locus-tag	class	description
M0D46_00030	COG2850	peptidyl-arginine hydroxylation
M0D46_00040	COG0567	Dehydrogenase, E1 component
M0D46_00070	COG1132	(ABC) transporter
M0D46_00080	COG0583	DNA-binding transcription factor activity
M0D46_00110	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M0D46_00125	COG0443	Heat shock 70 kDa protein
M0D46_00130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M0D46_00135	COG1420	regulation of RNA biosynthetic process
M0D46_00140	COG0497	DNA recombination
M0D46_00150	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D46_00155	COG2914	Belongs to the UPF0125 (RnfH) family
M0D46_00165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M0D46_00200	COG3706	GGDEF domain
M0D46_00230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D46_00245	COG0583	DNA-binding transcription factor activity
M0D46_00255	COG0415	Belongs to the DNA photolyase family
M0D46_00260	COG0305	Participates in initiation and elongation during chromosome replication
M0D46_00270	COG0367	asparagine synthase
M0D46_00285	COG1960	acyl-CoA dehydrogenase activity
M0D46_00300	COG0084	hydrolase, TatD family'
M0D46_00305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M0D46_00345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M0D46_00395	COG0386	Belongs to the glutathione peroxidase family
M0D46_00400	COG0339	signal peptide processing
M0D46_00480	COG2814	Major facilitator Superfamily
M0D46_00485	COG1566	PFAM secretion protein HlyD family protein
M0D46_00510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M0D46_00530	COG0300	oxidoreductase activity
M0D46_00535	COG4774	siderophore transport
M0D46_00545	COG0367	asparagine synthase
M0D46_00550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D46_00560	COG1393	Belongs to the ArsC family
M0D46_00575	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M0D46_00620	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M0D46_00630	COG0528	UMP kinase activity
M0D46_00635	COG0233	cytoplasmic translational termination
M0D46_00645	COG0575	Belongs to the CDS family
M0D46_00650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M0D46_00655	COG0750	zinc metalloprotease
M0D46_00670	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D46_00680	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D46_00685	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D46_00700	COG0825	malonyl-CoA metabolic process
M0D46_00725	COG1981	membrane
M0D46_00745	COG1695	Transcriptional regulator
M0D46_00765	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M0D46_00785	COG2040	homocysteine
M0D46_00790	COG0833	amino acid
M0D46_00795	COG0346	lactoylglutathione lyase activity
M0D46_00800	COG1131	(ABC) transporter
M0D46_00825	COG2878	Part of a membrane complex involved in electron transport
M0D46_00840	COG1595	DNA-templated transcription, initiation
M0D46_00865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M0D46_00880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M0D46_00885	COG0251	oxidation-reduction process
M0D46_00895	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M0D46_00895	COG0392	lysyltransferase activity
M0D46_00930	COG2814	Major facilitator Superfamily
M0D46_00935	COG1902	pentaerythritol trinitrate reductase activity
M0D46_00940	COG2824	Alkylphosphonate utilization operon protein PhnA
M0D46_00950	COG1047	Peptidyl-prolyl cis-trans
M0D46_00985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M0D46_00995	COG5487	UPF0391 membrane protein
M0D46_01000	COG1451	nucleotide metabolic process
M0D46_01020	COG0183	Belongs to the thiolase family
M0D46_01050	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M0D46_01050	COG1793	dna ligase
M0D46_01060	COG1793	dna ligase
M0D46_01065	COG1201	RNA secondary structure unwinding
M0D46_01085	COG1278	Cold shock
M0D46_01090	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M0D46_01095	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M0D46_01100	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D46_01105	COG3046	protein related to deoxyribodipyrimidine photolyase
M0D46_01110	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
M0D46_01115	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M0D46_01120	COG2954	triphosphatase activity
M0D46_01135	COG1381	Involved in DNA repair and RecF pathway recombination
M0D46_01145	COG0571	ribonuclease III activity
M0D46_01160	COG0481	GTPase activity
M0D46_01165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M0D46_01205	COG1024	Enoyl-CoA hydratase
M0D46_01210	COG1960	acyl-CoA dehydrogenase activity
M0D46_01230	COG3867	Arabinogalactan endo-beta-1,4-galactanase
M0D46_01235	COG3250	beta-galactosidase activity
M0D46_01255	COG2801	Transposase and inactivated derivatives
M0D46_01265	COG3209	COG3209 Rhs family protein
M0D46_01275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M0D46_01280	COG1121	(ABC) transporter
M0D46_01290	COG0803	Belongs to the bacterial solute-binding protein 9 family
M0D46_01295	COG0523	cobalamin synthesis protein
M0D46_01330	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M0D46_01340	COG0534	Mate efflux family protein
M0D46_01350	COG0336	Belongs to the RNA methyltransferase TrmD family
M0D46_01355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M0D46_01360	COG0228	four-way junction DNA binding
M0D46_01370	COG2070	2-Nitropropane dioxygenase
M0D46_01380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M0D46_01385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M0D46_01400	COG0583	DNA-binding transcription factor activity
M0D46_01420	COG0784	Response regulator, receiver
M0D46_01420	COG4191	Histidine kinase
M0D46_01425	COG2205	protein histidine kinase activity
M0D46_01425	COG3850	Histidine kinase
M0D46_01425	COG4999	Histidine kinase
M0D46_01425	COG3437	response regulator, receiver
M0D46_01430	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M0D46_01445	COG5507	3-demethylubiquinone-9 3-methyltransferase
M0D46_01455	COG4771	TonB-dependent receptor
M0D46_01480	COG2172	sigma factor antagonist activity
M0D46_01485	COG1366	Belongs to the anti-sigma-factor antagonist family
M0D46_01490	COG1366	Belongs to the anti-sigma-factor antagonist family
M0D46_01500	COG0326	Molecular chaperone. Has ATPase activity
M0D46_01505	COG2207	Transcriptional regulator
M0D46_01525	COG0156	8-amino-7-oxononanoate synthase activity
M0D46_01535	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M0D46_01540	COG1845	cytochrome c oxidase, subunit III
M0D46_01545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M0D46_01565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M0D46_01575	COG0196	riboflavin kinase activity
M0D46_01585	COG0268	Binds directly to 16S ribosomal RNA
M0D46_01595	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M0D46_01605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M0D46_01610	COG0824	Thioesterase
M0D46_01625	COG1946	Acyl-CoA thioesterase
M0D46_01635	COG1595	DNA-templated transcription, initiation
M0D46_01650	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M0D46_01670	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M0D46_01695	COG1073	alpha beta
M0D46_01715	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M0D46_01730	COG2197	response regulator
M0D46_01735	COG4585	Histidine kinase
M0D46_01750	COG2894	cell division
M0D46_01755	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M0D46_01765	COG0642	Histidine kinase
M0D46_01770	COG0745	RESPONSE REGULATOR receiver
M0D46_01785	COG2194	sulfuric ester hydrolase activity
M0D46_01800	COG2814	Major facilitator Superfamily
M0D46_01825	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M0D46_01825	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M0D46_01835	COG0656	L-ascorbic acid biosynthetic process
M0D46_01840	COG0753	catalase activity
M0D46_01865	COG1917	Cupin 2, conserved barrel domain protein
M0D46_01865	COG2207	Transcriptional regulator
M0D46_01875	COG0823	Involved in the tonB-independent uptake of proteins
M0D46_01875	COG1506	peptidase
M0D46_01885	COG1297	OPT oligopeptide transporter protein
M0D46_01910	COG0587	DNA-directed DNA polymerase activity
M0D46_01925	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M0D46_01960	COG2080	2 iron, 2 sulfur cluster binding
M0D46_01965	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M0D46_01970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M0D46_01980	COG1064	alcohol dehydrogenase
M0D46_02015	COG3537	Alpha-1,2-mannosidase
M0D46_02025	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_02070	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
M0D46_02080	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M0D46_02100	COG1309	transcriptional regulator
M0D46_02105	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_02120	COG0308	aminopeptidase N
M0D46_02140	COG0330	HflC and HflK could
M0D46_02145	COG0330	HflC and HflK could
M0D46_02165	COG0678	peroxiredoxin activity
M0D46_02175	COG4953	penicillin-binding protein 1C
M0D46_02190	COG2373	Large extracellular alpha-helical protein
M0D46_02215	COG3609	addiction module antidote protein, CC2985 family
M0D46_02235	COG3829	transcription factor binding
M0D46_02260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M0D46_02265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M0D46_02275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M0D46_02295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D46_02300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M0D46_02305	COG1399	metal-binding, possibly nucleic acid-binding protein
M0D46_02325	COG0714	Associated with various cellular activities
M0D46_02345	COG0537	adenosine 5'-monophosphoramidase activity
M0D46_02355	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M0D46_02465	COG0314	molybdopterin synthase activity
M0D46_02470	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M0D46_02475	COG0315	cyclic pyranopterin monophosphate synthase activity
M0D46_02485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M0D46_02495	COG3642	lipopolysaccharide core region biosynthetic process
M0D46_02515	COG0631	protein serine/threonine phosphatase activity
M0D46_02525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M0D46_02550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M0D46_02580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M0D46_02590	COG0544	peptidyl-prolyl cis-trans isomerase activity
M0D46_02600	COG4191	Histidine kinase
M0D46_02600	COG0784	Response regulator, receiver
M0D46_02635	COG0473	3-isopropylmalate dehydrogenase activity
M0D46_02650	COG4783	chaperone-mediated protein folding
M0D46_02665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M0D46_02675	COG0438	transferase activity, transferring glycosyl groups
M0D46_02680	COG0671	phosphoesterase, PA-phosphatase related
M0D46_02685	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D46_02695	COG3291	Pkd domain containing protein
M0D46_02700	COG2833	Protein of unknown function (DUF455)
M0D46_02725	COG0285	dihydrofolate synthase activity
M0D46_02740	COG0406	alpha-ribazole phosphatase activity
M0D46_02770	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M0D46_02775	COG4208	sulfate ABC transporter
M0D46_02780	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M0D46_02785	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M0D46_02790	COG0156	8-amino-7-oxononanoate synthase activity
M0D46_02810	COG2885	chlorophyll binding
M0D46_02815	COG0604	alcohol dehydrogenase
