locus-tag	class	description
OM949_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OM949_00020	COG0187	DNA topoisomerase II activity
OM949_00030	COG0501	Belongs to the peptidase M48B family
OM949_00075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OM949_00085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OM949_00130	COG0793	Belongs to the peptidase S41A family
OM949_00135	COG4942	peptidase
OM949_00145	COG2234	aminopeptidase activity
OM949_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OM949_00160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OM949_00170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OM949_00175	COG1064	alcohol dehydrogenase
OM949_00190	COG0493	'glutamate synthase
OM949_00195	COG0069	glutamate synthase activity
OM949_00195	COG0070	glutamate synthase
OM949_00195	COG0067	glutamate synthase
OM949_00285	COG1111	helicase
OM949_00285	COG1205	dead DEAH box helicase
OM949_00290	COG1272	protein, Hemolysin III
OM949_00310	COG0300	oxidoreductase activity
OM949_00315	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_00340	COG2249	NAD(P)H dehydrogenase (quinone) activity
OM949_00350	COG3039	Transposase
OM949_00365	COG3039	Transposase
OM949_00375	COG3237	CsbD-like
OM949_00425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OM949_00475	COG0714	Associated with various cellular activities
OM949_00515	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
OM949_00525	COG4772	TonB-dependent receptor
OM949_00550	COG1304	FMN binding
OM949_00555	COG1755	Isoprenylcysteine carboxyl methyltransferase
OM949_00560	COG4585	Histidine kinase
OM949_00565	COG2197	response regulator
OM949_00590	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OM949_00655	COG3328	transposase activity
OM949_00660	COG3039	Transposase
OM949_00675	COG0366	Alpha amylase catalytic
OM949_00680	COG0366	Alpha amylase catalytic
OM949_00685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OM949_00705	COG2755	lipolytic protein G-D-S-L family
OM949_00705	COG0657	acetylesterase activity
OM949_00715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OM949_00730	COG3507	Belongs to the glycosyl hydrolase 43 family
OM949_00735	COG1609	Transcriptional regulator
OM949_00740	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
OM949_00745	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_00755	COG2755	lipolytic protein G-D-S-L family
OM949_00765	COG3186	Phenylalanine-4-hydroxylase
OM949_00770	COG1522	sequence-specific DNA binding
OM949_00780	COG1752	Esterase of the alpha-beta hydrolase superfamily
OM949_00790	COG1119	ATPase activity
OM949_00805	COG0517	IMP dehydrogenase activity
OM949_00805	COG1125	glycine betaine transport
OM949_00820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OM949_00850	COG0489	protein tyrosine kinase activity
OM949_00855	COG2062	phosphohistidine phosphatase, SixA
OM949_00865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OM949_00905	COG1968	undecaprenyl-diphosphatase activity
OM949_00910	COG0174	glutamine synthetase
OM949_00915	COG0347	Belongs to the P(II) protein family
OM949_00920	COG0004	ammonium transporteR
OM949_00925	COG3852	Histidine kinase
OM949_00930	COG2204	response regulator
OM949_00935	COG2032	superoxide dismutase activity
OM949_00940	COG2032	superoxide dismutase activity
OM949_00960	COG0183	Belongs to the thiolase family
OM949_00995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OM949_01000	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
OM949_01005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OM949_01030	COG2205	protein histidine kinase activity
OM949_01055	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OM949_01070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OM949_01075	COG3177	Filamentation induced by cAMP protein fic
OM949_01080	COG0596	Alpha beta hydrolase
OM949_01085	COG0727	PFAM Uncharacterised protein family (UPF0153)
OM949_01090	COG0318	PFAM AMP-dependent synthetase and ligase
OM949_01095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OM949_01110	COG1181	Belongs to the D-alanine--D-alanine ligase family
OM949_01120	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OM949_01130	COG0564	pseudouridine synthase activity
OM949_01150	COG1446	asparaginase
OM949_01155	COG0339	signal peptide processing
OM949_01190	COG0475	glutathione-regulated potassium exporter activity
OM949_01195	COG0583	DNA-binding transcription factor activity
OM949_01200	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OM949_01205	COG2224	Isocitrate lyase
OM949_01225	COG3039	Transposase
OM949_01245	COG4770	biotin carboxylase activity
OM949_01250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OM949_01255	COG1960	acyl-CoA dehydrogenase activity
OM949_01320	COG0697	spore germination
OM949_01330	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OM949_01335	COG1846	Transcriptional regulator
OM949_01340	COG1764	response to oxidative stress
OM949_01360	COG2130	NADP-dependent
OM949_01375	COG1187	pseudouridine synthase activity
OM949_01385	COG1643	Atp-dependent helicase
OM949_01390	COG4807	Protein conserved in bacteria
OM949_01400	COG2072	flavoprotein involved in K transport
OM949_01420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OM949_01430	COG0583	DNA-binding transcription factor activity
OM949_01465	COG2252	PERMEase
OM949_01485	COG0084	hydrolase, TatD family'
OM949_01500	COG0583	DNA-binding transcription factor activity
OM949_01505	COG2814	Major facilitator Superfamily
OM949_01520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OM949_01525	COG1902	pentaerythritol trinitrate reductase activity
OM949_01545	COG0745	RESPONSE REGULATOR receiver
OM949_01550	COG2205	protein histidine kinase activity
OM949_01555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OM949_01580	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OM949_01585	COG0583	DNA-binding transcription factor activity
OM949_01620	COG0702	epimerase
OM949_01625	COG1733	regulation of RNA biosynthetic process
OM949_01670	COG0129	dihydroxy-acid dehydratase activity
OM949_01685	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OM949_01740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OM949_01745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OM949_01770	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OM949_01785	COG3485	protocatechuate 3,4-dioxygenase
OM949_01790	COG3485	protocatechuate 3,4-dioxygenase
OM949_01800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OM949_01805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OM949_01815	COG1414	Transcriptional regulator
OM949_01825	COG0657	acetylesterase activity
OM949_01835	COG0445	tRNA wobble uridine modification
OM949_01845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OM949_01875	COG2267	carboxylic ester hydrolase activity
OM949_01885	COG0156	8-amino-7-oxononanoate synthase activity
OM949_01890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OM949_01895	COG1040	competence protein
OM949_01900	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OM949_01920	COG3039	Transposase
OM949_01985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OM949_02055	COG1511	domain protein
OM949_02055	COG3264	Mechanosensitive ion channel
OM949_02060	COG1368	sulfuric ester hydrolase activity
OM949_02065	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OM949_02070	COG2354	Protein conserved in bacteria
OM949_02080	COG0297	glycogen (starch) synthase activity
OM949_02085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OM949_02090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OM949_02115	COG0702	epimerase
OM949_02125	COG1858	cytochrome C peroxidase
OM949_02150	COG3328	transposase activity
OM949_02160	COG3039	Transposase
OM949_02170	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_02205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OM949_02210	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_02220	COG0513	Belongs to the DEAD box helicase family
OM949_02225	COG0508	dehydrogenase complex catalyzes the overall conversion of
OM949_02240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OM949_02250	COG3483	tryptophan 2,3-dioxygenase activity
OM949_02255	COG3104	oligopeptide transport
OM949_02275	COG2852	Protein conserved in bacteria
OM949_02280	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
OM949_02300	COG1320	monovalent cation:proton antiporter activity
OM949_02305	COG2212	antiporter activity
OM949_02315	COG0651	ATP synthesis coupled electron transport
OM949_02320	COG1006	Multisubunit Na H antiporter MnhC subunit
OM949_02325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OM949_02325	COG2111	Na H antiporter
OM949_02345	COG3179	chitinase
OM949_02365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OM949_02370	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
OM949_02390	COG1597	lipid kinase activity
OM949_02420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OM949_02425	COG0134	indole-3-glycerol-phosphate synthase activity
OM949_02435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OM949_02440	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
OM949_02450	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
OM949_02460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OM949_02475	COG1051	belongs to the nudix hydrolase family
OM949_02515	COG0316	Belongs to the HesB IscA family
OM949_02530	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
OM949_02545	COG2814	Major facilitator Superfamily
OM949_02555	COG2814	Major facilitator Superfamily
OM949_02560	COG1289	transmembrane transporter activity
OM949_02570	COG0151	Belongs to the GarS family
OM949_02580	COG0138	bifunctional purine biosynthesis protein purh
OM949_02585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OM949_02590	COG2267	carboxylic ester hydrolase activity
OM949_02595	COG0671	phosphoesterase, PA-phosphatase related
OM949_02595	COG2453	phosphatase
OM949_02620	COG4589	Belongs to the CDS family
OM949_02625	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OM949_02645	COG2264	protein methyltransferase activity
OM949_02660	COG0439	Biotin carboxylase
OM949_02670	COG0511	ligase activity, forming carbon-carbon bonds
OM949_02675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
OM949_02685	COG1324	tolerance protein
OM949_02705	COG0459	protein refolding
OM949_02720	COG3550	peptidyl-serine autophosphorylation
OM949_02725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OM949_02740	COG3386	PFAM SMP-30 Gluconolaconase
OM949_02750	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OM949_02755	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
OM949_02775	COG3039	Transposase
OM949_02795	COG0778	Nitroreductase
OM949_02800	COG2353	YceI-like domain
OM949_02835	COG3052	prosthetic group binding
OM949_02860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OM949_02870	COG1802	Transcriptional regulator
OM949_02925	COG3328	transposase activity
OM949_02935	COG4221	oxidoreductase activity
OM949_02965	COG4221	oxidoreductase activity
OM949_02975	COG0435	Glutathione S-transferase
OM949_03040	COG1959	2 iron, 2 sulfur cluster binding
OM949_03065	COG0697	spore germination
OM949_03070	COG4305	rare lipoprotein A
OM949_03075	COG5297	Belongs to the glycosyl hydrolase family 6
OM949_03085	COG1113	amino acid transport
OM949_03095	COG0598	Magnesium transport protein CorA
OM949_03140	COG5001	Diguanylate cyclase
OM949_03140	COG3447	MASE1 domain protein
OM949_03140	COG5002	protein histidine kinase activity
OM949_03150	COG2205	protein histidine kinase activity
OM949_03150	COG0784	Response regulator, receiver
OM949_03180	COG2943	transferase activity, transferring hexosyl groups
OM949_03190	COG3275	phosphorelay sensor kinase activity
OM949_03200	COG0181	hydroxymethylbilane synthase activity
OM949_03235	COG1505	serine-type exopeptidase activity
OM949_03245	COG0436	Aminotransferase
OM949_03255	COG2832	Protein of unknown function (DUF454)
OM949_03265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OM949_03275	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OM949_03280	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
OM949_03285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
OM949_03310	COG2226	methyltransferase
OM949_03315	COG3300	MHYT domain
OM949_03315	COG5001	Diguanylate cyclase
