locus-tag	class	description
M0D44_00030	COG1304	FMN binding
M0D44_00035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M0D44_00055	COG0363	glucosamine-6-phosphate deaminase activity
M0D44_00075	COG1238	metal cluster binding
M0D44_00105	COG3279	Response regulator of the LytR AlgR family
M0D44_00110	COG3275	phosphorelay sensor kinase activity
M0D44_00140	COG4566	intracellular signal transduction
M0D44_00150	COG5001	Diguanylate cyclase
M0D44_00180	COG0243	molybdopterin cofactor binding
M0D44_00190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M0D44_00195	COG2223	nitrite transmembrane transporter activity
M0D44_00200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M0D44_00210	COG1648	precorrin-2 dehydrogenase activity
M0D44_00210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M0D44_00220	COG0746	molybdenum cofactor guanylyltransferase activity
M0D44_00225	COG0303	'Molybdopterin
M0D44_00235	COG0708	Exodeoxyribonuclease III
M0D44_00245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M0D44_00250	COG0303	'Molybdopterin
M0D44_00255	COG1160	GTP binding
M0D44_00280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M0D44_00295	COG1024	Enoyl-CoA hydratase
M0D44_00295	COG1250	3-hydroxyacyl-CoA dehydrogenase
M0D44_00300	COG0183	Belongs to the thiolase family
M0D44_00305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M0D44_00310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M0D44_00330	COG1674	ftsk spoiiie
M0D44_00335	COG0492	ferredoxin-NADP+ reductase activity
M0D44_00345	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M0D44_00355	COG0542	response to heat
M0D44_00375	COG0482	sulfurtransferase activity
M0D44_00405	COG4585	Histidine kinase
M0D44_00415	COG5002	protein histidine kinase activity
M0D44_00435	COG0784	Response regulator, receiver
M0D44_00435	COG0835	chemotaxis
M0D44_00445	COG1558	bacterial-type flagellum-dependent cell motility
M0D44_00450	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M0D44_00460	COG4787	bacterial-type flagellum-dependent cell motility
M0D44_00470	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M0D44_00475	COG1706	bacterial-type flagellum-dependent cell motility
M0D44_00480	COG1705	Flagellar rod assembly protein muramidase FlgJ
M0D44_00480	COG3951	Flagellar rod assembly protein muramidase FlgJ
M0D44_00490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M0D44_00495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M0D44_00500	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M0D44_00530	COG2201	protein-glutamate methylesterase activity
M0D44_00550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D44_00555	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_00560	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_00620	COG1677	Flagellar hook-basal body complex protein FliE
M0D44_00670	COG3190	flagellar
M0D44_00685	COG1684	flagellar biosynthetic protein fliR
M0D44_00740	COG0643	Histidine kinase
M0D44_00740	COG0784	Response regulator, receiver
M0D44_00740	COG2198	Histidine kinase
M0D44_00825	COG0793	Belongs to the peptidase S41A family
M0D44_00830	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M0D44_00835	COG1360	Flagellar Motor Protein
M0D44_00840	COG1192	Involved in chromosome partitioning
M0D44_00845	COG0835	chemotaxis
M0D44_00855	COG0745	RESPONSE REGULATOR receiver
M0D44_00875	COG0840	transmembrane signaling receptor activity
M0D44_00880	COG0840	transmembrane signaling receptor activity
M0D44_00890	COG0840	transmembrane signaling receptor activity
M0D44_00895	COG0840	transmembrane signaling receptor activity
M0D44_00900	COG0840	transmembrane signaling receptor activity
M0D44_00905	COG0840	transmembrane signaling receptor activity
M0D44_00910	COG0840	transmembrane signaling receptor activity
M0D44_00925	COG0840	transmembrane signaling receptor activity
M0D44_00940	COG0835	chemotaxis
M0D44_00950	COG0840	transmembrane signaling receptor activity
M0D44_00980	COG2267	carboxylic ester hydrolase activity
M0D44_01010	COG0318	PFAM AMP-dependent synthetase and ligase
M0D44_01015	COG1024	Enoyl-CoA hydratase
M0D44_01020	COG2205	protein histidine kinase activity
M0D44_01020	COG2198	Histidine kinase
M0D44_01020	COG0784	Response regulator, receiver
M0D44_01030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M0D44_01040	COG3279	Response regulator of the LytR AlgR family
M0D44_01055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M0D44_01065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D44_01070	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M0D44_01080	COG0505	Belongs to the CarA family
M0D44_01085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M0D44_01095	COG2258	MOSC domain
M0D44_01100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M0D44_01145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M0D44_01165	COG0277	FAD linked oxidase domain protein
M0D44_01170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M0D44_01180	COG0531	amino acid
M0D44_01185	COG0531	amino acid
M0D44_01190	COG0235	Class ii aldolase
M0D44_01195	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M0D44_01215	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M0D44_01215	COG0140	phosphoribosyl-ATP diphosphatase activity
M0D44_01220	COG0107	imidazoleglycerol-phosphate synthase activity
M0D44_01225	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M0D44_01230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M0D44_01235	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M0D44_01235	COG0131	Imidazoleglycerol-phosphate dehydratase
M0D44_01240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D44_01245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M0D44_01260	COG0124	histidyl-tRNA synthetase
M0D44_01270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M0D44_01280	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M0D44_01355	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
M0D44_01355	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
M0D44_01380	COG2814	Major facilitator Superfamily
M0D44_01515	COG2003	Belongs to the UPF0758 family
M0D44_01545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M0D44_01555	COG3621	Patatin-like phospholipase
M0D44_01585	COG1012	belongs to the aldehyde dehydrogenase family
M0D44_01600	COG0167	dihydroorotate dehydrogenase activity
M0D44_01605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M0D44_01610	COG0697	spore germination
M0D44_01615	COG1794	racemase activity, acting on amino acids and derivatives
M0D44_01625	COG0671	phosphoesterase, PA-phosphatase related
M0D44_01630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M0D44_01640	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
M0D44_01645	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D44_01650	COG2203	Gaf domain
M0D44_01650	COG4251	negative regulation of phosphorylation
M0D44_01650	COG5001	Diguanylate cyclase
M0D44_01650	COG3706	GGDEF domain
M0D44_01660	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D44_01690	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M0D44_01695	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M0D44_01700	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M0D44_01710	COG0617	tRNA 3'-terminal CCA addition
M0D44_01720	COG1469	GTP cyclohydrolase I activity
M0D44_01725	COG0860	N-Acetylmuramoyl-L-alanine amidase
M0D44_01745	COG0477	Major facilitator Superfamily
M0D44_01755	COG1070	Carbohydrate kinase
M0D44_01765	COG1501	Belongs to the glycosyl hydrolase 31 family
M0D44_01810	COG0800	Aldolase
M0D44_01815	COG4948	Mandelate Racemase Muconate Lactonizing
M0D44_01825	COG3734	2-keto-3-deoxy-galactonokinase
M0D44_01830	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M0D44_01840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M0D44_01855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M0D44_01860	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M0D44_01875	COG0351	phosphomethylpyrimidine kinase
M0D44_01875	COG0352	thiamine-phosphate diphosphorylase activity
M0D44_01900	COG0583	DNA-binding transcription factor activity
M0D44_01905	COG1741	Belongs to the pirin family
M0D44_01920	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M0D44_01925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M0D44_01930	COG2137	regulation of response to DNA damage stimulus
M0D44_01935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M0D44_01945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D44_01950	COG1546	Belongs to the CinA family
M0D44_01955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M0D44_01965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M0D44_01970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M0D44_01975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M0D44_01980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M0D44_01985	COG1534	Rna-binding protein
M0D44_01990	COG3737	Protein of unknown function (DUF498/DUF598)
M0D44_02000	COG1238	metal cluster binding
M0D44_02005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M0D44_02010	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M0D44_02015	COG2840	Smr protein MutS2
M0D44_02020	COG0585	pseudouridine synthase activity
M0D44_02025	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M0D44_02035	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M0D44_02040	COG0148	phosphopyruvate hydratase activity
M0D44_02055	COG0504	CTP synthase activity
M0D44_02075	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M0D44_02080	COG0306	phosphate transporter
M0D44_02090	COG1253	flavin adenine dinucleotide binding
M0D44_02105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M0D44_02110	COG0477	Major facilitator Superfamily
M0D44_02115	COG1132	(ABC) transporter
M0D44_02120	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M0D44_02135	COG0438	transferase activity, transferring glycosyl groups
M0D44_02145	COG2264	protein methyltransferase activity
M0D44_02150	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M0D44_02175	COG2244	polysaccharide biosynthetic process
M0D44_02240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M0D44_02250	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M0D44_02260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D44_02275	COG4191	Histidine kinase
M0D44_02275	COG0784	Response regulator, receiver
M0D44_02280	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M0D44_02285	COG0784	Response regulator, receiver
M0D44_02285	COG2205	protein histidine kinase activity
M0D44_02285	COG5002	protein histidine kinase activity
M0D44_02305	COG0840	transmembrane signaling receptor activity
M0D44_02395	COG2003	Belongs to the UPF0758 family
M0D44_02480	COG0583	DNA-binding transcription factor activity
M0D44_02485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M0D44_02490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M0D44_02505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M0D44_02510	COG1605	Chorismate mutase
M0D44_02510	COG0077	Prephenate dehydratase
M0D44_02515	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M0D44_02520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M0D44_02525	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
M0D44_02560	COG1228	amidohydrolase
M0D44_02565	COG2986	histidine ammonia-lyase
M0D44_02575	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M0D44_02590	COG4993	Dehydrogenase
M0D44_02605	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M0D44_02620	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M0D44_02625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M0D44_02630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D44_02640	COG3115	cell septum assembly
