locus-tag	class	description
DGN21_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DGN21_00025	COG0187	DNA topoisomerase II activity
DGN21_00035	COG0501	Belongs to the peptidase M48B family
DGN21_00070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DGN21_00080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN21_00110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DGN21_00115	COG0793	Belongs to the peptidase S41A family
DGN21_00120	COG4942	peptidase
DGN21_00130	COG2234	aminopeptidase activity
DGN21_00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN21_00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN21_00155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN21_00160	COG1064	alcohol dehydrogenase
DGN21_00170	COG0493	'glutamate synthase
DGN21_00175	COG0070	glutamate synthase
DGN21_00175	COG0067	glutamate synthase
DGN21_00175	COG0069	glutamate synthase activity
DGN21_00205	COG3459	Glycosyltransferase 36 associated
DGN21_00210	COG2366	antibiotic biosynthetic process
DGN21_00215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGN21_00245	COG1111	helicase
DGN21_00245	COG1205	dead DEAH box helicase
DGN21_00250	COG1272	protein, Hemolysin III
DGN21_00275	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_00295	COG0583	DNA-binding transcription factor activity
DGN21_00300	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_00315	COG1733	regulation of RNA biosynthetic process
DGN21_00325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DGN21_00330	COG0210	DNA helicase
DGN21_00365	COG1733	regulation of RNA biosynthetic process
DGN21_00370	COG3237	CsbD-like
DGN21_00405	COG0657	acetylesterase activity
DGN21_00415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN21_00465	COG0714	Associated with various cellular activities
DGN21_00490	COG0596	Alpha beta hydrolase
DGN21_00500	COG1309	transcriptional regulator
DGN21_00530	COG4772	TonB-dependent receptor
DGN21_00540	COG0662	Cupin 2, conserved barrel domain protein
DGN21_00545	COG1012	belongs to the aldehyde dehydrogenase family
DGN21_00575	COG1304	FMN binding
DGN21_00580	COG1755	Isoprenylcysteine carboxyl methyltransferase
DGN21_00585	COG4585	Histidine kinase
DGN21_00590	COG2197	response regulator
DGN21_00610	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DGN21_00760	COG0366	Alpha amylase catalytic
DGN21_00765	COG0366	Alpha amylase catalytic
DGN21_00770	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN21_00805	COG2755	lipolytic protein G-D-S-L family
DGN21_00815	COG0657	acetylesterase activity
DGN21_00815	COG2755	lipolytic protein G-D-S-L family
DGN21_00825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DGN21_00840	COG3507	Belongs to the glycosyl hydrolase 43 family
DGN21_00845	COG1609	Transcriptional regulator
DGN21_00850	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DGN21_00855	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_00865	COG2755	lipolytic protein G-D-S-L family
DGN21_00875	COG3186	Phenylalanine-4-hydroxylase
DGN21_00880	COG1522	sequence-specific DNA binding
DGN21_00890	COG1752	Esterase of the alpha-beta hydrolase superfamily
DGN21_00915	COG1125	glycine betaine transport
DGN21_00915	COG0517	IMP dehydrogenase activity
DGN21_00930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGN21_00935	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DGN21_00965	COG0489	protein tyrosine kinase activity
DGN21_00970	COG2062	phosphohistidine phosphatase, SixA
DGN21_00975	COG2353	YceI-like domain
DGN21_00980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN21_01010	COG1881	PFAM PEBP family protein
DGN21_01025	COG0174	glutamine synthetase
DGN21_01030	COG0347	Belongs to the P(II) protein family
DGN21_01035	COG0004	ammonium transporteR
DGN21_01040	COG3852	Histidine kinase
DGN21_01045	COG2204	response regulator
DGN21_01050	COG2032	superoxide dismutase activity
DGN21_01055	COG2032	superoxide dismutase activity
DGN21_01060	COG0346	lactoylglutathione lyase activity
DGN21_01070	COG0183	Belongs to the thiolase family
DGN21_01110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DGN21_01120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DGN21_01130	COG0028	Belongs to the TPP enzyme family
DGN21_01135	COG2205	protein histidine kinase activity
DGN21_01160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DGN21_01175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN21_01185	COG0596	Alpha beta hydrolase
DGN21_01190	COG0727	PFAM Uncharacterised protein family (UPF0153)
DGN21_01195	COG0318	PFAM AMP-dependent synthetase and ligase
DGN21_01200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN21_01215	COG1181	Belongs to the D-alanine--D-alanine ligase family
DGN21_01235	COG0564	pseudouridine synthase activity
DGN21_01255	COG1446	asparaginase
DGN21_01260	COG0339	signal peptide processing
DGN21_01280	COG0583	DNA-binding transcription factor activity
DGN21_01285	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DGN21_01290	COG2224	Isocitrate lyase
DGN21_01320	COG4770	biotin carboxylase activity
DGN21_01325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DGN21_01330	COG1960	acyl-CoA dehydrogenase activity
DGN21_01385	COG0523	cobalamin synthesis protein
DGN21_01390	COG0697	spore germination
DGN21_01400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DGN21_01410	COG1846	Transcriptional regulator
DGN21_01415	COG1764	response to oxidative stress
DGN21_01440	COG0656	L-ascorbic acid biosynthetic process
DGN21_01445	COG2130	NADP-dependent
DGN21_01460	COG1187	pseudouridine synthase activity
DGN21_01470	COG1643	Atp-dependent helicase
DGN21_01475	COG0840	transmembrane signaling receptor activity
DGN21_01485	COG4807	Protein conserved in bacteria
DGN21_01490	COG2351	hydroxyisourate hydrolase activity
DGN21_01495	COG2072	flavoprotein involved in K transport
DGN21_01515	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DGN21_01550	COG1957	nucleoside hydrolase
DGN21_01575	COG0084	hydrolase, TatD family'
DGN21_01585	COG0583	DNA-binding transcription factor activity
DGN21_01590	COG2814	Major facilitator Superfamily
DGN21_01600	COG2267	carboxylic ester hydrolase activity
DGN21_01625	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DGN21_01630	COG1902	pentaerythritol trinitrate reductase activity
DGN21_01650	COG2223	nitrite transmembrane transporter activity
DGN21_01655	COG0745	RESPONSE REGULATOR receiver
DGN21_01660	COG2205	protein histidine kinase activity
DGN21_01665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN21_01685	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_01705	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DGN21_01710	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGN21_01715	COG0583	DNA-binding transcription factor activity
DGN21_01740	COG0702	epimerase
DGN21_01745	COG1733	regulation of RNA biosynthetic process
DGN21_01755	COG0840	transmembrane signaling receptor activity
DGN21_01850	COG0129	dihydroxy-acid dehydratase activity
DGN21_01870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DGN21_01875	COG2814	Major facilitator Superfamily
DGN21_01925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DGN21_01930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DGN21_01960	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DGN21_01965	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DGN21_01975	COG3485	protocatechuate 3,4-dioxygenase
DGN21_01980	COG3485	protocatechuate 3,4-dioxygenase
DGN21_01990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN21_01995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DGN21_02005	COG1414	Transcriptional regulator
DGN21_02015	COG0657	acetylesterase activity
DGN21_02025	COG0445	tRNA wobble uridine modification
DGN21_02035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DGN21_02075	COG0156	8-amino-7-oxononanoate synthase activity
DGN21_02080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DGN21_02085	COG1040	competence protein
DGN21_02105	COG3264	Mechanosensitive ion channel
DGN21_02105	COG1511	domain protein
DGN21_02110	COG1368	sulfuric ester hydrolase activity
DGN21_02115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGN21_02130	COG0297	glycogen (starch) synthase activity
DGN21_02135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN21_02140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DGN21_02165	COG0702	epimerase
DGN21_02170	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_02205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN21_02220	COG0513	Belongs to the DEAD box helicase family
DGN21_02230	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGN21_02245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DGN21_02260	COG3104	oligopeptide transport
DGN21_02280	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DGN21_02295	COG1320	monovalent cation:proton antiporter activity
DGN21_02300	COG2212	antiporter activity
DGN21_02310	COG0651	ATP synthesis coupled electron transport
DGN21_02315	COG1006	Multisubunit Na H antiporter MnhC subunit
DGN21_02320	COG2111	Na H antiporter
DGN21_02320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGN21_02340	COG3179	chitinase
DGN21_02365	COG0484	heat shock protein binding
DGN21_02385	COG1597	lipid kinase activity
DGN21_02410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DGN21_02415	COG0134	indole-3-glycerol-phosphate synthase activity
DGN21_02425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN21_02440	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DGN21_02450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DGN21_02465	COG1051	belongs to the nudix hydrolase family
DGN21_02505	COG0316	Belongs to the HesB IscA family
DGN21_02520	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DGN21_02545	COG2814	Major facilitator Superfamily
DGN21_02550	COG1289	transmembrane transporter activity
DGN21_02555	COG0151	Belongs to the GarS family
DGN21_02560	COG0138	bifunctional purine biosynthesis protein purh
DGN21_02575	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DGN21_02595	COG2264	protein methyltransferase activity
DGN21_02610	COG0439	Biotin carboxylase
DGN21_02620	COG0511	ligase activity, forming carbon-carbon bonds
DGN21_02625	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DGN21_02635	COG1324	tolerance protein
DGN21_02640	COG2356	endonuclease I
DGN21_02660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DGN21_02685	COG3712	iron ion homeostasis
DGN21_02715	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DGN21_02745	COG2353	YceI-like domain
DGN21_02765	COG3052	prosthetic group binding
DGN21_02800	COG1802	Transcriptional regulator
DGN21_02805	COG0546	phosphoglycolate phosphatase activity
DGN21_02855	COG0270	DNA (cytosine-5-)-methyltransferase activity
DGN21_02940	COG2207	Transcriptional regulator
DGN21_02945	COG0300	oxidoreductase activity
DGN21_02950	COG1595	DNA-templated transcription, initiation
DGN21_02960	COG4206	TonB-dependent receptor
DGN21_02965	COG0823	Involved in the tonB-independent uptake of proteins
DGN21_02965	COG1506	peptidase
DGN21_03010	COG0435	Glutathione S-transferase
DGN21_03045	COG0823	Involved in the tonB-independent uptake of proteins
DGN21_03045	COG1506	peptidase
DGN21_03095	COG0697	spore germination
DGN21_03110	COG4305	rare lipoprotein A
