locus-tag	class	description
DGM85_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DGM85_00025	COG0187	DNA topoisomerase II activity
DGM85_00035	COG0501	Belongs to the peptidase M48B family
DGM85_00105	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_00110	COG0300	oxidoreductase activity
DGM85_00130	COG1272	protein, Hemolysin III
DGM85_00135	COG1111	helicase
DGM85_00135	COG1205	dead DEAH box helicase
DGM85_00225	COG0067	glutamate synthase
DGM85_00225	COG0069	glutamate synthase activity
DGM85_00225	COG0070	glutamate synthase
DGM85_00230	COG0493	'glutamate synthase
DGM85_00245	COG1064	alcohol dehydrogenase
DGM85_00255	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGM85_00265	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGM85_00270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGM85_00280	COG2234	aminopeptidase activity
DGM85_00290	COG4942	peptidase
DGM85_00295	COG0793	Belongs to the peptidase S41A family
DGM85_00340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGM85_00350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DGM85_00385	COG3039	Transposase
DGM85_00400	COG3039	Transposase
DGM85_00405	COG3237	CsbD-like
DGM85_00450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGM85_00460	COG0477	Major facilitator Superfamily
DGM85_00500	COG0714	Associated with various cellular activities
DGM85_00545	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DGM85_00555	COG4772	TonB-dependent receptor
DGM85_00585	COG1304	FMN binding
DGM85_00590	COG1755	Isoprenylcysteine carboxyl methyltransferase
DGM85_00595	COG4585	Histidine kinase
DGM85_00600	COG2197	response regulator
DGM85_00630	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DGM85_00675	COG3328	transposase activity
DGM85_00685	COG0730	response to heat
DGM85_00705	COG3039	Transposase
DGM85_00730	COG3328	transposase activity
DGM85_00735	COG3012	SEC-C Motif Domain Protein
DGM85_00745	COG0676	glucose-6-phosphate 1-epimerase activity
DGM85_00775	COG3135	benzoate transporter
DGM85_00805	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DGM85_00815	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DGM85_00825	COG1435	thymidine kinase activity
DGM85_00830	COG0210	DNA helicase
DGM85_00880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DGM85_00895	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DGM85_00900	COG0284	orotidine-5'-phosphate decarboxylase activity
DGM85_00935	COG2937	Belongs to the GPAT DAPAT family
DGM85_00975	COG3328	transposase activity
DGM85_00990	COG2211	Major facilitator Superfamily
DGM85_01005	COG3693	PFAM glycoside hydrolase, family 10
DGM85_01015	COG3039	Transposase
DGM85_01020	COG3693	PFAM glycoside hydrolase, family 10
DGM85_01025	COG1904	glucuronate isomerase
DGM85_01040	COG3386	PFAM SMP-30 Gluconolaconase
DGM85_01065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DGM85_01130	COG0246	Mannitol dehydrogenase
DGM85_01145	COG4948	Mandelate Racemase Muconate Lactonizing
DGM85_01155	COG3661	Belongs to the glycosyl hydrolase 67 family
DGM85_01165	COG2115	Belongs to the xylose isomerase family
DGM85_01175	COG0037	tRNA processing
DGM85_01180	COG2974	May be involved in recombination
DGM85_01200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DGM85_01210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGM85_01215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGM85_01220	COG0805	protein transport
DGM85_01235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGM85_01235	COG0519	Catalyzes the synthesis of GMP from XMP
DGM85_01250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGM85_01255	COG0752	glycyl-tRNA synthetase alpha subunit
DGM85_01265	COG0457	Tetratricopeptide repeat
DGM85_01275	COG4771	TonB-dependent receptor
DGM85_01280	COG0729	surface antigen
DGM85_01285	COG2911	Protein conserved in bacteria
DGM85_01305	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGM85_01315	COG3265	gluconokinase activity
DGM85_01320	COG2211	Major facilitator Superfamily
DGM85_01325	COG3459	Glycosyltransferase 36 associated
DGM85_01340	COG2205	protein histidine kinase activity
DGM85_01345	COG1971	Probably functions as a manganese efflux pump
DGM85_01355	COG1917	Cupin 2, conserved barrel domain protein
DGM85_01355	COG2207	Transcriptional regulator
DGM85_01360	COG1414	Transcriptional regulator
DGM85_01365	COG0738	Major facilitator superfamily
DGM85_01370	COG3254	rhamnose metabolic process
DGM85_01375	COG4948	Mandelate Racemase Muconate Lactonizing
DGM85_01380	COG0179	Fumarylacetoacetate (FAA) hydrolase
DGM85_01385	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_01405	COG3507	Belongs to the glycosyl hydrolase 43 family
DGM85_01440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DGM85_01450	COG3162	membrane
DGM85_01455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DGM85_01465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGM85_01475	COG1846	Transcriptional regulator
DGM85_01475	COG1940	carbohydrate kinase activity
DGM85_01480	COG0708	Exodeoxyribonuclease III
DGM85_01495	COG2091	lysine biosynthetic process via aminoadipic acid
DGM85_01505	COG3540	Alkaline phosphatase
DGM85_01510	COG0357	Ribosomal RNA small subunit methyltransferase G
DGM85_01535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM85_01540	COG3328	transposase activity
DGM85_01570	COG2159	amidohydrolase
DGM85_01585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGM85_01590	COG0583	DNA-binding transcription factor activity
DGM85_01595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGM85_01610	COG0210	DNA helicase
DGM85_01695	COG3328	transposase activity
DGM85_01720	COG0154	amidase activity
DGM85_01795	COG0583	DNA-binding transcription factor activity
DGM85_01800	COG0667	Aldo Keto reductase
DGM85_01825	COG0631	protein serine/threonine phosphatase activity
DGM85_01870	COG0408	coproporphyrinogen oxidase activity
DGM85_01920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGM85_01935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGM85_01980	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_01990	COG0463	Glycosyl transferase, family 2
DGM85_02000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DGM85_02005	COG3100	YcgL domain-containing protein
DGM85_02020	COG3387	PFAM Glycoside hydrolase 15-related
DGM85_02025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGM85_02055	COG3338	carbonate dehydratase activity
DGM85_02065	COG2239	Acts as a magnesium transporter
DGM85_02070	COG0045	succinate-CoA ligase (ADP-forming) activity
DGM85_02070	COG1042	CoA-binding domain protein
DGM85_02070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DGM85_02085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGM85_02090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGM85_02110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGM85_02145	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DGM85_02150	COG0842	Transport permease protein
DGM85_02155	COG1131	(ABC) transporter
DGM85_02165	COG0633	Ferredoxin
DGM85_02165	COG0543	2 iron, 2 sulfur cluster binding
DGM85_02170	COG1230	cation diffusion facilitator family transporter
DGM85_02190	COG1476	TRANSCRIPTIONal
DGM85_02200	COG4555	ABC transporter
DGM85_02285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DGM85_02300	COG1199	ATP-dependent helicase activity
DGM85_02360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGM85_02390	COG3228	Belongs to the MtfA family
DGM85_02405	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DGM85_02405	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DGM85_02410	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DGM85_02425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DGM85_02470	COG3237	CsbD-like
DGM85_02475	COG0180	Tryptophanyl-tRNA synthetase
DGM85_02480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGM85_02505	COG0697	spore germination
DGM85_02530	COG1136	(ABC) transporter
DGM85_02535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM85_02540	COG4585	Histidine kinase
DGM85_02545	COG2197	response regulator
DGM85_02560	COG0753	catalase activity
DGM85_02575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGM85_02580	COG1011	Hydrolase
DGM85_02605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGM85_02625	COG0642	Histidine kinase
DGM85_02635	COG1090	epimerase
DGM85_02675	COG1690	Belongs to the RtcB family
DGM85_02710	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DGM85_02725	COG0606	chelatase, subunit chli
DGM85_02745	COG3291	Pkd domain containing protein
DGM85_02745	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DGM85_02765	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DGM85_02770	COG1166	arginine decarboxylase activity
DGM85_02775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGM85_02785	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DGM85_02785	COG2755	lipolytic protein G-D-S-L family
DGM85_02790	COG4221	oxidoreductase activity
DGM85_02805	COG0018	arginyl-trna synthetase
DGM85_02810	COG2003	Belongs to the UPF0758 family
DGM85_02815	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DGM85_02820	COG0756	dUTP diphosphatase activity
DGM85_02840	COG0463	Glycosyl transferase, family 2
DGM85_02855	COG1475	DNA binding
DGM85_02860	COG1192	Involved in chromosome partitioning
DGM85_02870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DGM85_02875	COG0708	Exodeoxyribonuclease III
DGM85_02880	COG2211	Major facilitator Superfamily
DGM85_02890	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DGM85_02900	COG0739	heme binding
DGM85_02905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DGM85_02945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DGM85_02960	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DGM85_02990	COG0109	protoheme IX farnesyltransferase activity
DGM85_03005	COG0358	DNA primase activity
DGM85_03010	COG1295	ribonuclease BN
DGM85_03020	COG1610	YqeY-like protein
DGM85_03030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DGM85_03035	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DGM85_03045	COG2133	pyrroloquinoline quinone binding
DGM85_03050	COG4682	membrane
DGM85_03065	COG0531	amino acid
DGM85_03075	COG4948	Mandelate Racemase Muconate Lactonizing
DGM85_03085	COG3023	N-Acetylmuramoyl-L-alanine amidase
DGM85_03090	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DGM85_03125	COG5383	Protein conserved in bacteria
DGM85_03135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM85_03140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM85_03145	COG1473	amidohydrolase
DGM85_03150	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGM85_03150	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGM85_03155	COG1652	LysM domain
DGM85_03180	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DGM85_03190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DGM85_03195	COG3118	belongs to the thioredoxin family
DGM85_03205	COG2884	Cell division ATP-binding protein ftsE
DGM85_03210	COG2177	Part of the ABC transporter FtsEX involved in
DGM85_03215	COG3437	response regulator, receiver
DGM85_03220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DGM85_03225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGM85_03230	COG2860	membrane
DGM85_03235	COG1252	NADH dehydrogenase
DGM85_03250	COG0625	glutathione transferase activity
DGM85_03255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DGM85_03275	COG0534	Mate efflux family protein
DGM85_03280	COG0616	signal peptide processing
DGM85_03290	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_03305	COG0009	L-threonylcarbamoyladenylate synthase
DGM85_03310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGM85_03310	COG1754	DNA topoisomerase type I activity
DGM85_03330	COG0758	DNA mediated transformation
DGM85_03335	COG1652	LysM domain
DGM85_03340	COG0242	peptide deformylase activity
DGM85_03345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DGM85_03350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DGM85_03350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGM85_03395	COG1560	Kdo2-lipid A biosynthetic process
DGM85_03400	COG1490	D-aminoacyl-tRNA deacylase activity
DGM85_03405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGM85_03440	COG0024	Methionine aminopeptidase