M0D44_02660	COG0360	Binds together with S18 to 16S ribosomal RNA
M0D44_02665	COG0316	Belongs to the HesB IscA family
M0D44_02670	COG0017	Asparaginyl-tRNA synthetase
M0D44_02695	COG0288	reversible hydration of carbon dioxide
M0D44_02710	COG3844	kynureninase activity
M0D44_02715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D44_02720	COG2925	Exonuclease
M0D44_02730	COG0667	Aldo Keto reductase
M0D44_02745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M0D44_02750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M0D44_02750	COG0116	Belongs to the methyltransferase superfamily
M0D44_02800	COG1024	Enoyl-CoA hydratase
M0D44_02810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M0D44_02815	COG0659	secondary active sulfate transmembrane transporter activity
M0D44_02840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M0D44_02845	COG0573	inorganic phosphate transmembrane transporter activity
M0D44_02850	COG0581	inorganic phosphate transmembrane transporter activity
M0D44_02860	COG0704	Plays a role in the regulation of phosphate uptake
M0D44_02870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M0D44_02880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M0D44_02890	COG0557	exoribonuclease II activity
M0D44_02905	COG1960	acyl-CoA dehydrogenase activity
M0D44_02910	COG2226	methyltransferase
M0D44_02915	COG0646	methionine synthase
M0D44_02915	COG1410	methionine synthase
M0D44_02925	COG0646	methionine synthase
M0D44_02925	COG1410	methionine synthase
M0D44_02935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D44_02960	COG2900	Belongs to the SlyX family
M0D44_02975	COG0386	Belongs to the glutathione peroxidase family
M0D44_02985	COG1725	Transcriptional regulator
M0D44_02990	COG1131	(ABC) transporter
M0D44_03025	COG1253	flavin adenine dinucleotide binding
M0D44_03050	COG2850	peptidyl-arginine hydroxylation
M0D44_03090	COG1132	(ABC) transporter
M0D44_03100	COG0583	DNA-binding transcription factor activity
M0D44_03130	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M0D44_03145	COG0443	Heat shock 70 kDa protein
M0D44_03150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M0D44_03155	COG1420	regulation of RNA biosynthetic process
M0D44_03160	COG0497	DNA recombination
M0D44_03170	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D44_03175	COG2914	Belongs to the UPF0125 (RnfH) family
M0D44_03185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M0D44_03250	COG3706	GGDEF domain
M0D44_03280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D44_03295	COG0583	DNA-binding transcription factor activity
M0D44_03305	COG0415	Belongs to the DNA photolyase family
M0D44_03310	COG0305	Participates in initiation and elongation during chromosome replication
M0D44_03320	COG0367	asparagine synthase
M0D44_03340	COG1960	acyl-CoA dehydrogenase activity
M0D44_03355	COG0084	hydrolase, TatD family'
M0D44_03360	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M0D44_03400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M0D44_03455	COG0386	Belongs to the glutathione peroxidase family
M0D44_03460	COG0339	signal peptide processing
M0D44_03540	COG2814	Major facilitator Superfamily
M0D44_03545	COG1566	PFAM secretion protein HlyD family protein
M0D44_03570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M0D44_03590	COG0300	oxidoreductase activity
M0D44_03595	COG4774	siderophore transport
M0D44_03605	COG0367	asparagine synthase
M0D44_03610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D44_03620	COG1393	Belongs to the ArsC family
M0D44_03635	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M0D44_03680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M0D44_03690	COG0528	UMP kinase activity
M0D44_03695	COG0233	cytoplasmic translational termination
M0D44_03705	COG0575	Belongs to the CDS family
M0D44_03710	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M0D44_03715	COG0750	zinc metalloprotease
M0D44_03730	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D44_03740	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D44_03745	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D44_03750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M0D44_03785	COG1981	membrane
M0D44_03805	COG1695	Transcriptional regulator
M0D44_03825	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M0D44_03845	COG2040	homocysteine
M0D44_03850	COG0833	amino acid
M0D44_03855	COG0346	lactoylglutathione lyase activity
M0D44_03860	COG1131	(ABC) transporter
M0D44_03875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D44_03875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D44_03885	COG2878	Part of a membrane complex involved in electron transport
M0D44_03900	COG1595	DNA-templated transcription, initiation
M0D44_03925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M0D44_03940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M0D44_03945	COG0251	oxidation-reduction process
M0D44_03955	COG0392	lysyltransferase activity
M0D44_03955	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M0D44_03990	COG2814	Major facilitator Superfamily
M0D44_03995	COG1902	pentaerythritol trinitrate reductase activity
M0D44_04000	COG2824	Alkylphosphonate utilization operon protein PhnA
M0D44_04010	COG1047	Peptidyl-prolyl cis-trans
M0D44_04045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M0D44_04055	COG5487	UPF0391 membrane protein
M0D44_04060	COG1451	nucleotide metabolic process
M0D44_04085	COG0183	Belongs to the thiolase family
M0D44_04115	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M0D44_04115	COG1793	dna ligase
M0D44_04125	COG1793	dna ligase
M0D44_04130	COG1201	RNA secondary structure unwinding
M0D44_04145	COG1278	Cold shock
M0D44_04150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M0D44_04155	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M0D44_04160	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D44_04165	COG3046	protein related to deoxyribodipyrimidine photolyase
M0D44_04170	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
M0D44_04175	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M0D44_04180	COG2954	triphosphatase activity
M0D44_04195	COG1381	Involved in DNA repair and RecF pathway recombination
M0D44_04205	COG0571	ribonuclease III activity
M0D44_04220	COG0481	GTPase activity
M0D44_04225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M0D44_04265	COG1024	Enoyl-CoA hydratase
M0D44_04270	COG1960	acyl-CoA dehydrogenase activity
M0D44_04290	COG3867	Arabinogalactan endo-beta-1,4-galactanase
M0D44_04295	COG3250	beta-galactosidase activity
M0D44_04310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M0D44_04315	COG1121	(ABC) transporter
M0D44_04325	COG0803	Belongs to the bacterial solute-binding protein 9 family
M0D44_04330	COG0523	cobalamin synthesis protein
M0D44_04340	COG4774	siderophore transport
M0D44_04360	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M0D44_04370	COG0534	Mate efflux family protein
M0D44_04380	COG0336	Belongs to the RNA methyltransferase TrmD family
M0D44_04385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M0D44_04390	COG0228	four-way junction DNA binding
M0D44_04400	COG2070	2-Nitropropane dioxygenase
M0D44_04410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M0D44_04415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M0D44_04430	COG0583	DNA-binding transcription factor activity
M0D44_04450	COG0784	Response regulator, receiver
M0D44_04450	COG4191	Histidine kinase
M0D44_04455	COG4999	Histidine kinase
M0D44_04455	COG3850	Histidine kinase
M0D44_04455	COG3437	response regulator, receiver
M0D44_04455	COG2205	protein histidine kinase activity
M0D44_04460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M0D44_04475	COG5507	3-demethylubiquinone-9 3-methyltransferase
M0D44_04485	COG4771	TonB-dependent receptor
M0D44_04510	COG2172	sigma factor antagonist activity
M0D44_04515	COG1366	Belongs to the anti-sigma-factor antagonist family
M0D44_04520	COG1366	Belongs to the anti-sigma-factor antagonist family
M0D44_04530	COG0326	Molecular chaperone. Has ATPase activity
M0D44_04535	COG2207	Transcriptional regulator
M0D44_04545	COG3152	Membrane
M0D44_04555	COG0156	8-amino-7-oxononanoate synthase activity
M0D44_04565	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M0D44_04570	COG1845	cytochrome c oxidase, subunit III
M0D44_04575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M0D44_04595	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M0D44_04600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M0D44_04615	COG0268	Binds directly to 16S ribosomal RNA
M0D44_04625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M0D44_04635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M0D44_04640	COG0824	Thioesterase
M0D44_04655	COG1946	Acyl-CoA thioesterase
M0D44_04665	COG1595	DNA-templated transcription, initiation
M0D44_04680	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M0D44_04700	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M0D44_04725	COG1073	alpha beta
M0D44_04745	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M0D44_04760	COG2197	response regulator
M0D44_04765	COG4585	Histidine kinase
M0D44_04780	COG2894	cell division
M0D44_04785	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M0D44_04795	COG0642	Histidine kinase
M0D44_04800	COG0745	RESPONSE REGULATOR receiver
M0D44_04805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M0D44_04815	COG2194	sulfuric ester hydrolase activity
M0D44_04830	COG2814	Major facilitator Superfamily
M0D44_04855	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M0D44_04855	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M0D44_04865	COG0656	L-ascorbic acid biosynthetic process
M0D44_04870	COG0753	catalase activity
M0D44_04895	COG1917	Cupin 2, conserved barrel domain protein
M0D44_04895	COG2207	Transcriptional regulator
M0D44_04905	COG1506	peptidase
M0D44_04905	COG0823	Involved in the tonB-independent uptake of proteins
M0D44_04915	COG1297	OPT oligopeptide transporter protein
M0D44_04940	COG0587	DNA-directed DNA polymerase activity
M0D44_04990	COG2080	2 iron, 2 sulfur cluster binding
M0D44_04995	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M0D44_05000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M0D44_05010	COG1064	alcohol dehydrogenase
M0D44_05045	COG3537	Alpha-1,2-mannosidase
M0D44_05055	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_05095	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
M0D44_05105	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M0D44_05110	COG0732	type I restriction modification DNA specificity domain
M0D44_05125	COG1309	transcriptional regulator
M0D44_05130	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_05145	COG0308	aminopeptidase N
M0D44_05165	COG0330	HflC and HflK could
M0D44_05170	COG0330	HflC and HflK could
M0D44_05190	COG0678	peroxiredoxin activity
M0D44_05200	COG4953	penicillin-binding protein 1C
M0D44_05215	COG2373	Large extracellular alpha-helical protein
M0D44_05240	COG3609	addiction module antidote protein, CC2985 family
M0D44_05260	COG3829	transcription factor binding
M0D44_05285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M0D44_05290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M0D44_05300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M0D44_05320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D44_05325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M0D44_05330	COG1399	metal-binding, possibly nucleic acid-binding protein
M0D44_05350	COG0714	Associated with various cellular activities
M0D44_05370	COG0537	adenosine 5'-monophosphoramidase activity
M0D44_05380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M0D44_05400	COG0314	molybdopterin synthase activity