DGN21_03115	COG1113	amino acid transport
DGN21_03185	COG0840	transmembrane signaling receptor activity
DGN21_03190	COG5297	Belongs to the glycosyl hydrolase family 6
DGN21_03190	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN21_03195	COG0659	secondary active sulfate transmembrane transporter activity
DGN21_03215	COG2943	transferase activity, transferring hexosyl groups
DGN21_03225	COG3275	phosphorelay sensor kinase activity
DGN21_03235	COG0181	hydroxymethylbilane synthase activity
DGN21_03260	COG1505	serine-type exopeptidase activity
DGN21_03265	COG0436	Aminotransferase
DGN21_03280	COG2832	Protein of unknown function (DUF454)
DGN21_03290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DGN21_03305	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DGN21_03335	COG2226	methyltransferase
DGN21_03340	COG3300	MHYT domain
DGN21_03340	COG5001	Diguanylate cyclase
DGN21_03345	COG0308	aminopeptidase N
DGN21_03380	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DGN21_03390	COG3284	Transcriptional regulator
DGN21_03395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGN21_03400	COG1077	Cell shape determining protein MreB Mrl
DGN21_03405	COG1792	Involved in formation and maintenance of cell shape
DGN21_03420	COG0772	Belongs to the SEDS family
DGN21_03435	COG2951	lytic endotransglycosylase activity
DGN21_03440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DGN21_03445	COG1686	Belongs to the peptidase S11 family
DGN21_03460	COG2921	Belongs to the UPF0250 family
DGN21_03465	COG0321	lipoyl(octanoyl) transferase activity
DGN21_03470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DGN21_03485	COG0583	DNA-binding transcription factor activity
DGN21_03495	COG1051	belongs to the nudix hydrolase family
DGN21_03495	COG1056	cytidyltransferase-related domain
DGN21_03530	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DGN21_03535	COG0673	inositol 2-dehydrogenase activity
DGN21_03540	COG2823	Periplasmic or secreted lipoprotein
DGN21_03545	COG4251	negative regulation of phosphorylation
DGN21_03550	COG0784	Response regulator, receiver
DGN21_03555	COG4191	Histidine kinase
DGN21_03560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DGN21_03565	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_03615	COG1459	type II secretion system
DGN21_03640	COG3156	type II secretion system protein K
DGN21_03665	COG3250	beta-galactosidase activity
DGN21_03680	COG2188	Transcriptional regulator
DGN21_03690	COG1609	Transcriptional regulator
DGN21_03695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGN21_03700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DGN21_03710	COG0617	tRNA 3'-terminal CCA addition
DGN21_03730	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DGN21_03735	COG1012	belongs to the aldehyde dehydrogenase family
DGN21_03740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DGN21_03750	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGN21_03765	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DGN21_03770	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DGN21_03785	COG2205	protein histidine kinase activity
DGN21_03815	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DGN21_03820	COG3791	Glutathione-dependent formaldehyde-activating
DGN21_03825	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DGN21_03830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DGN21_03840	COG0697	spore germination
DGN21_03860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DGN21_03865	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DGN21_03875	COG2205	protein histidine kinase activity
DGN21_03880	COG0745	RESPONSE REGULATOR receiver
DGN21_03885	COG0277	FAD linked oxidase domain protein
DGN21_03890	COG1988	membrane-bound metal-dependent
DGN21_03895	COG0792	nuclease activity
DGN21_03925	COG0275	rRNA processing
DGN21_03930	COG3116	cell division
DGN21_03940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DGN21_03945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DGN21_03950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DGN21_03960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DGN21_03965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGN21_03970	COG1181	Belongs to the D-alanine--D-alanine ligase family
DGN21_03975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DGN21_04000	COG0739	heme binding
DGN21_04005	COG0653	protein targeting
DGN21_04015	COG0494	nUDIX hydrolase
DGN21_04030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DGN21_04035	COG0604	alcohol dehydrogenase
DGN21_04035	COG3321	synthase
DGN21_04035	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_04045	COG0366	Alpha amylase catalytic
DGN21_04080	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DGN21_04100	COG2885	chlorophyll binding
DGN21_04110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DGN21_04125	COG4106	trans-aconitate 2-methyltransferase activity
DGN21_04130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGN21_04145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DGN21_04155	COG0667	Aldo Keto reductase
DGN21_04165	COG4771	TonB-dependent receptor
DGN21_04195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGN21_04200	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DGN21_04210	COG2175	clavaminate synthase activity
DGN21_04220	COG4181	ATPase activity
DGN21_04235	COG0642	Histidine kinase
DGN21_04245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DGN21_04265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DGN21_04270	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DGN21_04280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DGN21_04285	COG2967	ApaG domain
DGN21_04290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DGN21_04295	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DGN21_04310	COG0123	including yeast histone deacetylase and acetoin utilization protein
DGN21_04315	COG2096	Adenosyltransferase
DGN21_04325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN21_04330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN21_04360	COG3384	dioxygenase
DGN21_04365	COG0583	DNA-binding transcription factor activity
DGN21_04370	COG0318	PFAM AMP-dependent synthetase and ligase
DGN21_04380	COG1024	Enoyl-CoA hydratase
DGN21_04430	COG0697	spore germination
DGN21_04435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN21_04460	COG2197	response regulator
DGN21_04470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DGN21_04480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DGN21_04485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN21_04490	COG0583	DNA-binding transcription factor activity
DGN21_04495	COG3634	alkyl hydroperoxide reductase activity
DGN21_04505	COG2890	protein-(glutamine-N5) methyltransferase activity
DGN21_04525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGN21_04525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGN21_04555	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DGN21_04595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DGN21_04600	COG1404	Belongs to the peptidase S8 family
DGN21_04605	COG1404	Belongs to the peptidase S8 family
DGN21_04610	COG1404	Belongs to the peptidase S8 family
DGN21_04615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DGN21_04635	COG1295	ribonuclease BN
DGN21_04640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN21_04645	COG1254	Belongs to the acylphosphatase family
DGN21_04660	COG0521	Mo-molybdopterin cofactor biosynthetic process
DGN21_04670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DGN21_04675	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DGN21_04685	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DGN21_04700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DGN21_04705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DGN21_04710	COG0193	aminoacyl-tRNA hydrolase activity
DGN21_04715	COG0012	GTP binding
DGN21_04735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGN21_04750	COG0250	Participates in transcription elongation, termination and antitermination
DGN21_04755	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DGN21_04760	COG0081	regulation of translation
DGN21_04765	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DGN21_04770	COG0222	ribosome binding
DGN21_04780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DGN21_04785	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DGN21_04795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DGN21_04800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DGN21_04805	COG0051	transcription antitermination factor activity, RNA binding
DGN21_04825	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DGN21_04835	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DGN21_04850	COG0255	Belongs to the universal ribosomal protein uL29 family
DGN21_04865	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DGN21_04885	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DGN21_04900	COG1841	ribosomal large subunit assembly
DGN21_04910	COG0201	protein transport
DGN21_04935	COG0203	ribosomal protein L17
DGN21_04945	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DGN21_04955	COG0154	amidase activity
DGN21_04965	COG1217	gtp-binding protein TYPA
DGN21_04970	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DGN21_04980	COG0625	glutathione transferase activity
DGN21_05000	COG0446	pyridine nucleotide-disulphide oxidoreductase
DGN21_05000	COG1902	pentaerythritol trinitrate reductase activity
DGN21_05005	COG0604	alcohol dehydrogenase
DGN21_05015	COG2885	chlorophyll binding
DGN21_05040	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DGN21_05045	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DGN21_05050	COG4208	sulfate ABC transporter
DGN21_05055	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DGN21_05085	COG0406	alpha-ribazole phosphatase activity
DGN21_05100	COG0285	dihydrofolate synthase activity
DGN21_05120	COG2833	Protein of unknown function (DUF455)
DGN21_05125	COG3291	Pkd domain containing protein
DGN21_05135	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN21_05140	COG0671	phosphoesterase, PA-phosphatase related
DGN21_05145	COG0438	transferase activity, transferring glycosyl groups
DGN21_05155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DGN21_05170	COG4783	chaperone-mediated protein folding
DGN21_05185	COG0473	3-isopropylmalate dehydrogenase activity
DGN21_05220	COG4191	Histidine kinase
DGN21_05220	COG0784	Response regulator, receiver
DGN21_05230	COG0544	peptidyl-prolyl cis-trans isomerase activity
DGN21_05240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DGN21_05270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGN21_05280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN21_05305	COG0631	protein serine/threonine phosphatase activity
DGN21_05320	COG0859	PFAM glycosyl transferase family 9
DGN21_05330	COG1234	tRNA 3'-trailer cleavage
DGN21_05335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DGN21_05340	COG0315	cyclic pyranopterin monophosphate synthase activity
DGN21_05345	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DGN21_05350	COG0314	molybdopterin synthase activity
