locus-tag	class	description
HEP74_00002	COG0592	DNA-directed DNA polymerase activity
HEP74_00003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP74_00004	COG0187	DNA topoisomerase II activity
HEP74_00005	COG1266	CAAX protease self-immunity
HEP74_00006	COG0501	Belongs to the peptidase M48B family
HEP74_00013	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HEP74_00015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP74_00020	COG1280	lysine exporter protein (LysE YggA)
HEP74_00025	COG4772	TonB-dependent receptor
HEP74_00029	COG3284	Transcriptional regulator
HEP74_00030	COG1012	belongs to the aldehyde dehydrogenase family
HEP74_00038	COG0277	FAD linked oxidase domain protein
HEP74_00039	COG1304	FMN binding
HEP74_00040	COG2186	Transcriptional regulator
HEP74_00043	COG4585	Histidine kinase
HEP74_00067	COG4771	TonB-dependent receptor
HEP74_00077	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HEP74_00080	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP74_00083	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_00085	COG2755	lipolytic protein G-D-S-L family
HEP74_00087	COG3186	Phenylalanine-4-hydroxylase
HEP74_00088	COG1522	sequence-specific DNA binding
HEP74_00091	COG1752	Esterase of the alpha-beta hydrolase superfamily
HEP74_00093	COG1595	DNA-templated transcription, initiation
HEP74_00095	COG3220	belongs to the UPF0276 family
HEP74_00105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HEP74_00112	COG1929	Belongs to the glycerate kinase type-1 family
HEP74_00114	COG2814	Major facilitator Superfamily
HEP74_00116	COG0531	amino acid
HEP74_00117	COG4566	intracellular signal transduction
HEP74_00118	COG4191	Histidine kinase
HEP74_00123	COG0625	glutathione transferase activity
HEP74_00124	COG1322	Protein conserved in bacteria
HEP74_00126	COG0386	Belongs to the glutathione peroxidase family
HEP74_00127	COG2853	Lipoprotein
HEP74_00130	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEP74_00131	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEP74_00132	COG1127	ABC transporter
HEP74_00140	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HEP74_00141	COG1074	ATP-dependent DNA helicase activity
HEP74_00143	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEP74_00147	COG0537	adenosine 5'-monophosphoramidase activity
HEP74_00158	COG0477	Major facilitator Superfamily
HEP74_00159	COG0302	gtp cyclohydrolase
HEP74_00164	COG0730	response to heat
HEP74_00167	COG2951	lytic endotransglycosylase activity
HEP74_00172	COG3135	benzoate transporter
HEP74_00179	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP74_00180	COG1803	Methylglyoxal synthase
HEP74_00181	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP74_00182	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP74_00184	COG0493	'glutamate synthase
HEP74_00185	COG0067	glutamate synthase
HEP74_00185	COG0069	glutamate synthase activity
HEP74_00185	COG0070	glutamate synthase
HEP74_00190	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_00197	COG1205	dead DEAH box helicase
HEP74_00197	COG1111	helicase
HEP74_00198	COG3549	Plasmid maintenance system killer
HEP74_00210	COG2271	Major facilitator Superfamily
HEP74_00212	COG0657	acetylesterase activity
HEP74_00224	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP74_00225	COG1192	Involved in chromosome partitioning
HEP74_00228	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP74_00229	COG2050	protein possibly involved in aromatic compounds catabolism
HEP74_00233	COG1881	PFAM PEBP family protein
HEP74_00235	COG0174	glutamine synthetase
HEP74_00236	COG0347	Belongs to the P(II) protein family
HEP74_00237	COG0004	ammonium transporteR
HEP74_00238	COG3852	Histidine kinase
HEP74_00239	COG2204	response regulator
HEP74_00240	COG2032	superoxide dismutase activity
HEP74_00241	COG2032	superoxide dismutase activity
HEP74_00243	COG0183	Belongs to the thiolase family
HEP74_00252	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP74_00258	COG0702	epimerase
HEP74_00259	COG0583	DNA-binding transcription factor activity
HEP74_00262	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HEP74_00264	COG0612	Peptidase, M16
HEP74_00266	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP74_00268	COG0596	Alpha beta hydrolase
HEP74_00270	COG0727	PFAM Uncharacterised protein family (UPF0153)
HEP74_00271	COG0318	PFAM AMP-dependent synthetase and ligase
HEP74_00274	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP74_00280	COG0564	pseudouridine synthase activity
HEP74_00286	COG1595	DNA-templated transcription, initiation
HEP74_00287	COG1446	asparaginase
HEP74_00288	COG0339	signal peptide processing
HEP74_00289	COG0681	Belongs to the peptidase S26 family
HEP74_00294	COG0583	DNA-binding transcription factor activity
HEP74_00295	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HEP74_00296	COG2224	Isocitrate lyase
HEP74_00303	COG0659	secondary active sulfate transmembrane transporter activity
HEP74_00310	COG0583	DNA-binding transcription factor activity
HEP74_00311	COG1959	2 iron, 2 sulfur cluster binding
HEP74_00313	COG1690	Belongs to the RtcB family
HEP74_00316	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP74_00317	COG2130	NADP-dependent
HEP74_00320	COG1187	pseudouridine synthase activity
HEP74_00322	COG1643	Atp-dependent helicase
HEP74_00323	COG0084	hydrolase, TatD family'
HEP74_00343	COG0842	Transport permease protein
HEP74_00344	COG1131	(ABC) transporter
HEP74_00345	COG0633	Ferredoxin
HEP74_00345	COG0543	2 iron, 2 sulfur cluster binding
HEP74_00346	COG2207	Transcriptional regulator
HEP74_00346	COG0662	Cupin 2, conserved barrel domain protein
HEP74_00349	COG1476	TRANSCRIPTIONal
HEP74_00351	COG4555	ABC transporter
HEP74_00355	COG0625	glutathione transferase activity
HEP74_00362	COG0028	Belongs to the TPP enzyme family
HEP74_00368	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP74_00372	COG1199	ATP-dependent helicase activity
HEP74_00386	COG0628	permease
HEP74_00392	COG2133	pyrroloquinoline quinone binding
HEP74_00399	COG5463	Belongs to the UPF0441 family
HEP74_00400	COG0754	glutathionylspermidine amidase activity
HEP74_00410	COG2831	hemolysin activation secretion protein
HEP74_00412	COG0714	Associated with various cellular activities
HEP74_00419	COG1522	sequence-specific DNA binding
HEP74_00420	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEP74_00423	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_00424	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP74_00428	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEP74_00432	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_00436	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HEP74_00438	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP74_00441	COG2267	carboxylic ester hydrolase activity
HEP74_00442	COG0606	chelatase, subunit chli
HEP74_00443	COG2960	long-chain fatty acid transporting porin activity
HEP74_00448	COG1166	arginine decarboxylase activity
HEP74_00449	COG2755	lipolytic protein G-D-S-L family
HEP74_00449	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP74_00451	COG0583	DNA-binding transcription factor activity
HEP74_00455	COG4221	oxidoreductase activity
HEP74_00459	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEP74_00461	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP74_00463	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEP74_00465	COG2814	Major facilitator Superfamily
HEP74_00468	COG0739	heme binding
HEP74_00469	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEP74_00473	COG1064	alcohol dehydrogenase
HEP74_00474	COG2234	aminopeptidase activity
HEP74_00476	COG4942	peptidase
HEP74_00477	COG0793	Belongs to the peptidase S41A family
HEP74_00483	COG0531	amino acid
HEP74_00485	COG1486	melibiose metabolic process
HEP74_00488	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEP74_00488	COG1565	acr, cog1565
HEP74_00491	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HEP74_00492	COG1845	cytochrome c oxidase, subunit III
HEP74_00496	COG1612	heme a metabolic process
HEP74_00497	COG0109	protoheme IX farnesyltransferase activity
HEP74_00501	COG0358	DNA primase activity
HEP74_00502	COG1295	ribonuclease BN
HEP74_00503	COG1610	YqeY-like protein
HEP74_00506	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEP74_00507	COG2308	Evidence 4 Homologs of previously reported genes of
HEP74_00510	COG2133	pyrroloquinoline quinone binding
HEP74_00514	COG0531	amino acid
HEP74_00516	COG4948	Mandelate Racemase Muconate Lactonizing
HEP74_00518	COG4771	TonB-dependent receptor
HEP74_00525	COG3501	Rhs element vgr protein
HEP74_00525	COG3409	Peptidoglycan-binding domain 1 protein
HEP74_00526	COG0583	DNA-binding transcription factor activity
HEP74_00527	COG0477	Major facilitator Superfamily
HEP74_00535	COG5383	Protein conserved in bacteria
HEP74_00539	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_00542	COG1652	LysM domain
HEP74_00547	COG0583	DNA-binding transcription factor activity
HEP74_00551	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HEP74_00552	COG3118	belongs to the thioredoxin family
HEP74_00554	COG2884	Cell division ATP-binding protein ftsE
HEP74_00555	COG2177	Part of the ABC transporter FtsEX involved in
HEP74_00556	COG2201	protein-glutamate methylesterase activity
HEP74_00557	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEP74_00558	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP74_00559	COG2860	membrane
HEP74_00560	COG1252	NADH dehydrogenase
HEP74_00562	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HEP74_00564	COG0534	Mate efflux family protein
HEP74_00565	COG0616	signal peptide processing
HEP74_00567	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_00570	COG0009	L-threonylcarbamoyladenylate synthase
HEP74_00571	COG1754	DNA topoisomerase type I activity
HEP74_00571	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEP74_00572	COG1714	RDD family
HEP74_00575	COG0758	DNA mediated transformation
HEP74_00576	COG1652	LysM domain
HEP74_00577	COG0242	peptide deformylase activity
HEP74_00579	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HEP74_00579	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP74_00580	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP74_00583	COG0463	Glycosyl transferase, family 2
HEP74_00587	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP74_00590	COG1490	D-aminoacyl-tRNA deacylase activity
HEP74_00591	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP74_00594	COG1609	Transcriptional regulator
HEP74_00595	COG3537	Alpha-1,2-mannosidase
HEP74_00596	COG1733	regulation of RNA biosynthetic process
HEP74_00598	COG0366	Alpha amylase catalytic
HEP74_00599	COG0366	Alpha amylase catalytic
HEP74_00600	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP74_00602	COG1002	Type II restriction enzyme, methylase subunits
HEP74_00603	COG1061	Type III restriction enzyme res subunit
HEP74_00604	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP74_00612	COG1309	transcriptional regulator
HEP74_00613	COG0604	alcohol dehydrogenase
