locus-tag	class	description
M0D43_00005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M0D43_00035	COG1304	FMN binding
M0D43_00040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M0D43_00060	COG0363	glucosamine-6-phosphate deaminase activity
M0D43_00085	COG1238	metal cluster binding
M0D43_00115	COG3279	Response regulator of the LytR AlgR family
M0D43_00120	COG3275	phosphorelay sensor kinase activity
M0D43_00150	COG4566	intracellular signal transduction
M0D43_00160	COG5001	Diguanylate cyclase
M0D43_00190	COG0243	molybdopterin cofactor binding
M0D43_00200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M0D43_00205	COG2223	nitrite transmembrane transporter activity
M0D43_00210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M0D43_00220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M0D43_00220	COG1648	precorrin-2 dehydrogenase activity
M0D43_00230	COG0746	molybdenum cofactor guanylyltransferase activity
M0D43_00235	COG0303	'Molybdopterin
M0D43_00245	COG0708	Exodeoxyribonuclease III
M0D43_00255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M0D43_00260	COG0303	'Molybdopterin
M0D43_00265	COG1160	GTP binding
M0D43_00270	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D43_00290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M0D43_00305	COG1024	Enoyl-CoA hydratase
M0D43_00305	COG1250	3-hydroxyacyl-CoA dehydrogenase
M0D43_00310	COG0183	Belongs to the thiolase family
M0D43_00315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M0D43_00320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M0D43_00340	COG1674	ftsk spoiiie
M0D43_00345	COG0492	ferredoxin-NADP+ reductase activity
M0D43_00355	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M0D43_00365	COG0542	response to heat
M0D43_00385	COG0482	sulfurtransferase activity
M0D43_00415	COG4585	Histidine kinase
M0D43_00425	COG5002	protein histidine kinase activity
M0D43_00445	COG0784	Response regulator, receiver
M0D43_00445	COG0835	chemotaxis
M0D43_00455	COG1558	bacterial-type flagellum-dependent cell motility
M0D43_00460	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M0D43_00470	COG4787	bacterial-type flagellum-dependent cell motility
M0D43_00480	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M0D43_00485	COG1706	bacterial-type flagellum-dependent cell motility
M0D43_00490	COG1705	Flagellar rod assembly protein muramidase FlgJ
M0D43_00490	COG3951	Flagellar rod assembly protein muramidase FlgJ
M0D43_00500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M0D43_00510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M0D43_00515	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M0D43_00540	COG2197	response regulator
M0D43_00550	COG2201	protein-glutamate methylesterase activity
M0D43_00570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D43_00575	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_00580	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_00645	COG1677	Flagellar hook-basal body complex protein FliE
M0D43_00695	COG3190	flagellar
M0D43_00710	COG1684	flagellar biosynthetic protein fliR
M0D43_00765	COG2198	Histidine kinase
M0D43_00765	COG0643	Histidine kinase
M0D43_00765	COG0784	Response regulator, receiver
M0D43_00840	COG0793	Belongs to the peptidase S41A family
M0D43_00845	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M0D43_00850	COG1360	Flagellar Motor Protein
M0D43_00855	COG1192	Involved in chromosome partitioning
M0D43_00860	COG0835	chemotaxis
M0D43_00870	COG0745	RESPONSE REGULATOR receiver
M0D43_00880	COG0840	transmembrane signaling receptor activity
M0D43_00890	COG0840	transmembrane signaling receptor activity
M0D43_00895	COG0840	transmembrane signaling receptor activity
M0D43_00905	COG0840	transmembrane signaling receptor activity
M0D43_00910	COG0840	transmembrane signaling receptor activity
M0D43_00915	COG0840	transmembrane signaling receptor activity
M0D43_00920	COG0840	transmembrane signaling receptor activity
M0D43_00925	COG0840	transmembrane signaling receptor activity
M0D43_00930	COG0840	transmembrane signaling receptor activity
M0D43_00935	COG0840	transmembrane signaling receptor activity
M0D43_00940	COG0840	transmembrane signaling receptor activity
M0D43_00945	COG0840	transmembrane signaling receptor activity
M0D43_00955	COG0835	chemotaxis
M0D43_00965	COG0840	transmembrane signaling receptor activity
M0D43_00995	COG2267	carboxylic ester hydrolase activity
M0D43_01025	COG0318	PFAM AMP-dependent synthetase and ligase
M0D43_01030	COG1024	Enoyl-CoA hydratase
M0D43_01035	COG2198	Histidine kinase
M0D43_01035	COG2205	protein histidine kinase activity
M0D43_01035	COG0784	Response regulator, receiver
M0D43_01045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M0D43_01055	COG3279	Response regulator of the LytR AlgR family
M0D43_01070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M0D43_01080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D43_01085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M0D43_01095	COG0505	Belongs to the CarA family
M0D43_01100	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M0D43_01110	COG2258	MOSC domain
M0D43_01115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M0D43_01160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M0D43_01180	COG0277	FAD linked oxidase domain protein
M0D43_01185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M0D43_01195	COG0531	amino acid
M0D43_01200	COG0531	amino acid
M0D43_01205	COG0235	Class ii aldolase
M0D43_01210	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M0D43_01230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M0D43_01230	COG0140	phosphoribosyl-ATP diphosphatase activity
M0D43_01235	COG0107	imidazoleglycerol-phosphate synthase activity
M0D43_01240	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M0D43_01245	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M0D43_01250	COG0131	Imidazoleglycerol-phosphate dehydratase
M0D43_01250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M0D43_01255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D43_01260	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M0D43_01275	COG0124	histidyl-tRNA synthetase
M0D43_01285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M0D43_01295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M0D43_01360	COG1012	belongs to the aldehyde dehydrogenase family
M0D43_01375	COG0167	dihydroorotate dehydrogenase activity
M0D43_01380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M0D43_01385	COG0697	spore germination
M0D43_01390	COG1794	racemase activity, acting on amino acids and derivatives
M0D43_01400	COG0671	phosphoesterase, PA-phosphatase related
M0D43_01405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M0D43_01415	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
M0D43_01420	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D43_01425	COG5001	Diguanylate cyclase
M0D43_01425	COG4251	negative regulation of phosphorylation
M0D43_01425	COG3706	GGDEF domain
M0D43_01425	COG2203	Gaf domain
M0D43_01435	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D43_01465	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M0D43_01470	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M0D43_01475	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M0D43_01485	COG0617	tRNA 3'-terminal CCA addition
M0D43_01495	COG1469	GTP cyclohydrolase I activity
M0D43_01500	COG0860	N-Acetylmuramoyl-L-alanine amidase
M0D43_01520	COG0477	Major facilitator Superfamily
M0D43_01530	COG1070	Carbohydrate kinase
M0D43_01540	COG1501	Belongs to the glycosyl hydrolase 31 family
M0D43_01580	COG0800	Aldolase
M0D43_01585	COG4948	Mandelate Racemase Muconate Lactonizing
M0D43_01595	COG3734	2-keto-3-deoxy-galactonokinase
M0D43_01600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M0D43_01610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M0D43_01625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M0D43_01630	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M0D43_01645	COG0351	phosphomethylpyrimidine kinase
M0D43_01645	COG0352	thiamine-phosphate diphosphorylase activity
M0D43_01670	COG0583	DNA-binding transcription factor activity
M0D43_01675	COG1741	Belongs to the pirin family
M0D43_01690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M0D43_01695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M0D43_01700	COG2137	regulation of response to DNA damage stimulus
M0D43_01705	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M0D43_01715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D43_01720	COG1546	Belongs to the CinA family
M0D43_01725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M0D43_01735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M0D43_01740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M0D43_01745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M0D43_01750	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M0D43_01755	COG1534	Rna-binding protein
M0D43_01760	COG3737	Protein of unknown function (DUF498/DUF598)
M0D43_01770	COG1238	metal cluster binding
M0D43_01775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M0D43_01780	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M0D43_01785	COG2840	Smr protein MutS2
M0D43_01790	COG0585	pseudouridine synthase activity
M0D43_01795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M0D43_01805	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M0D43_01810	COG0148	phosphopyruvate hydratase activity
M0D43_01825	COG0504	CTP synthase activity
M0D43_01845	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M0D43_01850	COG0306	phosphate transporter
M0D43_01860	COG1253	flavin adenine dinucleotide binding
M0D43_01875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M0D43_01880	COG0477	Major facilitator Superfamily
M0D43_01885	COG1132	(ABC) transporter
M0D43_01890	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M0D43_01905	COG0438	transferase activity, transferring glycosyl groups
M0D43_01915	COG2264	protein methyltransferase activity
M0D43_01920	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M0D43_01945	COG2244	polysaccharide biosynthetic process
M0D43_02010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M0D43_02020	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M0D43_02030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D43_02045	COG0784	Response regulator, receiver
M0D43_02045	COG4191	Histidine kinase
M0D43_02050	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M0D43_02055	COG0784	Response regulator, receiver
M0D43_02055	COG2205	protein histidine kinase activity
M0D43_02055	COG5002	protein histidine kinase activity
M0D43_02075	COG0840	transmembrane signaling receptor activity
M0D43_02090	COG0583	DNA-binding transcription factor activity
M0D43_02095	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M0D43_02100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M0D43_02115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M0D43_02120	COG0077	Prephenate dehydratase
M0D43_02120	COG1605	Chorismate mutase
M0D43_02125	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M0D43_02130	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M0D43_02135	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
M0D43_02170	COG1228	amidohydrolase
M0D43_02175	COG2986	histidine ammonia-lyase
M0D43_02185	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M0D43_02200	COG4993	Dehydrogenase
M0D43_02215	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M0D43_02230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M0D43_02235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M0D43_02240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D43_02250	COG3115	cell septum assembly