M0D44_05405	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M0D44_05410	COG0315	cyclic pyranopterin monophosphate synthase activity
M0D44_05420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M0D44_05430	COG3642	lipopolysaccharide core region biosynthetic process
M0D44_05435	COG0859	PFAM glycosyl transferase family 9
M0D44_05450	COG0631	protein serine/threonine phosphatase activity
M0D44_05460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M0D44_05485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M0D44_05515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M0D44_05525	COG0544	peptidyl-prolyl cis-trans isomerase activity
M0D44_05535	COG0784	Response regulator, receiver
M0D44_05535	COG4191	Histidine kinase
M0D44_05575	COG0473	3-isopropylmalate dehydrogenase activity
M0D44_05590	COG4783	chaperone-mediated protein folding
M0D44_05605	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M0D44_05615	COG0438	transferase activity, transferring glycosyl groups
M0D44_05620	COG0671	phosphoesterase, PA-phosphatase related
M0D44_05625	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M0D44_05635	COG3291	Pkd domain containing protein
M0D44_05640	COG2833	Protein of unknown function (DUF455)
M0D44_05665	COG0285	dihydrofolate synthase activity
M0D44_05680	COG0406	alpha-ribazole phosphatase activity
M0D44_05710	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M0D44_05715	COG4208	sulfate ABC transporter
M0D44_05720	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M0D44_05725	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M0D44_05730	COG0156	8-amino-7-oxononanoate synthase activity
M0D44_05750	COG2885	chlorophyll binding
M0D44_05755	COG0604	alcohol dehydrogenase
M0D44_05760	COG0446	pyridine nucleotide-disulphide oxidoreductase
M0D44_05760	COG1902	pentaerythritol trinitrate reductase activity
M0D44_05775	COG0625	glutathione transferase activity
M0D44_05785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M0D44_05790	COG1217	gtp-binding protein TYPA
M0D44_05800	COG0154	amidase activity
M0D44_05810	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M0D44_05820	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M0D44_05825	COG0203	ribosomal protein L17
M0D44_05850	COG0201	protein transport
M0D44_05855	COG0200	Binds to the 23S rRNA
M0D44_05860	COG1841	ribosomal large subunit assembly
M0D44_05875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M0D44_05895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M0D44_05905	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M0D44_05910	COG0255	Belongs to the universal ribosomal protein uL29 family
M0D44_05925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M0D44_05935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M0D44_05945	COG0088	Forms part of the polypeptide exit tunnel
M0D44_05955	COG0051	transcription antitermination factor activity, RNA binding
M0D44_05970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M0D44_05975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M0D44_05980	COG0049	tRNA binding
M0D44_05985	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M0D44_05990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M0D44_05995	COG0085	RNA polymerase activity
M0D44_06005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M0D44_06010	COG0081	regulation of translation
M0D44_06015	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M0D44_06020	COG0250	Participates in transcription elongation, termination and antitermination
M0D44_06025	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M0D44_06035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M0D44_06055	COG0012	GTP binding
M0D44_06060	COG0193	aminoacyl-tRNA hydrolase activity
M0D44_06065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M0D44_06070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M0D44_06085	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M0D44_06095	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M0D44_06100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M0D44_06110	COG0521	Mo-molybdopterin cofactor biosynthetic process
M0D44_06130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D44_06135	COG1295	ribonuclease BN
M0D44_06165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M0D44_06170	COG1404	Belongs to the peptidase S8 family
M0D44_06175	COG1404	Belongs to the peptidase S8 family
M0D44_06180	COG1404	Belongs to the peptidase S8 family
M0D44_06185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M0D44_06200	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M0D44_06225	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M0D44_06290	COG3634	alkyl hydroperoxide reductase activity
M0D44_06295	COG0583	DNA-binding transcription factor activity
M0D44_06305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D44_06310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M0D44_06320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M0D44_06330	COG2197	response regulator
M0D44_06335	COG5002	protein histidine kinase activity
M0D44_06335	COG2205	protein histidine kinase activity
M0D44_06335	COG0784	Response regulator, receiver
M0D44_06355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D44_06360	COG0697	spore germination
M0D44_06405	COG1024	Enoyl-CoA hydratase
M0D44_06415	COG0318	PFAM AMP-dependent synthetase and ligase
M0D44_06420	COG0583	DNA-binding transcription factor activity
M0D44_06425	COG3384	dioxygenase
M0D44_06435	COG1802	Transcriptional regulator
M0D44_06450	COG2267	carboxylic ester hydrolase activity
M0D44_06455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D44_06460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M0D44_06475	COG2096	Adenosyltransferase
M0D44_06480	COG0123	including yeast histone deacetylase and acetoin utilization protein
M0D44_06485	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M0D44_06495	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M0D44_06500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M0D44_06505	COG2967	ApaG domain
M0D44_06510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M0D44_06530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M0D44_06550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M0D44_06560	COG0642	Histidine kinase
M0D44_06575	COG4181	ATPase activity
M0D44_06585	COG2175	clavaminate synthase activity
M0D44_06595	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M0D44_06600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M0D44_06620	COG4771	TonB-dependent receptor
M0D44_06630	COG0667	Aldo Keto reductase
M0D44_06635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M0D44_06640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D44_06655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M0D44_06660	COG4106	trans-aconitate 2-methyltransferase activity
M0D44_06670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M0D44_06710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M0D44_06725	COG2226	methyltransferase
M0D44_06765	COG0366	Alpha amylase catalytic
M0D44_06785	COG3321	synthase
M0D44_06785	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_06785	COG0604	alcohol dehydrogenase
M0D44_06795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M0D44_06805	COG0494	nUDIX hydrolase
M0D44_06815	COG0653	protein targeting
M0D44_06820	COG0739	heme binding
M0D44_06830	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M0D44_06845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M0D44_06850	COG1181	Belongs to the D-alanine--D-alanine ligase family
M0D44_06855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M0D44_06860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M0D44_06870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M0D44_06875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M0D44_06890	COG3116	cell division
M0D44_06935	COG0792	nuclease activity
M0D44_06940	COG1988	membrane-bound metal-dependent
M0D44_06945	COG0277	FAD linked oxidase domain protein
M0D44_06960	COG0745	RESPONSE REGULATOR receiver
M0D44_06965	COG2205	protein histidine kinase activity
M0D44_06975	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M0D44_06980	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M0D44_07000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M0D44_07005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M0D44_07010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M0D44_07030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M0D44_07030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M0D44_07045	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M0D44_07060	COG0488	(ABC) transporter
M0D44_07065	COG0242	peptide deformylase activity
M0D44_07090	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M0D44_07135	COG2188	Transcriptional regulator
M0D44_07145	COG1450	Type ii and iii secretion system protein
M0D44_07160	COG3166	PFAM Fimbrial assembly family protein
M0D44_07165	COG3156	type II secretion system protein K
M0D44_07170	COG4795	General secretion pathway protein
M0D44_07175	COG2165	general secretion pathway protein
M0D44_07180	COG4970	Tfp pilus assembly protein FimT
M0D44_07185	COG2165	general secretion pathway protein
M0D44_07190	COG1459	type II secretion system
M0D44_07195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M0D44_07200	COG1404	Belongs to the peptidase S8 family
M0D44_07205	COG5295	Hep Hag repeat protein
M0D44_07220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M0D44_07225	COG4974	Belongs to the 'phage' integrase family
M0D44_07245	COG0795	lipopolysaccharide-transporting ATPase activity
M0D44_07255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M0D44_07270	COG0525	valine-tRNA ligase activity
M0D44_07300	COG0726	polysaccharide deacetylase
M0D44_07300	COG1649	PFAM Uncharacterised BCR, COG1649
M0D44_07305	COG1215	transferase activity, transferring glycosyl groups
M0D44_07320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M0D44_07325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M0D44_07330	COG1609	Transcriptional regulator
M0D44_07340	COG2188	Transcriptional regulator
M0D44_07355	COG3250	beta-galactosidase activity
M0D44_07385	COG4795	General secretion pathway protein
M0D44_07405	COG1459	type II secretion system
M0D44_07460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M0D44_07465	COG4191	Histidine kinase
M0D44_07470	COG0784	Response regulator, receiver
M0D44_07475	COG4251	negative regulation of phosphorylation
M0D44_07480	COG2823	Periplasmic or secreted lipoprotein
M0D44_07485	COG0673	inositol 2-dehydrogenase activity
M0D44_07490	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M0D44_07525	COG1051	belongs to the nudix hydrolase family
M0D44_07525	COG1056	cytidyltransferase-related domain
M0D44_07535	COG0583	DNA-binding transcription factor activity
M0D44_07550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M0D44_07555	COG0321	lipoyl(octanoyl) transferase activity
M0D44_07560	COG2921	Belongs to the UPF0250 family
M0D44_07570	COG1686	Belongs to the peptidase S11 family
M0D44_07575	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M0D44_07580	COG2951	lytic endotransglycosylase activity
M0D44_07585	COG5434	Belongs to the glycosyl hydrolase 28 family
M0D44_07595	COG0772	Belongs to the SEDS family
M0D44_07610	COG1792	Involved in formation and maintenance of cell shape
M0D44_07620	COG1077	Cell shape determining protein MreB Mrl
M0D44_07625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D44_07640	COG3284	Transcriptional regulator
M0D44_07685	COG0308	aminopeptidase N
M0D44_07690	COG3300	MHYT domain
M0D44_07690	COG5001	Diguanylate cyclase
M0D44_07695	COG2226	methyltransferase