HEP74_00616	COG0024	Methionine aminopeptidase
HEP74_00621	COG4773	Receptor
HEP74_00623	COG2207	Transcriptional regulator
HEP74_00625	COG1309	transcriptional regulator
HEP74_00630	COG2124	cytochrome p450
HEP74_00630	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP74_00631	COG1309	transcriptional regulator
HEP74_00633	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP74_00634	COG2271	Major facilitator Superfamily
HEP74_00639	COG0745	RESPONSE REGULATOR receiver
HEP74_00640	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HEP74_00640	COG4932	domain protein
HEP74_00640	COG3266	domain, Protein
HEP74_00644	COG0840	transmembrane signaling receptor activity
HEP74_00648	COG3546	catalase activity
HEP74_00649	COG3685	Protein conserved in bacteria
HEP74_00650	COG3685	Protein conserved in bacteria
HEP74_00651	COG0588	phosphoglycerate mutase activity
HEP74_00652	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEP74_00653	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_00655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP74_00662	COG0028	Belongs to the TPP enzyme family
HEP74_00663	COG4191	Histidine kinase
HEP74_00664	COG2204	response regulator
HEP74_00668	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP74_00668	COG1648	precorrin-2 dehydrogenase activity
HEP74_00670	COG1116	anion transmembrane transporter activity
HEP74_00670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEP74_00676	COG2223	nitrite transmembrane transporter activity
HEP74_00677	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP74_00678	COG2146	nitrite reductase [NAD(P)H] activity
HEP74_00679	COG0243	molybdopterin cofactor binding
HEP74_00685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP74_00687	COG0297	glycogen (starch) synthase activity
HEP74_00689	COG0745	RESPONSE REGULATOR receiver
HEP74_00691	COG1335	isochorismatase
HEP74_00696	COG0181	hydroxymethylbilane synthase activity
HEP74_00699	COG1733	regulation of RNA biosynthetic process
HEP74_00702	COG1505	serine-type exopeptidase activity
HEP74_00703	COG0436	Aminotransferase
HEP74_00705	COG2832	Protein of unknown function (DUF454)
HEP74_00712	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HEP74_00713	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HEP74_00714	COG0366	Alpha amylase catalytic
HEP74_00717	COG3345	alpha-galactosidase
HEP74_00719	COG2222	sugar isomerase
HEP74_00724	COG1349	DNA-binding transcription factor activity
HEP74_00739	COG3250	beta-galactosidase activity
HEP74_00742	COG2188	Transcriptional regulator
HEP74_00744	COG1609	Transcriptional regulator
HEP74_00745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP74_00746	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEP74_00747	COG3001	Fructosamine kinase
HEP74_00752	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP74_00755	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HEP74_00757	COG2207	Transcriptional regulator
HEP74_00761	COG3738	Protein conserved in bacteria
HEP74_00765	COG2205	protein histidine kinase activity
HEP74_00769	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEP74_00770	COG3791	Glutathione-dependent formaldehyde-activating
HEP74_00773	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP74_00775	COG0697	spore germination
HEP74_00777	COG1307	EDD domain protein, DegV family
HEP74_00780	COG0804	urea catabolic process
HEP74_00781	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP74_00784	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEP74_00789	COG0436	Aminotransferase
HEP74_00790	COG1162	GTPase activity
HEP74_00795	COG2211	Major facilitator Superfamily
HEP74_00797	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_00798	COG2851	Citrate transporter
HEP74_00801	COG0642	Histidine kinase
HEP74_00803	COG3292	Two component regulator propeller
HEP74_00803	COG2205	protein histidine kinase activity
HEP74_00803	COG3292	Two component regulator propeller
HEP74_00803	COG0745	RESPONSE REGULATOR receiver
HEP74_00803	COG0745	RESPONSE REGULATOR receiver
HEP74_00803	COG2205	protein histidine kinase activity
HEP74_00806	COG4191	Histidine kinase
HEP74_00808	COG1301	dicarboxylic acid transport
HEP74_00809	COG0280	phosphate acetyltransferase
HEP74_00809	COG0281	malic enzyme
HEP74_00814	COG1560	Kdo2-lipid A biosynthetic process
HEP74_00815	COG1519	Transferase
HEP74_00816	COG1538	Outer membrane efflux protein
HEP74_00817	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP74_00821	COG0473	3-isopropylmalate dehydrogenase activity
HEP74_00822	COG0066	3-isopropylmalate dehydratase activity
HEP74_00825	COG4106	trans-aconitate 2-methyltransferase activity
HEP74_00826	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP74_00830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEP74_00832	COG2815	serine threonine protein kinase
HEP74_00832	COG0515	serine threonine protein kinase
HEP74_00833	COG0405	Gamma-glutamyltransferase
HEP74_00834	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HEP74_00835	COG0840	transmembrane signaling receptor activity
HEP74_00838	COG0823	Involved in the tonB-independent uptake of proteins
HEP74_00842	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HEP74_00844	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HEP74_00851	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEP74_00853	COG0671	phosphoesterase, PA-phosphatase related
HEP74_00856	COG1940	carbohydrate kinase activity
HEP74_00857	COG0346	lactoylglutathione lyase activity
HEP74_00858	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP74_00859	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP74_00861	COG4206	TonB-dependent receptor
HEP74_00863	COG2010	Cytochrome c
HEP74_00865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP74_00866	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HEP74_00867	COG2909	trisaccharide binding
HEP74_00868	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEP74_00871	COG1773	rubredoxin
HEP74_00876	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEP74_00881	COG3079	Belongs to the UPF0149 family
HEP74_00882	COG0006	proline dipeptidase activity
HEP74_00883	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP74_00886	COG5002	protein histidine kinase activity
HEP74_00887	COG3038	cytochrome b561
HEP74_00888	COG1309	transcriptional regulator
HEP74_00889	COG0006	proline dipeptidase activity
HEP74_00892	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEP74_00893	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEP74_00894	COG0346	lactoylglutathione lyase activity
HEP74_00895	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HEP74_00896	COG1561	YicC-like family, N-terminal region
HEP74_00897	COG0194	GDP metabolic process
HEP74_00898	COG1758	RNA polymerase activity
HEP74_00899	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP74_00901	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEP74_00903	COG0254	rRNA binding
HEP74_00904	COG0372	Belongs to the citrate synthase family
HEP74_00907	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEP74_00913	COG3293	Transposase
HEP74_00915	COG0714	Associated with various cellular activities
HEP74_00922	COG1301	dicarboxylic acid transport
HEP74_00923	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEP74_00928	COG0739	heme binding
HEP74_00929	COG1376	ErfK ybiS ycfS ynhG family protein
HEP74_00937	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HEP74_00938	COG4149	molybdate abc transporter
HEP74_00939	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEP74_00941	COG0640	Transcriptional regulator
HEP74_00947	COG3591	Belongs to the peptidase S1B family
HEP74_00953	COG3047	cAMP biosynthetic process
HEP74_00954	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEP74_00957	COG4221	oxidoreductase activity
HEP74_00958	COG4221	oxidoreductase activity
HEP74_00960	COG0604	alcohol dehydrogenase
HEP74_00960	COG3321	synthase
HEP74_00961	COG0840	transmembrane signaling receptor activity
HEP74_00966	COG0469	pyruvate kinase activity
HEP74_00967	COG3588	fructose-bisphosphate aldolase
HEP74_00969	COG2205	protein histidine kinase activity
HEP74_00972	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HEP74_00981	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HEP74_00985	COG2072	flavoprotein involved in K transport
HEP74_00986	COG2351	hydroxyisourate hydrolase activity
HEP74_00988	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP74_00992	COG1648	precorrin-2 dehydrogenase activity
HEP74_00992	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP74_00995	COG0784	Response regulator, receiver
HEP74_00995	COG2205	protein histidine kinase activity
HEP74_00995	COG2198	Histidine kinase
HEP74_00996	COG0431	NADPH-dependent FMN reductase
HEP74_00997	COG1393	Belongs to the ArsC family
HEP74_01002	COG0175	sulfate reduction
HEP74_01003	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP74_01004	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP74_01006	COG0529	Catalyzes the synthesis of activated sulfate
HEP74_01006	COG2895	sulfate adenylyltransferase (ATP) activity
HEP74_01008	COG0438	transferase activity, transferring glycosyl groups
HEP74_01012	COG1115	amino acid carrier protein
HEP74_01014	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP74_01019	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP74_01022	COG3273	potassium ion transport
HEP74_01022	COG0471	metal ion transport
HEP74_01024	COG2022	thiamine diphosphate biosynthetic process
HEP74_01029	COG3511	phospholipase C
HEP74_01031	COG0189	ligase activity
HEP74_01033	COG0745	RESPONSE REGULATOR receiver
HEP74_01036	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HEP74_01044	COG4993	Dehydrogenase
HEP74_01045	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEP74_01045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP74_01047	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEP74_01049	COG1174	glycine betaine transport
HEP74_01050	COG1125	glycine betaine transport
HEP74_01052	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP74_01053	COG0564	pseudouridine synthase activity
HEP74_01057	COG0840	transmembrane signaling receptor activity
HEP74_01058	COG4993	Dehydrogenase
HEP74_01060	COG3387	PFAM Glycoside hydrolase 15-related
HEP74_01064	COG4771	TonB-dependent receptor
HEP74_01066	COG0454	-acetyltransferase
HEP74_01071	COG0542	response to heat
HEP74_01076	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_01077	COG1733	regulation of RNA biosynthetic process
HEP74_01079	COG2223	nitrite transmembrane transporter activity
HEP74_01081	COG0019	diaminopimelate decarboxylase activity
HEP74_01082	COG4264	IucA IucC family
HEP74_01083	COG2814	Major facilitator Superfamily
HEP74_01084	COG4264	IucA IucC family
HEP74_01086	COG4772	TonB-dependent receptor
HEP74_01088	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP74_01088	COG4651	solute:proton antiporter activity
HEP74_01094	COG0488	(ABC) transporter
HEP74_01100	COG0657	acetylesterase activity
HEP74_01100	COG2755	lipolytic protein G-D-S-L family
HEP74_01102	COG4774	siderophore transport