DGN21_05370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DGN21_05375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DGN21_05380	COG0537	adenosine 5'-monophosphoramidase activity
DGN21_05400	COG0714	Associated with various cellular activities
DGN21_05420	COG0424	maF-like protein
DGN21_05425	COG1399	metal-binding, possibly nucleic acid-binding protein
DGN21_05430	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DGN21_05435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN21_05445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DGN21_05450	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_05465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DGN21_05470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DGN21_05495	COG3829	transcription factor binding
DGN21_05515	COG3609	addiction module antidote protein, CC2985 family
DGN21_05545	COG2373	Large extracellular alpha-helical protein
DGN21_05570	COG4953	penicillin-binding protein 1C
DGN21_05580	COG0678	peroxiredoxin activity
DGN21_05600	COG0330	HflC and HflK could
DGN21_05605	COG0330	HflC and HflK could
DGN21_05620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DGN21_05625	COG0308	aminopeptidase N
DGN21_05650	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_05655	COG1309	transcriptional regulator
DGN21_05685	COG0732	type I restriction modification DNA specificity domain
DGN21_05700	COG1309	transcriptional regulator
DGN21_05710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGN21_05725	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_05735	COG3537	Alpha-1,2-mannosidase
DGN21_05780	COG2323	membrane
DGN21_05795	COG2271	Major facilitator Superfamily
DGN21_05820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGN21_05825	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGN21_05830	COG2080	2 iron, 2 sulfur cluster binding
DGN21_05870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGN21_05885	COG0587	DNA-directed DNA polymerase activity
DGN21_05905	COG1297	OPT oligopeptide transporter protein
DGN21_05925	COG1506	peptidase
DGN21_05925	COG0823	Involved in the tonB-independent uptake of proteins
DGN21_05940	COG1917	Cupin 2, conserved barrel domain protein
DGN21_05940	COG2207	Transcriptional regulator
DGN21_05950	COG0753	catalase activity
DGN21_05955	COG0656	L-ascorbic acid biosynthetic process
DGN21_05960	COG2272	Belongs to the type-B carboxylesterase lipase family
DGN21_05965	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGN21_05965	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DGN21_05970	COG2814	Major facilitator Superfamily
DGN21_05995	COG2194	sulfuric ester hydrolase activity
DGN21_06005	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DGN21_06010	COG0745	RESPONSE REGULATOR receiver
DGN21_06015	COG5002	protein histidine kinase activity
DGN21_06025	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DGN21_06030	COG2894	cell division
DGN21_06035	COG0850	regulation of cytokinetic process
DGN21_06050	COG4585	Histidine kinase
DGN21_06055	COG2197	response regulator
DGN21_06070	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DGN21_06105	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DGN21_06115	COG1595	DNA-templated transcription, initiation
DGN21_06125	COG1946	Acyl-CoA thioesterase
DGN21_06130	COG1024	Enoyl-CoA hydratase
DGN21_06140	COG0824	Thioesterase
DGN21_06145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DGN21_06155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DGN21_06160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DGN21_06170	COG0728	peptidoglycan biosynthetic process
DGN21_06175	COG0196	riboflavin kinase activity
DGN21_06180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DGN21_06185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DGN21_06190	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DGN21_06205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DGN21_06210	COG1845	cytochrome c oxidase, subunit III
DGN21_06215	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DGN21_06235	COG3152	Membrane
DGN21_06245	COG2207	Transcriptional regulator
DGN21_06250	COG0326	Molecular chaperone. Has ATPase activity
DGN21_06270	COG1902	pentaerythritol trinitrate reductase activity
DGN21_06275	COG1366	Belongs to the anti-sigma-factor antagonist family
DGN21_06280	COG1366	Belongs to the anti-sigma-factor antagonist family
DGN21_06285	COG2172	sigma factor antagonist activity
DGN21_06315	COG4771	TonB-dependent receptor
DGN21_06325	COG5507	3-demethylubiquinone-9 3-methyltransferase
DGN21_06330	COG2205	protein histidine kinase activity
DGN21_06340	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGN21_06345	COG2205	protein histidine kinase activity
DGN21_06345	COG3437	response regulator, receiver
DGN21_06345	COG3850	Histidine kinase
DGN21_06345	COG4999	Histidine kinase
DGN21_06350	COG0784	Response regulator, receiver
DGN21_06350	COG4191	Histidine kinase
DGN21_06380	COG3534	alpha-L-arabinofuranosidase
DGN21_06395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DGN21_06400	COG2070	2-Nitropropane dioxygenase
DGN21_06420	COG0336	Belongs to the RNA methyltransferase TrmD family
DGN21_06430	COG0534	Mate efflux family protein
DGN21_06440	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DGN21_06450	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DGN21_06465	COG3250	beta-galactosidase activity
DGN21_06470	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DGN21_06480	COG1396	sequence-specific DNA binding
DGN21_06480	COG3800	Transcriptional regulator
DGN21_06490	COG1960	acyl-CoA dehydrogenase activity
DGN21_06530	COG0457	Tetratricopeptide repeat
DGN21_06540	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGN21_06540	COG1024	Enoyl-CoA hydratase
DGN21_06555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGN21_06575	COG0571	ribonuclease III activity
DGN21_06580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DGN21_06585	COG1381	Involved in DNA repair and RecF pathway recombination
DGN21_06600	COG2954	triphosphatase activity
DGN21_06610	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DGN21_06615	COG3046	protein related to deoxyribodipyrimidine photolyase
DGN21_06620	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN21_06625	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DGN21_06630	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DGN21_06635	COG1278	Cold shock
DGN21_06640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN21_06650	COG1201	RNA secondary structure unwinding
DGN21_06655	COG1793	dna ligase
DGN21_06665	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DGN21_06665	COG1793	dna ligase
DGN21_06700	COG0183	Belongs to the thiolase family
DGN21_06720	COG1451	nucleotide metabolic process
DGN21_06725	COG5487	UPF0391 membrane protein
DGN21_06735	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DGN21_06775	COG1047	Peptidyl-prolyl cis-trans
DGN21_06785	COG2824	Alkylphosphonate utilization operon protein PhnA
DGN21_06805	COG1902	pentaerythritol trinitrate reductase activity
DGN21_06810	COG2814	Major facilitator Superfamily
DGN21_06845	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DGN21_06845	COG0392	lysyltransferase activity
DGN21_06855	COG0251	oxidation-reduction process
DGN21_06860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGN21_06875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DGN21_06900	COG1595	DNA-templated transcription, initiation
DGN21_06915	COG2878	Part of a membrane complex involved in electron transport
DGN21_06925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN21_06925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN21_06940	COG1131	(ABC) transporter
DGN21_06945	COG0346	lactoylglutathione lyase activity
DGN21_06950	COG0833	amino acid
DGN21_06955	COG2040	homocysteine
DGN21_06975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DGN21_06995	COG1695	Transcriptional regulator
DGN21_07025	COG1981	membrane
DGN21_07040	COG0825	malonyl-CoA metabolic process
DGN21_07055	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN21_07060	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN21_07070	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DGN21_07085	COG0750	zinc metalloprotease
DGN21_07090	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DGN21_07095	COG0575	Belongs to the CDS family
DGN21_07105	COG0233	cytoplasmic translational termination
DGN21_07110	COG0528	UMP kinase activity
DGN21_07120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DGN21_07125	COG0052	Belongs to the universal ribosomal protein uS2 family
DGN21_07180	COG1393	Belongs to the ArsC family
DGN21_07185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGN21_07195	COG0367	asparagine synthase
DGN21_07205	COG4774	siderophore transport
DGN21_07250	COG1566	PFAM secretion protein HlyD family protein
DGN21_07255	COG2814	Major facilitator Superfamily
DGN21_07310	COG0339	signal peptide processing
DGN21_07320	COG0386	Belongs to the glutathione peroxidase family
DGN21_07345	COG0288	reversible hydration of carbon dioxide
DGN21_07355	COG2839	Protein conserved in bacteria
DGN21_07375	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DGN21_07380	COG0084	hydrolase, TatD family'
DGN21_07395	COG1960	acyl-CoA dehydrogenase activity
DGN21_07410	COG0367	asparagine synthase
DGN21_07420	COG0305	Participates in initiation and elongation during chromosome replication
DGN21_07425	COG0415	Belongs to the DNA photolyase family
DGN21_07440	COG0583	DNA-binding transcription factor activity
DGN21_07455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN21_07485	COG3706	GGDEF domain
DGN21_07505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DGN21_07520	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN21_07530	COG0497	DNA recombination
DGN21_07535	COG1420	regulation of RNA biosynthetic process
DGN21_07540	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DGN21_07545	COG0443	Heat shock 70 kDa protein
DGN21_07550	COG0484	heat shock protein binding
DGN21_07560	COG1605	Chorismate mutase
DGN21_07560	COG0287	Prephenate dehydrogenase
DGN21_07580	COG2274	protein secretion by the type I secretion system
DGN21_07585	COG0583	DNA-binding transcription factor activity
DGN21_07590	COG1132	(ABC) transporter
DGN21_07625	COG2850	peptidyl-arginine hydroxylation
DGN21_07640	COG1253	flavin adenine dinucleotide binding
DGN21_07670	COG1131	(ABC) transporter
DGN21_07675	COG1725	Transcriptional regulator
DGN21_07685	COG0386	Belongs to the glutathione peroxidase family
DGN21_07700	COG2900	Belongs to the SlyX family
DGN21_07710	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DGN21_07710	COG2755	lipolytic protein G-D-S-L family
DGN21_07730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGN21_07740	COG0646	methionine synthase
DGN21_07740	COG1410	methionine synthase
DGN21_07745	COG0646	methionine synthase
DGN21_07745	COG1410	methionine synthase
DGN21_07750	COG2226	methyltransferase
DGN21_07755	COG1960	acyl-CoA dehydrogenase activity
DGN21_07770	COG0557	exoribonuclease II activity
DGN21_07780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGN21_07800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DGN21_07810	COG0704	Plays a role in the regulation of phosphate uptake