OM949_03320	COG0308	aminopeptidase N
OM949_03365	COG3284	Transcriptional regulator
OM949_03380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OM949_03385	COG1077	Cell shape determining protein MreB Mrl
OM949_03390	COG1792	Involved in formation and maintenance of cell shape
OM949_03405	COG0772	Belongs to the SEDS family
OM949_03420	COG3039	Transposase
OM949_03455	COG2951	lytic endotransglycosylase activity
OM949_03460	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OM949_03465	COG1686	Belongs to the peptidase S11 family
OM949_03475	COG2921	Belongs to the UPF0250 family
OM949_03480	COG0321	lipoyl(octanoyl) transferase activity
OM949_03485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OM949_03510	COG1051	belongs to the nudix hydrolase family
OM949_03510	COG1056	cytidyltransferase-related domain
OM949_03545	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
OM949_03550	COG0673	inositol 2-dehydrogenase activity
OM949_03555	COG2823	Periplasmic or secreted lipoprotein
OM949_03560	COG4251	negative regulation of phosphorylation
OM949_03565	COG0784	Response regulator, receiver
OM949_03570	COG4191	Histidine kinase
OM949_03575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OM949_03630	COG1459	type II secretion system
OM949_03675	COG2188	Transcriptional regulator
OM949_03685	COG1609	Transcriptional regulator
OM949_03690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OM949_03695	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OM949_03705	COG0617	tRNA 3'-terminal CCA addition
OM949_03720	COG0525	valine-tRNA ligase activity
OM949_03735	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OM949_03745	COG0795	lipopolysaccharide-transporting ATPase activity
OM949_03760	COG4974	Belongs to the 'phage' integrase family
OM949_03770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OM949_03775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OM949_03775	COG0047	phosphoribosylformylglycinamidine synthase activity
OM949_03780	COG5295	Hep Hag repeat protein
OM949_03785	COG1404	Belongs to the peptidase S8 family
OM949_03790	COG5295	Hep Hag repeat protein
OM949_03795	COG1404	Belongs to the peptidase S8 family
OM949_03800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OM949_03805	COG1459	type II secretion system
OM949_03810	COG2165	general secretion pathway protein
OM949_03815	COG4970	Tfp pilus assembly protein FimT
OM949_03820	COG2165	general secretion pathway protein
OM949_03825	COG4795	General secretion pathway protein
OM949_03830	COG3156	type II secretion system protein K
OM949_03835	COG3166	PFAM Fimbrial assembly family protein
OM949_03850	COG1450	Type ii and iii secretion system protein
OM949_03860	COG2188	Transcriptional regulator
OM949_03930	COG1215	transferase activity, transferring glycosyl groups
OM949_03935	COG1215	transferase activity, transferring glycosyl groups
OM949_03940	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
OM949_03965	COG0242	peptide deformylase activity
OM949_03970	COG0488	(ABC) transporter
OM949_03980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OM949_03985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OM949_03995	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OM949_03995	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OM949_04015	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OM949_04020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OM949_04025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OM949_04040	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
OM949_04045	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OM949_04055	COG2205	protein histidine kinase activity
OM949_04060	COG0745	RESPONSE REGULATOR receiver
OM949_04070	COG0277	FAD linked oxidase domain protein
OM949_04075	COG1988	membrane-bound metal-dependent
OM949_04080	COG0792	nuclease activity
OM949_04120	COG3116	cell division
OM949_04130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OM949_04135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OM949_04140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OM949_04150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OM949_04155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OM949_04160	COG1181	Belongs to the D-alanine--D-alanine ligase family
OM949_04165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OM949_04180	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
OM949_04190	COG0739	heme binding
OM949_04195	COG0653	protein targeting
OM949_04200	COG0494	nUDIX hydrolase
OM949_04210	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OM949_04235	COG0366	Alpha amylase catalytic
OM949_04270	COG2226	methyltransferase
OM949_04275	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
OM949_04285	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OM949_04325	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OM949_04335	COG4106	trans-aconitate 2-methyltransferase activity
OM949_04340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OM949_04355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OM949_04360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OM949_04365	COG0667	Aldo Keto reductase
OM949_04375	COG4771	TonB-dependent receptor
OM949_04395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OM949_04400	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
OM949_04410	COG2175	clavaminate synthase activity
OM949_04420	COG4181	ATPase activity
OM949_04435	COG0642	Histidine kinase
OM949_04445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OM949_04455	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
OM949_04465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OM949_04470	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
OM949_04485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OM949_04490	COG2967	ApaG domain
OM949_04495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OM949_04500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
OM949_04505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OM949_04510	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OM949_04520	COG0123	including yeast histone deacetylase and acetoin utilization protein
OM949_04525	COG2096	Adenosyltransferase
OM949_04535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OM949_04540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OM949_04570	COG3384	dioxygenase
OM949_04575	COG0583	DNA-binding transcription factor activity
OM949_04580	COG0318	PFAM AMP-dependent synthetase and ligase
OM949_04590	COG1024	Enoyl-CoA hydratase
OM949_04610	COG3386	PFAM SMP-30 Gluconolaconase
OM949_04620	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
OM949_04640	COG0697	spore germination
OM949_04650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OM949_04675	COG2197	response regulator
OM949_04685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OM949_04700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OM949_04705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OM949_04710	COG0583	DNA-binding transcription factor activity
OM949_04715	COG3634	alkyl hydroperoxide reductase activity
OM949_04725	COG2890	protein-(glutamine-N5) methyltransferase activity
OM949_04745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OM949_04745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OM949_04800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OM949_04805	COG1404	Belongs to the peptidase S8 family
OM949_04810	COG1404	Belongs to the peptidase S8 family
OM949_04815	COG1404	Belongs to the peptidase S8 family
OM949_04820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OM949_04845	COG1295	ribonuclease BN
OM949_04850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OM949_04855	COG1254	Belongs to the acylphosphatase family
OM949_04870	COG0521	Mo-molybdopterin cofactor biosynthetic process
OM949_04880	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OM949_04885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
OM949_04895	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OM949_04900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OM949_04910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OM949_04915	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
OM949_04920	COG0193	aminoacyl-tRNA hydrolase activity
OM949_04925	COG0012	GTP binding
OM949_04945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OM949_04960	COG0250	Participates in transcription elongation, termination and antitermination
OM949_04965	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OM949_04970	COG0081	regulation of translation
OM949_04975	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OM949_04985	COG0085	RNA polymerase activity
OM949_04990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OM949_04995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OM949_05000	COG0049	tRNA binding
OM949_05005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OM949_05010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OM949_05030	COG3328	transposase activity
OM949_05035	COG0051	transcription antitermination factor activity, RNA binding
OM949_05040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OM949_05045	COG0088	Forms part of the polypeptide exit tunnel
OM949_05050	COG0089	rRNA binding
OM949_05055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OM949_05060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OM949_05070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OM949_05075	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OM949_05080	COG0255	Belongs to the universal ribosomal protein uL29 family
OM949_05085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OM949_05095	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OM949_05100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OM949_05110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OM949_05115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OM949_05120	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
OM949_05130	COG1841	ribosomal large subunit assembly
OM949_05135	COG0200	Binds to the 23S rRNA
OM949_05140	COG0201	protein transport
OM949_05165	COG0203	ribosomal protein L17
OM949_05170	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
OM949_05190	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
OM949_05200	COG0154	amidase activity
OM949_05210	COG1217	gtp-binding protein TYPA
OM949_05215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OM949_05220	COG0039	L-malate dehydrogenase activity
OM949_05225	COG0625	glutathione transferase activity
OM949_05240	COG0446	pyridine nucleotide-disulphide oxidoreductase
OM949_05240	COG1902	pentaerythritol trinitrate reductase activity
OM949_05245	COG0604	alcohol dehydrogenase
OM949_05250	COG3039	Transposase
OM949_05255	COG2885	chlorophyll binding
OM949_05275	COG0156	8-amino-7-oxononanoate synthase activity
OM949_05280	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
OM949_05285	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
OM949_05290	COG4208	sulfate ABC transporter
OM949_05295	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
OM949_05330	COG0406	alpha-ribazole phosphatase activity
OM949_05340	COG0285	dihydrofolate synthase activity
OM949_05360	COG2833	Protein of unknown function (DUF455)
OM949_05375	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OM949_05380	COG0671	phosphoesterase, PA-phosphatase related
OM949_05385	COG0438	transferase activity, transferring glycosyl groups
OM949_05395	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
OM949_05410	COG4783	chaperone-mediated protein folding
OM949_05425	COG0473	3-isopropylmalate dehydrogenase activity
OM949_05465	COG3328	transposase activity
OM949_05480	COG0544	peptidyl-prolyl cis-trans isomerase activity
OM949_05490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OM949_05520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OM949_05530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OM949_05540	COG0328	RNA-DNA hybrid ribonuclease activity
OM949_05545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OM949_05550	COG0631	protein serine/threonine phosphatase activity
OM949_05575	COG0859	PFAM glycosyl transferase family 9
OM949_05580	COG3642	lipopolysaccharide core region biosynthetic process
OM949_05585	COG1234	tRNA 3'-trailer cleavage