DGM85_03450	COG0038	chloride channel
DGM85_03455	COG0659	secondary active sulfate transmembrane transporter activity
DGM85_03480	COG0251	oxidation-reduction process
DGM85_03555	COG1063	alcohol dehydrogenase
DGM85_03575	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_03590	COG1294	oxidase, subunit
DGM85_03595	COG1271	oxidase subunit
DGM85_03645	COG3546	catalase activity
DGM85_03650	COG3685	Protein conserved in bacteria
DGM85_03670	COG2972	Histidine kinase
DGM85_03685	COG0531	amino acid
DGM85_03700	COG3590	peptidase
DGM85_03715	COG0667	Aldo Keto reductase
DGM85_03725	COG0583	DNA-binding transcription factor activity
DGM85_03735	COG3384	dioxygenase
DGM85_03745	COG1573	uracil-dna glycosylase
DGM85_03750	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DGM85_03760	COG0025	NhaP-type Na H and K H
DGM85_03765	COG1131	(ABC) transporter
DGM85_03770	COG0842	Transport permease protein
DGM85_03825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM85_03830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DGM85_03850	COG2205	protein histidine kinase activity
DGM85_03850	COG2202	Pas domain
DGM85_03865	COG3328	transposase activity
DGM85_03880	COG3039	Transposase
DGM85_03885	COG2813	Specifically methylates the guanine in position
DGM85_03890	COG1187	pseudouridine synthase activity
DGM85_03895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DGM85_03920	COG5002	protein histidine kinase activity
DGM85_03920	COG2198	Histidine kinase
DGM85_03920	COG0784	Response regulator, receiver
DGM85_03930	COG1666	GTP binding
DGM85_03935	COG0697	spore germination
DGM85_03940	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DGM85_03945	COG2011	ABC-type metal ion transport system permease component
DGM85_03985	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGM85_03995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGM85_04015	COG0356	it plays a direct role in the translocation of protons across the membrane
DGM85_04030	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DGM85_04035	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DGM85_04040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DGM85_04045	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DGM85_04050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DGM85_04065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DGM85_04070	COG4191	Histidine kinase
DGM85_04090	COG1136	(ABC) transporter
DGM85_04090	COG0577	efflux transmembrane transporter activity
DGM85_04095	COG1136	(ABC) transporter
DGM85_04100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM85_04105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGM85_04140	COG2132	Multicopper oxidase
DGM85_04155	COG0339	signal peptide processing
DGM85_04165	COG4991	sh3 domain protein
DGM85_04175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGM85_04180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DGM85_04195	COG1956	GAF domain-containing protein
DGM85_04205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DGM85_04215	COG0720	synthase
DGM85_04220	COG0513	Belongs to the DEAD box helicase family
DGM85_04235	COG0625	glutathione transferase activity
DGM85_04265	COG0626	cystathionine gamma-synthase activity
DGM85_04275	COG0438	transferase activity, transferring glycosyl groups
DGM85_04295	COG0438	transferase activity, transferring glycosyl groups
DGM85_04300	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DGM85_04305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGM85_04325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGM85_04335	COG0277	FAD linked oxidase domain protein
DGM85_04340	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DGM85_04340	COG0546	phosphoglycolate phosphatase activity
DGM85_04355	COG2086	electron transfer activity
DGM85_04385	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DGM85_04385	COG0662	Cupin 2, conserved barrel domain protein
DGM85_04390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGM85_04420	COG3218	ABC-type transport auxiliary lipoprotein component
DGM85_04420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGM85_04425	COG1127	ABC transporter
DGM85_04430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGM85_04445	COG0442	prolyl-tRNA aminoacylation
DGM85_04455	COG1183	phosphatidylcholine synthase activity
DGM85_04480	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DGM85_04485	COG1012	belongs to the aldehyde dehydrogenase family
DGM85_04490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DGM85_04500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGM85_04515	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DGM85_04530	COG2205	protein histidine kinase activity
DGM85_04560	COG3791	Glutathione-dependent formaldehyde-activating
DGM85_04585	COG1307	EDD domain protein, DegV family
DGM85_04620	COG0402	S-adenosylhomocysteine deaminase activity
DGM85_04625	COG3964	amidohydrolase
DGM85_04640	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGM85_04645	COG0726	polysaccharide deacetylase
DGM85_04660	COG0436	Aminotransferase
DGM85_04665	COG1162	GTPase activity
DGM85_04690	COG2211	Major facilitator Superfamily
DGM85_04695	COG1609	Transcriptional regulator
DGM85_04700	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_04705	COG2851	Citrate transporter
DGM85_04725	COG0642	Histidine kinase
DGM85_04740	COG2197	response regulator
DGM85_04755	COG0667	Aldo Keto reductase
DGM85_04760	COG0583	DNA-binding transcription factor activity
DGM85_04795	COG1301	dicarboxylic acid transport
DGM85_04800	COG0280	phosphate acetyltransferase
DGM85_04800	COG0281	malic enzyme
DGM85_04825	COG1560	Kdo2-lipid A biosynthetic process
DGM85_04830	COG1519	Transferase
DGM85_04835	COG1538	Outer membrane efflux protein
DGM85_04840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGM85_04860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DGM85_04865	COG0066	3-isopropylmalate dehydratase activity
DGM85_04870	COG0473	3-isopropylmalate dehydrogenase activity
DGM85_04880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DGM85_04900	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DGM85_04905	COG0405	Gamma-glutamyltransferase
DGM85_04910	COG0840	transmembrane signaling receptor activity
DGM85_04925	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DGM85_04930	COG3710	Transcriptional regulator
DGM85_04950	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DGM85_04960	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DGM85_04975	COG0563	adenylate kinase activity
DGM85_04980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGM85_04990	COG3781	membrane
DGM85_05000	COG0671	phosphoesterase, PA-phosphatase related
DGM85_05010	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_05015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGM85_05020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DGM85_05055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGM85_05060	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
DGM85_05070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DGM85_05110	COG0352	thiamine-phosphate diphosphorylase activity
DGM85_05115	COG1773	rubredoxin
DGM85_05125	COG2912	Transglutaminase-like superfamily
DGM85_05145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DGM85_05165	COG3079	Belongs to the UPF0149 family
DGM85_05170	COG0006	proline dipeptidase activity
DGM85_05180	COG0006	proline dipeptidase activity
DGM85_05195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DGM85_05200	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DGM85_05210	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DGM85_05215	COG1561	YicC-like family, N-terminal region
DGM85_05230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGM85_05240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DGM85_05245	COG1957	nucleoside hydrolase
DGM85_05265	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DGM85_05295	COG0714	Associated with various cellular activities
DGM85_05315	COG2304	oxidoreductase activity
DGM85_05325	COG1301	dicarboxylic acid transport
DGM85_05330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DGM85_05345	COG4773	Receptor
DGM85_05350	COG0739	heme binding
DGM85_05355	COG1376	ErfK ybiS ycfS ynhG family protein
DGM85_05380	COG1022	Amp-dependent synthetase and ligase
DGM85_05425	COG0642	Histidine kinase
DGM85_05445	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DGM85_05450	COG4149	molybdate abc transporter
DGM85_05455	COG0725	ABC transporter, periplasmic molybdate-binding protein
DGM85_05460	COG3453	Protein conserved in bacteria
DGM85_05460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGM85_05475	COG3047	cAMP biosynthetic process
DGM85_05485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DGM85_05515	COG0126	phosphoglycerate kinase activity
DGM85_05525	COG0469	pyruvate kinase activity
DGM85_05535	COG3588	fructose-bisphosphate aldolase
DGM85_05540	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DGM85_05555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGM85_05555	COG1648	precorrin-2 dehydrogenase activity
DGM85_05575	COG0784	Response regulator, receiver
DGM85_05575	COG2198	Histidine kinase
DGM85_05575	COG2205	protein histidine kinase activity
DGM85_05595	COG0175	sulfate reduction
DGM85_05600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DGM85_05605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGM85_05610	COG0175	sulfate reduction
DGM85_05615	COG0529	Catalyzes the synthesis of activated sulfate
DGM85_05615	COG2895	sulfate adenylyltransferase (ATP) activity
DGM85_05625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM85_05630	COG0308	aminopeptidase N
DGM85_05640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGM85_05650	COG4948	Mandelate Racemase Muconate Lactonizing
DGM85_05665	COG1609	Transcriptional regulator
DGM85_05675	COG1970	mechanosensitive ion channel activity
DGM85_05700	COG0471	metal ion transport
DGM85_05700	COG3273	potassium ion transport
DGM85_05705	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DGM85_05710	COG2022	thiamine diphosphate biosynthetic process
DGM85_05735	COG3039	Transposase
DGM85_05775	COG1002	Type II restriction enzyme, methylase subunits
DGM85_05780	COG1061	Type III restriction enzyme res subunit
DGM85_05785	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DGM85_05800	COG3328	transposase activity
DGM85_05815	COG3039	Transposase
DGM85_05840	COG3328	transposase activity
DGM85_05850	COG3692	DNA binding
DGM85_05875	COG0322	excinuclease ABC activity
DGM85_05880	COG3328	transposase activity
DGM85_05945	COG3328	transposase activity
DGM85_05960	COG0189	ligase activity
DGM85_05970	COG0745	RESPONSE REGULATOR receiver
DGM85_05995	COG0237	dephospho-CoA kinase activity
DGM85_06000	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DGM85_06050	COG0045	succinate-CoA ligase (ADP-forming) activity
DGM85_06055	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DGM85_06070	COG3328	transposase activity
DGM85_06080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGM85_06080	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DGM85_06090	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGM85_06095	COG0564	pseudouridine synthase activity
DGM85_06110	COG3011	Protein conserved in bacteria
DGM85_06115	COG0840	transmembrane signaling receptor activity
DGM85_06145	COG3387	PFAM Glycoside hydrolase 15-related
DGM85_06150	COG1877	trehalose-phosphatase activity
DGM85_06200	COG0542	response to heat
DGM85_06210	COG4206	TonB-dependent receptor
DGM85_06230	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGM85_06240	COG1492	cobalamin metabolic process
DGM85_06250	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DGM85_06270	COG3328	transposase activity
DGM85_06285	COG3328	transposase activity
DGM85_06290	COG0019	diaminopimelate decarboxylase activity
DGM85_06305	COG4264	IucA IucC family
DGM85_06315	COG4772	TonB-dependent receptor
DGM85_06340	COG4651	solute:proton antiporter activity
DGM85_06340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGM85_06375	COG0488	(ABC) transporter
DGM85_06395	COG2755	lipolytic protein G-D-S-L family
DGM85_06395	COG0657	acetylesterase activity
DGM85_06420	COG0477	Major facilitator Superfamily