M0D43_02270	COG0360	Binds together with S18 to 16S ribosomal RNA
M0D43_02275	COG0316	Belongs to the HesB IscA family
M0D43_02280	COG0017	Asparaginyl-tRNA synthetase
M0D43_02305	COG0288	reversible hydration of carbon dioxide
M0D43_02320	COG3844	kynureninase activity
M0D43_02325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D43_02330	COG2925	Exonuclease
M0D43_02340	COG0667	Aldo Keto reductase
M0D43_02355	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M0D43_02360	COG0116	Belongs to the methyltransferase superfamily
M0D43_02360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M0D43_02410	COG1024	Enoyl-CoA hydratase
M0D43_02420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M0D43_02450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M0D43_02455	COG0573	inorganic phosphate transmembrane transporter activity
M0D43_02460	COG0581	inorganic phosphate transmembrane transporter activity
M0D43_02470	COG0704	Plays a role in the regulation of phosphate uptake
M0D43_02480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M0D43_02490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M0D43_02500	COG0557	exoribonuclease II activity
M0D43_02515	COG1960	acyl-CoA dehydrogenase activity
M0D43_02520	COG2226	methyltransferase
M0D43_02525	COG1410	methionine synthase
M0D43_02525	COG0646	methionine synthase
M0D43_02535	COG1410	methionine synthase
M0D43_02535	COG0646	methionine synthase
M0D43_02545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D43_02570	COG2900	Belongs to the SlyX family
M0D43_02585	COG0386	Belongs to the glutathione peroxidase family
M0D43_02595	COG1725	Transcriptional regulator
M0D43_02600	COG1131	(ABC) transporter
M0D43_02635	COG1253	flavin adenine dinucleotide binding
M0D43_02660	COG2850	peptidyl-arginine hydroxylation
M0D43_02700	COG1132	(ABC) transporter
M0D43_02710	COG0583	DNA-binding transcription factor activity
M0D43_02740	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M0D43_02755	COG0443	Heat shock 70 kDa protein
M0D43_02760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M0D43_02765	COG1420	regulation of RNA biosynthetic process
M0D43_02770	COG0497	DNA recombination
M0D43_02780	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D43_02785	COG2914	Belongs to the UPF0125 (RnfH) family
M0D43_02795	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M0D43_02810	COG0582	viral genome integration into host DNA
M0D43_02890	COG1196	nuclear chromosome segregation
M0D43_03060	COG0305	Participates in initiation and elongation during chromosome replication
M0D43_03245	COG2814	Major facilitator Superfamily
M0D43_03380	COG2003	Belongs to the UPF0758 family
M0D43_03455	COG3706	GGDEF domain
M0D43_03485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D43_03500	COG0583	DNA-binding transcription factor activity
M0D43_03510	COG0415	Belongs to the DNA photolyase family
M0D43_03515	COG0305	Participates in initiation and elongation during chromosome replication
M0D43_03525	COG0367	asparagine synthase
M0D43_03545	COG1960	acyl-CoA dehydrogenase activity
M0D43_03560	COG0084	hydrolase, TatD family'
M0D43_03565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M0D43_03605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M0D43_03660	COG0386	Belongs to the glutathione peroxidase family
M0D43_03665	COG0339	signal peptide processing
M0D43_03745	COG2814	Major facilitator Superfamily
M0D43_03750	COG1566	PFAM secretion protein HlyD family protein
M0D43_03775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M0D43_03795	COG0300	oxidoreductase activity
M0D43_03800	COG4774	siderophore transport
M0D43_03810	COG0367	asparagine synthase
M0D43_03815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D43_03825	COG1393	Belongs to the ArsC family
M0D43_03840	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M0D43_03885	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M0D43_03895	COG0528	UMP kinase activity
M0D43_03900	COG0233	cytoplasmic translational termination
M0D43_03910	COG0575	Belongs to the CDS family
M0D43_03915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M0D43_03920	COG0750	zinc metalloprotease
M0D43_03935	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D43_03945	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D43_03950	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D43_03955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M0D43_03965	COG0825	malonyl-CoA metabolic process
M0D43_03990	COG1981	membrane
M0D43_04010	COG1695	Transcriptional regulator
M0D43_04030	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M0D43_04050	COG2040	homocysteine
M0D43_04055	COG0833	amino acid
M0D43_04060	COG0346	lactoylglutathione lyase activity
M0D43_04065	COG1131	(ABC) transporter
M0D43_04080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D43_04080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D43_04090	COG2878	Part of a membrane complex involved in electron transport
M0D43_04105	COG1595	DNA-templated transcription, initiation
M0D43_04130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M0D43_04155	COG0251	oxidation-reduction process
M0D43_04165	COG0392	lysyltransferase activity
M0D43_04165	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M0D43_04200	COG2814	Major facilitator Superfamily
M0D43_04205	COG1902	pentaerythritol trinitrate reductase activity
M0D43_04210	COG2824	Alkylphosphonate utilization operon protein PhnA
M0D43_04220	COG1047	Peptidyl-prolyl cis-trans
M0D43_04255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M0D43_04265	COG5487	UPF0391 membrane protein
M0D43_04270	COG1451	nucleotide metabolic process
M0D43_04295	COG0183	Belongs to the thiolase family
M0D43_04325	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M0D43_04325	COG1793	dna ligase
M0D43_04335	COG1793	dna ligase
M0D43_04340	COG1201	RNA secondary structure unwinding
M0D43_04360	COG1278	Cold shock
M0D43_04365	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M0D43_04370	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M0D43_04375	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D43_04380	COG3046	protein related to deoxyribodipyrimidine photolyase
M0D43_04385	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
M0D43_04390	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M0D43_04395	COG2954	triphosphatase activity
M0D43_04410	COG1381	Involved in DNA repair and RecF pathway recombination
M0D43_04420	COG0571	ribonuclease III activity
M0D43_04435	COG0481	GTPase activity
M0D43_04440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M0D43_04480	COG1024	Enoyl-CoA hydratase
M0D43_04485	COG1960	acyl-CoA dehydrogenase activity
M0D43_04505	COG3867	Arabinogalactan endo-beta-1,4-galactanase
M0D43_04510	COG3250	beta-galactosidase activity
M0D43_04525	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M0D43_04530	COG1121	(ABC) transporter
M0D43_04540	COG0803	Belongs to the bacterial solute-binding protein 9 family
M0D43_04545	COG0523	cobalamin synthesis protein
M0D43_04555	COG4774	siderophore transport
M0D43_04575	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M0D43_04585	COG0534	Mate efflux family protein
M0D43_04595	COG0336	Belongs to the RNA methyltransferase TrmD family
M0D43_04600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M0D43_04605	COG0228	four-way junction DNA binding
M0D43_04615	COG2070	2-Nitropropane dioxygenase
M0D43_04625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M0D43_04630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M0D43_04645	COG0583	DNA-binding transcription factor activity
M0D43_04665	COG4191	Histidine kinase
M0D43_04665	COG0784	Response regulator, receiver
M0D43_04670	COG3437	response regulator, receiver
M0D43_04670	COG3850	Histidine kinase
M0D43_04670	COG4999	Histidine kinase
M0D43_04670	COG2205	protein histidine kinase activity
M0D43_04675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M0D43_04690	COG5507	3-demethylubiquinone-9 3-methyltransferase
M0D43_04700	COG4771	TonB-dependent receptor
M0D43_04725	COG2172	sigma factor antagonist activity
M0D43_04730	COG1366	Belongs to the anti-sigma-factor antagonist family
M0D43_04735	COG1366	Belongs to the anti-sigma-factor antagonist family
M0D43_04745	COG0326	Molecular chaperone. Has ATPase activity
M0D43_04750	COG2207	Transcriptional regulator
M0D43_04760	COG3152	Membrane
M0D43_04770	COG0156	8-amino-7-oxononanoate synthase activity
M0D43_04780	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M0D43_04785	COG1845	cytochrome c oxidase, subunit III
M0D43_04790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M0D43_04810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M0D43_04815	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M0D43_04830	COG0268	Binds directly to 16S ribosomal RNA
M0D43_04840	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M0D43_04850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M0D43_04855	COG0824	Thioesterase
M0D43_04870	COG1946	Acyl-CoA thioesterase
M0D43_04880	COG1595	DNA-templated transcription, initiation
M0D43_04895	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M0D43_04915	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M0D43_04940	COG1073	alpha beta
M0D43_04960	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M0D43_04975	COG2197	response regulator
M0D43_04980	COG4585	Histidine kinase
M0D43_04995	COG2894	cell division
M0D43_05000	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M0D43_05010	COG0642	Histidine kinase
M0D43_05015	COG0745	RESPONSE REGULATOR receiver
M0D43_05020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M0D43_05030	COG2194	sulfuric ester hydrolase activity
M0D43_05045	COG2814	Major facilitator Superfamily
M0D43_05070	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M0D43_05070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M0D43_05080	COG0656	L-ascorbic acid biosynthetic process
M0D43_05085	COG0753	catalase activity
M0D43_05110	COG1917	Cupin 2, conserved barrel domain protein
M0D43_05110	COG2207	Transcriptional regulator
M0D43_05120	COG0823	Involved in the tonB-independent uptake of proteins
M0D43_05120	COG1506	peptidase
M0D43_05130	COG1297	OPT oligopeptide transporter protein
M0D43_05155	COG0587	DNA-directed DNA polymerase activity
M0D43_05205	COG2080	2 iron, 2 sulfur cluster binding
M0D43_05210	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M0D43_05215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M0D43_05225	COG1064	alcohol dehydrogenase
M0D43_05260	COG3537	Alpha-1,2-mannosidase
M0D43_05270	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_05310	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
M0D43_05320	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M0D43_05325	COG0732	type I restriction modification DNA specificity domain
M0D43_05340	COG1309	transcriptional regulator
M0D43_05345	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_05360	COG0308	aminopeptidase N
M0D43_05380	COG0330	HflC and HflK could
M0D43_05385	COG0330	HflC and HflK could
M0D43_05405	COG0678	peroxiredoxin activity
M0D43_05415	COG4953	penicillin-binding protein 1C
M0D43_05430	COG2373	Large extracellular alpha-helical protein
M0D43_05455	COG3609	addiction module antidote protein, CC2985 family
M0D43_05475	COG3829	transcription factor binding
M0D43_05500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M0D43_05505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M0D43_05515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M0D43_05535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D43_05540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M0D43_05545	COG1399	metal-binding, possibly nucleic acid-binding protein
