locus-tag	class	description
HEP75_00002	COG0592	DNA-directed DNA polymerase activity
HEP75_00003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP75_00004	COG0187	DNA topoisomerase II activity
HEP75_00005	COG1266	CAAX protease self-immunity
HEP75_00006	COG0501	Belongs to the peptidase M48B family
HEP75_00016	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP75_00022	COG1280	lysine exporter protein (LysE YggA)
HEP75_00027	COG4772	TonB-dependent receptor
HEP75_00031	COG3284	Transcriptional regulator
HEP75_00032	COG1012	belongs to the aldehyde dehydrogenase family
HEP75_00040	COG0277	FAD linked oxidase domain protein
HEP75_00042	COG2186	Transcriptional regulator
HEP75_00045	COG4585	Histidine kinase
HEP75_00046	COG2197	response regulator
HEP75_00056	COG2357	RelA SpoT domain protein
HEP75_00076	COG4771	TonB-dependent receptor
HEP75_00077	COG1629	transport
HEP75_00077	COG4774	siderophore transport
HEP75_00086	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HEP75_00089	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP75_00090	COG1609	Transcriptional regulator
HEP75_00092	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_00094	COG2755	lipolytic protein G-D-S-L family
HEP75_00096	COG3186	Phenylalanine-4-hydroxylase
HEP75_00097	COG1522	sequence-specific DNA binding
HEP75_00100	COG1752	Esterase of the alpha-beta hydrolase superfamily
HEP75_00102	COG1595	DNA-templated transcription, initiation
HEP75_00104	COG3220	belongs to the UPF0276 family
HEP75_00114	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HEP75_00121	COG1929	Belongs to the glycerate kinase type-1 family
HEP75_00123	COG2814	Major facilitator Superfamily
HEP75_00127	COG0531	amino acid
HEP75_00128	COG4566	intracellular signal transduction
HEP75_00129	COG4191	Histidine kinase
HEP75_00133	COG0625	glutathione transferase activity
HEP75_00134	COG1322	Protein conserved in bacteria
HEP75_00136	COG0386	Belongs to the glutathione peroxidase family
HEP75_00137	COG2853	Lipoprotein
HEP75_00140	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEP75_00141	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEP75_00142	COG1127	ABC transporter
HEP75_00149	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HEP75_00150	COG1074	ATP-dependent DNA helicase activity
HEP75_00151	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEP75_00157	COG0537	adenosine 5'-monophosphoramidase activity
HEP75_00168	COG0477	Major facilitator Superfamily
HEP75_00169	COG0302	gtp cyclohydrolase
HEP75_00174	COG0730	response to heat
HEP75_00177	COG2951	lytic endotransglycosylase activity
HEP75_00181	COG3135	benzoate transporter
HEP75_00188	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP75_00189	COG1803	Methylglyoxal synthase
HEP75_00190	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP75_00191	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP75_00192	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP75_00193	COG0493	'glutamate synthase
HEP75_00194	COG0067	glutamate synthase
HEP75_00194	COG0069	glutamate synthase activity
HEP75_00194	COG0070	glutamate synthase
HEP75_00199	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_00206	COG1205	dead DEAH box helicase
HEP75_00206	COG1111	helicase
HEP75_00207	COG3549	Plasmid maintenance system killer
HEP75_00218	COG2271	Major facilitator Superfamily
HEP75_00220	COG0657	acetylesterase activity
HEP75_00232	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP75_00233	COG1192	Involved in chromosome partitioning
HEP75_00236	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP75_00237	COG2050	protein possibly involved in aromatic compounds catabolism
HEP75_00241	COG1881	PFAM PEBP family protein
HEP75_00243	COG0174	glutamine synthetase
HEP75_00244	COG0347	Belongs to the P(II) protein family
HEP75_00245	COG0004	ammonium transporteR
HEP75_00246	COG3852	Histidine kinase
HEP75_00247	COG2204	response regulator
HEP75_00248	COG2032	superoxide dismutase activity
HEP75_00249	COG2032	superoxide dismutase activity
HEP75_00251	COG0183	Belongs to the thiolase family
HEP75_00260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP75_00264	COG0702	epimerase
HEP75_00265	COG0583	DNA-binding transcription factor activity
HEP75_00268	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HEP75_00270	COG0612	Peptidase, M16
HEP75_00272	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP75_00274	COG0596	Alpha beta hydrolase
HEP75_00276	COG0727	PFAM Uncharacterised protein family (UPF0153)
HEP75_00277	COG0318	PFAM AMP-dependent synthetase and ligase
HEP75_00280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP75_00286	COG0564	pseudouridine synthase activity
HEP75_00292	COG1595	DNA-templated transcription, initiation
HEP75_00293	COG1446	asparaginase
HEP75_00294	COG0339	signal peptide processing
HEP75_00295	COG0681	Belongs to the peptidase S26 family
HEP75_00300	COG0583	DNA-binding transcription factor activity
HEP75_00301	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HEP75_00302	COG2224	Isocitrate lyase
HEP75_00309	COG0659	secondary active sulfate transmembrane transporter activity
HEP75_00316	COG0583	DNA-binding transcription factor activity
HEP75_00317	COG1959	2 iron, 2 sulfur cluster binding
HEP75_00319	COG1690	Belongs to the RtcB family
HEP75_00322	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP75_00323	COG2130	NADP-dependent
HEP75_00326	COG1187	pseudouridine synthase activity
HEP75_00328	COG1643	Atp-dependent helicase
HEP75_00329	COG0084	hydrolase, TatD family'
HEP75_00350	COG0842	Transport permease protein
HEP75_00351	COG1131	(ABC) transporter
HEP75_00352	COG0543	2 iron, 2 sulfur cluster binding
HEP75_00352	COG0633	Ferredoxin
HEP75_00353	COG0662	Cupin 2, conserved barrel domain protein
HEP75_00353	COG2207	Transcriptional regulator
HEP75_00356	COG1476	TRANSCRIPTIONal
HEP75_00358	COG4555	ABC transporter
HEP75_00362	COG0625	glutathione transferase activity
HEP75_00369	COG0028	Belongs to the TPP enzyme family
HEP75_00375	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP75_00379	COG1199	ATP-dependent helicase activity
HEP75_00391	COG0628	permease
HEP75_00396	COG2133	pyrroloquinoline quinone binding
HEP75_00406	COG0754	glutathionylspermidine amidase activity
HEP75_00416	COG2831	hemolysin activation secretion protein
HEP75_00418	COG0714	Associated with various cellular activities
HEP75_00424	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEP75_00427	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_00428	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP75_00433	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEP75_00437	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_00442	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HEP75_00444	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP75_00448	COG0606	chelatase, subunit chli
HEP75_00449	COG2960	long-chain fatty acid transporting porin activity
HEP75_00454	COG1166	arginine decarboxylase activity
HEP75_00455	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP75_00455	COG2755	lipolytic protein G-D-S-L family
HEP75_00456	COG0583	DNA-binding transcription factor activity
HEP75_00460	COG4221	oxidoreductase activity
HEP75_00464	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEP75_00466	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP75_00468	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEP75_00470	COG2814	Major facilitator Superfamily
HEP75_00472	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HEP75_00473	COG0739	heme binding
HEP75_00474	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEP75_00480	COG1064	alcohol dehydrogenase
HEP75_00481	COG2234	aminopeptidase activity
HEP75_00483	COG4942	peptidase
HEP75_00484	COG0793	Belongs to the peptidase S41A family
HEP75_00490	COG0531	amino acid
HEP75_00492	COG1486	melibiose metabolic process
HEP75_00495	COG1565	acr, cog1565
HEP75_00495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEP75_00496	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP75_00498	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HEP75_00499	COG1845	cytochrome c oxidase, subunit III
HEP75_00503	COG1612	heme a metabolic process
HEP75_00504	COG0109	protoheme IX farnesyltransferase activity
HEP75_00509	COG1295	ribonuclease BN
HEP75_00510	COG1610	YqeY-like protein
HEP75_00513	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEP75_00514	COG2308	Evidence 4 Homologs of previously reported genes of
HEP75_00517	COG2133	pyrroloquinoline quinone binding
HEP75_00521	COG0531	amino acid
HEP75_00524	COG4948	Mandelate Racemase Muconate Lactonizing
HEP75_00526	COG4771	TonB-dependent receptor
HEP75_00527	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP75_00533	COG3409	Peptidoglycan-binding domain 1 protein
HEP75_00533	COG3501	Rhs element vgr protein
HEP75_00535	COG0477	Major facilitator Superfamily
HEP75_00543	COG5383	Protein conserved in bacteria
HEP75_00547	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_00550	COG1652	LysM domain
HEP75_00556	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HEP75_00557	COG3118	belongs to the thioredoxin family
HEP75_00559	COG2884	Cell division ATP-binding protein ftsE
HEP75_00560	COG2177	Part of the ABC transporter FtsEX involved in
HEP75_00561	COG2201	protein-glutamate methylesterase activity
HEP75_00563	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP75_00564	COG2860	membrane
HEP75_00565	COG1252	NADH dehydrogenase
HEP75_00567	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HEP75_00569	COG0534	Mate efflux family protein
HEP75_00570	COG0616	signal peptide processing
HEP75_00572	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_00575	COG0009	L-threonylcarbamoyladenylate synthase
HEP75_00576	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEP75_00576	COG1754	DNA topoisomerase type I activity
HEP75_00577	COG1714	RDD family
HEP75_00580	COG0758	DNA mediated transformation
HEP75_00581	COG1652	LysM domain
HEP75_00582	COG0242	peptide deformylase activity
HEP75_00584	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HEP75_00584	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP75_00585	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP75_00587	COG3307	-O-antigen
HEP75_00588	COG1215	transferase activity, transferring glycosyl groups
HEP75_00592	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP75_00593	COG1247	-acetyltransferase
HEP75_00595	COG1490	D-aminoacyl-tRNA deacylase activity
HEP75_00596	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP75_00599	COG1609	Transcriptional regulator
HEP75_00600	COG3537	Alpha-1,2-mannosidase
HEP75_00601	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_00603	COG0583	DNA-binding transcription factor activity
HEP75_00604	COG0366	Alpha amylase catalytic
HEP75_00605	COG0366	Alpha amylase catalytic
HEP75_00606	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP75_00623	COG4974	Belongs to the 'phage' integrase family
HEP75_00631	COG0443	Heat shock 70 kDa protein
HEP75_00635	COG0300	oxidoreductase activity
HEP75_00638	COG3550	peptidyl-serine autophosphorylation
HEP75_00641	COG0024	Methionine aminopeptidase