M0D44_07710	COG2153	protein acetylation
M0D44_07720	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M0D44_07730	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M0D44_07740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M0D44_07750	COG2832	Protein of unknown function (DUF454)
M0D44_07760	COG0436	Aminotransferase
M0D44_07775	COG1505	serine-type exopeptidase activity
M0D44_07800	COG0181	hydroxymethylbilane synthase activity
M0D44_07810	COG3275	phosphorelay sensor kinase activity
M0D44_07820	COG2943	transferase activity, transferring hexosyl groups
M0D44_07835	COG0659	secondary active sulfate transmembrane transporter activity
M0D44_07840	COG5297	Belongs to the glycosyl hydrolase family 6
M0D44_07840	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D44_07845	COG0840	transmembrane signaling receptor activity
M0D44_07910	COG0598	Magnesium transport protein CorA
M0D44_07920	COG1113	amino acid transport
M0D44_07930	COG5297	Belongs to the glycosyl hydrolase family 6
M0D44_07935	COG4305	rare lipoprotein A
M0D44_07940	COG0697	spore germination
M0D44_08005	COG0435	Glutathione S-transferase
M0D44_08015	COG4221	oxidoreductase activity
M0D44_08060	COG0210	DNA helicase
M0D44_08165	COG1802	Transcriptional regulator
M0D44_08175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M0D44_08200	COG3052	prosthetic group binding
M0D44_08235	COG1595	DNA-templated transcription, initiation
M0D44_08240	COG2353	YceI-like domain
M0D44_08245	COG0778	Nitroreductase
M0D44_08270	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M0D44_08275	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M0D44_08285	COG3386	PFAM SMP-30 Gluconolaconase
M0D44_08300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M0D44_08315	COG3039	Transposase
M0D44_08350	COG0459	protein refolding
M0D44_08360	COG2356	endonuclease I
M0D44_08365	COG1324	tolerance protein
M0D44_08375	COG1505	serine-type exopeptidase activity
M0D44_08380	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M0D44_08385	COG0511	ligase activity, forming carbon-carbon bonds
M0D44_08395	COG0439	Biotin carboxylase
M0D44_08440	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M0D44_08455	COG0138	bifunctional purine biosynthesis protein purh
M0D44_08460	COG0151	Belongs to the GarS family
M0D44_08465	COG1289	transmembrane transporter activity
M0D44_08470	COG2814	Major facilitator Superfamily
M0D44_08480	COG2814	Major facilitator Superfamily
M0D44_08495	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M0D44_08510	COG0316	Belongs to the HesB IscA family
M0D44_08565	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M0D44_08575	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
M0D44_08590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M0D44_08600	COG0134	indole-3-glycerol-phosphate synthase activity
M0D44_08605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M0D44_08635	COG1597	lipid kinase activity
M0D44_08640	COG0456	acetyltransferase
M0D44_08645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M0D44_08655	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M0D44_08695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M0D44_08695	COG2111	Na H antiporter
M0D44_08700	COG1006	Multisubunit Na H antiporter MnhC subunit
M0D44_08705	COG0651	ATP synthesis coupled electron transport
M0D44_08715	COG2212	antiporter activity
M0D44_08720	COG1320	monovalent cation:proton antiporter activity
M0D44_08740	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M0D44_08760	COG3104	oligopeptide transport
M0D44_08775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M0D44_08800	COG0513	Belongs to the DEAD box helicase family
M0D44_08820	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_08835	COG0702	epimerase
M0D44_08860	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M0D44_08865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M0D44_08870	COG0297	glycogen (starch) synthase activity
M0D44_08880	COG1649	PFAM Uncharacterised BCR, COG1649
M0D44_08885	COG2354	Protein conserved in bacteria
M0D44_08890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D44_08895	COG1368	sulfuric ester hydrolase activity
M0D44_08900	COG1511	domain protein
M0D44_08900	COG3264	Mechanosensitive ion channel
M0D44_08975	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M0D44_09055	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M0D44_09065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M0D44_09070	COG0156	8-amino-7-oxononanoate synthase activity
M0D44_09085	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_09110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M0D44_09125	COG0445	tRNA wobble uridine modification
M0D44_09135	COG0657	acetylesterase activity
M0D44_09145	COG1414	Transcriptional regulator
M0D44_09160	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M0D44_09165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D44_09175	COG3485	protocatechuate 3,4-dioxygenase
M0D44_09180	COG3485	protocatechuate 3,4-dioxygenase
M0D44_09190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M0D44_09195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M0D44_09225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M0D44_09230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M0D44_09285	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M0D44_09295	COG0129	dihydroxy-acid dehydratase activity
M0D44_09340	COG1733	regulation of RNA biosynthetic process
M0D44_09345	COG0702	epimerase
M0D44_09375	COG0583	DNA-binding transcription factor activity
M0D44_09380	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M0D44_09435	COG1902	pentaerythritol trinitrate reductase activity
M0D44_09440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M0D44_09445	COG0596	Alpha beta hydrolase
M0D44_09460	COG2814	Major facilitator Superfamily
M0D44_09465	COG0583	DNA-binding transcription factor activity
M0D44_09470	COG0084	hydrolase, TatD family'
M0D44_09490	COG2252	PERMEase
M0D44_09535	COG0596	Alpha beta hydrolase
M0D44_09550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M0D44_09570	COG2072	flavoprotein involved in K transport
M0D44_09575	COG2351	hydroxyisourate hydrolase activity
M0D44_09580	COG4807	Protein conserved in bacteria
M0D44_09590	COG1643	Atp-dependent helicase
M0D44_09600	COG1187	pseudouridine synthase activity
M0D44_09615	COG2130	NADP-dependent
M0D44_09620	COG0656	L-ascorbic acid biosynthetic process
M0D44_09640	COG1764	response to oxidative stress
M0D44_09645	COG1846	Transcriptional regulator
M0D44_09650	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M0D44_09660	COG0697	spore germination
M0D44_09670	COG0523	cobalamin synthesis protein
M0D44_09725	COG1960	acyl-CoA dehydrogenase activity
M0D44_09730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M0D44_09735	COG4770	biotin carboxylase activity
M0D44_09765	COG2224	Isocitrate lyase
M0D44_09770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M0D44_09775	COG0583	DNA-binding transcription factor activity
M0D44_09780	COG0475	glutathione-regulated potassium exporter activity
M0D44_09810	COG0681	Belongs to the peptidase S26 family
M0D44_09815	COG0339	signal peptide processing
M0D44_09820	COG1446	asparaginase
M0D44_09840	COG0564	pseudouridine synthase activity
M0D44_09855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M0D44_09865	COG1181	Belongs to the D-alanine--D-alanine ligase family
M0D44_09875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D44_09880	COG0318	PFAM AMP-dependent synthetase and ligase
M0D44_09885	COG0727	PFAM Uncharacterised protein family (UPF0153)
M0D44_09890	COG0596	Alpha beta hydrolase
M0D44_09900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D44_09915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M0D44_09940	COG2205	protein histidine kinase activity
M0D44_09945	COG0028	Belongs to the TPP enzyme family
M0D44_09955	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M0D44_09960	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M0D44_09965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M0D44_10005	COG0183	Belongs to the thiolase family
M0D44_10020	COG2032	superoxide dismutase activity
M0D44_10025	COG2032	superoxide dismutase activity
M0D44_10030	COG2204	response regulator
M0D44_10035	COG3852	Histidine kinase
M0D44_10040	COG0004	ammonium transporteR
M0D44_10045	COG0347	Belongs to the P(II) protein family
M0D44_10050	COG0174	glutamine synthetase
M0D44_10055	COG1968	undecaprenyl-diphosphatase activity
M0D44_10095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D44_10105	COG2062	phosphohistidine phosphatase, SixA
M0D44_10110	COG0489	protein tyrosine kinase activity
M0D44_10130	COG3620	sequence-specific DNA binding
M0D44_10135	COG3550	peptidyl-serine autophosphorylation
M0D44_10140	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
M0D44_10145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M0D44_10160	COG0517	IMP dehydrogenase activity
M0D44_10160	COG1125	glycine betaine transport
M0D44_10175	COG1119	ATPase activity
M0D44_10185	COG1473	amidohydrolase
M0D44_10190	COG1752	Esterase of the alpha-beta hydrolase superfamily
M0D44_10200	COG1522	sequence-specific DNA binding
M0D44_10205	COG3186	Phenylalanine-4-hydroxylase
M0D44_10215	COG2755	lipolytic protein G-D-S-L family
M0D44_10225	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_10230	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M0D44_10235	COG1609	Transcriptional regulator
M0D44_10255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M0D44_10265	COG2755	lipolytic protein G-D-S-L family
M0D44_10265	COG0657	acetylesterase activity
M0D44_10275	COG2755	lipolytic protein G-D-S-L family
M0D44_10315	COG0366	Alpha amylase catalytic
M0D44_10320	COG0366	Alpha amylase catalytic
M0D44_10325	COG2831	hemolysin activation secretion protein
M0D44_10330	COG3210	domain, Protein
M0D44_10340	COG3210	domain, Protein
M0D44_10355	COG3210	domain, Protein
M0D44_10400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M0D44_10440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M0D44_10450	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M0D44_10455	COG3710	Transcriptional regulator
M0D44_10475	COG2197	response regulator
M0D44_10480	COG4585	Histidine kinase
M0D44_10485	COG1755	Isoprenylcysteine carboxyl methyltransferase
M0D44_10490	COG1304	FMN binding
M0D44_10515	COG1012	belongs to the aldehyde dehydrogenase family
M0D44_10520	COG4772	TonB-dependent receptor
M0D44_10530	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M0D44_10580	COG0714	Associated with various cellular activities
M0D44_10620	COG0477	Major facilitator Superfamily
M0D44_10625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M0D44_10685	COG3237	CsbD-like
M0D44_10695	COG0625	glutathione transferase activity
M0D44_10705	COG1272	protein, Hemolysin III
M0D44_10710	COG1111	helicase
M0D44_10710	COG1205	dead DEAH box helicase
M0D44_10790	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M0D44_10820	COG1132	(ABC) transporter
M0D44_10850	COG0367	asparagine synthase
M0D44_10870	COG0438	transferase activity, transferring glycosyl groups
M0D44_10870	COG0297	glycogen (starch) synthase activity
M0D44_10875	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M0D44_10895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M0D44_10915	COG3459	Glycosyltransferase 36 associated
M0D44_10955	COG0067	glutamate synthase
M0D44_10955	COG0069	glutamate synthase activity
M0D44_10955	COG0070	glutamate synthase
M0D44_10960	COG0493	'glutamate synthase
M0D44_10980	COG1064	alcohol dehydrogenase
M0D44_10985	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D44_10990	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D44_10995	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M0D44_11005	COG2234	aminopeptidase activity
