locus-tag	class	description
M0D48_00030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M0D48_00040	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M0D48_00050	COG1435	thymidine kinase activity
M0D48_00055	COG0210	DNA helicase
M0D48_00070	COG3132	Protein of unknown function, DUF480
M0D48_00075	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M0D48_00080	COG0284	orotidine-5'-phosphate decarboxylase activity
M0D48_00110	COG2937	Belongs to the GPAT DAPAT family
M0D48_00165	COG2211	Major facilitator Superfamily
M0D48_00180	COG3693	PFAM glycoside hydrolase, family 10
M0D48_00200	COG1904	glucuronate isomerase
M0D48_00205	COG3250	beta-galactosidase activity
M0D48_00220	COG3386	PFAM SMP-30 Gluconolaconase
M0D48_00245	COG0246	Mannitol dehydrogenase
M0D48_00250	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D48_00260	COG4948	Mandelate Racemase Muconate Lactonizing
M0D48_00270	COG3661	Belongs to the glycosyl hydrolase 67 family
M0D48_00290	COG2974	May be involved in recombination
M0D48_00305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M0D48_00315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M0D48_00320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M0D48_00325	COG0805	protein transport
M0D48_00335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M0D48_00335	COG0519	Catalyzes the synthesis of GMP from XMP
M0D48_00345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M0D48_00350	COG0752	glycyl-tRNA synthetase alpha subunit
M0D48_00360	COG0457	Tetratricopeptide repeat
M0D48_00365	COG4771	TonB-dependent receptor
M0D48_00370	COG0729	surface antigen
M0D48_00375	COG2911	Protein conserved in bacteria
M0D48_00395	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D48_00400	COG3265	gluconokinase activity
M0D48_00405	COG2211	Major facilitator Superfamily
M0D48_00410	COG3459	Glycosyltransferase 36 associated
M0D48_00420	COG2205	protein histidine kinase activity
M0D48_00440	COG1414	Transcriptional regulator
M0D48_00445	COG0738	Major facilitator superfamily
M0D48_00450	COG3254	rhamnose metabolic process
M0D48_00455	COG4948	Mandelate Racemase Muconate Lactonizing
M0D48_00460	COG0179	Fumarylacetoacetate (FAA) hydrolase
M0D48_00465	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_00515	COG3162	membrane
M0D48_00520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M0D48_00525	COG1940	carbohydrate kinase activity
M0D48_00545	COG2091	lysine biosynthetic process via aminoadipic acid
M0D48_00555	COG3540	Alkaline phosphatase
M0D48_00560	COG0357	Ribosomal RNA small subunit methyltransferase G
M0D48_00580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_00605	COG2159	amidohydrolase
M0D48_00615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M0D48_00620	COG0583	DNA-binding transcription factor activity
M0D48_00625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D48_00640	COG0210	DNA helicase
M0D48_00730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M0D48_00730	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M0D48_00740	COG0408	coproporphyrinogen oxidase activity
M0D48_00755	COG0823	Involved in the tonB-independent uptake of proteins
M0D48_00755	COG1506	peptidase
M0D48_00755	COG4946	Tricorn protease homolog
M0D48_00770	COG0644	oxidoreductase
M0D48_00775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M0D48_00815	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_00835	COG0463	Glycosyl transferase, family 2
M0D48_00845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M0D48_00850	COG3100	YcgL domain-containing protein
M0D48_00865	COG3387	PFAM Glycoside hydrolase 15-related
M0D48_00870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M0D48_00900	COG2239	Acts as a magnesium transporter
M0D48_00910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M0D48_00910	COG0045	succinate-CoA ligase (ADP-forming) activity
M0D48_00910	COG1042	CoA-binding domain protein
M0D48_00920	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M0D48_00925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M0D48_00955	COG1607	acyl-coa hydrolase
M0D48_00970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M0D48_00975	COG0842	Transport permease protein
M0D48_00980	COG1131	(ABC) transporter
M0D48_00985	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M0D48_01005	COG1476	TRANSCRIPTIONal
M0D48_01015	COG4555	ABC transporter
M0D48_01050	COG0625	glutathione transferase activity
M0D48_01145	COG1199	ATP-dependent helicase activity
M0D48_01180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M0D48_01225	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M0D48_01240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M0D48_01280	COG3237	CsbD-like
M0D48_01285	COG0180	Tryptophanyl-tRNA synthetase
M0D48_01310	COG0697	spore germination
M0D48_01335	COG1136	(ABC) transporter
M0D48_01340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_01345	COG4585	Histidine kinase
M0D48_01350	COG2197	response regulator
M0D48_01365	COG0753	catalase activity
M0D48_01370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M0D48_01375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D48_01380	COG0628	permease
M0D48_01400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M0D48_01410	COG1090	epimerase
M0D48_01445	COG1690	Belongs to the RtcB family
M0D48_01475	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M0D48_01490	COG0606	chelatase, subunit chli
M0D48_01505	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M0D48_01505	COG3291	Pkd domain containing protein
M0D48_01525	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M0D48_01530	COG1166	arginine decarboxylase activity
M0D48_01540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M0D48_01550	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M0D48_01550	COG2755	lipolytic protein G-D-S-L family
M0D48_01555	COG4221	oxidoreductase activity
M0D48_01570	COG0018	arginyl-trna synthetase
M0D48_01575	COG2003	Belongs to the UPF0758 family
M0D48_01580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M0D48_01605	COG0463	Glycosyl transferase, family 2
M0D48_01620	COG1475	DNA binding
M0D48_01625	COG1192	Involved in chromosome partitioning
M0D48_01640	COG0708	Exodeoxyribonuclease III
M0D48_01645	COG2223	nitrite transmembrane transporter activity
M0D48_01660	COG0739	heme binding
M0D48_01705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M0D48_01720	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M0D48_01770	COG0358	DNA primase activity
M0D48_01775	COG1295	ribonuclease BN
M0D48_01785	COG1610	YqeY-like protein
M0D48_01795	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M0D48_01800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M0D48_01810	COG2133	pyrroloquinoline quinone binding
M0D48_01815	COG4682	membrane
M0D48_01830	COG0531	amino acid
M0D48_01840	COG4948	Mandelate Racemase Muconate Lactonizing
M0D48_01850	COG3023	N-Acetylmuramoyl-L-alanine amidase
M0D48_01855	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
M0D48_01890	COG5383	Protein conserved in bacteria
M0D48_01915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D48_01920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_01925	COG1473	amidohydrolase
M0D48_01930	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M0D48_01930	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M0D48_01935	COG1652	LysM domain
M0D48_01960	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
M0D48_01970	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M0D48_01975	COG3118	belongs to the thioredoxin family
M0D48_01985	COG2884	Cell division ATP-binding protein ftsE
M0D48_01990	COG2177	Part of the ABC transporter FtsEX involved in
M0D48_01995	COG2201	protein-glutamate methylesterase activity
M0D48_02000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M0D48_02005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M0D48_02010	COG2860	membrane
M0D48_02015	COG1252	NADH dehydrogenase
M0D48_02030	COG0625	glutathione transferase activity
M0D48_02035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M0D48_02055	COG0534	Mate efflux family protein
M0D48_02060	COG0616	signal peptide processing
M0D48_02070	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_02085	COG0009	L-threonylcarbamoyladenylate synthase
M0D48_02090	COG1754	DNA topoisomerase type I activity
M0D48_02090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M0D48_02110	COG0758	DNA mediated transformation
M0D48_02115	COG1652	LysM domain
M0D48_02120	COG0242	peptide deformylase activity
M0D48_02125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M0D48_02130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M0D48_02130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M0D48_02175	COG1560	Kdo2-lipid A biosynthetic process
M0D48_02180	COG1490	D-aminoacyl-tRNA deacylase activity
M0D48_02185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M0D48_02200	COG0582	viral genome integration into host DNA
M0D48_02385	COG1999	signal sequence binding
M0D48_02400	COG0024	Methionine aminopeptidase
M0D48_02410	COG0038	chloride channel
M0D48_02445	COG0251	oxidation-reduction process
M0D48_02460	COG1131	(ABC) transporter
M0D48_02520	COG1063	alcohol dehydrogenase
M0D48_02530	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_02545	COG1294	oxidase, subunit
M0D48_02550	COG1271	oxidase subunit
M0D48_02565	COG3546	catalase activity
M0D48_02570	COG3685	Protein conserved in bacteria
M0D48_02585	COG2972	Histidine kinase
M0D48_02600	COG0531	amino acid
M0D48_02615	COG3590	peptidase
M0D48_02625	COG0667	Aldo Keto reductase
M0D48_02635	COG0583	DNA-binding transcription factor activity
M0D48_02645	COG3384	dioxygenase
M0D48_02655	COG1573	uracil-dna glycosylase
M0D48_02660	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M0D48_02670	COG0025	NhaP-type Na H and K H
M0D48_02675	COG1131	(ABC) transporter
M0D48_02680	COG0842	Transport permease protein
M0D48_02715	COG3227	Zinc metalloprotease (Elastase)
M0D48_02735	COG0745	RESPONSE REGULATOR receiver
M0D48_02780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D48_02785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M0D48_02805	COG2205	protein histidine kinase activity
M0D48_02805	COG2202	Pas domain
M0D48_02825	COG2813	Specifically methylates the guanine in position
M0D48_02830	COG1187	pseudouridine synthase activity
M0D48_02835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D48_02855	COG3850	Histidine kinase
M0D48_02855	COG2205	protein histidine kinase activity
M0D48_02855	COG3437	response regulator, receiver
M0D48_02855	COG4999	Histidine kinase
M0D48_02870	COG0697	spore germination
M0D48_02875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M0D48_02880	COG2011	ABC-type metal ion transport system permease component
M0D48_02920	COG0508	dehydrogenase complex catalyzes the overall conversion of
M0D48_02930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M0D48_02955	COG0356	it plays a direct role in the translocation of protons across the membrane
M0D48_02965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M0D48_02970	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M0D48_02975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M0D48_02980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M0D48_03005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M0D48_03025	COG1136	(ABC) transporter
M0D48_03025	COG0577	efflux transmembrane transporter activity
M0D48_03030	COG0577	efflux transmembrane transporter activity
M0D48_03030	COG1136	(ABC) transporter
M0D48_03035	COG1136	(ABC) transporter
M0D48_03035	COG0577	efflux transmembrane transporter activity