DGM85_06435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DGM85_06450	COG0217	transcriptional regulatory protein
DGM85_06455	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DGM85_06460	COG0632	four-way junction helicase activity
DGM85_06465	COG3158	transport of potassium into the cell
DGM85_06475	COG2255	four-way junction helicase activity
DGM85_06480	COG0824	Thioesterase
DGM85_06490	COG0848	biopolymer transport protein
DGM85_06500	COG0823	Involved in the tonB-independent uptake of proteins
DGM85_06505	COG2885	chlorophyll binding
DGM85_06515	COG0602	queuosine metabolic process
DGM85_06525	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DGM85_06530	COG3920	Histidine kinase
DGM85_06550	COG3328	transposase activity
DGM85_06560	COG0840	transmembrane signaling receptor activity
DGM85_06605	COG0514	ATP-dependent DNA helicase (RecQ)
DGM85_06610	COG0783	Belongs to the Dps family
DGM85_06615	COG1643	Atp-dependent helicase
DGM85_06645	COG0837	glucose binding
DGM85_06660	COG0535	radical SAM domain protein
DGM85_06665	COG0535	radical SAM domain protein
DGM85_06670	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DGM85_06675	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DGM85_06685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGM85_06705	COG1215	transferase activity, transferring glycosyl groups
DGM85_06710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGM85_06720	COG1199	ATP-dependent helicase activity
DGM85_06730	COG1397	ADP-ribosylglycohydrolase
DGM85_06740	COG0189	ligase activity
DGM85_06755	COG0835	chemotaxis
DGM85_06760	COG0840	transmembrane signaling receptor activity
DGM85_06765	COG0643	Histidine kinase
DGM85_06765	COG2198	Histidine kinase
DGM85_06765	COG0784	Response regulator, receiver
DGM85_06800	COG3142	Participates in the control of copper homeostasis
DGM85_06845	COG3537	Alpha-1,2-mannosidase
DGM85_06855	COG1472	Belongs to the glycosyl hydrolase 3 family
DGM85_06870	COG1388	LysM domain
DGM85_06870	COG3858	chitin binding
DGM85_06900	COG0837	glucose binding
DGM85_06905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DGM85_06915	COG0494	nUDIX hydrolase
DGM85_06925	COG3956	TIGRFAM MazG family protein
DGM85_06930	COG1742	UPF0060 membrane protein
DGM85_06935	COG0330	HflC and HflK could
DGM85_06945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DGM85_06950	COG0509	glycine decarboxylation via glycine cleavage system
DGM85_06985	COG3328	transposase activity
DGM85_07035	COG3250	beta-galactosidase activity
DGM85_07040	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DGM85_07060	COG1960	acyl-CoA dehydrogenase activity
DGM85_07090	COG0457	Tetratricopeptide repeat
DGM85_07100	COG0457	Tetratricopeptide repeat
DGM85_07110	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGM85_07110	COG1024	Enoyl-CoA hydratase
DGM85_07125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGM85_07135	COG0481	GTPase activity
DGM85_07150	COG0571	ribonuclease III activity
DGM85_07155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DGM85_07160	COG1381	Involved in DNA repair and RecF pathway recombination
DGM85_07170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DGM85_07175	COG2954	triphosphatase activity
DGM85_07180	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DGM85_07185	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DGM85_07190	COG3046	protein related to deoxyribodipyrimidine photolyase
DGM85_07195	COG1472	Belongs to the glycosyl hydrolase 3 family
DGM85_07200	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DGM85_07205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DGM85_07210	COG1278	Cold shock
DGM85_07215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGM85_07225	COG1201	RNA secondary structure unwinding
DGM85_07230	COG1793	dna ligase
DGM85_07240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DGM85_07240	COG1793	dna ligase
DGM85_07280	COG0183	Belongs to the thiolase family
DGM85_07300	COG1451	nucleotide metabolic process
DGM85_07305	COG5487	UPF0391 membrane protein
DGM85_07315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DGM85_07335	COG1077	Cell shape determining protein MreB Mrl
DGM85_07340	COG1047	Peptidyl-prolyl cis-trans
DGM85_07350	COG2824	Alkylphosphonate utilization operon protein PhnA
DGM85_07360	COG1902	pentaerythritol trinitrate reductase activity
DGM85_07365	COG2814	Major facilitator Superfamily
DGM85_07400	COG0392	lysyltransferase activity
DGM85_07400	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DGM85_07410	COG0251	oxidation-reduction process
DGM85_07415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGM85_07430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGM85_07455	COG1595	DNA-templated transcription, initiation
DGM85_07470	COG2878	Part of a membrane complex involved in electron transport
DGM85_07485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGM85_07485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGM85_07505	COG0346	lactoylglutathione lyase activity
DGM85_07520	COG0833	amino acid
DGM85_07525	COG2040	homocysteine
DGM85_07535	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGM85_07555	COG1695	Transcriptional regulator
DGM85_07575	COG1981	membrane
DGM85_07590	COG0825	malonyl-CoA metabolic process
DGM85_07605	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGM85_07610	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGM85_07615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGM85_07620	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGM85_07635	COG0750	zinc metalloprotease
DGM85_07640	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DGM85_07645	COG0575	Belongs to the CDS family
DGM85_07650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DGM85_07655	COG0233	cytoplasmic translational termination
DGM85_07660	COG0528	UMP kinase activity
DGM85_07670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DGM85_07675	COG0052	Belongs to the universal ribosomal protein uS2 family
DGM85_07715	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DGM85_07725	COG1393	Belongs to the ArsC family
DGM85_07730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGM85_07735	COG0367	asparagine synthase
DGM85_07745	COG4774	siderophore transport
DGM85_07765	COG3328	transposase activity
DGM85_07795	COG3328	transposase activity
DGM85_07835	COG1566	PFAM secretion protein HlyD family protein
DGM85_07840	COG2814	Major facilitator Superfamily
DGM85_07870	COG3104	oligopeptide transport
DGM85_07900	COG0339	signal peptide processing
DGM85_07905	COG0386	Belongs to the glutathione peroxidase family
DGM85_07965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DGM85_07970	COG0084	hydrolase, TatD family'
DGM85_07985	COG1960	acyl-CoA dehydrogenase activity
DGM85_08005	COG0367	asparagine synthase
DGM85_08015	COG0305	Participates in initiation and elongation during chromosome replication
DGM85_08020	COG0415	Belongs to the DNA photolyase family
DGM85_08035	COG0583	DNA-binding transcription factor activity
DGM85_08080	COG3706	GGDEF domain
DGM85_08100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DGM85_08115	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGM85_08125	COG0497	DNA recombination
DGM85_08130	COG1420	regulation of RNA biosynthetic process
DGM85_08135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DGM85_08140	COG0443	Heat shock 70 kDa protein
DGM85_08145	COG0484	heat shock protein binding
DGM85_08150	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DGM85_08180	COG0583	DNA-binding transcription factor activity
DGM85_08190	COG1132	(ABC) transporter
DGM85_08225	COG2850	peptidyl-arginine hydroxylation
DGM85_08280	COG1131	(ABC) transporter
DGM85_08285	COG1725	Transcriptional regulator
DGM85_08295	COG0386	Belongs to the glutathione peroxidase family
DGM85_08315	COG2900	Belongs to the SlyX family
DGM85_08345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGM85_08355	COG0646	methionine synthase
DGM85_08355	COG1410	methionine synthase
DGM85_08360	COG1410	methionine synthase
DGM85_08360	COG0646	methionine synthase
DGM85_08365	COG2226	methyltransferase
DGM85_08370	COG1960	acyl-CoA dehydrogenase activity
DGM85_08375	COG1960	acyl-CoA dehydrogenase activity
DGM85_08390	COG0557	exoribonuclease II activity
DGM85_08400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGM85_08415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGM85_08425	COG0704	Plays a role in the regulation of phosphate uptake
DGM85_08430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DGM85_08435	COG0581	inorganic phosphate transmembrane transporter activity
DGM85_08440	COG0573	inorganic phosphate transmembrane transporter activity
DGM85_08445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DGM85_08470	COG0659	secondary active sulfate transmembrane transporter activity
DGM85_08475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DGM85_08485	COG1024	Enoyl-CoA hydratase
DGM85_08495	COG0494	nUDIX hydrolase
DGM85_08530	COG0488	(ABC) transporter
DGM85_08540	COG0116	Belongs to the methyltransferase superfamily
DGM85_08540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGM85_08545	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DGM85_08565	COG2925	Exonuclease
DGM85_08575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGM85_08580	COG3844	kynureninase activity
DGM85_08590	COG0662	Cupin 2, conserved barrel domain protein
DGM85_08595	COG0288	reversible hydration of carbon dioxide
DGM85_08675	COG0017	Asparaginyl-tRNA synthetase
DGM85_08685	COG0316	Belongs to the HesB IscA family
DGM85_08690	COG0360	Binds together with S18 to 16S ribosomal RNA
DGM85_08695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DGM85_08700	COG0359	binds to the 23S rRNA
DGM85_08710	COG3115	cell septum assembly
DGM85_08720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGM85_08725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DGM85_08730	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DGM85_08745	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DGM85_08755	COG4993	Dehydrogenase
DGM85_08765	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DGM85_08780	COG2986	histidine ammonia-lyase
DGM85_08785	COG1228	amidohydrolase
DGM85_08825	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DGM85_08830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DGM85_08835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DGM85_08840	COG1605	Chorismate mutase
DGM85_08840	COG0077	Prephenate dehydratase
DGM85_08845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DGM85_08860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DGM85_08865	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DGM85_08870	COG0583	DNA-binding transcription factor activity
DGM85_08900	COG0840	transmembrane signaling receptor activity
DGM85_08920	COG0784	Response regulator, receiver
DGM85_08920	COG4191	Histidine kinase
DGM85_08930	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DGM85_08950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGM85_08960	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGM85_08970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DGM85_08985	COG1595	DNA-templated transcription, initiation
DGM85_09040	COG2244	polysaccharide biosynthetic process
DGM85_09070	COG2264	protein methyltransferase activity
DGM85_09080	COG0438	transferase activity, transferring glycosyl groups
DGM85_09095	COG1136	(ABC) transporter
DGM85_09110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGM85_09125	COG1253	flavin adenine dinucleotide binding
DGM85_09140	COG0306	phosphate transporter
DGM85_09165	COG0504	CTP synthase activity
DGM85_09170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DGM85_09180	COG0148	phosphopyruvate hydratase activity
DGM85_09185	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DGM85_09195	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DGM85_09200	COG0585	pseudouridine synthase activity
DGM85_09205	COG2840	Smr protein MutS2
DGM85_09210	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DGM85_09215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGM85_09220	COG1238	metal cluster binding
DGM85_09230	COG3737	Protein of unknown function (DUF498/DUF598)