M0D44_11015	COG4942	peptidase
M0D44_11020	COG0793	Belongs to the peptidase S41A family
M0D44_11025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M0D44_11065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D44_11075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M0D44_11110	COG0501	Belongs to the peptidase M48B family
M0D44_11120	COG0187	DNA topoisomerase II activity
M0D44_11135	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M0D44_11155	COG0726	polysaccharide deacetylase
M0D44_11160	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M0D44_11175	COG0584	glycerophosphoryl diester phosphodiesterase
M0D44_11185	COG0861	Integral membrane protein TerC family
M0D44_11190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M0D44_11205	COG2271	Major facilitator Superfamily
M0D44_11210	COG1929	Belongs to the glycerate kinase type-1 family
M0D44_11215	COG3835	regulator
M0D44_11220	COG3706	GGDEF domain
M0D44_11240	COG3537	Alpha-1,2-mannosidase
M0D44_11245	COG0531	amino acid
M0D44_11265	COG0583	DNA-binding transcription factor activity
M0D44_11270	COG0604	alcohol dehydrogenase
M0D44_11275	COG1322	Protein conserved in bacteria
M0D44_11285	COG0386	Belongs to the glutathione peroxidase family
M0D44_11295	COG2853	Lipoprotein
M0D44_11315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M0D44_11320	COG1127	ABC transporter
M0D44_11325	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M0D44_11330	COG1074	ATP-dependent DNA helicase activity
M0D44_11375	COG0564	pseudouridine synthase activity
M0D44_11420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D44_11455	COG0477	Major facilitator Superfamily
M0D44_11460	COG1289	transmembrane transporter activity
M0D44_11470	COG1566	PFAM secretion protein HlyD family protein
M0D44_11485	COG0302	gtp cyclohydrolase
M0D44_11505	COG0730	response to heat
M0D44_11510	COG3012	SEC-C Motif Domain Protein
M0D44_11520	COG0676	glucose-6-phosphate 1-epimerase activity
M0D44_11540	COG3135	benzoate transporter
M0D44_11570	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M0D44_11580	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M0D44_11590	COG1435	thymidine kinase activity
M0D44_11595	COG0210	DNA helicase
M0D44_11610	COG3132	Protein of unknown function, DUF480
M0D44_11615	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M0D44_11620	COG0284	orotidine-5'-phosphate decarboxylase activity
M0D44_11650	COG2937	Belongs to the GPAT DAPAT family
M0D44_11705	COG2211	Major facilitator Superfamily
M0D44_11730	COG3693	PFAM glycoside hydrolase, family 10
M0D44_11735	COG1904	glucuronate isomerase
M0D44_11770	COG3386	PFAM SMP-30 Gluconolaconase
M0D44_11800	COG0246	Mannitol dehydrogenase
M0D44_11805	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D44_11815	COG4948	Mandelate Racemase Muconate Lactonizing
M0D44_11825	COG3661	Belongs to the glycosyl hydrolase 67 family
M0D44_11845	COG2974	May be involved in recombination
M0D44_11860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M0D44_11870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M0D44_11875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M0D44_11880	COG0805	protein transport
M0D44_11890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M0D44_11890	COG0519	Catalyzes the synthesis of GMP from XMP
M0D44_11900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M0D44_11905	COG0752	glycyl-tRNA synthetase alpha subunit
M0D44_11915	COG0457	Tetratricopeptide repeat
M0D44_11920	COG4771	TonB-dependent receptor
M0D44_11925	COG0729	surface antigen
M0D44_11930	COG2911	Protein conserved in bacteria
M0D44_11950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D44_11955	COG3265	gluconokinase activity
M0D44_11960	COG2211	Major facilitator Superfamily
M0D44_11965	COG3459	Glycosyltransferase 36 associated
M0D44_11975	COG2205	protein histidine kinase activity
M0D44_11995	COG1414	Transcriptional regulator
M0D44_12000	COG0738	Major facilitator superfamily
M0D44_12005	COG3254	rhamnose metabolic process
M0D44_12010	COG4948	Mandelate Racemase Muconate Lactonizing
M0D44_12015	COG0179	Fumarylacetoacetate (FAA) hydrolase
M0D44_12020	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_12070	COG3162	membrane
M0D44_12075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M0D44_12080	COG1940	carbohydrate kinase activity
M0D44_12100	COG2091	lysine biosynthetic process via aminoadipic acid
M0D44_12110	COG3540	Alkaline phosphatase
M0D44_12115	COG0357	Ribosomal RNA small subunit methyltransferase G
M0D44_12135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D44_12160	COG2159	amidohydrolase
M0D44_12170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M0D44_12175	COG0583	DNA-binding transcription factor activity
M0D44_12180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D44_12195	COG0210	DNA helicase
M0D44_12320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M0D44_12330	COG0408	coproporphyrinogen oxidase activity
M0D44_12345	COG1506	peptidase
M0D44_12345	COG4946	Tricorn protease homolog
M0D44_12345	COG0823	Involved in the tonB-independent uptake of proteins
M0D44_12360	COG0644	oxidoreductase
M0D44_12365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M0D44_12405	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_12425	COG0463	Glycosyl transferase, family 2
M0D44_12435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M0D44_12440	COG3100	YcgL domain-containing protein
M0D44_12455	COG3387	PFAM Glycoside hydrolase 15-related
M0D44_12460	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M0D44_12490	COG2239	Acts as a magnesium transporter
M0D44_12500	COG1042	CoA-binding domain protein
M0D44_12500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M0D44_12500	COG0045	succinate-CoA ligase (ADP-forming) activity
M0D44_12510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M0D44_12515	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M0D44_12545	COG1607	acyl-coa hydrolase
M0D44_12560	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M0D44_12565	COG0842	Transport permease protein
M0D44_12570	COG1131	(ABC) transporter
M0D44_12575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M0D44_12595	COG1476	TRANSCRIPTIONal
M0D44_12605	COG4555	ABC transporter
M0D44_12640	COG0625	glutathione transferase activity
M0D44_12735	COG1199	ATP-dependent helicase activity
M0D44_12765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M0D44_12810	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M0D44_12825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M0D44_12865	COG3237	CsbD-like
M0D44_12870	COG0180	Tryptophanyl-tRNA synthetase
M0D44_12895	COG0697	spore germination
M0D44_12920	COG1136	(ABC) transporter
M0D44_12925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D44_12930	COG4585	Histidine kinase
M0D44_12935	COG2197	response regulator
M0D44_12950	COG0753	catalase activity
M0D44_12955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M0D44_12960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D44_12965	COG0628	permease
M0D44_12985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M0D44_12995	COG1090	epimerase
M0D44_13035	COG1690	Belongs to the RtcB family
M0D44_13065	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M0D44_13175	COG3291	Pkd domain containing protein
M0D44_13175	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M0D44_13195	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M0D44_13200	COG1166	arginine decarboxylase activity
M0D44_13210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M0D44_13220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M0D44_13220	COG2755	lipolytic protein G-D-S-L family
M0D44_13225	COG4221	oxidoreductase activity
M0D44_13240	COG0018	arginyl-trna synthetase
M0D44_13245	COG2003	Belongs to the UPF0758 family
M0D44_13250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M0D44_13275	COG0463	Glycosyl transferase, family 2
M0D44_13290	COG1475	DNA binding
M0D44_13295	COG1192	Involved in chromosome partitioning
M0D44_13310	COG0708	Exodeoxyribonuclease III
M0D44_13315	COG2211	Major facilitator Superfamily
M0D44_13330	COG0739	heme binding
M0D44_13375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M0D44_13390	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M0D44_13440	COG0358	DNA primase activity
M0D44_13445	COG1295	ribonuclease BN
M0D44_13455	COG1610	YqeY-like protein
M0D44_13465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M0D44_13470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M0D44_13480	COG2133	pyrroloquinoline quinone binding
M0D44_13485	COG4682	membrane
M0D44_13500	COG0531	amino acid
M0D44_13510	COG4948	Mandelate Racemase Muconate Lactonizing
M0D44_13520	COG3023	N-Acetylmuramoyl-L-alanine amidase
M0D44_13525	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
M0D44_13560	COG5383	Protein conserved in bacteria
M0D44_13585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D44_13590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D44_13595	COG1473	amidohydrolase
M0D44_13600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M0D44_13600	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M0D44_13605	COG1652	LysM domain
M0D44_13630	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
M0D44_13640	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M0D44_13645	COG3118	belongs to the thioredoxin family
M0D44_13655	COG2884	Cell division ATP-binding protein ftsE
M0D44_13660	COG2177	Part of the ABC transporter FtsEX involved in
M0D44_13665	COG2201	protein-glutamate methylesterase activity
M0D44_13670	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M0D44_13675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M0D44_13680	COG2860	membrane
M0D44_13685	COG1252	NADH dehydrogenase
M0D44_13700	COG0625	glutathione transferase activity
M0D44_13705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M0D44_13725	COG0534	Mate efflux family protein
M0D44_13730	COG0616	signal peptide processing
M0D44_13740	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_13755	COG0009	L-threonylcarbamoyladenylate synthase
M0D44_13760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M0D44_13760	COG1754	DNA topoisomerase type I activity
M0D44_13780	COG0758	DNA mediated transformation
M0D44_13785	COG1652	LysM domain
M0D44_13790	COG0242	peptide deformylase activity
M0D44_13795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M0D44_13800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M0D44_13800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M0D44_13845	COG1560	Kdo2-lipid A biosynthetic process
M0D44_13850	COG1490	D-aminoacyl-tRNA deacylase activity
M0D44_13855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M0D44_13950	COG1999	signal sequence binding
M0D44_13965	COG0024	Methionine aminopeptidase
M0D44_13975	COG0038	chloride channel
M0D44_14010	COG0251	oxidation-reduction process
M0D44_14025	COG1131	(ABC) transporter
M0D44_14085	COG1063	alcohol dehydrogenase
M0D44_14095	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_14110	COG1294	oxidase, subunit
M0D44_14115	COG1271	oxidase subunit
M0D44_14130	COG3546	catalase activity
M0D44_14135	COG3685	Protein conserved in bacteria
M0D44_14150	COG2972	Histidine kinase
M0D44_14165	COG0531	amino acid
M0D44_14180	COG3590	peptidase
M0D44_14190	COG0667	Aldo Keto reductase
M0D44_14200	COG0583	DNA-binding transcription factor activity
M0D44_14210	COG3384	dioxygenase
M0D44_14220	COG1573	uracil-dna glycosylase
M0D44_14225	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M0D44_14235	COG0025	NhaP-type Na H and K H
M0D44_14240	COG1131	(ABC) transporter