M0D48_03040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_03045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M0D48_03110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M0D48_03120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M0D48_03135	COG1956	GAF domain-containing protein
M0D48_03140	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M0D48_03150	COG0720	synthase
M0D48_03155	COG0513	Belongs to the DEAD box helicase family
M0D48_03165	COG0625	glutathione transferase activity
M0D48_03195	COG0626	cystathionine gamma-synthase activity
M0D48_03210	COG0110	maltose O-acetyltransferase activity
M0D48_03215	COG0438	transferase activity, transferring glycosyl groups
M0D48_03215	COG1216	Glycosyl transferase, family 2
M0D48_03220	COG3754	Rhamnan synthesis protein F
M0D48_03230	COG2226	methyltransferase
M0D48_03250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D48_03260	COG0300	oxidoreductase activity
M0D48_03265	COG0277	FAD linked oxidase domain protein
M0D48_03270	COG0546	phosphoglycolate phosphatase activity
M0D48_03270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M0D48_03285	COG2086	electron transfer activity
M0D48_03310	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M0D48_03310	COG0662	Cupin 2, conserved barrel domain protein
M0D48_03315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M0D48_03350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M0D48_03350	COG3218	ABC-type transport auxiliary lipoprotein component
M0D48_03355	COG1127	ABC transporter
M0D48_03360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M0D48_03375	COG0442	prolyl-tRNA aminoacylation
M0D48_03385	COG1183	phosphatidylcholine synthase activity
M0D48_03405	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M0D48_03410	COG1012	belongs to the aldehyde dehydrogenase family
M0D48_03415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M0D48_03425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M0D48_03440	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M0D48_03450	COG2205	protein histidine kinase activity
M0D48_03475	COG3791	Glutathione-dependent formaldehyde-activating
M0D48_03500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M0D48_03505	COG0697	spore germination
M0D48_03515	COG1307	EDD domain protein, DegV family
M0D48_03550	COG0402	S-adenosylhomocysteine deaminase activity
M0D48_03555	COG3964	amidohydrolase
M0D48_03570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M0D48_03590	COG0436	Aminotransferase
M0D48_03595	COG1162	GTPase activity
M0D48_03625	COG2211	Major facilitator Superfamily
M0D48_03630	COG1609	Transcriptional regulator
M0D48_03635	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_03640	COG2851	Citrate transporter
M0D48_03655	COG0642	Histidine kinase
M0D48_03665	COG2197	response regulator
M0D48_03685	COG0667	Aldo Keto reductase
M0D48_03690	COG0583	DNA-binding transcription factor activity
M0D48_03705	COG4191	Histidine kinase
M0D48_03720	COG1301	dicarboxylic acid transport
M0D48_03725	COG0280	phosphate acetyltransferase
M0D48_03725	COG0281	malic enzyme
M0D48_03900	COG1560	Kdo2-lipid A biosynthetic process
M0D48_03905	COG1519	Transferase
M0D48_03910	COG1538	Outer membrane efflux protein
M0D48_03915	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M0D48_03935	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M0D48_03940	COG0066	3-isopropylmalate dehydratase activity
M0D48_03950	COG0473	3-isopropylmalate dehydrogenase activity
M0D48_03955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M0D48_03975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M0D48_03980	COG0405	Gamma-glutamyltransferase
M0D48_03985	COG0840	transmembrane signaling receptor activity
M0D48_03990	COG1506	peptidase
M0D48_03990	COG4946	Tricorn protease homolog
M0D48_03990	COG0823	Involved in the tonB-independent uptake of proteins
M0D48_03995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M0D48_04000	COG3710	Transcriptional regulator
M0D48_04020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M0D48_04030	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
M0D48_04090	COG0563	adenylate kinase activity
M0D48_04095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M0D48_04105	COG3781	membrane
M0D48_04110	COG0671	phosphoesterase, PA-phosphatase related
M0D48_04120	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_04135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M0D48_04165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D48_04170	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M0D48_04185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M0D48_04200	COG0352	thiamine-phosphate diphosphorylase activity
M0D48_04205	COG1773	rubredoxin
M0D48_04210	COG2912	Transglutaminase-like superfamily
M0D48_04230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M0D48_04255	COG0006	proline dipeptidase activity
M0D48_04265	COG0006	proline dipeptidase activity
M0D48_04280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M0D48_04285	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M0D48_04295	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M0D48_04300	COG1561	YicC-like family, N-terminal region
M0D48_04320	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_04335	COG1175	transmembrane transport
M0D48_04340	COG3659	wide pore channel activity
M0D48_04350	COG2390	Transcriptional regulator
M0D48_04355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D48_04360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M0D48_04365	COG0583	DNA-binding transcription factor activity
M0D48_04380	COG2271	Major facilitator Superfamily
M0D48_04395	COG2721	sulfolactate sulfo-lyase activity
M0D48_04405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M0D48_04435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M0D48_04465	COG0714	Associated with various cellular activities
M0D48_04485	COG2304	oxidoreductase activity
M0D48_04495	COG1301	dicarboxylic acid transport
M0D48_04505	COG4773	Receptor
M0D48_04510	COG0583	DNA-binding transcription factor activity
M0D48_04515	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_04520	COG0739	heme binding
M0D48_04525	COG1376	ErfK ybiS ycfS ynhG family protein
M0D48_04560	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_04575	COG0642	Histidine kinase
M0D48_04595	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M0D48_04600	COG4149	molybdate abc transporter
M0D48_04605	COG0725	ABC transporter, periplasmic molybdate-binding protein
M0D48_04610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M0D48_04610	COG3453	Protein conserved in bacteria
M0D48_04620	COG3047	cAMP biosynthetic process
M0D48_04630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M0D48_04660	COG0469	pyruvate kinase activity
M0D48_04665	COG3588	fructose-bisphosphate aldolase
M0D48_04670	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M0D48_04695	COG0583	DNA-binding transcription factor activity
M0D48_04705	COG0784	Response regulator, receiver
M0D48_04705	COG2205	protein histidine kinase activity
M0D48_04705	COG2198	Histidine kinase
M0D48_04725	COG0175	sulfate reduction
M0D48_04730	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M0D48_04735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M0D48_04740	COG0175	sulfate reduction
M0D48_04745	COG2895	sulfate adenylyltransferase (ATP) activity
M0D48_04745	COG0529	Catalyzes the synthesis of activated sulfate
M0D48_04755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D48_04770	COG0308	aminopeptidase N
M0D48_04780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M0D48_04790	COG4948	Mandelate Racemase Muconate Lactonizing
M0D48_04795	COG3250	beta-galactosidase activity
M0D48_04815	COG1609	Transcriptional regulator
M0D48_04825	COG1970	mechanosensitive ion channel activity
M0D48_04845	COG0471	metal ion transport
M0D48_04845	COG3273	potassium ion transport
M0D48_04855	COG2022	thiamine diphosphate biosynthetic process
M0D48_04910	COG0745	RESPONSE REGULATOR receiver
M0D48_04970	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M0D48_04980	COG4969	Belongs to the N-Me-Phe pilin family
M0D48_04985	COG2194	sulfuric ester hydrolase activity
M0D48_05020	COG0045	succinate-CoA ligase (ADP-forming) activity
M0D48_05035	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M0D48_05035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M0D48_05040	COG0537	adenosine 5'-monophosphoramidase activity
M0D48_05045	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D48_05050	COG0564	pseudouridine synthase activity
M0D48_05065	COG3011	Protein conserved in bacteria
M0D48_05070	COG0840	transmembrane signaling receptor activity
M0D48_05085	COG3387	PFAM Glycoside hydrolase 15-related
M0D48_05090	COG1877	trehalose-phosphatase activity
M0D48_05140	COG0542	response to heat
M0D48_05150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_05175	COG4206	TonB-dependent receptor
M0D48_05200	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M0D48_05210	COG1492	cobalamin metabolic process
M0D48_05220	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M0D48_05250	COG0019	diaminopimelate decarboxylase activity
M0D48_05265	COG4264	IucA IucC family
M0D48_05275	COG4772	TonB-dependent receptor
M0D48_05300	COG4651	solute:proton antiporter activity
M0D48_05300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M0D48_05335	COG0488	(ABC) transporter
M0D48_05375	COG0477	Major facilitator Superfamily
M0D48_05390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M0D48_05410	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M0D48_05420	COG3158	transport of potassium into the cell
M0D48_05430	COG2255	four-way junction helicase activity
M0D48_05435	COG0824	Thioesterase
M0D48_05455	COG0823	Involved in the tonB-independent uptake of proteins
M0D48_05460	COG2885	chlorophyll binding
M0D48_05470	COG0602	queuosine metabolic process
M0D48_05480	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M0D48_05510	COG0840	transmembrane signaling receptor activity
M0D48_05520	COG1187	pseudouridine synthase activity
M0D48_05540	COG0514	ATP-dependent DNA helicase (RecQ)
M0D48_05545	COG0783	Belongs to the Dps family
M0D48_05550	COG1643	Atp-dependent helicase
M0D48_05590	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
M0D48_05605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M0D48_05615	COG1215	transferase activity, transferring glycosyl groups
M0D48_05620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M0D48_05630	COG1199	ATP-dependent helicase activity
M0D48_05640	COG1397	ADP-ribosylglycohydrolase
M0D48_05650	COG0189	ligase activity
M0D48_05665	COG0835	chemotaxis
M0D48_05670	COG0840	transmembrane signaling receptor activity
M0D48_05675	COG2198	Histidine kinase
M0D48_05675	COG0643	Histidine kinase
M0D48_05675	COG0784	Response regulator, receiver
M0D48_05700	COG1595	DNA-templated transcription, initiation
M0D48_05705	COG2304	oxidoreductase activity
M0D48_05710	COG1446	asparaginase
M0D48_05715	COG3142	Participates in the control of copper homeostasis
M0D48_05750	COG3537	Alpha-1,2-mannosidase
M0D48_05760	COG1486	melibiose metabolic process
M0D48_05770	COG0531	amino acid
M0D48_05785	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D48_05795	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M0D48_05805	COG1388	LysM domain
M0D48_05805	COG3858	chitin binding
M0D48_05820	COG0837	glucose binding
M0D48_05825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M0D48_05835	COG0494	nUDIX hydrolase
M0D48_05845	COG3956	TIGRFAM MazG family protein
M0D48_05850	COG1742	UPF0060 membrane protein
