locus-tag	class	description
M0D45_00040	COG3424	synthase
M0D45_00045	COG1024	Enoyl-CoA hydratase
M0D45_00050	COG1024	Enoyl-CoA hydratase
M0D45_00060	COG1024	Enoyl-CoA hydratase
M0D45_00075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D45_00080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D45_00090	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_00095	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M0D45_00120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D45_00125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D45_00150	COG1858	cytochrome C peroxidase
M0D45_00175	COG0515	serine threonine protein kinase
M0D45_00180	COG0631	protein serine/threonine phosphatase activity
M0D45_00290	COG2154	pterin-4-alpha-carbinolamine dehydratase
M0D45_00300	COG0428	transporter
M0D45_00305	COG3064	Membrane
M0D45_00315	COG1530	ribonuclease E activity
M0D45_00325	COG1054	Belongs to the UPF0176 family
M0D45_00345	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M0D45_00395	COG0322	excinuclease ABC activity
M0D45_00405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M0D45_00410	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M0D45_00415	COG1663	tetraacyldisaccharide 4'-kinase activity
M0D45_00420	COG1132	(ABC) transporter
M0D45_00430	COG0811	peptide transport
M0D45_00450	COG4591	ABC-type transport system involved in lipoprotein release permease component
M0D45_00460	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M0D45_00465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M0D45_00480	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M0D45_00485	COG2009	succinate dehydrogenase
M0D45_00510	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M0D45_00515	COG0837	glucose binding
M0D45_00520	COG0363	glucosamine-6-phosphate deaminase activity
M0D45_00525	COG0129	dihydroxy-acid dehydratase activity
M0D45_00530	COG0800	Aldolase
M0D45_00590	COG0582	viral genome integration into host DNA
M0D45_00650	COG1196	nuclear chromosome segregation
M0D45_00725	COG3728	DNA packaging
M0D45_00725	COG5484	DNA packaging
M0D45_00805	COG0305	Participates in initiation and elongation during chromosome replication
M0D45_00950	COG0784	Response regulator, receiver
M0D45_00950	COG5002	protein histidine kinase activity
M0D45_00950	COG2205	protein histidine kinase activity
M0D45_00955	COG2183	response to ionizing radiation
M0D45_00965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D45_00965	COG0723	plastoquinol--plastocyanin reductase activity
M0D45_00980	COG3243	poly(R)-hydroxyalkanoic acid synthase
M0D45_00990	COG1183	phosphatidylcholine synthase activity
M0D45_00995	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_01010	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M0D45_01020	COG0668	transmembrane transport
M0D45_01030	COG0590	tRNA wobble adenosine to inosine editing
M0D45_01040	COG1914	H( )-stimulated, divalent metal cation uptake system
M0D45_01055	COG2814	Major facilitator Superfamily
M0D45_01070	COG1335	isochorismatase
M0D45_01085	COG2197	response regulator
M0D45_01105	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_01135	COG0583	DNA-binding transcription factor activity
M0D45_01140	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M0D45_01145	COG3002	Belongs to the UPF0753 family
M0D45_01165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M0D45_01180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M0D45_01190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M0D45_01195	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M0D45_01205	COG0776	regulation of translation
M0D45_01210	COG0539	negative regulation of cytoplasmic translation
M0D45_01215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M0D45_01230	COG2957	Belongs to the agmatine deiminase family
M0D45_01235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M0D45_01260	COG0395	ABC-type sugar transport system, permease component
M0D45_01265	COG1175	transmembrane transport
M0D45_01295	COG2350	Protein conserved in bacteria
M0D45_01300	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M0D45_01305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M0D45_01310	COG1187	pseudouridine synthase activity
M0D45_01330	COG0436	Aminotransferase
M0D45_01335	COG4133	protoheme IX ABC transporter activity
M0D45_01355	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M0D45_01380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D45_01385	COG1278	Cold shock
M0D45_01395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M0D45_01400	COG4988	ABC transporter
M0D45_01410	COG1294	oxidase, subunit
M0D45_01470	COG0165	Argininosuccinate lyase
M0D45_01485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M0D45_01490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D45_01495	COG0137	argininosuccinate synthase activity
M0D45_01500	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M0D45_01510	COG0215	cysteine-tRNA ligase activity
M0D45_01515	COG2166	iron-sulfur cluster assembly
M0D45_01540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M0D45_01560	COG4302	ethanolamine ammonia-lyase activity
M0D45_01580	COG4677	pectinesterase activity
M0D45_01600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M0D45_01605	COG0402	S-adenosylhomocysteine deaminase activity
M0D45_01620	COG1509	lysine 2,3-aminomutase activity
M0D45_01625	COG3300	MHYT domain
M0D45_01625	COG5001	Diguanylate cyclase
M0D45_01640	COG0483	inositol monophosphate 1-phosphatase activity
M0D45_01645	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M0D45_01665	COG0488	(ABC) transporter
M0D45_01670	COG0513	Belongs to the DEAD box helicase family
M0D45_01675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M0D45_01680	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M0D45_01690	COG0625	glutathione transferase activity
M0D45_01700	COG1671	Belongs to the UPF0178 family
M0D45_01705	COG4681	YaeQ
M0D45_01710	COG2081	HI0933 family
M0D45_01720	COG0501	Belongs to the peptidase M48B family
M0D45_01725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D45_01730	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_01750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M0D45_01755	COG0860	N-Acetylmuramoyl-L-alanine amidase
M0D45_01760	COG0802	atpase or kinase
M0D45_01765	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M0D45_01765	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M0D45_01775	COG1570	exodeoxyribonuclease VII activity
M0D45_01785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M0D45_01830	COG0835	chemotaxis
M0D45_01840	COG1201	RNA secondary structure unwinding
M0D45_01860	COG2969	positive regulation of protein catabolic process
M0D45_01865	COG0625	glutathione transferase activity
M0D45_01870	COG2857	Cytochrome c1
M0D45_01875	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M0D45_01880	COG0723	plastoquinol--plastocyanin reductase activity
M0D45_01885	COG0741	lytic transglycosylase activity
M0D45_01905	COG1702	phosphate starvation-inducible protein PhoH
M0D45_01915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M0D45_01925	COG4535	Mg2 and Co2 transporter CorC
M0D45_01940	COG1012	belongs to the aldehyde dehydrogenase family
M0D45_01950	COG1177	transmembrane transport
M0D45_01955	COG1176	ABC-type spermidine putrescine transport system, permease component I
M0D45_01960	COG3842	ATPase activity
M0D45_01980	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M0D45_01995	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M0D45_02000	COG0174	glutamine synthetase
M0D45_02005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D45_02015	COG0477	Major facilitator Superfamily
M0D45_02025	COG0243	molybdopterin cofactor binding
M0D45_02030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M0D45_02035	COG2223	nitrite transmembrane transporter activity
M0D45_02040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M0D45_02050	COG2733	membrane
M0D45_02055	COG5002	protein histidine kinase activity
M0D45_02055	COG2205	protein histidine kinase activity
M0D45_02055	COG0784	Response regulator, receiver
M0D45_02065	COG0477	Major facilitator Superfamily
M0D45_02105	COG2902	Dehydrogenase
M0D45_02115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D45_02120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D45_02125	COG1609	Transcriptional regulator
M0D45_02130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M0D45_02130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D45_02135	COG1105	Belongs to the carbohydrate kinase PfkB family
M0D45_02140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M0D45_02140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M0D45_02180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M0D45_02190	COG1862	Preprotein translocase
M0D45_02195	COG0343	queuine tRNA-ribosyltransferase activity
M0D45_02200	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M0D45_02210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M0D45_02235	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M0D45_02240	COG3291	Pkd domain containing protein
M0D45_02250	COG0405	Gamma-glutamyltransferase
M0D45_02255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M0D45_02265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M0D45_02270	COG0742	ribosomal rna small subunit methyltransferase
M0D45_02275	COG0326	Molecular chaperone. Has ATPase activity
M0D45_02295	COG0823	Involved in the tonB-independent uptake of proteins
M0D45_02295	COG1506	peptidase
M0D45_02340	COG0531	amino acid
M0D45_02355	COG0006	proline dipeptidase activity
M0D45_02365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M0D45_02380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D45_02385	COG3938	Belongs to the proline racemase family
M0D45_02395	COG0552	protein localization to endoplasmic reticulum
M0D45_02400	COG1194	a g-specific adenine glycosylase
M0D45_02410	COG0784	Response regulator, receiver
M0D45_02410	COG4191	Histidine kinase
M0D45_02420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M0D45_02440	COG3040	lipid binding
M0D45_02450	COG1960	acyl-CoA dehydrogenase activity
M0D45_02460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M0D45_02480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D45_02490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D45_02515	COG0438	transferase activity, transferring glycosyl groups
M0D45_02525	COG0438	transferase activity, transferring glycosyl groups
M0D45_02530	COG0438	transferase activity, transferring glycosyl groups
M0D45_02580	COG0072	phenylalanine-tRNA ligase activity
M0D45_02580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D45_02585	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M0D45_02600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M0D45_02605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M0D45_02730	COG3702	type iv secretory pathway
M0D45_02750	COG2948	multi-organism process
M0D45_02770	COG3505	Type IV secretory pathway VirD4
M0D45_02785	COG0556	nucleotide-excision repair
M0D45_02830	COG1611	Belongs to the LOG family
M0D45_02840	COG2095	MarC family integral membrane protein
M0D45_02850	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M0D45_02885	COG1185	polyribonucleotide nucleotidyltransferase activity
M0D45_02890	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M0D45_02900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M0D45_02910	COG0195	Participates in both transcription termination and antitermination
M0D45_02915	COG0779	Required for maturation of 30S ribosomal subunits
M0D45_02925	COG1007	ATP synthesis coupled electron transport