M0D44_14245	COG0842	Transport permease protein
M0D44_14280	COG1404	Belongs to the peptidase S8 family
M0D44_14295	COG0745	RESPONSE REGULATOR receiver
M0D44_14340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D44_14345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M0D44_14365	COG2202	Pas domain
M0D44_14365	COG2205	protein histidine kinase activity
M0D44_14385	COG2813	Specifically methylates the guanine in position
M0D44_14390	COG1187	pseudouridine synthase activity
M0D44_14395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D44_14415	COG2205	protein histidine kinase activity
M0D44_14415	COG3437	response regulator, receiver
M0D44_14415	COG3850	Histidine kinase
M0D44_14415	COG4999	Histidine kinase
M0D44_14430	COG0697	spore germination
M0D44_14435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M0D44_14440	COG2011	ABC-type metal ion transport system permease component
M0D44_14480	COG0508	dehydrogenase complex catalyzes the overall conversion of
M0D44_14490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M0D44_14515	COG0356	it plays a direct role in the translocation of protons across the membrane
M0D44_14525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M0D44_14530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M0D44_14535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M0D44_14540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M0D44_14565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M0D44_14585	COG0577	efflux transmembrane transporter activity
M0D44_14585	COG1136	(ABC) transporter
M0D44_14590	COG0577	efflux transmembrane transporter activity
M0D44_14590	COG1136	(ABC) transporter
M0D44_14595	COG1136	(ABC) transporter
M0D44_14595	COG0577	efflux transmembrane transporter activity
M0D44_14600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D44_14605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M0D44_14655	COG0339	signal peptide processing
M0D44_14670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M0D44_14680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M0D44_14695	COG1956	GAF domain-containing protein
M0D44_14700	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M0D44_14710	COG0720	synthase
M0D44_14715	COG0513	Belongs to the DEAD box helicase family
M0D44_14725	COG0625	glutathione transferase activity
M0D44_14755	COG0626	cystathionine gamma-synthase activity
M0D44_14770	COG0110	maltose O-acetyltransferase activity
M0D44_14775	COG1216	Glycosyl transferase, family 2
M0D44_14775	COG0438	transferase activity, transferring glycosyl groups
M0D44_14780	COG3754	Rhamnan synthesis protein F
M0D44_14790	COG2226	methyltransferase
M0D44_14810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D44_14820	COG0300	oxidoreductase activity
M0D44_14825	COG0277	FAD linked oxidase domain protein
M0D44_14830	COG0546	phosphoglycolate phosphatase activity
M0D44_14830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M0D44_14845	COG2086	electron transfer activity
M0D44_14870	COG0662	Cupin 2, conserved barrel domain protein
M0D44_14870	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M0D44_14875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M0D44_14910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M0D44_14910	COG3218	ABC-type transport auxiliary lipoprotein component
M0D44_14915	COG1127	ABC transporter
M0D44_14920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M0D44_14935	COG0442	prolyl-tRNA aminoacylation
M0D44_14945	COG1183	phosphatidylcholine synthase activity
M0D44_14965	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M0D44_14970	COG1012	belongs to the aldehyde dehydrogenase family
M0D44_14975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M0D44_14985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M0D44_15000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M0D44_15010	COG2205	protein histidine kinase activity
M0D44_15035	COG3791	Glutathione-dependent formaldehyde-activating
M0D44_15060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M0D44_15065	COG0697	spore germination
M0D44_15075	COG1307	EDD domain protein, DegV family
M0D44_15110	COG0402	S-adenosylhomocysteine deaminase activity
M0D44_15115	COG3964	amidohydrolase
M0D44_15130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M0D44_15150	COG0436	Aminotransferase
M0D44_15155	COG1162	GTPase activity
M0D44_15185	COG2211	Major facilitator Superfamily
M0D44_15190	COG1609	Transcriptional regulator
M0D44_15195	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_15200	COG2851	Citrate transporter
M0D44_15215	COG0642	Histidine kinase
M0D44_15225	COG2197	response regulator
M0D44_15245	COG0667	Aldo Keto reductase
M0D44_15250	COG0583	DNA-binding transcription factor activity
M0D44_15265	COG4191	Histidine kinase
M0D44_15280	COG1301	dicarboxylic acid transport
M0D44_15285	COG0281	malic enzyme
M0D44_15285	COG0280	phosphate acetyltransferase
M0D44_15455	COG1560	Kdo2-lipid A biosynthetic process
M0D44_15460	COG1519	Transferase
M0D44_15465	COG1538	Outer membrane efflux protein
M0D44_15470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M0D44_15490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M0D44_15495	COG0066	3-isopropylmalate dehydratase activity
M0D44_15505	COG0473	3-isopropylmalate dehydrogenase activity
M0D44_15510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M0D44_15530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M0D44_15535	COG0405	Gamma-glutamyltransferase
M0D44_15540	COG0840	transmembrane signaling receptor activity
M0D44_15545	COG4946	Tricorn protease homolog
M0D44_15545	COG1506	peptidase
M0D44_15545	COG0823	Involved in the tonB-independent uptake of proteins
M0D44_15550	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M0D44_15555	COG3710	Transcriptional regulator
M0D44_15575	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M0D44_15585	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
M0D44_15645	COG0563	adenylate kinase activity
M0D44_15650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M0D44_15660	COG3781	membrane
M0D44_15665	COG0671	phosphoesterase, PA-phosphatase related
M0D44_15675	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_15690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M0D44_15720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M0D44_15725	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M0D44_15740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M0D44_15755	COG0352	thiamine-phosphate diphosphorylase activity
M0D44_15760	COG1773	rubredoxin
M0D44_15765	COG2912	Transglutaminase-like superfamily
M0D44_15785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M0D44_15810	COG0006	proline dipeptidase activity
M0D44_15820	COG0006	proline dipeptidase activity
M0D44_15835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M0D44_15840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M0D44_15850	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M0D44_15855	COG1561	YicC-like family, N-terminal region
M0D44_15875	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_15890	COG1175	transmembrane transport
M0D44_15895	COG3659	wide pore channel activity
M0D44_15905	COG2390	Transcriptional regulator
M0D44_15910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M0D44_15915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M0D44_15920	COG0583	DNA-binding transcription factor activity
M0D44_15935	COG2271	Major facilitator Superfamily
M0D44_15950	COG2721	sulfolactate sulfo-lyase activity
M0D44_15960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M0D44_15990	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M0D44_16040	COG2304	oxidoreductase activity
M0D44_16050	COG1301	dicarboxylic acid transport
M0D44_16060	COG4773	Receptor
M0D44_16065	COG0583	DNA-binding transcription factor activity
M0D44_16070	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_16075	COG0739	heme binding
M0D44_16080	COG1376	ErfK ybiS ycfS ynhG family protein
M0D44_16105	COG1022	Amp-dependent synthetase and ligase
M0D44_16115	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_16130	COG0642	Histidine kinase
M0D44_16150	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M0D44_16155	COG4149	molybdate abc transporter
M0D44_16160	COG0725	ABC transporter, periplasmic molybdate-binding protein
M0D44_16165	COG3453	Protein conserved in bacteria
M0D44_16165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M0D44_16175	COG3047	cAMP biosynthetic process
M0D44_16190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M0D44_16230	COG0469	pyruvate kinase activity
M0D44_16235	COG3588	fructose-bisphosphate aldolase
M0D44_16240	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M0D44_16270	COG0784	Response regulator, receiver
M0D44_16270	COG2198	Histidine kinase
M0D44_16270	COG2205	protein histidine kinase activity
M0D44_16290	COG0175	sulfate reduction
M0D44_16295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M0D44_16300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M0D44_16310	COG2895	sulfate adenylyltransferase (ATP) activity
M0D44_16310	COG0529	Catalyzes the synthesis of activated sulfate
M0D44_16320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D44_16335	COG0308	aminopeptidase N
M0D44_16345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M0D44_16355	COG4948	Mandelate Racemase Muconate Lactonizing
M0D44_16360	COG3250	beta-galactosidase activity
M0D44_16380	COG1609	Transcriptional regulator
M0D44_16390	COG1970	mechanosensitive ion channel activity
M0D44_16410	COG3273	potassium ion transport
M0D44_16410	COG0471	metal ion transport
M0D44_16420	COG2022	thiamine diphosphate biosynthetic process
M0D44_16480	COG1074	ATP-dependent DNA helicase activity
M0D44_16500	COG2003	Belongs to the UPF0758 family
M0D44_16590	COG0745	RESPONSE REGULATOR receiver
M0D44_16610	COG3209	COG3209 Rhs family protein
M0D44_16620	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M0D44_16660	COG0045	succinate-CoA ligase (ADP-forming) activity
M0D44_16675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M0D44_16675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M0D44_16685	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M0D44_16690	COG0564	pseudouridine synthase activity
M0D44_16705	COG3011	Protein conserved in bacteria
M0D44_16710	COG0840	transmembrane signaling receptor activity
M0D44_16725	COG3387	PFAM Glycoside hydrolase 15-related
M0D44_16730	COG1877	trehalose-phosphatase activity
M0D44_16780	COG0542	response to heat
M0D44_16790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D44_16815	COG4206	TonB-dependent receptor
M0D44_16840	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M0D44_16850	COG1492	cobalamin metabolic process
M0D44_16860	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M0D44_16890	COG0019	diaminopimelate decarboxylase activity
M0D44_16905	COG4264	IucA IucC family
M0D44_16915	COG4772	TonB-dependent receptor
M0D44_16940	COG4651	solute:proton antiporter activity
M0D44_16940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M0D44_16970	COG0488	(ABC) transporter
M0D44_17010	COG0477	Major facilitator Superfamily
M0D44_17025	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M0D44_17045	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M0D44_17055	COG3158	transport of potassium into the cell
M0D44_17065	COG2255	four-way junction helicase activity
M0D44_17070	COG0824	Thioesterase
M0D44_17090	COG0823	Involved in the tonB-independent uptake of proteins
M0D44_17095	COG2885	chlorophyll binding
M0D44_17105	COG0602	queuosine metabolic process
M0D44_17115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M0D44_17145	COG0840	transmembrane signaling receptor activity