DGM85_09235	COG1534	Rna-binding protein
DGM85_09240	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DGM85_09250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DGM85_09255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DGM85_09265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DGM85_09270	COG1546	Belongs to the CinA family
DGM85_09280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGM85_09285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DGM85_09295	COG2137	regulation of response to DNA damage stimulus
DGM85_09300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DGM85_09305	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DGM85_09320	COG1741	Belongs to the pirin family
DGM85_09325	COG0583	DNA-binding transcription factor activity
DGM85_09350	COG0351	phosphomethylpyrimidine kinase
DGM85_09365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DGM85_09370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DGM85_09385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGM85_09395	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DGM85_09400	COG3734	2-keto-3-deoxy-galactonokinase
DGM85_09410	COG4948	Mandelate Racemase Muconate Lactonizing
DGM85_09415	COG0800	Aldolase
DGM85_09455	COG1501	Belongs to the glycosyl hydrolase 31 family
DGM85_09465	COG1070	Carbohydrate kinase
DGM85_09470	COG2115	Belongs to the xylose isomerase family
DGM85_09475	COG0477	Major facilitator Superfamily
DGM85_09490	COG3328	transposase activity
DGM85_09495	COG1469	GTP cyclohydrolase I activity
DGM85_09520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DGM85_09525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DGM85_09530	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DGM85_09535	COG0166	Belongs to the GPI family
DGM85_09555	COG1472	Belongs to the glycosyl hydrolase 3 family
DGM85_09570	COG2203	Gaf domain
DGM85_09570	COG5001	Diguanylate cyclase
DGM85_09570	COG3706	GGDEF domain
DGM85_09570	COG4251	negative regulation of phosphorylation
DGM85_09575	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGM85_09580	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DGM85_09595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DGM85_09600	COG0671	phosphoesterase, PA-phosphatase related
DGM85_09610	COG1794	racemase activity, acting on amino acids and derivatives
DGM85_09620	COG0697	spore germination
DGM85_09625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DGM85_09630	COG0167	dihydroorotate dehydrogenase activity
DGM85_09650	COG1012	belongs to the aldehyde dehydrogenase family
DGM85_09695	COG1082	Xylose isomerase domain protein TIM barrel
DGM85_09705	COG2211	Major facilitator Superfamily
DGM85_09720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DGM85_09725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DGM85_09740	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DGM85_09745	COG0072	phenylalanine-tRNA ligase activity
DGM85_09745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGM85_09795	COG0438	transferase activity, transferring glycosyl groups
DGM85_09800	COG0438	transferase activity, transferring glycosyl groups
DGM85_09810	COG0438	transferase activity, transferring glycosyl groups
DGM85_09835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGM85_09845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGM85_09865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DGM85_09875	COG1960	acyl-CoA dehydrogenase activity
DGM85_09885	COG3040	lipid binding
DGM85_09900	COG0322	excinuclease ABC activity
DGM85_09915	COG4191	Histidine kinase
DGM85_09915	COG0784	Response regulator, receiver
DGM85_09935	COG1194	a g-specific adenine glycosylase
DGM85_09945	COG0552	protein localization to endoplasmic reticulum
DGM85_09955	COG3938	Belongs to the proline racemase family
DGM85_09960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM85_09975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGM85_09985	COG0006	proline dipeptidase activity
DGM85_10005	COG0531	amino acid
DGM85_10130	COG3328	transposase activity
DGM85_10140	COG0460	homoserine dehydrogenase
DGM85_10140	COG0527	aspartate kinase activity
DGM85_10175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGM85_10180	COG0124	histidyl-tRNA synthetase
DGM85_10190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DGM85_10195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DGM85_10200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGM85_10205	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DGM85_10205	COG0131	Imidazoleglycerol-phosphate dehydratase
DGM85_10210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DGM85_10215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DGM85_10220	COG0107	imidazoleglycerol-phosphate synthase activity
DGM85_10225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DGM85_10225	COG0140	phosphoribosyl-ATP diphosphatase activity
DGM85_10240	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DGM85_10245	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DGM85_10250	COG0235	Class ii aldolase
DGM85_10255	COG0531	amino acid
DGM85_10260	COG0531	amino acid
DGM85_10270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DGM85_10275	COG0277	FAD linked oxidase domain protein
DGM85_10295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGM85_10340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DGM85_10345	COG2258	MOSC domain
DGM85_10350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DGM85_10355	COG0505	Belongs to the CarA family
DGM85_10365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DGM85_10370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGM85_10380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DGM85_10400	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DGM85_10410	COG2198	Histidine kinase
DGM85_10410	COG2205	protein histidine kinase activity
DGM85_10410	COG0784	Response regulator, receiver
DGM85_10415	COG2198	Histidine kinase
DGM85_10415	COG0784	Response regulator, receiver
DGM85_10415	COG2205	protein histidine kinase activity
DGM85_10420	COG1024	Enoyl-CoA hydratase
DGM85_10425	COG0318	PFAM AMP-dependent synthetase and ligase
DGM85_10460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGM85_10470	COG2201	protein-glutamate methylesterase activity
DGM85_10475	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DGM85_10485	COG0840	transmembrane signaling receptor activity
DGM85_10495	COG0835	chemotaxis
DGM85_10510	COG0840	transmembrane signaling receptor activity
DGM85_10515	COG0840	transmembrane signaling receptor activity
DGM85_10520	COG0840	transmembrane signaling receptor activity
DGM85_10525	COG0840	transmembrane signaling receptor activity
DGM85_10530	COG0840	transmembrane signaling receptor activity
DGM85_10545	COG0840	transmembrane signaling receptor activity
DGM85_10550	COG0840	transmembrane signaling receptor activity
DGM85_10555	COG0840	transmembrane signaling receptor activity
DGM85_10560	COG0840	transmembrane signaling receptor activity
DGM85_10575	COG0840	transmembrane signaling receptor activity
DGM85_10590	COG0840	transmembrane signaling receptor activity
DGM85_10605	COG0745	RESPONSE REGULATOR receiver
DGM85_10615	COG0835	chemotaxis
DGM85_10620	COG1192	Involved in chromosome partitioning
DGM85_10625	COG1360	Flagellar Motor Protein
DGM85_10630	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DGM85_10670	COG0643	Histidine kinase
DGM85_10670	COG0784	Response regulator, receiver
DGM85_10670	COG2198	Histidine kinase
DGM85_10700	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DGM85_10725	COG3039	Transposase
DGM85_10735	COG1684	flagellar biosynthetic protein fliR
DGM85_10755	COG3190	flagellar
DGM85_10805	COG1677	Flagellar hook-basal body complex protein FliE
DGM85_10825	COG3328	transposase activity
DGM85_10840	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DGM85_10850	COG3328	transposase activity
DGM85_10880	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_10885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGM85_10905	COG2201	protein-glutamate methylesterase activity
DGM85_10935	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DGM85_10945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DGM85_10955	COG1705	Flagellar rod assembly protein muramidase FlgJ
DGM85_10955	COG3951	Flagellar rod assembly protein muramidase FlgJ
DGM85_10960	COG1706	bacterial-type flagellum-dependent cell motility
DGM85_10965	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DGM85_10975	COG4787	bacterial-type flagellum-dependent cell motility
DGM85_10985	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DGM85_10990	COG1558	bacterial-type flagellum-dependent cell motility
DGM85_11000	COG0784	Response regulator, receiver
DGM85_11000	COG0835	chemotaxis
DGM85_11020	COG5002	protein histidine kinase activity
DGM85_11030	COG4585	Histidine kinase
DGM85_11050	COG2915	High frequency lysogenization protein hflD homolog
DGM85_11055	COG0482	sulfurtransferase activity
DGM85_11070	COG0542	response to heat
DGM85_11080	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DGM85_11090	COG0492	ferredoxin-NADP+ reductase activity
DGM85_11095	COG1674	ftsk spoiiie
DGM85_11105	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DGM85_11120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DGM85_11125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DGM85_11130	COG0183	Belongs to the thiolase family
DGM85_11135	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGM85_11135	COG1024	Enoyl-CoA hydratase
DGM85_11170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGM85_11175	COG1160	GTP binding
DGM85_11180	COG0303	'Molybdopterin
DGM85_11185	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DGM85_11225	COG3328	transposase activity
DGM85_11240	COG0708	Exodeoxyribonuclease III
DGM85_11250	COG0303	'Molybdopterin
DGM85_11255	COG0746	molybdenum cofactor guanylyltransferase activity
DGM85_11280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGM85_11280	COG1648	precorrin-2 dehydrogenase activity
DGM85_11290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DGM85_11300	COG2223	nitrite transmembrane transporter activity
DGM85_11305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DGM85_11315	COG0243	molybdopterin cofactor binding
DGM85_11330	COG3685	Protein conserved in bacteria
DGM85_11350	COG5001	Diguanylate cyclase
DGM85_11360	COG4566	intracellular signal transduction
DGM85_11420	COG1238	metal cluster binding
DGM85_11440	COG3328	transposase activity
DGM85_11500	COG0800	Aldolase
DGM85_11505	COG0129	dihydroxy-acid dehydratase activity
DGM85_11510	COG0363	glucosamine-6-phosphate deaminase activity
DGM85_11515	COG0837	glucose binding
DGM85_11520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGM85_11530	COG0354	folic acid binding
DGM85_11545	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DGM85_11560	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DGM85_11565	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DGM85_11575	COG4591	ABC-type transport system involved in lipoprotein release permease component
DGM85_11580	COG1136	(ABC) transporter
DGM85_11595	COG0811	peptide transport
DGM85_11605	COG1132	(ABC) transporter
DGM85_11610	COG1663	tetraacyldisaccharide 4'-kinase activity
DGM85_11615	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DGM85_11620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DGM85_11630	COG0322	excinuclease ABC activity
DGM85_11635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGM85_11660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DGM85_11680	COG1054	Belongs to the UPF0176 family
DGM85_11690	COG3328	transposase activity
DGM85_11695	COG3039	Transposase
DGM85_11710	COG3064	Membrane
DGM85_11715	COG0428	transporter
DGM85_11725	COG2154	pterin-4-alpha-carbinolamine dehydratase
DGM85_11760	COG0640	Transcriptional regulator
DGM85_11870	COG3328	transposase activity
DGM85_11890	COG0784	Response regulator, receiver
DGM85_11890	COG2205	protein histidine kinase activity
DGM85_11895	COG2183	response to ionizing radiation
DGM85_11905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM85_11905	COG0723	plastoquinol--plastocyanin reductase activity
DGM85_11920	COG3243	poly(R)-hydroxyalkanoic acid synthase
