deiminase family
J6335_10040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J6335_10065	COG0395	ABC-type sugar transport system, permease component
J6335_10070	COG1175	transmembrane transport
J6335_10100	COG2350	Protein conserved in bacteria
J6335_10105	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J6335_10110	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J6335_10115	COG1187	pseudouridine synthase activity
J6335_10130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J6335_10135	COG0436	Aminotransferase
J6335_10140	COG4133	protoheme IX ABC transporter activity
J6335_10160	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J6335_10185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J6335_10195	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J6335_10200	COG4988	ABC transporter
J6335_10210	COG1294	oxidase, subunit
J6335_10240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J6335_10245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J6335_10255	COG0165	Argininosuccinate lyase
J6335_10260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J6335_10270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J6335_10275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J6335_10285	COG0137	argininosuccinate synthase activity
J6335_10290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J6335_10300	COG0215	cysteine-tRNA ligase activity
J6335_10305	COG2166	iron-sulfur cluster assembly
J6335_10320	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J6335_10325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J6335_10350	COG4302	ethanolamine ammonia-lyase activity
J6335_10380	COG3039	Transposase
J6335_10410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J6335_10415	COG0402	S-adenosylhomocysteine deaminase activity
J6335_10425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J6335_10430	COG1509	lysine 2,3-aminomutase activity
J6335_10435	COG3300	MHYT domain
J6335_10435	COG5001	Diguanylate cyclase
J6335_10450	COG0483	inositol monophosphate 1-phosphatase activity
J6335_10455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J6335_10470	COG0488	(ABC) transporter
J6335_10475	COG0513	Belongs to the DEAD box helicase family
J6335_10480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J6335_10485	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J6335_10500	COG0625	glutathione transferase activity
J6335_10510	COG4681	YaeQ
J6335_10515	COG2081	HI0933 family
J6335_10525	COG0501	Belongs to the peptidase M48B family
J6335_10530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J6335_10535	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_10560	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J6335_10565	COG0860	N-Acetylmuramoyl-L-alanine amidase
J6335_10570	COG0802	atpase or kinase
J6335_10575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J6335_10575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J6335_10580	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J6335_10585	COG1570	exodeoxyribonuclease VII activity
J6335_10595	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J6335_10640	COG0835	chemotaxis
J6335_10645	COG0840	transmembrane signaling receptor activity
J6335_10650	COG2094	Belongs to the DNA glycosylase MPG family
J6335_10655	COG1201	RNA secondary structure unwinding
J6335_10675	COG2969	positive regulation of protein catabolic process
J6335_10680	COG0625	glutathione transferase activity
J6335_10685	COG2857	Cytochrome c1
J6335_10690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J6335_10695	COG0723	plastoquinol--plastocyanin reductase activity
J6335_10700	COG0741	lytic transglycosylase activity
J6335_10715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J6335_10720	COG1702	phosphate starvation-inducible protein PhoH
J6335_10730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J6335_10740	COG4535	Mg2 and Co2 transporter CorC
J6335_10755	COG1012	belongs to the aldehyde dehydrogenase family
J6335_10760	COG1177	transmembrane transport
J6335_10765	COG1176	ABC-type spermidine putrescine transport system, permease component I
J6335_10770	COG3842	ATPase activity
J6335_10790	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J6335_10810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J6335_10815	COG0174	glutamine synthetase
J6335_10820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J6335_10830	COG2703	oxygen carrier activity
J6335_10835	COG0477	Major facilitator Superfamily
J6335_10845	COG0243	molybdopterin cofactor binding
J6335_10850	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J6335_10855	COG2223	nitrite transmembrane transporter activity
J6335_10860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J6335_10870	COG2733	membrane
J6335_10875	COG0784	Response regulator, receiver
J6335_10875	COG2205	protein histidine kinase activity
J6335_10875	COG5002	protein histidine kinase activity
J6335_10885	COG0477	Major facilitator Superfamily
J6335_10920	COG2902	Dehydrogenase
J6335_10930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J6335_10935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J6335_10940	COG1609	Transcriptional regulator
J6335_10945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J6335_10945	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J6335_10950	COG1105	Belongs to the carbohydrate kinase PfkB family
J6335_10955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J6335_10955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J6335_10970	COG3328	transposase activity
J6335_10975	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J6335_10985	COG1862	Preprotein translocase
J6335_10990	COG0343	queuine tRNA-ribosyltransferase activity
J6335_10995	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J6335_11030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J6335_11035	COG3291	Pkd domain containing protein
J6335_11040	COG0405	Gamma-glutamyltransferase
J6335_11045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J6335_11055	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J6335_11060	COG0742	ribosomal rna small subunit methyltransferase
J6335_11065	COG0326	Molecular chaperone. Has ATPase activity
J6335_11150	COG3702	type iv secretory pathway
J6335_11170	COG2948	multi-organism process
J6335_11190	COG3505	Type IV secretory pathway VirD4
J6335_11205	COG0556	nucleotide-excision repair
J6335_11375	COG3179	chitinase
J6335_11420	COG4695	Portal protein
J6335_11495	COG3275	phosphorelay sensor kinase activity
J6335_11500	COG1611	Belongs to the LOG family
J6335_11510	COG2095	MarC family integral membrane protein