M0D45_02945	COG0839	Belongs to the complex I subunit 6 family
M0D45_02955	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M0D45_02960	COG1034	ATP synthesis coupled electron transport
M0D45_02965	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M0D45_02970	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M0D45_02975	COG0649	NAD binding
M0D45_02980	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M0D45_02990	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M0D45_03005	COG0149	triose-phosphate isomerase activity
M0D45_03040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M0D45_03045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M0D45_03060	COG0133	tryptophan synthase activity
M0D45_03075	COG0135	phosphoribosylanthranilate isomerase activity
M0D45_03080	COG0101	tRNA pseudouridine synthase activity
M0D45_03095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M0D45_03100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M0D45_03105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M0D45_03110	COG2890	protein-(glutamine-N5) methyltransferase activity
M0D45_03120	COG0688	phosphatidylethanolamine metabolic process
M0D45_03130	COG0433	COG0433 Predicted ATPase
M0D45_03140	COG0494	nUDIX hydrolase
M0D45_03155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D45_03160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M0D45_03190	COG0717	Belongs to the dCTP deaminase family
M0D45_03195	COG0489	protein tyrosine kinase activity
M0D45_03215	COG3590	peptidase
M0D45_03220	COG3590	peptidase
M0D45_03240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M0D45_03245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D45_03250	COG2311	Membrane
M0D45_03255	COG1047	Peptidyl-prolyl cis-trans
M0D45_03260	COG0791	NLP P60 protein
M0D45_03265	COG0791	NLP P60 protein
M0D45_03280	COG2226	methyltransferase
M0D45_03285	COG1301	dicarboxylic acid transport
M0D45_03290	COG1785	Belongs to the alkaline phosphatase family
M0D45_03295	COG0037	tRNA processing
M0D45_03300	COG1722	exodeoxyribonuclease VII activity
M0D45_03305	COG0142	geranyltranstransferase activity
M0D45_03310	COG4104	PAAR repeat-containing protein
M0D45_03320	COG0312	modulator of DNA gyrase
M0D45_03325	COG3028	Belongs to the UPF0307 family
M0D45_03330	COG0312	modulator of DNA gyrase
M0D45_03340	COG3164	Protein of unknown function
M0D45_03355	COG2968	Membrane
M0D45_03375	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M0D45_03390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M0D45_03405	COG0495	leucyl-tRNA aminoacylation
M0D45_03415	COG3118	belongs to the thioredoxin family
M0D45_03495	COG1132	(ABC) transporter
M0D45_03515	COG3713	MltA-interacting MipA family protein
M0D45_03525	COG0745	RESPONSE REGULATOR receiver
M0D45_03530	COG5000	phosphorelay sensor kinase activity
M0D45_03530	COG5002	protein histidine kinase activity
M0D45_03535	COG0475	glutathione-regulated potassium exporter activity
M0D45_03545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M0D45_03570	COG1187	pseudouridine synthase activity
M0D45_03575	COG5001	Diguanylate cyclase
M0D45_03575	COG5002	protein histidine kinase activity
M0D45_03675	COG0667	Aldo Keto reductase
M0D45_03680	COG2814	Major facilitator Superfamily
M0D45_03685	COG0583	DNA-binding transcription factor activity
M0D45_03700	COG2207	Transcriptional regulator
M0D45_03710	COG1309	transcriptional regulator
M0D45_03720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D45_03735	COG0735	belongs to the Fur family
M0D45_03740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D45_03765	COG4452	Inner membrane protein CreD
M0D45_03775	COG2205	protein histidine kinase activity
M0D45_03785	COG0745	RESPONSE REGULATOR receiver
M0D45_03790	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M0D45_03800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M0D45_03810	COG2198	Histidine kinase
M0D45_03810	COG0643	Histidine kinase
M0D45_03815	COG0840	transmembrane signaling receptor activity
M0D45_03820	COG0835	chemotaxis
M0D45_03825	COG2200	EAL domain
M0D45_03825	COG2202	Pas domain
M0D45_03825	COG2199	diguanylate cyclase activity
M0D45_03830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M0D45_03840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D45_03845	COG3590	peptidase
M0D45_03855	COG0588	phosphoglycerate mutase activity
M0D45_03860	COG1515	deoxyribonuclease V activity
M0D45_03880	COG1741	Belongs to the pirin family
M0D45_03885	COG1966	Carbon starvation protein
M0D45_03890	COG2879	small protein
M0D45_03925	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M0D45_03930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M0D45_03935	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M0D45_03940	COG2080	2 iron, 2 sulfur cluster binding
M0D45_03950	COG4251	negative regulation of phosphorylation
M0D45_03950	COG5001	Diguanylate cyclase
M0D45_03950	COG3706	GGDEF domain
M0D45_03950	COG2203	Gaf domain
M0D45_03955	COG1609	Transcriptional regulator
M0D45_03965	COG2211	Major facilitator Superfamily
M0D45_03970	COG0673	inositol 2-dehydrogenase activity
M0D45_04015	COG0629	single-stranded DNA binding
M0D45_04020	COG0142	geranyltranstransferase activity
M0D45_04045	COG0527	aspartate kinase activity
M0D45_04050	COG0384	phenazine biosynthesis protein PhzF
M0D45_04055	COG0384	phenazine biosynthesis protein PhzF
M0D45_04065	COG1764	response to oxidative stress
M0D45_04070	COG0540	Belongs to the ATCase OTCase family
M0D45_04075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M0D45_04080	COG1678	Uncharacterized ACR, COG1678
M0D45_04085	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M0D45_04090	COG0519	Catalyzes the synthesis of GMP from XMP
M0D45_04115	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M0D45_04130	COG4942	peptidase
M0D45_04150	COG0693	protein deglycase activity
M0D45_04160	COG1959	2 iron, 2 sulfur cluster binding
M0D45_04170	COG0396	ATPase activity
M0D45_04175	COG0719	Fe-S assembly protein
M0D45_04180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M0D45_04190	COG2146	nitrite reductase [NAD(P)H] activity
M0D45_04195	COG4774	siderophore transport
M0D45_04200	COG3128	pkhd-type hydroxylase
M0D45_04230	COG1477	protein flavinylation
M0D45_04245	COG1555	photosystem II stabilization
M0D45_04250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D45_04260	COG3178	'Phosphotransferase
M0D45_04265	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M0D45_04275	COG0628	permease
M0D45_04285	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M0D45_04295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M0D45_04315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M0D45_04320	COG0271	Belongs to the BolA IbaG family
M0D45_04330	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M0D45_04340	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M0D45_04345	COG1137	ATPase activity
M0D45_04360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D45_04370	COG1660	Displays ATPase and GTPase activities
M0D45_04380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D45_04385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M0D45_04390	COG2239	Acts as a magnesium transporter
M0D45_04400	COG1294	oxidase, subunit
M0D45_04405	COG1271	oxidase subunit
M0D45_04415	COG1113	amino acid transport
M0D45_04435	COG0531	amino acid
M0D45_04495	COG2814	Major facilitator Superfamily
M0D45_04500	COG0754	glutathionylspermidine amidase activity
M0D45_04525	COG1842	Phage shock protein A
M0D45_04535	COG0259	pyridoxamine-phosphate oxidase activity
M0D45_04540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M0D45_04555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M0D45_04625	COG2204	response regulator
M0D45_04630	COG0477	Major facilitator Superfamily
M0D45_04640	COG0784	Response regulator, receiver
M0D45_04640	COG2205	protein histidine kinase activity
M0D45_04645	COG0784	Response regulator, receiver
M0D45_04645	COG5002	protein histidine kinase activity
M0D45_04650	COG0784	Response regulator, receiver
M0D45_04650	COG2198	Histidine kinase
M0D45_04650	COG2205	protein histidine kinase activity
M0D45_04655	COG2353	YceI-like domain
M0D45_04675	COG1760	l-serine dehydratase
M0D45_04685	COG0460	homoserine dehydrogenase
M0D45_04685	COG0527	aspartate kinase activity
M0D45_04690	COG0626	cystathionine gamma-synthase activity
M0D45_04695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D45_04700	COG0739	heme binding
M0D45_04705	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M0D45_04710	COG1272	protein, Hemolysin III
M0D45_04715	COG2982	Protein involved in outer membrane biogenesis
M0D45_04720	COG0516	GMP reductase activity
M0D45_04720	COG0517	IMP dehydrogenase activity
M0D45_04725	COG0463	Glycosyl transferase, family 2
M0D45_04730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M0D45_04735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M0D45_04745	COG4206	TonB-dependent receptor
M0D45_04750	COG1309	transcriptional regulator
M0D45_04760	COG1960	acyl-CoA dehydrogenase activity
M0D45_04785	COG0509	glycine decarboxylation via glycine cleavage system
M0D45_04790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M0D45_04800	COG0330	HflC and HflK could
M0D45_04805	COG1742	UPF0060 membrane protein
M0D45_04810	COG3956	TIGRFAM MazG family protein
M0D45_04820	COG0494	nUDIX hydrolase
M0D45_04830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M0D45_04835	COG0837	glucose binding
M0D45_04850	COG1388	LysM domain
M0D45_04850	COG3858	chitin binding
M0D45_04860	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M0D45_04870	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D45_04885	COG0531	amino acid
M0D45_04895	COG1486	melibiose metabolic process
M0D45_04905	COG3537	Alpha-1,2-mannosidase
M0D45_04940	COG3142	Participates in the control of copper homeostasis
M0D45_04945	COG1446	asparaginase
M0D45_04950	COG2304	oxidoreductase activity
M0D45_04955	COG1595	DNA-templated transcription, initiation
M0D45_04980	COG2198	Histidine kinase
M0D45_04980	COG0784	Response regulator, receiver
M0D45_04980	COG0643	Histidine kinase
M0D45_04985	COG0840	transmembrane signaling receptor activity
M0D45_04990	COG0835	chemotaxis
M0D45_05005	COG0189	ligase activity
M0D45_05015	COG1397	ADP-ribosylglycohydrolase
M0D45_05025	COG1199	ATP-dependent helicase activity
M0D45_05035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M0D45_05040	COG1215	transferase activity, transferring glycosyl groups
M0D45_05050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M0D45_05065	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
M0D45_05105	COG1643	Atp-dependent helicase
M0D45_05110	COG0783	Belongs to the Dps family
M0D45_05115	COG0514	ATP-dependent DNA helicase (RecQ)
M0D45_05135	COG1187	pseudouridine synthase activity
M0D45_05145	COG0840	transmembrane signaling receptor activity
M0D45_05175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M0D45_05185	COG0602	queuosine metabolic process
M0D45_05195	COG2885	chlorophyll binding
M0D45_05200	COG0823	Involved in the tonB-independent uptake of proteins
M0D45_05220	COG0824	Thioesterase
M0D45_05225	COG2255	four-way junction helicase activity
M0D45_05235	COG3158	transport of potassium into the cell
M0D45_05245	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M0D45_05265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M0D45_05280	COG0477	Major facilitator Superfamily
M0D45_05320	COG0488	(ABC) transporter
M0D45_05350	COG4651	solute:proton antiporter activity
M0D45_05350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M0D45_05375	COG4772	TonB-dependent receptor