HEP75_00646	COG4773	Receptor
HEP75_00648	COG2207	Transcriptional regulator
HEP75_00650	COG1309	transcriptional regulator
HEP75_00654	COG2124	cytochrome p450
HEP75_00654	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP75_00655	COG1309	transcriptional regulator
HEP75_00657	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP75_00658	COG2271	Major facilitator Superfamily
HEP75_00663	COG0745	RESPONSE REGULATOR receiver
HEP75_00664	COG4932	domain protein
HEP75_00664	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HEP75_00664	COG3266	domain, Protein
HEP75_00668	COG0840	transmembrane signaling receptor activity
HEP75_00671	COG3546	catalase activity
HEP75_00672	COG3685	Protein conserved in bacteria
HEP75_00673	COG3685	Protein conserved in bacteria
HEP75_00674	COG0588	phosphoglycerate mutase activity
HEP75_00675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEP75_00676	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_00678	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP75_00685	COG0028	Belongs to the TPP enzyme family
HEP75_00686	COG4191	Histidine kinase
HEP75_00691	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP75_00691	COG1648	precorrin-2 dehydrogenase activity
HEP75_00693	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEP75_00693	COG1116	anion transmembrane transporter activity
HEP75_00695	COG2223	nitrite transmembrane transporter activity
HEP75_00696	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP75_00697	COG2146	nitrite reductase [NAD(P)H] activity
HEP75_00698	COG0243	molybdopterin cofactor binding
HEP75_00703	COG1640	4-alpha-glucanotransferase
HEP75_00704	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP75_00706	COG0297	glycogen (starch) synthase activity
HEP75_00708	COG0745	RESPONSE REGULATOR receiver
HEP75_00710	COG1335	isochorismatase
HEP75_00715	COG0181	hydroxymethylbilane synthase activity
HEP75_00718	COG1733	regulation of RNA biosynthetic process
HEP75_00721	COG1505	serine-type exopeptidase activity
HEP75_00722	COG0436	Aminotransferase
HEP75_00724	COG2832	Protein of unknown function (DUF454)
HEP75_00726	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HEP75_00731	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HEP75_00732	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HEP75_00733	COG0366	Alpha amylase catalytic
HEP75_00736	COG3345	alpha-galactosidase
HEP75_00738	COG2222	sugar isomerase
HEP75_00739	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
HEP75_00743	COG1349	DNA-binding transcription factor activity
HEP75_00756	COG3250	beta-galactosidase activity
HEP75_00759	COG2188	Transcriptional regulator
HEP75_00761	COG1609	Transcriptional regulator
HEP75_00762	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP75_00763	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEP75_00768	COG3250	beta-galactosidase activity
HEP75_00772	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP75_00775	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HEP75_00777	COG2207	Transcriptional regulator
HEP75_00781	COG3738	Protein conserved in bacteria
HEP75_00784	COG2205	protein histidine kinase activity
HEP75_00788	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEP75_00789	COG3791	Glutathione-dependent formaldehyde-activating
HEP75_00795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP75_00797	COG0697	spore germination
HEP75_00799	COG1307	EDD domain protein, DegV family
HEP75_00802	COG0804	urea catabolic process
HEP75_00803	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP75_00806	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEP75_00811	COG0436	Aminotransferase
HEP75_00815	COG1162	GTPase activity
HEP75_00820	COG2211	Major facilitator Superfamily
HEP75_00822	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_00823	COG2851	Citrate transporter
HEP75_00827	COG0642	Histidine kinase
HEP75_00829	COG2205	protein histidine kinase activity
HEP75_00829	COG0745	RESPONSE REGULATOR receiver
HEP75_00829	COG2205	protein histidine kinase activity
HEP75_00829	COG3292	Two component regulator propeller
HEP75_00829	COG0745	RESPONSE REGULATOR receiver
HEP75_00829	COG3292	Two component regulator propeller
HEP75_00832	COG4191	Histidine kinase
HEP75_00834	COG1301	dicarboxylic acid transport
HEP75_00835	COG0280	phosphate acetyltransferase
HEP75_00835	COG0281	malic enzyme
HEP75_00840	COG1560	Kdo2-lipid A biosynthetic process
HEP75_00841	COG1519	Transferase
HEP75_00842	COG1538	Outer membrane efflux protein
HEP75_00843	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP75_00846	COG0473	3-isopropylmalate dehydrogenase activity
HEP75_00847	COG0066	3-isopropylmalate dehydratase activity
HEP75_00850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEP75_00851	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP75_00855	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEP75_00857	COG2815	serine threonine protein kinase
HEP75_00857	COG0515	serine threonine protein kinase
HEP75_00858	COG0405	Gamma-glutamyltransferase
HEP75_00859	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HEP75_00860	COG0840	transmembrane signaling receptor activity
HEP75_00863	COG0823	Involved in the tonB-independent uptake of proteins
HEP75_00867	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HEP75_00869	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HEP75_00877	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEP75_00879	COG0671	phosphoesterase, PA-phosphatase related
HEP75_00882	COG1940	carbohydrate kinase activity
HEP75_00883	COG0346	lactoylglutathione lyase activity
HEP75_00884	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP75_00885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP75_00887	COG4206	TonB-dependent receptor
HEP75_00889	COG2010	Cytochrome c
HEP75_00891	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP75_00892	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HEP75_00893	COG2909	trisaccharide binding
HEP75_00894	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEP75_00898	COG1773	rubredoxin
HEP75_00903	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEP75_00908	COG3079	Belongs to the UPF0149 family
HEP75_00909	COG0006	proline dipeptidase activity
HEP75_00910	COG0006	proline dipeptidase activity
HEP75_00913	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEP75_00914	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEP75_00915	COG0346	lactoylglutathione lyase activity
HEP75_00916	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HEP75_00917	COG1561	YicC-like family, N-terminal region
HEP75_00918	COG0194	GDP metabolic process
HEP75_00919	COG1758	RNA polymerase activity
HEP75_00920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP75_00922	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEP75_00924	COG0254	rRNA binding
HEP75_00925	COG0372	Belongs to the citrate synthase family
HEP75_00928	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEP75_00934	COG0714	Associated with various cellular activities
HEP75_00941	COG1301	dicarboxylic acid transport
HEP75_00942	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEP75_00947	COG0739	heme binding
HEP75_00948	COG1376	ErfK ybiS ycfS ynhG family protein
HEP75_00956	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HEP75_00957	COG4149	molybdate abc transporter
HEP75_00958	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEP75_00960	COG0640	Transcriptional regulator
HEP75_00963	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP75_00964	COG3591	Belongs to the peptidase S1B family
HEP75_00970	COG3047	cAMP biosynthetic process
HEP75_00971	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEP75_00976	COG1902	pentaerythritol trinitrate reductase activity
HEP75_00977	COG0300	oxidoreductase activity
HEP75_00978	COG4221	oxidoreductase activity
HEP75_00980	COG0604	alcohol dehydrogenase
HEP75_00981	COG0840	transmembrane signaling receptor activity
HEP75_00986	COG0469	pyruvate kinase activity
HEP75_00987	COG3588	fructose-bisphosphate aldolase
HEP75_00989	COG2205	protein histidine kinase activity
HEP75_00992	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HEP75_01001	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HEP75_01006	COG2351	hydroxyisourate hydrolase activity
HEP75_01008	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP75_01014	COG2198	Histidine kinase
HEP75_01014	COG0784	Response regulator, receiver
HEP75_01014	COG2205	protein histidine kinase activity
HEP75_01015	COG0431	NADPH-dependent FMN reductase
HEP75_01016	COG1393	Belongs to the ArsC family
HEP75_01021	COG0175	sulfate reduction
HEP75_01022	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP75_01023	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP75_01025	COG2895	sulfate adenylyltransferase (ATP) activity
HEP75_01025	COG0529	Catalyzes the synthesis of activated sulfate
HEP75_01027	COG0438	transferase activity, transferring glycosyl groups
HEP75_01031	COG1115	amino acid carrier protein
HEP75_01033	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP75_01038	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP75_01041	COG3273	potassium ion transport
HEP75_01041	COG0471	metal ion transport
HEP75_01043	COG2022	thiamine diphosphate biosynthetic process
HEP75_01048	COG3511	phospholipase C
HEP75_01050	COG0189	ligase activity
HEP75_01052	COG0745	RESPONSE REGULATOR receiver
HEP75_01055	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HEP75_01059	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HEP75_01064	COG1216	Glycosyl transferase, family 2
HEP75_01070	COG2755	lipolytic protein G-D-S-L family
HEP75_01070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP75_01072	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP75_01072	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEP75_01074	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEP75_01076	COG1174	glycine betaine transport
HEP75_01077	COG1125	glycine betaine transport
HEP75_01079	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP75_01080	COG0564	pseudouridine synthase activity
HEP75_01084	COG0840	transmembrane signaling receptor activity
HEP75_01085	COG4993	Dehydrogenase
HEP75_01089	COG3387	PFAM Glycoside hydrolase 15-related
HEP75_01090	COG1877	trehalose-phosphatase activity
HEP75_01093	COG4771	TonB-dependent receptor
HEP75_01095	COG0454	-acetyltransferase
HEP75_01100	COG0542	response to heat
HEP75_01105	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_01108	COG2223	nitrite transmembrane transporter activity
HEP75_01110	COG0019	diaminopimelate decarboxylase activity
HEP75_01111	COG4264	IucA IucC family
HEP75_01112	COG2814	Major facilitator Superfamily
HEP75_01113	COG4264	IucA IucC family
HEP75_01115	COG4772	TonB-dependent receptor
HEP75_01117	COG4651	solute:proton antiporter activity
HEP75_01117	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP75_01123	COG0488	(ABC) transporter
HEP75_01129	COG0657	acetylesterase activity
HEP75_01129	COG2755	lipolytic protein G-D-S-L family
HEP75_01131	COG4774	siderophore transport
HEP75_01140	COG0217	transcriptional regulatory protein
HEP75_01142	COG0632	four-way junction helicase activity