M0D44_17155	COG1187	pseudouridine synthase activity
M0D44_17175	COG0514	ATP-dependent DNA helicase (RecQ)
M0D44_17180	COG0783	Belongs to the Dps family
M0D44_17185	COG1643	Atp-dependent helicase
M0D44_17225	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
M0D44_17240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M0D44_17250	COG1215	transferase activity, transferring glycosyl groups
M0D44_17255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M0D44_17265	COG1199	ATP-dependent helicase activity
M0D44_17275	COG1397	ADP-ribosylglycohydrolase
M0D44_17285	COG0189	ligase activity
M0D44_17300	COG0835	chemotaxis
M0D44_17305	COG0840	transmembrane signaling receptor activity
M0D44_17310	COG0784	Response regulator, receiver
M0D44_17310	COG0643	Histidine kinase
M0D44_17310	COG2198	Histidine kinase
M0D44_17335	COG1595	DNA-templated transcription, initiation
M0D44_17340	COG2304	oxidoreductase activity
M0D44_17345	COG1446	asparaginase
M0D44_17350	COG3142	Participates in the control of copper homeostasis
M0D44_17385	COG3537	Alpha-1,2-mannosidase
M0D44_17395	COG1486	melibiose metabolic process
M0D44_17405	COG0531	amino acid
M0D44_17420	COG1472	Belongs to the glycosyl hydrolase 3 family
M0D44_17430	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M0D44_17440	COG1388	LysM domain
M0D44_17440	COG3858	chitin binding
M0D44_17455	COG0837	glucose binding
M0D44_17460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M0D44_17470	COG0494	nUDIX hydrolase
M0D44_17480	COG3956	TIGRFAM MazG family protein
M0D44_17485	COG1742	UPF0060 membrane protein
M0D44_17490	COG0330	HflC and HflK could
M0D44_17500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M0D44_17505	COG0509	glycine decarboxylation via glycine cleavage system
M0D44_17530	COG1960	acyl-CoA dehydrogenase activity
M0D44_17540	COG1309	transcriptional regulator
M0D44_17545	COG4771	TonB-dependent receptor
M0D44_17555	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M0D44_17560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M0D44_17565	COG0463	Glycosyl transferase, family 2
M0D44_17570	COG0516	GMP reductase activity
M0D44_17570	COG0517	IMP dehydrogenase activity
M0D44_17575	COG2982	Protein involved in outer membrane biogenesis
M0D44_17580	COG1272	protein, Hemolysin III
M0D44_17585	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M0D44_17590	COG0739	heme binding
M0D44_17595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D44_17600	COG0626	cystathionine gamma-synthase activity
M0D44_17605	COG0460	homoserine dehydrogenase
M0D44_17605	COG0527	aspartate kinase activity
M0D44_17615	COG1760	l-serine dehydratase
M0D44_17635	COG2353	YceI-like domain
M0D44_17645	COG0784	Response regulator, receiver
M0D44_17645	COG5002	protein histidine kinase activity
M0D44_17650	COG0784	Response regulator, receiver
M0D44_17650	COG2205	protein histidine kinase activity
M0D44_17660	COG0477	Major facilitator Superfamily
M0D44_17665	COG2204	response regulator
M0D44_17735	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M0D44_17750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M0D44_17765	COG1842	Phage shock protein A
M0D44_17790	COG0754	glutathionylspermidine amidase activity
M0D44_17795	COG2814	Major facilitator Superfamily
M0D44_17855	COG0531	amino acid
M0D44_17875	COG1113	amino acid transport
M0D44_17885	COG1271	oxidase subunit
M0D44_17890	COG1294	oxidase, subunit
M0D44_17900	COG2239	Acts as a magnesium transporter
M0D44_17905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M0D44_17910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D44_17920	COG1660	Displays ATPase and GTPase activities
M0D44_17930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D44_17945	COG1137	ATPase activity
M0D44_17960	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M0D44_17970	COG0271	Belongs to the BolA IbaG family
M0D44_17975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M0D44_17995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M0D44_18005	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M0D44_18015	COG0628	permease
M0D44_18030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M0D44_18035	COG3178	'Phosphotransferase
M0D44_18045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D44_18050	COG1555	photosystem II stabilization
M0D44_18065	COG1477	protein flavinylation
M0D44_18090	COG3128	pkhd-type hydroxylase
M0D44_18095	COG4774	siderophore transport
M0D44_18100	COG2146	nitrite reductase [NAD(P)H] activity
M0D44_18110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M0D44_18115	COG0719	Fe-S assembly protein
M0D44_18120	COG0396	ATPase activity
M0D44_18125	COG0719	Fe-S assembly protein
M0D44_18130	COG1959	2 iron, 2 sulfur cluster binding
M0D44_18140	COG0693	protein deglycase activity
M0D44_18160	COG4942	peptidase
M0D44_18180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M0D44_18205	COG0519	Catalyzes the synthesis of GMP from XMP
M0D44_18210	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M0D44_18215	COG1678	Uncharacterized ACR, COG1678
M0D44_18220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M0D44_18225	COG0540	Belongs to the ATCase OTCase family
M0D44_18230	COG1764	response to oxidative stress
M0D44_18240	COG0384	phenazine biosynthesis protein PhzF
M0D44_18250	COG0527	aspartate kinase activity
M0D44_18275	COG0142	geranyltranstransferase activity
M0D44_18280	COG0629	single-stranded DNA binding
M0D44_18325	COG0673	inositol 2-dehydrogenase activity
M0D44_18330	COG2211	Major facilitator Superfamily
M0D44_18340	COG1609	Transcriptional regulator
M0D44_18345	COG5001	Diguanylate cyclase
M0D44_18345	COG4251	negative regulation of phosphorylation
M0D44_18345	COG3706	GGDEF domain
M0D44_18345	COG2203	Gaf domain
M0D44_18355	COG2080	2 iron, 2 sulfur cluster binding
M0D44_18360	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M0D44_18365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M0D44_18370	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M0D44_18405	COG2879	small protein
M0D44_18410	COG1966	Carbon starvation protein
M0D44_18415	COG1741	Belongs to the pirin family
M0D44_18430	COG1741	Belongs to the pirin family
M0D44_18435	COG1515	deoxyribonuclease V activity
M0D44_18440	COG0588	phosphoglycerate mutase activity
M0D44_18450	COG3590	peptidase
M0D44_18455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M0D44_18465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M0D44_18470	COG2199	diguanylate cyclase activity
M0D44_18470	COG2200	EAL domain
M0D44_18470	COG2202	Pas domain
M0D44_18475	COG0835	chemotaxis
M0D44_18480	COG0840	transmembrane signaling receptor activity
M0D44_18485	COG2198	Histidine kinase
M0D44_18485	COG0643	Histidine kinase
M0D44_18495	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M0D44_18505	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M0D44_18510	COG0745	RESPONSE REGULATOR receiver
M0D44_18520	COG2205	protein histidine kinase activity
M0D44_18530	COG4452	Inner membrane protein CreD
M0D44_18555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D44_18560	COG0735	belongs to the Fur family
M0D44_18575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D44_18585	COG1309	transcriptional regulator
M0D44_18595	COG2207	Transcriptional regulator
M0D44_18610	COG0583	DNA-binding transcription factor activity
M0D44_18615	COG2814	Major facilitator Superfamily
M0D44_18620	COG0667	Aldo Keto reductase
M0D44_18720	COG5002	protein histidine kinase activity
M0D44_18720	COG5001	Diguanylate cyclase
M0D44_18725	COG1187	pseudouridine synthase activity
M0D44_18750	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M0D44_18760	COG0475	glutathione-regulated potassium exporter activity
M0D44_18765	COG5002	protein histidine kinase activity
M0D44_18765	COG5000	phosphorelay sensor kinase activity
M0D44_18770	COG0745	RESPONSE REGULATOR receiver
M0D44_18780	COG3713	MltA-interacting MipA family protein
M0D44_18800	COG1132	(ABC) transporter
M0D44_18880	COG3118	belongs to the thioredoxin family
M0D44_18890	COG0495	leucyl-tRNA aminoacylation
M0D44_18905	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M0D44_18920	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M0D44_18940	COG2968	Membrane
M0D44_18955	COG3164	Protein of unknown function
M0D44_18965	COG0312	modulator of DNA gyrase
M0D44_18970	COG3028	Belongs to the UPF0307 family
M0D44_18975	COG0312	modulator of DNA gyrase
M0D44_18985	COG4104	PAAR repeat-containing protein
M0D44_18990	COG0142	geranyltranstransferase activity
M0D44_18995	COG1722	exodeoxyribonuclease VII activity
M0D44_19000	COG0037	tRNA processing
M0D44_19005	COG1785	Belongs to the alkaline phosphatase family
M0D44_19010	COG1301	dicarboxylic acid transport
M0D44_19015	COG2226	methyltransferase
M0D44_19030	COG0791	NLP P60 protein
M0D44_19035	COG0791	NLP P60 protein
M0D44_19040	COG1047	Peptidyl-prolyl cis-trans
M0D44_19045	COG2311	Membrane
M0D44_19050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D44_19055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M0D44_19075	COG3590	peptidase
M0D44_19080	COG3590	peptidase
M0D44_19100	COG0489	protein tyrosine kinase activity
M0D44_19105	COG0717	Belongs to the dCTP deaminase family
M0D44_19135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M0D44_19140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M0D44_19155	COG0494	nUDIX hydrolase
M0D44_19165	COG0433	COG0433 Predicted ATPase
M0D44_19175	COG0688	phosphatidylethanolamine metabolic process
M0D44_19185	COG2890	protein-(glutamine-N5) methyltransferase activity
M0D44_19190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M0D44_19195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M0D44_19200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M0D44_19220	COG0101	tRNA pseudouridine synthase activity
M0D44_19225	COG0135	phosphoribosylanthranilate isomerase activity
M0D44_19240	COG0133	tryptophan synthase activity
M0D44_19255	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M0D44_19260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M0D44_19295	COG0149	triose-phosphate isomerase activity
M0D44_19310	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M0D44_19320	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M0D44_19325	COG0649	NAD binding
M0D44_19330	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M0D44_19340	COG1034	ATP synthesis coupled electron transport
M0D44_19345	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M0D44_19355	COG0839	Belongs to the complex I subunit 6 family
M0D44_19375	COG1007	ATP synthesis coupled electron transport
M0D44_19385	COG0779	Required for maturation of 30S ribosomal subunits
M0D44_19390	COG0195	Participates in both transcription termination and antitermination
M0D44_19400	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M0D44_19410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M0D44_19415	COG1185	polyribonucleotide nucleotidyltransferase activity
M0D44_19450	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M0D44_19460	COG2095	MarC family integral membrane protein
M0D44_19470	COG1611	Belongs to the LOG family
M0D44_19515	COG0556	nucleotide-excision repair
M0D44_19530	COG3505	Type IV secretory pathway VirD4
M0D44_19550	COG2948	multi-organism process
M0D44_19570	COG3702	type iv secretory pathway
M0D44_19580	COG0366	Alpha amylase catalytic
M0D44_19615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M0D44_19620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M0D44_19635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M0D44_19640	COG0072	phenylalanine-tRNA ligase activity
M0D44_19640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M0D44_19695	COG0438	transferase activity, transferring glycosyl groups