DGN21_07815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DGN21_07820	COG0581	inorganic phosphate transmembrane transporter activity
DGN21_07825	COG0573	inorganic phosphate transmembrane transporter activity
DGN21_07830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DGN21_07855	COG0659	secondary active sulfate transmembrane transporter activity
DGN21_07860	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DGN21_07870	COG1024	Enoyl-CoA hydratase
DGN21_07880	COG0494	nUDIX hydrolase
DGN21_07930	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DGN21_07940	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DGN21_07955	COG2925	Exonuclease
DGN21_07960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN21_07965	COG3844	kynureninase activity
DGN21_07980	COG0662	Cupin 2, conserved barrel domain protein
DGN21_07985	COG0288	reversible hydration of carbon dioxide
DGN21_08035	COG2808	Putative FMN-binding domain
DGN21_08055	COG0017	Asparaginyl-tRNA synthetase
DGN21_08065	COG0316	Belongs to the HesB IscA family
DGN21_08090	COG3115	cell septum assembly
DGN21_08100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN21_08105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DGN21_08110	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DGN21_08120	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DGN21_08130	COG4993	Dehydrogenase
DGN21_08145	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DGN21_08155	COG2986	histidine ammonia-lyase
DGN21_08160	COG1228	amidohydrolase
DGN21_08195	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DGN21_08200	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DGN21_08205	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DGN21_08210	COG0077	Prephenate dehydratase
DGN21_08210	COG1605	Chorismate mutase
DGN21_08215	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DGN21_08230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DGN21_08235	COG0583	DNA-binding transcription factor activity
DGN21_08250	COG1752	Esterase of the alpha-beta hydrolase superfamily
DGN21_08280	COG3685	Protein conserved in bacteria
DGN21_08340	COG2003	Belongs to the UPF0758 family
DGN21_08360	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DGN21_08445	COG0840	transmembrane signaling receptor activity
DGN21_08480	COG0840	transmembrane signaling receptor activity
DGN21_08500	COG4191	Histidine kinase
DGN21_08500	COG0784	Response regulator, receiver
DGN21_08505	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DGN21_08525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DGN21_08545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DGN21_08550	COG1404	Belongs to the peptidase S8 family
DGN21_08560	COG1595	DNA-templated transcription, initiation
DGN21_08610	COG2244	polysaccharide biosynthetic process
DGN21_08640	COG2264	protein methyltransferase activity
DGN21_08645	COG0297	glycogen (starch) synthase activity
DGN21_08650	COG0438	transferase activity, transferring glycosyl groups
DGN21_08665	COG1136	(ABC) transporter
DGN21_08670	COG1132	(ABC) transporter
DGN21_08675	COG0477	Major facilitator Superfamily
DGN21_08680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGN21_08695	COG1253	flavin adenine dinucleotide binding
DGN21_08750	COG0148	phosphopyruvate hydratase activity
DGN21_08760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DGN21_08765	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DGN21_08780	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DGN21_08785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGN21_08790	COG1238	metal cluster binding
DGN21_08805	COG1534	Rna-binding protein
DGN21_08810	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DGN21_08820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DGN21_08835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DGN21_08840	COG1546	Belongs to the CinA family
DGN21_08850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DGN21_08855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGN21_08860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DGN21_08865	COG2137	regulation of response to DNA damage stimulus
DGN21_08870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DGN21_08875	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DGN21_08890	COG1741	Belongs to the pirin family
DGN21_08895	COG0583	DNA-binding transcription factor activity
DGN21_08920	COG0351	phosphomethylpyrimidine kinase
DGN21_08920	COG0352	thiamine-phosphate diphosphorylase activity
DGN21_08935	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DGN21_08940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DGN21_08955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGN21_08965	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DGN21_08970	COG3734	2-keto-3-deoxy-galactonokinase
DGN21_08980	COG4948	Mandelate Racemase Muconate Lactonizing
DGN21_08985	COG0800	Aldolase
DGN21_09025	COG1501	Belongs to the glycosyl hydrolase 31 family
DGN21_09035	COG1070	Carbohydrate kinase
DGN21_09040	COG2115	Belongs to the xylose isomerase family
DGN21_09045	COG0477	Major facilitator Superfamily
DGN21_09065	COG0860	N-Acetylmuramoyl-L-alanine amidase
DGN21_09090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DGN21_09095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DGN21_09130	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN21_09145	COG4251	negative regulation of phosphorylation
DGN21_09145	COG5001	Diguanylate cyclase
DGN21_09145	COG3706	GGDEF domain
DGN21_09145	COG2203	Gaf domain
DGN21_09150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DGN21_09160	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DGN21_09170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DGN21_09175	COG0671	phosphoesterase, PA-phosphatase related
DGN21_09185	COG1794	racemase activity, acting on amino acids and derivatives
DGN21_09195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DGN21_09215	COG1012	belongs to the aldehyde dehydrogenase family
DGN21_09235	COG0778	Nitroreductase
DGN21_09240	COG1846	Transcriptional regulator
DGN21_09250	COG1215	transferase activity, transferring glycosyl groups
DGN21_09255	COG1649	PFAM Uncharacterised BCR, COG1649
DGN21_09255	COG0726	polysaccharide deacetylase
DGN21_09310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN21_09315	COG0124	histidyl-tRNA synthetase
DGN21_09330	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DGN21_09335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN21_09340	COG0131	Imidazoleglycerol-phosphate dehydratase
DGN21_09340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DGN21_09345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DGN21_09350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DGN21_09355	COG0107	imidazoleglycerol-phosphate synthase activity
DGN21_09360	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DGN21_09360	COG0140	phosphoribosyl-ATP diphosphatase activity
DGN21_09395	COG0531	amino acid
DGN21_09400	COG0531	amino acid
DGN21_09415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DGN21_09420	COG0277	FAD linked oxidase domain protein
DGN21_09440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGN21_09475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DGN21_09480	COG2258	MOSC domain
DGN21_09490	COG0505	Belongs to the CarA family
DGN21_09500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DGN21_09505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN21_09515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DGN21_09530	COG3279	Response regulator of the LytR AlgR family
DGN21_09540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DGN21_09550	COG0784	Response regulator, receiver
DGN21_09550	COG2198	Histidine kinase
DGN21_09550	COG2205	protein histidine kinase activity
DGN21_09555	COG1024	Enoyl-CoA hydratase
DGN21_09560	COG0318	PFAM AMP-dependent synthetase and ligase
DGN21_09590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN21_09615	COG0840	transmembrane signaling receptor activity
DGN21_09625	COG0835	chemotaxis
DGN21_09645	COG0840	transmembrane signaling receptor activity
DGN21_09650	COG0840	transmembrane signaling receptor activity
DGN21_09655	COG0840	transmembrane signaling receptor activity
DGN21_09660	COG0840	transmembrane signaling receptor activity
DGN21_09665	COG0840	transmembrane signaling receptor activity
DGN21_09685	COG0840	transmembrane signaling receptor activity
DGN21_09705	COG0745	RESPONSE REGULATOR receiver
DGN21_09715	COG0835	chemotaxis
DGN21_09725	COG1360	Flagellar Motor Protein
DGN21_09730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DGN21_09775	COG2198	Histidine kinase
DGN21_09775	COG0643	Histidine kinase
DGN21_09775	COG0784	Response regulator, receiver
DGN21_09825	COG3300	MHYT domain
DGN21_09825	COG5001	Diguanylate cyclase
DGN21_09830	COG1684	flagellar biosynthetic protein fliR
DGN21_09850	COG3190	flagellar
DGN21_09900	COG1677	Flagellar hook-basal body complex protein FliE
DGN21_09935	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_09940	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_09945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN21_09965	COG2201	protein-glutamate methylesterase activity
DGN21_09995	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DGN21_10000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DGN21_10015	COG1705	Flagellar rod assembly protein muramidase FlgJ
DGN21_10015	COG3951	Flagellar rod assembly protein muramidase FlgJ
DGN21_10020	COG1706	bacterial-type flagellum-dependent cell motility
DGN21_10025	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DGN21_10040	COG4787	bacterial-type flagellum-dependent cell motility
DGN21_10050	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DGN21_10055	COG1558	bacterial-type flagellum-dependent cell motility
DGN21_10060	COG1815	bacterial-type flagellum-dependent cell motility
DGN21_10065	COG0784	Response regulator, receiver
DGN21_10065	COG0835	chemotaxis
DGN21_10085	COG4191	Histidine kinase
DGN21_10125	COG0482	sulfurtransferase activity
DGN21_10140	COG0542	response to heat
DGN21_10150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DGN21_10160	COG0492	ferredoxin-NADP+ reductase activity
DGN21_10165	COG1674	ftsk spoiiie
DGN21_10180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DGN21_10185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DGN21_10190	COG0183	Belongs to the thiolase family
DGN21_10195	COG1024	Enoyl-CoA hydratase
DGN21_10195	COG1250	3-hydroxyacyl-CoA dehydrogenase
DGN21_10210	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DGN21_10220	COG1426	Protein conserved in bacteria
DGN21_10230	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN21_10235	COG1160	GTP binding
DGN21_10240	COG0303	'Molybdopterin
DGN21_10245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DGN21_10270	COG0708	Exodeoxyribonuclease III
DGN21_10280	COG0303	'Molybdopterin
DGN21_10285	COG0746	molybdenum cofactor guanylyltransferase activity
DGN21_10295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGN21_10295	COG1648	precorrin-2 dehydrogenase activity
DGN21_10305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DGN21_10310	COG2223	nitrite transmembrane transporter activity
DGN21_10315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DGN21_10325	COG0243	molybdopterin cofactor binding