OM949_05590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OM949_05600	COG0315	cyclic pyranopterin monophosphate synthase activity
OM949_05605	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
OM949_05610	COG0314	molybdopterin synthase activity
OM949_05630	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
OM949_05635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OM949_05640	COG0537	adenosine 5'-monophosphoramidase activity
OM949_05660	COG0714	Associated with various cellular activities
OM949_05670	COG0424	maF-like protein
OM949_05675	COG1399	metal-binding, possibly nucleic acid-binding protein
OM949_05680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OM949_05685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OM949_05700	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_05715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OM949_05720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OM949_05750	COG3829	transcription factor binding
OM949_05795	COG2373	Large extracellular alpha-helical protein
OM949_05815	COG3852	Histidine kinase
OM949_05820	COG4953	penicillin-binding protein 1C
OM949_05830	COG0678	peroxiredoxin activity
OM949_05850	COG0330	HflC and HflK could
OM949_05855	COG0330	HflC and HflK could
OM949_05865	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OM949_05870	COG0308	aminopeptidase N
OM949_05880	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_05885	COG1309	transcriptional regulator
OM949_05930	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OM949_05940	COG3387	PFAM Glycoside hydrolase 15-related
OM949_05945	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_05950	COG3537	Alpha-1,2-mannosidase
OM949_05970	COG0492	ferredoxin-NADP+ reductase activity
OM949_06000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OM949_06005	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
OM949_06010	COG2080	2 iron, 2 sulfur cluster binding
OM949_06045	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OM949_06060	COG0587	DNA-directed DNA polymerase activity
OM949_06080	COG1297	OPT oligopeptide transporter protein
OM949_06105	COG0823	Involved in the tonB-independent uptake of proteins
OM949_06105	COG1506	peptidase
OM949_06135	COG1917	Cupin 2, conserved barrel domain protein
OM949_06135	COG2207	Transcriptional regulator
OM949_06140	COG3328	transposase activity
OM949_06145	COG0753	catalase activity
OM949_06150	COG0656	L-ascorbic acid biosynthetic process
OM949_06160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OM949_06160	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OM949_06185	COG2814	Major facilitator Superfamily
OM949_06215	COG2194	sulfuric ester hydrolase activity
OM949_06230	COG0745	RESPONSE REGULATOR receiver
OM949_06235	COG0642	Histidine kinase
OM949_06245	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
OM949_06250	COG2894	cell division
OM949_06255	COG0850	regulation of cytokinetic process
OM949_06265	COG4585	Histidine kinase
OM949_06270	COG2197	response regulator
OM949_06285	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
OM949_06310	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
OM949_06320	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
OM949_06335	COG1595	DNA-templated transcription, initiation
OM949_06345	COG1946	Acyl-CoA thioesterase
OM949_06360	COG0824	Thioesterase
OM949_06365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OM949_06370	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OM949_06375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OM949_06380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OM949_06385	COG0268	Binds directly to 16S ribosomal RNA
OM949_06395	COG0196	riboflavin kinase activity
OM949_06400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OM949_06405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OM949_06410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OM949_06425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OM949_06430	COG1845	cytochrome c oxidase, subunit III
OM949_06435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OM949_06450	COG3152	Membrane
OM949_06460	COG2207	Transcriptional regulator
OM949_06465	COG0326	Molecular chaperone. Has ATPase activity
OM949_06475	COG1366	Belongs to the anti-sigma-factor antagonist family
OM949_06480	COG1366	Belongs to the anti-sigma-factor antagonist family
OM949_06510	COG4771	TonB-dependent receptor
OM949_06520	COG5507	3-demethylubiquinone-9 3-methyltransferase
OM949_06525	COG2205	protein histidine kinase activity
OM949_06535	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OM949_06540	COG2205	protein histidine kinase activity
OM949_06540	COG3437	response regulator, receiver
OM949_06540	COG3850	Histidine kinase
OM949_06540	COG4999	Histidine kinase
OM949_06545	COG0784	Response regulator, receiver
OM949_06545	COG4191	Histidine kinase
OM949_06570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OM949_06580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OM949_06585	COG0228	four-way junction DNA binding
OM949_06590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OM949_06595	COG0336	Belongs to the RNA methyltransferase TrmD family
OM949_06600	COG0335	large ribosomal subunit rRNA binding
OM949_06605	COG0534	Mate efflux family protein
OM949_06630	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
OM949_06640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OM949_06645	COG2801	Transposase and inactivated derivatives
OM949_06695	COG3250	beta-galactosidase activity
OM949_06700	COG3867	Arabinogalactan endo-beta-1,4-galactanase
OM949_06720	COG1960	acyl-CoA dehydrogenase activity
OM949_06750	COG0457	Tetratricopeptide repeat
OM949_06760	COG0457	Tetratricopeptide repeat
OM949_06770	COG1024	Enoyl-CoA hydratase
OM949_06770	COG1250	3-hydroxyacyl-CoA dehydrogenase
OM949_06785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OM949_06790	COG0481	GTPase activity
OM949_06805	COG0571	ribonuclease III activity
OM949_06810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OM949_06815	COG1381	Involved in DNA repair and RecF pathway recombination
OM949_06825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OM949_06830	COG2954	triphosphatase activity
OM949_06835	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OM949_06840	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
OM949_06845	COG3046	protein related to deoxyribodipyrimidine photolyase
OM949_06850	COG1472	Belongs to the glycosyl hydrolase 3 family
OM949_06855	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
OM949_06860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
OM949_06865	COG1278	Cold shock
OM949_06870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OM949_06880	COG1201	RNA secondary structure unwinding
OM949_06885	COG1793	dna ligase
OM949_06895	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
OM949_06895	COG1793	dna ligase
OM949_06930	COG0183	Belongs to the thiolase family
OM949_06950	COG1451	nucleotide metabolic process
OM949_06955	COG5487	UPF0391 membrane protein
OM949_06965	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OM949_06980	COG1077	Cell shape determining protein MreB Mrl
OM949_06985	COG1047	Peptidyl-prolyl cis-trans
OM949_06995	COG2824	Alkylphosphonate utilization operon protein PhnA
OM949_07005	COG1902	pentaerythritol trinitrate reductase activity
OM949_07010	COG2814	Major facilitator Superfamily
OM949_07045	COG0392	lysyltransferase activity
OM949_07045	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
OM949_07055	COG0251	oxidation-reduction process
OM949_07060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OM949_07075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OM949_07100	COG1595	DNA-templated transcription, initiation
OM949_07115	COG2878	Part of a membrane complex involved in electron transport
OM949_07125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OM949_07125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OM949_07145	COG0346	lactoylglutathione lyase activity
OM949_07160	COG0833	amino acid
OM949_07165	COG2040	homocysteine
OM949_07175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
OM949_07195	COG1695	Transcriptional regulator
OM949_07215	COG1981	membrane
OM949_07230	COG0825	malonyl-CoA metabolic process
OM949_07245	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OM949_07250	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OM949_07255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OM949_07260	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OM949_07275	COG0750	zinc metalloprotease
OM949_07280	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
OM949_07285	COG0575	Belongs to the CDS family
OM949_07290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OM949_07295	COG0233	cytoplasmic translational termination
OM949_07300	COG0528	UMP kinase activity
OM949_07310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OM949_07315	COG0052	Belongs to the universal ribosomal protein uS2 family
OM949_07365	COG1393	Belongs to the ArsC family
OM949_07370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OM949_07380	COG0367	asparagine synthase
OM949_07390	COG4774	siderophore transport
OM949_07440	COG2801	Transposase and inactivated derivatives
OM949_07445	COG3328	transposase activity
OM949_07480	COG1566	PFAM secretion protein HlyD family protein
OM949_07485	COG2814	Major facilitator Superfamily
OM949_07515	COG3104	oligopeptide transport
OM949_07545	COG0339	signal peptide processing
OM949_07550	COG0386	Belongs to the glutathione peroxidase family
OM949_07610	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OM949_07615	COG0084	hydrolase, TatD family'
OM949_07630	COG1960	acyl-CoA dehydrogenase activity
OM949_07645	COG0367	asparagine synthase
OM949_07655	COG0305	Participates in initiation and elongation during chromosome replication
OM949_07660	COG0415	Belongs to the DNA photolyase family
OM949_07675	COG0583	DNA-binding transcription factor activity
OM949_07720	COG3706	GGDEF domain
OM949_07745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OM949_07760	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OM949_07770	COG0497	DNA recombination
OM949_07775	COG1420	regulation of RNA biosynthetic process
OM949_07780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OM949_07785	COG0443	Heat shock 70 kDa protein
OM949_07790	COG0484	heat shock protein binding
OM949_07795	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
OM949_07825	COG0583	DNA-binding transcription factor activity
OM949_07830	COG1132	(ABC) transporter
OM949_07865	COG2850	peptidyl-arginine hydroxylation
OM949_07885	COG1253	flavin adenine dinucleotide binding
OM949_07915	COG1131	(ABC) transporter
OM949_07920	COG1725	Transcriptional regulator
OM949_07930	COG0386	Belongs to the glutathione peroxidase family
OM949_07950	COG2900	Belongs to the SlyX family
OM949_07980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OM949_07990	COG1410	methionine synthase
OM949_07990	COG0646	methionine synthase
OM949_07995	COG1410	methionine synthase
OM949_07995	COG0646	methionine synthase
OM949_08000	COG2226	methyltransferase
OM949_08005	COG1960	acyl-CoA dehydrogenase activity
OM949_08025	COG0557	exoribonuclease II activity
OM949_08035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OM949_08045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OM949_08055	COG0704	Plays a role in the regulation of phosphate uptake
OM949_08060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OM949_08065	COG0581	inorganic phosphate transmembrane transporter activity
OM949_08070	COG0573	inorganic phosphate transmembrane transporter activity
OM949_08075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OM949_08100	COG0659	secondary active sulfate transmembrane transporter activity
OM949_08105	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OM949_08115	COG1024	Enoyl-CoA hydratase
OM949_08125	COG0494	nUDIX hydrolase
OM949_08160	COG0488	(ABC) transporter
OM949_08170	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OM949_08170	COG0116	Belongs to the methyltransferase superfamily
OM949_08175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OM949_08195	COG2925	Exonuclease
OM949_08205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OM949_08210	COG3844	kynureninase activity