DGM85_11930	COG1183	phosphatidylcholine synthase activity
DGM85_11935	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_11950	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DGM85_11965	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DGM85_11980	COG1914	H( )-stimulated, divalent metal cation uptake system
DGM85_12000	COG2814	Major facilitator Superfamily
DGM85_12015	COG1335	isochorismatase
DGM85_12035	COG2197	response regulator
DGM85_12065	COG0583	DNA-binding transcription factor activity
DGM85_12070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGM85_12075	COG3002	Belongs to the UPF0753 family
DGM85_12085	COG0604	alcohol dehydrogenase
DGM85_12090	COG3384	dioxygenase
DGM85_12120	COG3328	transposase activity
DGM85_12155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGM85_12155	COG0519	Catalyzes the synthesis of GMP from XMP
DGM85_12165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DGM85_12180	COG0475	glutathione-regulated potassium exporter activity
DGM85_12180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGM85_12185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DGM85_12195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGM85_12200	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DGM85_12210	COG0776	regulation of translation
DGM85_12215	COG0539	negative regulation of cytoplasmic translation
DGM85_12220	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DGM85_12235	COG2957	Belongs to the agmatine deiminase family
DGM85_12240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGM85_12265	COG0395	ABC-type sugar transport system, permease component
DGM85_12270	COG1175	transmembrane transport
DGM85_12305	COG2350	Protein conserved in bacteria
DGM85_12310	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DGM85_12315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DGM85_12320	COG1187	pseudouridine synthase activity
DGM85_12335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGM85_12340	COG0436	Aminotransferase
DGM85_12345	COG4133	protoheme IX ABC transporter activity
DGM85_12365	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGM85_12395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGM85_12405	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DGM85_12410	COG4988	ABC transporter
DGM85_12420	COG1294	oxidase, subunit
DGM85_12450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DGM85_12455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DGM85_12465	COG0165	Argininosuccinate lyase
DGM85_12470	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DGM85_12480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DGM85_12485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGM85_12495	COG0137	argininosuccinate synthase activity
DGM85_12500	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DGM85_12510	COG0215	cysteine-tRNA ligase activity
DGM85_12515	COG2166	iron-sulfur cluster assembly
DGM85_12530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DGM85_12535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DGM85_12550	COG3328	transposase activity
DGM85_12570	COG4302	ethanolamine ammonia-lyase activity
DGM85_12600	COG3039	Transposase
DGM85_12635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DGM85_12640	COG0402	S-adenosylhomocysteine deaminase activity
DGM85_12650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGM85_12655	COG1509	lysine 2,3-aminomutase activity
DGM85_12660	COG3300	MHYT domain
DGM85_12660	COG5001	Diguanylate cyclase
DGM85_12675	COG0483	inositol monophosphate 1-phosphatase activity
DGM85_12680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DGM85_12695	COG0488	(ABC) transporter
DGM85_12700	COG0513	Belongs to the DEAD box helicase family
DGM85_12705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DGM85_12710	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DGM85_12735	COG3328	transposase activity
DGM85_12750	COG0625	glutathione transferase activity
DGM85_12765	COG4681	YaeQ
DGM85_12770	COG2081	HI0933 family
DGM85_12780	COG0501	Belongs to the peptidase M48B family
DGM85_12785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGM85_12790	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_12815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DGM85_12820	COG0860	N-Acetylmuramoyl-L-alanine amidase
DGM85_12825	COG0802	atpase or kinase
DGM85_12830	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DGM85_12830	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGM85_12835	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGM85_12840	COG1570	exodeoxyribonuclease VII activity
DGM85_12855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGM85_12900	COG0835	chemotaxis
DGM85_12905	COG0840	transmembrane signaling receptor activity
DGM85_12935	COG2969	positive regulation of protein catabolic process
DGM85_12940	COG0625	glutathione transferase activity
DGM85_12945	COG2857	Cytochrome c1
DGM85_12950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DGM85_12955	COG0723	plastoquinol--plastocyanin reductase activity
DGM85_12965	COG0741	lytic transglycosylase activity
DGM85_12980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGM85_12985	COG1702	phosphate starvation-inducible protein PhoH
DGM85_12995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DGM85_13005	COG4535	Mg2 and Co2 transporter CorC
DGM85_13020	COG1012	belongs to the aldehyde dehydrogenase family
DGM85_13025	COG1177	transmembrane transport
DGM85_13030	COG1176	ABC-type spermidine putrescine transport system, permease component I
DGM85_13035	COG3842	ATPase activity
DGM85_13055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DGM85_13070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DGM85_13075	COG0174	glutamine synthetase
DGM85_13080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM85_13090	COG2703	oxygen carrier activity
DGM85_13095	COG0477	Major facilitator Superfamily
DGM85_13105	COG0243	molybdopterin cofactor binding
DGM85_13110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DGM85_13115	COG2223	nitrite transmembrane transporter activity
DGM85_13130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DGM85_13140	COG2733	membrane
DGM85_13145	COG0784	Response regulator, receiver
DGM85_13145	COG2205	protein histidine kinase activity
DGM85_13145	COG5002	protein histidine kinase activity
DGM85_13155	COG0477	Major facilitator Superfamily
DGM85_13160	COG0840	transmembrane signaling receptor activity
DGM85_13195	COG2902	Dehydrogenase
DGM85_13205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM85_13210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM85_13215	COG1609	Transcriptional regulator
DGM85_13220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGM85_13220	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGM85_13225	COG1105	Belongs to the carbohydrate kinase PfkB family
DGM85_13230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGM85_13230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGM85_13250	COG3328	transposase activity
DGM85_13270	COG3328	transposase activity
DGM85_13280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DGM85_13290	COG1862	Preprotein translocase
DGM85_13295	COG0343	queuine tRNA-ribosyltransferase activity
DGM85_13300	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DGM85_13340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DGM85_13345	COG3291	Pkd domain containing protein
DGM85_13350	COG0405	Gamma-glutamyltransferase
DGM85_13355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DGM85_13370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DGM85_13375	COG0742	ribosomal rna small subunit methyltransferase
DGM85_13380	COG0326	Molecular chaperone. Has ATPase activity
DGM85_13450	COG3702	type iv secretory pathway
DGM85_13470	COG2948	multi-organism process
DGM85_13490	COG3505	Type IV secretory pathway VirD4
DGM85_13505	COG0556	nucleotide-excision repair
DGM85_13610	COG4695	Portal protein
DGM85_13655	COG3179	chitinase
DGM85_13795	COG3275	phosphorelay sensor kinase activity
DGM85_13800	COG1611	Belongs to the LOG family
DGM85_13815	COG2095	MarC family integral membrane protein
DGM85_13825	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGM85_13860	COG1185	polyribonucleotide nucleotidyltransferase activity
DGM85_13865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DGM85_13870	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DGM85_13875	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DGM85_13880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DGM85_13885	COG0195	Participates in both transcription termination and antitermination
DGM85_13890	COG0779	Required for maturation of 30S ribosomal subunits
DGM85_13900	COG1007	ATP synthesis coupled electron transport
DGM85_13925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGM85_13930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DGM85_13940	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DGM85_13945	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DGM85_13950	COG0649	NAD binding
DGM85_13955	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGM85_13960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGM85_13965	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGM85_13980	COG0149	triose-phosphate isomerase activity
DGM85_13985	COG4221	oxidoreductase activity
DGM85_14015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGM85_14020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DGM85_14025	COG0159	tryptophan synthase activity
DGM85_14035	COG0133	tryptophan synthase activity
DGM85_14045	COG0135	phosphoribosylanthranilate isomerase activity
DGM85_14050	COG0101	tRNA pseudouridine synthase activity
DGM85_14065	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DGM85_14070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DGM85_14075	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DGM85_14080	COG2890	protein-(glutamine-N5) methyltransferase activity
DGM85_14090	COG0688	phosphatidylethanolamine metabolic process
DGM85_14100	COG0433	COG0433 Predicted ATPase
DGM85_14125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGM85_14130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGM85_14155	COG0717	Belongs to the dCTP deaminase family
DGM85_14165	COG0489	protein tyrosine kinase activity
DGM85_14205	COG3590	peptidase
DGM85_14230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGM85_14235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGM85_14240	COG2311	Membrane
DGM85_14245	COG1047	Peptidyl-prolyl cis-trans
DGM85_14250	COG0791	NLP P60 protein
DGM85_14255	COG0791	NLP P60 protein
DGM85_14265	COG4106	trans-aconitate 2-methyltransferase activity
DGM85_14270	COG1301	dicarboxylic acid transport
DGM85_14275	COG1785	Belongs to the alkaline phosphatase family
DGM85_14285	COG0037	tRNA processing
DGM85_14290	COG1722	exodeoxyribonuclease VII activity
DGM85_14295	COG0142	geranyltranstransferase activity
DGM85_14300	COG4104	PAAR repeat-containing protein
DGM85_14310	COG0312	modulator of DNA gyrase
DGM85_14315	COG3028	Belongs to the UPF0307 family
DGM85_14320	COG0312	modulator of DNA gyrase
DGM85_14330	COG3164	Protein of unknown function
DGM85_14340	COG0424	maF-like protein
DGM85_14345	COG2968	Membrane
DGM85_14360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DGM85_14375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DGM85_14395	COG0495	leucyl-tRNA aminoacylation
DGM85_14405	COG3118	belongs to the thioredoxin family
DGM85_14430	COG2155	Conserved Protein
DGM85_14485	COG1132	(ABC) transporter
DGM85_14515	COG0745	RESPONSE REGULATOR receiver
DGM85_14520	COG5000	phosphorelay sensor kinase activity
DGM85_14520	COG5002	protein histidine kinase activity
DGM85_14525	COG0475	glutathione-regulated potassium exporter activity
DGM85_14535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGM85_14555	COG1187	pseudouridine synthase activity
DGM85_14560	COG5001	Diguanylate cyclase
DGM85_14560	COG5002	protein histidine kinase activity
DGM85_14570	COG1595	DNA-templated transcription, initiation
DGM85_14690	COG0667	Aldo Keto reductase
DGM85_14695	COG2814	Major facilitator Superfamily
DGM85_14700	COG0583	DNA-binding transcription factor activity
