locus-tag	class	description
XSP_000001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XSP_000004	COG0187	DNA topoisomerase II activity
XSP_000006	COG0501	Belongs to the peptidase M48B family
XSP_000013	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XSP_000015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XSP_000021	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XSP_000022	COG0793	Belongs to the peptidase S41A family
XSP_000023	COG4942	peptidase
XSP_000025	COG2234	aminopeptidase activity
XSP_000027	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XSP_000028	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XSP_000029	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XSP_000030	COG1064	alcohol dehydrogenase
XSP_000032	COG0493	'glutamate synthase
XSP_000033	COG0069	glutamate synthase activity
XSP_000033	COG0070	glutamate synthase
XSP_000033	COG0067	glutamate synthase
XSP_000036	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XSP_000040	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XSP_000043	COG3459	Glycosyltransferase 36 associated
XSP_000046	COG1111	helicase
XSP_000046	COG1205	dead DEAH box helicase
XSP_000047	COG1272	protein, Hemolysin III
XSP_000054	COG3590	peptidase
XSP_000056	COG0583	DNA-binding transcription factor activity
XSP_000057	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_000071	COG1733	regulation of RNA biosynthetic process
XSP_000072	COG3237	CsbD-like
XSP_000081	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XSP_000092	COG0714	Associated with various cellular activities
XSP_000097	COG0596	Alpha beta hydrolase
XSP_000105	COG4772	TonB-dependent receptor
XSP_000107	COG0662	Cupin 2, conserved barrel domain protein
XSP_000110	COG3284	Transcriptional regulator
XSP_000111	COG1012	belongs to the aldehyde dehydrogenase family
XSP_000117	COG1304	FMN binding
XSP_000118	COG4585	Histidine kinase
XSP_000119	COG2197	response regulator
XSP_000123	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XSP_000151	COG0366	Alpha amylase catalytic
XSP_000152	COG0366	Alpha amylase catalytic
XSP_000153	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XSP_000160	COG2755	lipolytic protein G-D-S-L family
XSP_000162	COG2755	lipolytic protein G-D-S-L family
XSP_000162	COG0657	acetylesterase activity
XSP_000164	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XSP_000167	COG3507	Belongs to the glycosyl hydrolase 43 family
XSP_000168	COG1609	Transcriptional regulator
XSP_000169	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XSP_000170	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_000172	COG2755	lipolytic protein G-D-S-L family
XSP_000176	COG3186	Phenylalanine-4-hydroxylase
XSP_000177	COG1522	sequence-specific DNA binding
XSP_000179	COG1752	Esterase of the alpha-beta hydrolase superfamily
XSP_000181	COG1119	ATPase activity
XSP_000184	COG0517	IMP dehydrogenase activity
XSP_000184	COG1125	glycine betaine transport
XSP_000187	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XSP_000188	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
XSP_000194	COG0489	protein tyrosine kinase activity
XSP_000195	COG2062	phosphohistidine phosphatase, SixA
XSP_000197	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XSP_000202	COG1881	PFAM PEBP family protein
XSP_000205	COG0174	glutamine synthetase
XSP_000206	COG0347	Belongs to the P(II) protein family
XSP_000207	COG0004	ammonium transporteR
XSP_000208	COG3852	Histidine kinase
XSP_000209	COG2204	response regulator
XSP_000210	COG2032	superoxide dismutase activity
XSP_000211	COG2032	superoxide dismutase activity
XSP_000212	COG0346	lactoylglutathione lyase activity
XSP_000214	COG0183	Belongs to the thiolase family
XSP_000222	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XSP_000224	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XSP_000226	COG0028	Belongs to the TPP enzyme family
XSP_000227	COG2205	protein histidine kinase activity
XSP_000232	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XSP_000235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XSP_000236	COG3177	Filamentation induced by cAMP protein fic
XSP_000237	COG0596	Alpha beta hydrolase
XSP_000238	COG0727	PFAM Uncharacterised protein family (UPF0153)
XSP_000239	COG0318	PFAM AMP-dependent synthetase and ligase
XSP_000240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XSP_000243	COG1181	Belongs to the D-alanine--D-alanine ligase family
XSP_000247	COG0564	pseudouridine synthase activity
XSP_000251	COG1446	asparaginase
XSP_000252	COG0339	signal peptide processing
XSP_000253	COG0681	Belongs to the peptidase S26 family
XSP_000256	COG0475	glutathione-regulated potassium exporter activity
XSP_000257	COG0583	DNA-binding transcription factor activity
XSP_000258	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XSP_000259	COG2224	Isocitrate lyase
XSP_000260	COG5001	Diguanylate cyclase
XSP_000265	COG4770	biotin carboxylase activity
XSP_000266	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XSP_000267	COG1960	acyl-CoA dehydrogenase activity
XSP_000278	COG0523	cobalamin synthesis protein
XSP_000280	COG0697	spore germination
XSP_000282	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XSP_000284	COG1846	Transcriptional regulator
XSP_000285	COG1764	response to oxidative stress
XSP_000290	COG0656	L-ascorbic acid biosynthetic process
XSP_000291	COG2130	NADP-dependent
XSP_000292	COG0667	Aldo Keto reductase
XSP_000294	COG1187	pseudouridine synthase activity
XSP_000296	COG1643	Atp-dependent helicase
XSP_000297	COG0840	transmembrane signaling receptor activity
XSP_000299	COG4807	Protein conserved in bacteria
XSP_000300	COG2351	hydroxyisourate hydrolase activity
XSP_000301	COG2072	flavoprotein involved in K transport
XSP_000305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XSP_000318	COG0084	hydrolase, TatD family'
XSP_000320	COG0583	DNA-binding transcription factor activity
XSP_000321	COG2814	Major facilitator Superfamily
XSP_000325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XSP_000326	COG1902	pentaerythritol trinitrate reductase activity
XSP_000330	COG2223	nitrite transmembrane transporter activity
XSP_000332	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XSP_000333	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XSP_000334	COG0583	DNA-binding transcription factor activity
XSP_000339	COG0702	epimerase
XSP_000340	COG1733	regulation of RNA biosynthetic process
XSP_000342	COG0840	transmembrane signaling receptor activity
XSP_000354	COG0129	dihydroxy-acid dehydratase activity
XSP_000357	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XSP_000358	COG2814	Major facilitator Superfamily
XSP_000367	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XSP_000368	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XSP_000374	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XSP_000375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XSP_000377	COG3485	protocatechuate 3,4-dioxygenase
XSP_000378	COG3485	protocatechuate 3,4-dioxygenase
XSP_000380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XSP_000381	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XSP_000383	COG1414	Transcriptional regulator
XSP_000387	COG0445	tRNA wobble uridine modification
XSP_000397	COG0156	8-amino-7-oxononanoate synthase activity
XSP_000398	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XSP_000399	COG1040	competence protein
XSP_000400	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XSP_000407	COG3264	Mechanosensitive ion channel
XSP_000407	COG1511	domain protein
XSP_000409	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XSP_000410	COG2354	Protein conserved in bacteria
XSP_000412	COG0297	glycogen (starch) synthase activity
XSP_000413	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XSP_000414	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XSP_000419	COG0702	epimerase
XSP_000420	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_000427	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XSP_000429	COG4221	oxidoreductase activity
XSP_000432	COG0513	Belongs to the DEAD box helicase family
XSP_000433	COG0508	dehydrogenase complex catalyzes the overall conversion of
XSP_000436	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XSP_000439	COG3104	oligopeptide transport
XSP_000443	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XSP_000445	COG1320	monovalent cation:proton antiporter activity
XSP_000446	COG2212	antiporter activity
XSP_000448	COG0651	ATP synthesis coupled electron transport
XSP_000449	COG1006	Multisubunit Na H antiporter MnhC subunit
XSP_000450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XSP_000450	COG2111	Na H antiporter
XSP_000457	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XSP_000461	COG1597	lipid kinase activity
XSP_000467	COG0840	transmembrane signaling receptor activity
XSP_000468	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_000469	COG1063	alcohol dehydrogenase
XSP_000470	COG1252	NADH dehydrogenase
XSP_000474	COG0840	transmembrane signaling receptor activity
XSP_000476	COG2207	Transcriptional regulator
XSP_000484	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XSP_000485	COG0134	indole-3-glycerol-phosphate synthase activity
XSP_000487	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XSP_000490	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XSP_000492	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XSP_000495	COG1051	belongs to the nudix hydrolase family
XSP_000503	COG0316	Belongs to the HesB IscA family
XSP_000506	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XSP_000511	COG2814	Major facilitator Superfamily
XSP_000512	COG1289	transmembrane transporter activity
XSP_000513	COG0151	Belongs to the GarS family
XSP_000514	COG0138	bifunctional purine biosynthesis protein purh
XSP_000517	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XSP_000521	COG2264	protein methyltransferase activity
XSP_000524	COG0439	Biotin carboxylase
XSP_000526	COG0511	ligase activity, forming carbon-carbon bonds
XSP_000527	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XSP_000529	COG1324	tolerance protein
XSP_000530	COG2356	endonuclease I
XSP_000535	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XSP_000540	COG3712	iron ion homeostasis
XSP_000546	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XSP_000551	COG2353	YceI-like domain
XSP_000552	COG2375	cellular response to nickel ion
XSP_000555	COG3052	prosthetic group binding
XSP_000562	COG1802	Transcriptional regulator
XSP_000563	COG0546	phosphoglycolate phosphatase activity
XSP_000571	COG0326	Molecular chaperone. Has ATPase activity
XSP_000575	COG0210	DNA helicase
XSP_000592	COG1595	DNA-templated transcription, initiation
XSP_000594	COG4206	TonB-dependent receptor
XSP_000607	COG0435	Glutathione S-transferase
XSP_000615	COG0823	Involved in the tonB-independent uptake of proteins
XSP_000615	COG1506	peptidase
XSP_000617	COG3706	GGDEF domain
XSP_000621	COG0697	spore germination
XSP_000624	COG1113	amino acid transport
XSP_000636	COG0840	transmembrane signaling receptor activity
XSP_000637	COG5297	Belongs to the glycosyl hydrolase family 6
XSP_000637	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XSP_000638	COG0659	secondary active sulfate transmembrane transporter activity
XSP_000639	COG3706	GGDEF domain
XSP_000641	COG2943	transferase activity, transferring hexosyl groups
XSP_000643	COG3275	phosphorelay sensor kinase activity
XSP_000645	COG0181	hydroxymethylbilane synthase activity
XSP_000650	COG1505	serine-type exopeptidase activity
XSP_000653	COG2832	Protein of unknown function (DUF454)
XSP_000655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XSP_000659	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XSP_000660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XSP_000665	COG2226	methyltransferase
XSP_000666	COG5001	Diguanylate cyclase
XSP_000666	COG3300	MHYT domain
XSP_000667	COG0308	aminopeptidase N
XSP_000676	COG3284	Transcriptional regulator
XSP_000677	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XSP_000678	COG1077	Cell shape determining protein MreB Mrl
XSP_000679	COG1792	Involved in formation and maintenance of cell shape
XSP_000682	COG0772	Belongs to the SEDS family
XSP_000684	COG2951	lytic endotransglycosylase activity
XSP_000685	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XSP_000686	COG1686	Belongs to the peptidase S11 family
XSP_000689	COG2921	Belongs to the UPF0250 family
XSP_000690	COG0321	lipoyl(octanoyl) transferase activity
XSP_000691	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XSP_000694	COG0583	DNA-binding transcription factor activity
XSP_000696	COG1051	belongs to the nudix hydrolase family
XSP_000696	COG1056	cytidyltransferase-related domain
XSP_000703	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XSP_000704	COG0673	inositol 2-dehydrogenase activity
XSP_000705	COG2823	Periplasmic or secreted lipoprotein
XSP_000706	COG4251	negative regulation of phosphorylation
XSP_000707	COG0784	Response regulator, receiver
XSP_000708	COG4191	Histidine kinase
XSP_000709	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XSP_000710	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_000719	COG1459	type II secretion system
XSP_000720	COG2165	general secretion pathway protein
XSP_000723	COG4795	General secretion pathway protein
XSP_000724	COG3156	type II secretion system protein K
XSP_000729	COG3250	beta-galactosidase activity
XSP_000732	COG2188	Transcriptional regulator
XSP_000734	COG1609	Transcriptional regulator
XSP_000735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XSP_000736	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XSP_000739	COG0617	tRNA 3'-terminal CCA addition
XSP_000743	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XSP_000745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XSP_000747	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XSP_000750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XSP_000751	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XSP_000754	COG2205	protein histidine kinase activity
XSP_000755	COG0745	RESPONSE REGULATOR receiver
XSP_000758	COG3920	Histidine kinase
XSP_000761	COG3791	Glutathione-dependent formaldehyde-activating
XSP_000762	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
XSP_000763	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XSP_000764	COG0697	spore germination
XSP_000768	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XSP_000769	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XSP_000771	COG2205	protein histidine kinase activity
XSP_000772	COG0745	RESPONSE REGULATOR receiver
XSP_000773	COG0277	FAD linked oxidase domain protein
XSP_000774	COG1988	membrane-bound metal-dependent
XSP_000775	COG0792	nuclease activity
XSP_000781	COG0275	rRNA processing
XSP_000782	COG3116	cell division
XSP_000784	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XSP_000785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XSP_000789	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XSP_000790	COG1181	Belongs to the D-alanine--D-alanine ligase family
XSP_000791	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XSP_000796	COG0739	heme binding
XSP_000797	COG0653	protein targeting
XSP_000799	COG0494	nUDIX hydrolase
XSP_000802	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XSP_000804	COG3321	synthase
XSP_000804	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_000804	COG0604	alcohol dehydrogenase
XSP_000809	COG0366	Alpha amylase catalytic
XSP_000814	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XSP_000819	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XSP_000822	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XSP_000823	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XSP_000825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XSP_000826	COG0667	Aldo Keto reductase
XSP_000828	COG4771	TonB-dependent receptor
XSP_000832	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XSP_000833	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XSP_000835	COG2175	clavaminate synthase activity
XSP_000837	COG4181	ATPase activity
XSP_000840	COG0642	Histidine kinase
XSP_000842	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XSP_000849	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XSP_000850	COG2967	ApaG domain
XSP_000851	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XSP_000852	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XSP_000854	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XSP_000855	COG0123	including yeast histone deacetylase and acetoin utilization protein
XSP_000856	COG2096	Adenosyltransferase
XSP_000858	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XSP_000859	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XSP_000865	COG3384	dioxygenase
XSP_000866	COG0583	DNA-binding transcription factor activity
XSP_000867	COG0318	PFAM AMP-dependent synthetase and ligase
XSP_000869	COG1024	Enoyl-CoA hydratase
XSP_000873	COG3386	PFAM SMP-30 Gluconolaconase
XSP_000879	COG0697	spore germination
XSP_000880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XSP_000884	COG2205	protein histidine kinase activity
XSP_000884	COG5002	protein histidine kinase activity
XSP_000884	COG0784	Response regulator, receiver
XSP_000885	COG2197	response regulator
XSP_000887	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XSP_000889	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XSP_000890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XSP_000891	COG0583	DNA-binding transcription factor activity
XSP_000892	COG3634	alkyl hydroperoxide reductase activity
XSP_000894	COG2890	protein-(glutamine-N5) methyltransferase activity
XSP_000898	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XSP_000898	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XSP_000904	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XSP_000909	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XSP_000913	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XSP_000914	COG1404	Belongs to the peptidase S8 family
XSP_000915	COG1404	Belongs to the peptidase S8 family
XSP_000916	COG1404	Belongs to the peptidase S8 family
XSP_000921	COG1295	ribonuclease BN
XSP_000922	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XSP_000923	COG1254	Belongs to the acylphosphatase family
XSP_000926	COG0521	Mo-molybdopterin cofactor biosynthetic process
XSP_000929	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XSP_000931	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XSP_000934	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XSP_000935	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XSP_000936	COG0193	aminoacyl-tRNA hydrolase activity
XSP_000937	COG0012	GTP binding
XSP_000941	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XSP_000943	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XSP_000944	COG0250	Participates in transcription elongation, termination and antitermination
XSP_000945	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XSP_000946	COG0081	regulation of translation
XSP_000947	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XSP_000948	COG0222	ribosome binding
XSP_000950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XSP_000951	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XSP_000953	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XSP_000954	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XSP_000955	COG0051	transcription antitermination factor activity, RNA binding
XSP_000959	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XSP_000961	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XSP_000964	COG0255	Belongs to the universal ribosomal protein uL29 family
XSP_000967	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XSP_000974	COG1841	ribosomal large subunit assembly
XSP_000976	COG0201	protein transport
XSP_000981	COG0203	ribosomal protein L17
XSP_000983	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XSP_000985	COG0154	amidase activity
XSP_000988	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XSP_000990	COG0625	glutathione transferase activity
XSP_000993	COG1902	pentaerythritol trinitrate reductase activity
XSP_000993	COG0446	pyridine nucleotide-disulphide oxidoreductase
XSP_000994	COG0604	alcohol dehydrogenase
XSP_000995	COG2885	chlorophyll binding
XSP_001000	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XSP_001001	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XSP_001002	COG4208	sulfate ABC transporter
XSP_001003	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XSP_001005	COG1063	alcohol dehydrogenase
XSP_001009	COG0406	alpha-ribazole phosphatase activity
XSP_001011	COG0285	dihydrofolate synthase activity
XSP_001015	COG2833	Protein of unknown function (DUF455)
XSP_001016	COG3291	Pkd domain containing protein
XSP_001018	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XSP_001019	COG0671	phosphoesterase, PA-phosphatase related
XSP_001020	COG0438	transferase activity, transferring glycosyl groups
XSP_001022	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XSP_001025	COG4783	chaperone-mediated protein folding
XSP_001028	COG0473	3-isopropylmalate dehydrogenase activity
XSP_001061	COG0740	serine-type endopeptidase activity
XSP_001095	COG0544	peptidyl-prolyl cis-trans isomerase activity
XSP_001097	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XSP_001103	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XSP_001105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XSP_001107	COG0328	RNA-DNA hybrid ribonuclease activity
XSP_001109	COG0631	protein serine/threonine phosphatase activity
XSP_001112	COG0859	PFAM glycosyl transferase family 9
XSP_001114	COG1234	tRNA 3'-trailer cleavage
XSP_001115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XSP_001116	COG0315	cyclic pyranopterin monophosphate synthase activity
XSP_001117	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XSP_001118	COG0314	molybdopterin synthase activity
XSP_001122	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XSP_001123	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XSP_001124	COG0537	adenosine 5'-monophosphoramidase activity
XSP_001128	COG0714	Associated with various cellular activities
XSP_001132	COG0424	maF-like protein
XSP_001133	COG1399	metal-binding, possibly nucleic acid-binding protein
XSP_001134	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XSP_001135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XSP_001137	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XSP_001138	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_001141	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XSP_001142	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XSP_001147	COG3829	transcription factor binding
XSP_001152	COG3609	addiction module antidote protein, CC2985 family
XSP_001157	COG2373	Large extracellular alpha-helical protein
XSP_001163	COG4953	penicillin-binding protein 1C
XSP_001165	COG0678	peroxiredoxin activity
XSP_001169	COG0330	HflC and HflK could
XSP_001170	COG0330	HflC and HflK could
XSP_001178	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_001179	COG1309	transcriptional regulator
XSP_001181	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XSP_001188	COG1309	transcriptional regulator
XSP_001190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XSP_001192	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_001194	COG3537	Alpha-1,2-mannosidase
XSP_001201	COG2323	membrane
XSP_001203	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_001204	COG2271	Major facilitator Superfamily
XSP_001210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XSP_001211	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XSP_001212	COG2080	2 iron, 2 sulfur cluster binding
XSP_001221	COG0587	DNA-directed DNA polymerase activity
XSP_001222	COG1297	OPT oligopeptide transporter protein
XSP_001226	COG1506	peptidase
XSP_001226	COG0823	Involved in the tonB-independent uptake of proteins
XSP_001231	COG2207	Transcriptional regulator
XSP_001231	COG1917	Cupin 2, conserved barrel domain protein
XSP_001232	COG0753	catalase activity
XSP_001233	COG0656	L-ascorbic acid biosynthetic process
XSP_001235	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XSP_001235	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XSP_001236	COG2814	Major facilitator Superfamily
XSP_001240	COG2194	sulfuric ester hydrolase activity
XSP_001242	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XSP_001243	COG0745	RESPONSE REGULATOR receiver
XSP_001244	COG5002	protein histidine kinase activity
XSP_001247	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XSP_001248	COG2894	cell division
XSP_001249	COG0850	regulation of cytokinetic process
XSP_001251	COG4585	Histidine kinase
XSP_001252	COG2197	response regulator
XSP_001255	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XSP_001263	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XSP_001265	COG1595	DNA-templated transcription, initiation
XSP_001267	COG1946	Acyl-CoA thioesterase
XSP_001268	COG1024	Enoyl-CoA hydratase
XSP_001270	COG0824	Thioesterase
XSP_001271	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XSP_001273	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XSP_001274	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XSP_001276	COG0728	peptidoglycan biosynthetic process
XSP_001277	COG0196	riboflavin kinase activity
XSP_001279	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XSP_001280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XSP_001283	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XSP_001284	COG1845	cytochrome c oxidase, subunit III
XSP_001285	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XSP_001288	COG3152	Membrane
XSP_001290	COG2207	Transcriptional regulator
XSP_001291	COG0326	Molecular chaperone. Has ATPase activity
XSP_001293	COG1366	Belongs to the anti-sigma-factor antagonist family
XSP_001294	COG1366	Belongs to the anti-sigma-factor antagonist family
XSP_001295	COG2172	sigma factor antagonist activity
XSP_001299	COG4771	TonB-dependent receptor
XSP_001301	COG5507	3-demethylubiquinone-9 3-methyltransferase
XSP_001302	COG2205	protein histidine kinase activity
XSP_001304	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XSP_001305	COG4999	Histidine kinase
XSP_001305	COG3850	Histidine kinase
XSP_001305	COG2205	protein histidine kinase activity
XSP_001305	COG3437	response regulator, receiver
XSP_001306	COG0784	Response regulator, receiver
XSP_001306	COG4191	Histidine kinase
XSP_001313	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XSP_001314	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XSP_001315	COG2070	2-Nitropropane dioxygenase
XSP_001319	COG0336	Belongs to the RNA methyltransferase TrmD family
XSP_001321	COG0534	Mate efflux family protein
XSP_001323	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XSP_001325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XSP_001326	COG1309	transcriptional regulator
XSP_001332	COG3279	Response regulator of the LytR AlgR family
XSP_001334	COG0583	DNA-binding transcription factor activity
XSP_001335	COG0028	Belongs to the TPP enzyme family
XSP_001338	COG3250	beta-galactosidase activity
XSP_001339	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XSP_001341	COG1396	sequence-specific DNA binding
XSP_001341	COG3800	Transcriptional regulator
XSP_001343	COG1960	acyl-CoA dehydrogenase activity
XSP_001349	COG1250	3-hydroxyacyl-CoA dehydrogenase
XSP_001349	COG1024	Enoyl-CoA hydratase
XSP_001352	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XSP_001353	COG0481	GTPase activity
XSP_001358	COG1381	Involved in DNA repair and RecF pathway recombination
XSP_001361	COG2954	triphosphatase activity
XSP_001362	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XSP_001363	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
XSP_001364	COG3046	protein related to deoxyribodipyrimidine photolyase
XSP_001365	COG1472	Belongs to the glycosyl hydrolase 3 family
XSP_001367	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XSP_001368	COG1278	Cold shock
XSP_001369	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XSP_001371	COG1201	RNA secondary structure unwinding
XSP_001372	COG1793	dna ligase
XSP_001374	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XSP_001374	COG1793	dna ligase
XSP_001380	COG0183	Belongs to the thiolase family
XSP_001384	COG1451	nucleotide metabolic process
XSP_001385	COG5487	UPF0391 membrane protein
XSP_001387	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XSP_001391	COG1047	Peptidyl-prolyl cis-trans
XSP_001393	COG2824	Alkylphosphonate utilization operon protein PhnA
XSP_001397	COG1902	pentaerythritol trinitrate reductase activity
XSP_001398	COG2814	Major facilitator Superfamily
XSP_001404	COG0392	lysyltransferase activity
XSP_001404	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XSP_001406	COG0251	oxidation-reduction process
XSP_001407	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XSP_001410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XSP_001415	COG1595	DNA-templated transcription, initiation
XSP_001418	COG2878	Part of a membrane complex involved in electron transport
XSP_001420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XSP_001420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XSP_001423	COG1131	(ABC) transporter
XSP_001424	COG0346	lactoylglutathione lyase activity
XSP_001425	COG0833	amino acid
XSP_001426	COG2040	homocysteine
XSP_001430	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XSP_001434	COG1695	Transcriptional regulator
XSP_001441	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XSP_001442	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XSP_001444	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XSP_001447	COG0750	zinc metalloprotease
XSP_001448	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XSP_001449	COG0575	Belongs to the CDS family
XSP_001450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XSP_001451	COG0233	cytoplasmic translational termination
XSP_001452	COG0528	UMP kinase activity
XSP_001454	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XSP_001455	COG0052	Belongs to the universal ribosomal protein uS2 family
XSP_001466	COG1393	Belongs to the ArsC family
XSP_001467	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XSP_001469	COG0367	asparagine synthase
XSP_001471	COG4774	siderophore transport
XSP_001479	COG1566	PFAM secretion protein HlyD family protein
XSP_001480	COG2814	Major facilitator Superfamily
XSP_001486	COG3104	oligopeptide transport
XSP_001492	COG0339	signal peptide processing
XSP_001493	COG0386	Belongs to the glutathione peroxidase family
XSP_001499	COG0288	reversible hydration of carbon dioxide
XSP_001501	COG2839	Protein conserved in bacteria
XSP_001505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XSP_001506	COG0084	hydrolase, TatD family'
XSP_001509	COG1960	acyl-CoA dehydrogenase activity
XSP_001512	COG0367	asparagine synthase
XSP_001514	COG0305	Participates in initiation and elongation during chromosome replication
XSP_001515	COG0415	Belongs to the DNA photolyase family
XSP_001517	COG0583	DNA-binding transcription factor activity
XSP_001520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XSP_001524	COG3706	GGDEF domain
XSP_001526	COG3706	GGDEF domain
XSP_001536	COG2003	Belongs to the UPF0758 family
XSP_001572	COG2814	Major facilitator Superfamily
XSP_001581	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XSP_001584	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XSP_001586	COG0497	DNA recombination
XSP_001587	COG1420	regulation of RNA biosynthetic process
XSP_001588	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XSP_001589	COG0443	Heat shock 70 kDa protein
XSP_001590	COG0484	heat shock protein binding
XSP_001591	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XSP_001597	COG0583	DNA-binding transcription factor activity
XSP_001598	COG1132	(ABC) transporter
XSP_001605	COG2850	peptidyl-arginine hydroxylation
XSP_001607	COG1253	flavin adenine dinucleotide binding
XSP_001613	COG1131	(ABC) transporter
XSP_001614	COG1725	Transcriptional regulator
XSP_001616	COG0386	Belongs to the glutathione peroxidase family
XSP_001619	COG2900	Belongs to the SlyX family
XSP_001624	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XSP_001626	COG0646	methionine synthase
XSP_001626	COG1410	methionine synthase
XSP_001627	COG0646	methionine synthase
XSP_001627	COG1410	methionine synthase
XSP_001628	COG2226	methyltransferase
XSP_001629	COG1960	acyl-CoA dehydrogenase activity
XSP_001633	COG0557	exoribonuclease II activity
XSP_001635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XSP_001637	COG3706	GGDEF domain
XSP_001638	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XSP_001640	COG0704	Plays a role in the regulation of phosphate uptake
XSP_001641	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XSP_001642	COG0581	inorganic phosphate transmembrane transporter activity
XSP_001643	COG0573	inorganic phosphate transmembrane transporter activity
XSP_001644	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XSP_001649	COG0659	secondary active sulfate transmembrane transporter activity
XSP_001650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XSP_001652	COG1024	Enoyl-CoA hydratase
XSP_001654	COG0494	nUDIX hydrolase
XSP_001663	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XSP_001668	COG2925	Exonuclease
XSP_001669	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XSP_001670	COG3844	kynureninase activity
XSP_001673	COG0288	reversible hydration of carbon dioxide
XSP_001674	COG2808	Putative FMN-binding domain
XSP_001677	COG0017	Asparaginyl-tRNA synthetase
XSP_001678	COG0316	Belongs to the HesB IscA family
XSP_001684	COG3115	cell septum assembly
XSP_001686	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XSP_001687	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XSP_001688	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XSP_001690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XSP_001692	COG4993	Dehydrogenase
XSP_001695	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XSP_001697	COG2986	histidine ammonia-lyase
XSP_001698	COG1228	amidohydrolase
XSP_001705	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XSP_001706	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XSP_001707	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XSP_001708	COG1605	Chorismate mutase
XSP_001708	COG0077	Prephenate dehydratase
XSP_001709	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XSP_001712	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XSP_001713	COG0583	DNA-binding transcription factor activity
XSP_001718	COG0322	excinuclease ABC activity
XSP_001720	COG1595	DNA-templated transcription, initiation
XSP_001721	COG3712	iron ion homeostasis
XSP_001723	COG1858	cytochrome C peroxidase
XSP_001725	COG2832	Protein of unknown function (DUF454)
XSP_001730	COG3712	iron ion homeostasis
XSP_001731	COG1595	DNA-templated transcription, initiation
XSP_001733	COG2003	Belongs to the UPF0758 family
XSP_001737	COG1074	ATP-dependent DNA helicase activity
XSP_001752	COG3685	Protein conserved in bacteria
XSP_001757	COG0840	transmembrane signaling receptor activity
XSP_001760	COG0840	transmembrane signaling receptor activity
XSP_001766	COG0840	transmembrane signaling receptor activity
XSP_001770	COG4191	Histidine kinase
XSP_001770	COG0784	Response regulator, receiver
XSP_001771	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XSP_001772	COG0784	Response regulator, receiver
XSP_001772	COG4191	Histidine kinase
XSP_001775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XSP_001780	COG1404	Belongs to the peptidase S8 family
XSP_001782	COG1595	DNA-templated transcription, initiation
XSP_001792	COG2244	polysaccharide biosynthetic process
XSP_001796	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XSP_001798	COG2226	methyltransferase
XSP_001799	COG0297	glycogen (starch) synthase activity
XSP_001800	COG0438	transferase activity, transferring glycosyl groups
XSP_001803	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XSP_001804	COG1132	(ABC) transporter
XSP_001805	COG0477	Major facilitator Superfamily
XSP_001806	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XSP_001809	COG1253	flavin adenine dinucleotide binding
XSP_001816	COG0504	CTP synthase activity
XSP_001817	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XSP_001818	COG0148	phosphopyruvate hydratase activity
XSP_001820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XSP_001821	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XSP_001822	COG0585	pseudouridine synthase activity
XSP_001823	COG2840	Smr protein MutS2
XSP_001824	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XSP_001825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XSP_001826	COG1238	metal cluster binding
XSP_001829	COG1534	Rna-binding protein
XSP_001830	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XSP_001832	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XSP_001833	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XSP_001835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XSP_001836	COG1546	Belongs to the CinA family
XSP_001838	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XSP_001840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XSP_001841	COG2137	regulation of response to DNA damage stimulus
XSP_001842	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XSP_001843	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XSP_001846	COG1741	Belongs to the pirin family
XSP_001847	COG0583	DNA-binding transcription factor activity
XSP_001852	COG0352	thiamine-phosphate diphosphorylase activity
XSP_001852	COG0351	phosphomethylpyrimidine kinase
XSP_001855	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XSP_001856	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XSP_001859	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XSP_001861	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XSP_001862	COG3734	2-keto-3-deoxy-galactonokinase
XSP_001864	COG4948	Mandelate Racemase Muconate Lactonizing
XSP_001865	COG0800	Aldolase
XSP_001872	COG1501	Belongs to the glycosyl hydrolase 31 family
XSP_001874	COG1070	Carbohydrate kinase
XSP_001875	COG2115	Belongs to the xylose isomerase family
XSP_001876	COG0477	Major facilitator Superfamily
XSP_001880	COG0860	N-Acetylmuramoyl-L-alanine amidase
XSP_001885	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XSP_001886	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XSP_001892	COG1472	Belongs to the glycosyl hydrolase 3 family
XSP_001894	COG2203	Gaf domain
XSP_001894	COG4251	negative regulation of phosphorylation
XSP_001894	COG5001	Diguanylate cyclase
XSP_001894	COG3706	GGDEF domain
XSP_001895	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XSP_001896	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XSP_001898	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XSP_001899	COG0671	phosphoesterase, PA-phosphatase related
XSP_001901	COG1794	racemase activity, acting on amino acids and derivatives
XSP_001902	COG0697	spore germination
XSP_001903	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XSP_001907	COG1012	belongs to the aldehyde dehydrogenase family
XSP_001913	COG1215	transferase activity, transferring glycosyl groups
XSP_001914	COG0726	polysaccharide deacetylase
XSP_001914	COG1649	PFAM Uncharacterised BCR, COG1649
XSP_001922	COG0460	homoserine dehydrogenase
XSP_001922	COG0527	aspartate kinase activity
XSP_001927	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XSP_001928	COG0124	histidyl-tRNA synthetase
XSP_001930	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XSP_001932	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XSP_001933	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XSP_001933	COG0131	Imidazoleglycerol-phosphate dehydratase
XSP_001934	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XSP_001935	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XSP_001937	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XSP_001937	COG0140	phosphoribosyl-ATP diphosphatase activity
XSP_001941	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XSP_001943	COG0531	amino acid
XSP_001944	COG0531	amino acid
XSP_001946	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XSP_001947	COG0277	FAD linked oxidase domain protein
XSP_001951	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XSP_001959	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XSP_001960	COG2258	MOSC domain
XSP_001962	COG0505	Belongs to the CarA family
XSP_001964	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XSP_001965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XSP_001967	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XSP_001972	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XSP_001974	COG0784	Response regulator, receiver
XSP_001974	COG2198	Histidine kinase
XSP_001974	COG2205	protein histidine kinase activity
XSP_001975	COG1024	Enoyl-CoA hydratase
XSP_001976	COG0318	PFAM AMP-dependent synthetase and ligase
XSP_001982	COG2267	carboxylic ester hydrolase activity
XSP_001987	COG0840	transmembrane signaling receptor activity
XSP_001989	COG0835	chemotaxis
XSP_001991	COG0840	transmembrane signaling receptor activity
XSP_001992	COG0840	transmembrane signaling receptor activity
XSP_001993	COG0840	transmembrane signaling receptor activity
XSP_001995	COG0840	transmembrane signaling receptor activity
XSP_001997	COG0840	transmembrane signaling receptor activity
XSP_002001	COG2198	Histidine kinase
XSP_002001	COG0643	Histidine kinase
XSP_002002	COG0745	RESPONSE REGULATOR receiver
XSP_002004	COG0835	chemotaxis
XSP_002006	COG1360	Flagellar Motor Protein
XSP_002007	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XSP_002009	COG0583	DNA-binding transcription factor activity
XSP_002010	COG2814	Major facilitator Superfamily
XSP_002011	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_002021	COG0784	Response regulator, receiver
XSP_002021	COG2198	Histidine kinase
XSP_002021	COG0643	Histidine kinase
XSP_002031	COG3300	MHYT domain
XSP_002031	COG5001	Diguanylate cyclase
XSP_002032	COG1684	flagellar biosynthetic protein fliR
XSP_002045	COG1677	Flagellar hook-basal body complex protein FliE
XSP_002046	COG0438	transferase activity, transferring glycosyl groups
XSP_002046	COG1216	Glycosyl transferase, family 2
XSP_002048	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XSP_002054	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_002055	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_002056	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XSP_002060	COG2201	protein-glutamate methylesterase activity
XSP_002066	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XSP_002067	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XSP_002070	COG1705	Flagellar rod assembly protein muramidase FlgJ
XSP_002070	COG3951	Flagellar rod assembly protein muramidase FlgJ
XSP_002071	COG1706	bacterial-type flagellum-dependent cell motility
XSP_002074	COG4787	bacterial-type flagellum-dependent cell motility
XSP_002076	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XSP_002077	COG1558	bacterial-type flagellum-dependent cell motility
XSP_002079	COG0784	Response regulator, receiver
XSP_002079	COG0835	chemotaxis
XSP_002083	COG4191	Histidine kinase
XSP_002089	COG2915	High frequency lysogenization protein hflD homolog
XSP_002090	COG0482	sulfurtransferase activity
XSP_002094	COG0542	response to heat
XSP_002096	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XSP_002098	COG0492	ferredoxin-NADP+ reductase activity
XSP_002099	COG1674	ftsk spoiiie
XSP_002102	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XSP_002103	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XSP_002104	COG0183	Belongs to the thiolase family
XSP_002105	COG1024	Enoyl-CoA hydratase
XSP_002105	COG1250	3-hydroxyacyl-CoA dehydrogenase
XSP_002108	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XSP_002110	COG1426	Protein conserved in bacteria
XSP_002112	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XSP_002113	COG1160	GTP binding
XSP_002114	COG0303	'Molybdopterin
XSP_002115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XSP_002118	COG0708	Exodeoxyribonuclease III
XSP_002120	COG0303	'Molybdopterin
XSP_002121	COG0746	molybdenum cofactor guanylyltransferase activity
XSP_002123	COG1648	precorrin-2 dehydrogenase activity
XSP_002123	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XSP_002125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XSP_002127	COG2223	nitrite transmembrane transporter activity
XSP_002128	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XSP_002130	COG0243	molybdopterin cofactor binding
XSP_002134	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
XSP_002136	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XSP_002138	COG0579	oxidoreductase
XSP_002142	COG5001	Diguanylate cyclase
XSP_002151	COG0784	Response regulator, receiver
XSP_002151	COG4191	Histidine kinase
XSP_002157	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XSP_002159	COG0840	transmembrane signaling receptor activity
XSP_002160	COG0583	DNA-binding transcription factor activity
XSP_002166	COG0583	DNA-binding transcription factor activity
XSP_002168	COG3781	membrane
XSP_002173	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_002194	COG0346	lactoylglutathione lyase activity
XSP_002195	COG1136	(ABC) transporter
XSP_002195	COG4591	ABC-type transport system involved in lipoprotein release permease component
XSP_002197	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
XSP_002206	COG0653	protein targeting
XSP_002218	COG0428	transporter
XSP_002219	COG0564	pseudouridine synthase activity
XSP_002220	COG1530	ribonuclease E activity
XSP_002226	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XSP_002231	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XSP_002232	COG0322	excinuclease ABC activity
XSP_002234	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XSP_002235	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XSP_002237	COG1663	tetraacyldisaccharide 4'-kinase activity
XSP_002238	COG1132	(ABC) transporter
XSP_002240	COG0811	peptide transport
XSP_002243	COG1136	(ABC) transporter
XSP_002244	COG4591	ABC-type transport system involved in lipoprotein release permease component
XSP_002246	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XSP_002247	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XSP_002250	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XSP_002255	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XSP_002256	COG0837	glucose binding
XSP_002258	COG0129	dihydroxy-acid dehydratase activity
XSP_002259	COG0800	Aldolase
XSP_002278	COG0784	Response regulator, receiver
XSP_002278	COG5002	protein histidine kinase activity
XSP_002278	COG2205	protein histidine kinase activity
XSP_002279	COG2183	response to ionizing radiation
XSP_002281	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XSP_002281	COG0723	plastoquinol--plastocyanin reductase activity
XSP_002284	COG3243	poly(R)-hydroxyalkanoic acid synthase
XSP_002286	COG1183	phosphatidylcholine synthase activity
XSP_002287	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_002292	COG0668	transmembrane transport
XSP_002293	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XSP_002296	COG1914	H( )-stimulated, divalent metal cation uptake system
XSP_002304	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XSP_002306	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XSP_002307	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XSP_002310	COG0539	negative regulation of cytoplasmic translation
XSP_002311	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XSP_002314	COG2957	Belongs to the agmatine deiminase family
XSP_002315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XSP_002320	COG0395	ABC-type sugar transport system, permease component
XSP_002321	COG1175	transmembrane transport
XSP_002327	COG2350	Protein conserved in bacteria
XSP_002328	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XSP_002329	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XSP_002330	COG1187	pseudouridine synthase activity
XSP_002334	COG0436	Aminotransferase
XSP_002335	COG4133	protoheme IX ABC transporter activity
XSP_002339	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XSP_002340	COG1138	Cytochrome C-type biogenesis protein
XSP_002344	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XSP_002347	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XSP_002348	COG4988	ABC transporter
XSP_002350	COG1294	oxidase, subunit
XSP_002361	COG0165	Argininosuccinate lyase
XSP_002364	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XSP_002365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XSP_002366	COG0137	argininosuccinate synthase activity
XSP_002367	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XSP_002369	COG0215	cysteine-tRNA ligase activity
XSP_002370	COG2166	iron-sulfur cluster assembly
XSP_002374	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XSP_002378	COG4302	ethanolamine ammonia-lyase activity
XSP_002389	COG0402	S-adenosylhomocysteine deaminase activity
XSP_002391	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XSP_002392	COG1509	lysine 2,3-aminomutase activity
XSP_002393	COG5001	Diguanylate cyclase
XSP_002393	COG3300	MHYT domain
XSP_002396	COG0483	inositol monophosphate 1-phosphatase activity
XSP_002397	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XSP_002401	COG0513	Belongs to the DEAD box helicase family
XSP_002402	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XSP_002403	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XSP_002405	COG0625	glutathione transferase activity
XSP_002409	COG2081	HI0933 family
XSP_002412	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XSP_002413	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_002417	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XSP_002418	COG0860	N-Acetylmuramoyl-L-alanine amidase
XSP_002420	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XSP_002420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XSP_002421	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XSP_002424	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XSP_002429	COG2199	diguanylate cyclase activity
XSP_002430	COG0835	chemotaxis
XSP_002431	COG0840	transmembrane signaling receptor activity
XSP_002432	COG2094	Belongs to the DNA glycosylase MPG family
XSP_002433	COG1201	RNA secondary structure unwinding
XSP_002435	COG2969	positive regulation of protein catabolic process
XSP_002436	COG0625	glutathione transferase activity
XSP_002437	COG2857	Cytochrome c1
XSP_002438	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XSP_002439	COG0723	plastoquinol--plastocyanin reductase activity
XSP_002440	COG0741	lytic transglycosylase activity
XSP_002443	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XSP_002445	COG1702	phosphate starvation-inducible protein PhoH
XSP_002447	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XSP_002449	COG4535	Mg2 and Co2 transporter CorC
XSP_002452	COG1012	belongs to the aldehyde dehydrogenase family
XSP_002454	COG1177	transmembrane transport
XSP_002455	COG1176	ABC-type spermidine putrescine transport system, permease component I
XSP_002456	COG3842	ATPase activity
XSP_002460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XSP_002463	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XSP_002464	COG0174	glutamine synthetase
XSP_002465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XSP_002467	COG0477	Major facilitator Superfamily
XSP_002469	COG0243	molybdopterin cofactor binding
XSP_002471	COG2223	nitrite transmembrane transporter activity
XSP_002474	COG2733	membrane
XSP_002475	COG5002	protein histidine kinase activity
XSP_002475	COG2205	protein histidine kinase activity
XSP_002475	COG0784	Response regulator, receiver
XSP_002477	COG0477	Major facilitator Superfamily
XSP_002479	COG1902	pentaerythritol trinitrate reductase activity
XSP_002481	COG0604	alcohol dehydrogenase
XSP_002482	COG2902	Dehydrogenase
XSP_002484	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XSP_002485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XSP_002486	COG1609	Transcriptional regulator
XSP_002487	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XSP_002487	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XSP_002488	COG1105	Belongs to the carbohydrate kinase PfkB family
XSP_002489	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XSP_002489	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XSP_002497	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XSP_002499	COG1862	Preprotein translocase
XSP_002501	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XSP_002509	COG3291	Pkd domain containing protein
XSP_002510	COG0405	Gamma-glutamyltransferase
XSP_002511	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XSP_002514	COG0742	ribosomal rna small subunit methyltransferase
XSP_002515	COG0326	Molecular chaperone. Has ATPase activity
XSP_002517	COG4206	TonB-dependent receptor
XSP_002524	COG0531	amino acid
XSP_002527	COG0006	proline dipeptidase activity
XSP_002529	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XSP_002532	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XSP_002533	COG3938	Belongs to the proline racemase family
XSP_002535	COG0552	protein localization to endoplasmic reticulum
XSP_002537	COG1194	a g-specific adenine glycosylase
XSP_002539	COG4191	Histidine kinase
XSP_002539	COG0784	Response regulator, receiver
XSP_002546	COG1960	acyl-CoA dehydrogenase activity
XSP_002548	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XSP_002552	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XSP_002553	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XSP_002554	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XSP_002559	COG0438	transferase activity, transferring glycosyl groups
XSP_002561	COG0438	transferase activity, transferring glycosyl groups
XSP_002562	COG0438	transferase activity, transferring glycosyl groups
XSP_002572	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XSP_002572	COG0072	phenylalanine-tRNA ligase activity
XSP_002573	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XSP_002576	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XSP_002577	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XSP_002580	COG2211	Major facilitator Superfamily
XSP_002582	COG1082	Xylose isomerase domain protein TIM barrel
XSP_002584	COG0366	Alpha amylase catalytic
XSP_002586	COG3702	type iv secretory pathway
XSP_002590	COG2948	multi-organism process
XSP_002594	COG3505	Type IV secretory pathway VirD4
XSP_002597	COG0556	nucleotide-excision repair
XSP_002606	COG1611	Belongs to the LOG family
XSP_002608	COG2095	MarC family integral membrane protein
XSP_002609	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_002610	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XSP_002617	COG1185	polyribonucleotide nucleotidyltransferase activity
XSP_002618	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XSP_002619	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XSP_002620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XSP_002622	COG0195	Participates in both transcription termination and antitermination
XSP_002623	COG0779	Required for maturation of 30S ribosomal subunits
XSP_002625	COG1007	ATP synthesis coupled electron transport
XSP_002629	COG0839	Belongs to the complex I subunit 6 family
XSP_002631	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XSP_002633	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XSP_002634	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XSP_002636	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XSP_002638	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XSP_002642	COG4221	oxidoreductase activity
XSP_002648	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XSP_002649	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XSP_002652	COG0133	tryptophan synthase activity
XSP_002655	COG0101	tRNA pseudouridine synthase activity
XSP_002658	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XSP_002659	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XSP_002660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XSP_002662	COG2890	protein-(glutamine-N5) methyltransferase activity
XSP_002664	COG0688	phosphatidylethanolamine metabolic process
XSP_002666	COG0433	COG0433 Predicted ATPase
XSP_002668	COG0494	nUDIX hydrolase
XSP_002671	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XSP_002673	COG3620	sequence-specific DNA binding
XSP_002675	COG2336	PFAM SpoVT AbrB
XSP_002685	COG0717	Belongs to the dCTP deaminase family
XSP_002686	COG0489	protein tyrosine kinase activity
XSP_002689	COG3590	peptidase
XSP_002690	COG3590	peptidase
XSP_002694	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XSP_002696	COG2311	Membrane
XSP_002698	COG1047	Peptidyl-prolyl cis-trans
XSP_002699	COG0791	NLP P60 protein
XSP_002700	COG0791	NLP P60 protein
XSP_002704	COG1301	dicarboxylic acid transport
XSP_002705	COG1785	Belongs to the alkaline phosphatase family
XSP_002706	COG0037	tRNA processing
XSP_002707	COG1722	exodeoxyribonuclease VII activity
XSP_002708	COG0142	geranyltranstransferase activity
XSP_002709	COG4104	PAAR repeat-containing protein
XSP_002711	COG0312	modulator of DNA gyrase
XSP_002712	COG3028	Belongs to the UPF0307 family
XSP_002713	COG0312	modulator of DNA gyrase
XSP_002715	COG3164	Protein of unknown function
XSP_002716	COG1530	ribonuclease E activity
XSP_002717	COG0424	maF-like protein
XSP_002718	COG2968	Membrane
XSP_002720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XSP_002724	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XSP_002727	COG0495	leucyl-tRNA aminoacylation
XSP_002729	COG3118	belongs to the thioredoxin family
XSP_002739	COG1132	(ABC) transporter
XSP_002741	COG0475	glutathione-regulated potassium exporter activity
XSP_002743	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XSP_002747	COG1187	pseudouridine synthase activity
XSP_002748	COG5001	Diguanylate cyclase
XSP_002748	COG5002	protein histidine kinase activity
XSP_002760	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XSP_002768	COG0667	Aldo Keto reductase
XSP_002769	COG2814	Major facilitator Superfamily
XSP_002770	COG0583	DNA-binding transcription factor activity
XSP_002772	COG2207	Transcriptional regulator
XSP_002776	COG1309	transcriptional regulator
XSP_002781	COG0735	belongs to the Fur family
XSP_002782	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XSP_002787	COG4452	Inner membrane protein CreD
XSP_002791	COG2205	protein histidine kinase activity
XSP_002792	COG0745	RESPONSE REGULATOR receiver
XSP_002793	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XSP_002795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XSP_002797	COG2198	Histidine kinase
XSP_002797	COG0643	Histidine kinase
XSP_002798	COG0840	transmembrane signaling receptor activity
XSP_002799	COG0835	chemotaxis
XSP_002800	COG2200	EAL domain
XSP_002800	COG2199	diguanylate cyclase activity
XSP_002800	COG2202	Pas domain
XSP_002801	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XSP_002803	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XSP_002804	COG3590	peptidase
XSP_002806	COG0588	phosphoglycerate mutase activity
XSP_002807	COG1515	deoxyribonuclease V activity
XSP_002808	COG1741	Belongs to the pirin family
XSP_002810	COG1741	Belongs to the pirin family
XSP_002811	COG1966	Carbon starvation protein
XSP_002812	COG2879	small protein
XSP_002813	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XSP_002819	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XSP_002820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XSP_002821	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XSP_002822	COG2080	2 iron, 2 sulfur cluster binding
XSP_002824	COG3706	GGDEF domain
XSP_002824	COG4251	negative regulation of phosphorylation
XSP_002824	COG5001	Diguanylate cyclase
XSP_002824	COG2203	Gaf domain
XSP_002825	COG0629	single-stranded DNA binding
XSP_002826	COG0142	geranyltranstransferase activity
XSP_002828	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XSP_002831	COG0527	aspartate kinase activity
XSP_002832	COG0384	phenazine biosynthesis protein PhzF
XSP_002833	COG0384	phenazine biosynthesis protein PhzF
XSP_002835	COG1764	response to oxidative stress
XSP_002837	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XSP_002838	COG1678	Uncharacterized ACR, COG1678
XSP_002839	COG0519	Catalyzes the synthesis of GMP from XMP
XSP_002845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XSP_002848	COG4942	peptidase
XSP_002852	COG0693	protein deglycase activity
XSP_002854	COG1959	2 iron, 2 sulfur cluster binding
XSP_002855	COG0719	Fe-S assembly protein
XSP_002856	COG0396	ATPase activity
XSP_002857	COG0719	Fe-S assembly protein
XSP_002858	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XSP_002860	COG2146	nitrite reductase [NAD(P)H] activity
XSP_002861	COG4774	siderophore transport
XSP_002862	COG3128	pkhd-type hydroxylase
XSP_002867	COG1477	protein flavinylation
XSP_002870	COG1555	photosystem II stabilization
XSP_002871	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XSP_002873	COG3178	'Phosphotransferase
XSP_002874	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XSP_002876	COG0628	permease
XSP_002880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XSP_002885	COG0271	Belongs to the BolA IbaG family
XSP_002887	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XSP_002889	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XSP_002890	COG1137	ATPase activity
XSP_002893	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XSP_002897	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XSP_002898	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XSP_002899	COG2239	Acts as a magnesium transporter
XSP_002901	COG1294	oxidase, subunit
XSP_002902	COG1271	oxidase subunit
XSP_002903	COG1113	amino acid transport
XSP_002906	COG2197	response regulator
XSP_002907	COG0531	amino acid
XSP_002917	COG2814	Major facilitator Superfamily
XSP_002918	COG0754	glutathionylspermidine amidase activity
XSP_002923	COG1842	Phage shock protein A
XSP_002926	COG0259	pyridoxamine-phosphate oxidase activity
XSP_002927	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XSP_002928	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XSP_002930	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XSP_002945	COG0477	Major facilitator Superfamily
XSP_002948	COG2353	YceI-like domain
XSP_002949	COG3038	cytochrome b561
XSP_002952	COG1760	l-serine dehydratase
XSP_002954	COG0527	aspartate kinase activity
XSP_002954	COG0460	homoserine dehydrogenase
XSP_002955	COG0626	cystathionine gamma-synthase activity
XSP_002956	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XSP_002957	COG0739	heme binding
XSP_002958	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XSP_002959	COG1272	protein, Hemolysin III
XSP_002960	COG2982	Protein involved in outer membrane biogenesis
XSP_002961	COG0516	GMP reductase activity
XSP_002961	COG0517	IMP dehydrogenase activity
XSP_002962	COG0463	Glycosyl transferase, family 2
XSP_002963	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XSP_002964	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XSP_002966	COG4771	TonB-dependent receptor
XSP_002967	COG1309	transcriptional regulator
XSP_002969	COG1960	acyl-CoA dehydrogenase activity
XSP_002975	COG0509	glycine decarboxylation via glycine cleavage system
XSP_002976	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XSP_002977	COG1742	UPF0060 membrane protein
XSP_002980	COG0494	nUDIX hydrolase
XSP_002982	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XSP_002983	COG0837	glucose binding
XSP_002986	COG3858	chitin binding
XSP_002986	COG1388	LysM domain
XSP_002987	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XSP_002989	COG1472	Belongs to the glycosyl hydrolase 3 family
XSP_002991	COG3537	Alpha-1,2-mannosidase
XSP_002997	COG1446	asparaginase
XSP_003000	COG2201	protein-glutamate methylesterase activity
XSP_003001	COG0643	Histidine kinase
XSP_003001	COG0784	Response regulator, receiver
XSP_003001	COG2198	Histidine kinase
XSP_003002	COG0840	transmembrane signaling receptor activity
XSP_003003	COG0835	chemotaxis
XSP_003006	COG0189	ligase activity
XSP_003008	COG1397	ADP-ribosylglycohydrolase
XSP_003010	COG1199	ATP-dependent helicase activity
XSP_003012	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XSP_003013	COG1215	transferase activity, transferring glycosyl groups
XSP_003015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XSP_003019	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XSP_003020	COG0535	radical SAM domain protein
XSP_003023	COG0837	glucose binding
XSP_003026	COG1643	Atp-dependent helicase
XSP_003027	COG0783	Belongs to the Dps family
XSP_003028	COG0514	ATP-dependent DNA helicase (RecQ)
XSP_003032	COG1187	pseudouridine synthase activity
XSP_003034	COG0840	transmembrane signaling receptor activity
XSP_003038	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XSP_003042	COG0667	Aldo Keto reductase
XSP_003043	COG0602	queuosine metabolic process
XSP_003045	COG2885	chlorophyll binding
XSP_003046	COG0823	Involved in the tonB-independent uptake of proteins
XSP_003048	COG0848	biopolymer transport protein
XSP_003050	COG0824	Thioesterase
XSP_003051	COG2255	four-way junction helicase activity
XSP_003061	COG0477	Major facilitator Superfamily
XSP_003066	COG0488	(ABC) transporter
XSP_003072	COG4651	solute:proton antiporter activity
XSP_003072	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XSP_003074	COG4772	TonB-dependent receptor
XSP_003076	COG4264	IucA IucC family
XSP_003077	COG2814	Major facilitator Superfamily
XSP_003078	COG4264	IucA IucC family
XSP_003079	COG0019	diaminopimelate decarboxylase activity
XSP_003082	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XSP_003084	COG4206	TonB-dependent receptor
XSP_003087	COG0542	response to heat
XSP_003088	COG1116	anion transmembrane transporter activity
XSP_003089	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XSP_003090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XSP_003091	COG0667	Aldo Keto reductase
XSP_003092	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XSP_003093	COG4771	TonB-dependent receptor
XSP_003104	COG3387	PFAM Glycoside hydrolase 15-related
XSP_003107	COG0840	transmembrane signaling receptor activity
XSP_003109	COG0564	pseudouridine synthase activity
XSP_003110	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XSP_003112	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XSP_003112	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XSP_003114	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XSP_003115	COG0045	succinate-CoA ligase (ADP-forming) activity
XSP_003119	COG4969	Belongs to the N-Me-Phe pilin family
XSP_003120	COG1459	type II secretion system
XSP_003121	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XSP_003125	COG0745	RESPONSE REGULATOR receiver
XSP_003127	COG0189	ligase activity
XSP_003132	COG0840	transmembrane signaling receptor activity
XSP_003135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XSP_003136	COG0471	metal ion transport
XSP_003141	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XSP_003142	COG0471	metal ion transport
XSP_003142	COG3273	potassium ion transport
XSP_003146	COG1970	mechanosensitive ion channel activity
XSP_003148	COG1609	Transcriptional regulator
XSP_003150	COG3250	beta-galactosidase activity
XSP_003151	COG4948	Mandelate Racemase Muconate Lactonizing
XSP_003153	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XSP_003156	COG0308	aminopeptidase N
XSP_003157	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XSP_003158	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XSP_003159	COG2895	sulfate adenylyltransferase (ATP) activity
XSP_003159	COG0529	Catalyzes the synthesis of activated sulfate
XSP_003161	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XSP_003162	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XSP_003163	COG0175	sulfate reduction
XSP_003167	COG2205	protein histidine kinase activity
XSP_003167	COG2198	Histidine kinase
XSP_003167	COG0784	Response regulator, receiver
XSP_003170	COG1648	precorrin-2 dehydrogenase activity
XSP_003170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XSP_003172	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XSP_003173	COG3588	fructose-bisphosphate aldolase
XSP_003174	COG0469	pyruvate kinase activity
XSP_003180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XSP_003183	COG3047	cAMP biosynthetic process
XSP_003185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XSP_003185	COG3453	Protein conserved in bacteria
XSP_003186	COG0725	ABC transporter, periplasmic molybdate-binding protein
XSP_003187	COG4149	molybdate abc transporter
XSP_003188	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XSP_003196	COG1376	ErfK ybiS ycfS ynhG family protein
XSP_003197	COG0739	heme binding
XSP_003198	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_003199	COG0583	DNA-binding transcription factor activity
XSP_003200	COG4773	Receptor
XSP_003201	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XSP_003202	COG1301	dicarboxylic acid transport
XSP_003209	COG0714	Associated with various cellular activities
XSP_003215	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XSP_003220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XSP_003222	COG2721	sulfolactate sulfo-lyase activity
XSP_003225	COG2271	Major facilitator Superfamily
XSP_003229	COG0583	DNA-binding transcription factor activity
XSP_003230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XSP_003233	COG1561	YicC-like family, N-terminal region
XSP_003234	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XSP_003237	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XSP_003240	COG0006	proline dipeptidase activity
XSP_003242	COG0006	proline dipeptidase activity
XSP_003247	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XSP_003251	COG2912	Transglutaminase-like superfamily
XSP_003252	COG1773	rubredoxin
XSP_003253	COG0352	thiamine-phosphate diphosphorylase activity
XSP_003256	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XSP_003258	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XSP_003259	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XSP_003265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XSP_003266	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XSP_003269	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_003271	COG0671	phosphoesterase, PA-phosphatase related
XSP_003272	COG3781	membrane
XSP_003274	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XSP_003275	COG0563	adenylate kinase activity
XSP_003279	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XSP_003281	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XSP_003285	COG3710	Transcriptional regulator
XSP_003286	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XSP_003287	COG0823	Involved in the tonB-independent uptake of proteins
XSP_003287	COG4946	Tricorn protease homolog
XSP_003287	COG1506	peptidase
XSP_003288	COG0840	transmembrane signaling receptor activity
XSP_003289	COG0405	Gamma-glutamyltransferase
XSP_003290	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XSP_003294	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XSP_003296	COG0066	3-isopropylmalate dehydratase activity
XSP_003297	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XSP_003301	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XSP_003302	COG1538	Outer membrane efflux protein
XSP_003303	COG1519	Transferase
XSP_003304	COG1560	Kdo2-lipid A biosynthetic process
XSP_003309	COG0281	malic enzyme
XSP_003309	COG0280	phosphate acetyltransferase
XSP_003312	COG4191	Histidine kinase
XSP_003315	COG0667	Aldo Keto reductase
XSP_003316	COG2197	response regulator
XSP_003318	COG0642	Histidine kinase
XSP_003321	COG2851	Citrate transporter
XSP_003322	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_003323	COG1609	Transcriptional regulator
XSP_003324	COG2211	Major facilitator Superfamily
XSP_003334	COG4773	Receptor
XSP_003335	COG0726	polysaccharide deacetylase
XSP_003336	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XSP_003339	COG3964	amidohydrolase
XSP_003340	COG0402	S-adenosylhomocysteine deaminase activity
XSP_003345	COG1307	EDD domain protein, DegV family
XSP_003347	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XSP_003348	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XSP_003353	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XSP_003353	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XSP_003356	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XSP_003358	COG0488	(ABC) transporter
XSP_003359	COG0242	peptide deformylase activity
XSP_003372	COG2188	Transcriptional regulator
XSP_003374	COG1450	Type ii and iii secretion system protein
XSP_003377	COG3166	PFAM Fimbrial assembly family protein
XSP_003378	COG3156	type II secretion system protein K
XSP_003379	COG4795	General secretion pathway protein
XSP_003380	COG2165	general secretion pathway protein
XSP_003381	COG4970	Tfp pilus assembly protein FimT
XSP_003382	COG2165	general secretion pathway protein
XSP_003383	COG1459	type II secretion system
XSP_003384	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XSP_003385	COG1404	Belongs to the peptidase S8 family
XSP_003386	COG5295	Hep Hag repeat protein
XSP_003387	COG1404	Belongs to the peptidase S8 family
XSP_003388	COG5295	Hep Hag repeat protein
XSP_003389	COG0047	phosphoribosylformylglycinamidine synthase activity
XSP_003389	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XSP_003390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XSP_003391	COG4974	Belongs to the 'phage' integrase family
XSP_003393	COG0795	lipopolysaccharide-transporting ATPase activity
XSP_003402	COG1183	phosphatidylcholine synthase activity
XSP_003404	COG0442	prolyl-tRNA aminoacylation
XSP_003407	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XSP_003408	COG1127	ABC transporter
XSP_003409	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XSP_003409	COG3218	ABC-type transport auxiliary lipoprotein component
XSP_003415	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XSP_003416	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XSP_003417	COG0662	Cupin 2, conserved barrel domain protein
XSP_003417	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XSP_003422	COG2086	electron transfer activity
XSP_003424	COG0626	cystathionine gamma-synthase activity
XSP_003428	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XSP_003436	COG0625	glutathione transferase activity
XSP_003439	COG0513	Belongs to the DEAD box helicase family
XSP_003441	COG4771	TonB-dependent receptor
XSP_003442	COG0720	synthase
XSP_003444	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XSP_003445	COG1956	GAF domain-containing protein
XSP_003447	COG2819	hydrolase of the alpha beta superfamily
XSP_003449	COG0546	phosphoglycolate phosphatase activity
XSP_003450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XSP_003453	COG0339	signal peptide processing
XSP_003460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XSP_003461	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XSP_003462	COG1136	(ABC) transporter
XSP_003463	COG0577	efflux transmembrane transporter activity
XSP_003468	COG4191	Histidine kinase
XSP_003470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XSP_003477	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XSP_003478	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XSP_003480	COG0356	it plays a direct role in the translocation of protons across the membrane
XSP_003484	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XSP_003486	COG0508	dehydrogenase complex catalyzes the overall conversion of
XSP_003493	COG2011	ABC-type metal ion transport system permease component
XSP_003494	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XSP_003495	COG0697	spore germination
XSP_003496	COG1666	GTP binding
XSP_003502	COG1187	pseudouridine synthase activity
XSP_003507	COG2205	protein histidine kinase activity
XSP_003511	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XSP_003512	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XSP_003522	COG0842	Transport permease protein
XSP_003523	COG1131	(ABC) transporter
XSP_003524	COG0025	NhaP-type Na H and K H
XSP_003526	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XSP_003527	COG1573	uracil-dna glycosylase
XSP_003529	COG3384	dioxygenase
XSP_003531	COG0583	DNA-binding transcription factor activity
XSP_003533	COG0667	Aldo Keto reductase
XSP_003535	COG3590	peptidase
XSP_003538	COG0531	amino acid
XSP_003541	COG2972	Histidine kinase
XSP_003544	COG3685	Protein conserved in bacteria
XSP_003545	COG3546	catalase activity
XSP_003550	COG2204	response regulator
XSP_003552	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_003554	COG1063	alcohol dehydrogenase
XSP_003566	COG1131	(ABC) transporter
XSP_003570	COG0840	transmembrane signaling receptor activity
XSP_003577	COG0659	secondary active sulfate transmembrane transporter activity
XSP_003578	COG0038	chloride channel
XSP_003579	COG0024	Methionine aminopeptidase
XSP_003582	COG1309	transcriptional regulator
XSP_003584	COG1902	pentaerythritol trinitrate reductase activity
XSP_003585	COG1309	transcriptional regulator
XSP_003591	COG1846	Transcriptional regulator
XSP_003600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XSP_003601	COG1490	D-aminoacyl-tRNA deacylase activity
XSP_003603	COG1247	-acetyltransferase
XSP_003604	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XSP_003611	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XSP_003611	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XSP_003613	COG0242	peptide deformylase activity
XSP_003614	COG1652	LysM domain
XSP_003615	COG0758	DNA mediated transformation
XSP_003619	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XSP_003619	COG1754	DNA topoisomerase type I activity
XSP_003620	COG0009	L-threonylcarbamoyladenylate synthase
XSP_003623	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_003625	COG0616	signal peptide processing
XSP_003626	COG0534	Mate efflux family protein
XSP_003629	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XSP_003630	COG0625	glutathione transferase activity
XSP_003633	COG1252	NADH dehydrogenase
XSP_003634	COG2860	membrane
XSP_003635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XSP_003636	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XSP_003637	COG2201	protein-glutamate methylesterase activity
XSP_003638	COG2177	Part of the ABC transporter FtsEX involved in
XSP_003639	COG2884	Cell division ATP-binding protein ftsE
XSP_003641	COG3118	belongs to the thioredoxin family
XSP_003642	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XSP_003643	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XSP_003647	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XSP_003647	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XSP_003648	COG1473	amidohydrolase
XSP_003650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XSP_003652	COG5383	Protein conserved in bacteria
XSP_003660	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XSP_003663	COG3023	N-Acetylmuramoyl-L-alanine amidase
XSP_003665	COG4948	Mandelate Racemase Muconate Lactonizing
XSP_003667	COG0531	amino acid
XSP_003670	COG2133	pyrroloquinoline quinone binding
XSP_003672	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XSP_003675	COG1610	YqeY-like protein
XSP_003676	COG1295	ribonuclease BN
XSP_003677	COG0358	DNA primase activity
XSP_003680	COG0109	protoheme IX farnesyltransferase activity
XSP_003686	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XSP_003689	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XSP_003698	COG0739	heme binding
XSP_003699	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XSP_003701	COG2211	Major facilitator Superfamily
XSP_003702	COG0708	Exodeoxyribonuclease III
XSP_003705	COG1192	Involved in chromosome partitioning
XSP_003706	COG1475	DNA binding
XSP_003710	COG0463	Glycosyl transferase, family 2
XSP_003715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XSP_003717	COG0018	arginyl-trna synthetase
XSP_003720	COG4221	oxidoreductase activity
XSP_003721	COG2755	lipolytic protein G-D-S-L family
XSP_003721	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XSP_003723	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XSP_003725	COG1166	arginine decarboxylase activity
XSP_003726	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XSP_003731	COG2960	long-chain fatty acid transporting porin activity
XSP_003732	COG0606	chelatase, subunit chli
XSP_003735	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XSP_003746	COG1090	epimerase
XSP_003747	COG0745	RESPONSE REGULATOR receiver
XSP_003748	COG0642	Histidine kinase
XSP_003752	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XSP_003756	COG0628	permease
XSP_003757	COG1011	Hydrolase
XSP_003758	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XSP_003762	COG2197	response regulator
XSP_003763	COG4585	Histidine kinase
XSP_003764	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XSP_003765	COG1136	(ABC) transporter
XSP_003770	COG0697	spore germination
XSP_003774	COG0180	Tryptophanyl-tRNA synthetase
XSP_003775	COG3237	CsbD-like
XSP_003783	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XSP_003786	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XSP_003787	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XSP_003787	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XSP_003792	COG2205	protein histidine kinase activity
XSP_003793	COG0745	RESPONSE REGULATOR receiver
XSP_003795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XSP_003800	COG1199	ATP-dependent helicase activity
XSP_003818	COG0625	glutathione transferase activity
XSP_003825	COG4555	ABC transporter
XSP_003827	COG1476	TRANSCRIPTIONal
XSP_003846	COG1131	(ABC) transporter
XSP_003847	COG0842	Transport permease protein
XSP_003848	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XSP_003850	COG1607	acyl-coa hydrolase
XSP_003853	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XSP_003854	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XSP_003856	COG1042	CoA-binding domain protein
XSP_003856	COG0045	succinate-CoA ligase (ADP-forming) activity
XSP_003856	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XSP_003859	COG4771	TonB-dependent receptor
XSP_003859	COG1629	transport
XSP_003860	COG2239	Acts as a magnesium transporter
XSP_003862	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XSP_003863	COG3387	PFAM Glycoside hydrolase 15-related
XSP_003866	COG3100	YcgL domain-containing protein
XSP_003867	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XSP_003872	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_003878	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XSP_003881	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XSP_003896	COG0210	DNA helicase
XSP_003898	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XSP_003900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XSP_003902	COG2159	amidohydrolase
XSP_003906	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XSP_003910	COG0357	Ribosomal RNA small subunit methyltransferase G
XSP_003912	COG3540	Alkaline phosphatase
XSP_003914	COG2091	lysine biosynthetic process via aminoadipic acid
XSP_003920	COG1940	carbohydrate kinase activity
XSP_003924	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XSP_003927	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XSP_003932	COG3507	Belongs to the glycosyl hydrolase 43 family
XSP_003936	COG1028	Short-chain dehydrogenase reductase Sdr
XSP_003937	COG0179	Fumarylacetoacetate (FAA) hydrolase
XSP_003938	COG4948	Mandelate Racemase Muconate Lactonizing
XSP_003939	COG3254	rhamnose metabolic process
XSP_003940	COG0738	Major facilitator superfamily
XSP_003941	COG1414	Transcriptional regulator
XSP_003942	COG1971	Probably functions as a manganese efflux pump
XSP_003943	COG1971	Probably functions as a manganese efflux pump
XSP_003944	COG2205	protein histidine kinase activity
XSP_003945	COG3459	Glycosyltransferase 36 associated
XSP_003946	COG2211	Major facilitator Superfamily
XSP_003947	COG3265	gluconokinase activity
XSP_003948	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XSP_003952	COG2911	Protein conserved in bacteria
XSP_003953	COG0729	surface antigen
XSP_003954	COG4771	TonB-dependent receptor
XSP_003955	COG0457	Tetratricopeptide repeat
XSP_003959	COG0519	Catalyzes the synthesis of GMP from XMP
XSP_003959	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XSP_003961	COG0805	protein transport
XSP_003962	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XSP_003963	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XSP_003965	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XSP_003968	COG2974	May be involved in recombination
XSP_003969	COG0037	tRNA processing
XSP_003970	COG2115	Belongs to the xylose isomerase family
XSP_003972	COG3661	Belongs to the glycosyl hydrolase 67 family
XSP_003974	COG4948	Mandelate Racemase Muconate Lactonizing
XSP_003976	COG1472	Belongs to the glycosyl hydrolase 3 family
XSP_003977	COG0246	Mannitol dehydrogenase
XSP_003981	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XSP_003982	COG1620	l-lactate permease
XSP_003987	COG3386	PFAM SMP-30 Gluconolaconase
XSP_003989	COG3250	beta-galactosidase activity
XSP_003990	COG1904	glucuronate isomerase
XSP_003991	COG3693	PFAM glycoside hydrolase, family 10
XSP_003994	COG2211	Major facilitator Superfamily
XSP_004000	COG2937	Belongs to the GPAT DAPAT family
XSP_004006	COG0284	orotidine-5'-phosphate decarboxylase activity
XSP_004007	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XSP_004008	COG3132	Protein of unknown function, DUF480
XSP_004012	COG0210	DNA helicase
XSP_004013	COG1435	thymidine kinase activity
XSP_004015	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XSP_004017	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XSP_004023	COG3135	benzoate transporter
XSP_004030	COG0676	glucose-6-phosphate 1-epimerase activity
XSP_004033	COG0730	response to heat
XSP_004038	COG0302	gtp cyclohydrolase
XSP_004041	COG1566	PFAM secretion protein HlyD family protein
XSP_004043	COG1289	transmembrane transporter activity
XSP_004044	COG0477	Major facilitator Superfamily
XSP_004047	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XSP_004051	COG4691	Plasmid stability protein
XSP_004052	COG1487	ribonuclease activity
XSP_004059	COG0564	pseudouridine synthase activity
XSP_004070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XSP_004071	COG1074	ATP-dependent DNA helicase activity
XSP_004072	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XSP_004079	COG1127	ABC transporter
XSP_004080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XSP_004081	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XSP_004084	COG2853	Lipoprotein
XSP_004086	COG0386	Belongs to the glutathione peroxidase family
XSP_004088	COG1322	Protein conserved in bacteria
XSP_004089	COG0604	alcohol dehydrogenase
XSP_004092	COG0625	glutathione transferase activity
XSP_004094	COG0531	amino acid
XSP_004095	COG3537	Alpha-1,2-mannosidase
XSP_004097	COG3706	GGDEF domain
XSP_004098	COG3835	regulator
XSP_004099	COG1929	Belongs to the glycerate kinase type-1 family
XSP_004100	COG2271	Major facilitator Superfamily
XSP_004108	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XSP_004109	COG0861	Integral membrane protein TerC family
XSP_004111	COG0584	glycerophosphoryl diester phosphodiesterase
XSP_004114	COG0671	phosphoesterase, PA-phosphatase related
XSP_004116	COG0706	membrane insertase activity
XSP_004154	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XSP_004156	COG2948	multi-organism process