DGN21_10350	COG5001	Diguanylate cyclase
DGN21_10395	COG4191	Histidine kinase
DGN21_10395	COG0784	Response regulator, receiver
DGN21_10445	COG0840	transmembrane signaling receptor activity
DGN21_10475	COG3781	membrane
DGN21_10485	COG2197	response regulator
DGN21_10500	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_10640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DGN21_10685	COG2366	antibiotic biosynthetic process
DGN21_10695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN21_10725	COG2154	pterin-4-alpha-carbinolamine dehydratase
DGN21_10735	COG0428	transporter
DGN21_10745	COG1530	ribonuclease E activity
DGN21_10755	COG1054	Belongs to the UPF0176 family
DGN21_10775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DGN21_10800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGN21_10805	COG0322	excinuclease ABC activity
DGN21_10815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DGN21_10820	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DGN21_10825	COG1663	tetraacyldisaccharide 4'-kinase activity
DGN21_10830	COG1132	(ABC) transporter
DGN21_10835	COG0848	biopolymer transport protein
DGN21_10840	COG0811	peptide transport
DGN21_10860	COG4591	ABC-type transport system involved in lipoprotein release permease component
DGN21_10870	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DGN21_10875	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DGN21_10890	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DGN21_10915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGN21_10920	COG0837	glucose binding
DGN21_10930	COG0129	dihydroxy-acid dehydratase activity
DGN21_10935	COG0800	Aldolase
DGN21_11005	COG2205	protein histidine kinase activity
DGN21_11005	COG5002	protein histidine kinase activity
DGN21_11005	COG0784	Response regulator, receiver
DGN21_11010	COG2183	response to ionizing radiation
DGN21_11020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN21_11020	COG0723	plastoquinol--plastocyanin reductase activity
DGN21_11035	COG3243	poly(R)-hydroxyalkanoic acid synthase
DGN21_11045	COG1183	phosphatidylcholine synthase activity
DGN21_11050	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_11075	COG0668	transmembrane transport
DGN21_11080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DGN21_11095	COG1914	H( )-stimulated, divalent metal cation uptake system
DGN21_11105	COG2814	Major facilitator Superfamily
DGN21_11120	COG1335	isochorismatase
DGN21_11135	COG2197	response regulator
DGN21_11155	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_11170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DGN21_11180	COG0475	glutathione-regulated potassium exporter activity
DGN21_11180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGN21_11185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DGN21_11200	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DGN21_11215	COG0539	negative regulation of cytoplasmic translation
DGN21_11220	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DGN21_11235	COG2957	Belongs to the agmatine deiminase family
DGN21_11240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGN21_11265	COG0395	ABC-type sugar transport system, permease component
DGN21_11270	COG1175	transmembrane transport
DGN21_11275	COG1653	transport
DGN21_11290	COG1609	Transcriptional regulator
DGN21_11300	COG2350	Protein conserved in bacteria
DGN21_11305	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DGN21_11310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DGN21_11315	COG1187	pseudouridine synthase activity
DGN21_11335	COG0436	Aminotransferase
DGN21_11340	COG4133	protoheme IX ABC transporter activity
DGN21_11360	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DGN21_11390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN21_11400	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DGN21_11405	COG4988	ABC transporter
DGN21_11415	COG1294	oxidase, subunit
DGN21_11460	COG0165	Argininosuccinate lyase
DGN21_11475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DGN21_11480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGN21_11485	COG0137	argininosuccinate synthase activity
DGN21_11490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DGN21_11500	COG0215	cysteine-tRNA ligase activity
DGN21_11505	COG2166	iron-sulfur cluster assembly
DGN21_11525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DGN21_11540	COG4303	Ethanolamine ammonia lyase large subunit
DGN21_11545	COG4302	ethanolamine ammonia-lyase activity
DGN21_11560	COG4677	pectinesterase activity
DGN21_11575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DGN21_11580	COG0402	S-adenosylhomocysteine deaminase activity
DGN21_11590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGN21_11600	COG5001	Diguanylate cyclase
DGN21_11600	COG3300	MHYT domain
DGN21_11615	COG0483	inositol monophosphate 1-phosphatase activity
DGN21_11620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DGN21_11635	COG0488	(ABC) transporter
DGN21_11640	COG0513	Belongs to the DEAD box helicase family
DGN21_11645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DGN21_11650	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DGN21_11660	COG0625	glutathione transferase activity
DGN21_11675	COG4681	YaeQ
DGN21_11680	COG2081	HI0933 family
DGN21_11695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN21_11700	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_11720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DGN21_11725	COG0860	N-Acetylmuramoyl-L-alanine amidase
DGN21_11735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DGN21_11735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGN21_11740	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGN21_11755	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DGN21_11785	COG0835	chemotaxis
DGN21_11790	COG0840	transmembrane signaling receptor activity
DGN21_11795	COG2094	Belongs to the DNA glycosylase MPG family
DGN21_11800	COG1201	RNA secondary structure unwinding
DGN21_11810	COG2969	positive regulation of protein catabolic process
DGN21_11815	COG0625	glutathione transferase activity
DGN21_11820	COG2857	Cytochrome c1
DGN21_11825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DGN21_11830	COG0723	plastoquinol--plastocyanin reductase activity
DGN21_11835	COG0741	lytic transglycosylase activity
DGN21_11850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGN21_11855	COG1702	phosphate starvation-inducible protein PhoH
DGN21_11870	COG4535	Mg2 and Co2 transporter CorC
DGN21_11885	COG1012	belongs to the aldehyde dehydrogenase family
DGN21_11895	COG1177	transmembrane transport
DGN21_11900	COG1176	ABC-type spermidine putrescine transport system, permease component I
DGN21_11905	COG3842	ATPase activity
DGN21_11925	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DGN21_11940	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DGN21_11945	COG0174	glutamine synthetase
DGN21_11950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN21_11960	COG2703	oxygen carrier activity
DGN21_11965	COG0477	Major facilitator Superfamily
DGN21_11975	COG0243	molybdopterin cofactor binding
DGN21_11985	COG2223	nitrite transmembrane transporter activity
DGN21_11990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DGN21_12000	COG2733	membrane
DGN21_12005	COG2205	protein histidine kinase activity
DGN21_12005	COG0784	Response regulator, receiver
DGN21_12005	COG5002	protein histidine kinase activity
DGN21_12015	COG0477	Major facilitator Superfamily
DGN21_12030	COG0300	oxidoreductase activity
DGN21_12040	COG1902	pentaerythritol trinitrate reductase activity
DGN21_12050	COG3321	synthase
DGN21_12050	COG0604	alcohol dehydrogenase
DGN21_12060	COG2902	Dehydrogenase
DGN21_12070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN21_12075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN21_12080	COG1609	Transcriptional regulator
DGN21_12085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGN21_12085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN21_12090	COG1105	Belongs to the carbohydrate kinase PfkB family
DGN21_12095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGN21_12095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DGN21_12105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DGN21_12115	COG1862	Preprotein translocase
DGN21_12125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DGN21_12165	COG3291	Pkd domain containing protein
DGN21_12175	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DGN21_12195	COG0742	ribosomal rna small subunit methyltransferase
DGN21_12200	COG0326	Molecular chaperone. Has ATPase activity
DGN21_12245	COG0531	amino acid
DGN21_12260	COG0006	proline dipeptidase activity
DGN21_12270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGN21_12285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN21_12290	COG3938	Belongs to the proline racemase family
DGN21_12300	COG0552	protein localization to endoplasmic reticulum
DGN21_12320	COG0784	Response regulator, receiver
DGN21_12320	COG4191	Histidine kinase
DGN21_12330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DGN21_12355	COG1960	acyl-CoA dehydrogenase activity
DGN21_12365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DGN21_12385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN21_12390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN21_12395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DGN21_12420	COG0438	transferase activity, transferring glycosyl groups
DGN21_12430	COG0438	transferase activity, transferring glycosyl groups
DGN21_12435	COG0438	transferase activity, transferring glycosyl groups
DGN21_12485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DGN21_12485	COG0072	phenylalanine-tRNA ligase activity
DGN21_12490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DGN21_12505	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DGN21_12510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DGN21_12530	COG2211	Major facilitator Superfamily
DGN21_12540	COG1082	Xylose isomerase domain protein TIM barrel
DGN21_12550	COG0366	Alpha amylase catalytic
DGN21_12560	COG3702	type iv secretory pathway
DGN21_12580	COG2948	multi-organism process
DGN21_12600	COG3505	Type IV secretory pathway VirD4
DGN21_12615	COG0556	nucleotide-excision repair
DGN21_12655	COG4969	Belongs to the N-Me-Phe pilin family
DGN21_12660	COG1611	Belongs to the LOG family
DGN21_12675	COG2095	MarC family integral membrane protein
DGN21_12680	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_12685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGN21_12720	COG1185	polyribonucleotide nucleotidyltransferase activity
DGN21_12725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DGN21_12730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DGN21_12735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DGN21_12740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DGN21_12745	COG0195	Participates in both transcription termination and antitermination
DGN21_12750	COG0779	Required for maturation of 30S ribosomal subunits
DGN21_12760	COG1007	ATP synthesis coupled electron transport
DGN21_12780	COG0839	Belongs to the complex I subunit 6 family