HEP75_01145	COG0824	Thioesterase
HEP75_01147	COG0848	biopolymer transport protein
HEP75_01149	COG0823	Involved in the tonB-independent uptake of proteins
HEP75_01150	COG2885	chlorophyll binding
HEP75_01152	COG0602	queuosine metabolic process
HEP75_01153	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HEP75_01160	COG0514	ATP-dependent DNA helicase (RecQ)
HEP75_01162	COG0783	Belongs to the Dps family
HEP75_01163	COG1643	Atp-dependent helicase
HEP75_01170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP75_01172	COG1216	Glycosyl transferase, family 2
HEP75_01173	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP75_01175	COG1199	ATP-dependent helicase activity
HEP75_01177	COG1397	ADP-ribosylglycohydrolase
HEP75_01181	COG0189	ligase activity
HEP75_01184	COG0835	chemotaxis
HEP75_01185	COG0840	transmembrane signaling receptor activity
HEP75_01186	COG2198	Histidine kinase
HEP75_01186	COG0643	Histidine kinase
HEP75_01186	COG0784	Response regulator, receiver
HEP75_01187	COG2201	protein-glutamate methylesterase activity
HEP75_01190	COG1446	asparaginase
HEP75_01203	COG3279	Response regulator of the LytR AlgR family
HEP75_01204	COG3275	phosphorelay sensor kinase activity
HEP75_01205	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
HEP75_01209	COG0583	DNA-binding transcription factor activity
HEP75_01213	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP75_01221	COG3537	Alpha-1,2-mannosidase
HEP75_01223	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP75_01225	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HEP75_01226	COG3858	chitin binding
HEP75_01226	COG1388	LysM domain
HEP75_01230	COG0837	glucose binding
HEP75_01232	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HEP75_01234	COG0494	nUDIX hydrolase
HEP75_01236	COG3956	TIGRFAM MazG family protein
HEP75_01239	COG0330	HflC and HflK could
HEP75_01246	COG0697	spore germination
HEP75_01251	COG1960	acyl-CoA dehydrogenase activity
HEP75_01256	COG0457	Tetratricopeptide repeat
HEP75_01259	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HEP75_01260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP75_01261	COG0463	Glycosyl transferase, family 2
HEP75_01262	COG0517	IMP dehydrogenase activity
HEP75_01263	COG2982	Protein involved in outer membrane biogenesis
HEP75_01264	COG1272	protein, Hemolysin III
HEP75_01265	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HEP75_01267	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP75_01268	COG0626	cystathionine gamma-synthase activity
HEP75_01269	COG0527	aspartate kinase activity
HEP75_01269	COG0460	homoserine dehydrogenase
HEP75_01272	COG1760	l-serine dehydratase
HEP75_01275	COG3038	cytochrome b561
HEP75_01279	COG0477	Major facilitator Superfamily
HEP75_01280	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HEP75_01283	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEP75_01296	COG3706	GGDEF domain
HEP75_01304	COG0519	Catalyzes the synthesis of GMP from XMP
HEP75_01307	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEP75_01316	COG1113	amino acid transport
HEP75_01320	COG2239	Acts as a magnesium transporter
HEP75_01321	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP75_01322	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP75_01324	COG1660	Displays ATPase and GTPase activities
HEP75_01326	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP75_01329	COG1137	ATPase activity
HEP75_01332	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HEP75_01339	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEP75_01344	COG0628	permease
HEP75_01346	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP75_01347	COG3178	'Phosphotransferase
HEP75_01350	COG1555	photosystem II stabilization
HEP75_01356	COG2814	Major facilitator Superfamily
HEP75_01359	COG1335	isochorismatase
HEP75_01361	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP75_01362	COG1477	protein flavinylation
HEP75_01367	COG4774	siderophore transport
HEP75_01368	COG2146	nitrite reductase [NAD(P)H] activity
HEP75_01370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP75_01371	COG0719	Fe-S assembly protein
HEP75_01372	COG0396	ATPase activity
HEP75_01373	COG0719	Fe-S assembly protein
HEP75_01376	COG0693	protein deglycase activity
HEP75_01379	COG0739	heme binding
HEP75_01382	COG1764	response to oxidative stress
HEP75_01384	COG0384	phenazine biosynthesis protein PhzF
HEP75_01385	COG0527	aspartate kinase activity
HEP75_01390	COG0142	geranyltranstransferase activity
HEP75_01391	COG0629	single-stranded DNA binding
HEP75_01393	COG1858	cytochrome C peroxidase
HEP75_01399	COG4615	Cyclic peptide transporter
HEP75_01404	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_01405	COG0577	efflux transmembrane transporter activity
HEP75_01405	COG1136	(ABC) transporter
HEP75_01406	COG1136	(ABC) transporter
HEP75_01406	COG0577	efflux transmembrane transporter activity
HEP75_01409	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HEP75_01414	COG2010	Cytochrome c
HEP75_01416	COG0673	inositol 2-dehydrogenase activity
HEP75_01417	COG2211	Major facilitator Superfamily
HEP75_01419	COG1609	Transcriptional regulator
HEP75_01425	COG3104	oligopeptide transport
HEP75_01426	COG1297	OPT oligopeptide transporter protein
HEP75_01427	COG1506	peptidase
HEP75_01427	COG0823	Involved in the tonB-independent uptake of proteins
HEP75_01431	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP75_01432	COG2879	small protein
HEP75_01433	COG1966	Carbon starvation protein
HEP75_01434	COG1741	Belongs to the pirin family
HEP75_01436	COG1741	Belongs to the pirin family
HEP75_01438	COG1515	deoxyribonuclease V activity
HEP75_01442	COG2211	Major facilitator Superfamily
HEP75_01444	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP75_01447	COG5001	Diguanylate cyclase
HEP75_01447	COG4251	negative regulation of phosphorylation
HEP75_01447	COG3706	GGDEF domain
HEP75_01447	COG2203	Gaf domain
HEP75_01448	COG0835	chemotaxis
HEP75_01449	COG0840	transmembrane signaling receptor activity
HEP75_01451	COG0840	transmembrane signaling receptor activity
HEP75_01452	COG2198	Histidine kinase
HEP75_01452	COG0643	Histidine kinase
HEP75_01454	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HEP75_01457	COG3878	Protein conserved in bacteria
HEP75_01458	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HEP75_01460	COG0642	Histidine kinase
HEP75_01461	COG3111	PFAM Bacterial OB fold (BOF) protein
HEP75_01462	COG0745	RESPONSE REGULATOR receiver
HEP75_01463	COG2205	protein histidine kinase activity
HEP75_01464	COG4452	Inner membrane protein CreD
HEP75_01469	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP75_01470	COG0735	belongs to the Fur family
HEP75_01476	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP75_01478	COG1309	transcriptional regulator
HEP75_01481	COG3214	Protein conserved in bacteria
HEP75_01485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP75_01486	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEP75_01487	COG2080	2 iron, 2 sulfur cluster binding
HEP75_01494	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEP75_01507	COG1187	pseudouridine synthase activity
HEP75_01512	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP75_01513	COG3795	YCII-related domain
HEP75_01517	COG4941	Belongs to the sigma-70 factor family
HEP75_01522	COG1132	(ABC) transporter
HEP75_01529	COG0583	DNA-binding transcription factor activity
HEP75_01538	COG1981	membrane
HEP75_01540	COG0825	malonyl-CoA metabolic process
HEP75_01543	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP75_01544	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP75_01548	COG0750	zinc metalloprotease
HEP75_01549	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HEP75_01550	COG0575	Belongs to the CDS family
HEP75_01551	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEP75_01553	COG0528	UMP kinase activity
HEP75_01555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEP75_01563	COG0024	Methionine aminopeptidase
HEP75_01566	COG1393	Belongs to the ArsC family
HEP75_01567	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP75_01568	COG0367	asparagine synthase
HEP75_01579	COG1566	PFAM secretion protein HlyD family protein
HEP75_01580	COG2814	Major facilitator Superfamily
HEP75_01588	COG0557	exoribonuclease II activity
HEP75_01590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP75_01594	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP75_01598	COG0704	Plays a role in the regulation of phosphate uptake
HEP75_01600	COG0581	inorganic phosphate transmembrane transporter activity
HEP75_01603	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP75_01607	COG0659	secondary active sulfate transmembrane transporter activity
HEP75_01608	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HEP75_01610	COG1024	Enoyl-CoA hydratase
HEP75_01619	COG0488	(ABC) transporter
HEP75_01622	COG5002	protein histidine kinase activity
HEP75_01622	COG0784	Response regulator, receiver
HEP75_01622	COG2205	protein histidine kinase activity
HEP75_01623	COG2733	membrane
HEP75_01626	COG2205	protein histidine kinase activity
HEP75_01630	COG0686	Belongs to the AlaDH PNT family
HEP75_01631	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP75_01632	COG1917	Cupin 2, conserved barrel domain protein
HEP75_01632	COG1396	sequence-specific DNA binding
HEP75_01633	COG1012	belongs to the aldehyde dehydrogenase family
HEP75_01637	COG0243	molybdopterin cofactor binding
HEP75_01639	COG0477	Major facilitator Superfamily
HEP75_01641	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP75_01642	COG0174	glutamine synthetase
HEP75_01643	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HEP75_01644	COG0174	glutamine synthetase
HEP75_01646	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP75_01647	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP75_01651	COG3842	ATPase activity
HEP75_01652	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEP75_01653	COG1177	transmembrane transport
HEP75_01654	COG1012	belongs to the aldehyde dehydrogenase family
HEP75_01655	COG0598	Magnesium transport protein CorA
HEP75_01657	COG4535	Mg2 and Co2 transporter CorC
HEP75_01663	COG1702	phosphate starvation-inducible protein PhoH
HEP75_01666	COG0625	glutathione transferase activity
HEP75_01668	COG0741	lytic transglycosylase activity
HEP75_01669	COG0723	plastoquinol--plastocyanin reductase activity
HEP75_01670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP75_01672	COG2857	Cytochrome c1
HEP75_01673	COG0625	glutathione transferase activity
HEP75_01674	COG2969	positive regulation of protein catabolic process
HEP75_01682	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEP75_01683	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_01684	COG2095	MarC family integral membrane protein
HEP75_01687	COG1611	Belongs to the LOG family
HEP75_01688	COG3275	phosphorelay sensor kinase activity
HEP75_01698	COG0556	nucleotide-excision repair
HEP75_01705	COG2948	multi-organism process
HEP75_01713	COG0366	Alpha amylase catalytic