J6335_11520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J6335_11555	COG1185	polyribonucleotide nucleotidyltransferase activity
J6335_11560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J6335_11565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J6335_11570	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J6335_11575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J6335_11580	COG0195	Participates in both transcription termination and antitermination
J6335_11585	COG0779	Required for maturation of 30S ribosomal subunits
J6335_11595	COG1007	ATP synthesis coupled electron transport
J6335_11620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J6335_11625	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J6335_11635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J6335_11640	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
J6335_11645	COG0649	NAD binding
J6335_11650	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J6335_11655	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J6335_11660	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J6335_11675	COG0149	triose-phosphate isomerase activity
J6335_11680	COG4221	oxidoreductase activity
J6335_11710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J6335_11715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
J6335_11720	COG0159	tryptophan synthase activity
J6335_11730	COG0133	tryptophan synthase activity
J6335_11740	COG0135	phosphoribosylanthranilate isomerase activity
J6335_11745	COG0101	tRNA pseudouridine synthase activity
J6335_11760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J6335_11765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J6335_11770	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J6335_11775	COG2890	protein-(glutamine-N5) methyltransferase activity
J6335_11785	COG0688	phosphatidylethanolamine metabolic process
J6335_11795	COG0433	COG0433 Predicted ATPase
J6335_11820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J6335_11825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J6335_11850	COG0717	Belongs to the dCTP deaminase family
J6335_11855	COG0489	protein tyrosine kinase activity
J6335_11885	COG3590	peptidase
J6335_11910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J6335_11915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J6335_11920	COG2311	Membrane
J6335_11925	COG1047	Peptidyl-prolyl cis-trans
J6335_11930	COG0791	NLP P60 protein
J6335_11935	COG0791	NLP P60 protein
J6335_11945	COG4106	trans-aconitate 2-methyltransferase activity
J6335_11950	COG1301	dicarboxylic acid transport
J6335_11955	COG1785	Belongs to the alkaline phosphatase family
J6335_11960	COG0037	tRNA processing
J6335_11965	COG1722	exodeoxyribonuclease VII activity
J6335_11970	COG0142	geranyltranstransferase activity
J6335_11975	COG4104	PAAR repeat-containing protein
J6335_11985	COG0312	modulator of DNA gyrase
J6335_11990	COG3028	Belongs to the UPF0307 family
J6335_11995	COG0312	modulator of DNA gyrase
J6335_12005	COG3164	Protein of unknown function
J6335_12015	COG0424	maF-like protein
J6335_12020	COG2968	Membrane
J6335_12035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J6335_12050	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J6335_12065	COG0495	leucyl-tRNA aminoacylation
J6335_12075	COG3118	belongs to the thioredoxin family
J6335_12100	COG2155	Conserved Protein
J6335_12150	COG1132	(ABC) transporter
J6335_12180	COG0745	RESPONSE REGULATOR receiver
J6335_12185	COG5000	phosphorelay sensor kinase activity
J6335_12185	COG5002	protein histidine kinase activity
J6335_12190	COG0475	glutathione-regulated potassium exporter activity
J6335_12200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J6335_12220	COG1187	pseudouridine synthase activity
J6335_12225	COG5002	protein histidine kinase activity
J6335_12225	COG5001	Diguanylate cyclase
J6335_12235	COG1595	DNA-templated transcription, initiation
J6335_12350	COG0667	Aldo Keto reductase
J6335_12355	COG2814	Major facilitator Superfamily
J6335_12360	COG0583	DNA-binding transcription factor activity
J6335_12370	COG2207	Transcriptional regulator
J6335_12380	COG1309	transcriptional regulator
J6335_12390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J6335_12405	COG0735	belongs to the Fur family
J6335_12410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J6335_12435	COG4452	Inner membrane protein CreD
J6335_12455	COG0745	RESPONSE REGULATOR receiver
J6335_12460	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J6335_12475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J6335_12485	COG0643	Histidine kinase
J6335_12485	COG2198	Histidine kinase
J6335_12490	COG0840	transmembrane signaling receptor activity
J6335_12495	COG0835	chemotaxis
J6335_12500	COG2202	Pas domain
J6335_12500	COG2200	EAL domain
J6335_12500	COG2199	diguanylate cyclase activity
J6335_12505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J6335_12510	COG2201	protein-glutamate methylesterase activity
J6335_12520	COG3590	peptidase
J6335_12535	COG1515	deoxyribonuclease V activity
J6335_12545	COG1741	Belongs to the pirin family
J6335_12560	COG1741	Belongs to the pirin family
J6335_12565	COG1966	Carbon starvation protein
J6335_12570	COG2879	small protein
J6335_12605	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J6335_12610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J6335_12615	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J6335_12620	COG2080	2 iron, 2 sulfur cluster binding
J6335_12625	COG3321	synthase
J6335_12625	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_12625	COG0604	alcohol dehydrogenase
J6335_12630	COG2203	Gaf domain
J6335_12630	COG3706	GGDEF domain
J6335_12630	COG4251	negative regulation of phosphorylation
J6335_12630	COG5001	Diguanylate cyclase
J6335_12635	COG0629	single-stranded DNA binding
J6335_12640	COG0142	geranyltranstransferase activity
J6335_12650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J6335_12665	COG0527	aspartate kinase activity
J6335_12670	COG0384	phenazine biosynthesis protein PhzF
J6335_12675	COG0384	phenazine biosynthesis protein PhzF
J6335_12685	COG1764	response to oxidative stress
J6335_12690	COG0540	Belongs to the ATCase OTCase family
J6335_12695	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J6335_12700	COG1678	Uncharacterized ACR, COG1678
J6335_12705	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
J6335_12710	COG0519	Catalyzes the synthesis of GMP from XMP
J6335_12735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J6335_12750	COG0739	heme binding
J6335_12770	COG0693	protein deglycase activity