HEP74_01110	COG0217	transcriptional regulatory protein
HEP74_01112	COG0632	four-way junction helicase activity
HEP74_01115	COG0824	Thioesterase
HEP74_01117	COG0848	biopolymer transport protein
HEP74_01119	COG0823	Involved in the tonB-independent uptake of proteins
HEP74_01120	COG2885	chlorophyll binding
HEP74_01122	COG0602	queuosine metabolic process
HEP74_01123	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HEP74_01130	COG0514	ATP-dependent DNA helicase (RecQ)
HEP74_01132	COG0783	Belongs to the Dps family
HEP74_01133	COG1643	Atp-dependent helicase
HEP74_01140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP74_01142	COG1216	Glycosyl transferase, family 2
HEP74_01143	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP74_01145	COG1199	ATP-dependent helicase activity
HEP74_01147	COG1397	ADP-ribosylglycohydrolase
HEP74_01150	COG0189	ligase activity
HEP74_01153	COG0835	chemotaxis
HEP74_01154	COG0840	transmembrane signaling receptor activity
HEP74_01155	COG0784	Response regulator, receiver
HEP74_01155	COG2198	Histidine kinase
HEP74_01155	COG0643	Histidine kinase
HEP74_01156	COG2201	protein-glutamate methylesterase activity
HEP74_01159	COG1446	asparaginase
HEP74_01171	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
HEP74_01175	COG0583	DNA-binding transcription factor activity
HEP74_01179	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP74_01181	COG1595	DNA-templated transcription, initiation
HEP74_01189	COG3537	Alpha-1,2-mannosidase
HEP74_01191	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP74_01193	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HEP74_01194	COG3858	chitin binding
HEP74_01194	COG1388	LysM domain
HEP74_01198	COG0837	glucose binding
HEP74_01200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HEP74_01202	COG0494	nUDIX hydrolase
HEP74_01204	COG3956	TIGRFAM MazG family protein
HEP74_01205	COG1742	UPF0060 membrane protein
HEP74_01207	COG0330	HflC and HflK could
HEP74_01214	COG0697	spore germination
HEP74_01219	COG1960	acyl-CoA dehydrogenase activity
HEP74_01224	COG0457	Tetratricopeptide repeat
HEP74_01227	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HEP74_01228	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP74_01229	COG0463	Glycosyl transferase, family 2
HEP74_01230	COG0517	IMP dehydrogenase activity
HEP74_01231	COG2982	Protein involved in outer membrane biogenesis
HEP74_01232	COG1272	protein, Hemolysin III
HEP74_01233	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HEP74_01235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP74_01236	COG0626	cystathionine gamma-synthase activity
HEP74_01237	COG0527	aspartate kinase activity
HEP74_01237	COG0460	homoserine dehydrogenase
HEP74_01240	COG1760	l-serine dehydratase
HEP74_01243	COG3038	cytochrome b561
HEP74_01247	COG0477	Major facilitator Superfamily
HEP74_01248	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HEP74_01251	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEP74_01265	COG3706	GGDEF domain
HEP74_01273	COG0519	Catalyzes the synthesis of GMP from XMP
HEP74_01276	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEP74_01283	COG1113	amino acid transport
HEP74_01287	COG2239	Acts as a magnesium transporter
HEP74_01288	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP74_01289	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP74_01291	COG1660	Displays ATPase and GTPase activities
HEP74_01293	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP74_01296	COG1137	ATPase activity
HEP74_01299	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HEP74_01306	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEP74_01311	COG0628	permease
HEP74_01313	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP74_01314	COG3178	'Phosphotransferase
HEP74_01317	COG1555	photosystem II stabilization
HEP74_01322	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP74_01323	COG1477	protein flavinylation
HEP74_01328	COG4774	siderophore transport
HEP74_01329	COG2146	nitrite reductase [NAD(P)H] activity
HEP74_01331	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP74_01332	COG0719	Fe-S assembly protein
HEP74_01333	COG0396	ATPase activity
HEP74_01334	COG0719	Fe-S assembly protein
HEP74_01337	COG0693	protein deglycase activity
HEP74_01340	COG0739	heme binding
HEP74_01343	COG1764	response to oxidative stress
HEP74_01345	COG0384	phenazine biosynthesis protein PhzF
HEP74_01346	COG0527	aspartate kinase activity
HEP74_01351	COG0142	geranyltranstransferase activity
HEP74_01352	COG0629	single-stranded DNA binding
HEP74_01354	COG1858	cytochrome C peroxidase
HEP74_01360	COG4615	Cyclic peptide transporter
HEP74_01365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_01366	COG1136	(ABC) transporter
HEP74_01366	COG0577	efflux transmembrane transporter activity
HEP74_01367	COG1136	(ABC) transporter
HEP74_01367	COG0577	efflux transmembrane transporter activity
HEP74_01370	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HEP74_01375	COG2010	Cytochrome c
HEP74_01377	COG0673	inositol 2-dehydrogenase activity
HEP74_01378	COG2211	Major facilitator Superfamily
HEP74_01380	COG1609	Transcriptional regulator
HEP74_01383	COG3104	oligopeptide transport
HEP74_01384	COG1297	OPT oligopeptide transporter protein
HEP74_01385	COG1506	peptidase
HEP74_01385	COG0823	Involved in the tonB-independent uptake of proteins
HEP74_01389	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP74_01390	COG2879	small protein
HEP74_01391	COG1966	Carbon starvation protein
HEP74_01392	COG1741	Belongs to the pirin family
HEP74_01394	COG1741	Belongs to the pirin family
HEP74_01400	COG2211	Major facilitator Superfamily
HEP74_01402	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEP74_01405	COG4251	negative regulation of phosphorylation
HEP74_01405	COG5001	Diguanylate cyclase
HEP74_01405	COG2203	Gaf domain
HEP74_01405	COG3706	GGDEF domain
HEP74_01406	COG0835	chemotaxis
HEP74_01407	COG0840	transmembrane signaling receptor activity
HEP74_01409	COG0840	transmembrane signaling receptor activity
HEP74_01410	COG2198	Histidine kinase
HEP74_01410	COG0643	Histidine kinase
HEP74_01412	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HEP74_01415	COG3878	Protein conserved in bacteria
HEP74_01416	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HEP74_01418	COG0642	Histidine kinase
HEP74_01419	COG3111	PFAM Bacterial OB fold (BOF) protein
HEP74_01420	COG0745	RESPONSE REGULATOR receiver
HEP74_01421	COG2205	protein histidine kinase activity
HEP74_01422	COG4452	Inner membrane protein CreD
HEP74_01427	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP74_01428	COG0735	belongs to the Fur family
HEP74_01434	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP74_01436	COG1309	transcriptional regulator
HEP74_01439	COG3214	Protein conserved in bacteria
HEP74_01443	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP74_01444	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEP74_01445	COG2080	2 iron, 2 sulfur cluster binding
HEP74_01452	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEP74_01465	COG1187	pseudouridine synthase activity
HEP74_01470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP74_01471	COG3795	YCII-related domain
HEP74_01475	COG4941	Belongs to the sigma-70 factor family
HEP74_01480	COG1132	(ABC) transporter
HEP74_01487	COG0583	DNA-binding transcription factor activity
HEP74_01496	COG1981	membrane
HEP74_01498	COG0825	malonyl-CoA metabolic process
HEP74_01501	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP74_01502	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP74_01506	COG0750	zinc metalloprotease
HEP74_01507	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HEP74_01508	COG0575	Belongs to the CDS family
HEP74_01509	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEP74_01511	COG0528	UMP kinase activity
HEP74_01513	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEP74_01521	COG0024	Methionine aminopeptidase
HEP74_01524	COG1393	Belongs to the ArsC family
HEP74_01525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP74_01526	COG0367	asparagine synthase
HEP74_01536	COG1566	PFAM secretion protein HlyD family protein
HEP74_01537	COG2814	Major facilitator Superfamily
HEP74_01545	COG0557	exoribonuclease II activity
HEP74_01547	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP74_01550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP74_01554	COG0704	Plays a role in the regulation of phosphate uptake
HEP74_01556	COG0581	inorganic phosphate transmembrane transporter activity
HEP74_01559	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP74_01563	COG0659	secondary active sulfate transmembrane transporter activity
HEP74_01564	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HEP74_01566	COG1024	Enoyl-CoA hydratase
HEP74_01575	COG0488	(ABC) transporter
HEP74_01578	COG5002	protein histidine kinase activity
HEP74_01578	COG0784	Response regulator, receiver
HEP74_01578	COG2205	protein histidine kinase activity
HEP74_01579	COG2733	membrane
HEP74_01587	COG0686	Belongs to the AlaDH PNT family
HEP74_01588	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP74_01589	COG1917	Cupin 2, conserved barrel domain protein
HEP74_01589	COG1396	sequence-specific DNA binding
HEP74_01590	COG1012	belongs to the aldehyde dehydrogenase family
HEP74_01594	COG0243	molybdopterin cofactor binding
HEP74_01596	COG0477	Major facilitator Superfamily
HEP74_01598	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP74_01599	COG0174	glutamine synthetase
HEP74_01600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HEP74_01601	COG0174	glutamine synthetase
HEP74_01603	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP74_01604	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP74_01608	COG3842	ATPase activity
HEP74_01609	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEP74_01610	COG1177	transmembrane transport
HEP74_01611	COG1012	belongs to the aldehyde dehydrogenase family
HEP74_01612	COG0598	Magnesium transport protein CorA
HEP74_01614	COG4535	Mg2 and Co2 transporter CorC
HEP74_01619	COG1702	phosphate starvation-inducible protein PhoH
HEP74_01625	COG0741	lytic transglycosylase activity
HEP74_01626	COG0723	plastoquinol--plastocyanin reductase activity
HEP74_01627	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP74_01629	COG2857	Cytochrome c1
HEP74_01630	COG0625	glutathione transferase activity
HEP74_01631	COG2969	positive regulation of protein catabolic process
HEP74_01639	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEP74_01640	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_01641	COG2095	MarC family integral membrane protein
HEP74_01644	COG1611	Belongs to the LOG family
HEP74_01645	COG3275	phosphorelay sensor kinase activity
HEP74_01654	COG0556	nucleotide-excision repair
HEP74_01661	COG2948	multi-organism process
HEP74_01669	COG0366	Alpha amylase catalytic
HEP74_01671	COG1082	Xylose isomerase domain protein TIM barrel