M0D46_02820	COG1902	pentaerythritol trinitrate reductase activity
M0D46_02820	COG0446	pyridine nucleotide-disulphide oxidoreductase
M0D46_02835	COG0625	glutathione transferase activity
M0D46_02845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M0D46_02850	COG1217	gtp-binding protein TYPA
M0D46_02860	COG0154	amidase activity
M0D46_02870	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M0D46_02880	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M0D46_02885	COG0203	ribosomal protein L17
M0D46_02910	COG0201	protein transport
M0D46_02915	COG0200	Binds to the 23S rRNA
M0D46_02920	COG1841	ribosomal large subunit assembly
M0D46_02935	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M0D46_02955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M0D46_02965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M0D46_02970	COG0255	Belongs to the universal ribosomal protein uL29 family
M0D46_02985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M0D46_02995	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M0D46_03005	COG0088	Forms part of the polypeptide exit tunnel
M0D46_03015	COG0051	transcription antitermination factor activity, RNA binding
M0D46_03030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M0D46_03035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M0D46_03040	COG0049	tRNA binding
M0D46_03045	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M0D46_03050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M0D46_03055	COG0085	RNA polymerase activity
M0D46_03065	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M0D46_03070	COG0081	regulation of translation
M0D46_03075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M0D46_03080	COG0250	Participates in transcription elongation, termination and antitermination
M0D46_03085	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M0D46_03095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M0D46_03115	COG0012	GTP binding
M0D46_03120	COG0193	aminoacyl-tRNA hydrolase activity
M0D46_03125	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M0D46_03130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M0D46_03145	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M0D46_03155	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M0D46_03160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M0D46_03170	COG0521	Mo-molybdopterin cofactor biosynthetic process
M0D46_03190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D46_03195	COG1295	ribonuclease BN
M0D46_03225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M0D46_03230	COG1404	Belongs to the peptidase S8 family
M0D46_03235	COG1404	Belongs to the peptidase S8 family
M0D46_03240	COG1404	Belongs to the peptidase S8 family
M0D46_03245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M0D46_03260	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M0D46_03285	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M0D46_03350	COG3634	alkyl hydroperoxide reductase activity
M0D46_03355	COG0583	DNA-binding transcription factor activity
M0D46_03365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D46_03370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M0D46_03380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M0D46_03390	COG2197	response regulator
M0D46_03395	COG2205	protein histidine kinase activity
M0D46_03395	COG0784	Response regulator, receiver
M0D46_03395	COG5002	protein histidine kinase activity
M0D46_03415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D46_03420	COG0697	spore germination
M0D46_03465	COG1024	Enoyl-CoA hydratase
M0D46_03475	COG0318	PFAM AMP-dependent synthetase and ligase
M0D46_03480	COG0583	DNA-binding transcription factor activity
M0D46_03485	COG3384	dioxygenase
M0D46_03510	COG2267	carboxylic ester hydrolase activity
M0D46_03515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D46_03520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D46_03535	COG2096	Adenosyltransferase
M0D46_03540	COG0123	including yeast histone deacetylase and acetoin utilization protein
M0D46_03545	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M0D46_03555	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M0D46_03560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M0D46_03565	COG2967	ApaG domain
M0D46_03570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M0D46_03590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M0D46_03610	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M0D46_03620	COG0642	Histidine kinase
M0D46_03635	COG4181	ATPase activity
M0D46_03645	COG2175	clavaminate synthase activity
M0D46_03655	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M0D46_03660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M0D46_03680	COG4771	TonB-dependent receptor
M0D46_03690	COG0667	Aldo Keto reductase
M0D46_03695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M0D46_03700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D46_03715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M0D46_03720	COG4106	trans-aconitate 2-methyltransferase activity
M0D46_03730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M0D46_03770	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M0D46_03790	COG2226	methyltransferase
M0D46_03830	COG0366	Alpha amylase catalytic
M0D46_03850	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_03850	COG3321	synthase
M0D46_03850	COG0604	alcohol dehydrogenase
M0D46_03860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M0D46_03870	COG0494	nUDIX hydrolase
M0D46_03880	COG0653	protein targeting
M0D46_03885	COG0739	heme binding
M0D46_03895	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M0D46_03910	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M0D46_03915	COG1181	Belongs to the D-alanine--D-alanine ligase family
M0D46_03920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M0D46_03925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M0D46_03935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M0D46_03940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M0D46_03955	COG3116	cell division
M0D46_03995	COG0792	nuclease activity
M0D46_04000	COG1988	membrane-bound metal-dependent
M0D46_04005	COG0277	FAD linked oxidase domain protein
M0D46_04020	COG0745	RESPONSE REGULATOR receiver
M0D46_04025	COG2205	protein histidine kinase activity
M0D46_04035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M0D46_04040	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M0D46_04060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M0D46_04065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M0D46_04070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M0D46_04090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M0D46_04090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M0D46_04105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M0D46_04125	COG0488	(ABC) transporter
M0D46_04130	COG0242	peptide deformylase activity
M0D46_04155	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M0D46_04200	COG2188	Transcriptional regulator
M0D46_04210	COG1450	Type ii and iii secretion system protein
M0D46_04225	COG3166	PFAM Fimbrial assembly family protein
M0D46_04230	COG3156	type II secretion system protein K
M0D46_04235	COG4795	General secretion pathway protein
M0D46_04240	COG2165	general secretion pathway protein
M0D46_04245	COG4970	Tfp pilus assembly protein FimT
M0D46_04250	COG2165	general secretion pathway protein
M0D46_04255	COG1459	type II secretion system
M0D46_04260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M0D46_04265	COG1404	Belongs to the peptidase S8 family
M0D46_04270	COG5295	Hep Hag repeat protein
M0D46_04280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M0D46_04280	COG0047	phosphoribosylformylglycinamidine synthase activity
M0D46_04285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M0D46_04290	COG4974	Belongs to the 'phage' integrase family
M0D46_04310	COG0795	lipopolysaccharide-transporting ATPase activity
M0D46_04320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M0D46_04335	COG0525	valine-tRNA ligase activity
M0D46_04370	COG1649	PFAM Uncharacterised BCR, COG1649
M0D46_04370	COG0726	polysaccharide deacetylase
M0D46_04375	COG1215	transferase activity, transferring glycosyl groups
M0D46_04390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M0D46_04395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M0D46_04400	COG1609	Transcriptional regulator
M0D46_04410	COG2188	Transcriptional regulator
M0D46_04425	COG3250	beta-galactosidase activity
M0D46_04455	COG4795	General secretion pathway protein
M0D46_04470	COG2165	general secretion pathway protein
M0D46_04475	COG1459	type II secretion system
M0D46_04530	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M0D46_04535	COG4191	Histidine kinase
M0D46_04540	COG0784	Response regulator, receiver
M0D46_04545	COG4251	negative regulation of phosphorylation
M0D46_04550	COG2823	Periplasmic or secreted lipoprotein
M0D46_04555	COG0673	inositol 2-dehydrogenase activity
M0D46_04560	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M0D46_04595	COG1056	cytidyltransferase-related domain
M0D46_04595	COG1051	belongs to the nudix hydrolase family
M0D46_04605	COG0583	DNA-binding transcription factor activity
M0D46_04620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M0D46_04625	COG0321	lipoyl(octanoyl) transferase activity
M0D46_04630	COG2921	Belongs to the UPF0250 family
M0D46_04640	COG1686	Belongs to the peptidase S11 family
M0D46_04645	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M0D46_04650	COG2951	lytic endotransglycosylase activity
M0D46_04655	COG5434	Belongs to the glycosyl hydrolase 28 family
M0D46_04665	COG0772	Belongs to the SEDS family
M0D46_04680	COG1792	Involved in formation and maintenance of cell shape
M0D46_04690	COG1077	Cell shape determining protein MreB Mrl
M0D46_04695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D46_04710	COG3284	Transcriptional regulator
M0D46_04755	COG0308	aminopeptidase N
M0D46_04760	COG3300	MHYT domain
M0D46_04760	COG5001	Diguanylate cyclase
M0D46_04765	COG2226	methyltransferase
M0D46_04780	COG2153	protein acetylation
M0D46_04790	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M0D46_04800	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M0D46_04810	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M0D46_04820	COG2832	Protein of unknown function (DUF454)
M0D46_04830	COG0436	Aminotransferase
M0D46_04845	COG1505	serine-type exopeptidase activity
M0D46_04870	COG0181	hydroxymethylbilane synthase activity
M0D46_04880	COG3275	phosphorelay sensor kinase activity
M0D46_04905	COG0659	secondary active sulfate transmembrane transporter activity
M0D46_04910	COG5297	Belongs to the glycosyl hydrolase family 6
M0D46_04910	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D46_04915	COG0840	transmembrane signaling receptor activity
M0D46_04975	COG0598	Magnesium transport protein CorA
M0D46_04985	COG1113	amino acid transport
M0D46_04995	COG5297	Belongs to the glycosyl hydrolase family 6
M0D46_05000	COG4305	rare lipoprotein A
M0D46_05005	COG0697	spore germination
M0D46_05050	COG2409	Drug exporters of the RND superfamily
M0D46_05070	COG0435	Glutathione S-transferase
M0D46_05080	COG4221	oxidoreductase activity
M0D46_05165	COG0210	DNA helicase
M0D46_05300	COG1802	Transcriptional regulator
M0D46_05310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M0D46_05335	COG3052	prosthetic group binding
M0D46_05375	COG2353	YceI-like domain