J6335_12780	COG1959	2 iron, 2 sulfur cluster binding
J6335_12785	COG0719	Fe-S assembly protein
J6335_12790	COG0396	ATPase activity
J6335_12795	COG0719	Fe-S assembly protein
J6335_12800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J6335_12805	COG0456	acetyltransferase
J6335_12810	COG2146	nitrite reductase [NAD(P)H] activity
J6335_12815	COG4774	siderophore transport
J6335_12820	COG3128	pkhd-type hydroxylase
J6335_12845	COG3328	transposase activity
J6335_12850	COG1477	protein flavinylation
J6335_12855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J6335_12865	COG1555	photosystem II stabilization
J6335_12885	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J6335_12895	COG0628	permease
J6335_12905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J6335_12920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J6335_12940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J6335_12945	COG0271	Belongs to the BolA IbaG family
J6335_12955	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J6335_12965	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J6335_12970	COG1137	ATPase activity
J6335_12985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J6335_12990	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
J6335_12995	COG1660	Displays ATPase and GTPase activities
J6335_13005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J6335_13020	COG2239	Acts as a magnesium transporter
J6335_13030	COG1294	oxidase, subunit
J6335_13080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J6335_13080	COG0551	DNA topoisomerase type I activity
J6335_13095	COG2951	lytic endotransglycosylase activity
J6335_13170	COG1113	amino acid transport
J6335_13195	COG2197	response regulator
J6335_13200	COG0531	amino acid
J6335_13270	COG2814	Major facilitator Superfamily
J6335_13275	COG0754	glutathionylspermidine amidase activity
J6335_13300	COG1842	Phage shock protein A
J6335_13310	COG0259	pyridoxamine-phosphate oxidase activity
J6335_13315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J6335_13320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J6335_13330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J6335_13335	COG2814	Major facilitator Superfamily
J6335_13360	COG0784	Response regulator, receiver
J6335_13360	COG2198	Histidine kinase
J6335_13360	COG2205	protein histidine kinase activity
J6335_13365	COG2353	YceI-like domain
J6335_13385	COG1760	l-serine dehydratase
J6335_13395	COG0460	homoserine dehydrogenase
J6335_13395	COG0527	aspartate kinase activity
J6335_13400	COG0626	cystathionine gamma-synthase activity
J6335_13405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J6335_13410	COG0739	heme binding
J6335_13415	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J6335_13420	COG1272	protein, Hemolysin III
J6335_13425	COG2982	Protein involved in outer membrane biogenesis
J6335_13430	COG0517	IMP dehydrogenase activity
J6335_13430	COG0516	GMP reductase activity
J6335_13435	COG0463	Glycosyl transferase, family 2
J6335_13440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J6335_13445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J6335_13455	COG4771	TonB-dependent receptor
J6335_13460	COG1309	transcriptional regulator
J6335_13470	COG1960	acyl-CoA dehydrogenase activity
J6335_13495	COG3328	transposase activity
J6335_13520	COG0509	glycine decarboxylation via glycine cleavage system
J6335_13525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J6335_13535	COG0330	HflC and HflK could
J6335_13540	COG1742	UPF0060 membrane protein
J6335_13545	COG3956	TIGRFAM MazG family protein
J6335_13555	COG0494	nUDIX hydrolase
J6335_13565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J6335_13570	COG0837	glucose binding
J6335_13610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
J6335_13615	COG1360	Flagellar Motor Protein
J6335_13620	COG1192	Involved in chromosome partitioning
J6335_13625	COG0835	chemotaxis
J6335_13635	COG0745	RESPONSE REGULATOR receiver
J6335_13645	COG0840	transmembrane signaling receptor activity
J6335_13650	COG0840	transmembrane signaling receptor activity
J6335_13665	COG0840	transmembrane signaling receptor activity
J6335_13675	COG0840	transmembrane signaling receptor activity
J6335_13680	COG0840	transmembrane signaling receptor activity
J6335_13685	COG0840	transmembrane signaling receptor activity
J6335_13690	COG0840	transmembrane signaling receptor activity
J6335_13705	COG0840	transmembrane signaling receptor activity
J6335_13710	COG0840	transmembrane signaling receptor activity
J6335_13715	COG0840	transmembrane signaling receptor activity
J6335_13720	COG0840	transmembrane signaling receptor activity
J6335_13725	COG0840	transmembrane signaling receptor activity
J6335_13735	COG0835	chemotaxis
J6335_13745	COG0840	transmembrane signaling receptor activity
J6335_13755	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
J6335_13760	COG2201	protein-glutamate methylesterase activity
J6335_13770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J6335_13805	COG0318	PFAM AMP-dependent synthetase and ligase
J6335_13810	COG1024	Enoyl-CoA hydratase
J6335_13815	COG2205	protein histidine kinase activity
J6335_13815	COG2198	Histidine kinase
J6335_13815	COG0784	Response regulator, receiver
J6335_13820	COG2205	protein histidine kinase activity
J6335_13820	COG2198	Histidine kinase
J6335_13820	COG0784	Response regulator, receiver
J6335_13830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J6335_13850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J6335_13860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J6335_13865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J6335_13875	COG0505	Belongs to the CarA family
J6335_13880	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J6335_13885	COG2258	MOSC domain
J6335_13890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J6335_13935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J6335_13955	COG0277	FAD linked oxidase domain protein
J6335_13960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J6335_13970	COG0531	amino acid
J6335_13975	COG0531	amino acid
J6335_13980	COG0235	Class ii aldolase
J6335_13985	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
J6335_13990	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
J6335_14005	COG0140	phosphoribosyl-ATP diphosphatase activity
J6335_14005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J6335_14010	COG0107	imidazoleglycerol-phosphate synthase activity
J6335_14015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J6335_14020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J6335_14025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J6335_14025	COG0131	Imidazoleglycerol-phosphate dehydratase