DGN21_12785	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN21_12790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DGN21_12795	COG1034	ATP synthesis coupled electron transport
DGN21_12800	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DGN21_12805	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DGN21_12815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN21_12825	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGN21_12845	COG4221	oxidoreductase activity
DGN21_12875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGN21_12880	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DGN21_12895	COG0133	tryptophan synthase activity
DGN21_12910	COG0101	tRNA pseudouridine synthase activity
DGN21_12925	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DGN21_12930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DGN21_12945	COG2890	protein-(glutamine-N5) methyltransferase activity
DGN21_12955	COG0688	phosphatidylethanolamine metabolic process
DGN21_12965	COG0433	COG0433 Predicted ATPase
DGN21_12970	COG0494	nUDIX hydrolase
DGN21_12985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGN21_13015	COG0717	Belongs to the dCTP deaminase family
DGN21_13025	COG0489	protein tyrosine kinase activity
DGN21_13050	COG3590	peptidase
DGN21_13075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGN21_13080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN21_13085	COG2311	Membrane
DGN21_13090	COG1047	Peptidyl-prolyl cis-trans
DGN21_13095	COG0791	NLP P60 protein
DGN21_13100	COG0791	NLP P60 protein
DGN21_13115	COG1301	dicarboxylic acid transport
DGN21_13120	COG1785	Belongs to the alkaline phosphatase family
DGN21_13125	COG0037	tRNA processing
DGN21_13130	COG1722	exodeoxyribonuclease VII activity
DGN21_13135	COG0142	geranyltranstransferase activity
DGN21_13140	COG4104	PAAR repeat-containing protein
DGN21_13150	COG0312	modulator of DNA gyrase
DGN21_13160	COG0312	modulator of DNA gyrase
DGN21_13170	COG3164	Protein of unknown function
DGN21_13180	COG0424	maF-like protein
DGN21_13185	COG2968	Membrane
DGN21_13195	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DGN21_13215	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DGN21_13230	COG0495	leucyl-tRNA aminoacylation
DGN21_13240	COG3118	belongs to the thioredoxin family
DGN21_13250	COG2155	Conserved Protein
DGN21_13300	COG1132	(ABC) transporter
DGN21_13330	COG0745	RESPONSE REGULATOR receiver
DGN21_13335	COG5002	protein histidine kinase activity
DGN21_13335	COG5000	phosphorelay sensor kinase activity
DGN21_13340	COG0475	glutathione-regulated potassium exporter activity
DGN21_13350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGN21_13370	COG1187	pseudouridine synthase activity
DGN21_13375	COG5002	protein histidine kinase activity
DGN21_13375	COG5001	Diguanylate cyclase
DGN21_13485	COG0667	Aldo Keto reductase
DGN21_13490	COG2814	Major facilitator Superfamily
DGN21_13495	COG0583	DNA-binding transcription factor activity
DGN21_13515	COG2207	Transcriptional regulator
DGN21_13530	COG1309	transcriptional regulator
DGN21_13540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN21_13555	COG0430	RNA-3'-phosphate cyclase activity
DGN21_13560	COG1690	Belongs to the RtcB family
DGN21_13570	COG4650	regulator
DGN21_13575	COG0735	belongs to the Fur family
DGN21_13580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGN21_13605	COG4452	Inner membrane protein CreD
DGN21_13615	COG2205	protein histidine kinase activity
DGN21_13620	COG0745	RESPONSE REGULATOR receiver
DGN21_13625	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DGN21_13640	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DGN21_13660	COG0840	transmembrane signaling receptor activity
DGN21_13665	COG0835	chemotaxis
DGN21_13670	COG2199	diguanylate cyclase activity
DGN21_13670	COG2200	EAL domain
DGN21_13670	COG2202	Pas domain
DGN21_13675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DGN21_13685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN21_13690	COG3590	peptidase
DGN21_13700	COG0588	phosphoglycerate mutase activity
DGN21_13705	COG1515	deoxyribonuclease V activity
DGN21_13710	COG1741	Belongs to the pirin family
DGN21_13725	COG1741	Belongs to the pirin family
DGN21_13730	COG1966	Carbon starvation protein
DGN21_13735	COG2879	small protein
DGN21_13740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DGN21_13775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DGN21_13780	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DGN21_13785	COG2080	2 iron, 2 sulfur cluster binding
DGN21_13795	COG5001	Diguanylate cyclase
DGN21_13795	COG4251	negative regulation of phosphorylation
DGN21_13795	COG3706	GGDEF domain
DGN21_13795	COG2203	Gaf domain
DGN21_13800	COG0629	single-stranded DNA binding
DGN21_13805	COG0142	geranyltranstransferase activity
DGN21_13830	COG0527	aspartate kinase activity
DGN21_13835	COG0384	phenazine biosynthesis protein PhzF
DGN21_13840	COG0384	phenazine biosynthesis protein PhzF
DGN21_13850	COG1764	response to oxidative stress
DGN21_13860	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DGN21_13865	COG1678	Uncharacterized ACR, COG1678
DGN21_13870	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DGN21_13875	COG0519	Catalyzes the synthesis of GMP from XMP
DGN21_13895	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DGN21_13910	COG4942	peptidase
DGN21_13930	COG0693	protein deglycase activity
DGN21_13940	COG1959	2 iron, 2 sulfur cluster binding
DGN21_13945	COG0719	Fe-S assembly protein
DGN21_13950	COG0396	ATPase activity
DGN21_13955	COG0719	Fe-S assembly protein
DGN21_13960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DGN21_13970	COG2146	nitrite reductase [NAD(P)H] activity
DGN21_13975	COG4774	siderophore transport
DGN21_13980	COG3128	pkhd-type hydroxylase
DGN21_14005	COG1477	protein flavinylation
DGN21_14010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGN21_14025	COG1555	photosystem II stabilization
DGN21_14030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DGN21_14040	COG3178	'Phosphotransferase
DGN21_14045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DGN21_14060	COG0628	permease
DGN21_14080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DGN21_14105	COG0271	Belongs to the BolA IbaG family
DGN21_14115	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DGN21_14125	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DGN21_14130	COG1137	ATPase activity
DGN21_14145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN21_14165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DGN21_14170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGN21_14175	COG2239	Acts as a magnesium transporter
DGN21_14185	COG1294	oxidase, subunit
DGN21_14190	COG1271	oxidase subunit
DGN21_14205	COG1113	amino acid transport
DGN21_14220	COG2197	response regulator
DGN21_14225	COG0531	amino acid
DGN21_14280	COG2814	Major facilitator Superfamily
DGN21_14290	COG0754	glutathionylspermidine amidase activity
DGN21_14315	COG1842	Phage shock protein A
DGN21_14335	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DGN21_14340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DGN21_14350	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DGN21_14425	COG0477	Major facilitator Superfamily
DGN21_14440	COG2353	YceI-like domain
DGN21_14445	COG3038	cytochrome b561
DGN21_14455	COG1278	Cold shock
DGN21_14465	COG1760	l-serine dehydratase
DGN21_14475	COG0460	homoserine dehydrogenase
DGN21_14475	COG0527	aspartate kinase activity
DGN21_14480	COG0626	cystathionine gamma-synthase activity
DGN21_14485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGN21_14490	COG0739	heme binding
DGN21_14495	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DGN21_14500	COG1272	protein, Hemolysin III
DGN21_14505	COG2982	Protein involved in outer membrane biogenesis
DGN21_14510	COG0516	GMP reductase activity
DGN21_14510	COG0517	IMP dehydrogenase activity
DGN21_14515	COG0463	Glycosyl transferase, family 2
DGN21_14520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGN21_14525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DGN21_14540	COG1309	transcriptional regulator
DGN21_14550	COG1960	acyl-CoA dehydrogenase activity
DGN21_14580	COG0509	glycine decarboxylation via glycine cleavage system
DGN21_14585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DGN21_14595	COG0330	HflC and HflK could
DGN21_14600	COG1742	UPF0060 membrane protein
DGN21_14605	COG3956	TIGRFAM MazG family protein
DGN21_14615	COG0494	nUDIX hydrolase
DGN21_14625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DGN21_14630	COG0837	glucose binding
DGN21_14645	COG1388	LysM domain
DGN21_14645	COG3858	chitin binding
DGN21_14660	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN21_14675	COG3537	Alpha-1,2-mannosidase
DGN21_14720	COG1446	asparaginase
DGN21_14725	COG2304	oxidoreductase activity
DGN21_14730	COG1595	DNA-templated transcription, initiation
DGN21_14755	COG2198	Histidine kinase
DGN21_14755	COG0784	Response regulator, receiver
DGN21_14755	COG0643	Histidine kinase
DGN21_14760	COG0840	transmembrane signaling receptor activity
DGN21_14765	COG0835	chemotaxis
DGN21_14780	COG0189	ligase activity
DGN21_14790	COG1397	ADP-ribosylglycohydrolase
DGN21_14800	COG1199	ATP-dependent helicase activity
DGN21_14810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DGN21_14815	COG1215	transferase activity, transferring glycosyl groups
DGN21_14830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGN21_14840	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DGN21_14845	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DGN21_14855	COG0535	radical SAM domain protein
DGN21_14870	COG0837	glucose binding
DGN21_14880	COG1643	Atp-dependent helicase
DGN21_14885	COG0783	Belongs to the Dps family
DGN21_14895	COG0514	ATP-dependent DNA helicase (RecQ)
DGN21_14920	COG1187	pseudouridine synthase activity
DGN21_14930	COG0840	transmembrane signaling receptor activity
DGN21_14955	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DGN21_14975	COG0667	Aldo Keto reductase
DGN21_14980	COG0602	queuosine metabolic process
DGN21_14990	COG2885	chlorophyll binding
DGN21_14995	COG0823	Involved in the tonB-independent uptake of proteins
DGN21_15005	COG0848	biopolymer transport protein
DGN21_15015	COG0824	Thioesterase
DGN21_15020	COG2255	four-way junction helicase activity
DGN21_15080	COG0477	Major facilitator Superfamily
DGN21_15115	COG0488	(ABC) transporter
DGN21_15150	COG4651	solute:proton antiporter activity
DGN21_15150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGN21_15160	COG4772	TonB-dependent receptor
DGN21_15170	COG4264	IucA IucC family
DGN21_15175	COG2814	Major facilitator Superfamily
DGN21_15180	COG4264	IucA IucC family
DGN21_15185	COG0019	diaminopimelate decarboxylase activity
DGN21_15200	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DGN21_15210	COG4206	TonB-dependent receptor
DGN21_15225	COG0542	response to heat
DGN21_15230	COG1116	anion transmembrane transporter activity
DGN21_15235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DGN21_15240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DGN21_15245	COG0667	Aldo Keto reductase
DGN21_15250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DGN21_15255	COG4771	TonB-dependent receptor
DGN21_15305	COG1877	trehalose-phosphatase activity