M0D46_05380	COG0778	Nitroreductase
M0D46_05405	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M0D46_05410	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M0D46_05420	COG3386	PFAM SMP-30 Gluconolaconase
M0D46_05435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M0D46_05450	COG3039	Transposase
M0D46_05480	COG0459	protein refolding
M0D46_05490	COG2356	endonuclease I
M0D46_05495	COG1324	tolerance protein
M0D46_05505	COG1505	serine-type exopeptidase activity
M0D46_05510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M0D46_05515	COG0511	ligase activity, forming carbon-carbon bonds
M0D46_05525	COG0439	Biotin carboxylase
M0D46_05570	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M0D46_05585	COG0138	bifunctional purine biosynthesis protein purh
M0D46_05590	COG0151	Belongs to the GarS family
M0D46_05595	COG1289	transmembrane transporter activity
M0D46_05600	COG2814	Major facilitator Superfamily
M0D46_05610	COG2814	Major facilitator Superfamily
M0D46_05625	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M0D46_05640	COG0316	Belongs to the HesB IscA family
M0D46_05695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M0D46_05705	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
M0D46_05720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M0D46_05730	COG0134	indole-3-glycerol-phosphate synthase activity
M0D46_05735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M0D46_05765	COG1597	lipid kinase activity
M0D46_05770	COG0456	acetyltransferase
M0D46_05775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M0D46_05785	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M0D46_05820	COG2111	Na H antiporter
M0D46_05820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M0D46_05825	COG1006	Multisubunit Na H antiporter MnhC subunit
M0D46_05830	COG0651	ATP synthesis coupled electron transport
M0D46_05840	COG2212	antiporter activity
M0D46_05845	COG1320	monovalent cation:proton antiporter activity
M0D46_05865	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M0D46_05885	COG3104	oligopeptide transport
M0D46_05900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M0D46_05925	COG0513	Belongs to the DEAD box helicase family
M0D46_05945	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_05965	COG0702	epimerase
M0D46_05990	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M0D46_05995	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M0D46_06000	COG0297	glycogen (starch) synthase activity
M0D46_06010	COG1649	PFAM Uncharacterised BCR, COG1649
M0D46_06015	COG2354	Protein conserved in bacteria
M0D46_06020	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D46_06025	COG1368	sulfuric ester hydrolase activity
M0D46_06030	COG1511	domain protein
M0D46_06030	COG3264	Mechanosensitive ion channel
M0D46_06105	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M0D46_06185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M0D46_06190	COG1040	competence protein
M0D46_06195	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M0D46_06200	COG0156	8-amino-7-oxononanoate synthase activity
M0D46_06215	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_06240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M0D46_06255	COG0445	tRNA wobble uridine modification
M0D46_06265	COG0657	acetylesterase activity
M0D46_06275	COG1414	Transcriptional regulator
M0D46_06290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M0D46_06295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D46_06305	COG3485	protocatechuate 3,4-dioxygenase
M0D46_06310	COG3485	protocatechuate 3,4-dioxygenase
M0D46_06320	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M0D46_06325	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M0D46_06350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M0D46_06355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M0D46_06410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M0D46_06420	COG0129	dihydroxy-acid dehydratase activity
M0D46_06455	COG1733	regulation of RNA biosynthetic process
M0D46_06460	COG0702	epimerase
M0D46_06490	COG0583	DNA-binding transcription factor activity
M0D46_06495	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M0D46_06550	COG1902	pentaerythritol trinitrate reductase activity
M0D46_06555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M0D46_06560	COG0596	Alpha beta hydrolase
M0D46_06575	COG2814	Major facilitator Superfamily
M0D46_06580	COG0583	DNA-binding transcription factor activity
M0D46_06585	COG0084	hydrolase, TatD family'
M0D46_06605	COG2252	PERMEase
M0D46_06665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M0D46_06685	COG2072	flavoprotein involved in K transport
M0D46_06690	COG2351	hydroxyisourate hydrolase activity
M0D46_06695	COG4807	Protein conserved in bacteria
M0D46_06705	COG1643	Atp-dependent helicase
M0D46_06715	COG1187	pseudouridine synthase activity
M0D46_06730	COG2130	NADP-dependent
M0D46_06735	COG0656	L-ascorbic acid biosynthetic process
M0D46_06755	COG1764	response to oxidative stress
M0D46_06760	COG1846	Transcriptional regulator
M0D46_06765	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M0D46_06775	COG0697	spore germination
M0D46_06785	COG0523	cobalamin synthesis protein
M0D46_06840	COG1960	acyl-CoA dehydrogenase activity
M0D46_06845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M0D46_06850	COG4770	biotin carboxylase activity
M0D46_06880	COG2224	Isocitrate lyase
M0D46_06885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M0D46_06890	COG0583	DNA-binding transcription factor activity
M0D46_06895	COG0475	glutathione-regulated potassium exporter activity
M0D46_06925	COG0681	Belongs to the peptidase S26 family
M0D46_06930	COG0339	signal peptide processing
M0D46_06935	COG1446	asparaginase
M0D46_06955	COG0564	pseudouridine synthase activity
M0D46_06970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D46_06995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D46_07000	COG0318	PFAM AMP-dependent synthetase and ligase
M0D46_07005	COG0727	PFAM Uncharacterised protein family (UPF0153)
M0D46_07010	COG0596	Alpha beta hydrolase
M0D46_07025	COG3177	Filamentation induced by cAMP protein fic
M0D46_07030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D46_07045	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M0D46_07070	COG2205	protein histidine kinase activity
M0D46_07075	COG0028	Belongs to the TPP enzyme family
M0D46_07085	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M0D46_07090	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M0D46_07095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M0D46_07135	COG0183	Belongs to the thiolase family
M0D46_07150	COG2032	superoxide dismutase activity
M0D46_07155	COG2032	superoxide dismutase activity
M0D46_07160	COG2204	response regulator
M0D46_07165	COG3852	Histidine kinase
M0D46_07170	COG0004	ammonium transporteR
M0D46_07175	COG0347	Belongs to the P(II) protein family
M0D46_07180	COG0174	glutamine synthetase
M0D46_07185	COG1968	undecaprenyl-diphosphatase activity
M0D46_07230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D46_07240	COG2062	phosphohistidine phosphatase, SixA
M0D46_07245	COG0489	protein tyrosine kinase activity
M0D46_07265	COG3620	sequence-specific DNA binding
M0D46_07270	COG3550	peptidyl-serine autophosphorylation
M0D46_07275	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
M0D46_07280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M0D46_07295	COG1125	glycine betaine transport
M0D46_07295	COG0517	IMP dehydrogenase activity
M0D46_07310	COG1119	ATPase activity
M0D46_07320	COG1473	amidohydrolase
M0D46_07325	COG1752	Esterase of the alpha-beta hydrolase superfamily
M0D46_07335	COG1522	sequence-specific DNA binding
M0D46_07340	COG3186	Phenylalanine-4-hydroxylase
M0D46_07350	COG2755	lipolytic protein G-D-S-L family
M0D46_07360	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_07365	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M0D46_07370	COG1609	Transcriptional regulator
M0D46_07375	COG3507	Belongs to the glycosyl hydrolase 43 family
M0D46_07390	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M0D46_07400	COG0657	acetylesterase activity
M0D46_07400	COG2755	lipolytic protein G-D-S-L family
M0D46_07425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M0D46_07430	COG0366	Alpha amylase catalytic
M0D46_07435	COG0366	Alpha amylase catalytic
M0D46_07440	COG2831	hemolysin activation secretion protein
M0D46_07445	COG3210	domain, Protein
M0D46_07485	COG3210	domain, Protein
M0D46_07520	COG3210	domain, Protein
M0D46_07620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D46_07630	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M0D46_07635	COG3710	Transcriptional regulator
M0D46_07655	COG2197	response regulator
M0D46_07660	COG4585	Histidine kinase
M0D46_07665	COG1755	Isoprenylcysteine carboxyl methyltransferase
M0D46_07670	COG1304	FMN binding
M0D46_07695	COG1012	belongs to the aldehyde dehydrogenase family
M0D46_07700	COG4772	TonB-dependent receptor
M0D46_07710	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M0D46_07760	COG0714	Associated with various cellular activities
M0D46_07800	COG0477	Major facilitator Superfamily
M0D46_07805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D46_07865	COG3237	CsbD-like
M0D46_07875	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M0D46_07910	COG0625	glutathione transferase activity
M0D46_07920	COG1272	protein, Hemolysin III
M0D46_07925	COG1111	helicase
M0D46_07925	COG1205	dead DEAH box helicase
M0D46_08005	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M0D46_08040	COG1132	(ABC) transporter
M0D46_08070	COG0367	asparagine synthase
M0D46_08090	COG0438	transferase activity, transferring glycosyl groups
M0D46_08090	COG0297	glycogen (starch) synthase activity
M0D46_08095	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M0D46_08115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M0D46_08185	COG0070	glutamate synthase
M0D46_08185	COG0069	glutamate synthase activity
M0D46_08185	COG0067	glutamate synthase
M0D46_08190	COG0493	'glutamate synthase
M0D46_08200	COG1064	alcohol dehydrogenase
M0D46_08205	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D46_08210	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D46_08220	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D46_08230	COG2234	aminopeptidase activity
M0D46_08240	COG4942	peptidase
M0D46_08245	COG0793	Belongs to the peptidase S41A family
M0D46_08250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M0D46_08290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D46_08300	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M0D46_08335	COG0501	Belongs to the peptidase M48B family
M0D46_08345	COG0187	DNA topoisomerase II activity
M0D46_08360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M0D46_08380	COG0726	polysaccharide deacetylase
M0D46_08385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M0D46_08400	COG0584	glycerophosphoryl diester phosphodiesterase
M0D46_08410	COG0861	Integral membrane protein TerC family
M0D46_08415	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M0D46_08430	COG2271	Major facilitator Superfamily
M0D46_08435	COG1929	Belongs to the glycerate kinase type-1 family
M0D46_08440	COG3835	regulator
M0D46_08445	COG3706	GGDEF domain
M0D46_08465	COG3537	Alpha-1,2-mannosidase
M0D46_08470	COG0531	amino acid
M0D46_08495	COG0604	alcohol dehydrogenase
M0D46_08500	COG1322	Protein conserved in bacteria
M0D46_08510	COG0386	Belongs to the glutathione peroxidase family