M0D45_05385	COG4264	IucA IucC family
M0D45_05400	COG0019	diaminopimelate decarboxylase activity
M0D45_05430	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M0D45_05440	COG1492	cobalamin metabolic process
M0D45_05450	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M0D45_05475	COG4206	TonB-dependent receptor
M0D45_05485	COG0542	response to heat
M0D45_05535	COG1877	trehalose-phosphatase activity
M0D45_05540	COG3387	PFAM Glycoside hydrolase 15-related
M0D45_05555	COG0840	transmembrane signaling receptor activity
M0D45_05560	COG3011	Protein conserved in bacteria
M0D45_05575	COG0564	pseudouridine synthase activity
M0D45_05580	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D45_05585	COG0537	adenosine 5'-monophosphoramidase activity
M0D45_05590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M0D45_05590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M0D45_05605	COG0045	succinate-CoA ligase (ADP-forming) activity
M0D45_05665	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M0D45_05670	COG0237	dephospho-CoA kinase activity
M0D45_05705	COG0745	RESPONSE REGULATOR receiver
M0D45_05790	COG2801	Transposase and inactivated derivatives
M0D45_05805	COG2003	Belongs to the UPF0758 family
M0D45_05890	COG2022	thiamine diphosphate biosynthetic process
M0D45_05900	COG3273	potassium ion transport
M0D45_05900	COG0471	metal ion transport
M0D45_05920	COG1970	mechanosensitive ion channel activity
M0D45_05930	COG1609	Transcriptional regulator
M0D45_05950	COG3250	beta-galactosidase activity
M0D45_05955	COG4948	Mandelate Racemase Muconate Lactonizing
M0D45_05965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M0D45_05975	COG0308	aminopeptidase N
M0D45_05990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D45_06000	COG0529	Catalyzes the synthesis of activated sulfate
M0D45_06000	COG2895	sulfate adenylyltransferase (ATP) activity
M0D45_06005	COG0175	sulfate reduction
M0D45_06010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M0D45_06015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M0D45_06020	COG0175	sulfate reduction
M0D45_06040	COG2205	protein histidine kinase activity
M0D45_06040	COG2198	Histidine kinase
M0D45_06040	COG0784	Response regulator, receiver
M0D45_06050	COG0583	DNA-binding transcription factor activity
M0D45_06075	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M0D45_06080	COG3588	fructose-bisphosphate aldolase
M0D45_06085	COG0469	pyruvate kinase activity
M0D45_06115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M0D45_06125	COG3047	cAMP biosynthetic process
M0D45_06135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M0D45_06135	COG3453	Protein conserved in bacteria
M0D45_06140	COG0725	ABC transporter, periplasmic molybdate-binding protein
M0D45_06145	COG4149	molybdate abc transporter
M0D45_06150	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M0D45_06170	COG0642	Histidine kinase
M0D45_06185	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_06220	COG1376	ErfK ybiS ycfS ynhG family protein
M0D45_06225	COG0739	heme binding
M0D45_06230	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_06235	COG0583	DNA-binding transcription factor activity
M0D45_06240	COG4773	Receptor
M0D45_06250	COG1301	dicarboxylic acid transport
M0D45_06260	COG2304	oxidoreductase activity
M0D45_06280	COG0714	Associated with various cellular activities
M0D45_06310	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M0D45_06340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M0D45_06350	COG2721	sulfolactate sulfo-lyase activity
M0D45_06365	COG2271	Major facilitator Superfamily
M0D45_06380	COG0583	DNA-binding transcription factor activity
M0D45_06390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M0D45_06400	COG2390	Transcriptional regulator
M0D45_06410	COG3659	wide pore channel activity
M0D45_06415	COG1175	transmembrane transport
M0D45_06430	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_06435	COG1070	Carbohydrate kinase
M0D45_06450	COG1561	YicC-like family, N-terminal region
M0D45_06455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M0D45_06465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M0D45_06470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M0D45_06485	COG0006	proline dipeptidase activity
M0D45_06495	COG0006	proline dipeptidase activity
M0D45_06520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M0D45_06540	COG2912	Transglutaminase-like superfamily
M0D45_06545	COG1773	rubredoxin
M0D45_06550	COG0352	thiamine-phosphate diphosphorylase activity
M0D45_06565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M0D45_06580	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M0D45_06585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D45_06615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M0D45_06630	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_06640	COG0671	phosphoesterase, PA-phosphatase related
M0D45_06645	COG3781	membrane
M0D45_06655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M0D45_06660	COG0563	adenylate kinase activity
M0D45_06690	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
M0D45_06700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M0D45_06720	COG3710	Transcriptional regulator
M0D45_06725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M0D45_06730	COG1506	peptidase
M0D45_06730	COG0823	Involved in the tonB-independent uptake of proteins
M0D45_06730	COG4946	Tricorn protease homolog
M0D45_06735	COG0840	transmembrane signaling receptor activity
M0D45_06740	COG0405	Gamma-glutamyltransferase
M0D45_06745	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M0D45_06765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M0D45_06770	COG0473	3-isopropylmalate dehydrogenase activity
M0D45_06780	COG0066	3-isopropylmalate dehydratase activity
M0D45_06785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M0D45_06805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M0D45_06810	COG1538	Outer membrane efflux protein
M0D45_06815	COG1519	Transferase
M0D45_06820	COG1560	Kdo2-lipid A biosynthetic process
M0D45_06905	COG0281	malic enzyme
M0D45_06905	COG0280	phosphate acetyltransferase
M0D45_06910	COG1301	dicarboxylic acid transport
M0D45_06925	COG4191	Histidine kinase
M0D45_06940	COG0583	DNA-binding transcription factor activity
M0D45_06945	COG0667	Aldo Keto reductase
M0D45_06965	COG2197	response regulator
M0D45_06975	COG0642	Histidine kinase
M0D45_06990	COG2851	Citrate transporter
M0D45_06995	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_07000	COG1609	Transcriptional regulator
M0D45_07005	COG2211	Major facilitator Superfamily
M0D45_07035	COG1162	GTPase activity
M0D45_07040	COG0436	Aminotransferase
M0D45_07060	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M0D45_07075	COG3964	amidohydrolase
M0D45_07080	COG0402	S-adenosylhomocysteine deaminase activity
M0D45_07115	COG1307	EDD domain protein, DegV family
M0D45_07125	COG0697	spore germination
M0D45_07130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M0D45_07155	COG3791	Glutathione-dependent formaldehyde-activating
M0D45_07180	COG2205	protein histidine kinase activity
M0D45_07190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M0D45_07205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M0D45_07215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M0D45_07220	COG1012	belongs to the aldehyde dehydrogenase family
M0D45_07225	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M0D45_07245	COG1183	phosphatidylcholine synthase activity
M0D45_07255	COG0442	prolyl-tRNA aminoacylation
M0D45_07270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M0D45_07275	COG1127	ABC transporter
M0D45_07280	COG3218	ABC-type transport auxiliary lipoprotein component
M0D45_07280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M0D45_07315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M0D45_07320	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M0D45_07320	COG0662	Cupin 2, conserved barrel domain protein
M0D45_07345	COG2086	electron transfer activity
M0D45_07360	COG0546	phosphoglycolate phosphatase activity
M0D45_07360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M0D45_07365	COG0277	FAD linked oxidase domain protein
M0D45_07370	COG0300	oxidoreductase activity
M0D45_07380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D45_07400	COG2226	methyltransferase
M0D45_07410	COG3754	Rhamnan synthesis protein F
M0D45_07415	COG1216	Glycosyl transferase, family 2
M0D45_07415	COG0438	transferase activity, transferring glycosyl groups
M0D45_07435	COG0626	cystathionine gamma-synthase activity
M0D45_07465	COG0625	glutathione transferase activity
M0D45_07475	COG0513	Belongs to the DEAD box helicase family
M0D45_07480	COG0720	synthase
M0D45_07490	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M0D45_07495	COG1956	GAF domain-containing protein
M0D45_07510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M0D45_07515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M0D45_07530	COG0339	signal peptide processing
M0D45_07580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M0D45_07585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D45_07590	COG0577	efflux transmembrane transporter activity
M0D45_07590	COG1136	(ABC) transporter
M0D45_07595	COG1136	(ABC) transporter
M0D45_07595	COG0577	efflux transmembrane transporter activity
M0D45_07600	COG0577	efflux transmembrane transporter activity
M0D45_07600	COG1136	(ABC) transporter
M0D45_07620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M0D45_07645	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M0D45_07650	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M0D45_07655	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M0D45_07660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M0D45_07670	COG0356	it plays a direct role in the translocation of protons across the membrane
M0D45_07690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M0D45_07700	COG0508	dehydrogenase complex catalyzes the overall conversion of
M0D45_07740	COG2011	ABC-type metal ion transport system permease component
M0D45_07745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M0D45_07750	COG0697	spore germination
M0D45_07765	COG3850	Histidine kinase
M0D45_07765	COG4999	Histidine kinase
M0D45_07765	COG2205	protein histidine kinase activity
M0D45_07765	COG3437	response regulator, receiver
M0D45_07785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D45_07790	COG1187	pseudouridine synthase activity
M0D45_07795	COG2813	Specifically methylates the guanine in position
M0D45_07815	COG2205	protein histidine kinase activity
M0D45_07815	COG2202	Pas domain
M0D45_07835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M0D45_07840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D45_07885	COG0745	RESPONSE REGULATOR receiver
M0D45_07900	COG1404	Belongs to the peptidase S8 family
M0D45_07935	COG0842	Transport permease protein
M0D45_07940	COG1131	(ABC) transporter
M0D45_07945	COG0025	NhaP-type Na H and K H
M0D45_07955	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M0D45_07960	COG1573	uracil-dna glycosylase
M0D45_07970	COG3384	dioxygenase
M0D45_07980	COG0583	DNA-binding transcription factor activity
M0D45_07990	COG0667	Aldo Keto reductase
M0D45_08005	COG3590	peptidase
M0D45_08020	COG0531	amino acid
M0D45_08035	COG2972	Histidine kinase
M0D45_08050	COG3685	Protein conserved in bacteria
M0D45_08055	COG3546	catalase activity
M0D45_08070	COG1271	oxidase subunit
M0D45_08075	COG1294	oxidase, subunit
M0D45_08090	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_08100	COG1063	alcohol dehydrogenase