M0D44_19700	COG0438	transferase activity, transferring glycosyl groups
M0D44_19710	COG0438	transferase activity, transferring glycosyl groups
M0D44_19735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M0D44_19745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M0D44_19765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M0D44_19775	COG1960	acyl-CoA dehydrogenase activity
M0D44_19785	COG3040	lipid binding
M0D44_19875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M0D44_20065	COG2944	sequence-specific DNA binding
M0D44_20105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M0D44_20115	COG0784	Response regulator, receiver
M0D44_20115	COG4191	Histidine kinase
M0D44_20125	COG1194	a g-specific adenine glycosylase
M0D44_20130	COG0552	protein localization to endoplasmic reticulum
M0D44_20140	COG3938	Belongs to the proline racemase family
M0D44_20145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D44_20160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M0D44_20170	COG0006	proline dipeptidase activity
M0D44_20185	COG0531	amino acid
M0D44_20230	COG1506	peptidase
M0D44_20230	COG0823	Involved in the tonB-independent uptake of proteins
M0D44_20250	COG0326	Molecular chaperone. Has ATPase activity
M0D44_20255	COG0742	ribosomal rna small subunit methyltransferase
M0D44_20260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M0D44_20270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M0D44_20275	COG0405	Gamma-glutamyltransferase
M0D44_20285	COG3291	Pkd domain containing protein
M0D44_20290	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M0D44_20315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M0D44_20325	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M0D44_20330	COG0343	queuine tRNA-ribosyltransferase activity
M0D44_20335	COG1862	Preprotein translocase
M0D44_20345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M0D44_20390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M0D44_20390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M0D44_20395	COG1105	Belongs to the carbohydrate kinase PfkB family
M0D44_20400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M0D44_20400	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M0D44_20405	COG1609	Transcriptional regulator
M0D44_20410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D44_20415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D44_20425	COG2902	Dehydrogenase
M0D44_20475	COG0477	Major facilitator Superfamily
M0D44_20485	COG5002	protein histidine kinase activity
M0D44_20485	COG2205	protein histidine kinase activity
M0D44_20485	COG0784	Response regulator, receiver
M0D44_20490	COG2733	membrane
M0D44_20500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M0D44_20510	COG2223	nitrite transmembrane transporter activity
M0D44_20515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M0D44_20520	COG0243	molybdopterin cofactor binding
M0D44_20530	COG0477	Major facilitator Superfamily
M0D44_20540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D44_20545	COG0174	glutamine synthetase
M0D44_20550	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M0D44_20565	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M0D44_20585	COG3842	ATPase activity
M0D44_20590	COG1176	ABC-type spermidine putrescine transport system, permease component I
M0D44_20595	COG1177	transmembrane transport
M0D44_20605	COG1012	belongs to the aldehyde dehydrogenase family
M0D44_20620	COG4535	Mg2 and Co2 transporter CorC
M0D44_20630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M0D44_20640	COG1702	phosphate starvation-inducible protein PhoH
M0D44_20660	COG0741	lytic transglycosylase activity
M0D44_20665	COG0723	plastoquinol--plastocyanin reductase activity
M0D44_20670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M0D44_20675	COG2857	Cytochrome c1
M0D44_20680	COG0625	glutathione transferase activity
M0D44_20685	COG2969	positive regulation of protein catabolic process
M0D44_20710	COG1201	RNA secondary structure unwinding
M0D44_20720	COG0835	chemotaxis
M0D44_20765	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M0D44_20775	COG1570	exodeoxyribonuclease VII activity
M0D44_20785	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M0D44_20785	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M0D44_20790	COG0802	atpase or kinase
M0D44_20795	COG0860	N-Acetylmuramoyl-L-alanine amidase
M0D44_20800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M0D44_20820	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_20825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M0D44_20830	COG0501	Belongs to the peptidase M48B family
M0D44_20840	COG2081	HI0933 family
M0D44_20845	COG4681	YaeQ
M0D44_20850	COG1671	Belongs to the UPF0178 family
M0D44_20860	COG0625	glutathione transferase activity
M0D44_20870	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M0D44_20875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M0D44_20880	COG0513	Belongs to the DEAD box helicase family
M0D44_20885	COG0488	(ABC) transporter
M0D44_20900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M0D44_20905	COG0483	inositol monophosphate 1-phosphatase activity
M0D44_20920	COG5001	Diguanylate cyclase
M0D44_20920	COG3300	MHYT domain
M0D44_20925	COG1509	lysine 2,3-aminomutase activity
M0D44_20940	COG0402	S-adenosylhomocysteine deaminase activity
M0D44_20945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M0D44_20965	COG4677	pectinesterase activity
M0D44_20985	COG4302	ethanolamine ammonia-lyase activity
M0D44_21005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M0D44_21035	COG2166	iron-sulfur cluster assembly
M0D44_21040	COG0215	cysteine-tRNA ligase activity
M0D44_21050	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M0D44_21055	COG0137	argininosuccinate synthase activity
M0D44_21060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M0D44_21065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M0D44_21080	COG0165	Argininosuccinate lyase
M0D44_21145	COG1294	oxidase, subunit
M0D44_21155	COG4988	ABC transporter
M0D44_21160	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M0D44_21170	COG1278	Cold shock
M0D44_21175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M0D44_21200	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M0D44_21220	COG4133	protoheme IX ABC transporter activity
M0D44_21225	COG0436	Aminotransferase
M0D44_21245	COG1187	pseudouridine synthase activity
M0D44_21250	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M0D44_21255	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M0D44_21260	COG2350	Protein conserved in bacteria
M0D44_21290	COG1175	transmembrane transport
M0D44_21295	COG0395	ABC-type sugar transport system, permease component
M0D44_21320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M0D44_21325	COG2957	Belongs to the agmatine deiminase family
M0D44_21340	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M0D44_21345	COG0539	negative regulation of cytoplasmic translation
M0D44_21350	COG0776	regulation of translation
M0D44_21360	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M0D44_21365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M0D44_21375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M0D44_21380	COG0475	glutathione-regulated potassium exporter activity
M0D44_21380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M0D44_21390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M0D44_21410	COG3002	Belongs to the UPF0753 family
M0D44_21415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M0D44_21420	COG0583	DNA-binding transcription factor activity
M0D44_21425	COG0583	DNA-binding transcription factor activity
M0D44_21430	COG0583	DNA-binding transcription factor activity
M0D44_21450	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_21470	COG2197	response regulator
M0D44_21485	COG1335	isochorismatase
M0D44_21500	COG2814	Major facilitator Superfamily
M0D44_21515	COG1914	H( )-stimulated, divalent metal cation uptake system
M0D44_21525	COG0590	tRNA wobble adenosine to inosine editing
M0D44_21535	COG0668	transmembrane transport
M0D44_21545	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M0D44_21560	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_21565	COG1183	phosphatidylcholine synthase activity
M0D44_21575	COG3243	poly(R)-hydroxyalkanoic acid synthase
M0D44_21590	COG0723	plastoquinol--plastocyanin reductase activity
M0D44_21590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M0D44_21600	COG2183	response to ionizing radiation
M0D44_21605	COG0784	Response regulator, receiver
M0D44_21605	COG5002	protein histidine kinase activity
M0D44_21605	COG2205	protein histidine kinase activity
M0D44_21670	COG0800	Aldolase
M0D44_21675	COG0129	dihydroxy-acid dehydratase activity
M0D44_21680	COG0363	glucosamine-6-phosphate deaminase activity
M0D44_21685	COG0837	glucose binding
M0D44_21690	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M0D44_21715	COG2009	succinate dehydrogenase
M0D44_21720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M0D44_21735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M0D44_21740	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M0D44_21750	COG4591	ABC-type transport system involved in lipoprotein release permease component
M0D44_21770	COG0811	peptide transport
M0D44_21780	COG1132	(ABC) transporter
M0D44_21785	COG1663	tetraacyldisaccharide 4'-kinase activity
M0D44_21790	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M0D44_21795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M0D44_21805	COG0322	excinuclease ABC activity
M0D44_21820	COG0582	viral genome integration into host DNA
M0D44_21830	COG1396	sequence-specific DNA binding
M0D44_21835	COG0583	DNA-binding transcription factor activity
M0D44_21850	COG4916	TIR domain
M0D44_21970	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_21980	COG4221	oxidoreductase activity
M0D44_21990	COG0560	Phosphoserine phosphatase
M0D44_21990	COG3830	Belongs to the UPF0237 family
M0D44_22025	COG2814	Major facilitator Superfamily
M0D44_22035	COG2816	NAD+ diphosphatase activity
M0D44_22050	COG1960	acyl-CoA dehydrogenase activity
M0D44_22070	COG0477	Major facilitator Superfamily
M0D44_22075	COG0583	DNA-binding transcription factor activity
M0D44_22265	COG0270	DNA (cytosine-5-)-methyltransferase activity
M0D44_22270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M0D44_22275	COG0629	single-stranded DNA binding
M0D44_22340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M0D44_22430	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M0D44_22450	COG1054	Belongs to the UPF0176 family
M0D44_22460	COG1530	ribonuclease E activity
M0D44_22465	COG0564	pseudouridine synthase activity
M0D44_22470	COG3064	Membrane
M0D44_22475	COG0428	transporter
M0D44_22485	COG2154	pterin-4-alpha-carbinolamine dehydratase
M0D44_22590	COG0631	protein serine/threonine phosphatase activity
M0D44_22595	COG0515	serine threonine protein kinase
M0D44_22620	COG1858	cytochrome C peroxidase
M0D44_22645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M0D44_22650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M0D44_22675	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M0D44_22680	COG1028	Short-chain dehydrogenase reductase Sdr
M0D44_22690	COG0653	protein targeting
M0D44_22705	COG0653	protein targeting
M0D44_22720	COG0653	protein targeting
M0D44_22740	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D44_22745	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D44_22750	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M0D44_22765	COG1024	Enoyl-CoA hydratase
M0D44_22775	COG1024	Enoyl-CoA hydratase
M0D44_22780	COG1024	Enoyl-CoA hydratase
M0D44_22785	COG3424	synthase