DGM85_14710	COG2207	Transcriptional regulator
DGM85_14720	COG1309	transcriptional regulator
DGM85_14730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM85_14745	COG0735	belongs to the Fur family
DGM85_14750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGM85_14775	COG4452	Inner membrane protein CreD
DGM85_14790	COG2205	protein histidine kinase activity
DGM85_14795	COG0745	RESPONSE REGULATOR receiver
DGM85_14800	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DGM85_14810	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DGM85_14820	COG0643	Histidine kinase
DGM85_14820	COG2198	Histidine kinase
DGM85_14825	COG0840	transmembrane signaling receptor activity
DGM85_14830	COG0835	chemotaxis
DGM85_14835	COG2199	diguanylate cyclase activity
DGM85_14835	COG2200	EAL domain
DGM85_14835	COG2202	Pas domain
DGM85_14840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGM85_14845	COG2201	protein-glutamate methylesterase activity
DGM85_14855	COG3590	peptidase
DGM85_14870	COG1515	deoxyribonuclease V activity
DGM85_14880	COG1741	Belongs to the pirin family
DGM85_14895	COG1741	Belongs to the pirin family
DGM85_14900	COG1966	Carbon starvation protein
DGM85_14905	COG2879	small protein
DGM85_14960	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DGM85_14965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGM85_14970	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGM85_14975	COG2080	2 iron, 2 sulfur cluster binding
DGM85_14980	COG0604	alcohol dehydrogenase
DGM85_14980	COG3321	synthase
DGM85_14980	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_14985	COG4251	negative regulation of phosphorylation
DGM85_14985	COG2203	Gaf domain
DGM85_14985	COG3706	GGDEF domain
DGM85_14985	COG5001	Diguanylate cyclase
DGM85_14990	COG0629	single-stranded DNA binding
DGM85_14995	COG0142	geranyltranstransferase activity
DGM85_15005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DGM85_15020	COG0527	aspartate kinase activity
DGM85_15025	COG0384	phenazine biosynthesis protein PhzF
DGM85_15030	COG0384	phenazine biosynthesis protein PhzF
DGM85_15040	COG1764	response to oxidative stress
DGM85_15045	COG0540	Belongs to the ATCase OTCase family
DGM85_15050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DGM85_15055	COG1678	Uncharacterized ACR, COG1678
DGM85_15060	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DGM85_15065	COG0519	Catalyzes the synthesis of GMP from XMP
DGM85_15090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DGM85_15105	COG0739	heme binding
DGM85_15125	COG0693	protein deglycase activity
DGM85_15135	COG1959	2 iron, 2 sulfur cluster binding
DGM85_15140	COG0719	Fe-S assembly protein
DGM85_15145	COG0396	ATPase activity
DGM85_15150	COG0719	Fe-S assembly protein
DGM85_15155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DGM85_15165	COG0456	acetyltransferase
DGM85_15170	COG2146	nitrite reductase [NAD(P)H] activity
DGM85_15175	COG4774	siderophore transport
DGM85_15180	COG3128	pkhd-type hydroxylase
DGM85_15205	COG1477	protein flavinylation
DGM85_15210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGM85_15220	COG3328	transposase activity
DGM85_15225	COG1555	photosystem II stabilization
DGM85_15230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGM85_15245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DGM85_15255	COG0628	permease
DGM85_15265	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DGM85_15280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DGM85_15300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DGM85_15305	COG0271	Belongs to the BolA IbaG family
DGM85_15315	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DGM85_15325	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DGM85_15330	COG1137	ATPase activity
DGM85_15345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGM85_15350	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DGM85_15355	COG1660	Displays ATPase and GTPase activities
DGM85_15370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGM85_15375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGM85_15385	COG2239	Acts as a magnesium transporter
DGM85_15395	COG1294	oxidase, subunit
DGM85_15450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGM85_15450	COG0551	DNA topoisomerase type I activity
DGM85_15470	COG2951	lytic endotransglycosylase activity
DGM85_15550	COG1271	oxidase subunit
DGM85_15560	COG1113	amino acid transport
DGM85_15580	COG3328	transposase activity
DGM85_15615	COG2197	response regulator
DGM85_15620	COG0531	amino acid
DGM85_15680	COG2814	Major facilitator Superfamily
DGM85_15690	COG0754	glutathionylspermidine amidase activity
DGM85_15715	COG1842	Phage shock protein A
DGM85_15725	COG0259	pyridoxamine-phosphate oxidase activity
DGM85_15730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DGM85_15735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DGM85_15745	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DGM85_15750	COG2814	Major facilitator Superfamily
DGM85_15780	COG2353	YceI-like domain
DGM85_15800	COG1760	l-serine dehydratase
DGM85_15810	COG0460	homoserine dehydrogenase
DGM85_15810	COG0527	aspartate kinase activity
DGM85_15815	COG0626	cystathionine gamma-synthase activity
DGM85_15820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGM85_15825	COG0739	heme binding
DGM85_15830	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DGM85_15835	COG1272	protein, Hemolysin III
DGM85_15840	COG2982	Protein involved in outer membrane biogenesis
DGM85_15845	COG0516	GMP reductase activity
DGM85_15845	COG0517	IMP dehydrogenase activity
DGM85_15850	COG0463	Glycosyl transferase, family 2
DGM85_15855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGM85_15860	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DGM85_15870	COG4771	TonB-dependent receptor
DGM85_15875	COG1309	transcriptional regulator
DGM85_15885	COG1960	acyl-CoA dehydrogenase activity
DGM85_15920	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DGM85_15930	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DGM85_15955	COG0534	Mate efflux family protein
DGM85_15960	COG0335	large ribosomal subunit rRNA binding
DGM85_15965	COG0336	Belongs to the RNA methyltransferase TrmD family
DGM85_15970	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DGM85_15975	COG0228	four-way junction DNA binding
DGM85_15980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DGM85_15990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DGM85_16015	COG0784	Response regulator, receiver
DGM85_16015	COG4191	Histidine kinase
DGM85_16020	COG4999	Histidine kinase
DGM85_16020	COG3437	response regulator, receiver
DGM85_16020	COG2205	protein histidine kinase activity
DGM85_16020	COG3850	Histidine kinase
DGM85_16025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGM85_16035	COG2205	protein histidine kinase activity
DGM85_16040	COG5507	3-demethylubiquinone-9 3-methyltransferase
DGM85_16050	COG4771	TonB-dependent receptor
DGM85_16075	COG2172	sigma factor antagonist activity
DGM85_16080	COG1366	Belongs to the anti-sigma-factor antagonist family
DGM85_16085	COG1366	Belongs to the anti-sigma-factor antagonist family
DGM85_16120	COG2207	Transcriptional regulator
DGM85_16130	COG3152	Membrane
DGM85_16145	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DGM85_16150	COG1845	cytochrome c oxidase, subunit III
DGM85_16155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DGM85_16170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DGM85_16175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DGM85_16180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DGM85_16185	COG0196	riboflavin kinase activity
DGM85_16195	COG0268	Binds directly to 16S ribosomal RNA
DGM85_16200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DGM85_16205	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DGM85_16210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DGM85_16215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DGM85_16220	COG0824	Thioesterase
DGM85_16235	COG1946	Acyl-CoA thioesterase
DGM85_16245	COG1595	DNA-templated transcription, initiation
DGM85_16260	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DGM85_16270	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DGM85_16300	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DGM85_16315	COG2197	response regulator
DGM85_16320	COG4585	Histidine kinase
DGM85_16335	COG0850	regulation of cytokinetic process
DGM85_16340	COG2894	cell division
DGM85_16345	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DGM85_16355	COG0642	Histidine kinase
DGM85_16360	COG0745	RESPONSE REGULATOR receiver
DGM85_16375	COG2194	sulfuric ester hydrolase activity
DGM85_16385	COG2963	transposase activity
DGM85_16410	COG2814	Major facilitator Superfamily
DGM85_16435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGM85_16435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGM85_16445	COG0656	L-ascorbic acid biosynthetic process
DGM85_16450	COG0753	catalase activity
DGM85_16480	COG1917	Cupin 2, conserved barrel domain protein
DGM85_16480	COG2207	Transcriptional regulator
DGM85_16515	COG0823	Involved in the tonB-independent uptake of proteins
DGM85_16515	COG1506	peptidase
DGM85_16550	COG1297	OPT oligopeptide transporter protein
DGM85_16570	COG0587	DNA-directed DNA polymerase activity
DGM85_16585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGM85_16620	COG2080	2 iron, 2 sulfur cluster binding
DGM85_16625	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGM85_16630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGM85_16660	COG0492	ferredoxin-NADP+ reductase activity
DGM85_16685	COG3537	Alpha-1,2-mannosidase
DGM85_16695	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_16700	COG3387	PFAM Glycoside hydrolase 15-related
DGM85_16780	COG1309	transcriptional regulator
DGM85_16785	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_16795	COG0308	aminopeptidase N
DGM85_16800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DGM85_16810	COG0330	HflC and HflK could
DGM85_16815	COG0330	HflC and HflK could
DGM85_16835	COG0678	peroxiredoxin activity
DGM85_16845	COG4953	penicillin-binding protein 1C
DGM85_16850	COG3852	Histidine kinase
DGM85_16875	COG2373	Large extracellular alpha-helical protein
DGM85_16910	COG3328	transposase activity
DGM85_16930	COG3829	transcription factor binding
DGM85_16965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DGM85_16970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DGM85_16985	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_17000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGM85_17005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DGM85_17010	COG1399	metal-binding, possibly nucleic acid-binding protein
DGM85_17015	COG0424	maF-like protein
DGM85_17030	COG0714	Associated with various cellular activities
DGM85_17050	COG0537	adenosine 5'-monophosphoramidase activity
DGM85_17055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DGM85_17060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DGM85_17080	COG0314	molybdopterin synthase activity
DGM85_17085	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DGM85_17090	COG0315	cyclic pyranopterin monophosphate synthase activity
DGM85_17100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DGM85_17105	COG1234	tRNA 3'-trailer cleavage
DGM85_17110	COG3642	lipopolysaccharide core region biosynthetic process
DGM85_17115	COG0859	PFAM glycosyl transferase family 9
DGM85_17140	COG0631	protein serine/threonine phosphatase activity
DGM85_17145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGM85_17150	COG0328	RNA-DNA hybrid ribonuclease activity
DGM85_17160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGM85_17170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGM85_17200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DGM85_17210	COG0544	peptidyl-prolyl cis-trans isomerase activity
DGM85_17225	COG3328	transposase activity
DGM85_17265	COG0473	3-isopropylmalate dehydrogenase activity
DGM85_17280	COG4783	chaperone-mediated protein folding
DGM85_17295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DGM85_17305	COG0438	transferase activity, transferring glycosyl groups
DGM85_17310	COG0671	phosphoesterase, PA-phosphatase related