M0D45_08160	COG1131	(ABC) transporter
M0D45_08175	COG0251	oxidation-reduction process
M0D45_08205	COG0659	secondary active sulfate transmembrane transporter activity
M0D45_08210	COG0038	chloride channel
M0D45_08220	COG0024	Methionine aminopeptidase
M0D45_08235	COG1999	signal sequence binding
M0D45_08320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M0D45_08325	COG1490	D-aminoacyl-tRNA deacylase activity
M0D45_08330	COG1560	Kdo2-lipid A biosynthetic process
M0D45_08375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M0D45_08375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M0D45_08380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M0D45_08385	COG0242	peptide deformylase activity
M0D45_08390	COG1652	LysM domain
M0D45_08395	COG0758	DNA mediated transformation
M0D45_08415	COG1754	DNA topoisomerase type I activity
M0D45_08415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M0D45_08420	COG0009	L-threonylcarbamoyladenylate synthase
M0D45_08435	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_08445	COG0616	signal peptide processing
M0D45_08450	COG0534	Mate efflux family protein
M0D45_08470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M0D45_08475	COG0625	glutathione transferase activity
M0D45_08490	COG1252	NADH dehydrogenase
M0D45_08495	COG2860	membrane
M0D45_08500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M0D45_08505	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M0D45_08510	COG2201	protein-glutamate methylesterase activity
M0D45_08515	COG2177	Part of the ABC transporter FtsEX involved in
M0D45_08520	COG2884	Cell division ATP-binding protein ftsE
M0D45_08530	COG3118	belongs to the thioredoxin family
M0D45_08535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M0D45_08545	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
M0D45_08570	COG1652	LysM domain
M0D45_08575	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M0D45_08575	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M0D45_08580	COG1473	amidohydrolase
M0D45_08585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D45_08590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D45_08615	COG5383	Protein conserved in bacteria
M0D45_08650	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
M0D45_08655	COG3023	N-Acetylmuramoyl-L-alanine amidase
M0D45_08665	COG4948	Mandelate Racemase Muconate Lactonizing
M0D45_08675	COG0531	amino acid
M0D45_08690	COG4682	membrane
M0D45_08695	COG2133	pyrroloquinoline quinone binding
M0D45_08705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M0D45_08710	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M0D45_08720	COG1610	YqeY-like protein
M0D45_08730	COG1295	ribonuclease BN
M0D45_08735	COG0358	DNA primase activity
M0D45_08785	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M0D45_08800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M0D45_08845	COG0739	heme binding
M0D45_08860	COG2223	nitrite transmembrane transporter activity
M0D45_08865	COG0708	Exodeoxyribonuclease III
M0D45_08880	COG1192	Involved in chromosome partitioning
M0D45_08885	COG1475	DNA binding
M0D45_08900	COG0463	Glycosyl transferase, family 2
M0D45_08925	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M0D45_08930	COG2003	Belongs to the UPF0758 family
M0D45_08935	COG0018	arginyl-trna synthetase
M0D45_08950	COG4221	oxidoreductase activity
M0D45_08955	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M0D45_08955	COG2755	lipolytic protein G-D-S-L family
M0D45_08965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M0D45_08970	COG1166	arginine decarboxylase activity
M0D45_08975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M0D45_08995	COG3291	Pkd domain containing protein
M0D45_08995	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M0D45_09010	COG0606	chelatase, subunit chli
M0D45_09025	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M0D45_09055	COG1690	Belongs to the RtcB family
M0D45_09095	COG1090	epimerase
M0D45_09105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M0D45_09125	COG0628	permease
M0D45_09130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D45_09135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M0D45_09140	COG0753	catalase activity
M0D45_09155	COG2197	response regulator
M0D45_09160	COG4585	Histidine kinase
M0D45_09165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D45_09170	COG1136	(ABC) transporter
M0D45_09195	COG0697	spore germination
M0D45_09220	COG0180	Tryptophanyl-tRNA synthetase
M0D45_09225	COG3237	CsbD-like
M0D45_09265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M0D45_09280	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M0D45_09325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M0D45_09360	COG1199	ATP-dependent helicase activity
M0D45_09450	COG0625	glutathione transferase activity
M0D45_09485	COG4555	ABC transporter
M0D45_09495	COG1476	TRANSCRIPTIONal
M0D45_09515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M0D45_09520	COG1131	(ABC) transporter
M0D45_09525	COG0842	Transport permease protein
M0D45_09530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M0D45_09545	COG1607	acyl-coa hydrolase
M0D45_09560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M0D45_09565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M0D45_09575	COG1042	CoA-binding domain protein
M0D45_09575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M0D45_09575	COG0045	succinate-CoA ligase (ADP-forming) activity
M0D45_09585	COG2239	Acts as a magnesium transporter
M0D45_09605	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M0D45_09610	COG3387	PFAM Glycoside hydrolase 15-related
M0D45_09625	COG3100	YcgL domain-containing protein
M0D45_09630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M0D45_09640	COG0463	Glycosyl transferase, family 2
M0D45_09660	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_09700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M0D45_09705	COG0644	oxidoreductase
M0D45_09720	COG0823	Involved in the tonB-independent uptake of proteins
M0D45_09720	COG1506	peptidase
M0D45_09720	COG4946	Tricorn protease homolog
M0D45_09735	COG0408	coproporphyrinogen oxidase activity
M0D45_09745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M0D45_09745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M0D45_09835	COG0210	DNA helicase
M0D45_09850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D45_09855	COG0583	DNA-binding transcription factor activity
M0D45_09860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M0D45_09870	COG2159	amidohydrolase
M0D45_09895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D45_09915	COG0357	Ribosomal RNA small subunit methyltransferase G
M0D45_09920	COG3540	Alkaline phosphatase
M0D45_09930	COG2091	lysine biosynthetic process via aminoadipic acid
M0D45_09950	COG1940	carbohydrate kinase activity
M0D45_09955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M0D45_09960	COG3162	membrane
M0D45_10010	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_10015	COG0179	Fumarylacetoacetate (FAA) hydrolase
M0D45_10020	COG4948	Mandelate Racemase Muconate Lactonizing
M0D45_10025	COG3254	rhamnose metabolic process
M0D45_10030	COG0738	Major facilitator superfamily
M0D45_10035	COG1414	Transcriptional regulator
M0D45_10055	COG2205	protein histidine kinase activity
M0D45_10065	COG3459	Glycosyltransferase 36 associated
M0D45_10070	COG2211	Major facilitator Superfamily
M0D45_10075	COG3265	gluconokinase activity
M0D45_10080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D45_10100	COG2911	Protein conserved in bacteria
M0D45_10105	COG0729	surface antigen
M0D45_10110	COG4771	TonB-dependent receptor
M0D45_10115	COG0457	Tetratricopeptide repeat
M0D45_10125	COG0752	glycyl-tRNA synthetase alpha subunit
M0D45_10130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M0D45_10140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M0D45_10140	COG0519	Catalyzes the synthesis of GMP from XMP
M0D45_10150	COG0805	protein transport
M0D45_10155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M0D45_10160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M0D45_10170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M0D45_10185	COG2974	May be involved in recombination
M0D45_10210	COG3661	Belongs to the glycosyl hydrolase 67 family
M0D45_10220	COG4948	Mandelate Racemase Muconate Lactonizing
M0D45_10230	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D45_10235	COG0246	Mannitol dehydrogenase
M0D45_10260	COG3386	PFAM SMP-30 Gluconolaconase
M0D45_10300	COG1904	glucuronate isomerase
M0D45_10320	COG3693	PFAM glycoside hydrolase, family 10
M0D45_10335	COG2211	Major facilitator Superfamily
M0D45_10350	COG0393	Putative heavy-metal-binding
M0D45_10380	COG2937	Belongs to the GPAT DAPAT family
M0D45_10410	COG0284	orotidine-5'-phosphate decarboxylase activity
M0D45_10415	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M0D45_10420	COG3132	Protein of unknown function, DUF480
M0D45_10435	COG0210	DNA helicase
M0D45_10440	COG1435	thymidine kinase activity
M0D45_10450	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M0D45_10460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M0D45_10490	COG3135	benzoate transporter
M0D45_10510	COG0676	glucose-6-phosphate 1-epimerase activity
M0D45_10520	COG3012	SEC-C Motif Domain Protein
M0D45_10525	COG0730	response to heat
M0D45_10545	COG0302	gtp cyclohydrolase
M0D45_10560	COG1566	PFAM secretion protein HlyD family protein
M0D45_10570	COG1289	transmembrane transporter activity
M0D45_10575	COG0477	Major facilitator Superfamily
M0D45_10600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D45_10645	COG0564	pseudouridine synthase activity
M0D45_10680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M0D45_10685	COG1074	ATP-dependent DNA helicase activity
M0D45_10690	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M0D45_10695	COG1127	ABC transporter
M0D45_10700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M0D45_10720	COG2853	Lipoprotein
M0D45_10730	COG0386	Belongs to the glutathione peroxidase family
M0D45_10740	COG1322	Protein conserved in bacteria
M0D45_10745	COG0604	alcohol dehydrogenase
M0D45_10750	COG0583	DNA-binding transcription factor activity
M0D45_10770	COG0531	amino acid
M0D45_10775	COG3537	Alpha-1,2-mannosidase
M0D45_10795	COG3706	GGDEF domain
M0D45_10805	COG1929	Belongs to the glycerate kinase type-1 family
M0D45_10810	COG2271	Major facilitator Superfamily
M0D45_10825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M0D45_10830	COG0861	Integral membrane protein TerC family
M0D45_10840	COG0584	glycerophosphoryl diester phosphodiesterase
M0D45_10855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M0D45_10860	COG0726	polysaccharide deacetylase
M0D45_10880	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M0D45_10895	COG0187	DNA topoisomerase II activity
M0D45_10905	COG0501	Belongs to the peptidase M48B family
M0D45_10940	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M0D45_10950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D45_10990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M0D45_10995	COG0793	Belongs to the peptidase S41A family
M0D45_11000	COG4942	peptidase
M0D45_11010	COG2234	aminopeptidase activity
M0D45_11020	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D45_11025	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D45_11030	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D45_11035	COG1064	alcohol dehydrogenase
M0D45_11045	COG0493	'glutamate synthase
M0D45_11050	COG0069	glutamate synthase activity
M0D45_11050	COG0067	glutamate synthase
M0D45_11050	COG0070	glutamate synthase