OM949_08220	COG0662	Cupin 2, conserved barrel domain protein
OM949_08225	COG0288	reversible hydration of carbon dioxide
OM949_08305	COG0017	Asparaginyl-tRNA synthetase
OM949_08310	COG0316	Belongs to the HesB IscA family
OM949_08315	COG0360	Binds together with S18 to 16S ribosomal RNA
OM949_08320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OM949_08325	COG0359	binds to the 23S rRNA
OM949_08335	COG3115	cell septum assembly
OM949_08345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OM949_08350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OM949_08355	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OM949_08365	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
OM949_08375	COG4993	Dehydrogenase
OM949_08385	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
OM949_08395	COG2986	histidine ammonia-lyase
OM949_08400	COG1228	amidohydrolase
OM949_08440	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
OM949_08445	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
OM949_08450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
OM949_08455	COG1605	Chorismate mutase
OM949_08455	COG0077	Prephenate dehydratase
OM949_08460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OM949_08475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OM949_08480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OM949_08485	COG0583	DNA-binding transcription factor activity
OM949_08510	COG0840	transmembrane signaling receptor activity
OM949_08530	COG4191	Histidine kinase
OM949_08530	COG0784	Response regulator, receiver
OM949_08535	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
OM949_08555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OM949_08565	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
OM949_08575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OM949_08590	COG1595	DNA-templated transcription, initiation
OM949_08640	COG2244	polysaccharide biosynthetic process
OM949_08670	COG2264	protein methyltransferase activity
OM949_08680	COG0438	transferase activity, transferring glycosyl groups
OM949_08695	COG1136	(ABC) transporter
OM949_08705	COG0477	Major facilitator Superfamily
OM949_08710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OM949_08725	COG1253	flavin adenine dinucleotide binding
OM949_08735	COG0306	phosphate transporter
OM949_08760	COG0504	CTP synthase activity
OM949_08765	COG2877	3-deoxy-8-phosphooctulonate synthase activity
OM949_08775	COG0148	phosphopyruvate hydratase activity
OM949_08780	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OM949_08790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
OM949_08795	COG0585	pseudouridine synthase activity
OM949_08800	COG2840	Smr protein MutS2
OM949_08805	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OM949_08810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OM949_08815	COG1238	metal cluster binding
OM949_08825	COG3737	Protein of unknown function (DUF498/DUF598)
OM949_08830	COG1534	Rna-binding protein
OM949_08835	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
OM949_08845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OM949_08850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OM949_08860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OM949_08865	COG1546	Belongs to the CinA family
OM949_08875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OM949_08880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
OM949_08885	COG2137	regulation of response to DNA damage stimulus
OM949_08890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OM949_08895	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
OM949_08915	COG0583	DNA-binding transcription factor activity
OM949_08940	COG0351	phosphomethylpyrimidine kinase
OM949_08955	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
OM949_08960	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OM949_08975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OM949_08985	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OM949_08990	COG3734	2-keto-3-deoxy-galactonokinase
OM949_09000	COG4948	Mandelate Racemase Muconate Lactonizing
OM949_09005	COG0800	Aldolase
OM949_09040	COG1501	Belongs to the glycosyl hydrolase 31 family
OM949_09050	COG1070	Carbohydrate kinase
OM949_09055	COG2115	Belongs to the xylose isomerase family
OM949_09060	COG0477	Major facilitator Superfamily
OM949_09080	COG0860	N-Acetylmuramoyl-L-alanine amidase
OM949_09085	COG1469	GTP cyclohydrolase I activity
OM949_09110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
OM949_09115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OM949_09120	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OM949_09125	COG0166	Belongs to the GPI family
OM949_09145	COG1472	Belongs to the glycosyl hydrolase 3 family
OM949_09155	COG3706	GGDEF domain
OM949_09155	COG4251	negative regulation of phosphorylation
OM949_09155	COG2203	Gaf domain
OM949_09155	COG5001	Diguanylate cyclase
OM949_09160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OM949_09165	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
OM949_09175	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
OM949_09180	COG0671	phosphoesterase, PA-phosphatase related
OM949_09190	COG1794	racemase activity, acting on amino acids and derivatives
OM949_09195	COG0697	spore germination
OM949_09200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
OM949_09205	COG0167	dihydroorotate dehydrogenase activity
OM949_09220	COG1012	belongs to the aldehyde dehydrogenase family
OM949_09235	COG3328	transposase activity
OM949_09240	COG0366	Alpha amylase catalytic
OM949_09260	COG1082	Xylose isomerase domain protein TIM barrel
OM949_09270	COG2211	Major facilitator Superfamily
OM949_09290	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OM949_09305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OM949_09310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OM949_09310	COG0072	phenylalanine-tRNA ligase activity
OM949_09360	COG0438	transferase activity, transferring glycosyl groups
OM949_09365	COG0438	transferase activity, transferring glycosyl groups
OM949_09375	COG0438	transferase activity, transferring glycosyl groups
OM949_09400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OM949_09410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OM949_09430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OM949_09440	COG1960	acyl-CoA dehydrogenase activity
OM949_09450	COG3040	lipid binding
OM949_09465	COG0322	excinuclease ABC activity
OM949_09480	COG4191	Histidine kinase
OM949_09480	COG0784	Response regulator, receiver
OM949_09500	COG1194	a g-specific adenine glycosylase
OM949_09505	COG0552	protein localization to endoplasmic reticulum
OM949_09515	COG3938	Belongs to the proline racemase family
OM949_09520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OM949_09535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OM949_09545	COG0006	proline dipeptidase activity
OM949_09560	COG0531	amino acid
OM949_09665	COG3328	transposase activity
OM949_09675	COG0840	transmembrane signaling receptor activity
OM949_09685	COG3328	transposase activity
OM949_09720	COG3210	domain, Protein
OM949_09725	COG3328	transposase activity
OM949_09730	COG0460	homoserine dehydrogenase
OM949_09730	COG0527	aspartate kinase activity
OM949_09765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OM949_09770	COG0124	histidyl-tRNA synthetase
OM949_09780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OM949_09785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OM949_09790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OM949_09795	COG0131	Imidazoleglycerol-phosphate dehydratase
OM949_09795	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OM949_09800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OM949_09805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
OM949_09810	COG0107	imidazoleglycerol-phosphate synthase activity
OM949_09815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OM949_09815	COG0140	phosphoribosyl-ATP diphosphatase activity
OM949_09830	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
OM949_09835	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
OM949_09840	COG0235	Class ii aldolase
OM949_09845	COG0531	amino acid
OM949_09850	COG0531	amino acid
OM949_09860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OM949_09865	COG0277	FAD linked oxidase domain protein
OM949_09885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OM949_09930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OM949_09935	COG2258	MOSC domain
OM949_09940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OM949_09945	COG0505	Belongs to the CarA family
OM949_09955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OM949_09960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OM949_09970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OM949_09990	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
OM949_10000	COG2205	protein histidine kinase activity
OM949_10000	COG2198	Histidine kinase
OM949_10000	COG0784	Response regulator, receiver
OM949_10005	COG0784	Response regulator, receiver
OM949_10005	COG2198	Histidine kinase
OM949_10005	COG2205	protein histidine kinase activity
OM949_10010	COG1024	Enoyl-CoA hydratase
OM949_10015	COG0318	PFAM AMP-dependent synthetase and ligase
OM949_10050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OM949_10060	COG2201	protein-glutamate methylesterase activity
OM949_10065	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
OM949_10075	COG0840	transmembrane signaling receptor activity
OM949_10085	COG0835	chemotaxis
OM949_10095	COG0840	transmembrane signaling receptor activity
OM949_10100	COG0840	transmembrane signaling receptor activity
OM949_10105	COG0840	transmembrane signaling receptor activity
OM949_10110	COG0840	transmembrane signaling receptor activity
OM949_10115	COG0840	transmembrane signaling receptor activity
OM949_10130	COG0840	transmembrane signaling receptor activity
OM949_10135	COG0840	transmembrane signaling receptor activity
OM949_10140	COG0840	transmembrane signaling receptor activity
OM949_10145	COG0840	transmembrane signaling receptor activity
OM949_10155	COG0840	transmembrane signaling receptor activity
OM949_10170	COG0840	transmembrane signaling receptor activity
OM949_10175	COG0840	transmembrane signaling receptor activity
OM949_10185	COG0745	RESPONSE REGULATOR receiver
OM949_10195	COG0835	chemotaxis
OM949_10200	COG1192	Involved in chromosome partitioning
OM949_10205	COG1360	Flagellar Motor Protein
OM949_10210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OM949_10245	COG3328	transposase activity
OM949_10260	COG2198	Histidine kinase
OM949_10260	COG0784	Response regulator, receiver
OM949_10260	COG0643	Histidine kinase
OM949_10290	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OM949_10315	COG3039	Transposase
OM949_10325	COG1684	flagellar biosynthetic protein fliR
OM949_10345	COG3190	flagellar
OM949_10395	COG1677	Flagellar hook-basal body complex protein FliE
OM949_10420	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
OM949_10450	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_10455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OM949_10475	COG2201	protein-glutamate methylesterase activity
OM949_10510	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
OM949_10520	COG3039	Transposase
OM949_10525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OM949_10535	COG1705	Flagellar rod assembly protein muramidase FlgJ
OM949_10535	COG3951	Flagellar rod assembly protein muramidase FlgJ
OM949_10540	COG1706	bacterial-type flagellum-dependent cell motility
OM949_10545	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
OM949_10555	COG4787	bacterial-type flagellum-dependent cell motility
OM949_10565	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
OM949_10570	COG1558	bacterial-type flagellum-dependent cell motility
OM949_10580	COG0784	Response regulator, receiver
OM949_10580	COG0835	chemotaxis
OM949_10600	COG5002	protein histidine kinase activity
OM949_10610	COG4585	Histidine kinase
OM949_10630	COG2915	High frequency lysogenization protein hflD homolog
OM949_10635	COG0482	sulfurtransferase activity
OM949_10655	COG0542	response to heat
OM949_10665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OM949_10675	COG0492	ferredoxin-NADP+ reductase activity