M0D48_05855	COG0330	HflC and HflK could
M0D48_05865	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M0D48_05870	COG0509	glycine decarboxylation via glycine cleavage system
M0D48_05895	COG1960	acyl-CoA dehydrogenase activity
M0D48_05905	COG1309	transcriptional regulator
M0D48_05910	COG4771	TonB-dependent receptor
M0D48_05920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M0D48_05925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M0D48_05930	COG0463	Glycosyl transferase, family 2
M0D48_05935	COG0516	GMP reductase activity
M0D48_05935	COG0517	IMP dehydrogenase activity
M0D48_05940	COG2982	Protein involved in outer membrane biogenesis
M0D48_05945	COG1272	protein, Hemolysin III
M0D48_05950	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M0D48_05955	COG0739	heme binding
M0D48_05960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D48_05965	COG0626	cystathionine gamma-synthase activity
M0D48_05970	COG0460	homoserine dehydrogenase
M0D48_05970	COG0527	aspartate kinase activity
M0D48_05980	COG1760	l-serine dehydratase
M0D48_06000	COG2353	YceI-like domain
M0D48_06010	COG0784	Response regulator, receiver
M0D48_06010	COG5002	protein histidine kinase activity
M0D48_06015	COG2205	protein histidine kinase activity
M0D48_06015	COG0784	Response regulator, receiver
M0D48_06025	COG2814	Major facilitator Superfamily
M0D48_06030	COG2204	response regulator
M0D48_06100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M0D48_06115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M0D48_06130	COG1842	Phage shock protein A
M0D48_06155	COG0754	glutathionylspermidine amidase activity
M0D48_06160	COG2814	Major facilitator Superfamily
M0D48_06220	COG0531	amino acid
M0D48_06240	COG1113	amino acid transport
M0D48_06250	COG1271	oxidase subunit
M0D48_06255	COG1294	oxidase, subunit
M0D48_06265	COG2239	Acts as a magnesium transporter
M0D48_06270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M0D48_06275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D48_06285	COG1660	Displays ATPase and GTPase activities
M0D48_06295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D48_06310	COG1137	ATPase activity
M0D48_06325	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M0D48_06335	COG0271	Belongs to the BolA IbaG family
M0D48_06340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M0D48_06360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M0D48_06370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M0D48_06380	COG0628	permease
M0D48_06395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M0D48_06400	COG3178	'Phosphotransferase
M0D48_06410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D48_06415	COG1555	photosystem II stabilization
M0D48_06430	COG1477	protein flavinylation
M0D48_06455	COG3128	pkhd-type hydroxylase
M0D48_06460	COG4774	siderophore transport
M0D48_06465	COG2146	nitrite reductase [NAD(P)H] activity
M0D48_06475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M0D48_06480	COG0719	Fe-S assembly protein
M0D48_06485	COG0396	ATPase activity
M0D48_06490	COG0719	Fe-S assembly protein
M0D48_06495	COG1959	2 iron, 2 sulfur cluster binding
M0D48_06505	COG0693	protein deglycase activity
M0D48_06525	COG4942	peptidase
M0D48_06545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M0D48_06570	COG0519	Catalyzes the synthesis of GMP from XMP
M0D48_06575	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M0D48_06580	COG1678	Uncharacterized ACR, COG1678
M0D48_06585	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M0D48_06590	COG0540	Belongs to the ATCase OTCase family
M0D48_06595	COG1764	response to oxidative stress
M0D48_06605	COG0384	phenazine biosynthesis protein PhzF
M0D48_06615	COG0527	aspartate kinase activity
M0D48_06640	COG0142	geranyltranstransferase activity
M0D48_06645	COG0629	single-stranded DNA binding
M0D48_06690	COG0673	inositol 2-dehydrogenase activity
M0D48_06695	COG2211	Major facilitator Superfamily
M0D48_06705	COG1609	Transcriptional regulator
M0D48_06710	COG2203	Gaf domain
M0D48_06710	COG4251	negative regulation of phosphorylation
M0D48_06710	COG5001	Diguanylate cyclase
M0D48_06710	COG3706	GGDEF domain
M0D48_06720	COG2080	2 iron, 2 sulfur cluster binding
M0D48_06725	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M0D48_06730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M0D48_06735	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M0D48_06770	COG2879	small protein
M0D48_06775	COG1966	Carbon starvation protein
M0D48_06780	COG1741	Belongs to the pirin family
M0D48_06795	COG1741	Belongs to the pirin family
M0D48_06800	COG1515	deoxyribonuclease V activity
M0D48_06805	COG0588	phosphoglycerate mutase activity
M0D48_06815	COG3590	peptidase
M0D48_06820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D48_06830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M0D48_06835	COG2202	Pas domain
M0D48_06835	COG2199	diguanylate cyclase activity
M0D48_06835	COG2200	EAL domain
M0D48_06840	COG0835	chemotaxis
M0D48_06845	COG0840	transmembrane signaling receptor activity
M0D48_06850	COG0643	Histidine kinase
M0D48_06850	COG2198	Histidine kinase
M0D48_06860	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M0D48_06870	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M0D48_06875	COG0745	RESPONSE REGULATOR receiver
M0D48_06885	COG2205	protein histidine kinase activity
M0D48_06895	COG4452	Inner membrane protein CreD
M0D48_06920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D48_06925	COG0735	belongs to the Fur family
M0D48_06940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D48_06950	COG1309	transcriptional regulator
M0D48_06960	COG2207	Transcriptional regulator
M0D48_06975	COG0583	DNA-binding transcription factor activity
M0D48_06980	COG2814	Major facilitator Superfamily
M0D48_06985	COG0667	Aldo Keto reductase
M0D48_07085	COG5002	protein histidine kinase activity
M0D48_07085	COG5001	Diguanylate cyclase
M0D48_07090	COG1187	pseudouridine synthase activity
M0D48_07115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M0D48_07125	COG0475	glutathione-regulated potassium exporter activity
M0D48_07130	COG5000	phosphorelay sensor kinase activity
M0D48_07130	COG5002	protein histidine kinase activity
M0D48_07135	COG0745	RESPONSE REGULATOR receiver
M0D48_07145	COG3713	MltA-interacting MipA family protein
M0D48_07165	COG1132	(ABC) transporter
M0D48_07250	COG3118	belongs to the thioredoxin family
M0D48_07260	COG0495	leucyl-tRNA aminoacylation
M0D48_07275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M0D48_07290	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M0D48_07310	COG2968	Membrane
M0D48_07325	COG3164	Protein of unknown function
M0D48_07335	COG0312	modulator of DNA gyrase
M0D48_07340	COG3028	Belongs to the UPF0307 family
M0D48_07345	COG0312	modulator of DNA gyrase
M0D48_07355	COG4104	PAAR repeat-containing protein
M0D48_07360	COG0142	geranyltranstransferase activity
M0D48_07365	COG1722	exodeoxyribonuclease VII activity
M0D48_07370	COG0037	tRNA processing
M0D48_07375	COG1785	Belongs to the alkaline phosphatase family
M0D48_07380	COG1301	dicarboxylic acid transport
M0D48_07385	COG2226	methyltransferase
M0D48_07400	COG0791	NLP P60 protein
M0D48_07405	COG0791	NLP P60 protein
M0D48_07410	COG1047	Peptidyl-prolyl cis-trans
M0D48_07415	COG2311	Membrane
M0D48_07420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D48_07425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M0D48_07445	COG3590	peptidase
M0D48_07450	COG3590	peptidase
M0D48_07470	COG0489	protein tyrosine kinase activity
M0D48_07475	COG0717	Belongs to the dCTP deaminase family
M0D48_07505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M0D48_07510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D48_07525	COG0494	nUDIX hydrolase
M0D48_07535	COG0433	COG0433 Predicted ATPase
M0D48_07545	COG0688	phosphatidylethanolamine metabolic process
M0D48_07555	COG2890	protein-(glutamine-N5) methyltransferase activity
M0D48_07560	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M0D48_07565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M0D48_07570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M0D48_07590	COG0101	tRNA pseudouridine synthase activity
M0D48_07595	COG0135	phosphoribosylanthranilate isomerase activity
M0D48_07610	COG0133	tryptophan synthase activity
M0D48_07625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M0D48_07630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M0D48_07665	COG0149	triose-phosphate isomerase activity
M0D48_07680	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M0D48_07690	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M0D48_07695	COG0649	NAD binding
M0D48_07700	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M0D48_07710	COG1034	ATP synthesis coupled electron transport
M0D48_07715	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M0D48_07725	COG0839	Belongs to the complex I subunit 6 family
M0D48_07745	COG1007	ATP synthesis coupled electron transport
M0D48_07755	COG0779	Required for maturation of 30S ribosomal subunits
M0D48_07760	COG0195	Participates in both transcription termination and antitermination
M0D48_07770	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M0D48_07780	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M0D48_07785	COG1185	polyribonucleotide nucleotidyltransferase activity
M0D48_07820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M0D48_07830	COG2095	MarC family integral membrane protein
M0D48_07840	COG1611	Belongs to the LOG family
M0D48_07885	COG0556	nucleotide-excision repair
M0D48_07900	COG3505	Type IV secretory pathway VirD4
M0D48_07920	COG2948	multi-organism process
M0D48_07940	COG3702	type iv secretory pathway
M0D48_07950	COG0366	Alpha amylase catalytic
M0D48_07985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M0D48_07990	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M0D48_08005	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M0D48_08010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D48_08010	COG0072	phenylalanine-tRNA ligase activity
M0D48_08065	COG0438	transferase activity, transferring glycosyl groups
M0D48_08070	COG0438	transferase activity, transferring glycosyl groups
M0D48_08080	COG0438	transferase activity, transferring glycosyl groups
M0D48_08105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D48_08115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D48_08135	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M0D48_08145	COG1960	acyl-CoA dehydrogenase activity
M0D48_08155	COG3040	lipid binding
M0D48_08175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M0D48_08185	COG0784	Response regulator, receiver
M0D48_08185	COG4191	Histidine kinase
M0D48_08195	COG1194	a g-specific adenine glycosylase
M0D48_08200	COG0552	protein localization to endoplasmic reticulum
M0D48_08210	COG3938	Belongs to the proline racemase family
M0D48_08215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D48_08230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M0D48_08240	COG0006	proline dipeptidase activity
M0D48_08255	COG0531	amino acid
M0D48_08300	COG1506	peptidase
M0D48_08300	COG0823	Involved in the tonB-independent uptake of proteins
M0D48_08320	COG0326	Molecular chaperone. Has ATPase activity
M0D48_08325	COG0742	ribosomal rna small subunit methyltransferase
M0D48_08330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M0D48_08340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M0D48_08345	COG0405	Gamma-glutamyltransferase
M0D48_08355	COG3291	Pkd domain containing protein