M0D46_08520	COG2853	Lipoprotein
M0D46_08540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M0D46_08545	COG1127	ABC transporter
M0D46_08550	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M0D46_08555	COG1074	ATP-dependent DNA helicase activity
M0D46_08560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M0D46_08595	COG0564	pseudouridine synthase activity
M0D46_08640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D46_08660	COG0477	Major facilitator Superfamily
M0D46_08665	COG1289	transmembrane transporter activity
M0D46_08675	COG1566	PFAM secretion protein HlyD family protein
M0D46_08690	COG0302	gtp cyclohydrolase
M0D46_08710	COG0730	response to heat
M0D46_08715	COG3012	SEC-C Motif Domain Protein
M0D46_08725	COG0676	glucose-6-phosphate 1-epimerase activity
M0D46_08745	COG3135	benzoate transporter
M0D46_08775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M0D46_08785	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M0D46_08795	COG1435	thymidine kinase activity
M0D46_08800	COG0210	DNA helicase
M0D46_08815	COG3132	Protein of unknown function, DUF480
M0D46_08820	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M0D46_08825	COG0284	orotidine-5'-phosphate decarboxylase activity
M0D46_08855	COG2937	Belongs to the GPAT DAPAT family
M0D46_08910	COG2211	Major facilitator Superfamily
M0D46_08925	COG3693	PFAM glycoside hydrolase, family 10
M0D46_08945	COG1904	glucuronate isomerase
M0D46_08965	COG3386	PFAM SMP-30 Gluconolaconase
M0D46_08990	COG0246	Mannitol dehydrogenase
M0D46_08995	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D46_09005	COG4948	Mandelate Racemase Muconate Lactonizing
M0D46_09015	COG3661	Belongs to the glycosyl hydrolase 67 family
M0D46_09035	COG2974	May be involved in recombination
M0D46_09050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M0D46_09060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M0D46_09065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M0D46_09070	COG0805	protein transport
M0D46_09080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M0D46_09080	COG0519	Catalyzes the synthesis of GMP from XMP
M0D46_09090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M0D46_09095	COG0752	glycyl-tRNA synthetase alpha subunit
M0D46_09105	COG0457	Tetratricopeptide repeat
M0D46_09110	COG4771	TonB-dependent receptor
M0D46_09115	COG0729	surface antigen
M0D46_09120	COG2911	Protein conserved in bacteria
M0D46_09140	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D46_09145	COG3265	gluconokinase activity
M0D46_09150	COG2211	Major facilitator Superfamily
M0D46_09155	COG3459	Glycosyltransferase 36 associated
M0D46_09165	COG2205	protein histidine kinase activity
M0D46_09185	COG1414	Transcriptional regulator
M0D46_09190	COG0738	Major facilitator superfamily
M0D46_09195	COG3254	rhamnose metabolic process
M0D46_09200	COG4948	Mandelate Racemase Muconate Lactonizing
M0D46_09205	COG0179	Fumarylacetoacetate (FAA) hydrolase
M0D46_09210	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_09260	COG3162	membrane
M0D46_09265	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M0D46_09270	COG1940	carbohydrate kinase activity
M0D46_09290	COG2091	lysine biosynthetic process via aminoadipic acid
M0D46_09300	COG3540	Alkaline phosphatase
M0D46_09305	COG0357	Ribosomal RNA small subunit methyltransferase G
M0D46_09325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D46_09350	COG2159	amidohydrolase
M0D46_09360	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M0D46_09365	COG0583	DNA-binding transcription factor activity
M0D46_09370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D46_09385	COG0210	DNA helicase
M0D46_09475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M0D46_09475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M0D46_09485	COG0408	coproporphyrinogen oxidase activity
M0D46_09500	COG1506	peptidase
M0D46_09500	COG4946	Tricorn protease homolog
M0D46_09500	COG0823	Involved in the tonB-independent uptake of proteins
M0D46_09515	COG0644	oxidoreductase
M0D46_09520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M0D46_09560	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_09580	COG0463	Glycosyl transferase, family 2
M0D46_09590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M0D46_09595	COG3100	YcgL domain-containing protein
M0D46_09610	COG3387	PFAM Glycoside hydrolase 15-related
M0D46_09615	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M0D46_09635	COG2239	Acts as a magnesium transporter
M0D46_09645	COG0045	succinate-CoA ligase (ADP-forming) activity
M0D46_09645	COG1042	CoA-binding domain protein
M0D46_09645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M0D46_09655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M0D46_09660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M0D46_09685	COG1607	acyl-coa hydrolase
M0D46_09700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M0D46_09705	COG0842	Transport permease protein
M0D46_09710	COG1131	(ABC) transporter
M0D46_09715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M0D46_09735	COG1476	TRANSCRIPTIONal
M0D46_09745	COG4555	ABC transporter
M0D46_09780	COG0625	glutathione transferase activity
M0D46_09865	COG1199	ATP-dependent helicase activity
M0D46_09895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M0D46_09940	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M0D46_09955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M0D46_09995	COG3237	CsbD-like
M0D46_10000	COG0180	Tryptophanyl-tRNA synthetase
M0D46_10025	COG0697	spore germination
M0D46_10050	COG1136	(ABC) transporter
M0D46_10055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D46_10060	COG4585	Histidine kinase
M0D46_10065	COG2197	response regulator
M0D46_10080	COG0753	catalase activity
M0D46_10085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M0D46_10090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D46_10095	COG0628	permease
M0D46_10115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M0D46_10125	COG1090	epimerase
M0D46_10165	COG1690	Belongs to the RtcB family
M0D46_10195	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M0D46_10210	COG0606	chelatase, subunit chli
M0D46_10225	COG3291	Pkd domain containing protein
M0D46_10225	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M0D46_10245	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M0D46_10250	COG1166	arginine decarboxylase activity
M0D46_10255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M0D46_10265	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M0D46_10265	COG2755	lipolytic protein G-D-S-L family
M0D46_10270	COG4221	oxidoreductase activity
M0D46_10285	COG0018	arginyl-trna synthetase
M0D46_10290	COG2003	Belongs to the UPF0758 family
M0D46_10295	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M0D46_10320	COG0463	Glycosyl transferase, family 2
M0D46_10335	COG1475	DNA binding
M0D46_10340	COG1192	Involved in chromosome partitioning
M0D46_10355	COG0708	Exodeoxyribonuclease III
M0D46_10360	COG2223	nitrite transmembrane transporter activity
M0D46_10375	COG0739	heme binding
M0D46_10420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M0D46_10435	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M0D46_10485	COG0358	DNA primase activity
M0D46_10490	COG1295	ribonuclease BN
M0D46_10500	COG1610	YqeY-like protein
M0D46_10510	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M0D46_10515	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M0D46_10525	COG2133	pyrroloquinoline quinone binding
M0D46_10530	COG4682	membrane
M0D46_10545	COG0531	amino acid
M0D46_10555	COG4948	Mandelate Racemase Muconate Lactonizing
M0D46_10565	COG3023	N-Acetylmuramoyl-L-alanine amidase
M0D46_10570	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
M0D46_10605	COG5383	Protein conserved in bacteria
M0D46_10630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D46_10635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D46_10640	COG1473	amidohydrolase
M0D46_10645	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M0D46_10645	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M0D46_10650	COG1652	LysM domain
M0D46_10675	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
M0D46_10690	COG3118	belongs to the thioredoxin family
M0D46_10700	COG2884	Cell division ATP-binding protein ftsE
M0D46_10705	COG2177	Part of the ABC transporter FtsEX involved in
M0D46_10710	COG2201	protein-glutamate methylesterase activity
M0D46_10715	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M0D46_10720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M0D46_10725	COG2860	membrane
M0D46_10730	COG1252	NADH dehydrogenase
M0D46_10745	COG0625	glutathione transferase activity
M0D46_10750	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M0D46_10770	COG0534	Mate efflux family protein
M0D46_10775	COG0616	signal peptide processing
M0D46_10785	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_10800	COG0009	L-threonylcarbamoyladenylate synthase
M0D46_10805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M0D46_10805	COG1754	DNA topoisomerase type I activity
M0D46_10825	COG0758	DNA mediated transformation
M0D46_10830	COG1652	LysM domain
M0D46_10835	COG0242	peptide deformylase activity
M0D46_10840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M0D46_10845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M0D46_10845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M0D46_10890	COG1560	Kdo2-lipid A biosynthetic process
M0D46_10895	COG1490	D-aminoacyl-tRNA deacylase activity
M0D46_10900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M0D46_10970	COG1999	signal sequence binding
M0D46_10985	COG0024	Methionine aminopeptidase
M0D46_10995	COG0038	chloride channel
M0D46_11000	COG0659	secondary active sulfate transmembrane transporter activity
M0D46_11045	COG1131	(ABC) transporter
M0D46_11105	COG1063	alcohol dehydrogenase
M0D46_11115	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_11130	COG1294	oxidase, subunit
M0D46_11135	COG1271	oxidase subunit
M0D46_11150	COG3546	catalase activity
M0D46_11155	COG3685	Protein conserved in bacteria
M0D46_11170	COG2972	Histidine kinase
M0D46_11185	COG0531	amino acid
M0D46_11200	COG3590	peptidase
M0D46_11210	COG0667	Aldo Keto reductase
M0D46_11220	COG0583	DNA-binding transcription factor activity
M0D46_11230	COG3384	dioxygenase
M0D46_11240	COG1573	uracil-dna glycosylase
M0D46_11245	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M0D46_11255	COG0025	NhaP-type Na H and K H
M0D46_11260	COG1131	(ABC) transporter
M0D46_11265	COG0842	Transport permease protein
M0D46_11295	COG1404	Belongs to the peptidase S8 family
M0D46_11310	COG0745	RESPONSE REGULATOR receiver
M0D46_11355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D46_11360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M0D46_11380	COG2202	Pas domain
M0D46_11380	COG2205	protein histidine kinase activity
M0D46_11400	COG2813	Specifically methylates the guanine in position
M0D46_11405	COG1187	pseudouridine synthase activity
M0D46_11410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D46_11430	COG2205	protein histidine kinase activity
M0D46_11430	COG3850	Histidine kinase
M0D46_11430	COG4999	Histidine kinase
M0D46_11430	COG3437	response regulator, receiver
M0D46_11445	COG0697	spore germination
M0D46_11450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M0D46_11455	COG2011	ABC-type metal ion transport system permease component