M0D45_11100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M0D45_11120	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M0D45_11125	COG0297	glycogen (starch) synthase activity
M0D45_11125	COG0438	transferase activity, transferring glycosyl groups
M0D45_11145	COG0367	asparagine synthase
M0D45_11175	COG1132	(ABC) transporter
M0D45_11285	COG1111	helicase
M0D45_11285	COG1205	dead DEAH box helicase
M0D45_11290	COG1272	protein, Hemolysin III
M0D45_11300	COG0625	glutathione transferase activity
M0D45_11310	COG3237	CsbD-like
M0D45_11370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D45_11375	COG0477	Major facilitator Superfamily
M0D45_11415	COG0714	Associated with various cellular activities
M0D45_11465	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M0D45_11475	COG4772	TonB-dependent receptor
M0D45_11480	COG1012	belongs to the aldehyde dehydrogenase family
M0D45_11505	COG1304	FMN binding
M0D45_11510	COG1755	Isoprenylcysteine carboxyl methyltransferase
M0D45_11515	COG4585	Histidine kinase
M0D45_11520	COG2197	response regulator
M0D45_11540	COG3710	Transcriptional regulator
M0D45_11545	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M0D45_11665	COG3210	domain, Protein
M0D45_11670	COG2831	hemolysin activation secretion protein
M0D45_11675	COG0366	Alpha amylase catalytic
M0D45_11680	COG0366	Alpha amylase catalytic
M0D45_11685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M0D45_11710	COG0657	acetylesterase activity
M0D45_11710	COG2755	lipolytic protein G-D-S-L family
M0D45_11720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M0D45_11740	COG1609	Transcriptional regulator
M0D45_11745	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M0D45_11750	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_11760	COG2755	lipolytic protein G-D-S-L family
M0D45_11770	COG3186	Phenylalanine-4-hydroxylase
M0D45_11775	COG1522	sequence-specific DNA binding
M0D45_11785	COG1752	Esterase of the alpha-beta hydrolase superfamily
M0D45_11790	COG1473	amidohydrolase
M0D45_11800	COG1119	ATPase activity
M0D45_11815	COG0517	IMP dehydrogenase activity
M0D45_11815	COG1125	glycine betaine transport
M0D45_11835	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
M0D45_11840	COG3550	peptidyl-serine autophosphorylation
M0D45_11845	COG3620	sequence-specific DNA binding
M0D45_11865	COG0489	protein tyrosine kinase activity
M0D45_11870	COG2062	phosphohistidine phosphatase, SixA
M0D45_11880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D45_11915	COG4221	oxidoreductase activity
M0D45_11915	COG3321	synthase
M0D45_11915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M0D45_11915	COG0604	alcohol dehydrogenase
M0D45_11925	COG1968	undecaprenyl-diphosphatase activity
M0D45_11930	COG0174	glutamine synthetase
M0D45_11935	COG0347	Belongs to the P(II) protein family
M0D45_11940	COG0004	ammonium transporteR
M0D45_11945	COG3852	Histidine kinase
M0D45_11950	COG2204	response regulator
M0D45_11955	COG2032	superoxide dismutase activity
M0D45_11960	COG2032	superoxide dismutase activity
M0D45_11975	COG0183	Belongs to the thiolase family
M0D45_12015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M0D45_12020	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M0D45_12025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M0D45_12035	COG0028	Belongs to the TPP enzyme family
M0D45_12040	COG2205	protein histidine kinase activity
M0D45_12065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M0D45_12080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D45_12090	COG0596	Alpha beta hydrolase
M0D45_12095	COG0727	PFAM Uncharacterised protein family (UPF0153)
M0D45_12100	COG0318	PFAM AMP-dependent synthetase and ligase
M0D45_12105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D45_12115	COG1181	Belongs to the D-alanine--D-alanine ligase family
M0D45_12125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D45_12140	COG0564	pseudouridine synthase activity
M0D45_12160	COG1446	asparaginase
M0D45_12165	COG0339	signal peptide processing
M0D45_12170	COG0681	Belongs to the peptidase S26 family
M0D45_12200	COG0475	glutathione-regulated potassium exporter activity
M0D45_12205	COG0583	DNA-binding transcription factor activity
M0D45_12210	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M0D45_12215	COG2224	Isocitrate lyase
M0D45_12245	COG4770	biotin carboxylase activity
M0D45_12250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M0D45_12255	COG1960	acyl-CoA dehydrogenase activity
M0D45_12310	COG0523	cobalamin synthesis protein
M0D45_12320	COG0697	spore germination
M0D45_12330	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M0D45_12335	COG1846	Transcriptional regulator
M0D45_12340	COG1764	response to oxidative stress
M0D45_12360	COG0656	L-ascorbic acid biosynthetic process
M0D45_12365	COG2130	NADP-dependent
M0D45_12380	COG1187	pseudouridine synthase activity
M0D45_12390	COG1643	Atp-dependent helicase
M0D45_12395	COG4807	Protein conserved in bacteria
M0D45_12400	COG2351	hydroxyisourate hydrolase activity
M0D45_12405	COG2072	flavoprotein involved in K transport
M0D45_12425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M0D45_12440	COG0596	Alpha beta hydrolase
M0D45_12520	COG2252	PERMEase
M0D45_12540	COG0084	hydrolase, TatD family'
M0D45_12545	COG0583	DNA-binding transcription factor activity
M0D45_12550	COG2814	Major facilitator Superfamily
M0D45_12565	COG0596	Alpha beta hydrolase
M0D45_12570	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M0D45_12575	COG1902	pentaerythritol trinitrate reductase activity
M0D45_12630	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M0D45_12635	COG0583	DNA-binding transcription factor activity
M0D45_12665	COG0702	epimerase
M0D45_12670	COG1733	regulation of RNA biosynthetic process
M0D45_12715	COG0129	dihydroxy-acid dehydratase activity
M0D45_12725	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M0D45_12780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M0D45_12785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M0D45_12815	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M0D45_12820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M0D45_12830	COG3485	protocatechuate 3,4-dioxygenase
M0D45_12835	COG3485	protocatechuate 3,4-dioxygenase
M0D45_12845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D45_12850	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M0D45_12865	COG1414	Transcriptional regulator
M0D45_12875	COG0657	acetylesterase activity
M0D45_12885	COG0445	tRNA wobble uridine modification
M0D45_12900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M0D45_12925	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_12940	COG0156	8-amino-7-oxononanoate synthase activity
M0D45_12945	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M0D45_12950	COG1040	competence protein
M0D45_12955	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M0D45_13035	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M0D45_13110	COG3264	Mechanosensitive ion channel
M0D45_13110	COG1511	domain protein
M0D45_13115	COG1368	sulfuric ester hydrolase activity
M0D45_13120	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D45_13125	COG2354	Protein conserved in bacteria
M0D45_13130	COG1649	PFAM Uncharacterised BCR, COG1649
M0D45_13140	COG0297	glycogen (starch) synthase activity
M0D45_13145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M0D45_13150	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M0D45_13175	COG0702	epimerase
M0D45_13185	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_13205	COG0513	Belongs to the DEAD box helicase family
M0D45_13230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M0D45_13245	COG3104	oligopeptide transport
M0D45_13265	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M0D45_13285	COG1320	monovalent cation:proton antiporter activity
M0D45_13290	COG2212	antiporter activity
M0D45_13300	COG0651	ATP synthesis coupled electron transport
M0D45_13305	COG1006	Multisubunit Na H antiporter MnhC subunit
M0D45_13310	COG2111	Na H antiporter
M0D45_13310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M0D45_13355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M0D45_13365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M0D45_13370	COG0456	acetyltransferase
M0D45_13375	COG1597	lipid kinase activity
M0D45_13405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M0D45_13410	COG0134	indole-3-glycerol-phosphate synthase activity
M0D45_13420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M0D45_13435	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
M0D45_13445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M0D45_13500	COG0316	Belongs to the HesB IscA family
M0D45_13515	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M0D45_13530	COG2814	Major facilitator Superfamily
M0D45_13540	COG2814	Major facilitator Superfamily
M0D45_13545	COG1289	transmembrane transporter activity
M0D45_13555	COG0151	Belongs to the GarS family
M0D45_13560	COG0138	bifunctional purine biosynthesis protein purh
M0D45_13575	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M0D45_13620	COG0439	Biotin carboxylase
M0D45_13630	COG0511	ligase activity, forming carbon-carbon bonds
M0D45_13635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M0D45_13640	COG1505	serine-type exopeptidase activity
M0D45_13650	COG1324	tolerance protein
M0D45_13655	COG2356	endonuclease I
M0D45_13665	COG0459	protein refolding
M0D45_13700	COG3039	Transposase
M0D45_13715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M0D45_13730	COG3386	PFAM SMP-30 Gluconolaconase
M0D45_13740	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M0D45_13745	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M0D45_13770	COG0778	Nitroreductase
M0D45_13775	COG2353	YceI-like domain
M0D45_13815	COG3052	prosthetic group binding
M0D45_13840	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M0D45_13850	COG1802	Transcriptional regulator
M0D45_14045	COG4221	oxidoreductase activity
M0D45_14055	COG0435	Glutathione S-transferase
M0D45_14075	COG2409	Drug exporters of the RND superfamily
M0D45_14130	COG0697	spore germination
M0D45_14135	COG4305	rare lipoprotein A
M0D45_14140	COG5297	Belongs to the glycosyl hydrolase family 6
M0D45_14150	COG1113	amino acid transport
M0D45_14160	COG0598	Magnesium transport protein CorA
M0D45_14220	COG0840	transmembrane signaling receptor activity
M0D45_14225	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D45_14225	COG5297	Belongs to the glycosyl hydrolase family 6
M0D45_14230	COG0659	secondary active sulfate transmembrane transporter activity
M0D45_14245	COG2943	transferase activity, transferring hexosyl groups
M0D45_14255	COG3275	phosphorelay sensor kinase activity
M0D45_14265	COG0181	hydroxymethylbilane synthase activity
M0D45_14290	COG1505	serine-type exopeptidase activity
M0D45_14305	COG0436	Aminotransferase
M0D45_14315	COG2832	Protein of unknown function (DUF454)
M0D45_14325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M0D45_14335	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M0D45_14345	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M0D45_14355	COG2153	protein acetylation
M0D45_14370	COG2226	methyltransferase
M0D45_14375	COG3300	MHYT domain
M0D45_14375	COG5001	Diguanylate cyclase
M0D45_14380	COG0308	aminopeptidase N
M0D45_14425	COG3284	Transcriptional regulator
M0D45_14440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D45_14445	COG1077	Cell shape determining protein MreB Mrl
M0D45_14455	COG1792	Involved in formation and maintenance of cell shape
M0D45_14470	COG0772	Belongs to the SEDS family