M0D48_08360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M0D48_08385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M0D48_08400	COG0343	queuine tRNA-ribosyltransferase activity
M0D48_08405	COG1862	Preprotein translocase
M0D48_08415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M0D48_08450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M0D48_08450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M0D48_08455	COG1105	Belongs to the carbohydrate kinase PfkB family
M0D48_08460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M0D48_08460	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D48_08470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D48_08475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_08485	COG2902	Dehydrogenase
M0D48_08530	COG0477	Major facilitator Superfamily
M0D48_08540	COG2205	protein histidine kinase activity
M0D48_08540	COG5002	protein histidine kinase activity
M0D48_08540	COG0784	Response regulator, receiver
M0D48_08545	COG2733	membrane
M0D48_08555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M0D48_08565	COG2223	nitrite transmembrane transporter activity
M0D48_08570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M0D48_08575	COG0243	molybdopterin cofactor binding
M0D48_08585	COG0477	Major facilitator Superfamily
M0D48_08595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D48_08600	COG0174	glutamine synthetase
M0D48_08605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M0D48_08620	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M0D48_08640	COG3842	ATPase activity
M0D48_08645	COG1176	ABC-type spermidine putrescine transport system, permease component I
M0D48_08650	COG1177	transmembrane transport
M0D48_08660	COG1012	belongs to the aldehyde dehydrogenase family
M0D48_08675	COG4535	Mg2 and Co2 transporter CorC
M0D48_08685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M0D48_08695	COG1702	phosphate starvation-inducible protein PhoH
M0D48_08715	COG0741	lytic transglycosylase activity
M0D48_08720	COG0723	plastoquinol--plastocyanin reductase activity
M0D48_08725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M0D48_08730	COG2857	Cytochrome c1
M0D48_08735	COG0625	glutathione transferase activity
M0D48_08740	COG2969	positive regulation of protein catabolic process
M0D48_08765	COG1201	RNA secondary structure unwinding
M0D48_08775	COG0835	chemotaxis
M0D48_08820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M0D48_08830	COG1570	exodeoxyribonuclease VII activity
M0D48_08840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M0D48_08840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M0D48_08845	COG0802	atpase or kinase
M0D48_08850	COG0860	N-Acetylmuramoyl-L-alanine amidase
M0D48_08855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M0D48_08875	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_08880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D48_08885	COG0501	Belongs to the peptidase M48B family
M0D48_08900	COG4681	YaeQ
M0D48_08905	COG1671	Belongs to the UPF0178 family
M0D48_08915	COG0625	glutathione transferase activity
M0D48_08925	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M0D48_08930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M0D48_08935	COG0513	Belongs to the DEAD box helicase family
M0D48_08940	COG0488	(ABC) transporter
M0D48_08955	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M0D48_08960	COG0483	inositol monophosphate 1-phosphatase activity
M0D48_08975	COG5001	Diguanylate cyclase
M0D48_08975	COG3300	MHYT domain
M0D48_08980	COG1509	lysine 2,3-aminomutase activity
M0D48_08995	COG0402	S-adenosylhomocysteine deaminase activity
M0D48_09000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M0D48_09020	COG4677	pectinesterase activity
M0D48_09040	COG4302	ethanolamine ammonia-lyase activity
M0D48_09060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M0D48_09090	COG2166	iron-sulfur cluster assembly
M0D48_09095	COG0215	cysteine-tRNA ligase activity
M0D48_09105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M0D48_09110	COG0137	argininosuccinate synthase activity
M0D48_09115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D48_09120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M0D48_09135	COG0165	Argininosuccinate lyase
M0D48_09200	COG1294	oxidase, subunit
M0D48_09210	COG4988	ABC transporter
M0D48_09215	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M0D48_09225	COG1278	Cold shock
M0D48_09230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D48_09255	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M0D48_09275	COG4133	protoheme IX ABC transporter activity
M0D48_09280	COG0436	Aminotransferase
M0D48_09300	COG1187	pseudouridine synthase activity
M0D48_09305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M0D48_09310	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M0D48_09315	COG2350	Protein conserved in bacteria
M0D48_09345	COG1175	transmembrane transport
M0D48_09350	COG0395	ABC-type sugar transport system, permease component
M0D48_09375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M0D48_09380	COG2957	Belongs to the agmatine deiminase family
M0D48_09395	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M0D48_09400	COG0539	negative regulation of cytoplasmic translation
M0D48_09405	COG0776	regulation of translation
M0D48_09415	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M0D48_09420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M0D48_09430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M0D48_09435	COG0475	glutathione-regulated potassium exporter activity
M0D48_09435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M0D48_09445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M0D48_09465	COG3002	Belongs to the UPF0753 family
M0D48_09470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M0D48_09475	COG0583	DNA-binding transcription factor activity
M0D48_09480	COG0583	DNA-binding transcription factor activity
M0D48_09485	COG0583	DNA-binding transcription factor activity
M0D48_09505	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_09525	COG2197	response regulator
M0D48_09540	COG1335	isochorismatase
M0D48_09555	COG2814	Major facilitator Superfamily
M0D48_09570	COG1914	H( )-stimulated, divalent metal cation uptake system
M0D48_09580	COG0590	tRNA wobble adenosine to inosine editing
M0D48_09590	COG0668	transmembrane transport
M0D48_09600	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M0D48_09615	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_09620	COG1183	phosphatidylcholine synthase activity
M0D48_09630	COG3243	poly(R)-hydroxyalkanoic acid synthase
M0D48_09645	COG0723	plastoquinol--plastocyanin reductase activity
M0D48_09645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D48_09655	COG2183	response to ionizing radiation
M0D48_09660	COG2205	protein histidine kinase activity
M0D48_09660	COG5002	protein histidine kinase activity
M0D48_09660	COG0784	Response regulator, receiver
M0D48_09730	COG0129	dihydroxy-acid dehydratase activity
M0D48_09735	COG0363	glucosamine-6-phosphate deaminase activity
M0D48_09740	COG0837	glucose binding
M0D48_09745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M0D48_09770	COG2009	succinate dehydrogenase
M0D48_09775	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M0D48_09790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M0D48_09795	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M0D48_09805	COG4591	ABC-type transport system involved in lipoprotein release permease component
M0D48_09825	COG0811	peptide transport
M0D48_09840	COG1663	tetraacyldisaccharide 4'-kinase activity
M0D48_09845	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M0D48_09850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M0D48_09860	COG0322	excinuclease ABC activity
M0D48_09910	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M0D48_09930	COG1054	Belongs to the UPF0176 family
M0D48_09940	COG1530	ribonuclease E activity
M0D48_09945	COG0564	pseudouridine synthase activity
M0D48_09950	COG3064	Membrane
M0D48_09955	COG0428	transporter
M0D48_09965	COG2154	pterin-4-alpha-carbinolamine dehydratase
M0D48_10070	COG0631	protein serine/threonine phosphatase activity
M0D48_10075	COG0515	serine threonine protein kinase
M0D48_10100	COG1858	cytochrome C peroxidase
M0D48_10125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_10130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D48_10155	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M0D48_10160	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_10175	COG0653	protein targeting
M0D48_10190	COG0653	protein targeting
M0D48_10205	COG0653	protein targeting
M0D48_10225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D48_10230	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D48_10235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D48_10250	COG1024	Enoyl-CoA hydratase
M0D48_10260	COG1024	Enoyl-CoA hydratase
M0D48_10265	COG1024	Enoyl-CoA hydratase
M0D48_10270	COG3424	synthase
M0D48_10280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M0D48_10315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M0D48_10345	COG1304	FMN binding
M0D48_10350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M0D48_10370	COG0363	glucosamine-6-phosphate deaminase activity
M0D48_10390	COG1238	metal cluster binding
M0D48_10420	COG3279	Response regulator of the LytR AlgR family
M0D48_10425	COG3275	phosphorelay sensor kinase activity
M0D48_10460	COG4566	intracellular signal transduction
M0D48_10470	COG5001	Diguanylate cyclase
M0D48_10500	COG0243	molybdopterin cofactor binding
M0D48_10510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M0D48_10515	COG2223	nitrite transmembrane transporter activity
M0D48_10520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M0D48_10530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M0D48_10530	COG1648	precorrin-2 dehydrogenase activity
M0D48_10540	COG0746	molybdenum cofactor guanylyltransferase activity
M0D48_10545	COG0303	'Molybdopterin
M0D48_10555	COG0708	Exodeoxyribonuclease III
M0D48_10565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M0D48_10570	COG0303	'Molybdopterin
M0D48_10575	COG1160	GTP binding
M0D48_10580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D48_10600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M0D48_10615	COG1250	3-hydroxyacyl-CoA dehydrogenase
M0D48_10615	COG1024	Enoyl-CoA hydratase
M0D48_10620	COG0183	Belongs to the thiolase family
M0D48_10625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M0D48_10630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M0D48_10650	COG1674	ftsk spoiiie
M0D48_10655	COG0492	ferredoxin-NADP+ reductase activity
M0D48_10665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M0D48_10675	COG0542	response to heat
M0D48_10695	COG0482	sulfurtransferase activity
M0D48_10735	COG5002	protein histidine kinase activity
M0D48_10755	COG0835	chemotaxis
M0D48_10755	COG0784	Response regulator, receiver
M0D48_10765	COG1558	bacterial-type flagellum-dependent cell motility
M0D48_10770	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M0D48_10780	COG4787	bacterial-type flagellum-dependent cell motility
M0D48_10790	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M0D48_10795	COG1706	bacterial-type flagellum-dependent cell motility
M0D48_10800	COG1705	Flagellar rod assembly protein muramidase FlgJ
M0D48_10800	COG3951	Flagellar rod assembly protein muramidase FlgJ
M0D48_10810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M0D48_10820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M0D48_10825	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M0D48_10855	COG2201	protein-glutamate methylesterase activity