M0D46_11495	COG0508	dehydrogenase complex catalyzes the overall conversion of
M0D46_11505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M0D46_11525	COG0356	it plays a direct role in the translocation of protons across the membrane
M0D46_11535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M0D46_11540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M0D46_11545	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M0D46_11550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M0D46_11575	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M0D46_11595	COG0577	efflux transmembrane transporter activity
M0D46_11595	COG1136	(ABC) transporter
M0D46_11600	COG1136	(ABC) transporter
M0D46_11600	COG0577	efflux transmembrane transporter activity
M0D46_11605	COG0577	efflux transmembrane transporter activity
M0D46_11605	COG1136	(ABC) transporter
M0D46_11610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D46_11615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M0D46_11665	COG0339	signal peptide processing
M0D46_11680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M0D46_11685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M0D46_11700	COG1956	GAF domain-containing protein
M0D46_11705	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M0D46_11715	COG0720	synthase
M0D46_11720	COG0513	Belongs to the DEAD box helicase family
M0D46_11730	COG0625	glutathione transferase activity
M0D46_11760	COG0626	cystathionine gamma-synthase activity
M0D46_11775	COG0110	maltose O-acetyltransferase activity
M0D46_11780	COG1216	Glycosyl transferase, family 2
M0D46_11780	COG0438	transferase activity, transferring glycosyl groups
M0D46_11785	COG3754	Rhamnan synthesis protein F
M0D46_11795	COG2226	methyltransferase
M0D46_11815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D46_11825	COG0300	oxidoreductase activity
M0D46_11830	COG0277	FAD linked oxidase domain protein
M0D46_11835	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M0D46_11835	COG0546	phosphoglycolate phosphatase activity
M0D46_11850	COG2086	electron transfer activity
M0D46_11875	COG0662	Cupin 2, conserved barrel domain protein
M0D46_11875	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M0D46_11880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M0D46_11915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M0D46_11915	COG3218	ABC-type transport auxiliary lipoprotein component
M0D46_11920	COG1127	ABC transporter
M0D46_11925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M0D46_11950	COG1183	phosphatidylcholine synthase activity
M0D46_11970	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M0D46_11980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M0D46_11990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M0D46_12005	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M0D46_12015	COG2205	protein histidine kinase activity
M0D46_12040	COG3791	Glutathione-dependent formaldehyde-activating
M0D46_12070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M0D46_12075	COG0697	spore germination
M0D46_12085	COG1307	EDD domain protein, DegV family
M0D46_12120	COG0402	S-adenosylhomocysteine deaminase activity
M0D46_12125	COG3964	amidohydrolase
M0D46_12140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M0D46_12160	COG0436	Aminotransferase
M0D46_12165	COG1162	GTPase activity
M0D46_12195	COG2211	Major facilitator Superfamily
M0D46_12200	COG1609	Transcriptional regulator
M0D46_12205	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_12210	COG2851	Citrate transporter
M0D46_12225	COG0642	Histidine kinase
M0D46_12235	COG2197	response regulator
M0D46_12255	COG0667	Aldo Keto reductase
M0D46_12260	COG0583	DNA-binding transcription factor activity
M0D46_12275	COG4191	Histidine kinase
M0D46_12290	COG1301	dicarboxylic acid transport
M0D46_12295	COG0280	phosphate acetyltransferase
M0D46_12295	COG0281	malic enzyme
M0D46_12385	COG1560	Kdo2-lipid A biosynthetic process
M0D46_12390	COG1519	Transferase
M0D46_12395	COG1538	Outer membrane efflux protein
M0D46_12400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M0D46_12420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M0D46_12425	COG0066	3-isopropylmalate dehydratase activity
M0D46_12435	COG0473	3-isopropylmalate dehydrogenase activity
M0D46_12440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M0D46_12460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M0D46_12465	COG0405	Gamma-glutamyltransferase
M0D46_12470	COG0840	transmembrane signaling receptor activity
M0D46_12475	COG0823	Involved in the tonB-independent uptake of proteins
M0D46_12475	COG1506	peptidase
M0D46_12475	COG4946	Tricorn protease homolog
M0D46_12480	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M0D46_12485	COG3710	Transcriptional regulator
M0D46_12505	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M0D46_12515	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
M0D46_12545	COG0563	adenylate kinase activity
M0D46_12550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M0D46_12560	COG3781	membrane
M0D46_12565	COG0671	phosphoesterase, PA-phosphatase related
M0D46_12575	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_12590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M0D46_12620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D46_12625	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M0D46_12640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M0D46_12655	COG0352	thiamine-phosphate diphosphorylase activity
M0D46_12660	COG1773	rubredoxin
M0D46_12665	COG2912	Transglutaminase-like superfamily
M0D46_12685	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M0D46_12710	COG0006	proline dipeptidase activity
M0D46_12720	COG0006	proline dipeptidase activity
M0D46_12735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M0D46_12740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M0D46_12750	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M0D46_12755	COG1561	YicC-like family, N-terminal region
M0D46_12770	COG1070	Carbohydrate kinase
M0D46_12775	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_12790	COG1175	transmembrane transport
M0D46_12795	COG3659	wide pore channel activity
M0D46_12805	COG2390	Transcriptional regulator
M0D46_12810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D46_12815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M0D46_12820	COG0583	DNA-binding transcription factor activity
M0D46_12835	COG2271	Major facilitator Superfamily
M0D46_12850	COG2721	sulfolactate sulfo-lyase activity
M0D46_12860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M0D46_12890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M0D46_12920	COG0714	Associated with various cellular activities
M0D46_12940	COG2304	oxidoreductase activity
M0D46_12950	COG1301	dicarboxylic acid transport
M0D46_12960	COG4773	Receptor
M0D46_12965	COG0583	DNA-binding transcription factor activity
M0D46_12970	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_12975	COG0739	heme binding
M0D46_12980	COG1376	ErfK ybiS ycfS ynhG family protein
M0D46_13015	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_13030	COG0642	Histidine kinase
M0D46_13050	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M0D46_13055	COG4149	molybdate abc transporter
M0D46_13060	COG0725	ABC transporter, periplasmic molybdate-binding protein
M0D46_13065	COG3453	Protein conserved in bacteria
M0D46_13065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M0D46_13075	COG3047	cAMP biosynthetic process
M0D46_13085	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M0D46_13115	COG0469	pyruvate kinase activity
M0D46_13120	COG3588	fructose-bisphosphate aldolase
M0D46_13125	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M0D46_13150	COG0583	DNA-binding transcription factor activity
M0D46_13160	COG2198	Histidine kinase
M0D46_13160	COG2205	protein histidine kinase activity
M0D46_13160	COG0784	Response regulator, receiver
M0D46_13180	COG0175	sulfate reduction
M0D46_13185	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M0D46_13190	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M0D46_13195	COG0175	sulfate reduction
M0D46_13200	COG0529	Catalyzes the synthesis of activated sulfate
M0D46_13200	COG2895	sulfate adenylyltransferase (ATP) activity
M0D46_13210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D46_13225	COG0308	aminopeptidase N
M0D46_13235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M0D46_13245	COG4948	Mandelate Racemase Muconate Lactonizing
M0D46_13250	COG3250	beta-galactosidase activity
M0D46_13270	COG1609	Transcriptional regulator
M0D46_13280	COG1970	mechanosensitive ion channel activity
M0D46_13300	COG3273	potassium ion transport
M0D46_13300	COG0471	metal ion transport
M0D46_13310	COG2022	thiamine diphosphate biosynthetic process
M0D46_13395	COG2003	Belongs to the UPF0758 family
M0D46_13430	COG0084	hydrolase, TatD family'
M0D46_13495	COG0745	RESPONSE REGULATOR receiver
M0D46_13525	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M0D46_13535	COG4969	Belongs to the N-Me-Phe pilin family
M0D46_13540	COG2194	sulfuric ester hydrolase activity
M0D46_13555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M0D46_13575	COG0045	succinate-CoA ligase (ADP-forming) activity
M0D46_13595	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M0D46_13595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M0D46_13600	COG0537	adenosine 5'-monophosphoramidase activity
M0D46_13605	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D46_13610	COG0564	pseudouridine synthase activity
M0D46_13625	COG3011	Protein conserved in bacteria
M0D46_13630	COG0840	transmembrane signaling receptor activity
M0D46_13645	COG3387	PFAM Glycoside hydrolase 15-related
M0D46_13650	COG1877	trehalose-phosphatase activity
M0D46_13700	COG0542	response to heat
M0D46_13710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D46_13735	COG4206	TonB-dependent receptor
M0D46_13760	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M0D46_13770	COG1492	cobalamin metabolic process
M0D46_13780	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M0D46_13810	COG0019	diaminopimelate decarboxylase activity
M0D46_13825	COG4264	IucA IucC family
M0D46_13835	COG4772	TonB-dependent receptor
M0D46_13860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M0D46_13860	COG4651	solute:proton antiporter activity
M0D46_13890	COG0488	(ABC) transporter
M0D46_13930	COG0477	Major facilitator Superfamily
M0D46_13945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M0D46_13965	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M0D46_13975	COG3158	transport of potassium into the cell
M0D46_13985	COG2255	four-way junction helicase activity
M0D46_13990	COG0824	Thioesterase
M0D46_14010	COG0823	Involved in the tonB-independent uptake of proteins
M0D46_14015	COG2885	chlorophyll binding
M0D46_14025	COG0602	queuosine metabolic process
M0D46_14035	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M0D46_14065	COG0840	transmembrane signaling receptor activity
M0D46_14075	COG1187	pseudouridine synthase activity
M0D46_14095	COG0514	ATP-dependent DNA helicase (RecQ)
M0D46_14100	COG0783	Belongs to the Dps family
M0D46_14105	COG1643	Atp-dependent helicase
M0D46_14145	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
M0D46_14160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M0D46_14170	COG1215	transferase activity, transferring glycosyl groups
M0D46_14175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M0D46_14185	COG1199	ATP-dependent helicase activity