OM949_10680	COG1674	ftsk spoiiie
OM949_10690	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OM949_10700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OM949_10705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OM949_10710	COG0183	Belongs to the thiolase family
OM949_10715	COG1024	Enoyl-CoA hydratase
OM949_10715	COG1250	3-hydroxyacyl-CoA dehydrogenase
OM949_10730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
OM949_10750	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OM949_10755	COG1160	GTP binding
OM949_10760	COG0303	'Molybdopterin
OM949_10765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OM949_10800	COG0708	Exodeoxyribonuclease III
OM949_10810	COG0303	'Molybdopterin
OM949_10815	COG0746	molybdenum cofactor guanylyltransferase activity
OM949_10840	COG1648	precorrin-2 dehydrogenase activity
OM949_10840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OM949_10850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OM949_10855	COG2223	nitrite transmembrane transporter activity
OM949_10860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OM949_10870	COG0243	molybdopterin cofactor binding
OM949_10890	COG3685	Protein conserved in bacteria
OM949_10910	COG5001	Diguanylate cyclase
OM949_10920	COG4566	intracellular signal transduction
OM949_10970	COG3328	transposase activity
OM949_10975	COG3039	Transposase
OM949_10990	COG3328	transposase activity
OM949_11000	COG1073	alpha beta
OM949_11000	COG2226	methyltransferase
OM949_11015	COG0363	glucosamine-6-phosphate deaminase activity
OM949_11055	COG1309	transcriptional regulator
OM949_11070	COG2154	pterin-4-alpha-carbinolamine dehydratase
OM949_11080	COG0428	transporter
OM949_11085	COG3064	Membrane
OM949_11095	COG1530	ribonuclease E activity
OM949_11100	COG3039	Transposase
OM949_11110	COG1054	Belongs to the UPF0176 family
OM949_11130	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OM949_11155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OM949_11160	COG0322	excinuclease ABC activity
OM949_11170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OM949_11175	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
OM949_11180	COG1663	tetraacyldisaccharide 4'-kinase activity
OM949_11185	COG1132	(ABC) transporter
OM949_11195	COG0811	peptide transport
OM949_11210	COG1136	(ABC) transporter
OM949_11215	COG4591	ABC-type transport system involved in lipoprotein release permease component
OM949_11225	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
OM949_11230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OM949_11245	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OM949_11260	COG0354	folic acid binding
OM949_11270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OM949_11275	COG0837	glucose binding
OM949_11280	COG0363	glucosamine-6-phosphate deaminase activity
OM949_11285	COG0129	dihydroxy-acid dehydratase activity
OM949_11290	COG0800	Aldolase
OM949_11355	COG0784	Response regulator, receiver
OM949_11355	COG2205	protein histidine kinase activity
OM949_11360	COG2183	response to ionizing radiation
OM949_11370	COG0723	plastoquinol--plastocyanin reductase activity
OM949_11370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OM949_11385	COG3243	poly(R)-hydroxyalkanoic acid synthase
OM949_11395	COG1183	phosphatidylcholine synthase activity
OM949_11400	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_11415	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OM949_11430	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OM949_11445	COG1914	H( )-stimulated, divalent metal cation uptake system
OM949_11465	COG2814	Major facilitator Superfamily
OM949_11480	COG1335	isochorismatase
OM949_11495	COG2197	response regulator
OM949_11530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OM949_11580	COG0519	Catalyzes the synthesis of GMP from XMP
OM949_11580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OM949_11590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OM949_11600	COG0475	glutathione-regulated potassium exporter activity
OM949_11600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OM949_11605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OM949_11615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OM949_11620	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
OM949_11630	COG0776	regulation of translation
OM949_11635	COG0539	negative regulation of cytoplasmic translation
OM949_11640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OM949_11655	COG2957	Belongs to the agmatine deiminase family
OM949_11660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OM949_11685	COG0395	ABC-type sugar transport system, permease component
OM949_11690	COG1175	transmembrane transport
OM949_11720	COG2350	Protein conserved in bacteria
OM949_11725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OM949_11730	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OM949_11735	COG1187	pseudouridine synthase activity
OM949_11750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OM949_11755	COG0436	Aminotransferase
OM949_11760	COG4133	protoheme IX ABC transporter activity
OM949_11780	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
OM949_11805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OM949_11815	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
OM949_11820	COG4988	ABC transporter
OM949_11830	COG1294	oxidase, subunit
OM949_11860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OM949_11865	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OM949_11875	COG0165	Argininosuccinate lyase
OM949_11880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OM949_11890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OM949_11895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OM949_11905	COG0137	argininosuccinate synthase activity
OM949_11910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OM949_11920	COG0215	cysteine-tRNA ligase activity
OM949_11925	COG2166	iron-sulfur cluster assembly
OM949_11945	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
OM949_11950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OM949_11975	COG4302	ethanolamine ammonia-lyase activity
OM949_12005	COG3039	Transposase
OM949_12030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OM949_12035	COG0402	S-adenosylhomocysteine deaminase activity
OM949_12045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OM949_12050	COG1509	lysine 2,3-aminomutase activity
OM949_12055	COG3300	MHYT domain
OM949_12055	COG5001	Diguanylate cyclase
OM949_12070	COG0483	inositol monophosphate 1-phosphatase activity
OM949_12075	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OM949_12090	COG0488	(ABC) transporter
OM949_12095	COG0513	Belongs to the DEAD box helicase family
OM949_12100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OM949_12105	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
OM949_12120	COG0625	glutathione transferase activity
OM949_12130	COG4681	YaeQ
OM949_12135	COG2081	HI0933 family
OM949_12145	COG0501	Belongs to the peptidase M48B family
OM949_12150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OM949_12155	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_12180	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OM949_12185	COG0860	N-Acetylmuramoyl-L-alanine amidase
OM949_12190	COG0802	atpase or kinase
OM949_12195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OM949_12195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OM949_12200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OM949_12205	COG1570	exodeoxyribonuclease VII activity
OM949_12215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OM949_12260	COG0835	chemotaxis
OM949_12265	COG0840	transmembrane signaling receptor activity
OM949_12270	COG2094	Belongs to the DNA glycosylase MPG family
OM949_12275	COG1201	RNA secondary structure unwinding
OM949_12295	COG2969	positive regulation of protein catabolic process
OM949_12300	COG0625	glutathione transferase activity
OM949_12305	COG2857	Cytochrome c1
OM949_12310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OM949_12315	COG0723	plastoquinol--plastocyanin reductase activity
OM949_12320	COG0741	lytic transglycosylase activity
OM949_12335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OM949_12340	COG1702	phosphate starvation-inducible protein PhoH
OM949_12350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OM949_12360	COG4535	Mg2 and Co2 transporter CorC
OM949_12375	COG1012	belongs to the aldehyde dehydrogenase family
OM949_12380	COG1177	transmembrane transport
OM949_12385	COG1176	ABC-type spermidine putrescine transport system, permease component I
OM949_12390	COG3842	ATPase activity
OM949_12410	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OM949_12430	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
OM949_12435	COG0174	glutamine synthetase
OM949_12440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OM949_12450	COG2703	oxygen carrier activity
OM949_12455	COG0477	Major facilitator Superfamily
OM949_12465	COG0243	molybdopterin cofactor binding
OM949_12470	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OM949_12475	COG2223	nitrite transmembrane transporter activity
OM949_12485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OM949_12495	COG2733	membrane
OM949_12500	COG0784	Response regulator, receiver
OM949_12500	COG2205	protein histidine kinase activity
OM949_12500	COG5002	protein histidine kinase activity
OM949_12510	COG0477	Major facilitator Superfamily
OM949_12515	COG0840	transmembrane signaling receptor activity
OM949_12545	COG2902	Dehydrogenase
OM949_12555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OM949_12560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OM949_12565	COG1609	Transcriptional regulator
OM949_12570	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OM949_12570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OM949_12575	COG1105	Belongs to the carbohydrate kinase PfkB family
OM949_12580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OM949_12580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OM949_12600	COG3328	transposase activity
OM949_12610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OM949_12620	COG1862	Preprotein translocase
OM949_12625	COG0343	queuine tRNA-ribosyltransferase activity
OM949_12630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
OM949_12665	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OM949_12670	COG3291	Pkd domain containing protein
OM949_12675	COG0405	Gamma-glutamyltransferase
OM949_12680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OM949_12690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OM949_12695	COG0742	ribosomal rna small subunit methyltransferase
OM949_12700	COG0326	Molecular chaperone. Has ATPase activity
OM949_12790	COG3702	type iv secretory pathway
OM949_12810	COG2948	multi-organism process
OM949_12830	COG3505	Type IV secretory pathway VirD4
OM949_12845	COG0556	nucleotide-excision repair
OM949_13010	COG3179	chitinase
OM949_13065	COG4695	Portal protein
OM949_13145	COG3275	phosphorelay sensor kinase activity
OM949_13150	COG1611	Belongs to the LOG family
OM949_13160	COG2095	MarC family integral membrane protein
OM949_13170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OM949_13205	COG1185	polyribonucleotide nucleotidyltransferase activity
OM949_13210	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OM949_13215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OM949_13220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OM949_13225	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OM949_13230	COG0195	Participates in both transcription termination and antitermination
OM949_13235	COG0779	Required for maturation of 30S ribosomal subunits
OM949_13245	COG1007	ATP synthesis coupled electron transport
OM949_13270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OM949_13275	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
OM949_13285	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OM949_13290	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
OM949_13295	COG0649	NAD binding
OM949_13300	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OM949_13305	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OM949_13310	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OM949_13325	COG0149	triose-phosphate isomerase activity