M0D48_10875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D48_10880	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_10885	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_10950	COG1677	Flagellar hook-basal body complex protein FliE
M0D48_11000	COG3190	flagellar
M0D48_11015	COG1684	flagellar biosynthetic protein fliR
M0D48_11070	COG0643	Histidine kinase
M0D48_11070	COG0784	Response regulator, receiver
M0D48_11070	COG2198	Histidine kinase
M0D48_11140	COG0793	Belongs to the peptidase S41A family
M0D48_11145	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M0D48_11150	COG1360	Flagellar Motor Protein
M0D48_11155	COG1192	Involved in chromosome partitioning
M0D48_11160	COG0835	chemotaxis
M0D48_11170	COG0745	RESPONSE REGULATOR receiver
M0D48_11180	COG0840	transmembrane signaling receptor activity
M0D48_11190	COG0840	transmembrane signaling receptor activity
M0D48_11195	COG0840	transmembrane signaling receptor activity
M0D48_11205	COG0840	transmembrane signaling receptor activity
M0D48_11210	COG0840	transmembrane signaling receptor activity
M0D48_11220	COG0840	transmembrane signaling receptor activity
M0D48_11225	COG0840	transmembrane signaling receptor activity
M0D48_11230	COG0840	transmembrane signaling receptor activity
M0D48_11235	COG0840	transmembrane signaling receptor activity
M0D48_11240	COG0840	transmembrane signaling receptor activity
M0D48_11245	COG0840	transmembrane signaling receptor activity
M0D48_11255	COG0835	chemotaxis
M0D48_11265	COG0840	transmembrane signaling receptor activity
M0D48_11295	COG2267	carboxylic ester hydrolase activity
M0D48_11325	COG0318	PFAM AMP-dependent synthetase and ligase
M0D48_11330	COG1024	Enoyl-CoA hydratase
M0D48_11335	COG0784	Response regulator, receiver
M0D48_11335	COG2198	Histidine kinase
M0D48_11335	COG2205	protein histidine kinase activity
M0D48_11345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M0D48_11355	COG3279	Response regulator of the LytR AlgR family
M0D48_11370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M0D48_11380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D48_11385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M0D48_11395	COG0505	Belongs to the CarA family
M0D48_11400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M0D48_11410	COG2258	MOSC domain
M0D48_11415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M0D48_11460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M0D48_11480	COG0277	FAD linked oxidase domain protein
M0D48_11485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M0D48_11495	COG0531	amino acid
M0D48_11500	COG0531	amino acid
M0D48_11505	COG0235	Class ii aldolase
M0D48_11510	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M0D48_11530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M0D48_11530	COG0140	phosphoribosyl-ATP diphosphatase activity
M0D48_11535	COG0107	imidazoleglycerol-phosphate synthase activity
M0D48_11540	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M0D48_11545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M0D48_11550	COG0131	Imidazoleglycerol-phosphate dehydratase
M0D48_11550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M0D48_11555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D48_11560	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M0D48_11575	COG0124	histidyl-tRNA synthetase
M0D48_11585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M0D48_11595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M0D48_11670	COG1012	belongs to the aldehyde dehydrogenase family
M0D48_11685	COG0167	dihydroorotate dehydrogenase activity
M0D48_11690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M0D48_11695	COG0697	spore germination
M0D48_11700	COG1794	racemase activity, acting on amino acids and derivatives
M0D48_11710	COG0671	phosphoesterase, PA-phosphatase related
M0D48_11715	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M0D48_11725	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
M0D48_11730	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D48_11735	COG2203	Gaf domain
M0D48_11735	COG5001	Diguanylate cyclase
M0D48_11735	COG4251	negative regulation of phosphorylation
M0D48_11735	COG3706	GGDEF domain
M0D48_11745	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D48_11775	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M0D48_11780	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M0D48_11785	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M0D48_11795	COG0617	tRNA 3'-terminal CCA addition
M0D48_11805	COG1469	GTP cyclohydrolase I activity
M0D48_11810	COG0860	N-Acetylmuramoyl-L-alanine amidase
M0D48_11830	COG0477	Major facilitator Superfamily
M0D48_11840	COG1070	Carbohydrate kinase
M0D48_11850	COG1501	Belongs to the glycosyl hydrolase 31 family
M0D48_11890	COG0800	Aldolase
M0D48_11895	COG4948	Mandelate Racemase Muconate Lactonizing
M0D48_11905	COG3734	2-keto-3-deoxy-galactonokinase
M0D48_11910	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M0D48_11920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M0D48_11935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M0D48_11940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M0D48_11955	COG0352	thiamine-phosphate diphosphorylase activity
M0D48_11955	COG0351	phosphomethylpyrimidine kinase
M0D48_11980	COG0583	DNA-binding transcription factor activity
M0D48_11985	COG1741	Belongs to the pirin family
M0D48_12000	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M0D48_12005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M0D48_12010	COG2137	regulation of response to DNA damage stimulus
M0D48_12015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M0D48_12025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D48_12030	COG1546	Belongs to the CinA family
M0D48_12035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M0D48_12050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M0D48_12055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M0D48_12060	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M0D48_12065	COG1534	Rna-binding protein
M0D48_12070	COG3737	Protein of unknown function (DUF498/DUF598)
M0D48_12080	COG1238	metal cluster binding
M0D48_12085	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M0D48_12090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M0D48_12095	COG2840	Smr protein MutS2
M0D48_12100	COG0585	pseudouridine synthase activity
M0D48_12105	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M0D48_12115	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M0D48_12120	COG0148	phosphopyruvate hydratase activity
M0D48_12135	COG0504	CTP synthase activity
M0D48_12160	COG0306	phosphate transporter
M0D48_12170	COG1253	flavin adenine dinucleotide binding
M0D48_12185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M0D48_12190	COG0477	Major facilitator Superfamily
M0D48_12195	COG1132	(ABC) transporter
M0D48_12200	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M0D48_12215	COG0438	transferase activity, transferring glycosyl groups
M0D48_12225	COG2264	protein methyltransferase activity
M0D48_12230	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M0D48_12255	COG2244	polysaccharide biosynthetic process
M0D48_12320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M0D48_12330	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M0D48_12340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D48_12355	COG0784	Response regulator, receiver
M0D48_12355	COG4191	Histidine kinase
M0D48_12360	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M0D48_12365	COG0784	Response regulator, receiver
M0D48_12365	COG2205	protein histidine kinase activity
M0D48_12365	COG5002	protein histidine kinase activity
M0D48_12385	COG0840	transmembrane signaling receptor activity
M0D48_12450	COG2003	Belongs to the UPF0758 family
M0D48_12540	COG0583	DNA-binding transcription factor activity
M0D48_12545	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M0D48_12550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M0D48_12565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M0D48_12570	COG1605	Chorismate mutase
M0D48_12570	COG0077	Prephenate dehydratase
M0D48_12575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M0D48_12580	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M0D48_12585	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
M0D48_12620	COG1228	amidohydrolase
M0D48_12625	COG2986	histidine ammonia-lyase
M0D48_12635	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M0D48_12650	COG4993	Dehydrogenase
M0D48_12665	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M0D48_12680	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M0D48_12685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M0D48_12690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D48_12700	COG3115	cell septum assembly
M0D48_12720	COG0360	Binds together with S18 to 16S ribosomal RNA
M0D48_12725	COG0316	Belongs to the HesB IscA family
M0D48_12730	COG0017	Asparaginyl-tRNA synthetase
M0D48_12755	COG0288	reversible hydration of carbon dioxide
M0D48_12770	COG3844	kynureninase activity
M0D48_12775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D48_12780	COG2925	Exonuclease
M0D48_12790	COG0667	Aldo Keto reductase
M0D48_12805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M0D48_12810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M0D48_12810	COG0116	Belongs to the methyltransferase superfamily
M0D48_12860	COG1024	Enoyl-CoA hydratase
M0D48_12870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M0D48_12875	COG0659	secondary active sulfate transmembrane transporter activity
M0D48_12900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M0D48_12905	COG0573	inorganic phosphate transmembrane transporter activity
M0D48_12910	COG0581	inorganic phosphate transmembrane transporter activity
M0D48_12920	COG0704	Plays a role in the regulation of phosphate uptake
M0D48_12930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M0D48_12940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M0D48_12950	COG0557	exoribonuclease II activity
M0D48_12965	COG1960	acyl-CoA dehydrogenase activity
M0D48_12970	COG2226	methyltransferase
M0D48_12975	COG0646	methionine synthase
M0D48_12975	COG1410	methionine synthase
M0D48_12985	COG0646	methionine synthase
M0D48_12985	COG1410	methionine synthase
M0D48_12995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D48_13020	COG2900	Belongs to the SlyX family
M0D48_13035	COG0386	Belongs to the glutathione peroxidase family
M0D48_13045	COG1725	Transcriptional regulator
M0D48_13050	COG1131	(ABC) transporter
M0D48_13085	COG1253	flavin adenine dinucleotide binding
M0D48_13110	COG2850	peptidyl-arginine hydroxylation
M0D48_13150	COG1132	(ABC) transporter
M0D48_13160	COG0583	DNA-binding transcription factor activity
M0D48_13190	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M0D48_13205	COG0443	Heat shock 70 kDa protein
M0D48_13210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M0D48_13215	COG1420	regulation of RNA biosynthetic process
M0D48_13220	COG0497	DNA recombination
M0D48_13230	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D48_13235	COG2914	Belongs to the UPF0125 (RnfH) family
M0D48_13245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M0D48_13315	COG2814	Major facilitator Superfamily
M0D48_13455	COG2003	Belongs to the UPF0758 family
M0D48_13530	COG3706	GGDEF domain
M0D48_13560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D48_13575	COG0583	DNA-binding transcription factor activity
M0D48_13585	COG0415	Belongs to the DNA photolyase family