DGM85_17315	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGM85_17325	COG3291	Pkd domain containing protein
DGM85_17335	COG2833	Protein of unknown function (DUF455)
DGM85_17355	COG0285	dihydrofolate synthase activity
DGM85_17365	COG0406	alpha-ribazole phosphatase activity
DGM85_17395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DGM85_17400	COG4208	sulfate ABC transporter
DGM85_17405	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DGM85_17410	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DGM85_17415	COG0156	8-amino-7-oxononanoate synthase activity
DGM85_17435	COG2885	chlorophyll binding
DGM85_17445	COG3328	transposase activity
DGM85_17460	COG0604	alcohol dehydrogenase
DGM85_17465	COG0446	pyridine nucleotide-disulphide oxidoreductase
DGM85_17465	COG1902	pentaerythritol trinitrate reductase activity
DGM85_17485	COG0625	glutathione transferase activity
DGM85_17490	COG0039	L-malate dehydrogenase activity
DGM85_17495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DGM85_17500	COG1217	gtp-binding protein TYPA
DGM85_17510	COG0154	amidase activity
DGM85_17520	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DGM85_17540	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DGM85_17545	COG0203	ribosomal protein L17
DGM85_17570	COG0201	protein transport
DGM85_17575	COG0200	Binds to the 23S rRNA
DGM85_17580	COG1841	ribosomal large subunit assembly
DGM85_17590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DGM85_17595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DGM85_17600	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DGM85_17610	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DGM85_17615	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DGM85_17625	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DGM85_17630	COG0255	Belongs to the universal ribosomal protein uL29 family
DGM85_17635	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DGM85_17640	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DGM85_17650	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DGM85_17655	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DGM85_17660	COG0089	rRNA binding
DGM85_17665	COG0088	Forms part of the polypeptide exit tunnel
DGM85_17670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DGM85_17675	COG0051	transcription antitermination factor activity, RNA binding
DGM85_17680	COG3328	transposase activity
DGM85_17695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGM85_17700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DGM85_17705	COG0049	tRNA binding
DGM85_17710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DGM85_17715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DGM85_17720	COG0085	RNA polymerase activity
DGM85_17730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DGM85_17735	COG0081	regulation of translation
DGM85_17740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DGM85_17745	COG0250	Participates in transcription elongation, termination and antitermination
DGM85_17760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGM85_17780	COG0012	GTP binding
DGM85_17785	COG0193	aminoacyl-tRNA hydrolase activity
DGM85_17790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DGM85_17795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DGM85_17805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DGM85_17810	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DGM85_17820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DGM85_17825	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DGM85_17835	COG0521	Mo-molybdopterin cofactor biosynthetic process
DGM85_17850	COG1254	Belongs to the acylphosphatase family
DGM85_17855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGM85_17860	COG1295	ribonuclease BN
DGM85_17885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DGM85_17890	COG1404	Belongs to the peptidase S8 family
DGM85_17895	COG1404	Belongs to the peptidase S8 family
DGM85_17900	COG1404	Belongs to the peptidase S8 family
DGM85_17905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DGM85_17920	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DGM85_17965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGM85_17965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGM85_17985	COG2890	protein-(glutamine-N5) methyltransferase activity
DGM85_17995	COG3634	alkyl hydroperoxide reductase activity
DGM85_18000	COG0583	DNA-binding transcription factor activity
DGM85_18010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGM85_18015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DGM85_18030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DGM85_18040	COG2197	response regulator
DGM85_18045	COG2205	protein histidine kinase activity
DGM85_18065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGM85_18075	COG0697	spore germination
DGM85_18095	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DGM85_18105	COG3386	PFAM SMP-30 Gluconolaconase
DGM85_18125	COG1024	Enoyl-CoA hydratase
DGM85_18135	COG0318	PFAM AMP-dependent synthetase and ligase
DGM85_18140	COG0583	DNA-binding transcription factor activity
DGM85_18145	COG3384	dioxygenase
DGM85_18175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGM85_18180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGM85_18195	COG2096	Adenosyltransferase
DGM85_18200	COG0123	including yeast histone deacetylase and acetoin utilization protein
DGM85_18215	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DGM85_18220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGM85_18225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DGM85_18230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DGM85_18235	COG2967	ApaG domain
DGM85_18240	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DGM85_18255	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DGM85_18260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DGM85_18270	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DGM85_18280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DGM85_18290	COG0642	Histidine kinase
DGM85_18305	COG4181	ATPase activity
DGM85_18315	COG2175	clavaminate synthase activity
DGM85_18325	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DGM85_18330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGM85_18350	COG4771	TonB-dependent receptor
DGM85_18360	COG0667	Aldo Keto reductase
DGM85_18365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DGM85_18370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGM85_18385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGM85_18390	COG4106	trans-aconitate 2-methyltransferase activity
DGM85_18400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DGM85_18440	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DGM85_18450	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DGM85_18455	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DGM85_18485	COG0366	Alpha amylase catalytic
DGM85_18505	COG0604	alcohol dehydrogenase
DGM85_18505	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_18505	COG3321	synthase
DGM85_18515	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DGM85_18525	COG0494	nUDIX hydrolase
DGM85_18530	COG0653	protein targeting
DGM85_18535	COG0739	heme binding
DGM85_18545	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DGM85_18560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DGM85_18565	COG1181	Belongs to the D-alanine--D-alanine ligase family
DGM85_18570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGM85_18575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DGM85_18585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGM85_18590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DGM85_18595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DGM85_18605	COG3116	cell division
DGM85_18650	COG0792	nuclease activity
DGM85_18655	COG1988	membrane-bound metal-dependent
DGM85_18660	COG0277	FAD linked oxidase domain protein
DGM85_18670	COG0745	RESPONSE REGULATOR receiver
DGM85_18675	COG2205	protein histidine kinase activity
DGM85_18685	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DGM85_18690	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DGM85_18710	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DGM85_18715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGM85_18720	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DGM85_18740	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGM85_18740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGM85_18750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DGM85_18755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DGM85_18765	COG0488	(ABC) transporter
DGM85_18770	COG0242	peptide deformylase activity
DGM85_18795	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DGM85_18800	COG1215	transferase activity, transferring glycosyl groups
DGM85_18805	COG1215	transferase activity, transferring glycosyl groups
DGM85_18885	COG2188	Transcriptional regulator
DGM85_18895	COG1450	Type ii and iii secretion system protein
DGM85_18910	COG3166	PFAM Fimbrial assembly family protein
DGM85_18915	COG3156	type II secretion system protein K
DGM85_18920	COG4795	General secretion pathway protein
DGM85_18925	COG2165	general secretion pathway protein
DGM85_18930	COG4970	Tfp pilus assembly protein FimT
DGM85_18935	COG2165	general secretion pathway protein
DGM85_18940	COG1459	type II secretion system
DGM85_18950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGM85_18955	COG1404	Belongs to the peptidase S8 family
DGM85_18965	COG1404	Belongs to the peptidase S8 family
DGM85_18970	COG5295	Hep Hag repeat protein
DGM85_18975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DGM85_18975	COG0047	phosphoribosylformylglycinamidine synthase activity
DGM85_18985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGM85_19000	COG4974	Belongs to the 'phage' integrase family
DGM85_19015	COG0795	lipopolysaccharide-transporting ATPase activity
DGM85_19025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGM85_19040	COG0525	valine-tRNA ligase activity
DGM85_19060	COG3039	Transposase
DGM85_19065	COG0617	tRNA 3'-terminal CCA addition
DGM85_19075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DGM85_19080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGM85_19085	COG1609	Transcriptional regulator
DGM85_19095	COG2188	Transcriptional regulator
DGM85_19140	COG1459	type II secretion system
DGM85_19195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DGM85_19200	COG4191	Histidine kinase
DGM85_19205	COG0784	Response regulator, receiver
DGM85_19210	COG4251	negative regulation of phosphorylation
DGM85_19215	COG2823	Periplasmic or secreted lipoprotein
DGM85_19220	COG0673	inositol 2-dehydrogenase activity
DGM85_19225	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DGM85_19260	COG1051	belongs to the nudix hydrolase family
DGM85_19260	COG1056	cytidyltransferase-related domain
DGM85_19285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DGM85_19290	COG0321	lipoyl(octanoyl) transferase activity
DGM85_19295	COG2921	Belongs to the UPF0250 family
DGM85_19305	COG1686	Belongs to the peptidase S11 family
DGM85_19310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DGM85_19315	COG2951	lytic endotransglycosylase activity
DGM85_19355	COG0772	Belongs to the SEDS family
DGM85_19370	COG1792	Involved in formation and maintenance of cell shape
DGM85_19375	COG1077	Cell shape determining protein MreB Mrl
DGM85_19380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGM85_19395	COG3284	Transcriptional regulator
DGM85_19445	COG0308	aminopeptidase N
DGM85_19450	COG5001	Diguanylate cyclase
DGM85_19450	COG3300	MHYT domain
DGM85_19455	COG2226	methyltransferase
DGM85_19485	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DGM85_19490	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DGM85_19495	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DGM85_19505	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DGM85_19515	COG2832	Protein of unknown function (DUF454)
DGM85_19525	COG0436	Aminotransferase
DGM85_19535	COG1505	serine-type exopeptidase activity
DGM85_19575	COG0181	hydroxymethylbilane synthase activity
DGM85_19585	COG3275	phosphorelay sensor kinase activity