M0D45_14480	COG5434	Belongs to the glycosyl hydrolase 28 family
M0D45_14485	COG2951	lytic endotransglycosylase activity
M0D45_14490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M0D45_14495	COG1686	Belongs to the peptidase S11 family
M0D45_14505	COG2921	Belongs to the UPF0250 family
M0D45_14510	COG0321	lipoyl(octanoyl) transferase activity
M0D45_14515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M0D45_14530	COG0583	DNA-binding transcription factor activity
M0D45_14540	COG1051	belongs to the nudix hydrolase family
M0D45_14540	COG1056	cytidyltransferase-related domain
M0D45_14575	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M0D45_14580	COG0673	inositol 2-dehydrogenase activity
M0D45_14585	COG2823	Periplasmic or secreted lipoprotein
M0D45_14590	COG4251	negative regulation of phosphorylation
M0D45_14595	COG0784	Response regulator, receiver
M0D45_14600	COG4191	Histidine kinase
M0D45_14605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M0D45_14660	COG1459	type II secretion system
M0D45_14680	COG4795	General secretion pathway protein
M0D45_14710	COG3250	beta-galactosidase activity
M0D45_14725	COG2188	Transcriptional regulator
M0D45_14735	COG1609	Transcriptional regulator
M0D45_14740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M0D45_14745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M0D45_14760	COG1215	transferase activity, transferring glycosyl groups
M0D45_14765	COG1649	PFAM Uncharacterised BCR, COG1649
M0D45_14765	COG0726	polysaccharide deacetylase
M0D45_14800	COG0525	valine-tRNA ligase activity
M0D45_14815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M0D45_14825	COG0795	lipopolysaccharide-transporting ATPase activity
M0D45_14845	COG4974	Belongs to the 'phage' integrase family
M0D45_14850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M0D45_14855	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M0D45_14855	COG0047	phosphoribosylformylglycinamidine synthase activity
M0D45_14865	COG5295	Hep Hag repeat protein
M0D45_14870	COG1404	Belongs to the peptidase S8 family
M0D45_14875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M0D45_14880	COG1459	type II secretion system
M0D45_14885	COG2165	general secretion pathway protein
M0D45_14890	COG4970	Tfp pilus assembly protein FimT
M0D45_14895	COG2165	general secretion pathway protein
M0D45_14900	COG4795	General secretion pathway protein
M0D45_14905	COG3156	type II secretion system protein K
M0D45_14910	COG3166	PFAM Fimbrial assembly family protein
M0D45_14925	COG1450	Type ii and iii secretion system protein
M0D45_14935	COG2188	Transcriptional regulator
M0D45_14980	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M0D45_15005	COG0242	peptide deformylase activity
M0D45_15010	COG0488	(ABC) transporter
M0D45_15030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M0D45_15045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M0D45_15045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M0D45_15065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M0D45_15070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M0D45_15075	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M0D45_15095	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M0D45_15100	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M0D45_15110	COG2205	protein histidine kinase activity
M0D45_15115	COG0745	RESPONSE REGULATOR receiver
M0D45_15130	COG0277	FAD linked oxidase domain protein
M0D45_15135	COG1988	membrane-bound metal-dependent
M0D45_15140	COG0792	nuclease activity
M0D45_15180	COG3116	cell division
M0D45_15195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M0D45_15200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M0D45_15210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M0D45_15215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M0D45_15220	COG1181	Belongs to the D-alanine--D-alanine ligase family
M0D45_15225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M0D45_15240	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M0D45_15250	COG0739	heme binding
M0D45_15255	COG0653	protein targeting
M0D45_15265	COG0494	nUDIX hydrolase
M0D45_15275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M0D45_15285	COG0604	alcohol dehydrogenase
M0D45_15285	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_15285	COG3321	synthase
M0D45_15305	COG0366	Alpha amylase catalytic
M0D45_15345	COG2226	methyltransferase
M0D45_15365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M0D45_15405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M0D45_15415	COG4106	trans-aconitate 2-methyltransferase activity
M0D45_15420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M0D45_15435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D45_15440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M0D45_15450	COG0667	Aldo Keto reductase
M0D45_15460	COG4771	TonB-dependent receptor
M0D45_15480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M0D45_15485	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M0D45_15495	COG2175	clavaminate synthase activity
M0D45_15505	COG4181	ATPase activity
M0D45_15520	COG0642	Histidine kinase
M0D45_15530	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M0D45_15550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M0D45_15570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M0D45_15575	COG2967	ApaG domain
M0D45_15580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M0D45_15585	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M0D45_15595	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M0D45_15600	COG0123	including yeast histone deacetylase and acetoin utilization protein
M0D45_15605	COG2096	Adenosyltransferase
M0D45_15620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D45_15625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D45_15630	COG2267	carboxylic ester hydrolase activity
M0D45_15655	COG3384	dioxygenase
M0D45_15660	COG0583	DNA-binding transcription factor activity
M0D45_15665	COG0318	PFAM AMP-dependent synthetase and ligase
M0D45_15675	COG1024	Enoyl-CoA hydratase
M0D45_15720	COG0697	spore germination
M0D45_15725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D45_15745	COG2205	protein histidine kinase activity
M0D45_15745	COG5002	protein histidine kinase activity
M0D45_15745	COG0784	Response regulator, receiver
M0D45_15750	COG2197	response regulator
M0D45_15760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M0D45_15770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M0D45_15775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D45_15785	COG0583	DNA-binding transcription factor activity
M0D45_15790	COG3634	alkyl hydroperoxide reductase activity
M0D45_15800	COG2890	protein-(glutamine-N5) methyltransferase activity
M0D45_15855	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M0D45_15880	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M0D45_15895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M0D45_15900	COG1404	Belongs to the peptidase S8 family
M0D45_15905	COG1404	Belongs to the peptidase S8 family
M0D45_15910	COG1404	Belongs to the peptidase S8 family
M0D45_15915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M0D45_15945	COG1295	ribonuclease BN
M0D45_15950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D45_15970	COG0521	Mo-molybdopterin cofactor biosynthetic process
M0D45_15980	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M0D45_15995	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M0D45_16010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M0D45_16015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M0D45_16020	COG0193	aminoacyl-tRNA hydrolase activity
M0D45_16025	COG0012	GTP binding
M0D45_16045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M0D45_16055	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M0D45_16060	COG0250	Participates in transcription elongation, termination and antitermination
M0D45_16065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M0D45_16070	COG0081	regulation of translation
M0D45_16075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M0D45_16080	COG0222	ribosome binding
M0D45_16085	COG0085	RNA polymerase activity
M0D45_16090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M0D45_16095	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M0D45_16100	COG0049	tRNA binding
M0D45_16105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M0D45_16110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M0D45_16125	COG0051	transcription antitermination factor activity, RNA binding
M0D45_16135	COG0088	Forms part of the polypeptide exit tunnel
M0D45_16145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M0D45_16155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M0D45_16170	COG0255	Belongs to the universal ribosomal protein uL29 family
M0D45_16175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M0D45_16185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M0D45_16205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M0D45_16220	COG1841	ribosomal large subunit assembly
M0D45_16225	COG0200	Binds to the 23S rRNA
M0D45_16230	COG0201	protein transport
M0D45_16255	COG0203	ribosomal protein L17
M0D45_16260	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M0D45_16270	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M0D45_16280	COG0154	amidase activity
M0D45_16290	COG1217	gtp-binding protein TYPA
M0D45_16295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M0D45_16305	COG0625	glutathione transferase activity
M0D45_16320	COG1902	pentaerythritol trinitrate reductase activity
M0D45_16320	COG0446	pyridine nucleotide-disulphide oxidoreductase
M0D45_16325	COG0604	alcohol dehydrogenase
M0D45_16330	COG2885	chlorophyll binding
M0D45_16350	COG0156	8-amino-7-oxononanoate synthase activity
M0D45_16355	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M0D45_16360	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M0D45_16365	COG4208	sulfate ABC transporter
M0D45_16370	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M0D45_16400	COG0406	alpha-ribazole phosphatase activity
M0D45_16415	COG0285	dihydrofolate synthase activity
M0D45_16440	COG2833	Protein of unknown function (DUF455)
M0D45_16445	COG3291	Pkd domain containing protein
M0D45_16455	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D45_16460	COG0671	phosphoesterase, PA-phosphatase related
M0D45_16465	COG0438	transferase activity, transferring glycosyl groups
M0D45_16475	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M0D45_16490	COG4783	chaperone-mediated protein folding
M0D45_16505	COG0473	3-isopropylmalate dehydrogenase activity
M0D45_16545	COG0784	Response regulator, receiver
M0D45_16545	COG4191	Histidine kinase
M0D45_16555	COG0544	peptidyl-prolyl cis-trans isomerase activity
M0D45_16565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M0D45_16595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M0D45_16620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M0D45_16630	COG0631	protein serine/threonine phosphatase activity
M0D45_16645	COG0859	PFAM glycosyl transferase family 9
M0D45_16650	COG3642	lipopolysaccharide core region biosynthetic process
M0D45_16660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M0D45_16670	COG0315	cyclic pyranopterin monophosphate synthase activity
M0D45_16675	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M0D45_16680	COG0314	molybdopterin synthase activity
M0D45_16690	COG0582	viral genome integration into host DNA
M0D45_16880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M0D45_16890	COG0537	adenosine 5'-monophosphoramidase activity