M0D48_13590	COG0305	Participates in initiation and elongation during chromosome replication
M0D48_13600	COG0367	asparagine synthase
M0D48_13620	COG1960	acyl-CoA dehydrogenase activity
M0D48_13635	COG0084	hydrolase, TatD family'
M0D48_13640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M0D48_13680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M0D48_13735	COG0386	Belongs to the glutathione peroxidase family
M0D48_13740	COG0339	signal peptide processing
M0D48_13820	COG2814	Major facilitator Superfamily
M0D48_13825	COG1566	PFAM secretion protein HlyD family protein
M0D48_13850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M0D48_13870	COG0300	oxidoreductase activity
M0D48_13875	COG4774	siderophore transport
M0D48_13885	COG0367	asparagine synthase
M0D48_13890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D48_13900	COG1393	Belongs to the ArsC family
M0D48_13915	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M0D48_13960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M0D48_13970	COG0528	UMP kinase activity
M0D48_13975	COG0233	cytoplasmic translational termination
M0D48_13985	COG0575	Belongs to the CDS family
M0D48_13990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M0D48_13995	COG0750	zinc metalloprotease
M0D48_14010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D48_14020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D48_14025	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D48_14030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M0D48_14040	COG0825	malonyl-CoA metabolic process
M0D48_14065	COG1981	membrane
M0D48_14085	COG1695	Transcriptional regulator
M0D48_14105	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M0D48_14125	COG2040	homocysteine
M0D48_14130	COG0833	amino acid
M0D48_14135	COG0346	lactoylglutathione lyase activity
M0D48_14140	COG1131	(ABC) transporter
M0D48_14155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D48_14155	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D48_14165	COG2878	Part of a membrane complex involved in electron transport
M0D48_14180	COG1595	DNA-templated transcription, initiation
M0D48_14205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M0D48_14220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M0D48_14225	COG0251	oxidation-reduction process
M0D48_14235	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M0D48_14235	COG0392	lysyltransferase activity
M0D48_14270	COG2814	Major facilitator Superfamily
M0D48_14275	COG1902	pentaerythritol trinitrate reductase activity
M0D48_14280	COG2824	Alkylphosphonate utilization operon protein PhnA
M0D48_14290	COG1047	Peptidyl-prolyl cis-trans
M0D48_14325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M0D48_14335	COG5487	UPF0391 membrane protein
M0D48_14340	COG1451	nucleotide metabolic process
M0D48_14365	COG0183	Belongs to the thiolase family
M0D48_14395	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M0D48_14395	COG1793	dna ligase
M0D48_14405	COG1793	dna ligase
M0D48_14410	COG1201	RNA secondary structure unwinding
M0D48_14430	COG1278	Cold shock
M0D48_14435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M0D48_14440	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M0D48_14445	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D48_14450	COG3046	protein related to deoxyribodipyrimidine photolyase
M0D48_14455	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
M0D48_14460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M0D48_14465	COG2954	triphosphatase activity
M0D48_14480	COG1381	Involved in DNA repair and RecF pathway recombination
M0D48_14490	COG0571	ribonuclease III activity
M0D48_14505	COG0481	GTPase activity
M0D48_14510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M0D48_14550	COG1024	Enoyl-CoA hydratase
M0D48_14555	COG1960	acyl-CoA dehydrogenase activity
M0D48_14575	COG3867	Arabinogalactan endo-beta-1,4-galactanase
M0D48_14580	COG3250	beta-galactosidase activity
M0D48_14595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M0D48_14600	COG1121	(ABC) transporter
M0D48_14610	COG0803	Belongs to the bacterial solute-binding protein 9 family
M0D48_14615	COG0523	cobalamin synthesis protein
M0D48_14625	COG4774	siderophore transport
M0D48_14645	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M0D48_14655	COG0534	Mate efflux family protein
M0D48_14665	COG0336	Belongs to the RNA methyltransferase TrmD family
M0D48_14670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M0D48_14675	COG0228	four-way junction DNA binding
M0D48_14685	COG2070	2-Nitropropane dioxygenase
M0D48_14695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M0D48_14700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M0D48_14715	COG0583	DNA-binding transcription factor activity
M0D48_14735	COG4191	Histidine kinase
M0D48_14735	COG0784	Response regulator, receiver
M0D48_14740	COG4999	Histidine kinase
M0D48_14740	COG3850	Histidine kinase
M0D48_14740	COG2205	protein histidine kinase activity
M0D48_14740	COG3437	response regulator, receiver
M0D48_14745	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M0D48_14760	COG5507	3-demethylubiquinone-9 3-methyltransferase
M0D48_14770	COG4771	TonB-dependent receptor
M0D48_14795	COG2172	sigma factor antagonist activity
M0D48_14800	COG1366	Belongs to the anti-sigma-factor antagonist family
M0D48_14805	COG1366	Belongs to the anti-sigma-factor antagonist family
M0D48_14815	COG0326	Molecular chaperone. Has ATPase activity
M0D48_14820	COG2207	Transcriptional regulator
M0D48_14830	COG3152	Membrane
M0D48_14840	COG0156	8-amino-7-oxononanoate synthase activity
M0D48_14850	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M0D48_14855	COG1845	cytochrome c oxidase, subunit III
M0D48_14860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M0D48_14880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M0D48_14885	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M0D48_14890	COG0196	riboflavin kinase activity
M0D48_14900	COG0268	Binds directly to 16S ribosomal RNA
M0D48_14910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M0D48_14920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M0D48_14925	COG0824	Thioesterase
M0D48_14940	COG1946	Acyl-CoA thioesterase
M0D48_14950	COG1595	DNA-templated transcription, initiation
M0D48_14965	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M0D48_14985	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M0D48_15010	COG1073	alpha beta
M0D48_15030	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M0D48_15045	COG2197	response regulator
M0D48_15050	COG4585	Histidine kinase
M0D48_15065	COG2894	cell division
M0D48_15070	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M0D48_15080	COG0642	Histidine kinase
M0D48_15085	COG0745	RESPONSE REGULATOR receiver
M0D48_15090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M0D48_15100	COG2194	sulfuric ester hydrolase activity
M0D48_15115	COG2814	Major facilitator Superfamily
M0D48_15140	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M0D48_15140	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M0D48_15150	COG0656	L-ascorbic acid biosynthetic process
M0D48_15155	COG0753	catalase activity
M0D48_15180	COG1917	Cupin 2, conserved barrel domain protein
M0D48_15180	COG2207	Transcriptional regulator
M0D48_15190	COG0823	Involved in the tonB-independent uptake of proteins
M0D48_15190	COG1506	peptidase
M0D48_15200	COG1297	OPT oligopeptide transporter protein
M0D48_15225	COG0587	DNA-directed DNA polymerase activity
M0D48_15275	COG2080	2 iron, 2 sulfur cluster binding
M0D48_15280	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M0D48_15285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M0D48_15295	COG1064	alcohol dehydrogenase
M0D48_15330	COG3537	Alpha-1,2-mannosidase
M0D48_15340	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_15380	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
M0D48_15390	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M0D48_15395	COG0732	type I restriction modification DNA specificity domain
M0D48_15410	COG1309	transcriptional regulator
M0D48_15415	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_15430	COG0308	aminopeptidase N
M0D48_15450	COG0330	HflC and HflK could
M0D48_15455	COG0330	HflC and HflK could
M0D48_15475	COG0678	peroxiredoxin activity
M0D48_15485	COG4953	penicillin-binding protein 1C
M0D48_15500	COG2373	Large extracellular alpha-helical protein
M0D48_15525	COG3609	addiction module antidote protein, CC2985 family
M0D48_15545	COG3829	transcription factor binding
M0D48_15570	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M0D48_15575	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M0D48_15585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M0D48_15605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D48_15610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M0D48_15615	COG1399	metal-binding, possibly nucleic acid-binding protein
M0D48_15635	COG0714	Associated with various cellular activities
M0D48_15655	COG0537	adenosine 5'-monophosphoramidase activity
M0D48_15665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M0D48_15725	COG0314	molybdopterin synthase activity
M0D48_15730	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M0D48_15735	COG0315	cyclic pyranopterin monophosphate synthase activity
M0D48_15745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M0D48_15755	COG3642	lipopolysaccharide core region biosynthetic process
M0D48_15760	COG0859	PFAM glycosyl transferase family 9
M0D48_15775	COG0631	protein serine/threonine phosphatase activity
M0D48_15785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M0D48_15810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M0D48_15840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M0D48_15850	COG0544	peptidyl-prolyl cis-trans isomerase activity
M0D48_15860	COG4191	Histidine kinase
M0D48_15860	COG0784	Response regulator, receiver
M0D48_15895	COG0473	3-isopropylmalate dehydrogenase activity
M0D48_15910	COG4783	chaperone-mediated protein folding
M0D48_15925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M0D48_15935	COG0438	transferase activity, transferring glycosyl groups
M0D48_15940	COG0671	phosphoesterase, PA-phosphatase related
M0D48_15945	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D48_15955	COG3291	Pkd domain containing protein
M0D48_15960	COG2833	Protein of unknown function (DUF455)
M0D48_15985	COG0285	dihydrofolate synthase activity
M0D48_16000	COG0406	alpha-ribazole phosphatase activity
M0D48_16030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M0D48_16035	COG4208	sulfate ABC transporter
M0D48_16040	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M0D48_16045	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M0D48_16050	COG0156	8-amino-7-oxononanoate synthase activity
M0D48_16070	COG2885	chlorophyll binding
M0D48_16075	COG0604	alcohol dehydrogenase
M0D48_16080	COG0446	pyridine nucleotide-disulphide oxidoreductase
M0D48_16080	COG1902	pentaerythritol trinitrate reductase activity
M0D48_16095	COG0625	glutathione transferase activity
M0D48_16105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M0D48_16110	COG1217	gtp-binding protein TYPA
M0D48_16120	COG0154	amidase activity
M0D48_16130	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M0D48_16140	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M0D48_16145	COG0203	ribosomal protein L17
M0D48_16170	COG0201	protein transport
M0D48_16175	COG0200	Binds to the 23S rRNA
M0D48_16180	COG1841	ribosomal large subunit assembly