OM949_13330	COG4221	oxidoreductase activity
OM949_13360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OM949_13365	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OM949_13370	COG0159	tryptophan synthase activity
OM949_13380	COG0133	tryptophan synthase activity
OM949_13390	COG0135	phosphoribosylanthranilate isomerase activity
OM949_13395	COG0101	tRNA pseudouridine synthase activity
OM949_13410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OM949_13415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OM949_13420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OM949_13425	COG2890	protein-(glutamine-N5) methyltransferase activity
OM949_13435	COG0688	phosphatidylethanolamine metabolic process
OM949_13445	COG0433	COG0433 Predicted ATPase
OM949_13470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OM949_13475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OM949_13500	COG0717	Belongs to the dCTP deaminase family
OM949_13505	COG0489	protein tyrosine kinase activity
OM949_13535	COG3590	peptidase
OM949_13560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OM949_13565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OM949_13570	COG2311	Membrane
OM949_13575	COG1047	Peptidyl-prolyl cis-trans
OM949_13580	COG0791	NLP P60 protein
OM949_13585	COG0791	NLP P60 protein
OM949_13595	COG4106	trans-aconitate 2-methyltransferase activity
OM949_13600	COG1301	dicarboxylic acid transport
OM949_13605	COG1785	Belongs to the alkaline phosphatase family
OM949_13610	COG0037	tRNA processing
OM949_13615	COG1722	exodeoxyribonuclease VII activity
OM949_13620	COG0142	geranyltranstransferase activity
OM949_13625	COG4104	PAAR repeat-containing protein
OM949_13635	COG0312	modulator of DNA gyrase
OM949_13640	COG3028	Belongs to the UPF0307 family
OM949_13645	COG0312	modulator of DNA gyrase
OM949_13655	COG3164	Protein of unknown function
OM949_13665	COG0424	maF-like protein
OM949_13670	COG2968	Membrane
OM949_13685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
OM949_13700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OM949_13715	COG0495	leucyl-tRNA aminoacylation
OM949_13725	COG3118	belongs to the thioredoxin family
OM949_13750	COG2155	Conserved Protein
OM949_13800	COG1132	(ABC) transporter
OM949_13830	COG0745	RESPONSE REGULATOR receiver
OM949_13835	COG5000	phosphorelay sensor kinase activity
OM949_13835	COG5002	protein histidine kinase activity
OM949_13840	COG0475	glutathione-regulated potassium exporter activity
OM949_13850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OM949_13870	COG1187	pseudouridine synthase activity
OM949_13875	COG5001	Diguanylate cyclase
OM949_13875	COG5002	protein histidine kinase activity
OM949_13885	COG1595	DNA-templated transcription, initiation
OM949_14000	COG0667	Aldo Keto reductase
OM949_14005	COG2814	Major facilitator Superfamily
OM949_14010	COG0583	DNA-binding transcription factor activity
OM949_14020	COG2207	Transcriptional regulator
OM949_14030	COG1309	transcriptional regulator
OM949_14040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OM949_14055	COG0735	belongs to the Fur family
OM949_14060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OM949_14085	COG4452	Inner membrane protein CreD
OM949_14105	COG0745	RESPONSE REGULATOR receiver
OM949_14110	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OM949_14125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OM949_14135	COG2198	Histidine kinase
OM949_14135	COG0643	Histidine kinase
OM949_14140	COG0840	transmembrane signaling receptor activity
OM949_14145	COG0835	chemotaxis
OM949_14150	COG2200	EAL domain
OM949_14150	COG2202	Pas domain
OM949_14150	COG2199	diguanylate cyclase activity
OM949_14155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OM949_14160	COG2201	protein-glutamate methylesterase activity
OM949_14170	COG3590	peptidase
OM949_14185	COG1515	deoxyribonuclease V activity
OM949_14195	COG1741	Belongs to the pirin family
OM949_14210	COG1741	Belongs to the pirin family
OM949_14215	COG1966	Carbon starvation protein
OM949_14220	COG2879	small protein
OM949_14255	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
OM949_14260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OM949_14265	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
OM949_14270	COG2080	2 iron, 2 sulfur cluster binding
OM949_14275	COG0604	alcohol dehydrogenase
OM949_14275	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_14275	COG3321	synthase
OM949_14280	COG2203	Gaf domain
OM949_14280	COG5001	Diguanylate cyclase
OM949_14280	COG4251	negative regulation of phosphorylation
OM949_14280	COG3706	GGDEF domain
OM949_14285	COG0629	single-stranded DNA binding
OM949_14290	COG0142	geranyltranstransferase activity
OM949_14300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OM949_14315	COG0527	aspartate kinase activity
OM949_14320	COG0384	phenazine biosynthesis protein PhzF
OM949_14325	COG0384	phenazine biosynthesis protein PhzF
OM949_14335	COG1764	response to oxidative stress
OM949_14340	COG0540	Belongs to the ATCase OTCase family
OM949_14345	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OM949_14350	COG1678	Uncharacterized ACR, COG1678
OM949_14355	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
OM949_14360	COG0519	Catalyzes the synthesis of GMP from XMP
OM949_14385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OM949_14400	COG0739	heme binding
OM949_14420	COG0693	protein deglycase activity
OM949_14430	COG1959	2 iron, 2 sulfur cluster binding
OM949_14435	COG0719	Fe-S assembly protein
OM949_14440	COG0396	ATPase activity
OM949_14445	COG0719	Fe-S assembly protein
OM949_14450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OM949_14455	COG0456	acetyltransferase
OM949_14460	COG2146	nitrite reductase [NAD(P)H] activity
OM949_14465	COG4774	siderophore transport
OM949_14470	COG3128	pkhd-type hydroxylase
OM949_14495	COG3328	transposase activity
OM949_14500	COG1477	protein flavinylation
OM949_14505	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OM949_14515	COG1555	photosystem II stabilization
OM949_14535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OM949_14545	COG0628	permease
OM949_14555	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OM949_14570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OM949_14590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OM949_14595	COG0271	Belongs to the BolA IbaG family
OM949_14605	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
OM949_14615	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
OM949_14620	COG1137	ATPase activity
OM949_14635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OM949_14640	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
OM949_14645	COG1660	Displays ATPase and GTPase activities
OM949_14655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OM949_14660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OM949_14670	COG2239	Acts as a magnesium transporter
OM949_14680	COG1294	oxidase, subunit
OM949_14690	COG1271	oxidase subunit
OM949_14700	COG1113	amino acid transport
OM949_14725	COG2197	response regulator
OM949_14730	COG0531	amino acid
OM949_14795	COG2814	Major facilitator Superfamily
OM949_14800	COG0754	glutathionylspermidine amidase activity
OM949_14825	COG1842	Phage shock protein A
OM949_14835	COG0259	pyridoxamine-phosphate oxidase activity
OM949_14840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OM949_14845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
OM949_14855	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OM949_14860	COG2814	Major facilitator Superfamily
OM949_14885	COG2205	protein histidine kinase activity
OM949_14885	COG2198	Histidine kinase
OM949_14885	COG0784	Response regulator, receiver
OM949_14890	COG2353	YceI-like domain
OM949_14910	COG1760	l-serine dehydratase
OM949_14925	COG0460	homoserine dehydrogenase
OM949_14925	COG0527	aspartate kinase activity
OM949_14930	COG0626	cystathionine gamma-synthase activity
OM949_14935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OM949_14940	COG0739	heme binding
OM949_14945	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OM949_14950	COG1272	protein, Hemolysin III
OM949_14955	COG2982	Protein involved in outer membrane biogenesis
OM949_14960	COG0516	GMP reductase activity
OM949_14960	COG0517	IMP dehydrogenase activity
OM949_14965	COG0463	Glycosyl transferase, family 2
OM949_14970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OM949_14975	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OM949_14985	COG4771	TonB-dependent receptor
OM949_14990	COG1309	transcriptional regulator
OM949_15000	COG1960	acyl-CoA dehydrogenase activity
OM949_15025	COG3328	transposase activity
OM949_15050	COG0509	glycine decarboxylation via glycine cleavage system
OM949_15055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OM949_15065	COG0330	HflC and HflK could
OM949_15070	COG1742	UPF0060 membrane protein
OM949_15075	COG3956	TIGRFAM MazG family protein
OM949_15085	COG0494	nUDIX hydrolase
OM949_15095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OM949_15100	COG0837	glucose binding
OM949_15125	COG1388	LysM domain
OM949_15125	COG3858	chitin binding
OM949_15130	COG3525	Glycosyl hydrolase, family 20, catalytic domain
OM949_15140	COG1472	Belongs to the glycosyl hydrolase 3 family
OM949_15155	COG3537	Alpha-1,2-mannosidase
OM949_15190	COG3142	Participates in the control of copper homeostasis
OM949_15195	COG1446	asparaginase
OM949_15220	COG0643	Histidine kinase
OM949_15220	COG0784	Response regulator, receiver
OM949_15220	COG2198	Histidine kinase
OM949_15225	COG0840	transmembrane signaling receptor activity
OM949_15245	COG0189	ligase activity
OM949_15255	COG1397	ADP-ribosylglycohydrolase
OM949_15265	COG1199	ATP-dependent helicase activity
OM949_15275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OM949_15280	COG1215	transferase activity, transferring glycosyl groups
OM949_15290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OM949_15300	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
OM949_15305	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
OM949_15310	COG0535	radical SAM domain protein
OM949_15315	COG0535	radical SAM domain protein
OM949_15330	COG0837	glucose binding
OM949_15340	COG3328	transposase activity
OM949_15350	COG1643	Atp-dependent helicase
OM949_15355	COG0783	Belongs to the Dps family
OM949_15360	COG0514	ATP-dependent DNA helicase (RecQ)
OM949_15395	COG0840	transmembrane signaling receptor activity
OM949_15415	COG3920	Histidine kinase
OM949_15420	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OM949_15430	COG0602	queuosine metabolic process
OM949_15440	COG2885	chlorophyll binding
OM949_15445	COG0823	Involved in the tonB-independent uptake of proteins
OM949_15455	COG0848	biopolymer transport protein
OM949_15465	COG0824	Thioesterase
OM949_15470	COG2255	four-way junction helicase activity
OM949_15480	COG3158	transport of potassium into the cell
OM949_15485	COG0632	four-way junction helicase activity
OM949_15490	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
OM949_15495	COG0217	transcriptional regulatory protein
OM949_15510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OM949_15525	COG0477	Major facilitator Superfamily
OM949_15545	COG0657	acetylesterase activity
OM949_15545	COG2755	lipolytic protein G-D-S-L family
OM949_15565	COG0488	(ABC) transporter
OM949_15595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OM949_15595	COG4651	solute:proton antiporter activity
OM949_15610	COG3328	transposase activity
OM949_15630	COG4772	TonB-dependent receptor
OM949_15640	COG4264	IucA IucC family
OM949_15655	COG0019	diaminopimelate decarboxylase activity
OM949_15685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OM949_15695	COG1492	cobalamin metabolic process
OM949_15705	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
OM949_15730	COG4206	TonB-dependent receptor
OM949_15740	COG0542	response to heat
OM949_15785	COG1877	trehalose-phosphatase activity
OM949_15790	COG3387	PFAM Glycoside hydrolase 15-related
OM949_15810	COG0840	transmembrane signaling receptor activity
OM949_15815	COG3011	Protein conserved in bacteria
OM949_15830	COG0564	pseudouridine synthase activity