M0D43_05565	COG0714	Associated with various cellular activities
M0D43_05585	COG0537	adenosine 5'-monophosphoramidase activity
M0D43_05595	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M0D43_05655	COG0314	molybdopterin synthase activity
M0D43_05660	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M0D43_05665	COG0315	cyclic pyranopterin monophosphate synthase activity
M0D43_05675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M0D43_05685	COG3642	lipopolysaccharide core region biosynthetic process
M0D43_05690	COG0859	PFAM glycosyl transferase family 9
M0D43_05705	COG0631	protein serine/threonine phosphatase activity
M0D43_05715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M0D43_05740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M0D43_05770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M0D43_05780	COG0544	peptidyl-prolyl cis-trans isomerase activity
M0D43_05790	COG0784	Response regulator, receiver
M0D43_05790	COG4191	Histidine kinase
M0D43_05825	COG0473	3-isopropylmalate dehydrogenase activity
M0D43_05840	COG4783	chaperone-mediated protein folding
M0D43_05855	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M0D43_05865	COG0438	transferase activity, transferring glycosyl groups
M0D43_05870	COG0671	phosphoesterase, PA-phosphatase related
M0D43_05875	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D43_05885	COG3291	Pkd domain containing protein
M0D43_05890	COG2833	Protein of unknown function (DUF455)
M0D43_05915	COG0285	dihydrofolate synthase activity
M0D43_05930	COG0406	alpha-ribazole phosphatase activity
M0D43_05960	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M0D43_05965	COG4208	sulfate ABC transporter
M0D43_05970	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M0D43_05975	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M0D43_05980	COG0156	8-amino-7-oxononanoate synthase activity
M0D43_06000	COG2885	chlorophyll binding
M0D43_06005	COG0604	alcohol dehydrogenase
M0D43_06010	COG0446	pyridine nucleotide-disulphide oxidoreductase
M0D43_06010	COG1902	pentaerythritol trinitrate reductase activity
M0D43_06025	COG0625	glutathione transferase activity
M0D43_06035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M0D43_06040	COG1217	gtp-binding protein TYPA
M0D43_06050	COG0154	amidase activity
M0D43_06060	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M0D43_06070	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M0D43_06075	COG0203	ribosomal protein L17
M0D43_06100	COG0201	protein transport
M0D43_06105	COG0200	Binds to the 23S rRNA
M0D43_06110	COG1841	ribosomal large subunit assembly
M0D43_06125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M0D43_06145	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M0D43_06155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M0D43_06160	COG0255	Belongs to the universal ribosomal protein uL29 family
M0D43_06175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M0D43_06185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M0D43_06195	COG0088	Forms part of the polypeptide exit tunnel
M0D43_06205	COG0051	transcription antitermination factor activity, RNA binding
M0D43_06220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M0D43_06225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M0D43_06230	COG0049	tRNA binding
M0D43_06235	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M0D43_06240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M0D43_06245	COG0085	RNA polymerase activity
M0D43_06255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M0D43_06260	COG0081	regulation of translation
M0D43_06265	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M0D43_06270	COG0250	Participates in transcription elongation, termination and antitermination
M0D43_06275	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M0D43_06285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M0D43_06305	COG0012	GTP binding
M0D43_06310	COG0193	aminoacyl-tRNA hydrolase activity
M0D43_06315	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M0D43_06320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M0D43_06335	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M0D43_06345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M0D43_06350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M0D43_06360	COG0521	Mo-molybdopterin cofactor biosynthetic process
M0D43_06380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D43_06385	COG1295	ribonuclease BN
M0D43_06415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M0D43_06420	COG1404	Belongs to the peptidase S8 family
M0D43_06425	COG1404	Belongs to the peptidase S8 family
M0D43_06430	COG1404	Belongs to the peptidase S8 family
M0D43_06435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M0D43_06450	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M0D43_06475	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M0D43_06540	COG3634	alkyl hydroperoxide reductase activity
M0D43_06545	COG0583	DNA-binding transcription factor activity
M0D43_06555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D43_06560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M0D43_06570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M0D43_06580	COG2197	response regulator
M0D43_06585	COG2205	protein histidine kinase activity
M0D43_06585	COG0784	Response regulator, receiver
M0D43_06585	COG5002	protein histidine kinase activity
M0D43_06605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D43_06610	COG0697	spore germination
M0D43_06655	COG1024	Enoyl-CoA hydratase
M0D43_06665	COG0318	PFAM AMP-dependent synthetase and ligase
M0D43_06670	COG0583	DNA-binding transcription factor activity
M0D43_06675	COG3384	dioxygenase
M0D43_06685	COG1802	Transcriptional regulator
M0D43_06700	COG2267	carboxylic ester hydrolase activity
M0D43_06705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D43_06710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D43_06725	COG2096	Adenosyltransferase
M0D43_06730	COG0123	including yeast histone deacetylase and acetoin utilization protein
M0D43_06735	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M0D43_06745	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M0D43_06750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M0D43_06755	COG2967	ApaG domain
M0D43_06760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M0D43_06780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M0D43_06800	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M0D43_06810	COG0642	Histidine kinase
M0D43_06825	COG4181	ATPase activity
M0D43_06835	COG2175	clavaminate synthase activity
M0D43_06845	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M0D43_06850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M0D43_06870	COG4771	TonB-dependent receptor
M0D43_06880	COG0667	Aldo Keto reductase
M0D43_06890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M0D43_06895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D43_06910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M0D43_06915	COG4106	trans-aconitate 2-methyltransferase activity
M0D43_06925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M0D43_06965	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M0D43_06980	COG2226	methyltransferase
M0D43_07020	COG0366	Alpha amylase catalytic
M0D43_07040	COG3321	synthase
M0D43_07040	COG0604	alcohol dehydrogenase
M0D43_07040	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_07050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M0D43_07060	COG0494	nUDIX hydrolase
M0D43_07070	COG0653	protein targeting
M0D43_07075	COG0739	heme binding
M0D43_07085	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M0D43_07100	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M0D43_07105	COG1181	Belongs to the D-alanine--D-alanine ligase family
M0D43_07110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M0D43_07115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M0D43_07125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M0D43_07130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M0D43_07145	COG3116	cell division
M0D43_07190	COG0792	nuclease activity
M0D43_07195	COG1988	membrane-bound metal-dependent
M0D43_07200	COG0277	FAD linked oxidase domain protein
M0D43_07215	COG0745	RESPONSE REGULATOR receiver
M0D43_07220	COG2205	protein histidine kinase activity
M0D43_07230	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M0D43_07235	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M0D43_07255	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M0D43_07260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M0D43_07265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M0D43_07285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M0D43_07285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M0D43_07300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M0D43_07315	COG0488	(ABC) transporter
M0D43_07320	COG0242	peptide deformylase activity
M0D43_07345	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M0D43_07390	COG2188	Transcriptional regulator
M0D43_07400	COG1450	Type ii and iii secretion system protein
M0D43_07415	COG3166	PFAM Fimbrial assembly family protein
M0D43_07420	COG3156	type II secretion system protein K
M0D43_07425	COG4795	General secretion pathway protein
M0D43_07430	COG2165	general secretion pathway protein
M0D43_07435	COG4970	Tfp pilus assembly protein FimT
M0D43_07440	COG2165	general secretion pathway protein
M0D43_07445	COG1459	type II secretion system
M0D43_07450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M0D43_07455	COG1404	Belongs to the peptidase S8 family
M0D43_07460	COG5295	Hep Hag repeat protein
M0D43_07470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M0D43_07470	COG0047	phosphoribosylformylglycinamidine synthase activity
M0D43_07475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M0D43_07480	COG4974	Belongs to the 'phage' integrase family
M0D43_07500	COG0795	lipopolysaccharide-transporting ATPase activity
M0D43_07510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M0D43_07525	COG0525	valine-tRNA ligase activity
M0D43_07555	COG0726	polysaccharide deacetylase
M0D43_07555	COG1649	PFAM Uncharacterised BCR, COG1649
M0D43_07560	COG1215	transferase activity, transferring glycosyl groups
M0D43_07575	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M0D43_07580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M0D43_07585	COG1609	Transcriptional regulator
M0D43_07595	COG2188	Transcriptional regulator
M0D43_07610	COG3250	beta-galactosidase activity
M0D43_07640	COG4795	General secretion pathway protein
M0D43_07660	COG1459	type II secretion system
M0D43_07715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M0D43_07720	COG4191	Histidine kinase
M0D43_07725	COG0784	Response regulator, receiver
M0D43_07730	COG4251	negative regulation of phosphorylation
M0D43_07735	COG2823	Periplasmic or secreted lipoprotein
M0D43_07740	COG0673	inositol 2-dehydrogenase activity
M0D43_07745	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M0D43_07780	COG1056	cytidyltransferase-related domain
M0D43_07780	COG1051	belongs to the nudix hydrolase family
M0D43_07790	COG0583	DNA-binding transcription factor activity
M0D43_07805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M0D43_07810	COG0321	lipoyl(octanoyl) transferase activity
M0D43_07815	COG2921	Belongs to the UPF0250 family
M0D43_07825	COG1686	Belongs to the peptidase S11 family
M0D43_07830	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M0D43_07835	COG2951	lytic endotransglycosylase activity