M0D46_14195	COG1397	ADP-ribosylglycohydrolase
M0D46_14205	COG0189	ligase activity
M0D46_14220	COG0835	chemotaxis
M0D46_14225	COG0840	transmembrane signaling receptor activity
M0D46_14230	COG2198	Histidine kinase
M0D46_14230	COG0784	Response regulator, receiver
M0D46_14230	COG0643	Histidine kinase
M0D46_14255	COG1595	DNA-templated transcription, initiation
M0D46_14265	COG1446	asparaginase
M0D46_14270	COG3142	Participates in the control of copper homeostasis
M0D46_14305	COG3537	Alpha-1,2-mannosidase
M0D46_14315	COG1486	melibiose metabolic process
M0D46_14320	COG0531	amino acid
M0D46_14335	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D46_14345	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M0D46_14355	COG1388	LysM domain
M0D46_14355	COG3858	chitin binding
M0D46_14370	COG0837	glucose binding
M0D46_14375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M0D46_14385	COG0494	nUDIX hydrolase
M0D46_14395	COG3956	TIGRFAM MazG family protein
M0D46_14400	COG1742	UPF0060 membrane protein
M0D46_14405	COG0330	HflC and HflK could
M0D46_14415	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M0D46_14420	COG0509	glycine decarboxylation via glycine cleavage system
M0D46_14445	COG1960	acyl-CoA dehydrogenase activity
M0D46_14455	COG1309	transcriptional regulator
M0D46_14460	COG4206	TonB-dependent receptor
M0D46_14470	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M0D46_14475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M0D46_14480	COG0463	Glycosyl transferase, family 2
M0D46_14485	COG0516	GMP reductase activity
M0D46_14485	COG0517	IMP dehydrogenase activity
M0D46_14490	COG2982	Protein involved in outer membrane biogenesis
M0D46_14495	COG1272	protein, Hemolysin III
M0D46_14500	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M0D46_14505	COG0739	heme binding
M0D46_14510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D46_14515	COG0626	cystathionine gamma-synthase activity
M0D46_14520	COG0460	homoserine dehydrogenase
M0D46_14520	COG0527	aspartate kinase activity
M0D46_14530	COG1760	l-serine dehydratase
M0D46_14550	COG2353	YceI-like domain
M0D46_14555	COG0784	Response regulator, receiver
M0D46_14555	COG2205	protein histidine kinase activity
M0D46_14555	COG2198	Histidine kinase
M0D46_14560	COG0784	Response regulator, receiver
M0D46_14560	COG5002	protein histidine kinase activity
M0D46_14575	COG0477	Major facilitator Superfamily
M0D46_14580	COG2204	response regulator
M0D46_14650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M0D46_14660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M0D46_14665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M0D46_14680	COG1842	Phage shock protein A
M0D46_14705	COG0754	glutathionylspermidine amidase activity
M0D46_14710	COG2814	Major facilitator Superfamily
M0D46_14770	COG0531	amino acid
M0D46_14790	COG1113	amino acid transport
M0D46_14800	COG1271	oxidase subunit
M0D46_14805	COG1294	oxidase, subunit
M0D46_14815	COG2239	Acts as a magnesium transporter
M0D46_14820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M0D46_14825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D46_14835	COG1660	Displays ATPase and GTPase activities
M0D46_14845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D46_14860	COG1137	ATPase activity
M0D46_14865	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M0D46_14875	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M0D46_14885	COG0271	Belongs to the BolA IbaG family
M0D46_14890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M0D46_14910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M0D46_14920	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M0D46_14930	COG0628	permease
M0D46_14945	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M0D46_14950	COG3178	'Phosphotransferase
M0D46_14960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D46_14965	COG1555	photosystem II stabilization
M0D46_14980	COG1477	protein flavinylation
M0D46_15010	COG3128	pkhd-type hydroxylase
M0D46_15015	COG4774	siderophore transport
M0D46_15020	COG2146	nitrite reductase [NAD(P)H] activity
M0D46_15030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M0D46_15035	COG0719	Fe-S assembly protein
M0D46_15040	COG0396	ATPase activity
M0D46_15045	COG0719	Fe-S assembly protein
M0D46_15060	COG0693	protein deglycase activity
M0D46_15095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M0D46_15120	COG0519	Catalyzes the synthesis of GMP from XMP
M0D46_15125	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M0D46_15130	COG1678	Uncharacterized ACR, COG1678
M0D46_15135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M0D46_15140	COG0540	Belongs to the ATCase OTCase family
M0D46_15145	COG1764	response to oxidative stress
M0D46_15155	COG0384	phenazine biosynthesis protein PhzF
M0D46_15160	COG0384	phenazine biosynthesis protein PhzF
M0D46_15165	COG0527	aspartate kinase activity
M0D46_15190	COG0142	geranyltranstransferase activity
M0D46_15195	COG0629	single-stranded DNA binding
M0D46_15240	COG0673	inositol 2-dehydrogenase activity
M0D46_15245	COG2211	Major facilitator Superfamily
M0D46_15255	COG1609	Transcriptional regulator
M0D46_15260	COG3706	GGDEF domain
M0D46_15260	COG2203	Gaf domain
M0D46_15260	COG4251	negative regulation of phosphorylation
M0D46_15260	COG5001	Diguanylate cyclase
M0D46_15270	COG2080	2 iron, 2 sulfur cluster binding
M0D46_15275	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M0D46_15280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M0D46_15285	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M0D46_15320	COG2879	small protein
M0D46_15325	COG1966	Carbon starvation protein
M0D46_15330	COG1741	Belongs to the pirin family
M0D46_15345	COG1741	Belongs to the pirin family
M0D46_15350	COG1515	deoxyribonuclease V activity
M0D46_15355	COG0588	phosphoglycerate mutase activity
M0D46_15365	COG3590	peptidase
M0D46_15370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D46_15380	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M0D46_15385	COG2200	EAL domain
M0D46_15385	COG2202	Pas domain
M0D46_15385	COG2199	diguanylate cyclase activity
M0D46_15390	COG0835	chemotaxis
M0D46_15395	COG0840	transmembrane signaling receptor activity
M0D46_15400	COG0643	Histidine kinase
M0D46_15400	COG2198	Histidine kinase
M0D46_15410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M0D46_15420	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M0D46_15425	COG0745	RESPONSE REGULATOR receiver
M0D46_15435	COG2205	protein histidine kinase activity
M0D46_15445	COG4452	Inner membrane protein CreD
M0D46_15470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D46_15475	COG0735	belongs to the Fur family
M0D46_15490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D46_15500	COG1309	transcriptional regulator
M0D46_15510	COG2207	Transcriptional regulator
M0D46_15525	COG0583	DNA-binding transcription factor activity
M0D46_15530	COG2814	Major facilitator Superfamily
M0D46_15535	COG0667	Aldo Keto reductase
M0D46_15640	COG5001	Diguanylate cyclase
M0D46_15640	COG5002	protein histidine kinase activity
M0D46_15645	COG1187	pseudouridine synthase activity
M0D46_15670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M0D46_15680	COG0475	glutathione-regulated potassium exporter activity
M0D46_15685	COG5000	phosphorelay sensor kinase activity
M0D46_15685	COG5002	protein histidine kinase activity
M0D46_15690	COG0745	RESPONSE REGULATOR receiver
M0D46_15700	COG3713	MltA-interacting MipA family protein
M0D46_15720	COG1132	(ABC) transporter
M0D46_15800	COG3118	belongs to the thioredoxin family
M0D46_15810	COG0495	leucyl-tRNA aminoacylation
M0D46_15825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M0D46_15840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M0D46_15860	COG2968	Membrane
M0D46_15875	COG3164	Protein of unknown function
M0D46_15885	COG0312	modulator of DNA gyrase
M0D46_15890	COG3028	Belongs to the UPF0307 family
M0D46_15895	COG0312	modulator of DNA gyrase
M0D46_15905	COG4104	PAAR repeat-containing protein
M0D46_15910	COG0142	geranyltranstransferase activity
M0D46_15915	COG1722	exodeoxyribonuclease VII activity
M0D46_15920	COG0037	tRNA processing
M0D46_15925	COG1785	Belongs to the alkaline phosphatase family
M0D46_15930	COG1301	dicarboxylic acid transport
M0D46_15935	COG2226	methyltransferase
M0D46_15950	COG0791	NLP P60 protein
M0D46_15955	COG0791	NLP P60 protein
M0D46_15960	COG1047	Peptidyl-prolyl cis-trans
M0D46_15965	COG2311	Membrane
M0D46_15970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D46_15975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M0D46_15995	COG3590	peptidase
M0D46_16000	COG3590	peptidase
M0D46_16015	COG0489	protein tyrosine kinase activity
M0D46_16020	COG0717	Belongs to the dCTP deaminase family
M0D46_16050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M0D46_16055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D46_16070	COG0494	nUDIX hydrolase
M0D46_16080	COG0433	COG0433 Predicted ATPase
M0D46_16090	COG0688	phosphatidylethanolamine metabolic process
M0D46_16100	COG2890	protein-(glutamine-N5) methyltransferase activity
M0D46_16105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M0D46_16115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M0D46_16135	COG0101	tRNA pseudouridine synthase activity
M0D46_16140	COG0135	phosphoribosylanthranilate isomerase activity
M0D46_16155	COG0133	tryptophan synthase activity
M0D46_16170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M0D46_16175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M0D46_16210	COG0149	triose-phosphate isomerase activity
M0D46_16225	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M0D46_16235	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M0D46_16240	COG0649	NAD binding
M0D46_16245	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M0D46_16250	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M0D46_16260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M0D46_16270	COG0839	Belongs to the complex I subunit 6 family
M0D46_16290	COG1007	ATP synthesis coupled electron transport
M0D46_16300	COG0779	Required for maturation of 30S ribosomal subunits
M0D46_16305	COG0195	Participates in both transcription termination and antitermination
M0D46_16315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M0D46_16325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M0D46_16330	COG1185	polyribonucleotide nucleotidyltransferase activity
M0D46_16365	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M0D46_16375	COG2095	MarC family integral membrane protein
M0D46_16385	COG1611	Belongs to the LOG family
M0D46_16430	COG0556	nucleotide-excision repair
M0D46_16445	COG3505	Type IV secretory pathway VirD4
M0D46_16485	COG3702	type iv secretory pathway
M0D46_16570	COG0366	Alpha amylase catalytic
M0D46_16605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M0D46_16610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M0D46_16625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M0D46_16630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D46_16630	COG0072	phenylalanine-tRNA ligase activity
M0D46_16680	COG0438	transferase activity, transferring glycosyl groups
M0D46_16685	COG0438	transferase activity, transferring glycosyl groups
M0D46_16695	COG0438	transferase activity, transferring glycosyl groups
M0D46_16720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D46_16730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D46_16750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M0D46_16760	COG1960	acyl-CoA dehydrogenase activity