HEP74_01680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEP74_01682	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEP74_01683	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEP74_01684	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP74_01684	COG0072	phenylalanine-tRNA ligase activity
HEP74_01693	COG0438	transferase activity, transferring glycosyl groups
HEP74_01694	COG0438	transferase activity, transferring glycosyl groups
HEP74_01696	COG0438	transferase activity, transferring glycosyl groups
HEP74_01701	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEP74_01703	COG1960	acyl-CoA dehydrogenase activity
HEP74_01707	COG1846	Transcriptional regulator
HEP74_01714	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HEP74_01715	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HEP74_01715	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEP74_01716	COG0802	atpase or kinase
HEP74_01717	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEP74_01718	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HEP74_01722	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_01726	COG2081	HI0933 family
HEP74_01727	COG4681	YaeQ
HEP74_01728	COG0564	pseudouridine synthase activity
HEP74_01730	COG0625	glutathione transferase activity
HEP74_01731	COG0657	acetylesterase activity
HEP74_01738	COG0513	Belongs to the DEAD box helicase family
HEP74_01741	COG0488	(ABC) transporter
HEP74_01746	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HEP74_01747	COG2207	Transcriptional regulator
HEP74_01750	COG2197	response regulator
HEP74_01752	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP74_01759	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP74_01760	COG1846	Transcriptional regulator
HEP74_01761	COG0339	signal peptide processing
HEP74_01762	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP74_01763	COG0386	Belongs to the glutathione peroxidase family
HEP74_01769	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP74_01778	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HEP74_01783	COG0084	hydrolase, TatD family'
HEP74_01786	COG1960	acyl-CoA dehydrogenase activity
HEP74_01789	COG0305	Participates in initiation and elongation during chromosome replication
HEP74_01792	COG2204	response regulator
HEP74_01794	COG0415	Belongs to the DNA photolyase family
HEP74_01797	COG0583	DNA-binding transcription factor activity
HEP74_01800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_01804	COG3706	GGDEF domain
HEP74_01805	COG0583	DNA-binding transcription factor activity
HEP74_01809	COG1404	Belongs to the peptidase S8 family
HEP74_01810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HEP74_01813	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP74_01814	COG0735	belongs to the Fur family
HEP74_01815	COG0497	DNA recombination
HEP74_01816	COG1420	regulation of RNA biosynthetic process
HEP74_01817	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP74_01818	COG0443	Heat shock 70 kDa protein
HEP74_01819	COG0484	heat shock protein binding
HEP74_01822	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HEP74_01823	COG1605	Chorismate mutase
HEP74_01823	COG0287	Prephenate dehydrogenase
HEP74_01825	COG1132	(ABC) transporter
HEP74_01836	COG2850	peptidyl-arginine hydroxylation
HEP74_01837	COG2885	chlorophyll binding
HEP74_01846	COG1131	(ABC) transporter
HEP74_01847	COG1725	Transcriptional regulator
HEP74_01849	COG0386	Belongs to the glutathione peroxidase family
HEP74_01852	COG2900	Belongs to the SlyX family
HEP74_01856	COG0646	methionine synthase
HEP74_01856	COG1410	methionine synthase
HEP74_01857	COG0646	methionine synthase
HEP74_01857	COG1410	methionine synthase
HEP74_01858	COG2226	methyltransferase
HEP74_01859	COG1960	acyl-CoA dehydrogenase activity
HEP74_01860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP74_01861	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_01863	COG2902	Dehydrogenase
HEP74_01870	COG2925	Exonuclease
HEP74_01872	COG3844	kynureninase activity
HEP74_01873	COG1289	transmembrane transporter activity
HEP74_01875	COG0288	reversible hydration of carbon dioxide
HEP74_01884	COG2197	response regulator
HEP74_01890	COG0316	Belongs to the HesB IscA family
HEP74_01891	COG2977	Belongs to the P-Pant transferase superfamily
HEP74_01897	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP74_01898	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP74_01899	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HEP74_01903	COG4993	Dehydrogenase
HEP74_01912	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HEP74_01918	COG4221	oxidoreductase activity
HEP74_01925	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HEP74_01926	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP74_01927	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HEP74_01928	COG0077	Prephenate dehydratase
HEP74_01928	COG1605	Chorismate mutase
HEP74_01933	COG0583	DNA-binding transcription factor activity
HEP74_01936	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP74_01939	COG1530	ribonuclease E activity
HEP74_01941	COG3064	Membrane
HEP74_01942	COG0428	transporter
HEP74_01945	COG0316	Belongs to the HesB IscA family
HEP74_01945	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HEP74_01949	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_01953	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP74_01954	COG2957	Belongs to the agmatine deiminase family
HEP74_01957	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HEP74_01958	COG0539	negative regulation of cytoplasmic translation
HEP74_01959	COG0776	regulation of translation
HEP74_01961	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HEP74_01964	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEP74_01965	COG0183	Belongs to the thiolase family
HEP74_01966	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP74_01966	COG1024	Enoyl-CoA hydratase
HEP74_01969	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HEP74_01971	COG1426	Protein conserved in bacteria
HEP74_01973	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP74_01975	COG0746	molybdenum cofactor guanylyltransferase activity
HEP74_01977	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEP74_01978	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP74_01978	COG0475	glutathione-regulated potassium exporter activity
HEP74_01982	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP74_01984	COG0519	Catalyzes the synthesis of GMP from XMP
HEP74_01984	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP74_01987	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_01991	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP74_01993	COG1309	transcriptional regulator
HEP74_01994	COG1538	Outer membrane efflux protein
HEP74_01995	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP74_01996	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP74_01997	COG4191	Histidine kinase
HEP74_01997	COG0784	Response regulator, receiver
HEP74_01999	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HEP74_02001	COG1914	H( )-stimulated, divalent metal cation uptake system
HEP74_02004	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HEP74_02005	COG0668	transmembrane transport
HEP74_02010	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_02011	COG1183	phosphatidylcholine synthase activity
HEP74_02013	COG3243	poly(R)-hydroxyalkanoic acid synthase
HEP74_02017	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HEP74_02017	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP74_02019	COG4191	Histidine kinase
HEP74_02019	COG0784	Response regulator, receiver
HEP74_02020	COG2183	response to ionizing radiation
HEP74_02021	COG2205	protein histidine kinase activity
HEP74_02021	COG0784	Response regulator, receiver
HEP74_02030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_02034	COG5000	phosphorelay sensor kinase activity
HEP74_02034	COG5002	protein histidine kinase activity
HEP74_02036	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_02044	COG2197	response regulator
HEP74_02045	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_02047	COG1335	isochorismatase
HEP74_02048	COG4585	Histidine kinase
HEP74_02051	COG0714	Associated with various cellular activities
HEP74_02053	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HEP74_02057	COG1136	(ABC) transporter
HEP74_02057	COG0577	efflux transmembrane transporter activity
HEP74_02068	COG1132	(ABC) transporter
HEP74_02072	COG0438	transferase activity, transferring glycosyl groups
HEP74_02073	COG0297	glycogen (starch) synthase activity
HEP74_02077	COG2226	methyltransferase
HEP74_02081	COG2244	polysaccharide biosynthetic process
HEP74_02087	COG3038	cytochrome b561
HEP74_02091	COG1595	DNA-templated transcription, initiation
HEP74_02106	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP74_02107	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HEP74_02108	COG1230	cation diffusion facilitator family transporter
HEP74_02111	COG1674	ftsk spoiiie
HEP74_02112	COG0492	ferredoxin-NADP+ reductase activity
HEP74_02116	COG0542	response to heat
HEP74_02120	COG0482	sulfurtransferase activity
HEP74_02121	COG2915	High frequency lysogenization protein hflD homolog
HEP74_02124	COG1116	anion transmembrane transporter activity
HEP74_02133	COG0784	Response regulator, receiver
HEP74_02133	COG0835	chemotaxis
HEP74_02135	COG1558	bacterial-type flagellum-dependent cell motility
HEP74_02136	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HEP74_02137	COG1749	Flagellar hook protein flgE
HEP74_02140	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HEP74_02143	COG4786	Flagellar basal body rod
HEP74_02143	COG1256	bacterial-type flagellum assembly
HEP74_02144	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HEP74_02146	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HEP74_02150	COG2197	response regulator
HEP74_02152	COG2201	protein-glutamate methylesterase activity
HEP74_02156	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP74_02157	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_02158	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_02165	COG1677	Flagellar hook-basal body complex protein FliE
HEP74_02175	COG3190	flagellar
HEP74_02177	COG1987	bacterial-type flagellum assembly
HEP74_02178	COG1684	flagellar biosynthetic protein fliR
HEP74_02188	COG0643	Histidine kinase
HEP74_02188	COG0784	Response regulator, receiver
HEP74_02188	COG2198	Histidine kinase
HEP74_02189	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HEP74_02191	COG1192	Involved in chromosome partitioning
HEP74_02194	COG0745	RESPONSE REGULATOR receiver
HEP74_02196	COG0840	transmembrane signaling receptor activity
HEP74_02197	COG0840	transmembrane signaling receptor activity
HEP74_02198	COG0840	transmembrane signaling receptor activity
HEP74_02200	COG0840	transmembrane signaling receptor activity
HEP74_02201	COG0840	transmembrane signaling receptor activity
HEP74_02202	COG0840	transmembrane signaling receptor activity
HEP74_02203	COG0840	transmembrane signaling receptor activity
HEP74_02205	COG0840	transmembrane signaling receptor activity
HEP74_02206	COG0840	transmembrane signaling receptor activity
HEP74_02208	COG0835	chemotaxis