M0D48_16195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M0D48_16215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M0D48_16225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M0D48_16230	COG0255	Belongs to the universal ribosomal protein uL29 family
M0D48_16245	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M0D48_16255	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M0D48_16265	COG0088	Forms part of the polypeptide exit tunnel
M0D48_16275	COG0051	transcription antitermination factor activity, RNA binding
M0D48_16290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M0D48_16295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M0D48_16300	COG0049	tRNA binding
M0D48_16305	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M0D48_16310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M0D48_16315	COG0085	RNA polymerase activity
M0D48_16325	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M0D48_16330	COG0081	regulation of translation
M0D48_16335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M0D48_16340	COG0250	Participates in transcription elongation, termination and antitermination
M0D48_16345	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M0D48_16355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M0D48_16375	COG0012	GTP binding
M0D48_16380	COG0193	aminoacyl-tRNA hydrolase activity
M0D48_16385	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M0D48_16390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M0D48_16405	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M0D48_16415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M0D48_16420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M0D48_16430	COG0521	Mo-molybdopterin cofactor biosynthetic process
M0D48_16450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D48_16455	COG1295	ribonuclease BN
M0D48_16485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M0D48_16490	COG1404	Belongs to the peptidase S8 family
M0D48_16495	COG1404	Belongs to the peptidase S8 family
M0D48_16500	COG1404	Belongs to the peptidase S8 family
M0D48_16505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M0D48_16520	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M0D48_16545	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M0D48_16615	COG3634	alkyl hydroperoxide reductase activity
M0D48_16620	COG0583	DNA-binding transcription factor activity
M0D48_16630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D48_16635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M0D48_16645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M0D48_16655	COG2197	response regulator
M0D48_16660	COG5002	protein histidine kinase activity
M0D48_16660	COG2205	protein histidine kinase activity
M0D48_16660	COG0784	Response regulator, receiver
M0D48_16680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D48_16685	COG0697	spore germination
M0D48_16730	COG1024	Enoyl-CoA hydratase
M0D48_16740	COG0318	PFAM AMP-dependent synthetase and ligase
M0D48_16745	COG0583	DNA-binding transcription factor activity
M0D48_16750	COG3384	dioxygenase
M0D48_16760	COG1802	Transcriptional regulator
M0D48_16775	COG2267	carboxylic ester hydrolase activity
M0D48_16780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D48_16785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D48_16800	COG2096	Adenosyltransferase
M0D48_16805	COG0123	including yeast histone deacetylase and acetoin utilization protein
M0D48_16810	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M0D48_16820	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M0D48_16825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M0D48_16830	COG2967	ApaG domain
M0D48_16835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M0D48_16855	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M0D48_16875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M0D48_16885	COG0642	Histidine kinase
M0D48_16900	COG4181	ATPase activity
M0D48_16910	COG2175	clavaminate synthase activity
M0D48_16920	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M0D48_16925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M0D48_16945	COG4771	TonB-dependent receptor
M0D48_16955	COG0667	Aldo Keto reductase
M0D48_16960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M0D48_16965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D48_16980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M0D48_16985	COG4106	trans-aconitate 2-methyltransferase activity
M0D48_16995	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M0D48_17035	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M0D48_17050	COG2226	methyltransferase
M0D48_17090	COG0366	Alpha amylase catalytic
M0D48_17110	COG0604	alcohol dehydrogenase
M0D48_17110	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_17110	COG3321	synthase
M0D48_17120	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M0D48_17130	COG0494	nUDIX hydrolase
M0D48_17140	COG0653	protein targeting
M0D48_17145	COG0739	heme binding
M0D48_17155	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M0D48_17170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M0D48_17175	COG1181	Belongs to the D-alanine--D-alanine ligase family
M0D48_17180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M0D48_17185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M0D48_17195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M0D48_17200	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M0D48_17215	COG3116	cell division
M0D48_17260	COG0792	nuclease activity
M0D48_17265	COG1988	membrane-bound metal-dependent
M0D48_17270	COG0277	FAD linked oxidase domain protein
M0D48_17285	COG0745	RESPONSE REGULATOR receiver
M0D48_17290	COG2205	protein histidine kinase activity
M0D48_17300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M0D48_17305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M0D48_17325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M0D48_17330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M0D48_17335	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M0D48_17355	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M0D48_17355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M0D48_17370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M0D48_17385	COG0488	(ABC) transporter
M0D48_17390	COG0242	peptide deformylase activity
M0D48_17415	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M0D48_17460	COG2188	Transcriptional regulator
M0D48_17470	COG1450	Type ii and iii secretion system protein
M0D48_17485	COG3166	PFAM Fimbrial assembly family protein
M0D48_17490	COG3156	type II secretion system protein K
M0D48_17495	COG4795	General secretion pathway protein
M0D48_17500	COG2165	general secretion pathway protein
M0D48_17505	COG4970	Tfp pilus assembly protein FimT
M0D48_17510	COG2165	general secretion pathway protein
M0D48_17515	COG1459	type II secretion system
M0D48_17520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M0D48_17525	COG1404	Belongs to the peptidase S8 family
M0D48_17530	COG5295	Hep Hag repeat protein
M0D48_17540	COG0047	phosphoribosylformylglycinamidine synthase activity
M0D48_17540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M0D48_17545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M0D48_17550	COG4974	Belongs to the 'phage' integrase family
M0D48_17570	COG0795	lipopolysaccharide-transporting ATPase activity
M0D48_17580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M0D48_17595	COG0525	valine-tRNA ligase activity
M0D48_17625	COG0726	polysaccharide deacetylase
M0D48_17625	COG1649	PFAM Uncharacterised BCR, COG1649
M0D48_17630	COG1215	transferase activity, transferring glycosyl groups
M0D48_17645	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M0D48_17650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M0D48_17655	COG1609	Transcriptional regulator
M0D48_17665	COG2188	Transcriptional regulator
M0D48_17680	COG3250	beta-galactosidase activity
M0D48_17710	COG4795	General secretion pathway protein
M0D48_17730	COG1459	type II secretion system
M0D48_17785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M0D48_17790	COG4191	Histidine kinase
M0D48_17795	COG0784	Response regulator, receiver
M0D48_17800	COG4251	negative regulation of phosphorylation
M0D48_17805	COG2823	Periplasmic or secreted lipoprotein
M0D48_17810	COG0673	inositol 2-dehydrogenase activity
M0D48_17815	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M0D48_17850	COG1051	belongs to the nudix hydrolase family
M0D48_17850	COG1056	cytidyltransferase-related domain
M0D48_17860	COG0583	DNA-binding transcription factor activity
M0D48_17875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M0D48_17880	COG0321	lipoyl(octanoyl) transferase activity
M0D48_17885	COG2921	Belongs to the UPF0250 family
M0D48_17895	COG1686	Belongs to the peptidase S11 family
M0D48_17900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M0D48_17905	COG2951	lytic endotransglycosylase activity
M0D48_17910	COG5434	Belongs to the glycosyl hydrolase 28 family
M0D48_17920	COG0772	Belongs to the SEDS family
M0D48_17935	COG1792	Involved in formation and maintenance of cell shape
M0D48_17945	COG1077	Cell shape determining protein MreB Mrl
M0D48_17950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D48_17965	COG3284	Transcriptional regulator
M0D48_18010	COG0308	aminopeptidase N
M0D48_18015	COG5001	Diguanylate cyclase
M0D48_18015	COG3300	MHYT domain
M0D48_18020	COG2226	methyltransferase
M0D48_18035	COG2153	protein acetylation
M0D48_18045	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M0D48_18055	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M0D48_18065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M0D48_18075	COG2832	Protein of unknown function (DUF454)
M0D48_18085	COG0436	Aminotransferase
M0D48_18100	COG1505	serine-type exopeptidase activity
M0D48_18125	COG0181	hydroxymethylbilane synthase activity
M0D48_18135	COG3275	phosphorelay sensor kinase activity
M0D48_18145	COG2943	transferase activity, transferring hexosyl groups
M0D48_18160	COG0659	secondary active sulfate transmembrane transporter activity
M0D48_18165	COG5297	Belongs to the glycosyl hydrolase family 6
M0D48_18165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D48_18170	COG0840	transmembrane signaling receptor activity
M0D48_18235	COG0598	Magnesium transport protein CorA
M0D48_18245	COG1113	amino acid transport
M0D48_18255	COG5297	Belongs to the glycosyl hydrolase family 6
M0D48_18260	COG4305	rare lipoprotein A
M0D48_18265	COG0697	spore germination
M0D48_18330	COG0435	Glutathione S-transferase
M0D48_18340	COG4221	oxidoreductase activity
M0D48_18385	COG0210	DNA helicase
M0D48_18490	COG1802	Transcriptional regulator
M0D48_18500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M0D48_18525	COG3052	prosthetic group binding
M0D48_18560	COG1595	DNA-templated transcription, initiation
M0D48_18565	COG2353	YceI-like domain
M0D48_18570	COG0778	Nitroreductase
M0D48_18595	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M0D48_18600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M0D48_18610	COG3386	PFAM SMP-30 Gluconolaconase
M0D48_18625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M0D48_18640	COG3039	Transposase
M0D48_18675	COG0459	protein refolding
M0D48_18685	COG2356	endonuclease I
M0D48_18690	COG1324	tolerance protein
M0D48_18700	COG1505	serine-type exopeptidase activity
M0D48_18705	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M0D48_18710	COG0511	ligase activity, forming carbon-carbon bonds
M0D48_18720	COG0439	Biotin carboxylase
M0D48_18765	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M0D48_18780	COG0138	bifunctional purine biosynthesis protein purh