M0D43_07840	COG5434	Belongs to the glycosyl hydrolase 28 family
M0D43_07850	COG0772	Belongs to the SEDS family
M0D43_07865	COG1792	Involved in formation and maintenance of cell shape
M0D43_07875	COG1077	Cell shape determining protein MreB Mrl
M0D43_07880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D43_07895	COG3284	Transcriptional regulator
M0D43_07940	COG0308	aminopeptidase N
M0D43_07945	COG5001	Diguanylate cyclase
M0D43_07945	COG3300	MHYT domain
M0D43_07950	COG2226	methyltransferase
M0D43_07965	COG2153	protein acetylation
M0D43_07975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M0D43_07985	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M0D43_07995	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M0D43_08005	COG2832	Protein of unknown function (DUF454)
M0D43_08015	COG0436	Aminotransferase
M0D43_08030	COG1505	serine-type exopeptidase activity
M0D43_08055	COG0181	hydroxymethylbilane synthase activity
M0D43_08065	COG3275	phosphorelay sensor kinase activity
M0D43_08075	COG2943	transferase activity, transferring hexosyl groups
M0D43_08090	COG0659	secondary active sulfate transmembrane transporter activity
M0D43_08095	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D43_08095	COG5297	Belongs to the glycosyl hydrolase family 6
M0D43_08100	COG0840	transmembrane signaling receptor activity
M0D43_08165	COG0598	Magnesium transport protein CorA
M0D43_08175	COG1113	amino acid transport
M0D43_08185	COG5297	Belongs to the glycosyl hydrolase family 6
M0D43_08190	COG4305	rare lipoprotein A
M0D43_08195	COG0697	spore germination
M0D43_08260	COG0435	Glutathione S-transferase
M0D43_08270	COG4221	oxidoreductase activity
M0D43_08315	COG0210	DNA helicase
M0D43_08420	COG1802	Transcriptional regulator
M0D43_08430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M0D43_08455	COG3052	prosthetic group binding
M0D43_08490	COG1595	DNA-templated transcription, initiation
M0D43_08495	COG2353	YceI-like domain
M0D43_08500	COG0778	Nitroreductase
M0D43_08525	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M0D43_08530	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M0D43_08540	COG3386	PFAM SMP-30 Gluconolaconase
M0D43_08555	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M0D43_08570	COG3039	Transposase
M0D43_08605	COG0459	protein refolding
M0D43_08615	COG2356	endonuclease I
M0D43_08620	COG1324	tolerance protein
M0D43_08630	COG1505	serine-type exopeptidase activity
M0D43_08635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M0D43_08640	COG0511	ligase activity, forming carbon-carbon bonds
M0D43_08650	COG0439	Biotin carboxylase
M0D43_08695	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M0D43_08710	COG0138	bifunctional purine biosynthesis protein purh
M0D43_08715	COG0151	Belongs to the GarS family
M0D43_08720	COG1289	transmembrane transporter activity
M0D43_08725	COG2814	Major facilitator Superfamily
M0D43_08735	COG2814	Major facilitator Superfamily
M0D43_08750	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M0D43_08765	COG0316	Belongs to the HesB IscA family
M0D43_08820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M0D43_08830	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
M0D43_08845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M0D43_08855	COG0134	indole-3-glycerol-phosphate synthase activity
M0D43_08860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M0D43_08890	COG1597	lipid kinase activity
M0D43_08895	COG0456	acetyltransferase
M0D43_08900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M0D43_08910	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M0D43_08950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M0D43_08950	COG2111	Na H antiporter
M0D43_08955	COG1006	Multisubunit Na H antiporter MnhC subunit
M0D43_08960	COG0651	ATP synthesis coupled electron transport
M0D43_08970	COG2212	antiporter activity
M0D43_08975	COG1320	monovalent cation:proton antiporter activity
M0D43_08995	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M0D43_09015	COG3104	oligopeptide transport
M0D43_09030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M0D43_09055	COG0513	Belongs to the DEAD box helicase family
M0D43_09075	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_09095	COG0702	epimerase
M0D43_09120	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M0D43_09125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M0D43_09130	COG0297	glycogen (starch) synthase activity
M0D43_09140	COG1649	PFAM Uncharacterised BCR, COG1649
M0D43_09145	COG2354	Protein conserved in bacteria
M0D43_09150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D43_09155	COG1368	sulfuric ester hydrolase activity
M0D43_09160	COG3264	Mechanosensitive ion channel
M0D43_09160	COG1511	domain protein
M0D43_09235	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M0D43_09315	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M0D43_09320	COG1040	competence protein
M0D43_09325	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M0D43_09330	COG0156	8-amino-7-oxononanoate synthase activity
M0D43_09345	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_09370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M0D43_09385	COG0445	tRNA wobble uridine modification
M0D43_09395	COG0657	acetylesterase activity
M0D43_09405	COG1414	Transcriptional regulator
M0D43_09420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M0D43_09425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D43_09435	COG3485	protocatechuate 3,4-dioxygenase
M0D43_09440	COG3485	protocatechuate 3,4-dioxygenase
M0D43_09450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M0D43_09455	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M0D43_09485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M0D43_09490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M0D43_09545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M0D43_09555	COG0129	dihydroxy-acid dehydratase activity
M0D43_09600	COG1733	regulation of RNA biosynthetic process
M0D43_09605	COG0702	epimerase
M0D43_09635	COG0583	DNA-binding transcription factor activity
M0D43_09640	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M0D43_09695	COG1902	pentaerythritol trinitrate reductase activity
M0D43_09700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M0D43_09705	COG0596	Alpha beta hydrolase
M0D43_09720	COG2814	Major facilitator Superfamily
M0D43_09725	COG0583	DNA-binding transcription factor activity
M0D43_09730	COG0084	hydrolase, TatD family'
M0D43_09750	COG2252	PERMEase
M0D43_09795	COG0596	Alpha beta hydrolase
M0D43_09810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M0D43_09830	COG2072	flavoprotein involved in K transport
M0D43_09835	COG2351	hydroxyisourate hydrolase activity
M0D43_09840	COG4807	Protein conserved in bacteria
M0D43_09850	COG1643	Atp-dependent helicase
M0D43_09860	COG1187	pseudouridine synthase activity
M0D43_09875	COG2130	NADP-dependent
M0D43_09880	COG0656	L-ascorbic acid biosynthetic process
M0D43_09900	COG1764	response to oxidative stress
M0D43_09905	COG1846	Transcriptional regulator
M0D43_09910	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M0D43_09920	COG0697	spore germination
M0D43_09930	COG0523	cobalamin synthesis protein
M0D43_09985	COG1960	acyl-CoA dehydrogenase activity
M0D43_09990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M0D43_09995	COG4770	biotin carboxylase activity
M0D43_10025	COG2224	Isocitrate lyase
M0D43_10030	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M0D43_10035	COG0583	DNA-binding transcription factor activity
M0D43_10040	COG0475	glutathione-regulated potassium exporter activity
M0D43_10070	COG0681	Belongs to the peptidase S26 family
M0D43_10075	COG0339	signal peptide processing
M0D43_10080	COG1446	asparaginase
M0D43_10100	COG0564	pseudouridine synthase activity
M0D43_10115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D43_10125	COG1181	Belongs to the D-alanine--D-alanine ligase family
M0D43_10135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D43_10140	COG0318	PFAM AMP-dependent synthetase and ligase
M0D43_10145	COG0727	PFAM Uncharacterised protein family (UPF0153)
M0D43_10150	COG0596	Alpha beta hydrolase
M0D43_10160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D43_10175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M0D43_10200	COG2205	protein histidine kinase activity
M0D43_10205	COG0028	Belongs to the TPP enzyme family
M0D43_10215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M0D43_10220	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M0D43_10225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M0D43_10265	COG0183	Belongs to the thiolase family
M0D43_10280	COG2032	superoxide dismutase activity
M0D43_10285	COG2032	superoxide dismutase activity
M0D43_10290	COG2204	response regulator
M0D43_10295	COG3852	Histidine kinase
M0D43_10300	COG0004	ammonium transporteR
M0D43_10305	COG0347	Belongs to the P(II) protein family
M0D43_10310	COG0174	glutamine synthetase
M0D43_10315	COG1968	undecaprenyl-diphosphatase activity
M0D43_10355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D43_10365	COG2062	phosphohistidine phosphatase, SixA
M0D43_10370	COG0489	protein tyrosine kinase activity
M0D43_10390	COG3620	sequence-specific DNA binding
M0D43_10395	COG3550	peptidyl-serine autophosphorylation
M0D43_10400	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
M0D43_10405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M0D43_10420	COG0517	IMP dehydrogenase activity
M0D43_10420	COG1125	glycine betaine transport
M0D43_10435	COG1119	ATPase activity
M0D43_10445	COG1473	amidohydrolase
M0D43_10450	COG1752	Esterase of the alpha-beta hydrolase superfamily
M0D43_10460	COG1522	sequence-specific DNA binding
M0D43_10465	COG3186	Phenylalanine-4-hydroxylase
M0D43_10475	COG2755	lipolytic protein G-D-S-L family
M0D43_10485	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_10490	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M0D43_10495	COG1609	Transcriptional regulator
M0D43_10515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M0D43_10525	COG2755	lipolytic protein G-D-S-L family
M0D43_10525	COG0657	acetylesterase activity
M0D43_10535	COG2755	lipolytic protein G-D-S-L family
M0D43_10575	COG0366	Alpha amylase catalytic
M0D43_10580	COG0366	Alpha amylase catalytic
M0D43_10585	COG2831	hemolysin activation secretion protein
M0D43_10595	COG3210	domain, Protein
M0D43_10605	COG3210	domain, Protein
M0D43_10620	COG3210	domain, Protein
M0D43_10665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M0D43_10705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D43_10715	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M0D43_10720	COG3710	Transcriptional regulator
M0D43_10740	COG2197	response regulator
M0D43_10745	COG4585	Histidine kinase
M0D43_10750	COG1755	Isoprenylcysteine carboxyl methyltransferase
M0D43_10755	COG1304	FMN binding
M0D43_10780	COG1012	belongs to the aldehyde dehydrogenase family
M0D43_10785	COG4772	TonB-dependent receptor
M0D43_10795	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M0D43_10845	COG0714	Associated with various cellular activities
M0D43_10885	COG0477	Major facilitator Superfamily
M0D43_10890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D43_10950	COG3237	CsbD-like
M0D43_10960	COG0625	glutathione transferase activity
M0D43_10970	COG1272	protein, Hemolysin III
M0D43_10975	COG1205	dead DEAH box helicase
M0D43_10975	COG1111	helicase
M0D43_11055	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M0D43_11085	COG1132	(ABC) transporter
M0D43_11115	COG0367	asparagine synthase