HEP74_02210	COG0840	transmembrane signaling receptor activity
HEP74_02213	COG0840	transmembrane signaling receptor activity
HEP74_02224	COG0318	PFAM AMP-dependent synthetase and ligase
HEP74_02225	COG1024	Enoyl-CoA hydratase
HEP74_02226	COG2198	Histidine kinase
HEP74_02226	COG2205	protein histidine kinase activity
HEP74_02226	COG0784	Response regulator, receiver
HEP74_02229	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEP74_02230	COG3279	Response regulator of the LytR AlgR family
HEP74_02231	COG4676	Protein conserved in bacteria
HEP74_02234	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP74_02235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEP74_02237	COG0505	Belongs to the CarA family
HEP74_02239	COG2258	MOSC domain
HEP74_02240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP74_02247	COG1024	Enoyl-CoA hydratase
HEP74_02251	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEP74_02255	COG0277	FAD linked oxidase domain protein
HEP74_02256	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEP74_02259	COG0531	amino acid
HEP74_02260	COG0531	amino acid
HEP74_02261	COG0235	Class ii aldolase
HEP74_02262	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HEP74_02263	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HEP74_02266	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEP74_02266	COG0140	phosphoribosyl-ATP diphosphatase activity
HEP74_02269	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEP74_02272	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEP74_02273	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HEP74_02275	COG0124	histidyl-tRNA synthetase
HEP74_02276	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP74_02278	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEP74_02280	COG0460	homoserine dehydrogenase
HEP74_02280	COG0527	aspartate kinase activity
HEP74_02284	COG1012	belongs to the aldehyde dehydrogenase family
HEP74_02289	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEP74_02293	COG1794	racemase activity, acting on amino acids and derivatives
HEP74_02294	COG0671	phosphoesterase, PA-phosphatase related
HEP74_02297	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HEP74_02301	COG0166	Belongs to the GPI family
HEP74_02304	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HEP74_02306	COG0617	tRNA 3'-terminal CCA addition
HEP74_02310	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEP74_02311	COG0477	Major facilitator Superfamily
HEP74_02312	COG2115	Belongs to the xylose isomerase family
HEP74_02313	COG1070	Carbohydrate kinase
HEP74_02315	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP74_02322	COG0800	Aldolase
HEP74_02325	COG3734	2-keto-3-deoxy-galactonokinase
HEP74_02326	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HEP74_02328	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP74_02330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEP74_02331	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HEP74_02334	COG0352	thiamine-phosphate diphosphorylase activity
HEP74_02334	COG0351	phosphomethylpyrimidine kinase
HEP74_02339	COG0583	DNA-binding transcription factor activity
HEP74_02340	COG1741	Belongs to the pirin family
HEP74_02343	COG0194	GDP metabolic process
HEP74_02346	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HEP74_02347	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEP74_02348	COG2137	regulation of response to DNA damage stimulus
HEP74_02349	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HEP74_02350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP74_02351	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP74_02352	COG1546	Belongs to the CinA family
HEP74_02353	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEP74_02356	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEP74_02357	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP74_02359	COG1534	Rna-binding protein
HEP74_02362	COG1238	metal cluster binding
HEP74_02364	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HEP74_02367	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HEP74_02368	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HEP74_02369	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HEP74_02373	COG0504	CTP synthase activity
HEP74_02377	COG0306	phosphate transporter
HEP74_02379	COG1253	flavin adenine dinucleotide binding
HEP74_02382	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP74_02389	COG0069	glutamate synthase activity
HEP74_02390	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HEP74_02393	COG1609	Transcriptional regulator
HEP74_02394	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP74_02394	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP74_02395	COG1105	Belongs to the carbohydrate kinase PfkB family
HEP74_02396	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP74_02396	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP74_02403	COG1136	(ABC) transporter
HEP74_02403	COG0577	efflux transmembrane transporter activity
HEP74_02412	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP74_02414	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEP74_02415	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HEP74_02417	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEP74_02419	COG0348	domain, Protein
HEP74_02427	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP74_02428	COG0322	excinuclease ABC activity
HEP74_02430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP74_02433	COG1663	tetraacyldisaccharide 4'-kinase activity
HEP74_02434	COG1132	(ABC) transporter
HEP74_02436	COG0811	peptide transport
HEP74_02437	COG2333	competence protein COMEC
HEP74_02437	COG0658	competence protein
HEP74_02440	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEP74_02445	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HEP74_02447	COG0354	folic acid binding
HEP74_02448	COG3842	ATPase activity
HEP74_02449	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEP74_02452	COG0129	dihydroxy-acid dehydratase activity
HEP74_02453	COG0800	Aldolase
HEP74_02455	COG0395	ABC-type sugar transport system, permease component
HEP74_02463	COG2350	Protein conserved in bacteria
HEP74_02464	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HEP74_02465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HEP74_02466	COG1187	pseudouridine synthase activity
HEP74_02471	COG0436	Aminotransferase
HEP74_02472	COG4133	protoheme IX ABC transporter activity
HEP74_02476	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HEP74_02482	COG1278	Cold shock
HEP74_02483	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HEP74_02484	COG4988	ABC transporter
HEP74_02486	COG1294	oxidase, subunit
HEP74_02492	COG1064	alcohol dehydrogenase
HEP74_02496	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEP74_02500	COG0165	Argininosuccinate lyase
HEP74_02501	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEP74_02503	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEP74_02504	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP74_02505	COG0137	argininosuccinate synthase activity
HEP74_02506	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEP74_02509	COG2166	iron-sulfur cluster assembly
HEP74_02522	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP74_02527	COG4303	Ethanolamine ammonia lyase large subunit
HEP74_02528	COG4302	ethanolamine ammonia-lyase activity
HEP74_02529	COG4677	pectinesterase activity
HEP74_02533	COG0402	S-adenosylhomocysteine deaminase activity
HEP74_02534	COG3548	integral membrane protein
HEP74_02536	COG1509	lysine 2,3-aminomutase activity
HEP74_02544	COG1862	Preprotein translocase
HEP74_02547	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEP74_02549	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP74_02551	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEP74_02555	COG3291	Pkd domain containing protein
HEP74_02556	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP74_02558	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEP74_02561	COG0742	ribosomal rna small subunit methyltransferase
HEP74_02563	COG3209	COG3209 Rhs family protein
HEP74_02567	COG3345	alpha-galactosidase
HEP74_02569	COG4771	TonB-dependent receptor
HEP74_02571	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP74_02578	COG0531	amino acid
HEP74_02581	COG0006	proline dipeptidase activity
HEP74_02583	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP74_02586	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP74_02587	COG3938	Belongs to the proline racemase family
HEP74_02589	COG0552	protein localization to endoplasmic reticulum
HEP74_02590	COG1194	a g-specific adenine glycosylase
HEP74_02593	COG2304	oxidoreductase activity
HEP74_02600	COG0835	chemotaxis
HEP74_02601	COG0840	transmembrane signaling receptor activity
HEP74_02602	COG1201	RNA secondary structure unwinding
HEP74_02604	COG3300	MHYT domain
HEP74_02604	COG5001	Diguanylate cyclase
HEP74_02605	COG1185	polyribonucleotide nucleotidyltransferase activity
HEP74_02607	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HEP74_02610	COG0195	Participates in both transcription termination and antitermination
HEP74_02613	COG1007	ATP synthesis coupled electron transport
HEP74_02620	COG1034	ATP synthesis coupled electron transport
HEP74_02621	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEP74_02622	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HEP74_02623	COG0649	NAD binding
HEP74_02624	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP74_02626	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP74_02629	COG0149	triose-phosphate isomerase activity
HEP74_02630	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_02633	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HEP74_02643	COG0101	tRNA pseudouridine synthase activity
HEP74_02645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEP74_02648	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP74_02650	COG0688	phosphatidylethanolamine metabolic process
HEP74_02651	COG0741	lytic transglycosylase activity
HEP74_02652	COG0433	COG0433 Predicted ATPase
HEP74_02653	COG0494	nUDIX hydrolase
HEP74_02656	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP74_02657	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEP74_02662	COG0717	Belongs to the dCTP deaminase family
HEP74_02663	COG0489	protein tyrosine kinase activity
HEP74_02664	COG4771	TonB-dependent receptor
HEP74_02665	COG0457	Tetratricopeptide repeat
HEP74_02667	COG3590	peptidase
HEP74_02669	COG0705	Rhomboid family
HEP74_02674	COG2311	Membrane
HEP74_02675	COG1047	Peptidyl-prolyl cis-trans
HEP74_02676	COG0791	NLP P60 protein
HEP74_02677	COG0791	NLP P60 protein
HEP74_02678	COG1607	acyl-coa hydrolase
HEP74_02679	COG4106	trans-aconitate 2-methyltransferase activity
HEP74_02680	COG1301	dicarboxylic acid transport
HEP74_02681	COG1785	Belongs to the alkaline phosphatase family
HEP74_02683	COG0037	tRNA processing
HEP74_02684	COG1722	exodeoxyribonuclease VII activity
HEP74_02685	COG0142	geranyltranstransferase activity