DGN21_15310	COG3387	PFAM Glycoside hydrolase 15-related
DGN21_15325	COG0840	transmembrane signaling receptor activity
DGN21_15335	COG3011	Protein conserved in bacteria
DGN21_15345	COG1496	oxidoreductase activity
DGN21_15350	COG0564	pseudouridine synthase activity
DGN21_15355	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN21_15365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGN21_15365	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DGN21_15390	COG0045	succinate-CoA ligase (ADP-forming) activity
DGN21_15410	COG4969	Belongs to the N-Me-Phe pilin family
DGN21_15425	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DGN21_15445	COG0745	RESPONSE REGULATOR receiver
DGN21_15455	COG0189	ligase activity
DGN21_15495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DGN21_15500	COG3273	potassium ion transport
DGN21_15500	COG0471	metal ion transport
DGN21_15520	COG1970	mechanosensitive ion channel activity
DGN21_15530	COG1609	Transcriptional regulator
DGN21_15540	COG3250	beta-galactosidase activity
DGN21_15545	COG4948	Mandelate Racemase Muconate Lactonizing
DGN21_15550	COG2272	Belongs to the type-B carboxylesterase lipase family
DGN21_15555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DGN21_15570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN21_15575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN21_15580	COG0529	Catalyzes the synthesis of activated sulfate
DGN21_15580	COG2895	sulfate adenylyltransferase (ATP) activity
DGN21_15590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DGN21_15595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DGN21_15600	COG0175	sulfate reduction
DGN21_15620	COG2205	protein histidine kinase activity
DGN21_15620	COG2198	Histidine kinase
DGN21_15620	COG0784	Response regulator, receiver
DGN21_15635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DGN21_15635	COG1648	precorrin-2 dehydrogenase activity
DGN21_15650	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DGN21_15655	COG3588	fructose-bisphosphate aldolase
DGN21_15660	COG0469	pyruvate kinase activity
DGN21_15685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DGN21_15705	COG3047	cAMP biosynthetic process
DGN21_15715	COG3453	Protein conserved in bacteria
DGN21_15715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGN21_15720	COG0725	ABC transporter, periplasmic molybdate-binding protein
DGN21_15725	COG4149	molybdate abc transporter
DGN21_15760	COG0642	Histidine kinase
DGN21_15775	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_15785	COG1022	Amp-dependent synthetase and ligase
DGN21_15810	COG1376	ErfK ybiS ycfS ynhG family protein
DGN21_15815	COG0739	heme binding
DGN21_15820	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_15825	COG0583	DNA-binding transcription factor activity
DGN21_15830	COG4773	Receptor
DGN21_15835	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DGN21_15840	COG1301	dicarboxylic acid transport
DGN21_15870	COG0714	Associated with various cellular activities
DGN21_15900	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DGN21_15925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DGN21_15935	COG2721	sulfolactate sulfo-lyase activity
DGN21_15950	COG2271	Major facilitator Superfamily
DGN21_15965	COG0583	DNA-binding transcription factor activity
DGN21_15970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGN21_15985	COG1561	YicC-like family, N-terminal region
DGN21_15990	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DGN21_16005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DGN21_16020	COG0006	proline dipeptidase activity
DGN21_16030	COG0006	proline dipeptidase activity
DGN21_16055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DGN21_16075	COG2912	Transglutaminase-like superfamily
DGN21_16080	COG1773	rubredoxin
DGN21_16085	COG0352	thiamine-phosphate diphosphorylase activity
DGN21_16105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DGN21_16120	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
DGN21_16125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGN21_16155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DGN21_16160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DGN21_16175	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_16185	COG0671	phosphoesterase, PA-phosphatase related
DGN21_16190	COG3781	membrane
DGN21_16200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DGN21_16205	COG0563	adenylate kinase activity
DGN21_16220	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DGN21_16230	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DGN21_16250	COG3710	Transcriptional regulator
DGN21_16255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DGN21_16270	COG0823	Involved in the tonB-independent uptake of proteins
DGN21_16270	COG1506	peptidase
DGN21_16270	COG4946	Tricorn protease homolog
DGN21_16275	COG0840	transmembrane signaling receptor activity
DGN21_16280	COG0405	Gamma-glutamyltransferase
DGN21_16285	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DGN21_16305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DGN21_16315	COG0473	3-isopropylmalate dehydrogenase activity
DGN21_16320	COG0066	3-isopropylmalate dehydratase activity
DGN21_16325	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DGN21_16345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DGN21_16350	COG1538	Outer membrane efflux protein
DGN21_16365	COG1519	Transferase
DGN21_16370	COG1560	Kdo2-lipid A biosynthetic process
DGN21_16395	COG0281	malic enzyme
DGN21_16395	COG0280	phosphate acetyltransferase
DGN21_16410	COG4191	Histidine kinase
DGN21_16425	COG0583	DNA-binding transcription factor activity
DGN21_16440	COG0667	Aldo Keto reductase
DGN21_16445	COG2197	response regulator
DGN21_16455	COG0642	Histidine kinase
DGN21_16470	COG2851	Citrate transporter
DGN21_16475	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_16480	COG1609	Transcriptional regulator
DGN21_16485	COG2211	Major facilitator Superfamily
DGN21_16565	COG4773	Receptor
DGN21_16570	COG0726	polysaccharide deacetylase
DGN21_16575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DGN21_16590	COG3964	amidohydrolase
DGN21_16595	COG1228	amidohydrolase
DGN21_16620	COG1307	EDD domain protein, DegV family
DGN21_16635	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DGN21_16640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGN21_16665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGN21_16665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGN21_16680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DGN21_16690	COG0488	(ABC) transporter
DGN21_16695	COG0242	peptide deformylase activity
DGN21_16715	COG0457	Tetratricopeptide repeat
DGN21_16720	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DGN21_16725	COG1215	transferase activity, transferring glycosyl groups
DGN21_16730	COG1215	transferase activity, transferring glycosyl groups
DGN21_16790	COG2188	Transcriptional regulator
DGN21_16800	COG1450	Type ii and iii secretion system protein
DGN21_16815	COG3166	PFAM Fimbrial assembly family protein
DGN21_16820	COG3156	type II secretion system protein K
DGN21_16825	COG4795	General secretion pathway protein
DGN21_16830	COG2165	general secretion pathway protein
DGN21_16835	COG4970	Tfp pilus assembly protein FimT
DGN21_16840	COG2165	general secretion pathway protein
DGN21_16845	COG1459	type II secretion system
DGN21_16850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGN21_16855	COG1404	Belongs to the peptidase S8 family
DGN21_16860	COG5295	Hep Hag repeat protein
DGN21_16865	COG1404	Belongs to the peptidase S8 family
DGN21_16875	COG0047	phosphoribosylformylglycinamidine synthase activity
DGN21_16875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DGN21_16885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DGN21_16890	COG4974	Belongs to the 'phage' integrase family
DGN21_16900	COG0795	lipopolysaccharide-transporting ATPase activity
DGN21_16910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGN21_16945	COG1183	phosphatidylcholine synthase activity
DGN21_16955	COG0442	prolyl-tRNA aminoacylation
DGN21_16970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGN21_16975	COG1127	ABC transporter
DGN21_16980	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGN21_16980	COG3218	ABC-type transport auxiliary lipoprotein component
DGN21_17010	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DGN21_17015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGN21_17045	COG2086	electron transfer activity
DGN21_17070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DGN21_17080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGN21_17085	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DGN21_17100	COG0438	transferase activity, transferring glycosyl groups
DGN21_17125	COG0626	cystathionine gamma-synthase activity
DGN21_17155	COG0625	glutathione transferase activity
DGN21_17170	COG0513	Belongs to the DEAD box helicase family
DGN21_17180	COG4771	TonB-dependent receptor
DGN21_17185	COG0720	synthase
DGN21_17195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DGN21_17200	COG1956	GAF domain-containing protein
DGN21_17210	COG2819	hydrolase of the alpha beta superfamily
DGN21_17220	COG0546	phosphoglycolate phosphatase activity
DGN21_17225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DGN21_17245	COG0339	signal peptide processing
DGN21_17290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGN21_17295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN21_17300	COG1136	(ABC) transporter
DGN21_17305	COG0577	efflux transmembrane transporter activity
DGN21_17305	COG1136	(ABC) transporter
DGN21_17325	COG4191	Histidine kinase
DGN21_17335	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DGN21_17350	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DGN21_17370	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DGN21_17375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DGN21_17385	COG0356	it plays a direct role in the translocation of protons across the membrane
DGN21_17400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGN21_17410	COG0508	dehydrogenase complex catalyzes the overall conversion of
DGN21_17445	COG2011	ABC-type metal ion transport system permease component
DGN21_17450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DGN21_17455	COG0697	spore germination
DGN21_17460	COG1666	GTP binding
DGN21_17470	COG0784	Response regulator, receiver
DGN21_17470	COG2198	Histidine kinase
DGN21_17470	COG5002	protein histidine kinase activity
DGN21_17490	COG1187	pseudouridine synthase activity
DGN21_17515	COG2202	Pas domain
DGN21_17515	COG2205	protein histidine kinase activity
DGN21_17535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DGN21_17540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DGN21_17590	COG0842	Transport permease protein
DGN21_17595	COG1131	(ABC) transporter
DGN21_17600	COG0025	NhaP-type Na H and K H
DGN21_17615	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DGN21_17620	COG1573	uracil-dna glycosylase
DGN21_17630	COG3384	dioxygenase
DGN21_17640	COG0583	DNA-binding transcription factor activity
DGN21_17650	COG0667	Aldo Keto reductase
DGN21_17660	COG3590	peptidase
DGN21_17675	COG0531	amino acid