HEP75_01723	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEP75_01725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEP75_01726	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEP75_01727	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP75_01727	COG0072	phenylalanine-tRNA ligase activity
HEP75_01736	COG0438	transferase activity, transferring glycosyl groups
HEP75_01739	COG0438	transferase activity, transferring glycosyl groups
HEP75_01744	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEP75_01746	COG1960	acyl-CoA dehydrogenase activity
HEP75_01750	COG1846	Transcriptional regulator
HEP75_01758	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HEP75_01758	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEP75_01759	COG0802	atpase or kinase
HEP75_01760	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEP75_01761	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HEP75_01765	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_01769	COG2081	HI0933 family
HEP75_01770	COG4681	YaeQ
HEP75_01771	COG0564	pseudouridine synthase activity
HEP75_01773	COG0625	glutathione transferase activity
HEP75_01774	COG0657	acetylesterase activity
HEP75_01781	COG0513	Belongs to the DEAD box helicase family
HEP75_01782	COG0488	(ABC) transporter
HEP75_01785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HEP75_01786	COG2207	Transcriptional regulator
HEP75_01789	COG2197	response regulator
HEP75_01791	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP75_01798	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP75_01799	COG1846	Transcriptional regulator
HEP75_01800	COG0339	signal peptide processing
HEP75_01801	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP75_01802	COG0386	Belongs to the glutathione peroxidase family
HEP75_01808	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP75_01817	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HEP75_01820	COG0084	hydrolase, TatD family'
HEP75_01823	COG1960	acyl-CoA dehydrogenase activity
HEP75_01826	COG0305	Participates in initiation and elongation during chromosome replication
HEP75_01829	COG2204	response regulator
HEP75_01831	COG0415	Belongs to the DNA photolyase family
HEP75_01834	COG0583	DNA-binding transcription factor activity
HEP75_01837	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_01839	COG1201	RNA secondary structure unwinding
HEP75_01840	COG0840	transmembrane signaling receptor activity
HEP75_01840	COG3290	protein histidine kinase activity
HEP75_01841	COG0835	chemotaxis
HEP75_01848	COG2304	oxidoreductase activity
HEP75_01851	COG1194	a g-specific adenine glycosylase
HEP75_01852	COG0552	protein localization to endoplasmic reticulum
HEP75_01854	COG3938	Belongs to the proline racemase family
HEP75_01855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP75_01858	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP75_01860	COG0006	proline dipeptidase activity
HEP75_01863	COG0531	amino acid
HEP75_01870	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP75_01872	COG4771	TonB-dependent receptor
HEP75_01874	COG3345	alpha-galactosidase
HEP75_01878	COG3209	COG3209 Rhs family protein
HEP75_01880	COG0742	ribosomal rna small subunit methyltransferase
HEP75_01883	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEP75_01885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP75_01886	COG3291	Pkd domain containing protein
HEP75_01890	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEP75_01891	COG2755	lipolytic protein G-D-S-L family
HEP75_01891	COG0657	acetylesterase activity
HEP75_01893	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP75_01895	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEP75_01896	COG0343	queuine tRNA-ribosyltransferase activity
HEP75_01897	COG1862	Preprotein translocase
HEP75_01905	COG1509	lysine 2,3-aminomutase activity
HEP75_01907	COG3548	integral membrane protein
HEP75_01908	COG0402	S-adenosylhomocysteine deaminase activity
HEP75_01912	COG4677	pectinesterase activity
HEP75_01913	COG4302	ethanolamine ammonia-lyase activity
HEP75_01914	COG4303	Ethanolamine ammonia lyase large subunit
HEP75_01919	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP75_01925	COG4993	Dehydrogenase
HEP75_01925	COG2010	Cytochrome c
HEP75_01932	COG2166	iron-sulfur cluster assembly
HEP75_01935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEP75_01936	COG0137	argininosuccinate synthase activity
HEP75_01938	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP75_01939	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEP75_01941	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEP75_01942	COG0165	Argininosuccinate lyase
HEP75_01946	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEP75_01950	COG1064	alcohol dehydrogenase
HEP75_01956	COG1294	oxidase, subunit
HEP75_01958	COG4988	ABC transporter
HEP75_01959	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HEP75_01960	COG1278	Cold shock
HEP75_01961	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP75_01966	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HEP75_01970	COG4133	protoheme IX ABC transporter activity
HEP75_01971	COG0436	Aminotransferase
HEP75_01976	COG1187	pseudouridine synthase activity
HEP75_01977	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HEP75_01978	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HEP75_01979	COG2350	Protein conserved in bacteria
HEP75_01988	COG0395	ABC-type sugar transport system, permease component
HEP75_01990	COG0800	Aldolase
HEP75_01991	COG0129	dihydroxy-acid dehydratase activity
HEP75_01994	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEP75_01996	COG0354	folic acid binding
HEP75_01998	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HEP75_02003	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEP75_02006	COG2333	competence protein COMEC
HEP75_02006	COG0658	competence protein
HEP75_02007	COG0811	peptide transport
HEP75_02009	COG1132	(ABC) transporter
HEP75_02010	COG1663	tetraacyldisaccharide 4'-kinase activity
HEP75_02013	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP75_02016	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP75_02024	COG0348	domain, Protein
HEP75_02027	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEP75_02029	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HEP75_02030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEP75_02032	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP75_02040	COG0577	efflux transmembrane transporter activity
HEP75_02040	COG1136	(ABC) transporter
HEP75_02046	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP75_02046	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP75_02047	COG1105	Belongs to the carbohydrate kinase PfkB family
HEP75_02048	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP75_02048	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP75_02049	COG1609	Transcriptional regulator
HEP75_02052	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HEP75_02053	COG0069	glutamate synthase activity
HEP75_02060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP75_02063	COG1253	flavin adenine dinucleotide binding
HEP75_02065	COG0306	phosphate transporter
HEP75_02069	COG0504	CTP synthase activity
HEP75_02073	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HEP75_02074	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HEP75_02075	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HEP75_02078	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HEP75_02080	COG1238	metal cluster binding
HEP75_02083	COG1534	Rna-binding protein
HEP75_02084	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HEP75_02085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP75_02086	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEP75_02089	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEP75_02090	COG1546	Belongs to the CinA family
HEP75_02091	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP75_02092	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP75_02093	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HEP75_02094	COG2137	regulation of response to DNA damage stimulus
HEP75_02095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEP75_02096	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HEP75_02114	COG2003	Belongs to the UPF0758 family
HEP75_02136	COG0194	GDP metabolic process
HEP75_02139	COG1741	Belongs to the pirin family
HEP75_02140	COG0583	DNA-binding transcription factor activity
HEP75_02145	COG0351	phosphomethylpyrimidine kinase
HEP75_02145	COG0352	thiamine-phosphate diphosphorylase activity
HEP75_02148	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HEP75_02149	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEP75_02151	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP75_02153	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HEP75_02154	COG3734	2-keto-3-deoxy-galactonokinase
HEP75_02157	COG0800	Aldolase
HEP75_02164	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP75_02166	COG1070	Carbohydrate kinase
HEP75_02167	COG2115	Belongs to the xylose isomerase family
HEP75_02168	COG0477	Major facilitator Superfamily
HEP75_02170	COG0617	tRNA 3'-terminal CCA addition
HEP75_02172	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HEP75_02175	COG0166	Belongs to the GPI family
HEP75_02179	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HEP75_02182	COG0671	phosphoesterase, PA-phosphatase related
HEP75_02183	COG1794	racemase activity, acting on amino acids and derivatives
HEP75_02186	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEP75_02191	COG1012	belongs to the aldehyde dehydrogenase family
HEP75_02194	COG0527	aspartate kinase activity
HEP75_02194	COG0460	homoserine dehydrogenase
HEP75_02196	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEP75_02198	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP75_02199	COG0124	histidyl-tRNA synthetase
HEP75_02201	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HEP75_02202	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEP75_02203	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP75_02205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEP75_02208	COG0140	phosphoribosyl-ATP diphosphatase activity
HEP75_02208	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEP75_02211	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HEP75_02212	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HEP75_02213	COG0235	Class ii aldolase
HEP75_02214	COG0531	amino acid
HEP75_02215	COG0531	amino acid
HEP75_02218	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEP75_02219	COG0277	FAD linked oxidase domain protein
HEP75_02223	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEP75_02227	COG1024	Enoyl-CoA hydratase
HEP75_02234	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP75_02235	COG2258	MOSC domain
HEP75_02237	COG0505	Belongs to the CarA family
HEP75_02238	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEP75_02239	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP75_02242	COG4676	Protein conserved in bacteria
HEP75_02243	COG3279	Response regulator of the LytR AlgR family
HEP75_02244	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEP75_02247	COG0784	Response regulator, receiver
HEP75_02247	COG2205	protein histidine kinase activity