M0D45_16910	COG0714	Associated with various cellular activities
M0D45_16930	COG1399	metal-binding, possibly nucleic acid-binding protein
M0D45_16935	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M0D45_16940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D45_16960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M0D45_16970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M0D45_16975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M0D45_17000	COG3829	transcription factor binding
M0D45_17020	COG3609	addiction module antidote protein, CC2985 family
M0D45_17045	COG2373	Large extracellular alpha-helical protein
M0D45_17060	COG4953	penicillin-binding protein 1C
M0D45_17070	COG0678	peroxiredoxin activity
M0D45_17090	COG0330	HflC and HflK could
M0D45_17095	COG0330	HflC and HflK could
M0D45_17115	COG0308	aminopeptidase N
M0D45_17130	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_17135	COG1309	transcriptional regulator
M0D45_17165	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M0D45_17175	COG0732	type I restriction modification DNA specificity domain
M0D45_17180	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M0D45_17230	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_17240	COG3537	Alpha-1,2-mannosidase
M0D45_17275	COG1064	alcohol dehydrogenase
M0D45_17285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M0D45_17290	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M0D45_17295	COG2080	2 iron, 2 sulfur cluster binding
M0D45_17345	COG0587	DNA-directed DNA polymerase activity
M0D45_17370	COG1297	OPT oligopeptide transporter protein
M0D45_17380	COG1506	peptidase
M0D45_17380	COG0823	Involved in the tonB-independent uptake of proteins
M0D45_17390	COG2207	Transcriptional regulator
M0D45_17390	COG1917	Cupin 2, conserved barrel domain protein
M0D45_17415	COG0753	catalase activity
M0D45_17420	COG0656	L-ascorbic acid biosynthetic process
M0D45_17430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M0D45_17430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M0D45_17455	COG2814	Major facilitator Superfamily
M0D45_17470	COG2194	sulfuric ester hydrolase activity
M0D45_17480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M0D45_17485	COG0745	RESPONSE REGULATOR receiver
M0D45_17490	COG0642	Histidine kinase
M0D45_17500	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M0D45_17505	COG2894	cell division
M0D45_17510	COG0850	regulation of cytokinetic process
M0D45_17520	COG4585	Histidine kinase
M0D45_17525	COG2197	response regulator
M0D45_17540	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M0D45_17555	COG1073	alpha beta
M0D45_17580	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M0D45_17600	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M0D45_17615	COG1595	DNA-templated transcription, initiation
M0D45_17625	COG1946	Acyl-CoA thioesterase
M0D45_17640	COG0824	Thioesterase
M0D45_17645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M0D45_17655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M0D45_17665	COG0268	Binds directly to 16S ribosomal RNA
M0D45_17675	COG0196	riboflavin kinase activity
M0D45_17685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M0D45_17705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M0D45_17710	COG1845	cytochrome c oxidase, subunit III
M0D45_17715	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M0D45_17745	COG2207	Transcriptional regulator
M0D45_17750	COG0326	Molecular chaperone. Has ATPase activity
M0D45_17760	COG1366	Belongs to the anti-sigma-factor antagonist family
M0D45_17765	COG1366	Belongs to the anti-sigma-factor antagonist family
M0D45_17770	COG2172	sigma factor antagonist activity
M0D45_17795	COG4771	TonB-dependent receptor
M0D45_17805	COG5507	3-demethylubiquinone-9 3-methyltransferase
M0D45_17820	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M0D45_17825	COG2205	protein histidine kinase activity
M0D45_17825	COG3437	response regulator, receiver
M0D45_17825	COG3850	Histidine kinase
M0D45_17825	COG4999	Histidine kinase
M0D45_17830	COG0784	Response regulator, receiver
M0D45_17830	COG4191	Histidine kinase
M0D45_17850	COG0583	DNA-binding transcription factor activity
M0D45_17865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M0D45_17870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M0D45_17880	COG2070	2-Nitropropane dioxygenase
M0D45_17890	COG0228	four-way junction DNA binding
M0D45_17895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M0D45_17900	COG0336	Belongs to the RNA methyltransferase TrmD family
M0D45_17910	COG0534	Mate efflux family protein
M0D45_17920	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M0D45_17940	COG4774	siderophore transport
M0D45_17950	COG0523	cobalamin synthesis protein
M0D45_17955	COG0803	Belongs to the bacterial solute-binding protein 9 family
M0D45_17965	COG1121	(ABC) transporter
M0D45_17970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M0D45_17985	COG3250	beta-galactosidase activity
M0D45_18010	COG1960	acyl-CoA dehydrogenase activity
M0D45_18015	COG1024	Enoyl-CoA hydratase
M0D45_18040	COG1024	Enoyl-CoA hydratase
M0D45_18040	COG1250	3-hydroxyacyl-CoA dehydrogenase
M0D45_18055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M0D45_18060	COG0481	GTPase activity
M0D45_18075	COG0571	ribonuclease III activity
M0D45_18085	COG1381	Involved in DNA repair and RecF pathway recombination
M0D45_18100	COG2954	triphosphatase activity
M0D45_18105	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M0D45_18110	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
M0D45_18115	COG3046	protein related to deoxyribodipyrimidine photolyase
M0D45_18120	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D45_18125	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M0D45_18130	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M0D45_18135	COG1278	Cold shock
M0D45_18155	COG1201	RNA secondary structure unwinding
M0D45_18160	COG1793	dna ligase
M0D45_18170	COG1793	dna ligase
M0D45_18170	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M0D45_18200	COG0183	Belongs to the thiolase family
M0D45_18220	COG1451	nucleotide metabolic process
M0D45_18225	COG5487	UPF0391 membrane protein
M0D45_18235	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M0D45_18270	COG1047	Peptidyl-prolyl cis-trans
M0D45_18280	COG2824	Alkylphosphonate utilization operon protein PhnA
M0D45_18285	COG1902	pentaerythritol trinitrate reductase activity
M0D45_18290	COG2814	Major facilitator Superfamily
M0D45_18325	COG0392	lysyltransferase activity
M0D45_18325	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M0D45_18335	COG0251	oxidation-reduction process
M0D45_18340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M0D45_18355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M0D45_18380	COG1595	DNA-templated transcription, initiation
M0D45_18395	COG2878	Part of a membrane complex involved in electron transport
M0D45_18405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D45_18405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D45_18420	COG1131	(ABC) transporter
M0D45_18425	COG0346	lactoylglutathione lyase activity
M0D45_18430	COG0833	amino acid
M0D45_18435	COG2040	homocysteine
M0D45_18455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M0D45_18475	COG1695	Transcriptional regulator
M0D45_18495	COG1981	membrane
M0D45_18515	COG0825	malonyl-CoA metabolic process
M0D45_18530	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D45_18535	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D45_18545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D45_18560	COG0750	zinc metalloprotease
M0D45_18565	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M0D45_18570	COG0575	Belongs to the CDS family
M0D45_18580	COG0233	cytoplasmic translational termination
M0D45_18585	COG0528	UMP kinase activity
M0D45_18595	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M0D45_18640	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M0D45_18655	COG1393	Belongs to the ArsC family
M0D45_18665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D45_18670	COG0367	asparagine synthase
M0D45_18680	COG4774	siderophore transport
M0D45_18685	COG0300	oxidoreductase activity
M0D45_18705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M0D45_18730	COG1566	PFAM secretion protein HlyD family protein
M0D45_18735	COG2814	Major facilitator Superfamily
M0D45_18815	COG0339	signal peptide processing
M0D45_18820	COG0386	Belongs to the glutathione peroxidase family
M0D45_18875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M0D45_18915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M0D45_18920	COG0084	hydrolase, TatD family'
M0D45_18935	COG1960	acyl-CoA dehydrogenase activity
M0D45_18955	COG0367	asparagine synthase
M0D45_18965	COG0305	Participates in initiation and elongation during chromosome replication
M0D45_18970	COG0415	Belongs to the DNA photolyase family
M0D45_18980	COG0583	DNA-binding transcription factor activity
M0D45_18995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D45_19025	COG3706	GGDEF domain
M0D45_19060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M0D45_19070	COG2914	Belongs to the UPF0125 (RnfH) family
M0D45_19075	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D45_19085	COG0497	DNA recombination
M0D45_19090	COG1420	regulation of RNA biosynthetic process
M0D45_19095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M0D45_19100	COG0443	Heat shock 70 kDa protein
M0D45_19115	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M0D45_19145	COG0583	DNA-binding transcription factor activity
M0D45_19155	COG1132	(ABC) transporter
M0D45_19195	COG2850	peptidyl-arginine hydroxylation
M0D45_19220	COG1253	flavin adenine dinucleotide binding
M0D45_19255	COG1131	(ABC) transporter
M0D45_19260	COG1725	Transcriptional regulator
M0D45_19270	COG0386	Belongs to the glutathione peroxidase family
M0D45_19285	COG2900	Belongs to the SlyX family
M0D45_19310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D45_19320	COG1410	methionine synthase
M0D45_19320	COG0646	methionine synthase
M0D45_19330	COG1410	methionine synthase
M0D45_19330	COG0646	methionine synthase
M0D45_19335	COG2226	methyltransferase
M0D45_19340	COG1960	acyl-CoA dehydrogenase activity
M0D45_19355	COG0557	exoribonuclease II activity
M0D45_19365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M0D45_19375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M0D45_19385	COG0704	Plays a role in the regulation of phosphate uptake
M0D45_19395	COG0581	inorganic phosphate transmembrane transporter activity
M0D45_19400	COG0573	inorganic phosphate transmembrane transporter activity
M0D45_19405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M0D45_19430	COG0659	secondary active sulfate transmembrane transporter activity
M0D45_19435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M0D45_19445	COG1024	Enoyl-CoA hydratase
M0D45_19495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M0D45_19495	COG0116	Belongs to the methyltransferase superfamily
M0D45_19500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M0D45_19515	COG0667	Aldo Keto reductase
M0D45_19525	COG2925	Exonuclease
M0D45_19530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D45_19535	COG3844	kynureninase activity
M0D45_19550	COG0288	reversible hydration of carbon dioxide
M0D45_19575	COG0017	Asparaginyl-tRNA synthetase
M0D45_19580	COG0316	Belongs to the HesB IscA family
M0D45_19585	COG0360	Binds together with S18 to 16S ribosomal RNA
M0D45_19605	COG3115	cell septum assembly