M0D43_11135	COG0297	glycogen (starch) synthase activity
M0D43_11135	COG0438	transferase activity, transferring glycosyl groups
M0D43_11140	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M0D43_11160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M0D43_11180	COG3459	Glycosyltransferase 36 associated
M0D43_11220	COG0069	glutamate synthase activity
M0D43_11220	COG0070	glutamate synthase
M0D43_11220	COG0067	glutamate synthase
M0D43_11225	COG0493	'glutamate synthase
M0D43_11240	COG1064	alcohol dehydrogenase
M0D43_11245	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D43_11250	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D43_11255	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D43_11265	COG2234	aminopeptidase activity
M0D43_11275	COG4942	peptidase
M0D43_11280	COG0793	Belongs to the peptidase S41A family
M0D43_11285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M0D43_11325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D43_11335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M0D43_11370	COG0501	Belongs to the peptidase M48B family
M0D43_11380	COG0187	DNA topoisomerase II activity
M0D43_11395	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M0D43_11415	COG0726	polysaccharide deacetylase
M0D43_11420	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M0D43_11435	COG0584	glycerophosphoryl diester phosphodiesterase
M0D43_11445	COG0861	Integral membrane protein TerC family
M0D43_11450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M0D43_11465	COG2271	Major facilitator Superfamily
M0D43_11470	COG1929	Belongs to the glycerate kinase type-1 family
M0D43_11475	COG3835	regulator
M0D43_11480	COG3706	GGDEF domain
M0D43_11500	COG3537	Alpha-1,2-mannosidase
M0D43_11505	COG0531	amino acid
M0D43_11525	COG0583	DNA-binding transcription factor activity
M0D43_11530	COG0604	alcohol dehydrogenase
M0D43_11535	COG1322	Protein conserved in bacteria
M0D43_11545	COG0386	Belongs to the glutathione peroxidase family
M0D43_11555	COG2853	Lipoprotein
M0D43_11575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M0D43_11580	COG1127	ABC transporter
M0D43_11585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M0D43_11590	COG1074	ATP-dependent DNA helicase activity
M0D43_11635	COG0564	pseudouridine synthase activity
M0D43_11680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D43_11715	COG0477	Major facilitator Superfamily
M0D43_11720	COG1289	transmembrane transporter activity
M0D43_11730	COG1566	PFAM secretion protein HlyD family protein
M0D43_11745	COG0302	gtp cyclohydrolase
M0D43_11765	COG0730	response to heat
M0D43_11770	COG3012	SEC-C Motif Domain Protein
M0D43_11780	COG0676	glucose-6-phosphate 1-epimerase activity
M0D43_11800	COG3135	benzoate transporter
M0D43_11830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M0D43_11840	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M0D43_11850	COG1435	thymidine kinase activity
M0D43_11855	COG0210	DNA helicase
M0D43_11870	COG3132	Protein of unknown function, DUF480
M0D43_11875	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M0D43_11880	COG0284	orotidine-5'-phosphate decarboxylase activity
M0D43_11910	COG2937	Belongs to the GPAT DAPAT family
M0D43_11965	COG2211	Major facilitator Superfamily
M0D43_11980	COG3693	PFAM glycoside hydrolase, family 10
M0D43_12000	COG1904	glucuronate isomerase
M0D43_12005	COG3250	beta-galactosidase activity
M0D43_12020	COG3386	PFAM SMP-30 Gluconolaconase
M0D43_12045	COG0246	Mannitol dehydrogenase
M0D43_12050	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D43_12060	COG4948	Mandelate Racemase Muconate Lactonizing
M0D43_12070	COG3661	Belongs to the glycosyl hydrolase 67 family
M0D43_12090	COG2974	May be involved in recombination
M0D43_12105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M0D43_12115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M0D43_12120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M0D43_12125	COG0805	protein transport
M0D43_12135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M0D43_12135	COG0519	Catalyzes the synthesis of GMP from XMP
M0D43_12145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M0D43_12150	COG0752	glycyl-tRNA synthetase alpha subunit
M0D43_12160	COG0457	Tetratricopeptide repeat
M0D43_12165	COG4771	TonB-dependent receptor
M0D43_12170	COG0729	surface antigen
M0D43_12175	COG2911	Protein conserved in bacteria
M0D43_12195	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D43_12200	COG3265	gluconokinase activity
M0D43_12205	COG2211	Major facilitator Superfamily
M0D43_12210	COG3459	Glycosyltransferase 36 associated
M0D43_12220	COG2205	protein histidine kinase activity
M0D43_12240	COG1414	Transcriptional regulator
M0D43_12245	COG0738	Major facilitator superfamily
M0D43_12250	COG3254	rhamnose metabolic process
M0D43_12255	COG4948	Mandelate Racemase Muconate Lactonizing
M0D43_12260	COG0179	Fumarylacetoacetate (FAA) hydrolase
M0D43_12265	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_12315	COG3162	membrane
M0D43_12320	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M0D43_12325	COG1940	carbohydrate kinase activity
M0D43_12345	COG2091	lysine biosynthetic process via aminoadipic acid
M0D43_12355	COG3540	Alkaline phosphatase
M0D43_12360	COG0357	Ribosomal RNA small subunit methyltransferase G
M0D43_12380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D43_12405	COG2159	amidohydrolase
M0D43_12415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M0D43_12420	COG0583	DNA-binding transcription factor activity
M0D43_12425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D43_12440	COG0210	DNA helicase
M0D43_12530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M0D43_12530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M0D43_12540	COG0408	coproporphyrinogen oxidase activity
M0D43_12555	COG1506	peptidase
M0D43_12555	COG4946	Tricorn protease homolog
M0D43_12555	COG0823	Involved in the tonB-independent uptake of proteins
M0D43_12570	COG0644	oxidoreductase
M0D43_12575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M0D43_12615	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_12635	COG0463	Glycosyl transferase, family 2
M0D43_12645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M0D43_12650	COG3100	YcgL domain-containing protein
M0D43_12665	COG3387	PFAM Glycoside hydrolase 15-related
M0D43_12670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M0D43_12700	COG2239	Acts as a magnesium transporter
M0D43_12710	COG0045	succinate-CoA ligase (ADP-forming) activity
M0D43_12710	COG1042	CoA-binding domain protein
M0D43_12710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M0D43_12720	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M0D43_12725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M0D43_12755	COG1607	acyl-coa hydrolase
M0D43_12770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M0D43_12775	COG0842	Transport permease protein
M0D43_12780	COG1131	(ABC) transporter
M0D43_12785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M0D43_12805	COG1476	TRANSCRIPTIONal
M0D43_12815	COG4555	ABC transporter
M0D43_12850	COG0625	glutathione transferase activity
M0D43_12945	COG1199	ATP-dependent helicase activity
M0D43_12975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M0D43_13020	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M0D43_13035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M0D43_13075	COG3237	CsbD-like
M0D43_13080	COG0180	Tryptophanyl-tRNA synthetase
M0D43_13105	COG0697	spore germination
M0D43_13130	COG1136	(ABC) transporter
M0D43_13135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D43_13140	COG4585	Histidine kinase
M0D43_13145	COG2197	response regulator
M0D43_13160	COG0753	catalase activity
M0D43_13165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M0D43_13170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D43_13175	COG0628	permease
M0D43_13195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M0D43_13205	COG1090	epimerase
M0D43_13240	COG1690	Belongs to the RtcB family
M0D43_13270	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M0D43_13285	COG0606	chelatase, subunit chli
M0D43_13300	COG3291	Pkd domain containing protein
M0D43_13300	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M0D43_13320	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M0D43_13325	COG1166	arginine decarboxylase activity
M0D43_13330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M0D43_13340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M0D43_13340	COG2755	lipolytic protein G-D-S-L family
M0D43_13345	COG4221	oxidoreductase activity
M0D43_13360	COG0018	arginyl-trna synthetase
M0D43_13365	COG2003	Belongs to the UPF0758 family
M0D43_13370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M0D43_13395	COG0463	Glycosyl transferase, family 2
M0D43_13410	COG1475	DNA binding
M0D43_13415	COG1192	Involved in chromosome partitioning
M0D43_13430	COG0708	Exodeoxyribonuclease III
M0D43_13435	COG2223	nitrite transmembrane transporter activity
M0D43_13450	COG0739	heme binding
M0D43_13495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M0D43_13510	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M0D43_13560	COG0358	DNA primase activity
M0D43_13565	COG1295	ribonuclease BN
M0D43_13575	COG1610	YqeY-like protein
M0D43_13585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M0D43_13590	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M0D43_13600	COG2133	pyrroloquinoline quinone binding
M0D43_13605	COG4682	membrane
M0D43_13620	COG0531	amino acid
M0D43_13630	COG4948	Mandelate Racemase Muconate Lactonizing
M0D43_13640	COG3023	N-Acetylmuramoyl-L-alanine amidase
M0D43_13645	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
M0D43_13680	COG5383	Protein conserved in bacteria
M0D43_13700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D43_13705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D43_13710	COG1473	amidohydrolase
M0D43_13715	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M0D43_13715	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M0D43_13720	COG1652	LysM domain
M0D43_13745	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
M0D43_13755	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M0D43_13760	COG3118	belongs to the thioredoxin family
M0D43_13770	COG2884	Cell division ATP-binding protein ftsE
M0D43_13775	COG2177	Part of the ABC transporter FtsEX involved in
M0D43_13780	COG2201	protein-glutamate methylesterase activity
M0D43_13785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M0D43_13790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M0D43_13795	COG2860	membrane
M0D43_13800	COG1252	NADH dehydrogenase
M0D43_13815	COG0625	glutathione transferase activity
M0D43_13820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M0D43_13840	COG0534	Mate efflux family protein
M0D43_13845	COG0616	signal peptide processing
M0D43_13855	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_13870	COG0009	L-threonylcarbamoyladenylate synthase
M0D43_13875	COG1754	DNA topoisomerase type I activity
M0D43_13875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M0D43_13895	COG0758	DNA mediated transformation
M0D43_13900	COG1652	LysM domain
M0D43_13905	COG0242	peptide deformylase activity
M0D43_13910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M0D43_13915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M0D43_13915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M0D43_13960	COG1560	Kdo2-lipid A biosynthetic process
M0D43_13965	COG1490	D-aminoacyl-tRNA deacylase activity
M0D43_13970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M0D43_14065	COG1999	signal sequence binding