HEP75_02247	COG2198	Histidine kinase
HEP75_02248	COG1024	Enoyl-CoA hydratase
HEP75_02249	COG0318	PFAM AMP-dependent synthetase and ligase
HEP75_02263	COG0840	transmembrane signaling receptor activity
HEP75_02265	COG0835	chemotaxis
HEP75_02267	COG0840	transmembrane signaling receptor activity
HEP75_02268	COG0840	transmembrane signaling receptor activity
HEP75_02270	COG0840	transmembrane signaling receptor activity
HEP75_02271	COG0840	transmembrane signaling receptor activity
HEP75_02273	COG0840	transmembrane signaling receptor activity
HEP75_02275	COG0840	transmembrane signaling receptor activity
HEP75_02276	COG0840	transmembrane signaling receptor activity
HEP75_02277	COG0840	transmembrane signaling receptor activity
HEP75_02279	COG0745	RESPONSE REGULATOR receiver
HEP75_02282	COG1192	Involved in chromosome partitioning
HEP75_02283	COG1360	Flagellar Motor Protein
HEP75_02284	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HEP75_02285	COG2198	Histidine kinase
HEP75_02285	COG0784	Response regulator, receiver
HEP75_02285	COG0643	Histidine kinase
HEP75_02295	COG1684	flagellar biosynthetic protein fliR
HEP75_02296	COG1987	bacterial-type flagellum assembly
HEP75_02298	COG3190	flagellar
HEP75_02308	COG1677	Flagellar hook-basal body complex protein FliE
HEP75_02314	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_02315	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_02316	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP75_02320	COG2201	protein-glutamate methylesterase activity
HEP75_02322	COG2197	response regulator
HEP75_02326	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HEP75_02328	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HEP75_02329	COG1256	bacterial-type flagellum assembly
HEP75_02329	COG4786	Flagellar basal body rod
HEP75_02332	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HEP75_02335	COG1749	Flagellar hook protein flgE
HEP75_02336	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HEP75_02337	COG1558	bacterial-type flagellum-dependent cell motility
HEP75_02339	COG0784	Response regulator, receiver
HEP75_02339	COG0835	chemotaxis
HEP75_02348	COG1116	anion transmembrane transporter activity
HEP75_02351	COG2915	High frequency lysogenization protein hflD homolog
HEP75_02352	COG0482	sulfurtransferase activity
HEP75_02356	COG0542	response to heat
HEP75_02360	COG0492	ferredoxin-NADP+ reductase activity
HEP75_02361	COG1674	ftsk spoiiie
HEP75_02364	COG1230	cation diffusion facilitator family transporter
HEP75_02365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HEP75_02366	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP75_02370	COG0745	RESPONSE REGULATOR receiver
HEP75_02381	COG1595	DNA-templated transcription, initiation
HEP75_02385	COG3038	cytochrome b561
HEP75_02391	COG2244	polysaccharide biosynthetic process
HEP75_02399	COG0297	glycogen (starch) synthase activity
HEP75_02400	COG0438	transferase activity, transferring glycosyl groups
HEP75_02404	COG1132	(ABC) transporter
HEP75_02415	COG0577	efflux transmembrane transporter activity
HEP75_02415	COG1136	(ABC) transporter
HEP75_02419	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HEP75_02421	COG0714	Associated with various cellular activities
HEP75_02424	COG4585	Histidine kinase
HEP75_02426	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_02427	COG2197	response regulator
HEP75_02435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_02437	COG5000	phosphorelay sensor kinase activity
HEP75_02437	COG5002	protein histidine kinase activity
HEP75_02450	COG0784	Response regulator, receiver
HEP75_02450	COG2205	protein histidine kinase activity
HEP75_02451	COG2183	response to ionizing radiation
HEP75_02452	COG0784	Response regulator, receiver
HEP75_02452	COG4191	Histidine kinase
HEP75_02454	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HEP75_02454	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP75_02458	COG3243	poly(R)-hydroxyalkanoic acid synthase
HEP75_02460	COG1183	phosphatidylcholine synthase activity
HEP75_02461	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_02466	COG0668	transmembrane transport
HEP75_02467	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HEP75_02470	COG1914	H( )-stimulated, divalent metal cation uptake system
HEP75_02472	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HEP75_02474	COG0784	Response regulator, receiver
HEP75_02474	COG4191	Histidine kinase
HEP75_02475	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP75_02476	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP75_02477	COG1538	Outer membrane efflux protein
HEP75_02478	COG1309	transcriptional regulator
HEP75_02484	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_02487	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP75_02487	COG0519	Catalyzes the synthesis of GMP from XMP
HEP75_02489	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP75_02492	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP75_02492	COG0475	glutathione-regulated potassium exporter activity
HEP75_02493	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEP75_02495	COG0746	molybdenum cofactor guanylyltransferase activity
HEP75_02497	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP75_02501	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HEP75_02504	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP75_02504	COG1024	Enoyl-CoA hydratase
HEP75_02505	COG0183	Belongs to the thiolase family
HEP75_02506	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEP75_02509	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HEP75_02511	COG0776	regulation of translation
HEP75_02512	COG0539	negative regulation of cytoplasmic translation
HEP75_02513	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HEP75_02516	COG2957	Belongs to the agmatine deiminase family
HEP75_02517	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP75_02522	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_02526	COG0316	Belongs to the HesB IscA family
HEP75_02526	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HEP75_02529	COG0428	transporter
HEP75_02530	COG3064	Membrane
HEP75_02532	COG1530	ribonuclease E activity
HEP75_02535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP75_02538	COG0582	viral genome integration into host DNA
HEP75_02544	COG0583	DNA-binding transcription factor activity
HEP75_02549	COG0077	Prephenate dehydratase
HEP75_02549	COG1605	Chorismate mutase
HEP75_02550	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HEP75_02551	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP75_02552	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HEP75_02559	COG4221	oxidoreductase activity
HEP75_02565	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HEP75_02574	COG4993	Dehydrogenase
HEP75_02576	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HEP75_02578	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HEP75_02579	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP75_02580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP75_02586	COG2977	Belongs to the P-Pant transferase superfamily
HEP75_02587	COG0316	Belongs to the HesB IscA family
HEP75_02592	COG2197	response regulator
HEP75_02601	COG0288	reversible hydration of carbon dioxide
HEP75_02604	COG3844	kynureninase activity
HEP75_02606	COG2925	Exonuclease
HEP75_02613	COG2902	Dehydrogenase
HEP75_02615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_02616	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP75_02617	COG1960	acyl-CoA dehydrogenase activity
HEP75_02618	COG2226	methyltransferase
HEP75_02619	COG0646	methionine synthase
HEP75_02619	COG1410	methionine synthase
HEP75_02620	COG1410	methionine synthase
HEP75_02620	COG0646	methionine synthase
HEP75_02622	COG2755	lipolytic protein G-D-S-L family
HEP75_02622	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP75_02624	COG2900	Belongs to the SlyX family
HEP75_02627	COG0386	Belongs to the glutathione peroxidase family
HEP75_02629	COG1725	Transcriptional regulator
HEP75_02630	COG1131	(ABC) transporter
HEP75_02639	COG2885	chlorophyll binding
HEP75_02640	COG2850	peptidyl-arginine hydroxylation
HEP75_02651	COG1132	(ABC) transporter
HEP75_02653	COG0287	Prephenate dehydrogenase
HEP75_02653	COG1605	Chorismate mutase
HEP75_02654	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HEP75_02657	COG0484	heat shock protein binding
HEP75_02658	COG0443	Heat shock 70 kDa protein
HEP75_02659	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP75_02660	COG1420	regulation of RNA biosynthetic process
HEP75_02661	COG0497	DNA recombination
HEP75_02662	COG0735	belongs to the Fur family
HEP75_02663	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP75_02666	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HEP75_02667	COG1404	Belongs to the peptidase S8 family
HEP75_02671	COG0583	DNA-binding transcription factor activity
HEP75_02672	COG3706	GGDEF domain
HEP75_02677	COG3300	MHYT domain
HEP75_02677	COG5001	Diguanylate cyclase
HEP75_02678	COG1185	polyribonucleotide nucleotidyltransferase activity
HEP75_02683	COG0195	Participates in both transcription termination and antitermination
HEP75_02686	COG1007	ATP synthesis coupled electron transport
HEP75_02693	COG1034	ATP synthesis coupled electron transport
HEP75_02694	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEP75_02695	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HEP75_02696	COG0649	NAD binding
HEP75_02697	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP75_02699	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP75_02702	COG0149	triose-phosphate isomerase activity
HEP75_02703	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_02706	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HEP75_02716	COG0101	tRNA pseudouridine synthase activity
HEP75_02718	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEP75_02721	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP75_02723	COG0688	phosphatidylethanolamine metabolic process
HEP75_02724	COG0741	lytic transglycosylase activity
HEP75_02725	COG0433	COG0433 Predicted ATPase
HEP75_02726	COG0494	nUDIX hydrolase
HEP75_02729	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP75_02730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEP75_02735	COG0717	Belongs to the dCTP deaminase family
HEP75_02736	COG0489	protein tyrosine kinase activity
HEP75_02737	COG4771	TonB-dependent receptor
HEP75_02738	COG0457	Tetratricopeptide repeat
HEP75_02740	COG3590	peptidase
HEP75_02742	COG0705	Rhomboid family
HEP75_02744	COG0697	spore germination
HEP75_02746	COG2311	Membrane
HEP75_02747	COG1047	Peptidyl-prolyl cis-trans
HEP75_02748	COG0791	NLP P60 protein
HEP75_02749	COG0791	NLP P60 protein
HEP75_02750	COG1607	acyl-coa hydrolase
HEP75_02751	COG4106	trans-aconitate 2-methyltransferase activity
HEP75_02752	COG1301	dicarboxylic acid transport
HEP75_02753	COG1785	Belongs to the alkaline phosphatase family
HEP75_02755	COG0037	tRNA processing
HEP75_02756	COG1722	exodeoxyribonuclease VII activity
HEP75_02757	COG0142	geranyltranstransferase activity
HEP75_02759	COG4104	PAAR repeat-containing protein
HEP75_02766	COG0312	modulator of DNA gyrase
HEP75_02768	COG0312	modulator of DNA gyrase
HEP75_02772	COG2968	Membrane
HEP75_02775	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HEP75_02778	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEP75_02781	COG0495	leucyl-tRNA aminoacylation
HEP75_02783	COG3118	belongs to the thioredoxin family
HEP75_02787	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HEP75_02789	COG2040	homocysteine
HEP75_02791	COG0346	lactoylglutathione lyase activity
HEP75_02795	COG2878	Part of a membrane complex involved in electron transport
HEP75_02798	COG1595	DNA-templated transcription, initiation
HEP75_02803	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP75_02807	COG0251	oxidation-reduction process
HEP75_02809	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP75_02809	COG0392	lysyltransferase activity
HEP75_02816	COG2814	Major facilitator Superfamily
HEP75_02817	COG1902	pentaerythritol trinitrate reductase activity
HEP75_02819	COG0583	DNA-binding transcription factor activity
HEP75_02822	COG2824	Alkylphosphonate utilization operon protein PhnA
HEP75_02824	COG1047	Peptidyl-prolyl cis-trans
HEP75_02825	COG1077	Cell shape determining protein MreB Mrl
HEP75_02832	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HEP75_02834	COG1451	nucleotide metabolic process
HEP75_02838	COG2205	protein histidine kinase activity
HEP75_02840	COG2186	Transcriptional regulator
HEP75_02841	COG3250	beta-galactosidase activity
HEP75_02853	COG1703	isobutyryl-CoA mutase activity
HEP75_02853	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP75_02853	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP75_02859	COG0183	Belongs to the thiolase family
HEP75_02861	COG0443	Heat shock 70 kDa protein
HEP75_02867	COG1960	acyl-CoA dehydrogenase activity
HEP75_02868	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEP75_02868	COG1793	dna ligase
HEP75_02869	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEP75_02869	COG1793	dna ligase
HEP75_02870	COG1201	RNA secondary structure unwinding
HEP75_02872	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP75_02873	COG1278	Cold shock
HEP75_02874	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEP75_02875	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HEP75_02876	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP75_02878	COG2954	triphosphatase activity
HEP75_02880	COG0745	RESPONSE REGULATOR receiver
HEP75_02881	COG1381	Involved in DNA repair and RecF pathway recombination
HEP75_02882	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEP75_02885	COG0681	Belongs to the peptidase S26 family
HEP75_02886	COG0481	GTPase activity
HEP75_02887	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP75_02890	COG1024	Enoyl-CoA hydratase
HEP75_02890	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP75_02894	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_02895	COG2855	membrane
HEP75_02898	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HEP75_02899	COG3250	beta-galactosidase activity
HEP75_02900	COG3540	Alkaline phosphatase
HEP75_02905	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HEP75_02908	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HEP75_02911	COG0534	Mate efflux family protein
HEP75_02912	COG0335	large ribosomal subunit rRNA binding
HEP75_02913	COG0336	Belongs to the RNA methyltransferase TrmD family
HEP75_02914	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HEP75_02915	COG0228	four-way junction DNA binding
HEP75_02917	COG2070	2-Nitropropane dioxygenase
HEP75_02918	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HEP75_02923	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP75_02927	COG0475	glutathione-regulated potassium exporter activity
HEP75_02931	COG0625	glutathione transferase activity
HEP75_02932	COG1082	Xylose isomerase domain protein TIM barrel
HEP75_02934	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP75_02935	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP75_02936	COG1129	ABC transporter
HEP75_02937	COG1879	ABC-type sugar transport system periplasmic component
HEP75_02938	COG1012	belongs to the aldehyde dehydrogenase family
HEP75_02941	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_02942	COG0129	dihydroxy-acid dehydratase activity
HEP75_02949	COG3152	Membrane
HEP75_02953	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HEP75_02954	COG1845	cytochrome c oxidase, subunit III
HEP75_02955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP75_02957	COG2964	Protein conserved in bacteria
HEP75_02960	COG4771	TonB-dependent receptor
HEP75_02965	COG0251	oxidation-reduction process
HEP75_02970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HEP75_02973	COG0196	riboflavin kinase activity
HEP75_02974	COG0728	peptidoglycan biosynthetic process
HEP75_02976	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEP75_02977	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HEP75_02978	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HEP75_02979	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP75_02980	COG0824	Thioesterase
HEP75_02982	COG1024	Enoyl-CoA hydratase
HEP75_02982	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP75_02983	COG1946	Acyl-CoA thioesterase
HEP75_02986	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HEP75_02989	COG0840	transmembrane signaling receptor activity
HEP75_02993	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HEP75_02994	COG4638	Rieske (2fe-2S)
HEP75_02999	COG1073	alpha beta
HEP75_03005	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HEP75_03009	COG4585	Histidine kinase
HEP75_03012	COG0850	regulation of cytokinetic process
HEP75_03013	COG2894	cell division
HEP75_03014	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HEP75_03016	COG2205	protein histidine kinase activity
HEP75_03017	COG0745	RESPONSE REGULATOR receiver
HEP75_03019	COG2194	sulfuric ester hydrolase activity
HEP75_03022	COG3209	COG3209 Rhs family protein
HEP75_03026	COG2814	Major facilitator Superfamily
HEP75_03029	COG4251	negative regulation of phosphorylation
HEP75_03029	COG5001	Diguanylate cyclase
HEP75_03029	COG3706	GGDEF domain
HEP75_03029	COG2203	Gaf domain
HEP75_03030	COG0753	catalase activity
HEP75_03035	COG1063	alcohol dehydrogenase
HEP75_03037	COG3459	Glycosyltransferase 36 associated
HEP75_03038	COG2186	Transcriptional regulator
HEP75_03042	COG2271	Major facilitator Superfamily
HEP75_03043	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_03050	COG1064	alcohol dehydrogenase
HEP75_03054	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_03055	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_03058	COG0492	ferredoxin-NADP+ reductase activity
HEP75_03064	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_03065	COG3387	PFAM Glycoside hydrolase 15-related
HEP75_03067	COG3275	phosphorelay sensor kinase activity
HEP75_03078	COG1196	nuclear chromosome segregation
HEP75_03089	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEP75_03091	COG0330	HflC and HflK could
HEP75_03092	COG0330	HflC and HflK could
HEP75_03093	COG0604	alcohol dehydrogenase
HEP75_03097	COG0678	peroxiredoxin activity
HEP75_03099	COG4953	penicillin-binding protein 1C
HEP75_03100	COG1349	DNA-binding transcription factor activity
HEP75_03102	COG2223	nitrite transmembrane transporter activity
HEP75_03108	COG0577	efflux transmembrane transporter activity
HEP75_03108	COG1136	(ABC) transporter
HEP75_03112	COG2373	Large extracellular alpha-helical protein
HEP75_03122	COG0372	Belongs to the citrate synthase family
HEP75_03124	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP75_03133	COG2161	toxin-antitoxin pair type II binding
HEP75_03134	COG4115	mRNA cleavage
HEP75_03138	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEP75_03139	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEP75_03140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEP75_03142	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP75_03143	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_03144	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HEP75_03145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP75_03147	COG1399	metal-binding, possibly nucleic acid-binding protein
HEP75_03152	COG0714	Associated with various cellular activities
HEP75_03156	COG0537	adenosine 5'-monophosphoramidase activity
HEP75_03161	COG0314	molybdopterin synthase activity
HEP75_03162	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HEP75_03163	COG0315	cyclic pyranopterin monophosphate synthase activity
HEP75_03165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEP75_03166	COG1234	tRNA 3'-trailer cleavage
HEP75_03168	COG0859	PFAM glycosyl transferase family 9
HEP75_03171	COG0631	protein serine/threonine phosphatase activity
HEP75_03172	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP75_03175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP75_03176	COG3942	CHAP domain
HEP75_03176	COG1388	LysM domain
HEP75_03183	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEP75_03185	COG0544	peptidyl-prolyl cis-trans isomerase activity
HEP75_03194	COG0473	3-isopropylmalate dehydrogenase activity
HEP75_03197	COG4783	chaperone-mediated protein folding
HEP75_03200	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HEP75_03201	COG0248	Ppx GppA phosphatase
HEP75_03202	COG0438	transferase activity, transferring glycosyl groups
HEP75_03204	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP75_03206	COG3291	Pkd domain containing protein
HEP75_03207	COG2833	Protein of unknown function (DUF455)
HEP75_03211	COG0285	dihydrofolate synthase activity
HEP75_03212	COG0588	phosphoglycerate mutase activity
HEP75_03216	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HEP75_03217	COG4208	sulfate ABC transporter
HEP75_03218	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HEP75_03219	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HEP75_03224	COG2885	chlorophyll binding
HEP75_03225	COG0583	DNA-binding transcription factor activity
HEP75_03226	COG2814	Major facilitator Superfamily
HEP75_03228	COG0667	Aldo Keto reductase
HEP75_03230	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP75_03230	COG1902	pentaerythritol trinitrate reductase activity
HEP75_03238	COG0625	glutathione transferase activity
HEP75_03240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP75_03244	COG0039	L-malate dehydrogenase activity
HEP75_03246	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEP75_03247	COG1217	gtp-binding protein TYPA
HEP75_03249	COG0154	amidase activity
HEP75_03251	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HEP75_03253	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HEP75_03254	COG0203	ribosomal protein L17
HEP75_03256	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEP75_03259	COG0201	protein transport
HEP75_03261	COG1841	ribosomal large subunit assembly
HEP75_03267	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEP75_03268	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEP75_03270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEP75_03271	COG0255	Belongs to the universal ribosomal protein uL29 family
HEP75_03276	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEP75_03277	COG0089	rRNA binding
HEP75_03278	COG0088	Forms part of the polypeptide exit tunnel
HEP75_03280	COG0051	transcription antitermination factor activity, RNA binding
HEP75_03281	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP75_03282	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP75_03285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEP75_03287	COG0222	ribosome binding
HEP75_03290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEP75_03291	COG0250	Participates in transcription elongation, termination and antitermination
HEP75_03294	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP75_03298	COG0012	GTP binding
HEP75_03299	COG0193	aminoacyl-tRNA hydrolase activity
HEP75_03301	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEP75_03303	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HEP75_03306	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HEP75_03307	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEP75_03310	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEP75_03313	COG1254	Belongs to the acylphosphatase family
HEP75_03314	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP75_03315	COG1295	ribonuclease BN
HEP75_03319	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEP75_03320	COG1404	Belongs to the peptidase S8 family
HEP75_03321	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEP75_03322	COG2151	metal-sulfur cluster biosynthetic enzyme
HEP75_03333	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP75_03333	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP75_03334	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_03335	COG0583	DNA-binding transcription factor activity
HEP75_03341	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP75_03343	COG3634	alkyl hydroperoxide reductase activity
HEP75_03344	COG0583	DNA-binding transcription factor activity
HEP75_03346	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP75_03347	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP75_03351	COG2197	response regulator
HEP75_03356	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP75_03358	COG0697	spore germination
HEP75_03368	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP75_03369	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP75_03371	COG2096	Adenosyltransferase
HEP75_03374	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HEP75_03375	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HEP75_03377	COG2967	ApaG domain
HEP75_03378	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HEP75_03385	COG1704	LemA family
HEP75_03386	COG0861	Integral membrane protein TerC family
HEP75_03387	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HEP75_03390	COG2205	protein histidine kinase activity
HEP75_03394	COG0642	Histidine kinase
HEP75_03397	COG4181	ATPase activity
HEP75_03398	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HEP75_03402	COG4771	TonB-dependent receptor
HEP75_03404	COG0667	Aldo Keto reductase
HEP75_03405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HEP75_03409	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEP75_03413	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP75_03414	COG4305	rare lipoprotein A
HEP75_03417	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_03418	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEP75_03420	COG4191	Histidine kinase
HEP75_03421	COG0784	Response regulator, receiver
HEP75_03422	COG2202	Pas domain
HEP75_03422	COG2205	protein histidine kinase activity
HEP75_03424	COG2823	Periplasmic or secreted lipoprotein
HEP75_03425	COG0673	inositol 2-dehydrogenase activity
HEP75_03426	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP75_03428	COG1090	epimerase
HEP75_03434	COG1056	cytidyltransferase-related domain
HEP75_03434	COG1051	belongs to the nudix hydrolase family
HEP75_03440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEP75_03441	COG0321	lipoyl(octanoyl) transferase activity
HEP75_03444	COG1686	Belongs to the peptidase S11 family
HEP75_03446	COG2951	lytic endotransglycosylase activity
HEP75_03447	COG1012	belongs to the aldehyde dehydrogenase family
HEP75_03449	COG0772	Belongs to the SEDS family
HEP75_03450	COG0768	penicillin binding
HEP75_03452	COG1792	Involved in formation and maintenance of cell shape
HEP75_03453	COG1077	Cell shape determining protein MreB Mrl
HEP75_03454	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP75_03455	COG3284	Transcriptional regulator
HEP75_03457	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEP75_03459	COG2010	Cytochrome c
HEP75_03464	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP75_03464	COG0596	Alpha beta hydrolase
HEP75_03465	COG0308	aminopeptidase N
HEP75_03466	COG2226	methyltransferase
HEP75_03473	COG0494	nUDIX hydrolase
HEP75_03476	COG0739	heme binding
HEP75_03478	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HEP75_03479	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEP75_03481	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HEP75_03482	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP75_03484	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP75_03487	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HEP75_03490	COG3116	cell division
HEP75_03491	COG0275	rRNA processing
HEP75_03492	COG2001	Belongs to the MraZ family
HEP75_03497	COG1988	membrane-bound metal-dependent
HEP75_03498	COG0277	FAD linked oxidase domain protein
HEP75_03499	COG0745	RESPONSE REGULATOR receiver
HEP75_03500	COG2205	protein histidine kinase activity
HEP75_03502	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP75_03503	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEP75_03507	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HEP75_03508	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP75_03509	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HEP75_03512	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP75_03512	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP75_03514	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HEP75_03519	COG0477	Major facilitator Superfamily
HEP75_03520	COG0488	(ABC) transporter
HEP75_03521	COG0242	peptide deformylase activity
HEP75_03523	COG1960	acyl-CoA dehydrogenase activity
HEP75_03525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP75_03527	COG1696	Membrane protein involved in D-alanine export
HEP75_03531	COG1215	transferase activity, transferring glycosyl groups
HEP75_03533	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HEP75_03534	COG0457	Tetratricopeptide repeat
HEP75_03535	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HEP75_03536	COG1215	transferase activity, transferring glycosyl groups
HEP75_03537	COG1215	transferase activity, transferring glycosyl groups
HEP75_03549	COG2188	Transcriptional regulator
HEP75_03552	COG1450	Type ii and iii secretion system protein
HEP75_03555	COG3166	PFAM Fimbrial assembly family protein
HEP75_03556	COG3156	type II secretion system protein K
HEP75_03557	COG4795	General secretion pathway protein
HEP75_03558	COG2165	general secretion pathway protein
HEP75_03559	COG4970	Tfp pilus assembly protein FimT
HEP75_03560	COG2165	general secretion pathway protein
HEP75_03561	COG1459	type II secretion system
HEP75_03562	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEP75_03563	COG1404	Belongs to the peptidase S8 family
HEP75_03564	COG5295	Hep Hag repeat protein
HEP75_03565	COG0047	phosphoribosylformylglycinamidine synthase activity
HEP75_03565	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEP75_03566	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP75_03567	COG4974	Belongs to the 'phage' integrase family
HEP75_03572	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP75_03579	COG1183	phosphatidylcholine synthase activity
HEP75_03581	COG0442	prolyl-tRNA aminoacylation
HEP75_03584	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEP75_03585	COG1127	ABC transporter
HEP75_03586	COG3218	ABC-type transport auxiliary lipoprotein component
HEP75_03586	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEP75_03593	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP75_03594	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HEP75_03594	COG0662	Cupin 2, conserved barrel domain protein
HEP75_03599	COG2086	electron transfer activity
HEP75_03602	COG0546	phosphoglycolate phosphatase activity
HEP75_03602	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEP75_03603	COG0277	FAD linked oxidase domain protein
HEP75_03604	COG0300	oxidoreductase activity
HEP75_03605	COG2226	methyltransferase
HEP75_03606	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP75_03612	COG2226	methyltransferase
HEP75_03614	COG3754	Rhamnan synthesis protein F
HEP75_03615	COG0438	transferase activity, transferring glycosyl groups
HEP75_03615	COG1216	Glycosyl transferase, family 2
HEP75_03619	COG0626	cystathionine gamma-synthase activity
HEP75_03625	COG0625	glutathione transferase activity
HEP75_03627	COG0513	Belongs to the DEAD box helicase family
HEP75_03628	COG0720	synthase
HEP75_03630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEP75_03631	COG1956	GAF domain-containing protein
HEP75_03633	COG4206	TonB-dependent receptor
HEP75_03634	COG0546	phosphoglycolate phosphatase activity
HEP75_03638	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEP75_03642	COG0339	signal peptide processing
HEP75_03643	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEP75_03645	COG2217	Heavy metal translocating P-type atpase
HEP75_03648	COG2132	Multicopper oxidase
HEP75_03653	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP75_03655	COG1136	(ABC) transporter
HEP75_03656	COG0577	efflux transmembrane transporter activity
HEP75_03657	COG0577	efflux transmembrane transporter activity
HEP75_03658	COG0577	efflux transmembrane transporter activity
HEP75_03659	COG0577	efflux transmembrane transporter activity
HEP75_03660	COG0577	efflux transmembrane transporter activity
HEP75_03660	COG1136	(ABC) transporter
HEP75_03661	COG0577	efflux transmembrane transporter activity
HEP75_03661	COG1136	(ABC) transporter
HEP75_03663	COG0577	efflux transmembrane transporter activity
HEP75_03663	COG1136	(ABC) transporter
HEP75_03666	COG4191	Histidine kinase
HEP75_03668	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEP75_03671	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HEP75_03674	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEP75_03676	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEP75_03678	COG0356	it plays a direct role in the translocation of protons across the membrane
HEP75_03682	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP75_03683	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP75_03690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEP75_03691	COG0697	spore germination
HEP75_03692	COG1666	GTP binding
HEP75_03694	COG1187	pseudouridine synthase activity
HEP75_03699	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP75_03699	COG2205	protein histidine kinase activity
HEP75_03704	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP75_03716	COG0842	Transport permease protein