OM949_15835	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OM949_15845	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OM949_15845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OM949_15855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OM949_15860	COG0045	succinate-CoA ligase (ADP-forming) activity
OM949_15905	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
OM949_15910	COG0237	dephospho-CoA kinase activity
OM949_15955	COG0745	RESPONSE REGULATOR receiver
OM949_15965	COG0189	ligase activity
OM949_15980	COG3328	transposase activity
OM949_16000	COG2801	Transposase and inactivated derivatives
OM949_16015	COG2003	Belongs to the UPF0758 family
OM949_16035	COG3328	transposase activity
OM949_16080	COG2022	thiamine diphosphate biosynthetic process
OM949_16090	COG0471	metal ion transport
OM949_16090	COG3273	potassium ion transport
OM949_16115	COG1970	mechanosensitive ion channel activity
OM949_16125	COG1609	Transcriptional regulator
OM949_16135	COG3250	beta-galactosidase activity
OM949_16140	COG4948	Mandelate Racemase Muconate Lactonizing
OM949_16150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OM949_16160	COG0308	aminopeptidase N
OM949_16165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OM949_16175	COG0529	Catalyzes the synthesis of activated sulfate
OM949_16175	COG2895	sulfate adenylyltransferase (ATP) activity
OM949_16180	COG0175	sulfate reduction
OM949_16185	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OM949_16190	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OM949_16195	COG0175	sulfate reduction
OM949_16215	COG2198	Histidine kinase
OM949_16215	COG0784	Response regulator, receiver
OM949_16215	COG2205	protein histidine kinase activity
OM949_16230	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OM949_16230	COG1648	precorrin-2 dehydrogenase activity
OM949_16245	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
OM949_16250	COG3588	fructose-bisphosphate aldolase
OM949_16255	COG0469	pyruvate kinase activity
OM949_16265	COG0126	phosphoglycerate kinase activity
OM949_16295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OM949_16305	COG3047	cAMP biosynthetic process
OM949_16320	COG3453	Protein conserved in bacteria
OM949_16320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OM949_16325	COG0725	ABC transporter, periplasmic molybdate-binding protein
OM949_16330	COG4149	molybdate abc transporter
OM949_16335	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OM949_16355	COG0642	Histidine kinase
OM949_16380	COG1022	Amp-dependent synthetase and ligase
OM949_16405	COG1376	ErfK ybiS ycfS ynhG family protein
OM949_16410	COG0739	heme binding
OM949_16415	COG4773	Receptor
OM949_16430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OM949_16435	COG1301	dicarboxylic acid transport
OM949_16445	COG2304	oxidoreductase activity
OM949_16465	COG0714	Associated with various cellular activities
OM949_16495	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
OM949_16515	COG1957	nucleoside hydrolase
OM949_16520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OM949_16530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OM949_16545	COG1561	YicC-like family, N-terminal region
OM949_16550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OM949_16560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OM949_16565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OM949_16580	COG0006	proline dipeptidase activity
OM949_16590	COG0006	proline dipeptidase activity
OM949_16595	COG3079	Belongs to the UPF0149 family
OM949_16615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OM949_16635	COG2912	Transglutaminase-like superfamily
OM949_16640	COG1773	rubredoxin
OM949_16645	COG0352	thiamine-phosphate diphosphorylase activity
OM949_16665	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OM949_16675	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
OM949_16680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OM949_16710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OM949_16715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OM949_16720	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_16730	COG0671	phosphoesterase, PA-phosphatase related
OM949_16740	COG3781	membrane
OM949_16750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OM949_16755	COG0563	adenylate kinase activity
OM949_16770	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
OM949_16780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OM949_16800	COG3710	Transcriptional regulator
OM949_16805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
OM949_16815	COG0840	transmembrane signaling receptor activity
OM949_16820	COG0405	Gamma-glutamyltransferase
OM949_16825	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OM949_16845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OM949_16850	COG0473	3-isopropylmalate dehydrogenase activity
OM949_16855	COG0066	3-isopropylmalate dehydratase activity
OM949_16860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OM949_16880	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OM949_16885	COG1538	Outer membrane efflux protein
OM949_16890	COG1519	Transferase
OM949_16895	COG1560	Kdo2-lipid A biosynthetic process
OM949_16920	COG0280	phosphate acetyltransferase
OM949_16920	COG0281	malic enzyme
OM949_16925	COG1301	dicarboxylic acid transport
OM949_16950	COG0583	DNA-binding transcription factor activity
OM949_16955	COG0667	Aldo Keto reductase
OM949_16970	COG2197	response regulator
OM949_16980	COG0642	Histidine kinase
OM949_16995	COG2851	Citrate transporter
OM949_17000	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_17005	COG1609	Transcriptional regulator
OM949_17010	COG2211	Major facilitator Superfamily
OM949_17035	COG1162	GTPase activity
OM949_17040	COG0436	Aminotransferase
OM949_17055	COG0726	polysaccharide deacetylase
OM949_17060	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OM949_17075	COG3964	amidohydrolase
OM949_17080	COG0402	S-adenosylhomocysteine deaminase activity
OM949_17105	COG3328	transposase activity
OM949_17115	COG1307	EDD domain protein, DegV family
OM949_17130	COG2801	Transposase and inactivated derivatives
OM949_17140	COG3791	Glutathione-dependent formaldehyde-activating
OM949_17170	COG2205	protein histidine kinase activity
OM949_17185	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OM949_17200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OM949_17210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OM949_17215	COG1012	belongs to the aldehyde dehydrogenase family
OM949_17220	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
OM949_17245	COG1183	phosphatidylcholine synthase activity
OM949_17255	COG0442	prolyl-tRNA aminoacylation
OM949_17270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OM949_17275	COG1127	ABC transporter
OM949_17280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OM949_17280	COG3218	ABC-type transport auxiliary lipoprotein component
OM949_17310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OM949_17315	COG0662	Cupin 2, conserved barrel domain protein
OM949_17315	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
OM949_17345	COG2086	electron transfer activity
OM949_17360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OM949_17360	COG0546	phosphoglycolate phosphatase activity
OM949_17365	COG0277	FAD linked oxidase domain protein
OM949_17375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OM949_17400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OM949_17405	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
OM949_17410	COG0438	transferase activity, transferring glycosyl groups
OM949_17430	COG0438	transferase activity, transferring glycosyl groups
OM949_17435	COG0626	cystathionine gamma-synthase activity
OM949_17465	COG0625	glutathione transferase activity
OM949_17475	COG0513	Belongs to the DEAD box helicase family
OM949_17480	COG0720	synthase
OM949_17490	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
OM949_17500	COG1956	GAF domain-containing protein
OM949_17515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OM949_17520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OM949_17530	COG4991	sh3 domain protein
OM949_17540	COG0339	signal peptide processing
OM949_17555	COG2132	Multicopper oxidase
OM949_17590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OM949_17595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OM949_17600	COG1136	(ABC) transporter
OM949_17605	COG0577	efflux transmembrane transporter activity
OM949_17605	COG1136	(ABC) transporter
OM949_17625	COG4191	Histidine kinase
OM949_17630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OM949_17655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OM949_17660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OM949_17665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OM949_17670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OM949_17675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OM949_17690	COG0356	it plays a direct role in the translocation of protons across the membrane
OM949_17710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OM949_17720	COG0508	dehydrogenase complex catalyzes the overall conversion of
OM949_17755	COG2011	ABC-type metal ion transport system permease component
OM949_17760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OM949_17765	COG0697	spore germination
OM949_17770	COG1666	GTP binding
OM949_17780	COG2198	Histidine kinase
OM949_17780	COG0784	Response regulator, receiver
OM949_17780	COG5002	protein histidine kinase activity
OM949_17805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OM949_17810	COG1187	pseudouridine synthase activity
OM949_17815	COG2813	Specifically methylates the guanine in position
OM949_17830	COG3039	Transposase
OM949_17860	COG2202	Pas domain
OM949_17860	COG2205	protein histidine kinase activity
OM949_17880	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OM949_17885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OM949_17940	COG0842	Transport permease protein
OM949_17945	COG1131	(ABC) transporter
OM949_17950	COG0025	NhaP-type Na H and K H
OM949_17955	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
OM949_17960	COG1573	uracil-dna glycosylase
OM949_17970	COG3384	dioxygenase
OM949_17980	COG0583	DNA-binding transcription factor activity
OM949_17990	COG0667	Aldo Keto reductase
OM949_18005	COG3590	peptidase
OM949_18025	COG0531	amino acid
OM949_18040	COG2972	Histidine kinase
OM949_18055	COG3685	Protein conserved in bacteria
OM949_18060	COG3546	catalase activity
OM949_18110	COG1271	oxidase subunit
OM949_18115	COG1294	oxidase, subunit
OM949_18130	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_18150	COG1063	alcohol dehydrogenase
OM949_18160	COG3328	transposase activity
OM949_18230	COG0251	oxidation-reduction process
OM949_18260	COG0659	secondary active sulfate transmembrane transporter activity
OM949_18265	COG0038	chloride channel
OM949_18275	COG0024	Methionine aminopeptidase
OM949_18290	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_18310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OM949_18315	COG1490	D-aminoacyl-tRNA deacylase activity
OM949_18320	COG1560	Kdo2-lipid A biosynthetic process
OM949_18365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OM949_18365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OM949_18370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OM949_18375	COG0242	peptide deformylase activity
OM949_18380	COG1652	LysM domain
OM949_18385	COG0758	DNA mediated transformation
OM949_18405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OM949_18405	COG1754	DNA topoisomerase type I activity
OM949_18410	COG0009	L-threonylcarbamoyladenylate synthase
OM949_18425	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_18435	COG0616	signal peptide processing
OM949_18440	COG0534	Mate efflux family protein
OM949_18460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OM949_18465	COG0625	glutathione transferase activity
OM949_18480	COG1252	NADH dehydrogenase
OM949_18485	COG2860	membrane
OM949_18490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OM949_18495	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
OM949_18500	COG2201	protein-glutamate methylesterase activity
OM949_18505	COG2177	Part of the ABC transporter FtsEX involved in