DGM85_19595	COG2943	transferase activity, transferring hexosyl groups
DGM85_19645	COG0784	Response regulator, receiver
DGM85_19645	COG2205	protein histidine kinase activity
DGM85_19660	COG3447	MASE1 domain protein
DGM85_19660	COG5001	Diguanylate cyclase
DGM85_19660	COG5002	protein histidine kinase activity
DGM85_19705	COG0598	Magnesium transport protein CorA
DGM85_19715	COG1113	amino acid transport
DGM85_19725	COG5297	Belongs to the glycosyl hydrolase family 6
DGM85_19730	COG4305	rare lipoprotein A
DGM85_19735	COG0697	spore germination
DGM85_19760	COG1959	2 iron, 2 sulfur cluster binding
DGM85_19825	COG3328	transposase activity
DGM85_19845	COG3039	Transposase
DGM85_19895	COG1802	Transcriptional regulator
DGM85_19905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DGM85_19930	COG3052	prosthetic group binding
DGM85_19965	COG2353	YceI-like domain
DGM85_19970	COG0778	Nitroreductase
DGM85_19990	COG3039	Transposase
DGM85_20010	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGM85_20015	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DGM85_20025	COG3386	PFAM SMP-30 Gluconolaconase
DGM85_20060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DGM85_20065	COG3550	peptidyl-serine autophosphorylation
DGM85_20080	COG0459	protein refolding
DGM85_20100	COG1324	tolerance protein
DGM85_20110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DGM85_20115	COG0511	ligase activity, forming carbon-carbon bonds
DGM85_20125	COG0439	Biotin carboxylase
DGM85_20145	COG2264	protein methyltransferase activity
DGM85_20170	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DGM85_20175	COG4589	Belongs to the CDS family
DGM85_20200	COG2453	phosphatase
DGM85_20200	COG0671	phosphoesterase, PA-phosphatase related
DGM85_20205	COG2267	carboxylic ester hydrolase activity
DGM85_20210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGM85_20215	COG0138	bifunctional purine biosynthesis protein purh
DGM85_20225	COG0151	Belongs to the GarS family
DGM85_20235	COG1289	transmembrane transporter activity
DGM85_20240	COG2814	Major facilitator Superfamily
DGM85_20250	COG2814	Major facilitator Superfamily
DGM85_20265	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGM85_20280	COG0316	Belongs to the HesB IscA family
DGM85_20320	COG1051	belongs to the nudix hydrolase family
DGM85_20335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DGM85_20345	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DGM85_20355	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DGM85_20360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGM85_20370	COG0134	indole-3-glycerol-phosphate synthase activity
DGM85_20375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DGM85_20400	COG1597	lipid kinase activity
DGM85_20420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DGM85_20425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DGM85_20445	COG3179	chitinase
DGM85_20465	COG2111	Na H antiporter
DGM85_20465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGM85_20470	COG1006	Multisubunit Na H antiporter MnhC subunit
DGM85_20475	COG0651	ATP synthesis coupled electron transport
DGM85_20485	COG2212	antiporter activity
DGM85_20490	COG1320	monovalent cation:proton antiporter activity
DGM85_20510	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DGM85_20515	COG2852	Protein conserved in bacteria
DGM85_20535	COG3104	oligopeptide transport
DGM85_20545	COG3483	tryptophan 2,3-dioxygenase activity
DGM85_20560	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DGM85_20575	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGM85_20580	COG0513	Belongs to the DEAD box helicase family
DGM85_20595	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_20600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGM85_20635	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_20645	COG3039	Transposase
DGM85_20665	COG0702	epimerase
DGM85_20690	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGM85_20695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGM85_20700	COG0297	glycogen (starch) synthase activity
DGM85_20710	COG2354	Protein conserved in bacteria
DGM85_20715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGM85_20720	COG1368	sulfuric ester hydrolase activity
DGM85_20725	COG3264	Mechanosensitive ion channel
DGM85_20725	COG1511	domain protein
DGM85_20800	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DGM85_20870	COG3039	Transposase
DGM85_20900	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DGM85_20905	COG1040	competence protein
DGM85_20910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DGM85_20915	COG0156	8-amino-7-oxononanoate synthase activity
DGM85_20925	COG2267	carboxylic ester hydrolase activity
DGM85_20960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DGM85_20970	COG0445	tRNA wobble uridine modification
DGM85_20980	COG0657	acetylesterase activity
DGM85_20990	COG1414	Transcriptional regulator
DGM85_21000	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DGM85_21005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGM85_21015	COG3485	protocatechuate 3,4-dioxygenase
DGM85_21020	COG3485	protocatechuate 3,4-dioxygenase
DGM85_21035	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DGM85_21060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DGM85_21120	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DGM85_21135	COG0129	dihydroxy-acid dehydratase activity
DGM85_21165	COG1733	regulation of RNA biosynthetic process
DGM85_21170	COG0702	epimerase
DGM85_21210	COG0583	DNA-binding transcription factor activity
DGM85_21215	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGM85_21240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGM85_21245	COG2205	protein histidine kinase activity
DGM85_21250	COG0745	RESPONSE REGULATOR receiver
DGM85_21270	COG1902	pentaerythritol trinitrate reductase activity
DGM85_21275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DGM85_21290	COG2814	Major facilitator Superfamily
DGM85_21295	COG0583	DNA-binding transcription factor activity
DGM85_21310	COG0084	hydrolase, TatD family'
DGM85_21335	COG2252	PERMEase
DGM85_21375	COG0583	DNA-binding transcription factor activity
DGM85_21385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DGM85_21405	COG2072	flavoprotein involved in K transport
DGM85_21415	COG4807	Protein conserved in bacteria
DGM85_21430	COG1643	Atp-dependent helicase
DGM85_21440	COG1187	pseudouridine synthase activity
DGM85_21455	COG2130	NADP-dependent
DGM85_21475	COG1764	response to oxidative stress
DGM85_21480	COG1846	Transcriptional regulator
DGM85_21485	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DGM85_21495	COG0697	spore germination
DGM85_21560	COG1960	acyl-CoA dehydrogenase activity
DGM85_21565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DGM85_21570	COG4770	biotin carboxylase activity
DGM85_21600	COG3328	transposase activity
DGM85_21615	COG3039	Transposase
DGM85_21635	COG2224	Isocitrate lyase
DGM85_21640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DGM85_21645	COG0583	DNA-binding transcription factor activity
DGM85_21650	COG0475	glutathione-regulated potassium exporter activity
DGM85_21685	COG0339	signal peptide processing
DGM85_21690	COG1446	asparaginase
DGM85_21715	COG0564	pseudouridine synthase activity
DGM85_21725	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGM85_21740	COG1181	Belongs to the D-alanine--D-alanine ligase family
DGM85_21755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGM85_21760	COG0318	PFAM AMP-dependent synthetase and ligase
DGM85_21765	COG0727	PFAM Uncharacterised protein family (UPF0153)
DGM85_21770	COG0596	Alpha beta hydrolase
DGM85_21775	COG3177	Filamentation induced by cAMP protein fic
DGM85_21780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGM85_21795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DGM85_21820	COG2205	protein histidine kinase activity
DGM85_21850	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DGM85_21855	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DGM85_21860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DGM85_21900	COG0183	Belongs to the thiolase family
DGM85_21915	COG2032	superoxide dismutase activity
DGM85_21920	COG2032	superoxide dismutase activity
DGM85_21925	COG2204	response regulator
DGM85_21930	COG3852	Histidine kinase
DGM85_21935	COG0004	ammonium transporteR
DGM85_21940	COG0347	Belongs to the P(II) protein family
DGM85_21945	COG0174	glutamine synthetase
DGM85_21955	COG1968	undecaprenyl-diphosphatase activity
DGM85_22000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGM85_22010	COG2062	phosphohistidine phosphatase, SixA
DGM85_22015	COG0489	protein tyrosine kinase activity
DGM85_22045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGM85_22060	COG1125	glycine betaine transport
DGM85_22060	COG0517	IMP dehydrogenase activity
DGM85_22075	COG1119	ATPase activity
DGM85_22085	COG1752	Esterase of the alpha-beta hydrolase superfamily
DGM85_22095	COG1522	sequence-specific DNA binding
DGM85_22100	COG3186	Phenylalanine-4-hydroxylase
DGM85_22110	COG2755	lipolytic protein G-D-S-L family
DGM85_22120	COG3039	Transposase
DGM85_22125	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_22130	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DGM85_22135	COG1609	Transcriptional regulator
DGM85_22140	COG3507	Belongs to the glycosyl hydrolase 43 family
DGM85_22155	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DGM85_22165	COG2755	lipolytic protein G-D-S-L family
DGM85_22165	COG0657	acetylesterase activity
DGM85_22190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGM85_22195	COG0366	Alpha amylase catalytic
DGM85_22200	COG0366	Alpha amylase catalytic
DGM85_22215	COG3039	Transposase
DGM85_22240	COG3328	transposase activity
DGM85_22260	COG0302	gtp cyclohydrolase
DGM85_22275	COG1566	PFAM secretion protein HlyD family protein
DGM85_22285	COG1289	transmembrane transporter activity
DGM85_22290	COG0477	Major facilitator Superfamily
DGM85_22300	COG0583	DNA-binding transcription factor activity
DGM85_22305	COG4221	oxidoreductase activity
DGM85_22315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGM85_22370	COG0564	pseudouridine synthase activity
DGM85_22475	COG4790	Type iii secretion
DGM85_22630	COG3039	Transposase
DGM85_22660	COG0439	Biotin carboxylase
DGM85_22690	COG1028	Short-chain dehydrogenase reductase Sdr
DGM85_22750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DGM85_22755	COG1074	ATP-dependent DNA helicase activity
DGM85_22760	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DGM85_22795	COG1127	ABC transporter
DGM85_22800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGM85_22805	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGM85_22820	COG2853	Lipoprotein
DGM85_22835	COG0386	Belongs to the glutathione peroxidase family
DGM85_22845	COG1322	Protein conserved in bacteria
DGM85_22855	COG0583	DNA-binding transcription factor activity
DGM85_22875	COG0531	amino acid
DGM85_22880	COG3537	Alpha-1,2-mannosidase
DGM85_22895	COG2199	diguanylate cyclase activity
DGM85_22895	COG2203	Gaf domain
DGM85_22900	COG3835	regulator
DGM85_22905	COG1929	Belongs to the glycerate kinase type-1 family
DGM85_22925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGM85_22935	COG0861	Integral membrane protein TerC family
DGM85_22955	COG0584	glycerophosphoryl diester phosphodiesterase
DGM85_22970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DGM85_22975	COG0726	polysaccharide deacetylase
DGM85_22980	COG0706	membrane insertase activity
DGM85_22985	COG0594	ribonuclease P activity
DGM85_23120	COG3328	transposase activity
DGM85_23165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DGM85_23170	COG4691	Plasmid stability protein
DGM85_23175	COG1487	ribonuclease activity
DGM85_23245	COG3846	protein secretion by the type IV secretion system
DGM85_23255	COG3451	type IV secretory pathway VirB4
DGM85_23270	COG4962	Type ii secretion system protein e
DGM85_23390	COG3328	transposase activity
DGM85_23495	COG3328	transposase activity
DGM85_23510	COG3328	transposase activity
DGM85_23625	COG1487	ribonuclease activity
DGM85_23630	COG4691	Plasmid stability protein
DGM85_23635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs