locus-tag	class	description
HEP73_00002	COG0592	DNA-directed DNA polymerase activity
HEP73_00004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP73_00005	COG0187	DNA topoisomerase II activity
HEP73_00006	COG1266	CAAX protease self-immunity
HEP73_00007	COG0501	Belongs to the peptidase M48B family
HEP73_00017	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP73_00023	COG1280	lysine exporter protein (LysE YggA)
HEP73_00027	COG4772	TonB-dependent receptor
HEP73_00030	COG3284	Transcriptional regulator
HEP73_00031	COG1012	belongs to the aldehyde dehydrogenase family
HEP73_00040	COG0277	FAD linked oxidase domain protein
HEP73_00042	COG2186	Transcriptional regulator
HEP73_00045	COG4585	Histidine kinase
HEP73_00046	COG2197	response regulator
HEP73_00053	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP73_00053	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP73_00056	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP73_00075	COG4771	TonB-dependent receptor
HEP73_00085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HEP73_00088	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP73_00089	COG1609	Transcriptional regulator
HEP73_00091	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_00093	COG2755	lipolytic protein G-D-S-L family
HEP73_00095	COG3186	Phenylalanine-4-hydroxylase
HEP73_00096	COG1522	sequence-specific DNA binding
HEP73_00099	COG1752	Esterase of the alpha-beta hydrolase superfamily
HEP73_00101	COG1595	DNA-templated transcription, initiation
HEP73_00103	COG3220	belongs to the UPF0276 family
HEP73_00114	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HEP73_00121	COG1929	Belongs to the glycerate kinase type-1 family
HEP73_00123	COG2814	Major facilitator Superfamily
HEP73_00127	COG0531	amino acid
HEP73_00128	COG4566	intracellular signal transduction
HEP73_00129	COG4191	Histidine kinase
HEP73_00133	COG0625	glutathione transferase activity
HEP73_00134	COG1322	Protein conserved in bacteria
HEP73_00136	COG0386	Belongs to the glutathione peroxidase family
HEP73_00138	COG2853	Lipoprotein
HEP73_00141	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEP73_00142	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEP73_00143	COG1127	ABC transporter
HEP73_00150	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HEP73_00151	COG1074	ATP-dependent DNA helicase activity
HEP73_00153	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEP73_00159	COG0537	adenosine 5'-monophosphoramidase activity
HEP73_00170	COG0477	Major facilitator Superfamily
HEP73_00171	COG0302	gtp cyclohydrolase
HEP73_00176	COG0730	response to heat
HEP73_00180	COG2951	lytic endotransglycosylase activity
HEP73_00185	COG3135	benzoate transporter
HEP73_00191	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP73_00192	COG1803	Methylglyoxal synthase
HEP73_00193	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP73_00194	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP73_00195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP73_00197	COG0493	'glutamate synthase
HEP73_00198	COG0069	glutamate synthase activity
HEP73_00198	COG0070	glutamate synthase
HEP73_00198	COG0067	glutamate synthase
HEP73_00203	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_00209	COG1111	helicase
HEP73_00209	COG1205	dead DEAH box helicase
HEP73_00210	COG3549	Plasmid maintenance system killer
HEP73_00220	COG2271	Major facilitator Superfamily
HEP73_00222	COG0657	acetylesterase activity
HEP73_00233	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP73_00234	COG1192	Involved in chromosome partitioning
HEP73_00237	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP73_00238	COG2050	protein possibly involved in aromatic compounds catabolism
HEP73_00242	COG1881	PFAM PEBP family protein
HEP73_00244	COG0174	glutamine synthetase
HEP73_00245	COG0347	Belongs to the P(II) protein family
HEP73_00246	COG0004	ammonium transporteR
HEP73_00247	COG3852	Histidine kinase
HEP73_00248	COG2204	response regulator
HEP73_00249	COG2032	superoxide dismutase activity
HEP73_00250	COG2032	superoxide dismutase activity
HEP73_00252	COG0183	Belongs to the thiolase family
HEP73_00261	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP73_00265	COG0702	epimerase
HEP73_00266	COG0583	DNA-binding transcription factor activity
HEP73_00269	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HEP73_00271	COG0612	Peptidase, M16
HEP73_00273	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP73_00275	COG0596	Alpha beta hydrolase
HEP73_00277	COG0727	PFAM Uncharacterised protein family (UPF0153)
HEP73_00278	COG0318	PFAM AMP-dependent synthetase and ligase
HEP73_00281	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP73_00283	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP73_00289	COG0564	pseudouridine synthase activity
HEP73_00295	COG1595	DNA-templated transcription, initiation
HEP73_00296	COG1446	asparaginase
HEP73_00297	COG0339	signal peptide processing
HEP73_00298	COG0681	Belongs to the peptidase S26 family
HEP73_00303	COG0583	DNA-binding transcription factor activity
HEP73_00304	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HEP73_00305	COG2224	Isocitrate lyase
HEP73_00311	COG0659	secondary active sulfate transmembrane transporter activity
HEP73_00318	COG0583	DNA-binding transcription factor activity
HEP73_00319	COG1959	2 iron, 2 sulfur cluster binding
HEP73_00321	COG1690	Belongs to the RtcB family
HEP73_00324	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP73_00325	COG2130	NADP-dependent
HEP73_00328	COG1187	pseudouridine synthase activity
HEP73_00330	COG1643	Atp-dependent helicase
HEP73_00331	COG1643	Atp-dependent helicase
HEP73_00332	COG0084	hydrolase, TatD family'
HEP73_00352	COG0842	Transport permease protein
HEP73_00353	COG1131	(ABC) transporter
HEP73_00354	COG0543	2 iron, 2 sulfur cluster binding
HEP73_00354	COG0633	Ferredoxin
HEP73_00355	COG2207	Transcriptional regulator
HEP73_00355	COG0662	Cupin 2, conserved barrel domain protein
HEP73_00358	COG1476	TRANSCRIPTIONal
HEP73_00360	COG4555	ABC transporter
HEP73_00364	COG0625	glutathione transferase activity
HEP73_00371	COG0028	Belongs to the TPP enzyme family
HEP73_00376	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP73_00380	COG1199	ATP-dependent helicase activity
HEP73_00393	COG0628	permease
HEP73_00398	COG2133	pyrroloquinoline quinone binding
HEP73_00406	COG5463	Belongs to the UPF0441 family
HEP73_00407	COG0754	glutathionylspermidine amidase activity
HEP73_00409	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP73_00422	COG0714	Associated with various cellular activities
HEP73_00429	COG1522	sequence-specific DNA binding
HEP73_00430	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEP73_00433	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_00434	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP73_00439	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEP73_00447	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HEP73_00449	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP73_00452	COG2267	carboxylic ester hydrolase activity
HEP73_00453	COG0606	chelatase, subunit chli
HEP73_00454	COG2960	long-chain fatty acid transporting porin activity
HEP73_00459	COG1166	arginine decarboxylase activity
HEP73_00460	COG2755	lipolytic protein G-D-S-L family
HEP73_00460	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP73_00462	COG0583	DNA-binding transcription factor activity
HEP73_00466	COG4221	oxidoreductase activity
HEP73_00470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEP73_00474	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEP73_00476	COG2814	Major facilitator Superfamily
HEP73_00478	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HEP73_00479	COG0739	heme binding
HEP73_00480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEP73_00486	COG1064	alcohol dehydrogenase
HEP73_00487	COG2234	aminopeptidase activity
HEP73_00489	COG4942	peptidase
HEP73_00490	COG0793	Belongs to the peptidase S41A family
HEP73_00496	COG0531	amino acid
HEP73_00498	COG1486	melibiose metabolic process
HEP73_00501	COG1565	acr, cog1565
HEP73_00501	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEP73_00504	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HEP73_00505	COG1845	cytochrome c oxidase, subunit III
HEP73_00510	COG0109	protoheme IX farnesyltransferase activity
HEP73_00514	COG0358	DNA primase activity
HEP73_00515	COG1295	ribonuclease BN
HEP73_00516	COG1610	YqeY-like protein
HEP73_00519	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEP73_00520	COG2308	Evidence 4 Homologs of previously reported genes of
HEP73_00523	COG2133	pyrroloquinoline quinone binding
HEP73_00527	COG0531	amino acid
HEP73_00529	COG4948	Mandelate Racemase Muconate Lactonizing
HEP73_00531	COG4771	TonB-dependent receptor
HEP73_00532	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP73_00538	COG3409	Peptidoglycan-binding domain 1 protein
HEP73_00538	COG3501	Rhs element vgr protein
HEP73_00540	COG0477	Major facilitator Superfamily
HEP73_00541	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HEP73_00548	COG5383	Protein conserved in bacteria
HEP73_00552	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_00555	COG1652	LysM domain
HEP73_00560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HEP73_00561	COG3118	belongs to the thioredoxin family
HEP73_00563	COG2884	Cell division ATP-binding protein ftsE
HEP73_00564	COG2177	Part of the ABC transporter FtsEX involved in
HEP73_00565	COG2201	protein-glutamate methylesterase activity
HEP73_00566	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEP73_00567	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP73_00568	COG2860	membrane
HEP73_00569	COG1252	NADH dehydrogenase
HEP73_00571	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HEP73_00573	COG0534	Mate efflux family protein
HEP73_00574	COG0616	signal peptide processing
HEP73_00576	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_00579	COG0009	L-threonylcarbamoyladenylate synthase
HEP73_00580	COG1754	DNA topoisomerase type I activity
HEP73_00580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEP73_00581	COG1714	RDD family
HEP73_00584	COG0758	DNA mediated transformation
HEP73_00585	COG1652	LysM domain
HEP73_00586	COG0242	peptide deformylase activity
HEP73_00588	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP73_00588	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HEP73_00589	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP73_00591	COG3307	-O-antigen
HEP73_00592	COG0463	Glycosyl transferase, family 2
HEP73_00596	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP73_00599	COG1490	D-aminoacyl-tRNA deacylase activity
HEP73_00600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP73_00603	COG1609	Transcriptional regulator
HEP73_00604	COG3537	Alpha-1,2-mannosidase
HEP73_00605	COG1733	regulation of RNA biosynthetic process
HEP73_00607	COG0366	Alpha amylase catalytic
HEP73_00608	COG0366	Alpha amylase catalytic
HEP73_00609	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP73_00617	COG2207	Transcriptional regulator
HEP73_00624	COG0300	oxidoreductase activity
HEP73_00627	COG3550	peptidyl-serine autophosphorylation
HEP73_00633	COG1309	transcriptional regulator
HEP73_00634	COG0604	alcohol dehydrogenase
HEP73_00637	COG0024	Methionine aminopeptidase
HEP73_00643	COG4773	Receptor
HEP73_00644	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_00645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP73_00646	COG1538	Outer membrane efflux protein
HEP73_00648	COG2207	Transcriptional regulator
HEP73_00649	COG0024	Methionine aminopeptidase
HEP73_00651	COG1309	transcriptional regulator
HEP73_00655	COG2124	cytochrome p450
HEP73_00655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP73_00656	COG1309	transcriptional regulator
HEP73_00658	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP73_00659	COG2271	Major facilitator Superfamily
HEP73_00664	COG0745	RESPONSE REGULATOR receiver
HEP73_00665	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HEP73_00665	COG3266	domain, Protein
HEP73_00665	COG4932	domain protein
HEP73_00669	COG0840	transmembrane signaling receptor activity
HEP73_00673	COG3546	catalase activity
HEP73_00674	COG3685	Protein conserved in bacteria
HEP73_00675	COG3685	Protein conserved in bacteria
HEP73_00676	COG0588	phosphoglycerate mutase activity
HEP73_00677	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEP73_00678	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_00680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP73_00687	COG0028	Belongs to the TPP enzyme family
HEP73_00688	COG4191	Histidine kinase
HEP73_00689	COG2204	response regulator
HEP73_00693	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP73_00693	COG1648	precorrin-2 dehydrogenase activity
HEP73_00695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEP73_00695	COG1116	anion transmembrane transporter activity
HEP73_00701	COG2223	nitrite transmembrane transporter activity
HEP73_00702	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP73_00703	COG2146	nitrite reductase [NAD(P)H] activity
HEP73_00704	COG0243	molybdopterin cofactor binding
HEP73_00710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP73_00712	COG0297	glycogen (starch) synthase activity
HEP73_00714	COG0745	RESPONSE REGULATOR receiver
HEP73_00716	COG1335	isochorismatase
HEP73_00721	COG0181	hydroxymethylbilane synthase activity
HEP73_00724	COG1733	regulation of RNA biosynthetic process
HEP73_00727	COG1505	serine-type exopeptidase activity
HEP73_00728	COG0436	Aminotransferase
HEP73_00730	COG2832	Protein of unknown function (DUF454)
HEP73_00737	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HEP73_00743	COG2226	methyltransferase
HEP73_00744	COG0308	aminopeptidase N
HEP73_00745	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP73_00745	COG0596	Alpha beta hydrolase
HEP73_00751	COG2010	Cytochrome c
HEP73_00753	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEP73_00755	COG3284	Transcriptional regulator
HEP73_00758	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP73_00759	COG1077	Cell shape determining protein MreB Mrl
HEP73_00760	COG1792	Involved in formation and maintenance of cell shape
HEP73_00762	COG0768	penicillin binding
HEP73_00763	COG0772	Belongs to the SEDS family
HEP73_00765	COG2951	lytic endotransglycosylase activity
HEP73_00767	COG1686	Belongs to the peptidase S11 family
HEP73_00770	COG0321	lipoyl(octanoyl) transferase activity
HEP73_00771	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEP73_00777	COG1056	cytidyltransferase-related domain
HEP73_00777	COG1051	belongs to the nudix hydrolase family
HEP73_00783	COG1090	epimerase
HEP73_00785	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP73_00786	COG0673	inositol 2-dehydrogenase activity
HEP73_00787	COG2823	Periplasmic or secreted lipoprotein
HEP73_00789	COG2202	Pas domain
HEP73_00789	COG2205	protein histidine kinase activity
HEP73_00790	COG0784	Response regulator, receiver
HEP73_00791	COG4191	Histidine kinase
HEP73_00793	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEP73_00794	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_00797	COG4305	rare lipoprotein A
HEP73_00801	COG3250	beta-galactosidase activity
HEP73_00804	COG2188	Transcriptional regulator
HEP73_00806	COG1609	Transcriptional regulator
HEP73_00807	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP73_00808	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEP73_00809	COG3001	Fructosamine kinase
HEP73_00814	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP73_00817	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HEP73_00819	COG2207	Transcriptional regulator
HEP73_00828	COG2205	protein histidine kinase activity
HEP73_00832	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEP73_00833	COG3791	Glutathione-dependent formaldehyde-activating
HEP73_00835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP73_00837	COG0697	spore germination
HEP73_00839	COG1307	EDD domain protein, DegV family
HEP73_00843	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP73_00846	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEP73_00864	COG0436	Aminotransferase
HEP73_00865	COG1162	GTPase activity
HEP73_00870	COG2211	Major facilitator Superfamily
HEP73_00872	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_00873	COG2851	Citrate transporter
HEP73_00876	COG0642	Histidine kinase
HEP73_00878	COG2205	protein histidine kinase activity
HEP73_00878	COG2205	protein histidine kinase activity
HEP73_00878	COG3292	Two component regulator propeller
HEP73_00878	COG0745	RESPONSE REGULATOR receiver
HEP73_00878	COG3292	Two component regulator propeller
HEP73_00878	COG0745	RESPONSE REGULATOR receiver
HEP73_00881	COG4191	Histidine kinase
HEP73_00883	COG1301	dicarboxylic acid transport
HEP73_00884	COG0281	malic enzyme
HEP73_00884	COG0280	phosphate acetyltransferase
HEP73_00889	COG1560	Kdo2-lipid A biosynthetic process
HEP73_00890	COG1519	Transferase
HEP73_00891	COG1538	Outer membrane efflux protein
HEP73_00892	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP73_00895	COG0473	3-isopropylmalate dehydrogenase activity
HEP73_00896	COG0066	3-isopropylmalate dehydratase activity
HEP73_00899	COG4106	trans-aconitate 2-methyltransferase activity
HEP73_00900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP73_00904	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEP73_00906	COG2815	serine threonine protein kinase
HEP73_00906	COG0515	serine threonine protein kinase
HEP73_00907	COG0405	Gamma-glutamyltransferase
HEP73_00908	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HEP73_00909	COG0840	transmembrane signaling receptor activity
HEP73_00912	COG0823	Involved in the tonB-independent uptake of proteins
HEP73_00916	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HEP73_00918	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HEP73_00924	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEP73_00926	COG0671	phosphoesterase, PA-phosphatase related
HEP73_00928	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_00929	COG1940	carbohydrate kinase activity
HEP73_00930	COG0346	lactoylglutathione lyase activity
HEP73_00931	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP73_00932	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP73_00934	COG4206	TonB-dependent receptor
HEP73_00936	COG2010	Cytochrome c
HEP73_00938	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP73_00939	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HEP73_00940	COG2909	trisaccharide binding
HEP73_00941	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEP73_00944	COG1773	rubredoxin
HEP73_00949	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEP73_00954	COG3079	Belongs to the UPF0149 family
HEP73_00955	COG0006	proline dipeptidase activity
HEP73_00956	COG0006	proline dipeptidase activity
HEP73_00959	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEP73_00960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEP73_00961	COG0346	lactoylglutathione lyase activity
HEP73_00962	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HEP73_00963	COG1561	YicC-like family, N-terminal region
HEP73_00964	COG0194	GDP metabolic process
HEP73_00965	COG1758	RNA polymerase activity
HEP73_00966	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP73_00968	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEP73_00970	COG0254	rRNA binding
HEP73_00971	COG0372	Belongs to the citrate synthase family
HEP73_00974	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEP73_00980	COG0714	Associated with various cellular activities
HEP73_00986	COG1301	dicarboxylic acid transport
HEP73_00987	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEP73_00992	COG0739	heme binding
HEP73_00993	COG1376	ErfK ybiS ycfS ynhG family protein
HEP73_01001	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HEP73_01002	COG4149	molybdate abc transporter
HEP73_01003	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEP73_01005	COG0640	Transcriptional regulator
HEP73_01008	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP73_01009	COG3591	Belongs to the peptidase S1B family
HEP73_01015	COG3047	cAMP biosynthetic process
HEP73_01016	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEP73_01019	COG4221	oxidoreductase activity
HEP73_01020	COG4221	oxidoreductase activity
HEP73_01022	COG3321	synthase
HEP73_01022	COG0604	alcohol dehydrogenase
HEP73_01023	COG0840	transmembrane signaling receptor activity
HEP73_01028	COG0469	pyruvate kinase activity
HEP73_01029	COG3588	fructose-bisphosphate aldolase
HEP73_01031	COG2205	protein histidine kinase activity
HEP73_01034	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HEP73_01040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP73_01040	COG1648	precorrin-2 dehydrogenase activity
HEP73_01043	COG0784	Response regulator, receiver
HEP73_01043	COG2198	Histidine kinase
HEP73_01043	COG2205	protein histidine kinase activity
HEP73_01044	COG0431	NADPH-dependent FMN reductase
HEP73_01045	COG1393	Belongs to the ArsC family
HEP73_01050	COG0175	sulfate reduction
HEP73_01051	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP73_01052	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP73_01054	COG2895	sulfate adenylyltransferase (ATP) activity
HEP73_01054	COG0529	Catalyzes the synthesis of activated sulfate
HEP73_01056	COG0438	transferase activity, transferring glycosyl groups
HEP73_01060	COG1115	amino acid carrier protein
HEP73_01062	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP73_01064	COG1609	Transcriptional regulator
HEP73_01067	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP73_01070	COG3273	potassium ion transport
HEP73_01070	COG0471	metal ion transport
HEP73_01072	COG2022	thiamine diphosphate biosynthetic process
HEP73_01077	COG3511	phospholipase C
HEP73_01079	COG0189	ligase activity
HEP73_01081	COG0745	RESPONSE REGULATOR receiver
HEP73_01084	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HEP73_01091	COG1215	transferase activity, transferring glycosyl groups
HEP73_01097	COG4993	Dehydrogenase
HEP73_01098	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEP73_01098	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP73_01100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEP73_01102	COG1174	glycine betaine transport
HEP73_01103	COG1125	glycine betaine transport
HEP73_01105	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP73_01106	COG0564	pseudouridine synthase activity
HEP73_01110	COG0840	transmembrane signaling receptor activity
HEP73_01111	COG4993	Dehydrogenase
HEP73_01113	COG3387	PFAM Glycoside hydrolase 15-related
HEP73_01117	COG0454	-acetyltransferase
HEP73_01122	COG0542	response to heat
HEP73_01127	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_01128	COG1733	regulation of RNA biosynthetic process
HEP73_01130	COG2223	nitrite transmembrane transporter activity
HEP73_01132	COG0019	diaminopimelate decarboxylase activity
HEP73_01133	COG4264	IucA IucC family
HEP73_01134	COG2814	Major facilitator Superfamily
HEP73_01135	COG4264	IucA IucC family
HEP73_01137	COG4772	TonB-dependent receptor
HEP73_01139	COG4651	solute:proton antiporter activity
HEP73_01139	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP73_01150	COG0488	(ABC) transporter
HEP73_01157	COG2755	lipolytic protein G-D-S-L family
HEP73_01157	COG0657	acetylesterase activity
HEP73_01159	COG4774	siderophore transport
HEP73_01168	COG0217	transcriptional regulatory protein
HEP73_01170	COG0632	four-way junction helicase activity
HEP73_01173	COG0824	Thioesterase
HEP73_01175	COG0848	biopolymer transport protein
HEP73_01177	COG0823	Involved in the tonB-independent uptake of proteins
HEP73_01178	COG2885	chlorophyll binding
HEP73_01180	COG0602	queuosine metabolic process
HEP73_01181	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HEP73_01188	COG0514	ATP-dependent DNA helicase (RecQ)
HEP73_01190	COG0783	Belongs to the Dps family
HEP73_01191	COG1643	Atp-dependent helicase
HEP73_01198	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP73_01200	COG1216	Glycosyl transferase, family 2
HEP73_01201	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP73_01203	COG1199	ATP-dependent helicase activity
HEP73_01205	COG1397	ADP-ribosylglycohydrolase
HEP73_01208	COG0189	ligase activity
HEP73_01211	COG0835	chemotaxis
HEP73_01212	COG0840	transmembrane signaling receptor activity
HEP73_01213	COG2198	Histidine kinase
HEP73_01213	COG0784	Response regulator, receiver
HEP73_01213	COG0643	Histidine kinase
HEP73_01214	COG2201	protein-glutamate methylesterase activity
HEP73_01220	COG2801	Transposase and inactivated derivatives
HEP73_01223	COG1446	asparaginase
HEP73_01236	COG3279	Response regulator of the LytR AlgR family
HEP73_01237	COG3275	phosphorelay sensor kinase activity
HEP73_01238	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
HEP73_01242	COG0583	DNA-binding transcription factor activity
HEP73_01246	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP73_01263	COG3537	Alpha-1,2-mannosidase
HEP73_01265	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP73_01267	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HEP73_01268	COG3858	chitin binding
HEP73_01268	COG1388	LysM domain
HEP73_01271	COG0837	glucose binding
HEP73_01273	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HEP73_01275	COG0494	nUDIX hydrolase
HEP73_01277	COG3956	TIGRFAM MazG family protein
HEP73_01280	COG0330	HflC and HflK could
HEP73_01287	COG0697	spore germination
HEP73_01292	COG1960	acyl-CoA dehydrogenase activity
HEP73_01299	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HEP73_01300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP73_01301	COG0463	Glycosyl transferase, family 2
HEP73_01302	COG0517	IMP dehydrogenase activity
HEP73_01303	COG2982	Protein involved in outer membrane biogenesis
HEP73_01304	COG1272	protein, Hemolysin III
HEP73_01305	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HEP73_01307	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP73_01308	COG0626	cystathionine gamma-synthase activity
HEP73_01309	COG0527	aspartate kinase activity
HEP73_01309	COG0460	homoserine dehydrogenase
HEP73_01312	COG1760	l-serine dehydratase
HEP73_01315	COG3038	cytochrome b561
HEP73_01319	COG0477	Major facilitator Superfamily
HEP73_01320	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HEP73_01323	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEP73_01338	COG3706	GGDEF domain
HEP73_01346	COG0519	Catalyzes the synthesis of GMP from XMP
HEP73_01349	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEP73_01358	COG1113	amino acid transport
HEP73_01362	COG2239	Acts as a magnesium transporter
HEP73_01363	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP73_01364	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP73_01366	COG1660	Displays ATPase and GTPase activities
HEP73_01368	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP73_01371	COG1137	ATPase activity
HEP73_01374	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HEP73_01381	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEP73_01386	COG0628	permease
HEP73_01388	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP73_01389	COG3178	'Phosphotransferase
HEP73_01392	COG1555	photosystem II stabilization
HEP73_01396	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP73_01397	COG1477	protein flavinylation
HEP73_01402	COG4774	siderophore transport
HEP73_01403	COG2146	nitrite reductase [NAD(P)H] activity
HEP73_01405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP73_01406	COG0719	Fe-S assembly protein
HEP73_01407	COG0396	ATPase activity
HEP73_01408	COG0719	Fe-S assembly protein
HEP73_01411	COG0693	protein deglycase activity
HEP73_01414	COG0739	heme binding
HEP73_01417	COG1764	response to oxidative stress
HEP73_01419	COG0384	phenazine biosynthesis protein PhzF
HEP73_01420	COG0527	aspartate kinase activity
HEP73_01425	COG0142	geranyltranstransferase activity
HEP73_01426	COG0629	single-stranded DNA binding
HEP73_01431	COG2010	Cytochrome c
HEP73_01433	COG0673	inositol 2-dehydrogenase activity
HEP73_01434	COG2211	Major facilitator Superfamily
HEP73_01436	COG1609	Transcriptional regulator
HEP73_01441	COG3104	oligopeptide transport
HEP73_01442	COG1297	OPT oligopeptide transporter protein
HEP73_01443	COG1506	peptidase
HEP73_01443	COG0823	Involved in the tonB-independent uptake of proteins
HEP73_01447	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP73_01448	COG2879	small protein
HEP73_01449	COG1966	Carbon starvation protein
HEP73_01450	COG1741	Belongs to the pirin family
HEP73_01452	COG1741	Belongs to the pirin family
HEP73_01454	COG1515	deoxyribonuclease V activity
HEP73_01458	COG2211	Major facilitator Superfamily
HEP73_01460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP73_01463	COG3706	GGDEF domain
HEP73_01463	COG4251	negative regulation of phosphorylation
HEP73_01463	COG5001	Diguanylate cyclase
HEP73_01463	COG2203	Gaf domain
HEP73_01464	COG0835	chemotaxis
HEP73_01465	COG0840	transmembrane signaling receptor activity
HEP73_01467	COG0840	transmembrane signaling receptor activity
HEP73_01468	COG2198	Histidine kinase
HEP73_01468	COG0643	Histidine kinase
HEP73_01470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HEP73_01473	COG3878	Protein conserved in bacteria
HEP73_01474	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HEP73_01476	COG0642	Histidine kinase
HEP73_01477	COG3111	PFAM Bacterial OB fold (BOF) protein
HEP73_01478	COG0745	RESPONSE REGULATOR receiver
HEP73_01479	COG2205	protein histidine kinase activity
HEP73_01481	COG4452	Inner membrane protein CreD
HEP73_01486	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP73_01487	COG0735	belongs to the Fur family
HEP73_01496	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP73_01498	COG1309	transcriptional regulator
HEP73_01501	COG3214	Protein conserved in bacteria
HEP73_01505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP73_01506	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEP73_01507	COG2080	2 iron, 2 sulfur cluster binding
HEP73_01514	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEP73_01527	COG1187	pseudouridine synthase activity
HEP73_01532	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP73_01533	COG3795	YCII-related domain
HEP73_01537	COG4941	Belongs to the sigma-70 factor family
HEP73_01542	COG1132	(ABC) transporter
HEP73_01549	COG0583	DNA-binding transcription factor activity
HEP73_01558	COG1981	membrane
HEP73_01560	COG0825	malonyl-CoA metabolic process
HEP73_01563	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP73_01564	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP73_01568	COG0750	zinc metalloprotease
HEP73_01569	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HEP73_01570	COG0575	Belongs to the CDS family
HEP73_01571	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEP73_01573	COG0528	UMP kinase activity
HEP73_01575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEP73_01583	COG0024	Methionine aminopeptidase
HEP73_01586	COG1393	Belongs to the ArsC family
HEP73_01587	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP73_01588	COG0367	asparagine synthase
HEP73_01598	COG1566	PFAM secretion protein HlyD family protein
HEP73_01599	COG2814	Major facilitator Superfamily
HEP73_01607	COG0557	exoribonuclease II activity
HEP73_01609	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP73_01612	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP73_01616	COG0704	Plays a role in the regulation of phosphate uptake
HEP73_01618	COG0581	inorganic phosphate transmembrane transporter activity
HEP73_01621	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP73_01625	COG0659	secondary active sulfate transmembrane transporter activity
HEP73_01626	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HEP73_01628	COG1024	Enoyl-CoA hydratase
HEP73_01637	COG0488	(ABC) transporter
HEP73_01640	COG0784	Response regulator, receiver
HEP73_01640	COG2205	protein histidine kinase activity
HEP73_01640	COG5002	protein histidine kinase activity
HEP73_01641	COG2733	membrane
HEP73_01651	COG0686	Belongs to the AlaDH PNT family
HEP73_01652	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP73_01653	COG1396	sequence-specific DNA binding
HEP73_01653	COG1917	Cupin 2, conserved barrel domain protein
HEP73_01654	COG1012	belongs to the aldehyde dehydrogenase family
HEP73_01658	COG0243	molybdopterin cofactor binding
HEP73_01660	COG0477	Major facilitator Superfamily
HEP73_01662	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP73_01663	COG0174	glutamine synthetase
HEP73_01664	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HEP73_01665	COG0174	glutamine synthetase
HEP73_01667	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP73_01668	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP73_01670	COG0501	Belongs to the peptidase M48B family
HEP73_01675	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HEP73_01688	COG3842	ATPase activity
HEP73_01689	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEP73_01690	COG1177	transmembrane transport
HEP73_01691	COG1012	belongs to the aldehyde dehydrogenase family
HEP73_01692	COG0598	Magnesium transport protein CorA
HEP73_01694	COG4535	Mg2 and Co2 transporter CorC
HEP73_01700	COG1702	phosphate starvation-inducible protein PhoH
HEP73_01704	COG0625	glutathione transferase activity
HEP73_01706	COG0741	lytic transglycosylase activity
HEP73_01707	COG0723	plastoquinol--plastocyanin reductase activity
HEP73_01708	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP73_01710	COG2857	Cytochrome c1
HEP73_01711	COG0625	glutathione transferase activity
HEP73_01712	COG2969	positive regulation of protein catabolic process
HEP73_01720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEP73_01721	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_01722	COG2095	MarC family integral membrane protein
HEP73_01725	COG1611	Belongs to the LOG family
HEP73_01734	COG0556	nucleotide-excision repair
HEP73_01741	COG2948	multi-organism process
HEP73_01750	COG0366	Alpha amylase catalytic
HEP73_01753	COG1082	Xylose isomerase domain protein TIM barrel
HEP73_01762	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEP73_01764	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEP73_01765	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEP73_01766	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP73_01766	COG0072	phenylalanine-tRNA ligase activity
HEP73_01775	COG0438	transferase activity, transferring glycosyl groups
HEP73_01778	COG0438	transferase activity, transferring glycosyl groups
HEP73_01783	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEP73_01785	COG1960	acyl-CoA dehydrogenase activity
HEP73_01789	COG1846	Transcriptional regulator
HEP73_01795	COG1570	exodeoxyribonuclease VII activity
HEP73_01797	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEP73_01797	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HEP73_01798	COG0802	atpase or kinase
HEP73_01799	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEP73_01800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HEP73_01804	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_01808	COG2081	HI0933 family
HEP73_01809	COG4681	YaeQ
HEP73_01810	COG0564	pseudouridine synthase activity
HEP73_01812	COG0625	glutathione transferase activity
HEP73_01813	COG0657	acetylesterase activity
HEP73_01820	COG0513	Belongs to the DEAD box helicase family
HEP73_01821	COG0488	(ABC) transporter
HEP73_01824	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HEP73_01825	COG2207	Transcriptional regulator
HEP73_01828	COG2197	response regulator
HEP73_01837	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP73_01838	COG1846	Transcriptional regulator
HEP73_01839	COG0339	signal peptide processing
HEP73_01840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP73_01841	COG0386	Belongs to the glutathione peroxidase family
HEP73_01847	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP73_01856	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HEP73_01860	COG0084	hydrolase, TatD family'
HEP73_01863	COG1960	acyl-CoA dehydrogenase activity
HEP73_01866	COG0305	Participates in initiation and elongation during chromosome replication
HEP73_01869	COG2204	response regulator
HEP73_01871	COG0415	Belongs to the DNA photolyase family
HEP73_01874	COG0583	DNA-binding transcription factor activity
HEP73_01877	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_01881	COG3706	GGDEF domain
HEP73_01882	COG0583	DNA-binding transcription factor activity
HEP73_01886	COG1404	Belongs to the peptidase S8 family
HEP73_01887	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HEP73_01890	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP73_01891	COG0735	belongs to the Fur family
HEP73_01892	COG0497	DNA recombination
HEP73_01893	COG1420	regulation of RNA biosynthetic process
HEP73_01894	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP73_01895	COG0443	Heat shock 70 kDa protein
HEP73_01896	COG0484	heat shock protein binding
HEP73_01899	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HEP73_01900	COG1605	Chorismate mutase
HEP73_01900	COG0287	Prephenate dehydrogenase
HEP73_01902	COG1132	(ABC) transporter
HEP73_01912	COG2850	peptidyl-arginine hydroxylation
HEP73_01913	COG2885	chlorophyll binding
HEP73_01922	COG1131	(ABC) transporter
HEP73_01923	COG1725	Transcriptional regulator
HEP73_01925	COG0386	Belongs to the glutathione peroxidase family
HEP73_01928	COG2900	Belongs to the SlyX family
HEP73_01930	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP73_01930	COG2755	lipolytic protein G-D-S-L family
HEP73_01932	COG1410	methionine synthase
HEP73_01932	COG0646	methionine synthase
HEP73_01933	COG0646	methionine synthase
HEP73_01933	COG1410	methionine synthase
HEP73_01934	COG2226	methyltransferase
HEP73_01935	COG1960	acyl-CoA dehydrogenase activity
HEP73_01936	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP73_01937	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_01939	COG2902	Dehydrogenase
HEP73_01946	COG2925	Exonuclease
HEP73_01948	COG3844	kynureninase activity
HEP73_01951	COG0288	reversible hydration of carbon dioxide
HEP73_01966	COG0316	Belongs to the HesB IscA family
HEP73_01967	COG2977	Belongs to the P-Pant transferase superfamily
HEP73_01973	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP73_01975	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HEP73_01979	COG4993	Dehydrogenase
HEP73_01989	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HEP73_01995	COG4221	oxidoreductase activity
HEP73_02003	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HEP73_02004	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP73_02005	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HEP73_02006	COG1605	Chorismate mutase
HEP73_02006	COG0077	Prephenate dehydratase
HEP73_02011	COG0583	DNA-binding transcription factor activity
HEP73_02017	COG1530	ribonuclease E activity
HEP73_02019	COG3064	Membrane
HEP73_02020	COG0428	transporter
HEP73_02023	COG0316	Belongs to the HesB IscA family
HEP73_02023	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HEP73_02027	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_02031	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP73_02032	COG2957	Belongs to the agmatine deiminase family
HEP73_02035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HEP73_02036	COG0539	negative regulation of cytoplasmic translation
HEP73_02037	COG0776	regulation of translation
HEP73_02039	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HEP73_02040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEP73_02042	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEP73_02043	COG0183	Belongs to the thiolase family
HEP73_02044	COG1024	Enoyl-CoA hydratase
HEP73_02044	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP73_02047	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HEP73_02049	COG1426	Protein conserved in bacteria
HEP73_02051	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP73_02053	COG0746	molybdenum cofactor guanylyltransferase activity
HEP73_02055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEP73_02056	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP73_02056	COG0475	glutathione-regulated potassium exporter activity
HEP73_02059	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP73_02061	COG0519	Catalyzes the synthesis of GMP from XMP
HEP73_02061	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP73_02063	COG2801	Transposase and inactivated derivatives
HEP73_02066	COG0084	hydrolase, TatD family'
HEP73_02070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEP73_02076	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP73_02077	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP73_02078	COG4191	Histidine kinase
HEP73_02078	COG0784	Response regulator, receiver
HEP73_02080	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HEP73_02082	COG1914	H( )-stimulated, divalent metal cation uptake system
HEP73_02085	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HEP73_02086	COG0668	transmembrane transport
HEP73_02091	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_02092	COG1183	phosphatidylcholine synthase activity
HEP73_02094	COG3243	poly(R)-hydroxyalkanoic acid synthase
HEP73_02098	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP73_02098	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HEP73_02100	COG4191	Histidine kinase
HEP73_02100	COG0784	Response regulator, receiver
HEP73_02101	COG2183	response to ionizing radiation
HEP73_02102	COG0784	Response regulator, receiver
HEP73_02102	COG2205	protein histidine kinase activity
HEP73_02141	COG0305	Participates in initiation and elongation during chromosome replication
HEP73_02195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_02199	COG5000	phosphorelay sensor kinase activity
HEP73_02199	COG5002	protein histidine kinase activity
HEP73_02201	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_02209	COG2197	response regulator
HEP73_02210	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_02212	COG4585	Histidine kinase
HEP73_02215	COG0714	Associated with various cellular activities
HEP73_02217	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HEP73_02221	COG0577	efflux transmembrane transporter activity
HEP73_02221	COG1136	(ABC) transporter
HEP73_02231	COG1132	(ABC) transporter
HEP73_02235	COG0438	transferase activity, transferring glycosyl groups
HEP73_02236	COG0297	glycogen (starch) synthase activity
HEP73_02240	COG2226	methyltransferase
HEP73_02244	COG2244	polysaccharide biosynthetic process
HEP73_02250	COG3038	cytochrome b561
HEP73_02254	COG1595	DNA-templated transcription, initiation
HEP73_02261	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP73_02269	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP73_02270	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HEP73_02271	COG1230	cation diffusion facilitator family transporter
HEP73_02274	COG1674	ftsk spoiiie
HEP73_02275	COG0492	ferredoxin-NADP+ reductase activity
HEP73_02279	COG0542	response to heat
HEP73_02283	COG0482	sulfurtransferase activity
HEP73_02284	COG2915	High frequency lysogenization protein hflD homolog
HEP73_02287	COG1116	anion transmembrane transporter activity
HEP73_02296	COG0784	Response regulator, receiver
HEP73_02296	COG0835	chemotaxis
HEP73_02298	COG1558	bacterial-type flagellum-dependent cell motility
HEP73_02299	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HEP73_02300	COG1749	Flagellar hook protein flgE
HEP73_02303	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HEP73_02306	COG1256	bacterial-type flagellum assembly
HEP73_02306	COG4786	Flagellar basal body rod
HEP73_02307	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HEP73_02309	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HEP73_02313	COG2197	response regulator
HEP73_02315	COG2201	protein-glutamate methylesterase activity
HEP73_02319	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP73_02320	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_02331	COG1677	Flagellar hook-basal body complex protein FliE
HEP73_02341	COG3190	flagellar
HEP73_02343	COG1987	bacterial-type flagellum assembly
HEP73_02344	COG1684	flagellar biosynthetic protein fliR
HEP73_02354	COG0784	Response regulator, receiver
HEP73_02354	COG0643	Histidine kinase
HEP73_02354	COG2198	Histidine kinase
HEP73_02355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HEP73_02356	COG1360	Flagellar Motor Protein
HEP73_02357	COG1192	Involved in chromosome partitioning
HEP73_02360	COG0745	RESPONSE REGULATOR receiver
HEP73_02362	COG0840	transmembrane signaling receptor activity
HEP73_02363	COG0840	transmembrane signaling receptor activity
HEP73_02364	COG0840	transmembrane signaling receptor activity
HEP73_02366	COG0840	transmembrane signaling receptor activity
HEP73_02367	COG0840	transmembrane signaling receptor activity
HEP73_02368	COG0840	transmembrane signaling receptor activity
HEP73_02369	COG0840	transmembrane signaling receptor activity
HEP73_02371	COG0840	transmembrane signaling receptor activity
HEP73_02372	COG0840	transmembrane signaling receptor activity
HEP73_02374	COG0835	chemotaxis
HEP73_02376	COG0840	transmembrane signaling receptor activity
HEP73_02390	COG0318	PFAM AMP-dependent synthetase and ligase
HEP73_02391	COG1024	Enoyl-CoA hydratase
HEP73_02392	COG2198	Histidine kinase
HEP73_02392	COG0784	Response regulator, receiver
HEP73_02392	COG2205	protein histidine kinase activity
HEP73_02395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEP73_02396	COG3279	Response regulator of the LytR AlgR family
HEP73_02397	COG4676	Protein conserved in bacteria
HEP73_02400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP73_02401	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEP73_02403	COG0505	Belongs to the CarA family
HEP73_02405	COG2258	MOSC domain
HEP73_02406	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP73_02413	COG1024	Enoyl-CoA hydratase
HEP73_02417	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEP73_02421	COG0277	FAD linked oxidase domain protein
HEP73_02422	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEP73_02425	COG0531	amino acid
HEP73_02426	COG0531	amino acid
HEP73_02427	COG0235	Class ii aldolase
HEP73_02428	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HEP73_02429	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HEP73_02432	COG0140	phosphoribosyl-ATP diphosphatase activity
HEP73_02432	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEP73_02435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEP73_02438	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEP73_02439	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HEP73_02442	COG0124	histidyl-tRNA synthetase
HEP73_02443	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP73_02445	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEP73_02446	COG0083	homoserine kinase activity
HEP73_02447	COG0460	homoserine dehydrogenase
HEP73_02447	COG0527	aspartate kinase activity
HEP73_02450	COG1012	belongs to the aldehyde dehydrogenase family
HEP73_02455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEP73_02458	COG1794	racemase activity, acting on amino acids and derivatives
HEP73_02459	COG0671	phosphoesterase, PA-phosphatase related
HEP73_02462	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HEP73_02469	COG0166	Belongs to the GPI family
HEP73_02472	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HEP73_02473	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEP73_02474	COG0617	tRNA 3'-terminal CCA addition
HEP73_02476	COG0477	Major facilitator Superfamily
HEP73_02477	COG2115	Belongs to the xylose isomerase family
HEP73_02478	COG1070	Carbohydrate kinase
HEP73_02480	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP73_02487	COG0800	Aldolase
HEP73_02490	COG3734	2-keto-3-deoxy-galactonokinase
HEP73_02491	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HEP73_02493	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP73_02495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEP73_02496	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HEP73_02499	COG0352	thiamine-phosphate diphosphorylase activity
HEP73_02499	COG0351	phosphomethylpyrimidine kinase
HEP73_02504	COG0583	DNA-binding transcription factor activity
HEP73_02505	COG1741	Belongs to the pirin family
HEP73_02508	COG0194	GDP metabolic process
HEP73_02511	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HEP73_02512	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEP73_02513	COG2137	regulation of response to DNA damage stimulus
HEP73_02514	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HEP73_02515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP73_02516	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP73_02517	COG1546	Belongs to the CinA family
HEP73_02518	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEP73_02520	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HEP73_02521	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEP73_02522	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP73_02523	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HEP73_02524	COG1534	Rna-binding protein
HEP73_02527	COG1238	metal cluster binding
HEP73_02529	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HEP73_02532	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HEP73_02533	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HEP73_02534	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HEP73_02538	COG0504	CTP synthase activity
HEP73_02545	COG0306	phosphate transporter
HEP73_02547	COG1253	flavin adenine dinucleotide binding
HEP73_02550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP73_02557	COG0069	glutamate synthase activity
HEP73_02558	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HEP73_02561	COG1609	Transcriptional regulator
HEP73_02562	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP73_02562	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP73_02563	COG1105	Belongs to the carbohydrate kinase PfkB family
HEP73_02564	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP73_02564	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP73_02571	COG0577	efflux transmembrane transporter activity
HEP73_02571	COG1136	(ABC) transporter
HEP73_02580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP73_02582	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEP73_02583	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HEP73_02585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEP73_02587	COG0348	domain, Protein
HEP73_02596	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP73_02599	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP73_02602	COG1663	tetraacyldisaccharide 4'-kinase activity
HEP73_02603	COG1132	(ABC) transporter
HEP73_02605	COG0811	peptide transport
HEP73_02606	COG0658	competence protein
HEP73_02606	COG2333	competence protein COMEC
HEP73_02609	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEP73_02614	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HEP73_02617	COG3842	ATPase activity
HEP73_02618	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEP73_02621	COG0129	dihydroxy-acid dehydratase activity
HEP73_02622	COG0800	Aldolase
HEP73_02624	COG0395	ABC-type sugar transport system, permease component
HEP73_02632	COG2350	Protein conserved in bacteria
HEP73_02633	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HEP73_02634	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HEP73_02635	COG1187	pseudouridine synthase activity
HEP73_02640	COG0436	Aminotransferase
HEP73_02641	COG4133	protoheme IX ABC transporter activity
HEP73_02645	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HEP73_02651	COG1278	Cold shock
HEP73_02652	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HEP73_02653	COG4988	ABC transporter
HEP73_02655	COG1294	oxidase, subunit
HEP73_02660	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEP73_02666	COG0165	Argininosuccinate lyase
HEP73_02667	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEP73_02669	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEP73_02670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP73_02671	COG0137	argininosuccinate synthase activity
HEP73_02672	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEP73_02674	COG0215	cysteine-tRNA ligase activity
HEP73_02675	COG2166	iron-sulfur cluster assembly
HEP73_02682	COG4993	Dehydrogenase
HEP73_02682	COG2010	Cytochrome c
HEP73_02689	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP73_02695	COG4303	Ethanolamine ammonia lyase large subunit
HEP73_02696	COG4302	ethanolamine ammonia-lyase activity
HEP73_02697	COG4677	pectinesterase activity
HEP73_02701	COG0402	S-adenosylhomocysteine deaminase activity
HEP73_02702	COG3548	integral membrane protein
HEP73_02704	COG1509	lysine 2,3-aminomutase activity
HEP73_02712	COG1862	Preprotein translocase
HEP73_02715	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEP73_02717	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP73_02719	COG2755	lipolytic protein G-D-S-L family
HEP73_02719	COG0657	acetylesterase activity
HEP73_02720	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEP73_02724	COG3291	Pkd domain containing protein
HEP73_02725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP73_02726	COG0405	Gamma-glutamyltransferase
HEP73_02727	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEP73_02730	COG0742	ribosomal rna small subunit methyltransferase
HEP73_02735	COG3345	alpha-galactosidase
HEP73_02737	COG4771	TonB-dependent receptor
HEP73_02739	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP73_02746	COG0531	amino acid
HEP73_02749	COG0006	proline dipeptidase activity
HEP73_02751	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP73_02754	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP73_02755	COG3938	Belongs to the proline racemase family
HEP73_02757	COG0552	protein localization to endoplasmic reticulum
HEP73_02761	COG2304	oxidoreductase activity
HEP73_02768	COG0835	chemotaxis
HEP73_02769	COG3290	protein histidine kinase activity
HEP73_02769	COG0840	transmembrane signaling receptor activity
HEP73_02770	COG1201	RNA secondary structure unwinding
HEP73_02772	COG3300	MHYT domain
HEP73_02772	COG5001	Diguanylate cyclase
HEP73_02773	COG1185	polyribonucleotide nucleotidyltransferase activity
HEP73_02778	COG0195	Participates in both transcription termination and antitermination
HEP73_02781	COG1007	ATP synthesis coupled electron transport
HEP73_02788	COG1034	ATP synthesis coupled electron transport
HEP73_02789	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEP73_02790	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HEP73_02791	COG0649	NAD binding
HEP73_02792	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP73_02794	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP73_02797	COG0149	triose-phosphate isomerase activity
HEP73_02798	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_02801	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HEP73_02811	COG0101	tRNA pseudouridine synthase activity
HEP73_02813	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEP73_02816	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP73_02818	COG0688	phosphatidylethanolamine metabolic process
HEP73_02819	COG0741	lytic transglycosylase activity
HEP73_02820	COG0433	COG0433 Predicted ATPase
HEP73_02821	COG0494	nUDIX hydrolase
HEP73_02824	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP73_02825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEP73_02830	COG0717	Belongs to the dCTP deaminase family
HEP73_02831	COG0489	protein tyrosine kinase activity
HEP73_02833	COG4771	TonB-dependent receptor
HEP73_02835	COG3590	peptidase
HEP73_02837	COG0705	Rhomboid family
HEP73_02842	COG2311	Membrane
HEP73_02843	COG1047	Peptidyl-prolyl cis-trans
HEP73_02844	COG0791	NLP P60 protein
HEP73_02845	COG0791	NLP P60 protein
HEP73_02846	COG1607	acyl-coa hydrolase
HEP73_02847	COG4106	trans-aconitate 2-methyltransferase activity
HEP73_02848	COG1301	dicarboxylic acid transport
HEP73_02849	COG1785	Belongs to the alkaline phosphatase family
HEP73_02851	COG0037	tRNA processing
HEP73_02852	COG1722	exodeoxyribonuclease VII activity
HEP73_02853	COG0142	geranyltranstransferase activity
HEP73_02855	COG4104	PAAR repeat-containing protein
HEP73_02862	COG0312	modulator of DNA gyrase
HEP73_02864	COG0312	modulator of DNA gyrase
HEP73_02868	COG2968	Membrane
HEP73_02871	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HEP73_02874	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEP73_02877	COG0495	leucyl-tRNA aminoacylation
HEP73_02879	COG3118	belongs to the thioredoxin family
HEP73_02883	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HEP73_02885	COG2040	homocysteine
HEP73_02887	COG0346	lactoylglutathione lyase activity
HEP73_02888	COG1131	(ABC) transporter
HEP73_02891	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP73_02891	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP73_02893	COG2878	Part of a membrane complex involved in electron transport
HEP73_02896	COG1595	DNA-templated transcription, initiation
HEP73_02901	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP73_02906	COG0251	oxidation-reduction process
HEP73_02908	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP73_02908	COG0392	lysyltransferase activity
HEP73_02916	COG2814	Major facilitator Superfamily
HEP73_02917	COG1902	pentaerythritol trinitrate reductase activity
HEP73_02918	COG0583	DNA-binding transcription factor activity
HEP73_02921	COG2824	Alkylphosphonate utilization operon protein PhnA
HEP73_02923	COG1047	Peptidyl-prolyl cis-trans
HEP73_02924	COG1077	Cell shape determining protein MreB Mrl
HEP73_02931	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HEP73_02933	COG1451	nucleotide metabolic process
HEP73_02937	COG2205	protein histidine kinase activity
HEP73_02939	COG2186	Transcriptional regulator
HEP73_02940	COG3250	beta-galactosidase activity
HEP73_02952	COG1703	isobutyryl-CoA mutase activity
HEP73_02952	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP73_02952	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP73_02957	COG0183	Belongs to the thiolase family
HEP73_02959	COG0443	Heat shock 70 kDa protein
HEP73_02965	COG1960	acyl-CoA dehydrogenase activity
HEP73_02966	COG1793	dna ligase
HEP73_02966	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEP73_02967	COG1793	dna ligase
HEP73_02967	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEP73_02968	COG1201	RNA secondary structure unwinding
HEP73_02970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP73_02971	COG1278	Cold shock
HEP73_02972	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEP73_02973	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HEP73_02974	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP73_02976	COG2954	triphosphatase activity
HEP73_02978	COG0745	RESPONSE REGULATOR receiver
HEP73_02979	COG1381	Involved in DNA repair and RecF pathway recombination
HEP73_02980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEP73_02983	COG0681	Belongs to the peptidase S26 family
HEP73_02984	COG0481	GTPase activity
HEP73_02985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP73_02988	COG1024	Enoyl-CoA hydratase
HEP73_02988	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP73_02993	COG2124	cytochrome p450
HEP73_02994	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_02995	COG2855	membrane
HEP73_02998	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HEP73_02999	COG3250	beta-galactosidase activity
HEP73_03000	COG3540	Alkaline phosphatase
HEP73_03005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HEP73_03008	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HEP73_03012	COG0534	Mate efflux family protein
HEP73_03013	COG0335	large ribosomal subunit rRNA binding
HEP73_03014	COG0336	Belongs to the RNA methyltransferase TrmD family
HEP73_03015	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HEP73_03016	COG0228	four-way junction DNA binding
HEP73_03018	COG2070	2-Nitropropane dioxygenase
HEP73_03019	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HEP73_03024	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP73_03028	COG0475	glutathione-regulated potassium exporter activity
HEP73_03032	COG0625	glutathione transferase activity
HEP73_03033	COG1082	Xylose isomerase domain protein TIM barrel
HEP73_03035	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP73_03036	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP73_03037	COG1129	ABC transporter
HEP73_03038	COG1879	ABC-type sugar transport system periplasmic component
HEP73_03039	COG1012	belongs to the aldehyde dehydrogenase family
HEP73_03042	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_03043	COG0129	dihydroxy-acid dehydratase activity
HEP73_03050	COG3152	Membrane
HEP73_03056	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_03056	COG0604	alcohol dehydrogenase
HEP73_03056	COG3321	synthase
HEP73_03059	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HEP73_03060	COG1845	cytochrome c oxidase, subunit III
HEP73_03061	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP73_03063	COG2964	Protein conserved in bacteria
HEP73_03066	COG4771	TonB-dependent receptor
HEP73_03071	COG0251	oxidation-reduction process
HEP73_03078	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HEP73_03081	COG0196	riboflavin kinase activity
HEP73_03082	COG0728	peptidoglycan biosynthetic process
HEP73_03084	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEP73_03085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HEP73_03086	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HEP73_03087	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP73_03088	COG0824	Thioesterase
HEP73_03090	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP73_03090	COG1024	Enoyl-CoA hydratase
HEP73_03091	COG1946	Acyl-CoA thioesterase
HEP73_03094	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HEP73_03097	COG0840	transmembrane signaling receptor activity
HEP73_03101	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HEP73_03105	COG1073	alpha beta
HEP73_03111	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HEP73_03116	COG4585	Histidine kinase
HEP73_03119	COG0850	regulation of cytokinetic process
HEP73_03120	COG2894	cell division
HEP73_03121	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HEP73_03123	COG2205	protein histidine kinase activity
HEP73_03124	COG0745	RESPONSE REGULATOR receiver
HEP73_03126	COG2194	sulfuric ester hydrolase activity
HEP73_03130	COG2814	Major facilitator Superfamily
HEP73_03131	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP73_03131	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP73_03133	COG2203	Gaf domain
HEP73_03133	COG5001	Diguanylate cyclase
HEP73_03133	COG4251	negative regulation of phosphorylation
HEP73_03133	COG3706	GGDEF domain
HEP73_03134	COG0753	catalase activity
HEP73_03140	COG1063	alcohol dehydrogenase
HEP73_03142	COG3459	Glycosyltransferase 36 associated
HEP73_03143	COG2186	Transcriptional regulator
HEP73_03147	COG2271	Major facilitator Superfamily
HEP73_03148	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_03155	COG1064	alcohol dehydrogenase
HEP73_03159	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_03162	COG0492	ferredoxin-NADP+ reductase activity
HEP73_03170	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_03171	COG3387	PFAM Glycoside hydrolase 15-related
HEP73_03173	COG3275	phosphorelay sensor kinase activity
HEP73_03181	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HEP73_03192	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEP73_03194	COG0330	HflC and HflK could
HEP73_03195	COG0330	HflC and HflK could
HEP73_03196	COG0604	alcohol dehydrogenase
HEP73_03200	COG0678	peroxiredoxin activity
HEP73_03202	COG4953	penicillin-binding protein 1C
HEP73_03203	COG1349	DNA-binding transcription factor activity
HEP73_03205	COG2223	nitrite transmembrane transporter activity
HEP73_03211	COG1136	(ABC) transporter
HEP73_03211	COG0577	efflux transmembrane transporter activity
HEP73_03215	COG2373	Large extracellular alpha-helical protein
HEP73_03225	COG0372	Belongs to the citrate synthase family
HEP73_03229	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP73_03238	COG2161	toxin-antitoxin pair type II binding
HEP73_03239	COG4115	mRNA cleavage
HEP73_03243	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEP73_03244	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEP73_03245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEP73_03247	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP73_03248	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_03249	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HEP73_03250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP73_03252	COG1399	metal-binding, possibly nucleic acid-binding protein
HEP73_03257	COG0714	Associated with various cellular activities
HEP73_03261	COG0537	adenosine 5'-monophosphoramidase activity
HEP73_03266	COG0314	molybdopterin synthase activity
HEP73_03267	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HEP73_03268	COG0315	cyclic pyranopterin monophosphate synthase activity
HEP73_03270	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEP73_03271	COG1234	tRNA 3'-trailer cleavage
HEP73_03273	COG0859	PFAM glycosyl transferase family 9
HEP73_03277	COG0631	protein serine/threonine phosphatase activity
HEP73_03278	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP73_03281	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP73_03282	COG1388	LysM domain
HEP73_03282	COG3942	CHAP domain
HEP73_03289	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEP73_03291	COG0544	peptidyl-prolyl cis-trans isomerase activity
HEP73_03300	COG0473	3-isopropylmalate dehydrogenase activity
HEP73_03303	COG4783	chaperone-mediated protein folding
HEP73_03306	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HEP73_03307	COG0248	Ppx GppA phosphatase
HEP73_03308	COG0438	transferase activity, transferring glycosyl groups
HEP73_03310	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP73_03312	COG3291	Pkd domain containing protein
HEP73_03313	COG2833	Protein of unknown function (DUF455)
HEP73_03317	COG0285	dihydrofolate synthase activity
HEP73_03318	COG0588	phosphoglycerate mutase activity
HEP73_03322	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HEP73_03323	COG4208	sulfate ABC transporter
HEP73_03324	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HEP73_03325	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HEP73_03328	COG1187	pseudouridine synthase activity
HEP73_03331	COG2885	chlorophyll binding
HEP73_03332	COG0583	DNA-binding transcription factor activity
HEP73_03333	COG2814	Major facilitator Superfamily
HEP73_03335	COG0667	Aldo Keto reductase
HEP73_03337	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP73_03337	COG1902	pentaerythritol trinitrate reductase activity
HEP73_03346	COG0625	glutathione transferase activity
HEP73_03352	COG0039	L-malate dehydrogenase activity
HEP73_03354	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEP73_03355	COG1217	gtp-binding protein TYPA
HEP73_03357	COG0154	amidase activity
HEP73_03360	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HEP73_03362	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HEP73_03363	COG0203	ribosomal protein L17
HEP73_03365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEP73_03368	COG0201	protein transport
HEP73_03370	COG1841	ribosomal large subunit assembly
HEP73_03376	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEP73_03377	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEP73_03379	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEP73_03380	COG0255	Belongs to the universal ribosomal protein uL29 family
HEP73_03385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEP73_03386	COG0089	rRNA binding
HEP73_03387	COG0088	Forms part of the polypeptide exit tunnel
HEP73_03389	COG0051	transcription antitermination factor activity, RNA binding
HEP73_03390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP73_03391	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP73_03394	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEP73_03396	COG0222	ribosome binding
HEP73_03399	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEP73_03400	COG0250	Participates in transcription elongation, termination and antitermination
HEP73_03403	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP73_03407	COG0012	GTP binding
HEP73_03408	COG0193	aminoacyl-tRNA hydrolase activity
HEP73_03410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEP73_03412	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HEP73_03415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HEP73_03416	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEP73_03419	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEP73_03422	COG1254	Belongs to the acylphosphatase family
HEP73_03423	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP73_03424	COG1295	ribonuclease BN
HEP73_03428	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEP73_03429	COG1404	Belongs to the peptidase S8 family
HEP73_03430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEP73_03431	COG2151	metal-sulfur cluster biosynthetic enzyme
HEP73_03442	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP73_03442	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP73_03443	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_03444	COG0583	DNA-binding transcription factor activity
HEP73_03452	COG3634	alkyl hydroperoxide reductase activity
HEP73_03453	COG0583	DNA-binding transcription factor activity
HEP73_03455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP73_03456	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP73_03460	COG2197	response regulator
HEP73_03465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP73_03467	COG0697	spore germination
HEP73_03477	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP73_03478	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP73_03480	COG2096	Adenosyltransferase
HEP73_03483	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HEP73_03484	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HEP73_03485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HEP73_03486	COG2967	ApaG domain
HEP73_03487	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HEP73_03493	COG1704	LemA family
HEP73_03494	COG0861	Integral membrane protein TerC family
HEP73_03495	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HEP73_03497	COG0642	Histidine kinase
HEP73_03500	COG4181	ATPase activity
HEP73_03501	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HEP73_03505	COG4771	TonB-dependent receptor
HEP73_03507	COG0667	Aldo Keto reductase
HEP73_03508	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HEP73_03512	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEP73_03516	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP73_03527	COG1349	DNA-binding transcription factor activity
HEP73_03532	COG2222	sugar isomerase
HEP73_03534	COG3345	alpha-galactosidase
HEP73_03537	COG0366	Alpha amylase catalytic
HEP73_03538	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HEP73_03540	COG0494	nUDIX hydrolase
HEP73_03543	COG0739	heme binding
HEP73_03544	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HEP73_03545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEP73_03547	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HEP73_03548	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP73_03550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP73_03553	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HEP73_03556	COG3116	cell division
HEP73_03557	COG0275	rRNA processing
HEP73_03558	COG2001	Belongs to the MraZ family
HEP73_03562	COG0792	nuclease activity
HEP73_03563	COG1988	membrane-bound metal-dependent
HEP73_03564	COG0277	FAD linked oxidase domain protein
HEP73_03565	COG0745	RESPONSE REGULATOR receiver
HEP73_03566	COG2205	protein histidine kinase activity
HEP73_03568	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP73_03569	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEP73_03573	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HEP73_03574	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP73_03575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HEP73_03579	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP73_03579	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP73_03581	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HEP73_03585	COG0477	Major facilitator Superfamily
HEP73_03586	COG0488	(ABC) transporter
HEP73_03587	COG0242	peptide deformylase activity
HEP73_03589	COG1960	acyl-CoA dehydrogenase activity
HEP73_03591	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP73_03593	COG1696	Membrane protein involved in D-alanine export
HEP73_03597	COG1215	transferase activity, transferring glycosyl groups
HEP73_03599	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HEP73_03600	COG0457	Tetratricopeptide repeat
HEP73_03601	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HEP73_03602	COG1215	transferase activity, transferring glycosyl groups
HEP73_03603	COG1215	transferase activity, transferring glycosyl groups
HEP73_03615	COG2188	Transcriptional regulator
HEP73_03617	COG1450	Type ii and iii secretion system protein
HEP73_03620	COG3166	PFAM Fimbrial assembly family protein
HEP73_03621	COG3156	type II secretion system protein K
HEP73_03622	COG4795	General secretion pathway protein
HEP73_03623	COG2165	general secretion pathway protein
HEP73_03624	COG4970	Tfp pilus assembly protein FimT
HEP73_03625	COG2165	general secretion pathway protein
HEP73_03627	COG1459	type II secretion system
HEP73_03628	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEP73_03629	COG1404	Belongs to the peptidase S8 family
HEP73_03630	COG5295	Hep Hag repeat protein
HEP73_03631	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEP73_03631	COG0047	phosphoribosylformylglycinamidine synthase activity
HEP73_03632	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP73_03633	COG4974	Belongs to the 'phage' integrase family
HEP73_03638	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP73_03644	COG1183	phosphatidylcholine synthase activity
HEP73_03646	COG0442	prolyl-tRNA aminoacylation
HEP73_03649	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEP73_03650	COG1127	ABC transporter
HEP73_03651	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEP73_03651	COG3218	ABC-type transport auxiliary lipoprotein component
HEP73_03657	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HEP73_03658	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP73_03659	COG0662	Cupin 2, conserved barrel domain protein
HEP73_03659	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HEP73_03665	COG2086	electron transfer activity
HEP73_03668	COG0546	phosphoglycolate phosphatase activity
HEP73_03668	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEP73_03669	COG0277	FAD linked oxidase domain protein
HEP73_03670	COG0300	oxidoreductase activity
HEP73_03671	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP73_03675	COG0493	'glutamate synthase
HEP73_03680	COG1216	Glycosyl transferase, family 2
HEP73_03680	COG0438	transferase activity, transferring glycosyl groups
HEP73_03681	COG1216	Glycosyl transferase, family 2
HEP73_03681	COG0438	transferase activity, transferring glycosyl groups
HEP73_03682	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HEP73_03685	COG0626	cystathionine gamma-synthase activity
HEP73_03691	COG0625	glutathione transferase activity
HEP73_03693	COG0513	Belongs to the DEAD box helicase family
HEP73_03694	COG0720	synthase
HEP73_03696	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEP73_03697	COG1956	GAF domain-containing protein
HEP73_03699	COG4206	TonB-dependent receptor
HEP73_03700	COG0546	phosphoglycolate phosphatase activity
HEP73_03704	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEP73_03708	COG0339	signal peptide processing
HEP73_03709	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEP73_03711	COG2217	Heavy metal translocating P-type atpase
HEP73_03714	COG2132	Multicopper oxidase
HEP73_03719	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP73_03721	COG1136	(ABC) transporter
HEP73_03722	COG0577	efflux transmembrane transporter activity
HEP73_03723	COG0577	efflux transmembrane transporter activity
HEP73_03724	COG0577	efflux transmembrane transporter activity
HEP73_03725	COG0577	efflux transmembrane transporter activity
HEP73_03726	COG1136	(ABC) transporter
HEP73_03726	COG0577	efflux transmembrane transporter activity
HEP73_03727	COG1136	(ABC) transporter
HEP73_03727	COG0577	efflux transmembrane transporter activity
HEP73_03728	COG1136	(ABC) transporter
HEP73_03728	COG0577	efflux transmembrane transporter activity
HEP73_03729	COG0577	efflux transmembrane transporter activity
HEP73_03729	COG1136	(ABC) transporter
HEP73_03731	COG1136	(ABC) transporter
HEP73_03731	COG0577	efflux transmembrane transporter activity
HEP73_03734	COG4191	Histidine kinase
HEP73_03736	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEP73_03739	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HEP73_03742	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEP73_03744	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEP73_03746	COG0356	it plays a direct role in the translocation of protons across the membrane
HEP73_03750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP73_03751	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP73_03758	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEP73_03759	COG0697	spore germination
HEP73_03760	COG1666	GTP binding
HEP73_03762	COG1187	pseudouridine synthase activity
HEP73_03763	COG2813	Specifically methylates the guanine in position
HEP73_03767	COG2205	protein histidine kinase activity
HEP73_03767	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP73_03772	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP73_03784	COG0842	Transport permease protein
HEP73_03785	COG1131	(ABC) transporter
HEP73_03786	COG0025	NhaP-type Na H and K H
HEP73_03788	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HEP73_03789	COG1573	uracil-dna glycosylase
HEP73_03791	COG3384	dioxygenase
HEP73_03795	COG0667	Aldo Keto reductase
HEP73_03796	COG0667	Aldo Keto reductase
HEP73_03799	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP73_03800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP73_03801	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP73_03806	COG5001	Diguanylate cyclase
HEP73_03810	COG4106	trans-aconitate 2-methyltransferase activity
HEP73_03813	COG2076	Multidrug Resistance protein
HEP73_03815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HEP73_03822	COG3275	phosphorelay sensor kinase activity
HEP73_03827	COG0531	amino acid
HEP73_03831	COG5297	Belongs to the glycosyl hydrolase family 6
HEP73_03831	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP73_03832	COG0612	Peptidase, M16
HEP73_03837	COG0741	lytic transglycosylase activity
HEP73_03842	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HEP73_03843	COG2207	Transcriptional regulator
HEP73_03846	COG0598	Magnesium transport protein CorA
HEP73_03849	COG0697	spore germination
HEP73_03856	COG2409	Drug exporters of the RND superfamily
HEP73_03857	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP73_03859	COG5520	Belongs to the glycosyl hydrolase 30 family
HEP73_03891	COG0584	glycerophosphoryl diester phosphodiesterase
HEP73_03894	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HEP73_03898	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEP73_03903	COG1595	DNA-templated transcription, initiation
HEP73_03904	COG0459	protein refolding
HEP73_03906	COG2356	endonuclease I
HEP73_03907	COG1324	tolerance protein
HEP73_03909	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP73_03912	COG1733	regulation of RNA biosynthetic process
HEP73_03913	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HEP73_03914	COG0511	ligase activity, forming carbon-carbon bonds
HEP73_03916	COG0439	Biotin carboxylase
HEP73_03918	COG0300	oxidoreductase activity
HEP73_03921	COG2264	protein methyltransferase activity
HEP73_03925	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HEP73_03926	COG4589	Belongs to the CDS family
HEP73_03931	COG2453	phosphatase
HEP73_03931	COG0671	phosphoesterase, PA-phosphatase related
HEP73_03932	COG2267	carboxylic ester hydrolase activity
HEP73_03933	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP73_03934	COG0138	bifunctional purine biosynthesis protein purh
HEP73_03936	COG0151	Belongs to the GarS family
HEP73_03938	COG4771	TonB-dependent receptor
HEP73_03940	COG1289	transmembrane transporter activity
HEP73_03941	COG2814	Major facilitator Superfamily
HEP73_03950	COG2816	NAD+ diphosphatase activity
HEP73_03956	COG0784	Response regulator, receiver
HEP73_03956	COG5002	protein histidine kinase activity
HEP73_03956	COG2205	protein histidine kinase activity
HEP73_03964	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HEP73_03967	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HEP73_03968	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP73_03969	COG0730	response to heat
HEP73_03971	COG0134	indole-3-glycerol-phosphate synthase activity
HEP73_03973	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEP73_03979	COG1597	lipid kinase activity
HEP73_03982	COG0484	heat shock protein binding
HEP73_03988	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP73_03989	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEP73_03989	COG2111	Na H antiporter
HEP73_03990	COG1006	Multisubunit Na H antiporter MnhC subunit
HEP73_03991	COG0651	ATP synthesis coupled electron transport
HEP73_03993	COG2212	antiporter activity
HEP73_03994	COG1320	monovalent cation:proton antiporter activity
HEP73_03999	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HEP73_04003	COG3104	oligopeptide transport
HEP73_04004	COG3483	tryptophan 2,3-dioxygenase activity
HEP73_04006	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HEP73_04009	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP73_04011	COG3227	Zinc metalloprotease (Elastase)
HEP73_04012	COG0513	Belongs to the DEAD box helicase family
HEP73_04014	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_04016	COG0702	epimerase
HEP73_04017	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP73_04019	COG2354	Protein conserved in bacteria
HEP73_04022	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP73_04024	COG1196	nuclear chromosome segregation
HEP73_04024	COG3264	Mechanosensitive ion channel
HEP73_04025	COG3321	synthase
HEP73_04025	COG0604	alcohol dehydrogenase
HEP73_04025	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_04029	COG1595	DNA-templated transcription, initiation
HEP73_04033	COG1802	Transcriptional regulator
HEP73_04036	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HEP73_04044	COG1414	Transcriptional regulator
HEP73_04045	COG0738	Major facilitator superfamily
HEP73_04046	COG3254	rhamnose metabolic process
HEP73_04047	COG4948	Mandelate Racemase Muconate Lactonizing
HEP73_04048	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP73_04049	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_04057	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP73_04060	COG4807	Protein conserved in bacteria
HEP73_04066	COG0708	Exodeoxyribonuclease III
HEP73_04071	COG5507	3-demethylubiquinone-9 3-methyltransferase
HEP73_04072	COG4773	Receptor
HEP73_04078	COG3220	belongs to the UPF0276 family
HEP73_04091	COG1192	Involved in chromosome partitioning
HEP73_04095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP73_04101	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP73_04102	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP73_04105	COG0753	catalase activity
HEP73_04108	COG4773	Receptor
HEP73_04109	COG2197	response regulator
HEP73_04110	COG4585	Histidine kinase
HEP73_04112	COG1131	(ABC) transporter
HEP73_04113	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP73_04114	COG1136	(ABC) transporter
HEP73_04115	COG0577	efflux transmembrane transporter activity
HEP73_04118	COG2962	Rard protein
HEP73_04119	COG0697	spore germination
HEP73_04120	COG2133	pyrroloquinoline quinone binding
HEP73_04122	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_04123	COG0583	DNA-binding transcription factor activity
HEP73_04126	COG0180	Tryptophanyl-tRNA synthetase
HEP73_04128	COG3237	CsbD-like
HEP73_04134	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HEP73_04135	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HEP73_04135	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HEP73_04143	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEP73_04149	COG2084	Dehydrogenase
HEP73_04150	COG1902	pentaerythritol trinitrate reductase activity
HEP73_04155	COG1404	Belongs to the peptidase S8 family
HEP73_04156	COG2814	Major facilitator Superfamily
HEP73_04157	COG0583	DNA-binding transcription factor activity
HEP73_04161	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP73_04162	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP73_04168	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HEP73_04170	COG1764	response to oxidative stress
HEP73_04171	COG1846	Transcriptional regulator
HEP73_04172	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HEP73_04174	COG0697	spore germination
HEP73_04175	COG0523	cobalamin synthesis protein
HEP73_04178	COG3245	cytochrome
HEP73_04180	COG1960	acyl-CoA dehydrogenase activity
HEP73_04181	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP73_04193	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEP73_04194	COG3387	PFAM Glycoside hydrolase 15-related
HEP73_04195	COG0745	RESPONSE REGULATOR receiver
HEP73_04198	COG1404	Belongs to the peptidase S8 family
HEP73_04200	COG3100	YcgL domain-containing protein
HEP73_04201	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP73_04203	COG0463	Glycosyl transferase, family 2
HEP73_04208	COG1028	Short-chain dehydrogenase reductase Sdr
HEP73_04215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HEP73_04218	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP73_04223	COG1294	oxidase, subunit
HEP73_04224	COG1271	oxidase subunit
HEP73_04228	COG0408	coproporphyrinogen oxidase activity
HEP73_04230	COG2323	membrane
HEP73_04240	COG0515	serine threonine protein kinase
HEP73_04241	COG0631	protein serine/threonine phosphatase activity
HEP73_04252	COG0515	serine threonine protein kinase
HEP73_04252	COG2815	serine threonine protein kinase
HEP73_04265	COG0589	response to stress
HEP73_04268	COG3568	Endonuclease Exonuclease Phosphatase
HEP73_04269	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP73_04270	COG0392	lysyltransferase activity
HEP73_04273	COG3275	phosphorelay sensor kinase activity
HEP73_04274	COG3279	Response regulator of the LytR AlgR family
HEP73_04276	COG0210	DNA helicase
HEP73_04294	COG0463	Glycosyl transferase, family 2
HEP73_04296	COG1475	DNA binding
HEP73_04297	COG1192	Involved in chromosome partitioning
HEP73_04298	COG0357	Ribosomal RNA small subunit methyltransferase G
HEP73_04300	COG2091	lysine biosynthetic process via aminoadipic acid
HEP73_04305	COG1011	Hydrolase
HEP73_04306	COG0477	Major facilitator Superfamily
HEP73_04310	COG1971	Probably functions as a manganese efflux pump
HEP73_04313	COG0457	Tetratricopeptide repeat
HEP73_04314	COG2205	protein histidine kinase activity
HEP73_04316	COG5001	Diguanylate cyclase
HEP73_04317	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP73_04318	COG3459	Glycosyltransferase 36 associated
HEP73_04319	COG2211	Major facilitator Superfamily
HEP73_04320	COG3265	gluconokinase activity
HEP73_04321	COG2155	Conserved Protein
HEP73_04322	COG2094	Belongs to the DNA glycosylase MPG family
HEP73_04325	COG2911	Protein conserved in bacteria
HEP73_04326	COG0729	surface antigen
HEP73_04330	COG3132	Protein of unknown function, DUF480
HEP73_04336	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HEP73_04337	COG0284	orotidine-5'-phosphate decarboxylase activity
HEP73_04340	COG1609	Transcriptional regulator
HEP73_04343	COG2937	Belongs to the GPAT DAPAT family
HEP73_04347	COG2211	Major facilitator Superfamily
HEP73_04350	COG3693	PFAM glycoside hydrolase, family 10
HEP73_04352	COG3250	beta-galactosidase activity
HEP73_04356	COG3386	PFAM SMP-30 Gluconolaconase
HEP73_04358	COG0667	Aldo Keto reductase
HEP73_04359	COG0583	DNA-binding transcription factor activity
HEP73_04370	COG0246	Mannitol dehydrogenase
HEP73_04371	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP73_04373	COG4948	Mandelate Racemase Muconate Lactonizing
HEP73_04375	COG3661	Belongs to the glycosyl hydrolase 67 family
HEP73_04377	COG2115	Belongs to the xylose isomerase family
HEP73_04379	COG0037	tRNA processing
HEP73_04382	COG0840	transmembrane signaling receptor activity
HEP73_04384	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HEP73_04386	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP73_04388	COG0805	protein transport
HEP73_04390	COG0519	Catalyzes the synthesis of GMP from XMP
HEP73_04390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP73_04395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEP73_04398	COG0210	DNA helicase
HEP73_04400	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HEP73_04403	COG0515	serine threonine protein kinase
HEP73_04403	COG2815	serine threonine protein kinase
HEP73_04405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP73_04410	COG1119	ATPase activity
HEP73_04413	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HEP73_04415	COG1335	isochorismatase
HEP73_04419	COG1733	regulation of RNA biosynthetic process
HEP73_04423	COG0706	membrane insertase activity
HEP73_04424	COG0594	ribonuclease P activity