M0D46_16770	COG3040	lipid binding
M0D46_16790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M0D46_16800	COG4191	Histidine kinase
M0D46_16800	COG0784	Response regulator, receiver
M0D46_16810	COG1194	a g-specific adenine glycosylase
M0D46_16815	COG0552	protein localization to endoplasmic reticulum
M0D46_16825	COG3938	Belongs to the proline racemase family
M0D46_16830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D46_16845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M0D46_16855	COG0006	proline dipeptidase activity
M0D46_16870	COG0531	amino acid
M0D46_16915	COG1506	peptidase
M0D46_16915	COG0823	Involved in the tonB-independent uptake of proteins
M0D46_16935	COG0326	Molecular chaperone. Has ATPase activity
M0D46_16940	COG0742	ribosomal rna small subunit methyltransferase
M0D46_16945	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M0D46_16955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M0D46_16960	COG0405	Gamma-glutamyltransferase
M0D46_16970	COG3291	Pkd domain containing protein
M0D46_16975	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M0D46_17000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M0D46_17015	COG0343	queuine tRNA-ribosyltransferase activity
M0D46_17020	COG1862	Preprotein translocase
M0D46_17030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M0D46_17070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M0D46_17070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M0D46_17075	COG1105	Belongs to the carbohydrate kinase PfkB family
M0D46_17080	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D46_17080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M0D46_17085	COG1609	Transcriptional regulator
M0D46_17090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D46_17105	COG2902	Dehydrogenase
M0D46_17150	COG0477	Major facilitator Superfamily
M0D46_17160	COG5002	protein histidine kinase activity
M0D46_17160	COG2205	protein histidine kinase activity
M0D46_17160	COG0784	Response regulator, receiver
M0D46_17165	COG2733	membrane
M0D46_17175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M0D46_17180	COG2223	nitrite transmembrane transporter activity
M0D46_17185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M0D46_17190	COG0243	molybdopterin cofactor binding
M0D46_17200	COG0477	Major facilitator Superfamily
M0D46_17210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D46_17215	COG0174	glutamine synthetase
M0D46_17220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M0D46_17235	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M0D46_17255	COG3842	ATPase activity
M0D46_17260	COG1176	ABC-type spermidine putrescine transport system, permease component I
M0D46_17265	COG1177	transmembrane transport
M0D46_17275	COG1012	belongs to the aldehyde dehydrogenase family
M0D46_17290	COG4535	Mg2 and Co2 transporter CorC
M0D46_17310	COG1702	phosphate starvation-inducible protein PhoH
M0D46_17330	COG0741	lytic transglycosylase activity
M0D46_17335	COG0723	plastoquinol--plastocyanin reductase activity
M0D46_17340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M0D46_17345	COG2857	Cytochrome c1
M0D46_17350	COG0625	glutathione transferase activity
M0D46_17355	COG2969	positive regulation of protein catabolic process
M0D46_17375	COG1201	RNA secondary structure unwinding
M0D46_17385	COG0835	chemotaxis
M0D46_17430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M0D46_17440	COG1570	exodeoxyribonuclease VII activity
M0D46_17450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M0D46_17450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M0D46_17455	COG0802	atpase or kinase
M0D46_17460	COG0860	N-Acetylmuramoyl-L-alanine amidase
M0D46_17465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M0D46_17485	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_17490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D46_17495	COG0501	Belongs to the peptidase M48B family
M0D46_17505	COG2081	HI0933 family
M0D46_17510	COG4681	YaeQ
M0D46_17515	COG1671	Belongs to the UPF0178 family
M0D46_17525	COG0625	glutathione transferase activity
M0D46_17535	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M0D46_17540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M0D46_17545	COG0513	Belongs to the DEAD box helicase family
M0D46_17550	COG0488	(ABC) transporter
M0D46_17565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M0D46_17570	COG0483	inositol monophosphate 1-phosphatase activity
M0D46_17585	COG5001	Diguanylate cyclase
M0D46_17585	COG3300	MHYT domain
M0D46_17590	COG1509	lysine 2,3-aminomutase activity
M0D46_17605	COG0402	S-adenosylhomocysteine deaminase activity
M0D46_17610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M0D46_17630	COG4677	pectinesterase activity
M0D46_17670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M0D46_17695	COG2166	iron-sulfur cluster assembly
M0D46_17700	COG0215	cysteine-tRNA ligase activity
M0D46_17710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M0D46_17715	COG0137	argininosuccinate synthase activity
M0D46_17720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D46_17725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M0D46_17740	COG0165	Argininosuccinate lyase
M0D46_17800	COG1294	oxidase, subunit
M0D46_17810	COG4988	ABC transporter
M0D46_17815	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M0D46_17825	COG1278	Cold shock
M0D46_17830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D46_17855	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M0D46_17875	COG4133	protoheme IX ABC transporter activity
M0D46_17880	COG0436	Aminotransferase
M0D46_17900	COG1187	pseudouridine synthase activity
M0D46_17905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M0D46_17910	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M0D46_17915	COG2350	Protein conserved in bacteria
M0D46_17945	COG1175	transmembrane transport
M0D46_17950	COG0395	ABC-type sugar transport system, permease component
M0D46_17975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M0D46_17980	COG2957	Belongs to the agmatine deiminase family
M0D46_17995	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M0D46_18000	COG0539	negative regulation of cytoplasmic translation
M0D46_18005	COG0776	regulation of translation
M0D46_18015	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M0D46_18020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M0D46_18030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M0D46_18035	COG0475	glutathione-regulated potassium exporter activity
M0D46_18035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M0D46_18045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M0D46_18060	COG3002	Belongs to the UPF0753 family
M0D46_18065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M0D46_18070	COG0583	DNA-binding transcription factor activity
M0D46_18075	COG0583	DNA-binding transcription factor activity
M0D46_18090	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_18110	COG2197	response regulator
M0D46_18125	COG1335	isochorismatase
M0D46_18140	COG2814	Major facilitator Superfamily
M0D46_18155	COG1914	H( )-stimulated, divalent metal cation uptake system
M0D46_18165	COG0590	tRNA wobble adenosine to inosine editing
M0D46_18175	COG0668	transmembrane transport
M0D46_18185	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M0D46_18200	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_18205	COG1183	phosphatidylcholine synthase activity
M0D46_18215	COG3243	poly(R)-hydroxyalkanoic acid synthase
M0D46_18230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D46_18230	COG0723	plastoquinol--plastocyanin reductase activity
M0D46_18240	COG2183	response to ionizing radiation
M0D46_18245	COG0784	Response regulator, receiver
M0D46_18245	COG2205	protein histidine kinase activity
M0D46_18245	COG5002	protein histidine kinase activity
M0D46_18310	COG0800	Aldolase
M0D46_18315	COG0129	dihydroxy-acid dehydratase activity
M0D46_18320	COG0363	glucosamine-6-phosphate deaminase activity
M0D46_18325	COG0837	glucose binding
M0D46_18330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M0D46_18355	COG2009	succinate dehydrogenase
M0D46_18360	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M0D46_18375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M0D46_18380	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M0D46_18390	COG4591	ABC-type transport system involved in lipoprotein release permease component
M0D46_18410	COG0811	peptide transport
M0D46_18420	COG1132	(ABC) transporter
M0D46_18425	COG1663	tetraacyldisaccharide 4'-kinase activity
M0D46_18430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M0D46_18435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M0D46_18445	COG0322	excinuclease ABC activity
M0D46_18495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M0D46_18515	COG1054	Belongs to the UPF0176 family
M0D46_18525	COG1530	ribonuclease E activity
M0D46_18530	COG0564	pseudouridine synthase activity
M0D46_18535	COG3064	Membrane
M0D46_18540	COG0428	transporter
M0D46_18550	COG2154	pterin-4-alpha-carbinolamine dehydratase
M0D46_18655	COG0631	protein serine/threonine phosphatase activity
M0D46_18660	COG0515	serine threonine protein kinase
M0D46_18685	COG1858	cytochrome C peroxidase
M0D46_18710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D46_18715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D46_18740	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M0D46_18745	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_18810	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D46_18815	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D46_18830	COG1024	Enoyl-CoA hydratase
M0D46_18840	COG1024	Enoyl-CoA hydratase
M0D46_18845	COG1024	Enoyl-CoA hydratase
M0D46_18850	COG3424	synthase
M0D46_18925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M0D46_18945	COG0363	glucosamine-6-phosphate deaminase activity
M0D46_18970	COG1238	metal cluster binding
M0D46_19000	COG3279	Response regulator of the LytR AlgR family
M0D46_19005	COG3275	phosphorelay sensor kinase activity
M0D46_19035	COG4566	intracellular signal transduction
M0D46_19045	COG5001	Diguanylate cyclase
M0D46_19080	COG0243	molybdopterin cofactor binding
M0D46_19090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M0D46_19095	COG2223	nitrite transmembrane transporter activity
M0D46_19100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M0D46_19110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M0D46_19110	COG1648	precorrin-2 dehydrogenase activity
M0D46_19120	COG0746	molybdenum cofactor guanylyltransferase activity
M0D46_19125	COG0303	'Molybdopterin
M0D46_19135	COG0708	Exodeoxyribonuclease III
M0D46_19145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M0D46_19150	COG0303	'Molybdopterin
M0D46_19155	COG1160	GTP binding
M0D46_19160	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D46_19180	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M0D46_19195	COG1024	Enoyl-CoA hydratase
M0D46_19195	COG1250	3-hydroxyacyl-CoA dehydrogenase
M0D46_19200	COG0183	Belongs to the thiolase family
M0D46_19205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M0D46_19210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M0D46_19230	COG1674	ftsk spoiiie
M0D46_19235	COG0492	ferredoxin-NADP+ reductase activity
M0D46_19245	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M0D46_19255	COG0542	response to heat