J6335_14030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J6335_14035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J6335_14040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J6335_14050	COG0124	histidyl-tRNA synthetase
J6335_14055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J6335_14090	COG0460	homoserine dehydrogenase
J6335_14090	COG0527	aspartate kinase activity
J6335_14095	COG3328	transposase activity
J6335_14100	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
J6335_14120	COG3328	transposase activity
J6335_14155	COG3328	transposase activity
J6335_14250	COG0531	amino acid
J6335_14265	COG0006	proline dipeptidase activity
J6335_14275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J6335_14290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J6335_14295	COG3938	Belongs to the proline racemase family
J6335_14305	COG0552	protein localization to endoplasmic reticulum
J6335_14310	COG1194	a g-specific adenine glycosylase
J6335_14330	COG4191	Histidine kinase
J6335_14330	COG0784	Response regulator, receiver
J6335_14345	COG0322	excinuclease ABC activity
J6335_14360	COG3040	lipid binding
J6335_14370	COG1960	acyl-CoA dehydrogenase activity
J6335_14380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J6335_14400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J6335_14410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J6335_14435	COG0438	transferase activity, transferring glycosyl groups
J6335_14445	COG0438	transferase activity, transferring glycosyl groups
J6335_14450	COG0438	transferase activity, transferring glycosyl groups
J6335_14500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J6335_14500	COG0072	phenylalanine-tRNA ligase activity
J6335_14505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J6335_14520	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J6335_14525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J6335_14540	COG2211	Major facilitator Superfamily
J6335_14550	COG1082	Xylose isomerase domain protein TIM barrel
J6335_14570	COG0366	Alpha amylase catalytic
J6335_14575	COG3328	transposase activity
J6335_14585	COG1012	belongs to the aldehyde dehydrogenase family
J6335_14600	COG0167	dihydroorotate dehydrogenase activity
J6335_14605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J6335_14610	COG0697	spore germination
J6335_14625	COG0671	phosphoesterase, PA-phosphatase related
J6335_14630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J6335_14640	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
J6335_14645	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
J6335_14650	COG2203	Gaf domain
J6335_14650	COG3706	GGDEF domain
J6335_14650	COG4251	negative regulation of phosphorylation
J6335_14650	COG5001	Diguanylate cyclase
J6335_14660	COG1472	Belongs to the glycosyl hydrolase 3 family
J6335_14680	COG0166	Belongs to the GPI family
J6335_14685	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J6335_14690	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J6335_14695	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J6335_14720	COG1469	GTP cyclohydrolase I activity
J6335_14725	COG0860	N-Acetylmuramoyl-L-alanine amidase
J6335_14745	COG0477	Major facilitator Superfamily
J6335_14750	COG2115	Belongs to the xylose isomerase family
J6335_14755	COG1070	Carbohydrate kinase
J6335_14765	COG1501	Belongs to the glycosyl hydrolase 31 family
J6335_14810	COG0800	Aldolase
J6335_14815	COG4948	Mandelate Racemase Muconate Lactonizing
J6335_14825	COG3734	2-keto-3-deoxy-galactonokinase
J6335_14830	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J6335_14840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J6335_14855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J6335_14860	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J6335_14875	COG0351	phosphomethylpyrimidine kinase
J6335_14900	COG0583	DNA-binding transcription factor activity
J6335_14920	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
J6335_14925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J6335_14930	COG2137	regulation of response to DNA damage stimulus
J6335_14935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J6335_14940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J6335_14950	COG1546	Belongs to the CinA family
J6335_14955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J6335_14965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J6335_14970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J6335_14980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
J6335_14985	COG1534	Rna-binding protein
J6335_14990	COG3737	Protein of unknown function (DUF498/DUF598)
J6335_15000	COG1238	metal cluster binding
J6335_15005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J6335_15010	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J6335_15015	COG2840	Smr protein MutS2
J6335_15020	COG0585	pseudouridine synthase activity
J6335_15025	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J6335_15035	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
J6335_15040	COG0148	phosphopyruvate hydratase activity
J6335_15050	COG2877	3-deoxy-8-phosphooctulonate synthase activity
J6335_15055	COG0504	CTP synthase activity
J6335_15080	COG0306	phosphate transporter
J6335_15090	COG1253	flavin adenine dinucleotide binding
J6335_15105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J6335_15110	COG0477	Major facilitator Superfamily
J6335_15120	COG1136	(ABC) transporter
J6335_15145	COG2264	protein methyltransferase activity
J6335_15175	COG2244	polysaccharide biosynthetic process
J6335_15225	COG1595	DNA-templated transcription, initiation
J6335_15240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J6335_15250	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J6335_15260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J6335_15280	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
J6335_15285	COG0784	Response regulator, receiver
J6335_15285	COG4191	Histidine kinase
J6335_15305	COG0840	transmembrane signaling receptor activity
J6335_15330	COG0583	DNA-binding transcription factor activity
J6335_15335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J6335_15340	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J6335_15355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J6335_15360	COG0077	Prephenate dehydratase
J6335_15360	COG1605	Chorismate mutase
J6335_15365	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J6335_15370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J6335_15375	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