HEP74_02687	COG4104	PAAR repeat-containing protein
HEP74_02694	COG0312	modulator of DNA gyrase
HEP74_02696	COG0312	modulator of DNA gyrase
HEP74_02700	COG2968	Membrane
HEP74_02703	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HEP74_02706	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEP74_02709	COG0495	leucyl-tRNA aminoacylation
HEP74_02711	COG3118	belongs to the thioredoxin family
HEP74_02715	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HEP74_02717	COG2040	homocysteine
HEP74_02719	COG0346	lactoylglutathione lyase activity
HEP74_02720	COG1131	(ABC) transporter
HEP74_02723	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP74_02723	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP74_02725	COG2878	Part of a membrane complex involved in electron transport
HEP74_02728	COG1595	DNA-templated transcription, initiation
HEP74_02733	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP74_02737	COG0251	oxidation-reduction process
HEP74_02739	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP74_02739	COG0392	lysyltransferase activity
HEP74_02746	COG2814	Major facilitator Superfamily
HEP74_02747	COG1902	pentaerythritol trinitrate reductase activity
HEP74_02749	COG0583	DNA-binding transcription factor activity
HEP74_02752	COG2824	Alkylphosphonate utilization operon protein PhnA
HEP74_02754	COG1047	Peptidyl-prolyl cis-trans
HEP74_02755	COG1077	Cell shape determining protein MreB Mrl
HEP74_02762	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HEP74_02764	COG1451	nucleotide metabolic process
HEP74_02768	COG2205	protein histidine kinase activity
HEP74_02770	COG2186	Transcriptional regulator
HEP74_02771	COG3250	beta-galactosidase activity
HEP74_02783	COG1703	isobutyryl-CoA mutase activity
HEP74_02783	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP74_02783	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP74_02790	COG0443	Heat shock 70 kDa protein
HEP74_02796	COG1960	acyl-CoA dehydrogenase activity
HEP74_02797	COG1793	dna ligase
HEP74_02797	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEP74_02798	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEP74_02798	COG1793	dna ligase
HEP74_02799	COG1201	RNA secondary structure unwinding
HEP74_02801	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP74_02802	COG1278	Cold shock
HEP74_02803	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEP74_02804	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HEP74_02805	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP74_02807	COG2954	triphosphatase activity
HEP74_02810	COG1381	Involved in DNA repair and RecF pathway recombination
HEP74_02811	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEP74_02814	COG0681	Belongs to the peptidase S26 family
HEP74_02815	COG0481	GTPase activity
HEP74_02816	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP74_02819	COG1024	Enoyl-CoA hydratase
HEP74_02819	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP74_02821	COG2855	membrane
HEP74_02824	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HEP74_02825	COG3250	beta-galactosidase activity
HEP74_02826	COG3540	Alkaline phosphatase
HEP74_02831	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HEP74_02835	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HEP74_02837	COG0534	Mate efflux family protein
HEP74_02838	COG0335	large ribosomal subunit rRNA binding
HEP74_02840	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HEP74_02841	COG0228	four-way junction DNA binding
HEP74_02843	COG2070	2-Nitropropane dioxygenase
HEP74_02844	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HEP74_02849	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP74_02854	COG0475	glutathione-regulated potassium exporter activity
HEP74_02858	COG0625	glutathione transferase activity
HEP74_02859	COG1082	Xylose isomerase domain protein TIM barrel
HEP74_02861	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP74_02862	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP74_02863	COG1129	ABC transporter
HEP74_02864	COG1879	ABC-type sugar transport system periplasmic component
HEP74_02865	COG1012	belongs to the aldehyde dehydrogenase family
HEP74_02868	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_02869	COG0129	dihydroxy-acid dehydratase activity
HEP74_02876	COG3152	Membrane
HEP74_02880	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HEP74_02881	COG1845	cytochrome c oxidase, subunit III
HEP74_02882	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP74_02884	COG2964	Protein conserved in bacteria
HEP74_02887	COG4771	TonB-dependent receptor
HEP74_02892	COG0251	oxidation-reduction process
HEP74_02897	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HEP74_02900	COG0196	riboflavin kinase activity
HEP74_02901	COG0728	peptidoglycan biosynthetic process
HEP74_02903	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEP74_02904	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HEP74_02905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HEP74_02906	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP74_02907	COG0824	Thioesterase
HEP74_02909	COG1024	Enoyl-CoA hydratase
HEP74_02909	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP74_02910	COG1946	Acyl-CoA thioesterase
HEP74_02913	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HEP74_02916	COG0840	transmembrane signaling receptor activity
HEP74_02920	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HEP74_02924	COG1073	alpha beta
HEP74_02930	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HEP74_02934	COG4585	Histidine kinase
HEP74_02936	COG0850	regulation of cytokinetic process
HEP74_02937	COG2894	cell division
HEP74_02938	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HEP74_02940	COG2205	protein histidine kinase activity
HEP74_02941	COG0745	RESPONSE REGULATOR receiver
HEP74_02943	COG2194	sulfuric ester hydrolase activity
HEP74_02948	COG2814	Major facilitator Superfamily
HEP74_02949	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP74_02949	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP74_02951	COG4251	negative regulation of phosphorylation
HEP74_02951	COG2203	Gaf domain
HEP74_02951	COG3706	GGDEF domain
HEP74_02951	COG5001	Diguanylate cyclase
HEP74_02952	COG0753	catalase activity
HEP74_02957	COG1063	alcohol dehydrogenase
HEP74_02959	COG3459	Glycosyltransferase 36 associated
HEP74_02960	COG2186	Transcriptional regulator
HEP74_02964	COG2271	Major facilitator Superfamily
HEP74_02965	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_02973	COG1064	alcohol dehydrogenase
HEP74_02977	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_02980	COG0492	ferredoxin-NADP+ reductase activity
HEP74_02986	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_02987	COG3387	PFAM Glycoside hydrolase 15-related
HEP74_02989	COG3275	phosphorelay sensor kinase activity
HEP74_02998	COG0732	type I restriction modification DNA specificity domain
HEP74_03007	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEP74_03009	COG0330	HflC and HflK could
HEP74_03010	COG0330	HflC and HflK could
HEP74_03011	COG0604	alcohol dehydrogenase
HEP74_03015	COG0678	peroxiredoxin activity
HEP74_03019	COG4953	penicillin-binding protein 1C
HEP74_03020	COG1349	DNA-binding transcription factor activity
HEP74_03022	COG2223	nitrite transmembrane transporter activity
HEP74_03028	COG0577	efflux transmembrane transporter activity
HEP74_03028	COG1136	(ABC) transporter
HEP74_03032	COG2373	Large extracellular alpha-helical protein
HEP74_03042	COG0372	Belongs to the citrate synthase family
HEP74_03044	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP74_03047	COG0587	DNA-directed DNA polymerase activity
HEP74_03053	COG2161	toxin-antitoxin pair type II binding
HEP74_03054	COG4115	mRNA cleavage
HEP74_03058	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEP74_03059	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEP74_03060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEP74_03062	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP74_03063	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_03064	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HEP74_03065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP74_03067	COG1399	metal-binding, possibly nucleic acid-binding protein
HEP74_03072	COG0714	Associated with various cellular activities
HEP74_03076	COG0537	adenosine 5'-monophosphoramidase activity
HEP74_03081	COG0314	molybdopterin synthase activity
HEP74_03082	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HEP74_03083	COG0315	cyclic pyranopterin monophosphate synthase activity
HEP74_03085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEP74_03086	COG1234	tRNA 3'-trailer cleavage
HEP74_03088	COG0859	PFAM glycosyl transferase family 9
HEP74_03091	COG0631	protein serine/threonine phosphatase activity
HEP74_03092	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP74_03095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP74_03096	COG1388	LysM domain
HEP74_03096	COG3942	CHAP domain
HEP74_03103	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEP74_03105	COG0544	peptidyl-prolyl cis-trans isomerase activity
HEP74_03114	COG0473	3-isopropylmalate dehydrogenase activity
HEP74_03117	COG4783	chaperone-mediated protein folding
HEP74_03120	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HEP74_03121	COG0248	Ppx GppA phosphatase
HEP74_03122	COG0438	transferase activity, transferring glycosyl groups
HEP74_03124	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEP74_03126	COG3291	Pkd domain containing protein
HEP74_03127	COG2833	Protein of unknown function (DUF455)
HEP74_03131	COG0285	dihydrofolate synthase activity
HEP74_03132	COG0588	phosphoglycerate mutase activity
HEP74_03136	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HEP74_03137	COG4208	sulfate ABC transporter
HEP74_03138	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HEP74_03139	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HEP74_03144	COG2885	chlorophyll binding
HEP74_03145	COG0583	DNA-binding transcription factor activity
HEP74_03146	COG2814	Major facilitator Superfamily
HEP74_03148	COG0667	Aldo Keto reductase
HEP74_03150	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP74_03150	COG1902	pentaerythritol trinitrate reductase activity
HEP74_03158	COG0625	glutathione transferase activity
HEP74_03164	COG0039	L-malate dehydrogenase activity
HEP74_03166	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEP74_03167	COG1217	gtp-binding protein TYPA
HEP74_03169	COG0154	amidase activity
HEP74_03171	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HEP74_03173	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HEP74_03174	COG0203	ribosomal protein L17
HEP74_03176	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEP74_03179	COG0201	protein transport
HEP74_03181	COG1841	ribosomal large subunit assembly
HEP74_03187	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEP74_03188	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEP74_03190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEP74_03191	COG0255	Belongs to the universal ribosomal protein uL29 family