M0D46_19270	COG0482	sulfurtransferase activity
M0D46_19300	COG4585	Histidine kinase
M0D46_19310	COG5002	protein histidine kinase activity
M0D46_19330	COG0784	Response regulator, receiver
M0D46_19330	COG0835	chemotaxis
M0D46_19340	COG1558	bacterial-type flagellum-dependent cell motility
M0D46_19345	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M0D46_19355	COG4787	bacterial-type flagellum-dependent cell motility
M0D46_19365	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M0D46_19370	COG1706	bacterial-type flagellum-dependent cell motility
M0D46_19375	COG1705	Flagellar rod assembly protein muramidase FlgJ
M0D46_19375	COG3951	Flagellar rod assembly protein muramidase FlgJ
M0D46_19385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M0D46_19395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M0D46_19400	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M0D46_19425	COG2197	response regulator
M0D46_19435	COG2201	protein-glutamate methylesterase activity
M0D46_19455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D46_19460	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_19465	COG1028	Short-chain dehydrogenase reductase Sdr
M0D46_19525	COG1677	Flagellar hook-basal body complex protein FliE
M0D46_19575	COG3190	flagellar
M0D46_19590	COG1684	flagellar biosynthetic protein fliR
M0D46_19645	COG2198	Histidine kinase
M0D46_19645	COG0784	Response regulator, receiver
M0D46_19645	COG0643	Histidine kinase
M0D46_19715	COG0793	Belongs to the peptidase S41A family
M0D46_19720	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M0D46_19725	COG1360	Flagellar Motor Protein
M0D46_19730	COG1192	Involved in chromosome partitioning
M0D46_19735	COG0835	chemotaxis
M0D46_19745	COG0745	RESPONSE REGULATOR receiver
M0D46_19755	COG0840	transmembrane signaling receptor activity
M0D46_19765	COG0840	transmembrane signaling receptor activity
M0D46_19770	COG0840	transmembrane signaling receptor activity
M0D46_19780	COG0840	transmembrane signaling receptor activity
M0D46_19785	COG0840	transmembrane signaling receptor activity
M0D46_19795	COG0840	transmembrane signaling receptor activity
M0D46_19805	COG0840	transmembrane signaling receptor activity
M0D46_19810	COG0840	transmembrane signaling receptor activity
M0D46_19815	COG0840	transmembrane signaling receptor activity
M0D46_19820	COG0840	transmembrane signaling receptor activity
M0D46_19830	COG0835	chemotaxis
M0D46_19840	COG0840	transmembrane signaling receptor activity
M0D46_19870	COG2267	carboxylic ester hydrolase activity
M0D46_19900	COG0318	PFAM AMP-dependent synthetase and ligase
M0D46_19905	COG1024	Enoyl-CoA hydratase
M0D46_19920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M0D46_19930	COG3279	Response regulator of the LytR AlgR family
M0D46_19945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M0D46_19955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D46_19960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M0D46_19970	COG0505	Belongs to the CarA family
M0D46_19975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M0D46_19985	COG2258	MOSC domain
M0D46_19990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M0D46_20035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M0D46_20055	COG0277	FAD linked oxidase domain protein
M0D46_20060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M0D46_20070	COG0531	amino acid
M0D46_20075	COG0531	amino acid
M0D46_20080	COG0235	Class ii aldolase
M0D46_20085	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M0D46_20105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M0D46_20105	COG0140	phosphoribosyl-ATP diphosphatase activity
M0D46_20110	COG0107	imidazoleglycerol-phosphate synthase activity
M0D46_20115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M0D46_20120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M0D46_20125	COG0131	Imidazoleglycerol-phosphate dehydratase
M0D46_20125	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M0D46_20130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D46_20135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M0D46_20150	COG0124	histidyl-tRNA synthetase
M0D46_20160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M0D46_20170	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M0D46_20220	COG3210	domain, Protein
M0D46_20240	COG1012	belongs to the aldehyde dehydrogenase family
M0D46_20255	COG0167	dihydroorotate dehydrogenase activity
M0D46_20260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M0D46_20265	COG0697	spore germination
M0D46_20270	COG1794	racemase activity, acting on amino acids and derivatives
M0D46_20280	COG0671	phosphoesterase, PA-phosphatase related
M0D46_20285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M0D46_20295	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
M0D46_20300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D46_20305	COG2203	Gaf domain
M0D46_20305	COG3706	GGDEF domain
M0D46_20305	COG4251	negative regulation of phosphorylation
M0D46_20305	COG5001	Diguanylate cyclase
M0D46_20315	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D46_20345	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M0D46_20350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M0D46_20355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M0D46_20365	COG0617	tRNA 3'-terminal CCA addition
M0D46_20375	COG1469	GTP cyclohydrolase I activity
M0D46_20380	COG0860	N-Acetylmuramoyl-L-alanine amidase
M0D46_20400	COG0477	Major facilitator Superfamily
M0D46_20410	COG1070	Carbohydrate kinase
M0D46_20420	COG1501	Belongs to the glycosyl hydrolase 31 family
M0D46_20460	COG0800	Aldolase
M0D46_20465	COG4948	Mandelate Racemase Muconate Lactonizing
M0D46_20475	COG3734	2-keto-3-deoxy-galactonokinase
M0D46_20480	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M0D46_20490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M0D46_20505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M0D46_20510	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M0D46_20525	COG0352	thiamine-phosphate diphosphorylase activity
M0D46_20525	COG0351	phosphomethylpyrimidine kinase
M0D46_20550	COG0583	DNA-binding transcription factor activity
M0D46_20555	COG1741	Belongs to the pirin family
M0D46_20570	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M0D46_20575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M0D46_20580	COG2137	regulation of response to DNA damage stimulus
M0D46_20585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M0D46_20595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D46_20600	COG1546	Belongs to the CinA family
M0D46_20605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M0D46_20615	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M0D46_20620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M0D46_20625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M0D46_20630	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M0D46_20635	COG1534	Rna-binding protein
M0D46_20640	COG3737	Protein of unknown function (DUF498/DUF598)
M0D46_20650	COG1238	metal cluster binding
M0D46_20655	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M0D46_20660	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M0D46_20665	COG2840	Smr protein MutS2
M0D46_20670	COG0585	pseudouridine synthase activity
M0D46_20675	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M0D46_20685	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M0D46_20690	COG0148	phosphopyruvate hydratase activity
M0D46_20705	COG0504	CTP synthase activity
M0D46_20725	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M0D46_20730	COG0306	phosphate transporter
M0D46_20740	COG1253	flavin adenine dinucleotide binding
M0D46_20755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M0D46_20760	COG0477	Major facilitator Superfamily
M0D46_20765	COG1132	(ABC) transporter
M0D46_20770	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M0D46_20785	COG0438	transferase activity, transferring glycosyl groups
M0D46_20795	COG2264	protein methyltransferase activity
M0D46_20800	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M0D46_20825	COG2244	polysaccharide biosynthetic process
M0D46_20890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M0D46_20900	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M0D46_20910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D46_20925	COG0784	Response regulator, receiver
M0D46_20925	COG4191	Histidine kinase
M0D46_20930	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M0D46_20935	COG0784	Response regulator, receiver
M0D46_20935	COG2205	protein histidine kinase activity
M0D46_20935	COG5002	protein histidine kinase activity
M0D46_20955	COG0840	transmembrane signaling receptor activity
M0D46_20970	COG0497	DNA recombination
M0D46_21060	COG0210	DNA helicase
M0D46_21105	COG0583	DNA-binding transcription factor activity
M0D46_21110	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M0D46_21115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M0D46_21130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M0D46_21135	COG0077	Prephenate dehydratase
M0D46_21135	COG1605	Chorismate mutase
M0D46_21140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M0D46_21145	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M0D46_21150	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
M0D46_21185	COG1228	amidohydrolase
M0D46_21190	COG2986	histidine ammonia-lyase
M0D46_21200	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M0D46_21215	COG4993	Dehydrogenase
M0D46_21230	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M0D46_21245	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M0D46_21250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M0D46_21255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D46_21265	COG3115	cell septum assembly
M0D46_21285	COG0360	Binds together with S18 to 16S ribosomal RNA
M0D46_21290	COG0316	Belongs to the HesB IscA family
M0D46_21295	COG0017	Asparaginyl-tRNA synthetase
M0D46_21320	COG0288	reversible hydration of carbon dioxide
M0D46_21335	COG3844	kynureninase activity
M0D46_21340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D46_21345	COG2925	Exonuclease
M0D46_21355	COG0667	Aldo Keto reductase
M0D46_21370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M0D46_21375	COG0116	Belongs to the methyltransferase superfamily
M0D46_21375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M0D46_21415	COG0494	nUDIX hydrolase
M0D46_21425	COG1024	Enoyl-CoA hydratase
M0D46_21435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M0D46_21440	COG0659	secondary active sulfate transmembrane transporter activity
M0D46_21465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M0D46_21470	COG0573	inorganic phosphate transmembrane transporter activity
M0D46_21475	COG0581	inorganic phosphate transmembrane transporter activity
M0D46_21485	COG0704	Plays a role in the regulation of phosphate uptake
M0D46_21505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M0D46_21515	COG0557	exoribonuclease II activity
M0D46_21530	COG1960	acyl-CoA dehydrogenase activity
M0D46_21535	COG2226	methyltransferase
M0D46_21540	COG0646	methionine synthase
M0D46_21540	COG1410	methionine synthase
M0D46_21560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D46_21585	COG2900	Belongs to the SlyX family
M0D46_21600	COG0386	Belongs to the glutathione peroxidase family
M0D46_21610	COG1725	Transcriptional regulator
M0D46_21615	COG1131	(ABC) transporter