J6335_15415	COG1228	amidohydrolase
J6335_15420	COG2986	histidine ammonia-lyase
J6335_15430	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J6335_15440	COG4993	Dehydrogenase
J6335_15450	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
J6335_15460	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
J6335_15465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J6335_15470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J6335_15480	COG3115	cell septum assembly
J6335_15490	COG0359	binds to the 23S rRNA
J6335_15495	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J6335_15500	COG0360	Binds together with S18 to 16S ribosomal RNA
J6335_15505	COG0316	Belongs to the HesB IscA family
J6335_15510	COG0017	Asparaginyl-tRNA synthetase
J6335_15590	COG0288	reversible hydration of carbon dioxide
J6335_15595	COG0662	Cupin 2, conserved barrel domain protein
J6335_15605	COG3844	kynureninase activity
J6335_15610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J6335_15620	COG2925	Exonuclease
J6335_15640	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J6335_15645	COG0116	Belongs to the methyltransferase superfamily
J6335_15645	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J6335_15655	COG0488	(ABC) transporter
J6335_15690	COG0494	nUDIX hydrolase
J6335_15700	COG1024	Enoyl-CoA hydratase
J6335_15710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J6335_15725	COG4772	TonB-dependent receptor
J6335_15735	COG4264	IucA IucC family
J6335_15750	COG0019	diaminopimelate decarboxylase activity
J6335_15780	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J6335_15790	COG1492	cobalamin metabolic process
J6335_15800	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J6335_15825	COG4206	TonB-dependent receptor
J6335_15835	COG0542	response to heat
J6335_15880	COG1877	trehalose-phosphatase activity
J6335_15885	COG3387	PFAM Glycoside hydrolase 15-related
J6335_15905	COG3328	transposase activity
J6335_15915	COG0840	transmembrane signaling receptor activity
J6335_15920	COG3011	Protein conserved in bacteria
J6335_15935	COG0564	pseudouridine synthase activity
J6335_15940	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J6335_15950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J6335_15950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J6335_15965	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J6335_15970	COG0045	succinate-CoA ligase (ADP-forming) activity
J6335_16010	COG3328	transposase activity
J6335_16020	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
J6335_16025	COG0237	dephospho-CoA kinase activity
J6335_16050	COG0745	RESPONSE REGULATOR receiver
J6335_16060	COG0189	ligase activity
J6335_16075	COG3328	transposase activity
J6335_16100	COG2003	Belongs to the UPF0758 family
J6335_16125	COG3328	transposase activity
J6335_16170	COG2022	thiamine diphosphate biosynthetic process
J6335_16175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J6335_16180	COG0471	metal ion transport
J6335_16180	COG3273	potassium ion transport
J6335_16205	COG1970	mechanosensitive ion channel activity
J6335_16215	COG1609	Transcriptional regulator
J6335_16225	COG3250	beta-galactosidase activity
J6335_16230	COG4948	Mandelate Racemase Muconate Lactonizing
J6335_16240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J6335_16250	COG0308	aminopeptidase N
J6335_16255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J6335_16265	COG2895	sulfate adenylyltransferase (ATP) activity
J6335_16265	COG0529	Catalyzes the synthesis of activated sulfate
J6335_16270	COG0175	sulfate reduction
J6335_16275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J6335_16280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J6335_16285	COG0175	sulfate reduction
J6335_16305	COG2205	protein histidine kinase activity
J6335_16305	COG2198	Histidine kinase
J6335_16305	COG0784	Response regulator, receiver
J6335_16320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J6335_16320	COG1648	precorrin-2 dehydrogenase activity
J6335_16335	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
J6335_16340	COG3588	fructose-bisphosphate aldolase
J6335_16345	COG0469	pyruvate kinase activity
J6335_16355	COG0126	phosphoglycerate kinase activity
J6335_16385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J6335_16395	COG3047	cAMP biosynthetic process
J6335_16410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J6335_16410	COG3453	Protein conserved in bacteria
J6335_16415	COG0725	ABC transporter, periplasmic molybdate-binding protein
J6335_16420	COG4149	molybdate abc transporter
J6335_16425	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J6335_16445	COG0642	Histidine kinase
J6335_16470	COG1022	Amp-dependent synthetase and ligase
J6335_16495	COG1376	ErfK ybiS ycfS ynhG family protein
J6335_16500	COG0739	heme binding
J6335_16505	COG4773	Receptor
J6335_16520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J6335_16525	COG1301	dicarboxylic acid transport
J6335_16535	COG2304	oxidoreductase activity
J6335_16555	COG0714	Associated with various cellular activities
J6335_16585	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J6335_16605	COG1957	nucleoside hydrolase
J6335_16610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J6335_16620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J6335_16635	COG1561	YicC-like family, N-terminal region
J6335_16640	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J6335_16650	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J6335_16655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J6335_16670	COG0006	proline dipeptidase activity
J6335_16680	COG0006	proline dipeptidase activity
J6335_16685	COG3079	Belongs to the UPF0149 family
J6335_16705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J6335_16725	COG2912	Transglutaminase-like superfamily
J6335_16730	COG1773	rubredoxin
J6335_16735	COG0352	thiamine-phosphate diphosphorylase activity
J6335_16755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J6335_16765	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
J6335_16770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J6335_16800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J6335_16805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J6335_16810	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_16820	COG0671	phosphoesterase, PA-phosphatase related
J6335_16825	COG3781	membrane
J6335_16835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J6335_16840	COG0563	adenylate kinase activity