M0D45_19615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D45_19620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M0D45_19625	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M0D45_19640	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M0D45_19655	COG4993	Dehydrogenase
M0D45_19670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M0D45_19680	COG2986	histidine ammonia-lyase
M0D45_19685	COG1228	amidohydrolase
M0D45_19720	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
M0D45_19725	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M0D45_19730	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M0D45_19735	COG1605	Chorismate mutase
M0D45_19735	COG0077	Prephenate dehydratase
M0D45_19740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M0D45_19755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M0D45_19760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M0D45_19765	COG0583	DNA-binding transcription factor activity
M0D45_19820	COG0840	transmembrane signaling receptor activity
M0D45_19840	COG5002	protein histidine kinase activity
M0D45_19840	COG0784	Response regulator, receiver
M0D45_19840	COG2205	protein histidine kinase activity
M0D45_19845	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M0D45_19850	COG4191	Histidine kinase
M0D45_19850	COG0784	Response regulator, receiver
M0D45_19865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D45_19875	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M0D45_19885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M0D45_19900	COG1595	DNA-templated transcription, initiation
M0D45_19950	COG2244	polysaccharide biosynthetic process
M0D45_19975	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M0D45_19980	COG2264	protein methyltransferase activity
M0D45_19990	COG0438	transferase activity, transferring glycosyl groups
M0D45_20005	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M0D45_20010	COG1132	(ABC) transporter
M0D45_20015	COG2271	Major facilitator Superfamily
M0D45_20020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M0D45_20035	COG1253	flavin adenine dinucleotide binding
M0D45_20045	COG0306	phosphate transporter
M0D45_20050	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M0D45_20070	COG0504	CTP synthase activity
M0D45_20085	COG0148	phosphopyruvate hydratase activity
M0D45_20090	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M0D45_20100	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M0D45_20105	COG0585	pseudouridine synthase activity
M0D45_20110	COG2840	Smr protein MutS2
M0D45_20115	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M0D45_20120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M0D45_20125	COG1238	metal cluster binding
M0D45_20135	COG3737	Protein of unknown function (DUF498/DUF598)
M0D45_20140	COG1534	Rna-binding protein
M0D45_20145	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M0D45_20150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M0D45_20155	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M0D45_20160	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M0D45_20170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M0D45_20175	COG1546	Belongs to the CinA family
M0D45_20180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D45_20190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M0D45_20195	COG2137	regulation of response to DNA damage stimulus
M0D45_20200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M0D45_20205	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M0D45_20225	COG1741	Belongs to the pirin family
M0D45_20230	COG0583	DNA-binding transcription factor activity
M0D45_20255	COG0352	thiamine-phosphate diphosphorylase activity
M0D45_20255	COG0351	phosphomethylpyrimidine kinase
M0D45_20270	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M0D45_20275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M0D45_20290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M0D45_20300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M0D45_20305	COG3734	2-keto-3-deoxy-galactonokinase
M0D45_20315	COG4948	Mandelate Racemase Muconate Lactonizing
M0D45_20320	COG0800	Aldolase
M0D45_20360	COG1501	Belongs to the glycosyl hydrolase 31 family
M0D45_20370	COG1070	Carbohydrate kinase
M0D45_20380	COG0477	Major facilitator Superfamily
M0D45_20400	COG0860	N-Acetylmuramoyl-L-alanine amidase
M0D45_20405	COG1469	GTP cyclohydrolase I activity
M0D45_20415	COG0617	tRNA 3'-terminal CCA addition
M0D45_20425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M0D45_20430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M0D45_20435	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M0D45_20440	COG0166	Belongs to the GPI family
M0D45_20465	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D45_20475	COG4251	negative regulation of phosphorylation
M0D45_20475	COG2203	Gaf domain
M0D45_20475	COG3706	GGDEF domain
M0D45_20475	COG5001	Diguanylate cyclase
M0D45_20480	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D45_20485	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
M0D45_20500	COG0671	phosphoesterase, PA-phosphatase related
M0D45_20510	COG1794	racemase activity, acting on amino acids and derivatives
M0D45_20515	COG0697	spore germination
M0D45_20520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M0D45_20525	COG0167	dihydroorotate dehydrogenase activity
M0D45_20540	COG1012	belongs to the aldehyde dehydrogenase family
M0D45_20570	COG2801	Transposase and inactivated derivatives
M0D45_20610	COG1074	ATP-dependent DNA helicase activity
M0D45_20675	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
M0D45_20675	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
M0D45_20740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M0D45_20750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M0D45_20755	COG0124	histidyl-tRNA synthetase
M0D45_20770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M0D45_20775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D45_20780	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M0D45_20780	COG0131	Imidazoleglycerol-phosphate dehydratase
M0D45_20785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M0D45_20790	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M0D45_20795	COG0107	imidazoleglycerol-phosphate synthase activity
M0D45_20800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M0D45_20800	COG0140	phosphoribosyl-ATP diphosphatase activity
M0D45_20820	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M0D45_20825	COG0235	Class ii aldolase
M0D45_20830	COG0531	amino acid
M0D45_20835	COG0531	amino acid
M0D45_20845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M0D45_20850	COG0277	FAD linked oxidase domain protein
M0D45_20870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M0D45_20915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M0D45_20920	COG2258	MOSC domain
M0D45_20930	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M0D45_20935	COG0505	Belongs to the CarA family
M0D45_20945	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M0D45_20950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D45_20960	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M0D45_20975	COG3279	Response regulator of the LytR AlgR family
M0D45_20985	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M0D45_20995	COG2205	protein histidine kinase activity
M0D45_20995	COG2198	Histidine kinase
M0D45_20995	COG0784	Response regulator, receiver
M0D45_21000	COG1024	Enoyl-CoA hydratase
M0D45_21005	COG0318	PFAM AMP-dependent synthetase and ligase
M0D45_21035	COG2267	carboxylic ester hydrolase activity
M0D45_21065	COG0840	transmembrane signaling receptor activity
M0D45_21075	COG0835	chemotaxis
M0D45_21085	COG0840	transmembrane signaling receptor activity
M0D45_21090	COG0840	transmembrane signaling receptor activity
M0D45_21095	COG0840	transmembrane signaling receptor activity
M0D45_21100	COG0840	transmembrane signaling receptor activity
M0D45_21105	COG0840	transmembrane signaling receptor activity
M0D45_21110	COG0840	transmembrane signaling receptor activity
M0D45_21115	COG0840	transmembrane signaling receptor activity
M0D45_21120	COG0840	transmembrane signaling receptor activity
M0D45_21125	COG0840	transmembrane signaling receptor activity
M0D45_21135	COG0840	transmembrane signaling receptor activity
M0D45_21150	COG0840	transmembrane signaling receptor activity
M0D45_21160	COG0745	RESPONSE REGULATOR receiver
M0D45_21170	COG0835	chemotaxis
M0D45_21175	COG1192	Involved in chromosome partitioning
M0D45_21180	COG1360	Flagellar Motor Protein
M0D45_21185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M0D45_21190	COG0793	Belongs to the peptidase S41A family
M0D45_21275	COG2198	Histidine kinase
M0D45_21275	COG0784	Response regulator, receiver
M0D45_21275	COG0643	Histidine kinase
M0D45_21330	COG1684	flagellar biosynthetic protein fliR
M0D45_21345	COG3190	flagellar
M0D45_21395	COG1677	Flagellar hook-basal body complex protein FliE
M0D45_21455	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_21460	COG1028	Short-chain dehydrogenase reductase Sdr
M0D45_21465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D45_21485	COG2201	protein-glutamate methylesterase activity
M0D45_21515	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M0D45_21520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M0D45_21525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M0D45_21535	COG1705	Flagellar rod assembly protein muramidase FlgJ
M0D45_21535	COG3951	Flagellar rod assembly protein muramidase FlgJ
M0D45_21540	COG1706	bacterial-type flagellum-dependent cell motility
M0D45_21545	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M0D45_21555	COG4787	bacterial-type flagellum-dependent cell motility
M0D45_21565	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M0D45_21570	COG1558	bacterial-type flagellum-dependent cell motility
M0D45_21580	COG0784	Response regulator, receiver
M0D45_21580	COG0835	chemotaxis
M0D45_21600	COG5002	protein histidine kinase activity
M0D45_21610	COG4585	Histidine kinase
M0D45_21640	COG0482	sulfurtransferase activity
M0D45_21660	COG0542	response to heat
M0D45_21670	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M0D45_21680	COG0492	ferredoxin-NADP+ reductase activity
M0D45_21685	COG1674	ftsk spoiiie
M0D45_21705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M0D45_21710	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M0D45_21715	COG0183	Belongs to the thiolase family
M0D45_21720	COG1024	Enoyl-CoA hydratase
M0D45_21720	COG1250	3-hydroxyacyl-CoA dehydrogenase
M0D45_21735	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M0D45_21760	COG1160	GTP binding
M0D45_21765	COG0303	'Molybdopterin
M0D45_21770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M0D45_21780	COG0708	Exodeoxyribonuclease III
M0D45_21790	COG0303	'Molybdopterin
M0D45_21795	COG0746	molybdenum cofactor guanylyltransferase activity
M0D45_21805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M0D45_21805	COG1648	precorrin-2 dehydrogenase activity
M0D45_21815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M0D45_21820	COG2223	nitrite transmembrane transporter activity
M0D45_21825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M0D45_21835	COG0243	molybdopterin cofactor binding
M0D45_21870	COG5001	Diguanylate cyclase
M0D45_21880	COG4566	intracellular signal transduction
M0D45_21910	COG3275	phosphorelay sensor kinase activity
M0D45_21915	COG3279	Response regulator of the LytR AlgR family
M0D45_21945	COG1238	metal cluster binding
M0D45_21960	COG0363	glucosamine-6-phosphate deaminase activity
M0D45_21980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family