OM949_18510	COG2884	Cell division ATP-binding protein ftsE
OM949_18515	COG0513	Belongs to the DEAD box helicase family
OM949_18520	COG3118	belongs to the thioredoxin family
OM949_18525	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
OM949_18535	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
OM949_18560	COG1652	LysM domain
OM949_18565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OM949_18565	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OM949_18570	COG1473	amidohydrolase
OM949_18575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OM949_18580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OM949_18600	COG5383	Protein conserved in bacteria
OM949_18640	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
OM949_18645	COG3023	N-Acetylmuramoyl-L-alanine amidase
OM949_18665	COG0531	amino acid
OM949_18685	COG3328	transposase activity
OM949_18695	COG2133	pyrroloquinoline quinone binding
OM949_18705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OM949_18710	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OM949_18725	COG1610	YqeY-like protein
OM949_18730	COG1295	ribonuclease BN
OM949_18735	COG0358	DNA primase activity
OM949_18750	COG0109	protoheme IX farnesyltransferase activity
OM949_18780	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
OM949_18795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OM949_18835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OM949_18840	COG0739	heme binding
OM949_18845	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OM949_18855	COG2223	nitrite transmembrane transporter activity
OM949_18860	COG0708	Exodeoxyribonuclease III
OM949_18865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OM949_18875	COG1192	Involved in chromosome partitioning
OM949_18880	COG1475	DNA binding
OM949_18895	COG0463	Glycosyl transferase, family 2
OM949_18915	COG0756	dUTP diphosphatase activity
OM949_18920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OM949_18925	COG2003	Belongs to the UPF0758 family
OM949_18930	COG0018	arginyl-trna synthetase
OM949_18945	COG4221	oxidoreductase activity
OM949_18950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
OM949_18950	COG2755	lipolytic protein G-D-S-L family
OM949_18960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OM949_18965	COG1166	arginine decarboxylase activity
OM949_18970	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
OM949_18990	COG3291	Pkd domain containing protein
OM949_18990	COG3525	Glycosyl hydrolase, family 20, catalytic domain
OM949_19005	COG0606	chelatase, subunit chli
OM949_19020	COG4943	cyclic-guanylate-specific phosphodiesterase activity
OM949_19045	COG1690	Belongs to the RtcB family
OM949_19085	COG1090	epimerase
OM949_19095	COG0642	Histidine kinase
OM949_19115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OM949_19140	COG1011	Hydrolase
OM949_19145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OM949_19160	COG0753	catalase activity
OM949_19175	COG2197	response regulator
OM949_19180	COG4585	Histidine kinase
OM949_19185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OM949_19190	COG1136	(ABC) transporter
OM949_19215	COG0697	spore germination
OM949_19240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OM949_19245	COG0180	Tryptophanyl-tRNA synthetase
OM949_19250	COG3237	CsbD-like
OM949_19290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OM949_19305	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
OM949_19310	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
OM949_19310	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
OM949_19320	COG3228	Belongs to the MtfA family
OM949_19350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OM949_19390	COG3328	transposase activity
OM949_19405	COG1199	ATP-dependent helicase activity
OM949_19420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OM949_19510	COG4555	ABC transporter
OM949_19520	COG1476	TRANSCRIPTIONal
OM949_19540	COG1230	cation diffusion facilitator family transporter
OM949_19545	COG0633	Ferredoxin
OM949_19545	COG0543	2 iron, 2 sulfur cluster binding
OM949_19550	COG1131	(ABC) transporter
OM949_19555	COG0842	Transport permease protein
OM949_19560	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OM949_19585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OM949_19605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OM949_19610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OM949_19620	COG1042	CoA-binding domain protein
OM949_19620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OM949_19620	COG0045	succinate-CoA ligase (ADP-forming) activity
OM949_19625	COG2239	Acts as a magnesium transporter
OM949_19645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OM949_19650	COG3387	PFAM Glycoside hydrolase 15-related
OM949_19665	COG3100	YcgL domain-containing protein
OM949_19670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OM949_19680	COG0463	Glycosyl transferase, family 2
OM949_19690	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_19745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OM949_19780	COG0408	coproporphyrinogen oxidase activity
OM949_19815	COG0515	serine threonine protein kinase
OM949_19820	COG0631	protein serine/threonine phosphatase activity
OM949_19845	COG0667	Aldo Keto reductase
OM949_19850	COG0583	DNA-binding transcription factor activity
OM949_19925	COG0154	amidase activity
OM949_19930	COG3039	Transposase
OM949_19940	COG3328	transposase activity
OM949_19965	COG3328	transposase activity
OM949_20045	COG0210	DNA helicase
OM949_20060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OM949_20065	COG0583	DNA-binding transcription factor activity
OM949_20070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OM949_20080	COG2159	amidohydrolase
OM949_20105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OM949_20125	COG0357	Ribosomal RNA small subunit methyltransferase G
OM949_20130	COG3540	Alkaline phosphatase
OM949_20140	COG2091	lysine biosynthetic process via aminoadipic acid
OM949_20155	COG0708	Exodeoxyribonuclease III
OM949_20160	COG1846	Transcriptional regulator
OM949_20160	COG1940	carbohydrate kinase activity
OM949_20170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OM949_20180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OM949_20185	COG3162	membrane
OM949_20195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OM949_20230	COG3507	Belongs to the glycosyl hydrolase 43 family
OM949_20250	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_20255	COG0179	Fumarylacetoacetate (FAA) hydrolase
OM949_20260	COG4948	Mandelate Racemase Muconate Lactonizing
OM949_20265	COG3254	rhamnose metabolic process
OM949_20270	COG0738	Major facilitator superfamily
OM949_20275	COG1414	Transcriptional regulator
OM949_20280	COG1917	Cupin 2, conserved barrel domain protein
OM949_20280	COG2207	Transcriptional regulator
OM949_20290	COG1971	Probably functions as a manganese efflux pump
OM949_20295	COG2205	protein histidine kinase activity
OM949_20305	COG3459	Glycosyltransferase 36 associated
OM949_20310	COG2211	Major facilitator Superfamily
OM949_20315	COG3265	gluconokinase activity
OM949_20320	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OM949_20340	COG2911	Protein conserved in bacteria
OM949_20345	COG0729	surface antigen
OM949_20350	COG4771	TonB-dependent receptor
OM949_20355	COG0457	Tetratricopeptide repeat
OM949_20365	COG0752	glycyl-tRNA synthetase alpha subunit
OM949_20370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OM949_20385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OM949_20385	COG0519	Catalyzes the synthesis of GMP from XMP
OM949_20400	COG0805	protein transport
OM949_20405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OM949_20410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OM949_20420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OM949_20440	COG2974	May be involved in recombination
OM949_20445	COG0037	tRNA processing
OM949_20450	COG2115	Belongs to the xylose isomerase family
OM949_20465	COG3661	Belongs to the glycosyl hydrolase 67 family
OM949_20475	COG4948	Mandelate Racemase Muconate Lactonizing
OM949_20485	COG1472	Belongs to the glycosyl hydrolase 3 family
OM949_20490	COG0246	Mannitol dehydrogenase
OM949_20545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OM949_20570	COG3386	PFAM SMP-30 Gluconolaconase
OM949_20580	COG3250	beta-galactosidase activity
OM949_20585	COG1904	glucuronate isomerase
OM949_20590	COG3693	PFAM glycoside hydrolase, family 10
OM949_20605	COG3693	PFAM glycoside hydrolase, family 10
OM949_20620	COG2211	Major facilitator Superfamily
OM949_20650	COG3039	Transposase
OM949_20675	COG3328	transposase activity
OM949_20720	COG2937	Belongs to the GPAT DAPAT family
OM949_20750	COG0284	orotidine-5'-phosphate decarboxylase activity
OM949_20755	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
OM949_20770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OM949_20820	COG0210	DNA helicase
OM949_20825	COG1435	thymidine kinase activity
OM949_20835	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
OM949_20845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OM949_20875	COG3135	benzoate transporter
OM949_20900	COG0676	glucose-6-phosphate 1-epimerase activity
OM949_20910	COG3012	SEC-C Motif Domain Protein
OM949_20950	COG3328	transposase activity
OM949_20970	COG3039	Transposase
OM949_21020	COG0730	response to heat
OM949_21030	COG3328	transposase activity
OM949_21050	COG0302	gtp cyclohydrolase
OM949_21065	COG1566	PFAM secretion protein HlyD family protein
OM949_21075	COG1289	transmembrane transporter activity
OM949_21080	COG0477	Major facilitator Superfamily
OM949_21090	COG0583	DNA-binding transcription factor activity
OM949_21095	COG4221	oxidoreductase activity
OM949_21105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OM949_21130	COG3328	transposase activity
OM949_21155	COG0564	pseudouridine synthase activity
OM949_21185	COG3012	SEC-C Motif Domain Protein
OM949_21255	COG4790	Type iii secretion
OM949_21420	COG3039	Transposase
OM949_21460	COG2801	Transposase and inactivated derivatives
OM949_21520	COG0439	Biotin carboxylase
OM949_21545	COG1028	Short-chain dehydrogenase reductase Sdr
OM949_21595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OM949_21600	COG1074	ATP-dependent DNA helicase activity
OM949_21605	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OM949_21640	COG1127	ABC transporter
OM949_21645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OM949_21650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OM949_21665	COG2853	Lipoprotein
OM949_21675	COG0386	Belongs to the glutathione peroxidase family
OM949_21685	COG1322	Protein conserved in bacteria
OM949_21695	COG0583	DNA-binding transcription factor activity
OM949_21715	COG0531	amino acid
OM949_21720	COG3537	Alpha-1,2-mannosidase
OM949_21740	COG2203	Gaf domain
OM949_21740	COG2199	diguanylate cyclase activity
OM949_21745	COG3835	regulator
OM949_21750	COG1929	Belongs to the glycerate kinase type-1 family
OM949_21770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OM949_21775	COG0861	Integral membrane protein TerC family
OM949_21785	COG0584	glycerophosphoryl diester phosphodiesterase
OM949_21800	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OM949_21805	COG0726	polysaccharide deacetylase
OM949_21815	COG0706	membrane insertase activity
OM949_21820	COG0594	ribonuclease P activity
OM949_21880	COG2951	lytic endotransglycosylase activity
OM949_21895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OM949_21895	COG0551	DNA topoisomerase type I activity
OM949_21930	COG3846	protein secretion by the type IV secretion system
OM949_21950	COG3451	type IV secretory pathway VirB4
OM949_21955	COG3451	type IV secretory pathway VirB4
OM949_21970	COG4962	Type ii secretion system protein e
OM949_22075	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OM949_22080	COG4691	Plasmid stability protein
OM949_22085	COG1487	ribonuclease activity
OM949_22175	COG3328	transposase activity
OM949_22245	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OM949_22300	COG2801	Transposase and inactivated derivatives
OM949_22365	COG3039	Transposase
OM949_22480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OM949_22485	COG4691	Plasmid stability protein
OM949_22490	COG1487	ribonuclease activity