J6335_16855	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J6335_16865	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J6335_16885	COG3710	Transcriptional regulator
J6335_16890	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J6335_16900	COG0840	transmembrane signaling receptor activity
J6335_16905	COG0405	Gamma-glutamyltransferase
J6335_16910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J6335_16930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J6335_16935	COG0473	3-isopropylmalate dehydrogenase activity
J6335_16940	COG0066	3-isopropylmalate dehydratase activity
J6335_16945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J6335_16965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J6335_16970	COG1538	Outer membrane efflux protein
J6335_16975	COG1519	Transferase
J6335_16980	COG1560	Kdo2-lipid A biosynthetic process
J6335_17005	COG0281	malic enzyme
J6335_17005	COG0280	phosphate acetyltransferase
J6335_17010	COG1301	dicarboxylic acid transport
J6335_17035	COG0583	DNA-binding transcription factor activity
J6335_17040	COG0667	Aldo Keto reductase
J6335_17055	COG2197	response regulator
J6335_17065	COG0642	Histidine kinase
J6335_17080	COG2851	Citrate transporter
J6335_17085	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_17090	COG1609	Transcriptional regulator
J6335_17095	COG2211	Major facilitator Superfamily
J6335_17120	COG1162	GTPase activity
J6335_17125	COG0436	Aminotransferase
J6335_17140	COG0726	polysaccharide deacetylase
J6335_17145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J6335_17160	COG3964	amidohydrolase
J6335_17165	COG0402	S-adenosylhomocysteine deaminase activity
J6335_17190	COG3328	transposase activity
J6335_17200	COG1307	EDD domain protein, DegV family
J6335_17220	COG3791	Glutathione-dependent formaldehyde-activating
J6335_17250	COG2205	protein histidine kinase activity
J6335_17265	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J6335_17280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J6335_17290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J6335_17295	COG1012	belongs to the aldehyde dehydrogenase family
J6335_17300	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
J6335_17325	COG1183	phosphatidylcholine synthase activity
J6335_17335	COG0442	prolyl-tRNA aminoacylation
J6335_17350	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J6335_17355	COG1127	ABC transporter
J6335_17360	COG3218	ABC-type transport auxiliary lipoprotein component
J6335_17360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J6335_17390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J6335_17395	COG0662	Cupin 2, conserved barrel domain protein
J6335_17395	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
J6335_17425	COG2086	electron transfer activity
J6335_17440	COG0546	phosphoglycolate phosphatase activity
J6335_17440	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J6335_17445	COG0277	FAD linked oxidase domain protein
J6335_17455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J6335_17480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J6335_17485	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
J6335_17490	COG0438	transferase activity, transferring glycosyl groups
J6335_17510	COG0438	transferase activity, transferring glycosyl groups
J6335_17515	COG0626	cystathionine gamma-synthase activity
J6335_17545	COG0625	glutathione transferase activity
J6335_17555	COG0513	Belongs to the DEAD box helicase family
J6335_17560	COG0720	synthase
J6335_17570	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J6335_17580	COG1956	GAF domain-containing protein
J6335_17595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J6335_17600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J6335_17610	COG4991	sh3 domain protein
J6335_17620	COG0339	signal peptide processing
J6335_17635	COG2132	Multicopper oxidase
J6335_17670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J6335_17675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J6335_17680	COG1136	(ABC) transporter
J6335_17685	COG0577	efflux transmembrane transporter activity
J6335_17685	COG1136	(ABC) transporter
J6335_17705	COG4191	Histidine kinase
J6335_17710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J6335_17735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J6335_17740	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J6335_17745	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J6335_17750	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J6335_17755	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J6335_17770	COG0356	it plays a direct role in the translocation of protons across the membrane
J6335_17790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J6335_17800	COG0508	dehydrogenase complex catalyzes the overall conversion of
J6335_17835	COG2011	ABC-type metal ion transport system permease component
J6335_17840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J6335_17845	COG0697	spore germination
J6335_17850	COG1666	GTP binding
J6335_17860	COG5002	protein histidine kinase activity
J6335_17860	COG2198	Histidine kinase
J6335_17860	COG0784	Response regulator, receiver
J6335_17885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J6335_17890	COG1187	pseudouridine synthase activity
J6335_17895	COG2813	Specifically methylates the guanine in position
J6335_17910	COG3039	Transposase
J6335_17915	COG3328	transposase activity
J6335_17930	COG2205	protein histidine kinase activity
J6335_17930	COG2202	Pas domain
J6335_17950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J6335_17955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J6335_18010	COG0842	Transport permease protein
J6335_18015	COG1131	(ABC) transporter
J6335_18020	COG0025	NhaP-type Na H and K H
J6335_18025	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
J6335_18030	COG1573	uracil-dna glycosylase
J6335_18040	COG3384	dioxygenase
J6335_18050	COG0583	DNA-binding transcription factor activity
J6335_18060	COG0667	Aldo Keto reductase
J6335_18070	COG3590	peptidase
J6335_18085	COG0531	amino acid
J6335_18100	COG2972	Histidine kinase
J6335_18115	COG3685	Protein conserved in bacteria
J6335_18120	COG3546	catalase activity
J6335_18170	COG1271	oxidase subunit
J6335_18175	COG1294	oxidase, subunit
J6335_18190	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_18210	COG1063	alcohol dehydrogenase
J6335_18220	COG3328	transposase activity
J6335_18290	COG0251	oxidation-reduction process
J6335_18320	COG0659	secondary active sulfate transmembrane transporter activity
J6335_18325	COG0038	chloride channel
J6335_18335	COG0024	Methionine aminopeptidase