M0D43_14080	COG0024	Methionine aminopeptidase
M0D43_14090	COG0038	chloride channel
M0D43_14125	COG0251	oxidation-reduction process
M0D43_14140	COG1131	(ABC) transporter
M0D43_14200	COG1063	alcohol dehydrogenase
M0D43_14210	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_14225	COG1294	oxidase, subunit
M0D43_14230	COG1271	oxidase subunit
M0D43_14245	COG3546	catalase activity
M0D43_14250	COG3685	Protein conserved in bacteria
M0D43_14265	COG2972	Histidine kinase
M0D43_14280	COG0531	amino acid
M0D43_14295	COG3590	peptidase
M0D43_14305	COG0667	Aldo Keto reductase
M0D43_14315	COG0583	DNA-binding transcription factor activity
M0D43_14325	COG3384	dioxygenase
M0D43_14335	COG1573	uracil-dna glycosylase
M0D43_14340	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M0D43_14350	COG0025	NhaP-type Na H and K H
M0D43_14355	COG1131	(ABC) transporter
M0D43_14360	COG0842	Transport permease protein
M0D43_14385	COG1404	Belongs to the peptidase S8 family
M0D43_14400	COG0745	RESPONSE REGULATOR receiver
M0D43_14445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D43_14450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M0D43_14470	COG2205	protein histidine kinase activity
M0D43_14470	COG2202	Pas domain
M0D43_14490	COG2813	Specifically methylates the guanine in position
M0D43_14495	COG1187	pseudouridine synthase activity
M0D43_14500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D43_14520	COG3850	Histidine kinase
M0D43_14520	COG3437	response regulator, receiver
M0D43_14520	COG2205	protein histidine kinase activity
M0D43_14520	COG4999	Histidine kinase
M0D43_14535	COG0697	spore germination
M0D43_14540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M0D43_14545	COG2011	ABC-type metal ion transport system permease component
M0D43_14585	COG0508	dehydrogenase complex catalyzes the overall conversion of
M0D43_14595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M0D43_14620	COG0356	it plays a direct role in the translocation of protons across the membrane
M0D43_14630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M0D43_14635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M0D43_14640	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M0D43_14645	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M0D43_14670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M0D43_14690	COG0577	efflux transmembrane transporter activity
M0D43_14690	COG1136	(ABC) transporter
M0D43_14695	COG0577	efflux transmembrane transporter activity
M0D43_14695	COG1136	(ABC) transporter
M0D43_14700	COG0577	efflux transmembrane transporter activity
M0D43_14700	COG1136	(ABC) transporter
M0D43_14705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D43_14710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M0D43_14760	COG0339	signal peptide processing
M0D43_14775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M0D43_14785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M0D43_14800	COG1956	GAF domain-containing protein
M0D43_14805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M0D43_14815	COG0720	synthase
M0D43_14820	COG0513	Belongs to the DEAD box helicase family
M0D43_14830	COG0625	glutathione transferase activity
M0D43_14860	COG0626	cystathionine gamma-synthase activity
M0D43_14875	COG0110	maltose O-acetyltransferase activity
M0D43_14880	COG1216	Glycosyl transferase, family 2
M0D43_14880	COG0438	transferase activity, transferring glycosyl groups
M0D43_14885	COG3754	Rhamnan synthesis protein F
M0D43_14895	COG2226	methyltransferase
M0D43_14915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D43_14930	COG0300	oxidoreductase activity
M0D43_14935	COG0277	FAD linked oxidase domain protein
M0D43_14940	COG0546	phosphoglycolate phosphatase activity
M0D43_14940	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M0D43_14955	COG2086	electron transfer activity
M0D43_14980	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M0D43_14980	COG0662	Cupin 2, conserved barrel domain protein
M0D43_14985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M0D43_15020	COG3218	ABC-type transport auxiliary lipoprotein component
M0D43_15020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M0D43_15025	COG1127	ABC transporter
M0D43_15030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M0D43_15045	COG0442	prolyl-tRNA aminoacylation
M0D43_15055	COG1183	phosphatidylcholine synthase activity
M0D43_15075	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M0D43_15080	COG1012	belongs to the aldehyde dehydrogenase family
M0D43_15085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M0D43_15095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M0D43_15110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M0D43_15120	COG2205	protein histidine kinase activity
M0D43_15145	COG3791	Glutathione-dependent formaldehyde-activating
M0D43_15170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M0D43_15175	COG0697	spore germination
M0D43_15185	COG1307	EDD domain protein, DegV family
M0D43_15220	COG0402	S-adenosylhomocysteine deaminase activity
M0D43_15225	COG3964	amidohydrolase
M0D43_15240	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M0D43_15260	COG0436	Aminotransferase
M0D43_15265	COG1162	GTPase activity
M0D43_15295	COG2211	Major facilitator Superfamily
M0D43_15300	COG1609	Transcriptional regulator
M0D43_15305	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_15310	COG2851	Citrate transporter
M0D43_15325	COG0642	Histidine kinase
M0D43_15335	COG2197	response regulator
M0D43_15355	COG0667	Aldo Keto reductase
M0D43_15360	COG0583	DNA-binding transcription factor activity
M0D43_15375	COG4191	Histidine kinase
M0D43_15390	COG1301	dicarboxylic acid transport
M0D43_15395	COG0280	phosphate acetyltransferase
M0D43_15395	COG0281	malic enzyme
M0D43_15565	COG1560	Kdo2-lipid A biosynthetic process
M0D43_15570	COG1519	Transferase
M0D43_15575	COG1538	Outer membrane efflux protein
M0D43_15580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M0D43_15600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M0D43_15605	COG0066	3-isopropylmalate dehydratase activity
M0D43_15615	COG0473	3-isopropylmalate dehydrogenase activity
M0D43_15620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M0D43_15640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M0D43_15645	COG0405	Gamma-glutamyltransferase
M0D43_15650	COG0840	transmembrane signaling receptor activity
M0D43_15655	COG0823	Involved in the tonB-independent uptake of proteins
M0D43_15655	COG4946	Tricorn protease homolog
M0D43_15655	COG1506	peptidase
M0D43_15660	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M0D43_15665	COG3710	Transcriptional regulator
M0D43_15685	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M0D43_15695	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
M0D43_15755	COG0563	adenylate kinase activity
M0D43_15760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M0D43_15770	COG3781	membrane
M0D43_15775	COG0671	phosphoesterase, PA-phosphatase related
M0D43_15785	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_15800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M0D43_15830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D43_15835	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M0D43_15850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M0D43_15865	COG0352	thiamine-phosphate diphosphorylase activity
M0D43_15870	COG1773	rubredoxin
M0D43_15875	COG2912	Transglutaminase-like superfamily
M0D43_15895	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M0D43_15920	COG0006	proline dipeptidase activity
M0D43_15930	COG0006	proline dipeptidase activity
M0D43_15945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M0D43_15950	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M0D43_15960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M0D43_15965	COG1561	YicC-like family, N-terminal region
M0D43_15985	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_16000	COG1175	transmembrane transport
M0D43_16005	COG3659	wide pore channel activity
M0D43_16015	COG2390	Transcriptional regulator
M0D43_16020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D43_16025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M0D43_16030	COG0583	DNA-binding transcription factor activity
M0D43_16045	COG2271	Major facilitator Superfamily
M0D43_16060	COG2721	sulfolactate sulfo-lyase activity
M0D43_16070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M0D43_16100	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M0D43_16130	COG0714	Associated with various cellular activities
M0D43_16150	COG2304	oxidoreductase activity
M0D43_16160	COG1301	dicarboxylic acid transport
M0D43_16170	COG4773	Receptor
M0D43_16175	COG0583	DNA-binding transcription factor activity
M0D43_16180	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_16185	COG0739	heme binding
M0D43_16190	COG1376	ErfK ybiS ycfS ynhG family protein
M0D43_16225	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_16240	COG0642	Histidine kinase
M0D43_16260	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M0D43_16265	COG4149	molybdate abc transporter
M0D43_16270	COG0725	ABC transporter, periplasmic molybdate-binding protein
M0D43_16275	COG3453	Protein conserved in bacteria
M0D43_16275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M0D43_16285	COG3047	cAMP biosynthetic process
M0D43_16295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M0D43_16325	COG0469	pyruvate kinase activity
M0D43_16330	COG3588	fructose-bisphosphate aldolase
M0D43_16335	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M0D43_16360	COG0583	DNA-binding transcription factor activity
M0D43_16375	COG2205	protein histidine kinase activity
M0D43_16375	COG2198	Histidine kinase
M0D43_16375	COG0784	Response regulator, receiver
M0D43_16395	COG0175	sulfate reduction
M0D43_16400	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M0D43_16405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M0D43_16410	COG0175	sulfate reduction
M0D43_16415	COG0529	Catalyzes the synthesis of activated sulfate
M0D43_16415	COG2895	sulfate adenylyltransferase (ATP) activity
M0D43_16425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D43_16440	COG0308	aminopeptidase N
M0D43_16450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M0D43_16460	COG4948	Mandelate Racemase Muconate Lactonizing
M0D43_16465	COG3250	beta-galactosidase activity
M0D43_16485	COG1609	Transcriptional regulator
M0D43_16495	COG1970	mechanosensitive ion channel activity
M0D43_16515	COG0471	metal ion transport
M0D43_16515	COG3273	potassium ion transport
M0D43_16525	COG2022	thiamine diphosphate biosynthetic process
M0D43_16580	COG0745	RESPONSE REGULATOR receiver
M0D43_16640	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M0D43_16650	COG4969	Belongs to the N-Me-Phe pilin family
M0D43_16655	COG2194	sulfuric ester hydrolase activity
M0D43_16670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M0D43_16690	COG0045	succinate-CoA ligase (ADP-forming) activity
M0D43_16705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M0D43_16705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M0D43_16710	COG0537	adenosine 5'-monophosphoramidase activity
M0D43_16715	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D43_16720	COG0564	pseudouridine synthase activity
M0D43_16735	COG3011	Protein conserved in bacteria
M0D43_16740	COG0840	transmembrane signaling receptor activity
M0D43_16755	COG3387	PFAM Glycoside hydrolase 15-related
M0D43_16760	COG1877	trehalose-phosphatase activity
M0D43_16810	COG0542	response to heat
M0D43_16845	COG4206	TonB-dependent receptor