DGN21_17690	COG2972	Histidine kinase
DGN21_17705	COG3685	Protein conserved in bacteria
DGN21_17710	COG3546	catalase activity
DGN21_17735	COG2204	response regulator
DGN21_17745	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_17760	COG1063	alcohol dehydrogenase
DGN21_17785	COG0583	DNA-binding transcription factor activity
DGN21_17790	COG2814	Major facilitator Superfamily
DGN21_17825	COG1131	(ABC) transporter
DGN21_17840	COG0251	oxidation-reduction process
DGN21_17855	COG0840	transmembrane signaling receptor activity
DGN21_17890	COG0659	secondary active sulfate transmembrane transporter activity
DGN21_17895	COG0038	chloride channel
DGN21_17900	COG0024	Methionine aminopeptidase
DGN21_17915	COG1309	transcriptional regulator
DGN21_17930	COG0431	NADPH-dependent FMN reductase
DGN21_17935	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DGN21_17970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGN21_17975	COG1490	D-aminoacyl-tRNA deacylase activity
DGN21_17980	COG1560	Kdo2-lipid A biosynthetic process
DGN21_17990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DGN21_18025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DGN21_18025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DGN21_18035	COG0242	peptide deformylase activity
DGN21_18040	COG1652	LysM domain
DGN21_18045	COG0758	DNA mediated transformation
DGN21_18065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGN21_18065	COG1754	DNA topoisomerase type I activity
DGN21_18070	COG0009	L-threonylcarbamoyladenylate synthase
DGN21_18085	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_18095	COG0616	signal peptide processing
DGN21_18100	COG0534	Mate efflux family protein
DGN21_18115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DGN21_18120	COG0625	glutathione transferase activity
DGN21_18135	COG1252	NADH dehydrogenase
DGN21_18140	COG2860	membrane
DGN21_18145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DGN21_18150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DGN21_18155	COG3437	response regulator, receiver
DGN21_18160	COG2177	Part of the ABC transporter FtsEX involved in
DGN21_18165	COG2884	Cell division ATP-binding protein ftsE
DGN21_18175	COG3118	belongs to the thioredoxin family
DGN21_18180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DGN21_18190	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DGN21_18210	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGN21_18210	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DGN21_18215	COG1473	amidohydrolase
DGN21_18225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGN21_18235	COG5383	Protein conserved in bacteria
DGN21_18285	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DGN21_18290	COG3023	N-Acetylmuramoyl-L-alanine amidase
DGN21_18300	COG4948	Mandelate Racemase Muconate Lactonizing
DGN21_18310	COG0531	amino acid
DGN21_18325	COG4682	membrane
DGN21_18330	COG2133	pyrroloquinoline quinone binding
DGN21_18340	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DGN21_18355	COG1610	YqeY-like protein
DGN21_18360	COG1295	ribonuclease BN
DGN21_18365	COG0358	DNA primase activity
DGN21_18385	COG0109	protoheme IX farnesyltransferase activity
DGN21_18415	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DGN21_18430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DGN21_18475	COG0739	heme binding
DGN21_18490	COG2211	Major facilitator Superfamily
DGN21_18495	COG0708	Exodeoxyribonuclease III
DGN21_18510	COG1192	Involved in chromosome partitioning
DGN21_18515	COG1475	DNA binding
DGN21_18535	COG0463	Glycosyl transferase, family 2
DGN21_18560	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DGN21_18570	COG0018	arginyl-trna synthetase
DGN21_18585	COG4221	oxidoreductase activity
DGN21_18590	COG2755	lipolytic protein G-D-S-L family
DGN21_18590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DGN21_18600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN21_18600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DGN21_18605	COG1166	arginine decarboxylase activity
DGN21_18610	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DGN21_18645	COG0606	chelatase, subunit chli
DGN21_18670	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DGN21_18725	COG1090	epimerase
DGN21_18735	COG0642	Histidine kinase
DGN21_18775	COG0628	permease
DGN21_18780	COG1011	Hydrolase
DGN21_18785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGN21_18815	COG2197	response regulator
DGN21_18820	COG4585	Histidine kinase
DGN21_18825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN21_18830	COG1136	(ABC) transporter
DGN21_18855	COG0697	spore germination
DGN21_18880	COG0180	Tryptophanyl-tRNA synthetase
DGN21_18885	COG3237	CsbD-like
DGN21_18930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DGN21_18945	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DGN21_18950	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DGN21_18950	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DGN21_18990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DGN21_19015	COG1199	ATP-dependent helicase activity
DGN21_19105	COG0625	glutathione transferase activity
DGN21_19140	COG4555	ABC transporter
DGN21_19150	COG1476	TRANSCRIPTIONal
DGN21_19185	COG1131	(ABC) transporter
DGN21_19190	COG0842	Transport permease protein
DGN21_19195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DGN21_19205	COG1607	acyl-coa hydrolase
DGN21_19225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGN21_19230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DGN21_19245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DGN21_19245	COG1042	CoA-binding domain protein
DGN21_19245	COG0045	succinate-CoA ligase (ADP-forming) activity
DGN21_19250	COG2239	Acts as a magnesium transporter
DGN21_19270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DGN21_19275	COG3387	PFAM Glycoside hydrolase 15-related
DGN21_19290	COG3100	YcgL domain-containing protein
DGN21_19295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DGN21_19315	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_19345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DGN21_19360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DGN21_19440	COG3621	Patatin-like phospholipase
DGN21_19460	COG0210	DNA helicase
DGN21_19475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN21_19480	COG0583	DNA-binding transcription factor activity
DGN21_19485	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DGN21_19495	COG2159	amidohydrolase
DGN21_19515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DGN21_19540	COG0357	Ribosomal RNA small subunit methyltransferase G
DGN21_19545	COG3540	Alkaline phosphatase
DGN21_19555	COG2091	lysine biosynthetic process via aminoadipic acid
DGN21_19580	COG1940	carbohydrate kinase activity
DGN21_19590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGN21_19605	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DGN21_19610	COG3162	membrane
DGN21_19655	COG3507	Belongs to the glycosyl hydrolase 43 family
DGN21_19670	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_19675	COG0179	Fumarylacetoacetate (FAA) hydrolase
DGN21_19680	COG4948	Mandelate Racemase Muconate Lactonizing
DGN21_19685	COG3254	rhamnose metabolic process
DGN21_19690	COG0738	Major facilitator superfamily
DGN21_19695	COG1414	Transcriptional regulator
DGN21_19700	COG1971	Probably functions as a manganese efflux pump
DGN21_19705	COG0784	Response regulator, receiver
DGN21_19705	COG2205	protein histidine kinase activity
DGN21_19710	COG3459	Glycosyltransferase 36 associated
DGN21_19715	COG2211	Major facilitator Superfamily
DGN21_19720	COG3265	gluconokinase activity
DGN21_19730	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DGN21_19750	COG2911	Protein conserved in bacteria
DGN21_19755	COG0729	surface antigen
DGN21_19760	COG4771	TonB-dependent receptor
DGN21_19765	COG0457	Tetratricopeptide repeat
DGN21_19780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGN21_19785	COG0519	Catalyzes the synthesis of GMP from XMP
DGN21_19785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DGN21_19795	COG0805	protein transport
DGN21_19800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGN21_19805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGN21_19815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DGN21_19835	COG2974	May be involved in recombination
DGN21_19840	COG0037	tRNA processing
DGN21_19850	COG2115	Belongs to the xylose isomerase family
DGN21_19860	COG3661	Belongs to the glycosyl hydrolase 67 family
DGN21_19870	COG4948	Mandelate Racemase Muconate Lactonizing
DGN21_19880	COG1472	Belongs to the glycosyl hydrolase 3 family
DGN21_19885	COG0246	Mannitol dehydrogenase
DGN21_19900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DGN21_19935	COG3386	PFAM SMP-30 Gluconolaconase
DGN21_19945	COG3250	beta-galactosidase activity
DGN21_19950	COG1904	glucuronate isomerase
DGN21_19955	COG3693	PFAM glycoside hydrolase, family 10
DGN21_19970	COG2211	Major facilitator Superfamily
DGN21_20015	COG1028	Short-chain dehydrogenase reductase Sdr
DGN21_20015	COG3321	synthase
DGN21_20015	COG0604	alcohol dehydrogenase
DGN21_20020	COG2937	Belongs to the GPAT DAPAT family
DGN21_20055	COG0284	orotidine-5'-phosphate decarboxylase activity
DGN21_20060	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DGN21_20065	COG3132	Protein of unknown function, DUF480
DGN21_20075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DGN21_20130	COG0210	DNA helicase
DGN21_20135	COG1435	thymidine kinase activity
DGN21_20145	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DGN21_20155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DGN21_20190	COG3135	benzoate transporter
DGN21_20215	COG0676	glucose-6-phosphate 1-epimerase activity
DGN21_20230	COG0730	response to heat
DGN21_20250	COG0302	gtp cyclohydrolase
DGN21_20265	COG1566	PFAM secretion protein HlyD family protein
DGN21_20275	COG1289	transmembrane transporter activity
DGN21_20280	COG0477	Major facilitator Superfamily
DGN21_20295	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DGN21_20300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DGN21_20355	COG0564	pseudouridine synthase activity
DGN21_20410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DGN21_20420	COG1074	ATP-dependent DNA helicase activity
DGN21_20425	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DGN21_20460	COG1127	ABC transporter
DGN21_20465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DGN21_20470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DGN21_20485	COG2853	Lipoprotein
DGN21_20490	COG0386	Belongs to the glutathione peroxidase family
DGN21_20500	COG1322	Protein conserved in bacteria
DGN21_20510	COG0531	amino acid
DGN21_20515	COG3537	Alpha-1,2-mannosidase
DGN21_20530	COG3706	GGDEF domain
DGN21_20535	COG3835	regulator
DGN21_20540	COG1929	Belongs to the glycerate kinase type-1 family
DGN21_20545	COG2271	Major facilitator Superfamily
DGN21_20560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DGN21_20570	COG0861	Integral membrane protein TerC family
DGN21_20585	COG0584	glycerophosphoryl diester phosphodiesterase
DGN21_20595	COG0671	phosphoesterase, PA-phosphatase related
DGN21_20605	COG0726	polysaccharide deacetylase
DGN21_20610	COG0706	membrane insertase activity