J6335_18370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J6335_18375	COG1490	D-aminoacyl-tRNA deacylase activity
J6335_18380	COG1560	Kdo2-lipid A biosynthetic process
J6335_18425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J6335_18425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J6335_18430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J6335_18435	COG0242	peptide deformylase activity
J6335_18440	COG1652	LysM domain
J6335_18445	COG0758	DNA mediated transformation
J6335_18465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J6335_18465	COG1754	DNA topoisomerase type I activity
J6335_18470	COG0009	L-threonylcarbamoyladenylate synthase
J6335_18485	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_18495	COG0616	signal peptide processing
J6335_18500	COG0534	Mate efflux family protein
J6335_18520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J6335_18525	COG0625	glutathione transferase activity
J6335_18545	COG2860	membrane
J6335_18550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J6335_18555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J6335_18560	COG2201	protein-glutamate methylesterase activity
J6335_18565	COG2177	Part of the ABC transporter FtsEX involved in
J6335_18570	COG2884	Cell division ATP-binding protein ftsE
J6335_18575	COG0513	Belongs to the DEAD box helicase family
J6335_18580	COG3118	belongs to the thioredoxin family
J6335_18585	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J6335_18595	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
J6335_18620	COG1652	LysM domain
J6335_18625	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J6335_18625	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J6335_18630	COG1473	amidohydrolase
J6335_18635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J6335_18640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J6335_18660	COG5383	Protein conserved in bacteria
J6335_18700	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
J6335_18705	COG3023	N-Acetylmuramoyl-L-alanine amidase
J6335_18725	COG0531	amino acid
J6335_18745	COG3328	transposase activity
J6335_18755	COG2133	pyrroloquinoline quinone binding
J6335_18765	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J6335_18770	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J6335_18785	COG1610	YqeY-like protein
J6335_18790	COG1295	ribonuclease BN
J6335_18795	COG0358	DNA primase activity
J6335_18810	COG0109	protoheme IX farnesyltransferase activity
J6335_18840	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
J6335_18855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J6335_18895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J6335_18900	COG0739	heme binding
J6335_18905	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
J6335_18915	COG2223	nitrite transmembrane transporter activity
J6335_18920	COG0708	Exodeoxyribonuclease III
J6335_18925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J6335_18935	COG1192	Involved in chromosome partitioning
J6335_18940	COG1475	DNA binding
J6335_18955	COG0463	Glycosyl transferase, family 2
J6335_18975	COG0756	dUTP diphosphatase activity
J6335_18980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J6335_18985	COG2003	Belongs to the UPF0758 family
J6335_18990	COG0018	arginyl-trna synthetase
J6335_19005	COG4221	oxidoreductase activity
J6335_19010	COG2755	lipolytic protein G-D-S-L family
J6335_19010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J6335_19020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J6335_19025	COG1166	arginine decarboxylase activity
J6335_19030	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J6335_19050	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J6335_19050	COG3291	Pkd domain containing protein
J6335_19065	COG0606	chelatase, subunit chli
J6335_19080	COG4943	cyclic-guanylate-specific phosphodiesterase activity
J6335_19105	COG1690	Belongs to the RtcB family
J6335_19145	COG1090	epimerase
J6335_19155	COG0642	Histidine kinase
J6335_19175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J6335_19200	COG1011	Hydrolase
J6335_19205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J6335_19220	COG0753	catalase activity
J6335_19235	COG2197	response regulator
J6335_19240	COG4585	Histidine kinase
J6335_19245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J6335_19250	COG1136	(ABC) transporter
J6335_19275	COG0697	spore germination
J6335_19300	COG3328	transposase activity
J6335_19305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J6335_19310	COG0180	Tryptophanyl-tRNA synthetase
J6335_19315	COG3237	CsbD-like
J6335_19355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J6335_19370	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J6335_19375	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J6335_19375	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J6335_19385	COG3228	Belongs to the MtfA family
J6335_19415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J6335_19455	COG3328	transposase activity
J6335_19470	COG1199	ATP-dependent helicase activity
J6335_19485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J6335_19575	COG4555	ABC transporter
J6335_19585	COG1476	TRANSCRIPTIONal
J6335_19605	COG1230	cation diffusion facilitator family transporter
J6335_19610	COG0633	Ferredoxin
J6335_19610	COG0543	2 iron, 2 sulfur cluster binding
J6335_19615	COG1131	(ABC) transporter
J6335_19620	COG0842	Transport permease protein
J6335_19625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J6335_19650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J6335_19670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J6335_19675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J6335_19685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J6335_19685	COG1042	CoA-binding domain protein
J6335_19685	COG0045	succinate-CoA ligase (ADP-forming) activity
J6335_19690	COG2239	Acts as a magnesium transporter
J6335_19710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J6335_19715	COG3387	PFAM Glycoside hydrolase 15-related
J6335_19730	COG3100	YcgL domain-containing protein
J6335_19735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J6335_19745	COG0463	Glycosyl transferase, family 2
J6335_19755	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_19795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J6335_19810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J6335_19845	COG0408	coproporphyrinogen oxidase activity
J6335_19880	COG0515	serine threonine protein kinase
J6335_19885	COG0631	protein serine/threonine phosphatase activity
J6335_19910	COG0667	Aldo Keto reductase