M0D48_18785	COG0151	Belongs to the GarS family
M0D48_18790	COG1289	transmembrane transporter activity
M0D48_18795	COG2814	Major facilitator Superfamily
M0D48_18805	COG2814	Major facilitator Superfamily
M0D48_18820	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M0D48_18835	COG0316	Belongs to the HesB IscA family
M0D48_18890	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M0D48_18900	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
M0D48_18915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M0D48_18925	COG0134	indole-3-glycerol-phosphate synthase activity
M0D48_18930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M0D48_18960	COG1597	lipid kinase activity
M0D48_18965	COG0456	acetyltransferase
M0D48_18970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M0D48_18980	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M0D48_19020	COG2111	Na H antiporter
M0D48_19020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M0D48_19025	COG1006	Multisubunit Na H antiporter MnhC subunit
M0D48_19030	COG0651	ATP synthesis coupled electron transport
M0D48_19040	COG2212	antiporter activity
M0D48_19045	COG1320	monovalent cation:proton antiporter activity
M0D48_19065	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M0D48_19085	COG3104	oligopeptide transport
M0D48_19100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M0D48_19125	COG0513	Belongs to the DEAD box helicase family
M0D48_19145	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_19165	COG0702	epimerase
M0D48_19190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M0D48_19195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M0D48_19200	COG0297	glycogen (starch) synthase activity
M0D48_19210	COG1649	PFAM Uncharacterised BCR, COG1649
M0D48_19215	COG2354	Protein conserved in bacteria
M0D48_19220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D48_19225	COG1368	sulfuric ester hydrolase activity
M0D48_19230	COG1511	domain protein
M0D48_19230	COG3264	Mechanosensitive ion channel
M0D48_19305	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M0D48_19385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M0D48_19390	COG1040	competence protein
M0D48_19395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M0D48_19400	COG0156	8-amino-7-oxononanoate synthase activity
M0D48_19415	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_19440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M0D48_19455	COG0445	tRNA wobble uridine modification
M0D48_19465	COG0657	acetylesterase activity
M0D48_19475	COG1414	Transcriptional regulator
M0D48_19490	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M0D48_19495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D48_19505	COG3485	protocatechuate 3,4-dioxygenase
M0D48_19510	COG3485	protocatechuate 3,4-dioxygenase
M0D48_19520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M0D48_19525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M0D48_19555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M0D48_19560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M0D48_19615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M0D48_19625	COG0129	dihydroxy-acid dehydratase activity
M0D48_19670	COG1733	regulation of RNA biosynthetic process
M0D48_19675	COG0702	epimerase
M0D48_19705	COG0583	DNA-binding transcription factor activity
M0D48_19710	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M0D48_19765	COG1902	pentaerythritol trinitrate reductase activity
M0D48_19770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M0D48_19775	COG0596	Alpha beta hydrolase
M0D48_19790	COG2814	Major facilitator Superfamily
M0D48_19795	COG0583	DNA-binding transcription factor activity
M0D48_19800	COG0084	hydrolase, TatD family'
M0D48_19820	COG2252	PERMEase
M0D48_19865	COG0596	Alpha beta hydrolase
M0D48_19880	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M0D48_19900	COG2072	flavoprotein involved in K transport
M0D48_19905	COG2351	hydroxyisourate hydrolase activity
M0D48_19910	COG4807	Protein conserved in bacteria
M0D48_19920	COG1643	Atp-dependent helicase
M0D48_19930	COG1187	pseudouridine synthase activity
M0D48_19945	COG2130	NADP-dependent
M0D48_19950	COG0656	L-ascorbic acid biosynthetic process
M0D48_19970	COG1764	response to oxidative stress
M0D48_19975	COG1846	Transcriptional regulator
M0D48_19980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M0D48_19990	COG0697	spore germination
M0D48_20000	COG0523	cobalamin synthesis protein
M0D48_20055	COG1960	acyl-CoA dehydrogenase activity
M0D48_20060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M0D48_20065	COG4770	biotin carboxylase activity
M0D48_20095	COG2224	Isocitrate lyase
M0D48_20100	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M0D48_20105	COG0583	DNA-binding transcription factor activity
M0D48_20110	COG0475	glutathione-regulated potassium exporter activity
M0D48_20140	COG0681	Belongs to the peptidase S26 family
M0D48_20145	COG0339	signal peptide processing
M0D48_20150	COG1446	asparaginase
M0D48_20170	COG0564	pseudouridine synthase activity
M0D48_20185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D48_20195	COG1181	Belongs to the D-alanine--D-alanine ligase family
M0D48_20205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D48_20210	COG0318	PFAM AMP-dependent synthetase and ligase
M0D48_20215	COG0727	PFAM Uncharacterised protein family (UPF0153)
M0D48_20220	COG0596	Alpha beta hydrolase
M0D48_20230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D48_20245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M0D48_20270	COG2205	protein histidine kinase activity
M0D48_20275	COG0028	Belongs to the TPP enzyme family
M0D48_20285	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M0D48_20290	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M0D48_20295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M0D48_20335	COG0183	Belongs to the thiolase family
M0D48_20350	COG2032	superoxide dismutase activity
M0D48_20355	COG2032	superoxide dismutase activity
M0D48_20360	COG2204	response regulator
M0D48_20365	COG3852	Histidine kinase
M0D48_20370	COG0004	ammonium transporteR
M0D48_20375	COG0347	Belongs to the P(II) protein family
M0D48_20380	COG0174	glutamine synthetase
M0D48_20385	COG1968	undecaprenyl-diphosphatase activity
M0D48_20425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D48_20435	COG2062	phosphohistidine phosphatase, SixA
M0D48_20440	COG0489	protein tyrosine kinase activity
M0D48_20460	COG3620	sequence-specific DNA binding
M0D48_20465	COG3550	peptidyl-serine autophosphorylation
M0D48_20470	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
M0D48_20475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M0D48_20490	COG0517	IMP dehydrogenase activity
M0D48_20490	COG1125	glycine betaine transport
M0D48_20505	COG1119	ATPase activity
M0D48_20515	COG1473	amidohydrolase
M0D48_20520	COG1752	Esterase of the alpha-beta hydrolase superfamily
M0D48_20530	COG1522	sequence-specific DNA binding
M0D48_20535	COG3186	Phenylalanine-4-hydroxylase
M0D48_20545	COG2755	lipolytic protein G-D-S-L family
M0D48_20555	COG1028	Short-chain dehydrogenase reductase Sdr
M0D48_20560	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M0D48_20565	COG1609	Transcriptional regulator
M0D48_20585	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M0D48_20595	COG0657	acetylesterase activity
M0D48_20595	COG2755	lipolytic protein G-D-S-L family
M0D48_20605	COG2755	lipolytic protein G-D-S-L family
M0D48_20645	COG0366	Alpha amylase catalytic
M0D48_20650	COG0366	Alpha amylase catalytic
M0D48_20655	COG2831	hemolysin activation secretion protein
M0D48_20660	COG3210	domain, Protein
M0D48_20670	COG3210	domain, Protein
M0D48_20685	COG3210	domain, Protein
M0D48_20725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M0D48_20765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D48_20775	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M0D48_20780	COG3710	Transcriptional regulator
M0D48_20800	COG2197	response regulator
M0D48_20805	COG4585	Histidine kinase
M0D48_20810	COG1755	Isoprenylcysteine carboxyl methyltransferase
M0D48_20815	COG1304	FMN binding
M0D48_20840	COG1012	belongs to the aldehyde dehydrogenase family
M0D48_20845	COG4772	TonB-dependent receptor
M0D48_20855	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M0D48_20905	COG0714	Associated with various cellular activities
M0D48_20945	COG0477	Major facilitator Superfamily
M0D48_20950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D48_21010	COG3237	CsbD-like
M0D48_21020	COG0625	glutathione transferase activity
M0D48_21030	COG1272	protein, Hemolysin III
M0D48_21035	COG1205	dead DEAH box helicase
M0D48_21035	COG1111	helicase
M0D48_21115	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M0D48_21145	COG1132	(ABC) transporter
M0D48_21175	COG0367	asparagine synthase
M0D48_21195	COG0438	transferase activity, transferring glycosyl groups
M0D48_21195	COG0297	glycogen (starch) synthase activity
M0D48_21200	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M0D48_21220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M0D48_21240	COG3459	Glycosyltransferase 36 associated
M0D48_21280	COG0067	glutamate synthase
M0D48_21280	COG0069	glutamate synthase activity
M0D48_21280	COG0070	glutamate synthase
M0D48_21285	COG0493	'glutamate synthase
M0D48_21300	COG1064	alcohol dehydrogenase
M0D48_21305	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D48_21310	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D48_21315	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D48_21325	COG2234	aminopeptidase activity
M0D48_21335	COG4942	peptidase
M0D48_21340	COG0793	Belongs to the peptidase S41A family
M0D48_21345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M0D48_21385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D48_21395	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M0D48_21430	COG0501	Belongs to the peptidase M48B family
M0D48_21440	COG0187	DNA topoisomerase II activity
M0D48_21455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M0D48_21475	COG0726	polysaccharide deacetylase
M0D48_21480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M0D48_21495	COG0584	glycerophosphoryl diester phosphodiesterase
M0D48_21505	COG0861	Integral membrane protein TerC family
M0D48_21510	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M0D48_21525	COG2271	Major facilitator Superfamily
M0D48_21530	COG1929	Belongs to the glycerate kinase type-1 family
M0D48_21535	COG3835	regulator
M0D48_21540	COG3706	GGDEF domain
M0D48_21560	COG3537	Alpha-1,2-mannosidase
M0D48_21565	COG0531	amino acid
M0D48_21585	COG0583	DNA-binding transcription factor activity
M0D48_21590	COG0604	alcohol dehydrogenase
M0D48_21595	COG1322	Protein conserved in bacteria
M0D48_21605	COG0386	Belongs to the glutathione peroxidase family
M0D48_21615	COG2853	Lipoprotein
M0D48_21635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M0D48_21640	COG1127	ABC transporter
M0D48_21645	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M0D48_21650	COG1074	ATP-dependent DNA helicase activity
M0D48_21695	COG0564	pseudouridine synthase activity
M0D48_21740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D48_21775	COG0477	Major facilitator Superfamily
M0D48_21780	COG1289	transmembrane transporter activity
M0D48_21790	COG1566	PFAM secretion protein HlyD family protein
M0D48_21805	COG0302	gtp cyclohydrolase
M0D48_21825	COG0730	response to heat
M0D48_21830	COG3012	SEC-C Motif Domain Protein
M0D48_21840	COG0676	glucose-6-phosphate 1-epimerase activity
M0D48_21860	COG3135	benzoate transporter