M0D43_16870	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M0D43_16880	COG1492	cobalamin metabolic process
M0D43_16890	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M0D43_16920	COG0019	diaminopimelate decarboxylase activity
M0D43_16935	COG4264	IucA IucC family
M0D43_16945	COG4772	TonB-dependent receptor
M0D43_16970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M0D43_16970	COG4651	solute:proton antiporter activity
M0D43_17005	COG0488	(ABC) transporter
M0D43_17045	COG0477	Major facilitator Superfamily
M0D43_17060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M0D43_17080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M0D43_17090	COG3158	transport of potassium into the cell
M0D43_17100	COG2255	four-way junction helicase activity
M0D43_17105	COG0824	Thioesterase
M0D43_17125	COG0823	Involved in the tonB-independent uptake of proteins
M0D43_17130	COG2885	chlorophyll binding
M0D43_17140	COG0602	queuosine metabolic process
M0D43_17150	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M0D43_17180	COG0840	transmembrane signaling receptor activity
M0D43_17190	COG1187	pseudouridine synthase activity
M0D43_17210	COG0514	ATP-dependent DNA helicase (RecQ)
M0D43_17215	COG0783	Belongs to the Dps family
M0D43_17220	COG1643	Atp-dependent helicase
M0D43_17260	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
M0D43_17275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M0D43_17285	COG1215	transferase activity, transferring glycosyl groups
M0D43_17290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M0D43_17300	COG1199	ATP-dependent helicase activity
M0D43_17310	COG1397	ADP-ribosylglycohydrolase
M0D43_17320	COG0189	ligase activity
M0D43_17335	COG0835	chemotaxis
M0D43_17340	COG0840	transmembrane signaling receptor activity
M0D43_17345	COG0784	Response regulator, receiver
M0D43_17345	COG0643	Histidine kinase
M0D43_17345	COG2198	Histidine kinase
M0D43_17370	COG1595	DNA-templated transcription, initiation
M0D43_17375	COG2304	oxidoreductase activity
M0D43_17380	COG1446	asparaginase
M0D43_17385	COG3142	Participates in the control of copper homeostasis
M0D43_17420	COG3537	Alpha-1,2-mannosidase
M0D43_17430	COG1486	melibiose metabolic process
M0D43_17435	COG0531	amino acid
M0D43_17450	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D43_17460	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M0D43_17470	COG1388	LysM domain
M0D43_17470	COG3858	chitin binding
M0D43_17485	COG0837	glucose binding
M0D43_17490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M0D43_17500	COG0494	nUDIX hydrolase
M0D43_17510	COG3956	TIGRFAM MazG family protein
M0D43_17515	COG1742	UPF0060 membrane protein
M0D43_17520	COG0330	HflC and HflK could
M0D43_17530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M0D43_17535	COG0509	glycine decarboxylation via glycine cleavage system
M0D43_17560	COG1960	acyl-CoA dehydrogenase activity
M0D43_17570	COG1309	transcriptional regulator
M0D43_17575	COG4771	TonB-dependent receptor
M0D43_17585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M0D43_17590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M0D43_17595	COG0463	Glycosyl transferase, family 2
M0D43_17600	COG0516	GMP reductase activity
M0D43_17600	COG0517	IMP dehydrogenase activity
M0D43_17605	COG2982	Protein involved in outer membrane biogenesis
M0D43_17610	COG1272	protein, Hemolysin III
M0D43_17615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M0D43_17620	COG0739	heme binding
M0D43_17625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D43_17630	COG0626	cystathionine gamma-synthase activity
M0D43_17635	COG0460	homoserine dehydrogenase
M0D43_17635	COG0527	aspartate kinase activity
M0D43_17645	COG1760	l-serine dehydratase
M0D43_17665	COG2353	YceI-like domain
M0D43_17675	COG0784	Response regulator, receiver
M0D43_17675	COG5002	protein histidine kinase activity
M0D43_17680	COG0784	Response regulator, receiver
M0D43_17680	COG2205	protein histidine kinase activity
M0D43_17690	COG0477	Major facilitator Superfamily
M0D43_17695	COG2204	response regulator
M0D43_17765	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M0D43_17780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M0D43_17795	COG1842	Phage shock protein A
M0D43_17820	COG0754	glutathionylspermidine amidase activity
M0D43_17825	COG2814	Major facilitator Superfamily
M0D43_17885	COG0531	amino acid
M0D43_17905	COG1113	amino acid transport
M0D43_17915	COG1271	oxidase subunit
M0D43_17920	COG1294	oxidase, subunit
M0D43_17930	COG2239	Acts as a magnesium transporter
M0D43_17935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M0D43_17940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D43_17950	COG1660	Displays ATPase and GTPase activities
M0D43_17960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D43_17975	COG1137	ATPase activity
M0D43_17990	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M0D43_18000	COG0271	Belongs to the BolA IbaG family
M0D43_18005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M0D43_18025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M0D43_18035	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M0D43_18045	COG0628	permease
M0D43_18060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M0D43_18065	COG3178	'Phosphotransferase
M0D43_18075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D43_18080	COG1555	photosystem II stabilization
M0D43_18095	COG1477	protein flavinylation
M0D43_18120	COG3128	pkhd-type hydroxylase
M0D43_18125	COG4774	siderophore transport
M0D43_18130	COG2146	nitrite reductase [NAD(P)H] activity
M0D43_18140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M0D43_18145	COG0719	Fe-S assembly protein
M0D43_18150	COG0396	ATPase activity
M0D43_18155	COG0719	Fe-S assembly protein
M0D43_18160	COG1959	2 iron, 2 sulfur cluster binding
M0D43_18170	COG0693	protein deglycase activity
M0D43_18190	COG4942	peptidase
M0D43_18210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M0D43_18235	COG0519	Catalyzes the synthesis of GMP from XMP
M0D43_18240	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M0D43_18245	COG1678	Uncharacterized ACR, COG1678
M0D43_18250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M0D43_18255	COG0540	Belongs to the ATCase OTCase family
M0D43_18260	COG1764	response to oxidative stress
M0D43_18270	COG0384	phenazine biosynthesis protein PhzF
M0D43_18280	COG0527	aspartate kinase activity
M0D43_18305	COG0142	geranyltranstransferase activity
M0D43_18310	COG0629	single-stranded DNA binding
M0D43_18355	COG0673	inositol 2-dehydrogenase activity
M0D43_18360	COG2211	Major facilitator Superfamily
M0D43_18370	COG1609	Transcriptional regulator
M0D43_18375	COG2203	Gaf domain
M0D43_18375	COG3706	GGDEF domain
M0D43_18375	COG4251	negative regulation of phosphorylation
M0D43_18375	COG5001	Diguanylate cyclase
M0D43_18385	COG2080	2 iron, 2 sulfur cluster binding
M0D43_18390	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M0D43_18395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M0D43_18400	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M0D43_18435	COG2879	small protein
M0D43_18440	COG1966	Carbon starvation protein
M0D43_18445	COG1741	Belongs to the pirin family
M0D43_18460	COG1741	Belongs to the pirin family
M0D43_18465	COG1515	deoxyribonuclease V activity
M0D43_18470	COG0588	phosphoglycerate mutase activity
M0D43_18480	COG3590	peptidase
M0D43_18485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D43_18495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M0D43_18500	COG2199	diguanylate cyclase activity
M0D43_18500	COG2200	EAL domain
M0D43_18500	COG2202	Pas domain
M0D43_18505	COG0835	chemotaxis
M0D43_18510	COG0840	transmembrane signaling receptor activity
M0D43_18515	COG0643	Histidine kinase
M0D43_18515	COG2198	Histidine kinase
M0D43_18525	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M0D43_18535	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M0D43_18540	COG0745	RESPONSE REGULATOR receiver
M0D43_18550	COG2205	protein histidine kinase activity
M0D43_18560	COG4452	Inner membrane protein CreD
M0D43_18585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D43_18590	COG0735	belongs to the Fur family
M0D43_18605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D43_18615	COG1309	transcriptional regulator
M0D43_18625	COG2207	Transcriptional regulator
M0D43_18640	COG0583	DNA-binding transcription factor activity
M0D43_18645	COG2814	Major facilitator Superfamily
M0D43_18650	COG0667	Aldo Keto reductase
M0D43_18750	COG5001	Diguanylate cyclase
M0D43_18750	COG5002	protein histidine kinase activity
M0D43_18755	COG1187	pseudouridine synthase activity
M0D43_18780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M0D43_18790	COG0475	glutathione-regulated potassium exporter activity
M0D43_18795	COG5002	protein histidine kinase activity
M0D43_18795	COG5000	phosphorelay sensor kinase activity
M0D43_18800	COG0745	RESPONSE REGULATOR receiver
M0D43_18810	COG3713	MltA-interacting MipA family protein
M0D43_18830	COG1132	(ABC) transporter
M0D43_18910	COG3118	belongs to the thioredoxin family
M0D43_18920	COG0495	leucyl-tRNA aminoacylation
M0D43_18935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M0D43_18950	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M0D43_18970	COG2968	Membrane
M0D43_18985	COG3164	Protein of unknown function
M0D43_18995	COG0312	modulator of DNA gyrase
M0D43_19000	COG3028	Belongs to the UPF0307 family
M0D43_19005	COG0312	modulator of DNA gyrase
M0D43_19015	COG4104	PAAR repeat-containing protein
M0D43_19020	COG0142	geranyltranstransferase activity
M0D43_19025	COG1722	exodeoxyribonuclease VII activity
M0D43_19030	COG0037	tRNA processing
M0D43_19035	COG1785	Belongs to the alkaline phosphatase family
M0D43_19040	COG1301	dicarboxylic acid transport
M0D43_19045	COG2226	methyltransferase
M0D43_19060	COG0791	NLP P60 protein
M0D43_19065	COG0791	NLP P60 protein
M0D43_19070	COG1047	Peptidyl-prolyl cis-trans
M0D43_19075	COG2311	Membrane
M0D43_19080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D43_19085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M0D43_19105	COG3590	peptidase
M0D43_19110	COG3590	peptidase
M0D43_19125	COG0489	protein tyrosine kinase activity
M0D43_19130	COG0717	Belongs to the dCTP deaminase family
M0D43_19160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M0D43_19165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D43_19180	COG0494	nUDIX hydrolase
M0D43_19190	COG0433	COG0433 Predicted ATPase
M0D43_19200	COG0688	phosphatidylethanolamine metabolic process
M0D43_19210	COG2890	protein-(glutamine-N5) methyltransferase activity
M0D43_19215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M0D43_19220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M0D43_19225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M0D43_19245	COG0101	tRNA pseudouridine synthase activity
M0D43_19250	COG0135	phosphoribosylanthranilate isomerase activity
M0D43_19265	COG0133	tryptophan synthase activity
M0D43_19280	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M0D43_19285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M0D43_19320	COG0149	triose-phosphate isomerase activity
M0D43_19335	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M0D43_19345	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M0D43_19350	COG0649	NAD binding
M0D43_19355	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M0D43_19365	COG1034	ATP synthesis coupled electron transport
M0D43_19370	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M0D43_19380	COG0839	Belongs to the complex I subunit 6 family
M0D43_19400	COG1007	ATP synthesis coupled electron transport
M0D43_19410	COG0779	Required for maturation of 30S ribosomal subunits