J6335_19915	COG0583	DNA-binding transcription factor activity
J6335_19985	COG0154	amidase activity
J6335_20010	COG3328	transposase activity
J6335_20090	COG0210	DNA helicase
J6335_20105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J6335_20110	COG0583	DNA-binding transcription factor activity
J6335_20115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J6335_20125	COG2159	amidohydrolase
J6335_20150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J6335_20170	COG0357	Ribosomal RNA small subunit methyltransferase G
J6335_20175	COG3540	Alkaline phosphatase
J6335_20185	COG2091	lysine biosynthetic process via aminoadipic acid
J6335_20200	COG0708	Exodeoxyribonuclease III
J6335_20205	COG1940	carbohydrate kinase activity
J6335_20205	COG1846	Transcriptional regulator
J6335_20230	COG3162	membrane
J6335_20240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J6335_20275	COG3507	Belongs to the glycosyl hydrolase 43 family
J6335_20295	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_20300	COG0179	Fumarylacetoacetate (FAA) hydrolase
J6335_20305	COG4948	Mandelate Racemase Muconate Lactonizing
J6335_20310	COG3254	rhamnose metabolic process
J6335_20315	COG0738	Major facilitator superfamily
J6335_20320	COG1414	Transcriptional regulator
J6335_20325	COG2207	Transcriptional regulator
J6335_20325	COG1917	Cupin 2, conserved barrel domain protein
J6335_20335	COG1971	Probably functions as a manganese efflux pump
J6335_20340	COG2205	protein histidine kinase activity
J6335_20350	COG3459	Glycosyltransferase 36 associated
J6335_20355	COG2211	Major facilitator Superfamily
J6335_20360	COG3265	gluconokinase activity
J6335_20365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J6335_20385	COG3328	transposase activity
J6335_20390	COG2911	Protein conserved in bacteria
J6335_20395	COG0729	surface antigen
J6335_20400	COG4771	TonB-dependent receptor
J6335_20405	COG0457	Tetratricopeptide repeat
J6335_20415	COG0752	glycyl-tRNA synthetase alpha subunit
J6335_20420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J6335_20430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J6335_20430	COG0519	Catalyzes the synthesis of GMP from XMP
J6335_20445	COG0805	protein transport
J6335_20450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J6335_20455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J6335_20465	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J6335_20485	COG2974	May be involved in recombination
J6335_20490	COG0037	tRNA processing
J6335_20495	COG2115	Belongs to the xylose isomerase family
J6335_20505	COG3661	Belongs to the glycosyl hydrolase 67 family
J6335_20515	COG4948	Mandelate Racemase Muconate Lactonizing
J6335_20525	COG1472	Belongs to the glycosyl hydrolase 3 family
J6335_20530	COG0246	Mannitol dehydrogenase
J6335_20585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J6335_20610	COG3386	PFAM SMP-30 Gluconolaconase
J6335_20620	COG3250	beta-galactosidase activity
J6335_20625	COG1904	glucuronate isomerase
J6335_20630	COG3693	PFAM glycoside hydrolase, family 10
J6335_20635	COG3693	PFAM glycoside hydrolase, family 10
J6335_20650	COG2211	Major facilitator Superfamily
J6335_20690	COG3039	Transposase
J6335_20715	COG3328	transposase activity
J6335_20760	COG2937	Belongs to the GPAT DAPAT family
J6335_20790	COG0284	orotidine-5'-phosphate decarboxylase activity
J6335_20795	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
J6335_20810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J6335_20860	COG0210	DNA helicase
J6335_20865	COG1435	thymidine kinase activity
J6335_20875	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
J6335_20885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J6335_20915	COG3135	benzoate transporter
J6335_20945	COG0676	glucose-6-phosphate 1-epimerase activity
J6335_20955	COG3012	SEC-C Motif Domain Protein
J6335_20995	COG3328	transposase activity
J6335_21010	COG0730	response to heat
J6335_21020	COG3328	transposase activity
J6335_21040	COG0302	gtp cyclohydrolase
J6335_21055	COG1566	PFAM secretion protein HlyD family protein
J6335_21065	COG1289	transmembrane transporter activity
J6335_21070	COG0477	Major facilitator Superfamily
J6335_21080	COG0583	DNA-binding transcription factor activity
J6335_21085	COG4221	oxidoreductase activity
J6335_21095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J6335_21120	COG3328	transposase activity
J6335_21145	COG0564	pseudouridine synthase activity
J6335_21175	COG3012	SEC-C Motif Domain Protein
J6335_21245	COG4790	Type iii secretion
J6335_21410	COG3039	Transposase
J6335_21505	COG0439	Biotin carboxylase
J6335_21530	COG1028	Short-chain dehydrogenase reductase Sdr
J6335_21585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J6335_21590	COG1074	ATP-dependent DNA helicase activity
J6335_21595	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J6335_21630	COG1127	ABC transporter
J6335_21635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J6335_21640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J6335_21655	COG2853	Lipoprotein
J6335_21670	COG0386	Belongs to the glutathione peroxidase family
J6335_21680	COG1322	Protein conserved in bacteria
J6335_21690	COG0583	DNA-binding transcription factor activity
J6335_21710	COG0531	amino acid
J6335_21715	COG3537	Alpha-1,2-mannosidase
J6335_21730	COG2199	diguanylate cyclase activity
J6335_21730	COG2203	Gaf domain
J6335_21735	COG3835	regulator
J6335_21740	COG1929	Belongs to the glycerate kinase type-1 family
J6335_21745	COG2271	Major facilitator Superfamily
J6335_21760	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J6335_21765	COG0861	Integral membrane protein TerC family
J6335_21775	COG0584	glycerophosphoryl diester phosphodiesterase
J6335_21790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J6335_21795	COG0726	polysaccharide deacetylase
J6335_21805	COG0706	membrane insertase activity
J6335_21810	COG0594	ribonuclease P activity
J6335_21840	COG3328	transposase activity
J6335_21915	COG3328	transposase activity
J6335_21955	COG1487	ribonuclease activity
J6335_21960	COG4691	Plasmid stability protein
J6335_21965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J6335_22065	COG3039	Transposase
J6335_22100	COG3328	transposase activity
J6335_22125	COG4962	Type ii secretion system protein e
J6335_22140	COG3451	type IV secretory pathway VirB4
J6335_22155	COG3846	protein secretion by the type IV secretion system
J6335_22220	COG1487	ribonuclease activity
J6335_22225	COG4691	Plasmid stability protein
J6335_22230	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J6335_22270	COG3328	transposase activity