HEP75_03717	COG1131	(ABC) transporter
HEP75_03719	COG0025	NhaP-type Na H and K H
HEP75_03721	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HEP75_03722	COG1573	uracil-dna glycosylase
HEP75_03724	COG3384	dioxygenase
HEP75_03728	COG0667	Aldo Keto reductase
HEP75_03729	COG0667	Aldo Keto reductase
HEP75_03732	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP75_03733	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP75_03738	COG5001	Diguanylate cyclase
HEP75_03744	COG3275	phosphorelay sensor kinase activity
HEP75_03749	COG0531	amino acid
HEP75_03753	COG5297	Belongs to the glycosyl hydrolase family 6
HEP75_03753	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP75_03754	COG0612	Peptidase, M16
HEP75_03759	COG0741	lytic transglycosylase activity
HEP75_03765	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HEP75_03766	COG2207	Transcriptional regulator
HEP75_03769	COG0598	Magnesium transport protein CorA
HEP75_03770	COG1113	amino acid transport
HEP75_03772	COG0697	spore germination
HEP75_03779	COG2409	Drug exporters of the RND superfamily
HEP75_03780	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP75_03782	COG5520	Belongs to the glycosyl hydrolase 30 family
HEP75_03810	COG0584	glycerophosphoryl diester phosphodiesterase
HEP75_03813	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HEP75_03816	COG2827	Endonuclease containing a URI domain
HEP75_03817	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEP75_03822	COG1595	DNA-templated transcription, initiation
HEP75_03823	COG0459	protein refolding
HEP75_03825	COG2356	endonuclease I
HEP75_03826	COG1324	tolerance protein
HEP75_03828	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP75_03831	COG1733	regulation of RNA biosynthetic process
HEP75_03832	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HEP75_03833	COG0511	ligase activity, forming carbon-carbon bonds
HEP75_03835	COG0439	Biotin carboxylase
HEP75_03837	COG0300	oxidoreductase activity
HEP75_03840	COG2264	protein methyltransferase activity
HEP75_03844	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HEP75_03845	COG4589	Belongs to the CDS family
HEP75_03850	COG2453	phosphatase
HEP75_03850	COG0671	phosphoesterase, PA-phosphatase related
HEP75_03851	COG2267	carboxylic ester hydrolase activity
HEP75_03852	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP75_03853	COG0138	bifunctional purine biosynthesis protein purh
HEP75_03855	COG0151	Belongs to the GarS family
HEP75_03857	COG1289	transmembrane transporter activity
HEP75_03858	COG2814	Major facilitator Superfamily
HEP75_03875	COG2906	2 iron, 2 sulfur cluster binding
HEP75_03881	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HEP75_03884	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HEP75_03885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP75_03886	COG0730	response to heat
HEP75_03888	COG0134	indole-3-glycerol-phosphate synthase activity
HEP75_03890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEP75_03896	COG1597	lipid kinase activity
HEP75_03899	COG0484	heat shock protein binding
HEP75_03901	COG2814	Major facilitator Superfamily
HEP75_03902	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
HEP75_03906	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP75_03907	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEP75_03907	COG2111	Na H antiporter
HEP75_03908	COG1006	Multisubunit Na H antiporter MnhC subunit
HEP75_03909	COG0651	ATP synthesis coupled electron transport
HEP75_03911	COG2212	antiporter activity
HEP75_03912	COG1320	monovalent cation:proton antiporter activity
HEP75_03917	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HEP75_03921	COG3104	oligopeptide transport
HEP75_03922	COG3483	tryptophan 2,3-dioxygenase activity
HEP75_03925	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HEP75_03930	COG3227	Zinc metalloprotease (Elastase)
HEP75_03931	COG0513	Belongs to the DEAD box helicase family
HEP75_03933	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_03935	COG0702	epimerase
HEP75_03936	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP75_03938	COG2354	Protein conserved in bacteria
HEP75_03941	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP75_03943	COG1196	nuclear chromosome segregation
HEP75_03943	COG3264	Mechanosensitive ion channel
HEP75_03944	COG0604	alcohol dehydrogenase
HEP75_03944	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_03944	COG3321	synthase
HEP75_03948	COG1595	DNA-templated transcription, initiation
HEP75_03951	COG0477	Major facilitator Superfamily
HEP75_03952	COG1802	Transcriptional regulator
HEP75_03955	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HEP75_03962	COG1414	Transcriptional regulator
HEP75_03963	COG0738	Major facilitator superfamily
HEP75_03964	COG3254	rhamnose metabolic process
HEP75_03965	COG4948	Mandelate Racemase Muconate Lactonizing
HEP75_03966	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP75_03967	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_03975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP75_03978	COG4807	Protein conserved in bacteria
HEP75_03983	COG0708	Exodeoxyribonuclease III
HEP75_03988	COG5507	3-demethylubiquinone-9 3-methyltransferase
HEP75_03989	COG4773	Receptor
HEP75_03995	COG3220	belongs to the UPF0276 family
HEP75_04012	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP75_04018	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP75_04019	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP75_04022	COG0753	catalase activity
HEP75_04025	COG4773	Receptor
HEP75_04027	COG2197	response regulator
HEP75_04028	COG4585	Histidine kinase
HEP75_04030	COG1131	(ABC) transporter
HEP75_04031	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP75_04032	COG1136	(ABC) transporter
HEP75_04033	COG0577	efflux transmembrane transporter activity
HEP75_04036	COG2962	Rard protein
HEP75_04037	COG0697	spore germination
HEP75_04038	COG2133	pyrroloquinoline quinone binding
HEP75_04040	COG1028	Short-chain dehydrogenase reductase Sdr
HEP75_04041	COG0583	DNA-binding transcription factor activity
HEP75_04044	COG0180	Tryptophanyl-tRNA synthetase
HEP75_04046	COG3237	CsbD-like
HEP75_04053	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HEP75_04053	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HEP75_04061	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEP75_04069	COG1222	aaa ATPase
HEP75_04089	COG2084	Dehydrogenase
HEP75_04090	COG1902	pentaerythritol trinitrate reductase activity
HEP75_04097	COG1404	Belongs to the peptidase S8 family
HEP75_04098	COG2814	Major facilitator Superfamily
HEP75_04099	COG0583	DNA-binding transcription factor activity
HEP75_04103	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP75_04104	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP75_04110	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HEP75_04112	COG1764	response to oxidative stress
HEP75_04113	COG1846	Transcriptional regulator
HEP75_04114	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HEP75_04116	COG0697	spore germination
HEP75_04117	COG0523	cobalamin synthesis protein
HEP75_04120	COG3245	cytochrome
HEP75_04122	COG1960	acyl-CoA dehydrogenase activity
HEP75_04123	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP75_04135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEP75_04136	COG3387	PFAM Glycoside hydrolase 15-related
HEP75_04137	COG0745	RESPONSE REGULATOR receiver
HEP75_04140	COG1404	Belongs to the peptidase S8 family
HEP75_04142	COG3100	YcgL domain-containing protein
HEP75_04143	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP75_04145	COG0463	Glycosyl transferase, family 2
HEP75_04154	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HEP75_04157	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP75_04162	COG1294	oxidase, subunit
HEP75_04163	COG1271	oxidase subunit
HEP75_04167	COG0408	coproporphyrinogen oxidase activity
HEP75_04169	COG2323	membrane
HEP75_04178	COG0515	serine threonine protein kinase
HEP75_04179	COG0631	protein serine/threonine phosphatase activity
HEP75_04202	COG0589	response to stress
HEP75_04207	COG3275	phosphorelay sensor kinase activity
HEP75_04208	COG3279	Response regulator of the LytR AlgR family
HEP75_04210	COG0210	DNA helicase
HEP75_04226	COG0463	Glycosyl transferase, family 2
HEP75_04228	COG1475	DNA binding
HEP75_04229	COG1192	Involved in chromosome partitioning
HEP75_04230	COG0357	Ribosomal RNA small subunit methyltransferase G
HEP75_04232	COG2091	lysine biosynthetic process via aminoadipic acid
HEP75_04237	COG1011	Hydrolase
HEP75_04238	COG0477	Major facilitator Superfamily
HEP75_04242	COG1971	Probably functions as a manganese efflux pump
HEP75_04245	COG0457	Tetratricopeptide repeat
HEP75_04246	COG2205	protein histidine kinase activity
HEP75_04248	COG5001	Diguanylate cyclase
HEP75_04249	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP75_04250	COG3459	Glycosyltransferase 36 associated
HEP75_04251	COG2211	Major facilitator Superfamily
HEP75_04252	COG3265	gluconokinase activity
HEP75_04253	COG2155	Conserved Protein
HEP75_04254	COG2094	Belongs to the DNA glycosylase MPG family
HEP75_04257	COG2911	Protein conserved in bacteria
HEP75_04258	COG0729	surface antigen
HEP75_04261	COG3132	Protein of unknown function, DUF480
HEP75_04269	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HEP75_04270	COG0284	orotidine-5'-phosphate decarboxylase activity
HEP75_04276	COG2937	Belongs to the GPAT DAPAT family
HEP75_04280	COG2211	Major facilitator Superfamily
HEP75_04283	COG3693	PFAM glycoside hydrolase, family 10
HEP75_04285	COG3250	beta-galactosidase activity
HEP75_04289	COG3386	PFAM SMP-30 Gluconolaconase
HEP75_04292	COG0667	Aldo Keto reductase
HEP75_04293	COG0583	DNA-binding transcription factor activity
HEP75_04307	COG0246	Mannitol dehydrogenase
HEP75_04308	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP75_04310	COG4948	Mandelate Racemase Muconate Lactonizing
HEP75_04312	COG3661	Belongs to the glycosyl hydrolase 67 family
HEP75_04314	COG2115	Belongs to the xylose isomerase family
HEP75_04316	COG0037	tRNA processing
HEP75_04319	COG0840	transmembrane signaling receptor activity
HEP75_04321	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HEP75_04323	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP75_04325	COG0805	protein transport
HEP75_04327	COG0519	Catalyzes the synthesis of GMP from XMP
HEP75_04327	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP75_04329	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEP75_04332	COG0210	DNA helicase
HEP75_04333	COG1435	thymidine kinase activity
HEP75_04335	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HEP75_04338	COG2815	serine threonine protein kinase
HEP75_04338	COG0515	serine threonine protein kinase
HEP75_04340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP75_04344	COG1119	ATPase activity
HEP75_04348	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HEP75_04350	COG1335	isochorismatase
HEP75_04354	COG1733	regulation of RNA biosynthetic process
HEP75_04358	COG0706	membrane insertase activity
HEP75_04359	COG0594	ribonuclease P activity