M0D43_19415	COG0195	Participates in both transcription termination and antitermination
M0D43_19425	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M0D43_19435	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M0D43_19440	COG1185	polyribonucleotide nucleotidyltransferase activity
M0D43_19475	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M0D43_19485	COG2095	MarC family integral membrane protein
M0D43_19495	COG1611	Belongs to the LOG family
M0D43_19540	COG0556	nucleotide-excision repair
M0D43_19555	COG3505	Type IV secretory pathway VirD4
M0D43_19575	COG2948	multi-organism process
M0D43_19595	COG3702	type iv secretory pathway
M0D43_19605	COG0366	Alpha amylase catalytic
M0D43_19640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M0D43_19645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M0D43_19660	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M0D43_19665	COG0072	phenylalanine-tRNA ligase activity
M0D43_19665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D43_19720	COG0438	transferase activity, transferring glycosyl groups
M0D43_19730	COG0438	transferase activity, transferring glycosyl groups
M0D43_19755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D43_19765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D43_19785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M0D43_19795	COG1960	acyl-CoA dehydrogenase activity
M0D43_19805	COG3040	lipid binding
M0D43_19825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M0D43_19835	COG4191	Histidine kinase
M0D43_19835	COG0784	Response regulator, receiver
M0D43_19845	COG1194	a g-specific adenine glycosylase
M0D43_19850	COG0552	protein localization to endoplasmic reticulum
M0D43_19860	COG3938	Belongs to the proline racemase family
M0D43_19865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D43_19880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M0D43_19890	COG0006	proline dipeptidase activity
M0D43_19905	COG0531	amino acid
M0D43_19950	COG1506	peptidase
M0D43_19950	COG0823	Involved in the tonB-independent uptake of proteins
M0D43_19970	COG0326	Molecular chaperone. Has ATPase activity
M0D43_19975	COG0742	ribosomal rna small subunit methyltransferase
M0D43_19980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M0D43_19990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M0D43_19995	COG0405	Gamma-glutamyltransferase
M0D43_20005	COG3291	Pkd domain containing protein
M0D43_20010	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M0D43_20035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M0D43_20045	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M0D43_20050	COG0343	queuine tRNA-ribosyltransferase activity
M0D43_20055	COG1862	Preprotein translocase
M0D43_20065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M0D43_20115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M0D43_20115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M0D43_20120	COG1105	Belongs to the carbohydrate kinase PfkB family
M0D43_20125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D43_20125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M0D43_20130	COG1609	Transcriptional regulator
M0D43_20135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D43_20150	COG2902	Dehydrogenase
M0D43_20195	COG0477	Major facilitator Superfamily
M0D43_20205	COG5002	protein histidine kinase activity
M0D43_20205	COG0784	Response regulator, receiver
M0D43_20205	COG2205	protein histidine kinase activity
M0D43_20210	COG2733	membrane
M0D43_20220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M0D43_20230	COG2223	nitrite transmembrane transporter activity
M0D43_20235	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M0D43_20240	COG0243	molybdopterin cofactor binding
M0D43_20250	COG0477	Major facilitator Superfamily
M0D43_20260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D43_20265	COG0174	glutamine synthetase
M0D43_20270	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M0D43_20285	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M0D43_20305	COG3842	ATPase activity
M0D43_20310	COG1176	ABC-type spermidine putrescine transport system, permease component I
M0D43_20315	COG1177	transmembrane transport
M0D43_20325	COG1012	belongs to the aldehyde dehydrogenase family
M0D43_20340	COG4535	Mg2 and Co2 transporter CorC
M0D43_20350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M0D43_20360	COG1702	phosphate starvation-inducible protein PhoH
M0D43_20380	COG0741	lytic transglycosylase activity
M0D43_20385	COG0723	plastoquinol--plastocyanin reductase activity
M0D43_20390	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M0D43_20395	COG2857	Cytochrome c1
M0D43_20400	COG0625	glutathione transferase activity
M0D43_20405	COG2969	positive regulation of protein catabolic process
M0D43_20430	COG1201	RNA secondary structure unwinding
M0D43_20440	COG0835	chemotaxis
M0D43_20485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M0D43_20495	COG1570	exodeoxyribonuclease VII activity
M0D43_20505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M0D43_20505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M0D43_20510	COG0802	atpase or kinase
M0D43_20515	COG0860	N-Acetylmuramoyl-L-alanine amidase
M0D43_20520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M0D43_20540	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_20545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D43_20550	COG0501	Belongs to the peptidase M48B family
M0D43_20560	COG2081	HI0933 family
M0D43_20565	COG4681	YaeQ
M0D43_20570	COG1671	Belongs to the UPF0178 family
M0D43_20580	COG0625	glutathione transferase activity
M0D43_20590	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M0D43_20595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M0D43_20600	COG0513	Belongs to the DEAD box helicase family
M0D43_20605	COG0488	(ABC) transporter
M0D43_20620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M0D43_20625	COG0483	inositol monophosphate 1-phosphatase activity
M0D43_20640	COG5001	Diguanylate cyclase
M0D43_20640	COG3300	MHYT domain
M0D43_20645	COG1509	lysine 2,3-aminomutase activity
M0D43_20660	COG0402	S-adenosylhomocysteine deaminase activity
M0D43_20665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M0D43_20685	COG4677	pectinesterase activity
M0D43_20705	COG4302	ethanolamine ammonia-lyase activity
M0D43_20725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M0D43_20755	COG2166	iron-sulfur cluster assembly
M0D43_20760	COG0215	cysteine-tRNA ligase activity
M0D43_20770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M0D43_20775	COG0137	argininosuccinate synthase activity
M0D43_20780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D43_20785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M0D43_20800	COG0165	Argininosuccinate lyase
M0D43_20865	COG1294	oxidase, subunit
M0D43_20875	COG4988	ABC transporter
M0D43_20880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M0D43_20890	COG1278	Cold shock
M0D43_20895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D43_20920	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M0D43_20940	COG4133	protoheme IX ABC transporter activity
M0D43_20945	COG0436	Aminotransferase
M0D43_20965	COG1187	pseudouridine synthase activity
M0D43_20970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M0D43_20975	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M0D43_20980	COG2350	Protein conserved in bacteria
M0D43_21010	COG1175	transmembrane transport
M0D43_21015	COG0395	ABC-type sugar transport system, permease component
M0D43_21040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M0D43_21045	COG2957	Belongs to the agmatine deiminase family
M0D43_21060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M0D43_21065	COG0539	negative regulation of cytoplasmic translation
M0D43_21070	COG0776	regulation of translation
M0D43_21080	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M0D43_21085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M0D43_21095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M0D43_21100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M0D43_21100	COG0475	glutathione-regulated potassium exporter activity
M0D43_21110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M0D43_21130	COG3002	Belongs to the UPF0753 family
M0D43_21135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M0D43_21140	COG0583	DNA-binding transcription factor activity
M0D43_21145	COG0583	DNA-binding transcription factor activity
M0D43_21150	COG0583	DNA-binding transcription factor activity
M0D43_21170	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_21190	COG2197	response regulator
M0D43_21205	COG1335	isochorismatase
M0D43_21220	COG2814	Major facilitator Superfamily
M0D43_21235	COG1914	H( )-stimulated, divalent metal cation uptake system
M0D43_21245	COG0590	tRNA wobble adenosine to inosine editing
M0D43_21255	COG0668	transmembrane transport
M0D43_21265	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M0D43_21280	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_21285	COG1183	phosphatidylcholine synthase activity
M0D43_21295	COG3243	poly(R)-hydroxyalkanoic acid synthase
M0D43_21310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D43_21310	COG0723	plastoquinol--plastocyanin reductase activity
M0D43_21320	COG2183	response to ionizing radiation
M0D43_21325	COG0784	Response regulator, receiver
M0D43_21325	COG2205	protein histidine kinase activity
M0D43_21325	COG5002	protein histidine kinase activity
M0D43_21390	COG0800	Aldolase
M0D43_21395	COG0129	dihydroxy-acid dehydratase activity
M0D43_21400	COG0363	glucosamine-6-phosphate deaminase activity
M0D43_21405	COG0837	glucose binding
M0D43_21410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M0D43_21435	COG2009	succinate dehydrogenase
M0D43_21440	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M0D43_21455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M0D43_21460	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M0D43_21470	COG4591	ABC-type transport system involved in lipoprotein release permease component
M0D43_21490	COG0811	peptide transport
M0D43_21500	COG1132	(ABC) transporter
M0D43_21505	COG1663	tetraacyldisaccharide 4'-kinase activity
M0D43_21510	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M0D43_21515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M0D43_21525	COG0322	excinuclease ABC activity
M0D43_21575	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M0D43_21595	COG1054	Belongs to the UPF0176 family
M0D43_21605	COG1530	ribonuclease E activity
M0D43_21610	COG0564	pseudouridine synthase activity
M0D43_21615	COG3064	Membrane
M0D43_21620	COG0428	transporter
M0D43_21630	COG2154	pterin-4-alpha-carbinolamine dehydratase
M0D43_21735	COG0631	protein serine/threonine phosphatase activity
M0D43_21740	COG0515	serine threonine protein kinase
M0D43_21765	COG1858	cytochrome C peroxidase
M0D43_21790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D43_21795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D43_21820	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M0D43_21825	COG1028	Short-chain dehydrogenase reductase Sdr
M0D43_21835	COG0653	protein targeting
M0D43_21850	COG0653	protein targeting
M0D43_21865	COG0653	protein targeting
M0D43_21880	COG0653	protein targeting
M0D43_21900	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D43_21905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D43_21910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D43_21925	COG1024	Enoyl-CoA hydratase
M0D43_21935	COG1024	Enoyl-CoA hydratase
M0D43_21940	COG1024	Enoyl-CoA hydratase
M0D43_21945	COG3424	synthase