HEP74_03196	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEP74_03197	COG0089	rRNA binding
HEP74_03198	COG0088	Forms part of the polypeptide exit tunnel
HEP74_03200	COG0051	transcription antitermination factor activity, RNA binding
HEP74_03201	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP74_03202	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP74_03205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEP74_03207	COG0222	ribosome binding
HEP74_03210	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEP74_03211	COG0250	Participates in transcription elongation, termination and antitermination
HEP74_03214	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP74_03218	COG0012	GTP binding
HEP74_03219	COG0193	aminoacyl-tRNA hydrolase activity
HEP74_03221	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEP74_03223	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HEP74_03226	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HEP74_03227	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEP74_03230	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEP74_03234	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP74_03235	COG1295	ribonuclease BN
HEP74_03239	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEP74_03240	COG1404	Belongs to the peptidase S8 family
HEP74_03241	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEP74_03242	COG2151	metal-sulfur cluster biosynthetic enzyme
HEP74_03253	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP74_03253	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP74_03259	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP74_03261	COG3634	alkyl hydroperoxide reductase activity
HEP74_03262	COG0583	DNA-binding transcription factor activity
HEP74_03264	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP74_03265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP74_03269	COG2197	response regulator
HEP74_03274	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP74_03277	COG0697	spore germination
HEP74_03286	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP74_03287	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP74_03289	COG2096	Adenosyltransferase
HEP74_03292	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HEP74_03293	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HEP74_03295	COG2967	ApaG domain
HEP74_03296	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HEP74_03302	COG1704	LemA family
HEP74_03303	COG0861	Integral membrane protein TerC family
HEP74_03304	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HEP74_03307	COG2205	protein histidine kinase activity
HEP74_03311	COG0642	Histidine kinase
HEP74_03314	COG4181	ATPase activity
HEP74_03315	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HEP74_03319	COG4771	TonB-dependent receptor
HEP74_03321	COG0667	Aldo Keto reductase
HEP74_03322	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HEP74_03326	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEP74_03336	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP74_03337	COG4305	rare lipoprotein A
HEP74_03340	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_03341	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEP74_03343	COG4191	Histidine kinase
HEP74_03344	COG0784	Response regulator, receiver
HEP74_03345	COG2205	protein histidine kinase activity
HEP74_03345	COG2202	Pas domain
HEP74_03347	COG2823	Periplasmic or secreted lipoprotein
HEP74_03348	COG0673	inositol 2-dehydrogenase activity
HEP74_03349	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP74_03351	COG1090	epimerase
HEP74_03357	COG1051	belongs to the nudix hydrolase family
HEP74_03357	COG1056	cytidyltransferase-related domain
HEP74_03363	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEP74_03364	COG0321	lipoyl(octanoyl) transferase activity
HEP74_03367	COG1686	Belongs to the peptidase S11 family
HEP74_03369	COG2951	lytic endotransglycosylase activity
HEP74_03370	COG1012	belongs to the aldehyde dehydrogenase family
HEP74_03373	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HEP74_03375	COG0772	Belongs to the SEDS family
HEP74_03376	COG0768	penicillin binding
HEP74_03378	COG1792	Involved in formation and maintenance of cell shape
HEP74_03379	COG1077	Cell shape determining protein MreB Mrl
HEP74_03380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP74_03381	COG3284	Transcriptional regulator
HEP74_03383	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HEP74_03385	COG2010	Cytochrome c
HEP74_03390	COG0596	Alpha beta hydrolase
HEP74_03390	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP74_03391	COG0308	aminopeptidase N
HEP74_03392	COG2226	methyltransferase
HEP74_03399	COG0494	nUDIX hydrolase
HEP74_03402	COG0739	heme binding
HEP74_03404	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HEP74_03405	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEP74_03407	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HEP74_03408	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP74_03410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP74_03413	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HEP74_03416	COG3116	cell division
HEP74_03417	COG0275	rRNA processing
HEP74_03418	COG2001	Belongs to the MraZ family
HEP74_03425	COG1988	membrane-bound metal-dependent
HEP74_03426	COG0277	FAD linked oxidase domain protein
HEP74_03429	COG0745	RESPONSE REGULATOR receiver
HEP74_03430	COG2205	protein histidine kinase activity
HEP74_03431	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HEP74_03432	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP74_03433	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEP74_03437	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HEP74_03438	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP74_03439	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HEP74_03442	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP74_03442	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP74_03444	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HEP74_03448	COG0477	Major facilitator Superfamily
HEP74_03449	COG0488	(ABC) transporter
HEP74_03450	COG0242	peptide deformylase activity
HEP74_03452	COG1960	acyl-CoA dehydrogenase activity
HEP74_03454	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP74_03456	COG1696	Membrane protein involved in D-alanine export
HEP74_03460	COG1215	transferase activity, transferring glycosyl groups
HEP74_03462	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HEP74_03463	COG0457	Tetratricopeptide repeat
HEP74_03464	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HEP74_03465	COG1215	transferase activity, transferring glycosyl groups
HEP74_03466	COG1215	transferase activity, transferring glycosyl groups
HEP74_03478	COG2188	Transcriptional regulator
HEP74_03481	COG1450	Type ii and iii secretion system protein
HEP74_03484	COG3166	PFAM Fimbrial assembly family protein
HEP74_03485	COG3156	type II secretion system protein K
HEP74_03486	COG4795	General secretion pathway protein
HEP74_03487	COG2165	general secretion pathway protein
HEP74_03488	COG4970	Tfp pilus assembly protein FimT
HEP74_03489	COG2165	general secretion pathway protein
HEP74_03491	COG1459	type II secretion system
HEP74_03492	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEP74_03493	COG1404	Belongs to the peptidase S8 family
HEP74_03494	COG5295	Hep Hag repeat protein
HEP74_03495	COG0047	phosphoribosylformylglycinamidine synthase activity
HEP74_03495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEP74_03496	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP74_03497	COG4974	Belongs to the 'phage' integrase family
HEP74_03502	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP74_03508	COG1183	phosphatidylcholine synthase activity
HEP74_03510	COG0442	prolyl-tRNA aminoacylation
HEP74_03513	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEP74_03514	COG1127	ABC transporter
HEP74_03515	COG3218	ABC-type transport auxiliary lipoprotein component
HEP74_03515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEP74_03522	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP74_03523	COG0662	Cupin 2, conserved barrel domain protein
HEP74_03523	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HEP74_03529	COG2086	electron transfer activity
HEP74_03532	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEP74_03532	COG0546	phosphoglycolate phosphatase activity
HEP74_03533	COG0277	FAD linked oxidase domain protein
HEP74_03534	COG0300	oxidoreductase activity
HEP74_03535	COG2226	methyltransferase
HEP74_03536	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP74_03543	COG2226	methyltransferase
HEP74_03545	COG3754	Rhamnan synthesis protein F
HEP74_03546	COG0438	transferase activity, transferring glycosyl groups
HEP74_03546	COG1216	Glycosyl transferase, family 2
HEP74_03550	COG0626	cystathionine gamma-synthase activity
HEP74_03556	COG0625	glutathione transferase activity
HEP74_03558	COG0513	Belongs to the DEAD box helicase family
HEP74_03559	COG0720	synthase
HEP74_03561	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEP74_03562	COG1956	GAF domain-containing protein
HEP74_03564	COG4206	TonB-dependent receptor
HEP74_03565	COG0546	phosphoglycolate phosphatase activity
HEP74_03569	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEP74_03574	COG0339	signal peptide processing
HEP74_03575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEP74_03577	COG2217	Heavy metal translocating P-type atpase
HEP74_03580	COG2132	Multicopper oxidase
HEP74_03585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP74_03587	COG1136	(ABC) transporter
HEP74_03588	COG0577	efflux transmembrane transporter activity
HEP74_03589	COG1136	(ABC) transporter
HEP74_03589	COG0577	efflux transmembrane transporter activity
HEP74_03590	COG0577	efflux transmembrane transporter activity
HEP74_03591	COG0577	efflux transmembrane transporter activity
HEP74_03593	COG0577	efflux transmembrane transporter activity
HEP74_03593	COG1136	(ABC) transporter
HEP74_03595	COG0577	efflux transmembrane transporter activity
HEP74_03595	COG1136	(ABC) transporter
HEP74_03598	COG4191	Histidine kinase
HEP74_03600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEP74_03603	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HEP74_03606	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEP74_03608	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEP74_03610	COG0356	it plays a direct role in the translocation of protons across the membrane
HEP74_03614	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP74_03615	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP74_03622	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEP74_03623	COG0697	spore germination
HEP74_03624	COG1666	GTP binding
HEP74_03626	COG1187	pseudouridine synthase activity
HEP74_03631	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP74_03631	COG2205	protein histidine kinase activity
HEP74_03636	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP74_03649	COG0842	Transport permease protein
HEP74_03650	COG1131	(ABC) transporter
HEP74_03651	COG0025	NhaP-type Na H and K H
HEP74_03653	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HEP74_03654	COG1573	uracil-dna glycosylase
HEP74_03656	COG3384	dioxygenase
HEP74_03660	COG0667	Aldo Keto reductase
HEP74_03661	COG0667	Aldo Keto reductase
HEP74_03664	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP74_03665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP74_03671	COG5001	Diguanylate cyclase
HEP74_03678	COG3275	phosphorelay sensor kinase activity
HEP74_03683	COG0531	amino acid
HEP74_03687	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP74_03687	COG5297	Belongs to the glycosyl hydrolase family 6
HEP74_03688	COG0612	Peptidase, M16
HEP74_03693	COG0741	lytic transglycosylase activity
HEP74_03698	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HEP74_03699	COG2207	Transcriptional regulator
HEP74_03702	COG0598	Magnesium transport protein CorA
HEP74_03703	COG1113	amino acid transport
HEP74_03705	COG0697	spore germination
HEP74_03712	COG2409	Drug exporters of the RND superfamily
HEP74_03713	COG4178	(ABC) transporter
HEP74_03715	COG5520	Belongs to the glycosyl hydrolase 30 family
HEP74_03746	COG0584	glycerophosphoryl diester phosphodiesterase
HEP74_03749	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HEP74_03753	COG2827	Endonuclease containing a URI domain
HEP74_03755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEP74_03760	COG1595	DNA-templated transcription, initiation
HEP74_03761	COG0459	protein refolding
HEP74_03763	COG2356	endonuclease I
HEP74_03764	COG1324	tolerance protein
HEP74_03766	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP74_03769	COG1733	regulation of RNA biosynthetic process
HEP74_03770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HEP74_03771	COG0511	ligase activity, forming carbon-carbon bonds
HEP74_03773	COG0439	Biotin carboxylase
HEP74_03775	COG0300	oxidoreductase activity
HEP74_03778	COG2264	protein methyltransferase activity
HEP74_03782	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HEP74_03783	COG4589	Belongs to the CDS family
HEP74_03788	COG0671	phosphoesterase, PA-phosphatase related
HEP74_03788	COG2453	phosphatase
HEP74_03789	COG2267	carboxylic ester hydrolase activity
HEP74_03790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP74_03791	COG0138	bifunctional purine biosynthesis protein purh
HEP74_03793	COG0151	Belongs to the GarS family
HEP74_03795	COG1289	transmembrane transporter activity
HEP74_03796	COG2814	Major facilitator Superfamily
HEP74_03819	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HEP74_03822	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HEP74_03823	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP74_03824	COG0730	response to heat
HEP74_03826	COG0134	indole-3-glycerol-phosphate synthase activity
HEP74_03828	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEP74_03834	COG1597	lipid kinase activity
HEP74_03837	COG0484	heat shock protein binding
HEP74_03839	COG2814	Major facilitator Superfamily
HEP74_03840	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
HEP74_03844	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP74_03845	COG2111	Na H antiporter
HEP74_03845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEP74_03846	COG1006	Multisubunit Na H antiporter MnhC subunit
HEP74_03847	COG0651	ATP synthesis coupled electron transport
HEP74_03849	COG2212	antiporter activity
HEP74_03850	COG1320	monovalent cation:proton antiporter activity
HEP74_03855	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HEP74_03859	COG3104	oligopeptide transport
HEP74_03863	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HEP74_03868	COG3227	Zinc metalloprotease (Elastase)
HEP74_03869	COG0513	Belongs to the DEAD box helicase family
HEP74_03871	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_03873	COG0702	epimerase
HEP74_03874	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP74_03876	COG2354	Protein conserved in bacteria
HEP74_03879	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP74_03881	COG1196	nuclear chromosome segregation
HEP74_03881	COG3264	Mechanosensitive ion channel
HEP74_03882	COG0604	alcohol dehydrogenase
HEP74_03882	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_03882	COG3321	synthase
HEP74_03886	COG1595	DNA-templated transcription, initiation
HEP74_03890	COG1802	Transcriptional regulator
HEP74_03897	COG3052	prosthetic group binding
HEP74_03900	COG1414	Transcriptional regulator
HEP74_03901	COG0738	Major facilitator superfamily
HEP74_03902	COG3254	rhamnose metabolic process
HEP74_03904	COG4948	Mandelate Racemase Muconate Lactonizing
HEP74_03905	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP74_03906	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_03914	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP74_03917	COG4807	Protein conserved in bacteria
HEP74_03923	COG0708	Exodeoxyribonuclease III
HEP74_03928	COG5507	3-demethylubiquinone-9 3-methyltransferase
HEP74_03929	COG4773	Receptor
HEP74_03932	COG3220	belongs to the UPF0276 family
HEP74_03950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP74_03955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP74_03956	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP74_03959	COG0753	catalase activity
HEP74_03963	COG4773	Receptor
HEP74_03964	COG2197	response regulator
HEP74_03965	COG4585	Histidine kinase
HEP74_03968	COG1131	(ABC) transporter
HEP74_03969	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEP74_03970	COG1136	(ABC) transporter
HEP74_03971	COG0577	efflux transmembrane transporter activity
HEP74_03974	COG2962	Rard protein
HEP74_03975	COG0697	spore germination
HEP74_03978	COG0180	Tryptophanyl-tRNA synthetase
HEP74_03980	COG3237	CsbD-like
HEP74_03987	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HEP74_03987	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HEP74_03989	COG3228	Belongs to the MtfA family
HEP74_03996	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEP74_04003	COG1222	aaa ATPase
HEP74_04022	COG2084	Dehydrogenase
HEP74_04023	COG1902	pentaerythritol trinitrate reductase activity
HEP74_04030	COG1404	Belongs to the peptidase S8 family
HEP74_04031	COG2814	Major facilitator Superfamily
HEP74_04032	COG0583	DNA-binding transcription factor activity
HEP74_04036	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP74_04037	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP74_04043	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HEP74_04044	COG1764	response to oxidative stress
HEP74_04045	COG1846	Transcriptional regulator
HEP74_04047	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HEP74_04049	COG0697	spore germination
HEP74_04050	COG0523	cobalamin synthesis protein
HEP74_04053	COG3245	cytochrome
HEP74_04055	COG1960	acyl-CoA dehydrogenase activity
HEP74_04056	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP74_04069	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEP74_04070	COG3387	PFAM Glycoside hydrolase 15-related
HEP74_04071	COG0745	RESPONSE REGULATOR receiver
HEP74_04074	COG1404	Belongs to the peptidase S8 family
HEP74_04076	COG3100	YcgL domain-containing protein
HEP74_04077	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP74_04079	COG0463	Glycosyl transferase, family 2
HEP74_04081	COG1028	Short-chain dehydrogenase reductase Sdr
HEP74_04087	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HEP74_04090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP74_04095	COG1294	oxidase, subunit
HEP74_04096	COG1271	oxidase subunit
HEP74_04100	COG0408	coproporphyrinogen oxidase activity
HEP74_04102	COG2323	membrane
HEP74_04112	COG0515	serine threonine protein kinase
HEP74_04113	COG0631	protein serine/threonine phosphatase activity
HEP74_04136	COG0589	response to stress
HEP74_04139	COG3568	Endonuclease Exonuclease Phosphatase
HEP74_04141	COG0392	lysyltransferase activity
HEP74_04144	COG3275	phosphorelay sensor kinase activity
HEP74_04145	COG3279	Response regulator of the LytR AlgR family
HEP74_04147	COG0210	DNA helicase
HEP74_04163	COG0463	Glycosyl transferase, family 2
HEP74_04165	COG1475	DNA binding
HEP74_04166	COG1192	Involved in chromosome partitioning
HEP74_04167	COG0357	Ribosomal RNA small subunit methyltransferase G
HEP74_04169	COG2091	lysine biosynthetic process via aminoadipic acid
HEP74_04174	COG1011	Hydrolase
HEP74_04175	COG0477	Major facilitator Superfamily
HEP74_04179	COG1971	Probably functions as a manganese efflux pump
HEP74_04182	COG0457	Tetratricopeptide repeat
HEP74_04183	COG2205	protein histidine kinase activity
HEP74_04185	COG5001	Diguanylate cyclase
HEP74_04186	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP74_04187	COG3459	Glycosyltransferase 36 associated
HEP74_04188	COG2211	Major facilitator Superfamily
HEP74_04189	COG3265	gluconokinase activity
HEP74_04190	COG2094	Belongs to the DNA glycosylase MPG family
HEP74_04193	COG2911	Protein conserved in bacteria
HEP74_04194	COG0729	surface antigen
HEP74_04198	COG3132	Protein of unknown function, DUF480
HEP74_04202	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HEP74_04203	COG0284	orotidine-5'-phosphate decarboxylase activity
HEP74_04206	COG1609	Transcriptional regulator
HEP74_04209	COG2937	Belongs to the GPAT DAPAT family
HEP74_04213	COG2211	Major facilitator Superfamily
HEP74_04216	COG3693	PFAM glycoside hydrolase, family 10
HEP74_04218	COG3250	beta-galactosidase activity
HEP74_04222	COG3386	PFAM SMP-30 Gluconolaconase
HEP74_04224	COG0667	Aldo Keto reductase
HEP74_04225	COG0583	DNA-binding transcription factor activity
HEP74_04231	COG0251	oxidation-reduction process
HEP74_04237	COG0246	Mannitol dehydrogenase
HEP74_04238	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP74_04240	COG4948	Mandelate Racemase Muconate Lactonizing
HEP74_04242	COG3661	Belongs to the glycosyl hydrolase 67 family
HEP74_04244	COG2115	Belongs to the xylose isomerase family
HEP74_04246	COG0037	tRNA processing
HEP74_04249	COG0840	transmembrane signaling receptor activity
HEP74_04251	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HEP74_04253	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP74_04255	COG0805	protein transport
HEP74_04257	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP74_04257	COG0519	Catalyzes the synthesis of GMP from XMP
HEP74_04262	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEP74_04265	COG0210	DNA helicase
HEP74_04266	COG1435	thymidine kinase activity
HEP74_04268	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HEP74_04271	COG0515	serine threonine protein kinase
HEP74_04271	COG2815	serine threonine protein kinase
HEP74_04273	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP74_04276	COG1119	ATPase activity
HEP74_04279	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HEP74_04281	COG1335	isochorismatase
HEP74_04285	COG1733	regulation of RNA biosynthetic process
HEP74_04289	COG0706	membrane insertase activity
HEP74_04290	COG0594	ribonuclease P activity