locus-tag	class	description
G4Q83_00020	COG1295	ribonuclease BN
G4Q83_00025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4Q83_00045	COG0521	Mo-molybdopterin cofactor biosynthetic process
G4Q83_00070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G4Q83_00075	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G4Q83_00090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G4Q83_00100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G4Q83_00110	COG0193	aminoacyl-tRNA hydrolase activity
G4Q83_00115	COG0012	GTP binding
G4Q83_00125	COG0477	Major facilitator Superfamily
G4Q83_00130	COG0302	gtp cyclohydrolase
G4Q83_00140	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_00195	COG0676	glucose-6-phosphate 1-epimerase activity
G4Q83_00300	COG1858	cytochrome C peroxidase
G4Q83_00310	COG1166	arginine decarboxylase activity
G4Q83_00325	COG2960	long-chain fatty acid transporting porin activity
G4Q83_00330	COG0606	chelatase, subunit chli
G4Q83_00360	COG3039	Transposase
G4Q83_00370	COG4585	Histidine kinase
G4Q83_00400	COG3387	PFAM Glycoside hydrolase 15-related
G4Q83_00420	COG3100	YcgL domain-containing protein
G4Q83_00425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4Q83_00435	COG0463	Glycosyl transferase, family 2
G4Q83_00480	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G4Q83_00485	COG0511	ligase activity, forming carbon-carbon bonds
G4Q83_00490	COG0439	Biotin carboxylase
G4Q83_00505	COG0242	peptide deformylase activity
G4Q83_00510	COG0488	(ABC) transporter
G4Q83_00515	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_00545	COG0745	RESPONSE REGULATOR receiver
G4Q83_00560	COG2954	triphosphatase activity
G4Q83_00575	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Q83_00595	COG4213	ABC transporter substrate-binding protein
G4Q83_00605	COG4214	carbohydrate transport
G4Q83_00625	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Q83_00630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
G4Q83_00635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G4Q83_00655	COG1201	RNA secondary structure unwinding
G4Q83_00660	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G4Q83_00660	COG1793	dna ligase
G4Q83_00665	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G4Q83_00665	COG1793	dna ligase
G4Q83_00670	COG1960	acyl-CoA dehydrogenase activity
G4Q83_00700	COG0183	Belongs to the thiolase family
G4Q83_00735	COG1063	alcohol dehydrogenase
G4Q83_00760	COG0753	catalase activity
G4Q83_00780	COG2814	Major facilitator Superfamily
G4Q83_00805	COG2197	response regulator
G4Q83_00825	COG2194	sulfuric ester hydrolase activity
G4Q83_00835	COG0745	RESPONSE REGULATOR receiver
G4Q83_00840	COG2205	protein histidine kinase activity
G4Q83_00855	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G4Q83_00860	COG2894	cell division
G4Q83_00865	COG0850	regulation of cytokinetic process
G4Q83_00875	COG4585	Histidine kinase
G4Q83_00905	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
G4Q83_00970	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
G4Q83_01035	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G4Q83_01045	COG1946	Acyl-CoA thioesterase
G4Q83_01050	COG1024	Enoyl-CoA hydratase
G4Q83_01050	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4Q83_01065	COG0824	Thioesterase
G4Q83_01070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4Q83_01075	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G4Q83_01080	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G4Q83_01085	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G4Q83_01145	COG0196	riboflavin kinase activity
G4Q83_01160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G4Q83_01185	COG0750	zinc metalloprotease
G4Q83_01200	COG2964	Protein conserved in bacteria
G4Q83_01210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4Q83_01215	COG1845	cytochrome c oxidase, subunit III
G4Q83_01220	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G4Q83_01225	COG1595	DNA-templated transcription, initiation
G4Q83_01230	COG0740	serine-type endopeptidase activity
G4Q83_01320	COG4794	Type iii secretion
G4Q83_01345	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G4Q83_01390	COG2207	Transcriptional regulator
G4Q83_01415	COG0129	dihydroxy-acid dehydratase activity
G4Q83_01420	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_01435	COG3210	domain, Protein
G4Q83_01440	COG2831	hemolysin activation secretion protein
G4Q83_01450	COG0745	RESPONSE REGULATOR receiver
G4Q83_01455	COG4771	TonB-dependent receptor
G4Q83_01460	COG0642	Histidine kinase
G4Q83_01480	COG0714	Associated with various cellular activities
G4Q83_01545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G4Q83_01555	COG0586	Pfam SNARE associated Golgi protein
G4Q83_01565	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_01575	COG0346	lactoylglutathione lyase activity
G4Q83_01580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4Q83_01590	COG4206	TonB-dependent receptor
G4Q83_01600	COG2010	Cytochrome c
G4Q83_01610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G4Q83_01615	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
G4Q83_01625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G4Q83_01640	COG1773	rubredoxin
G4Q83_01645	COG2912	Transglutaminase-like superfamily
G4Q83_01665	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_01690	COG2968	Membrane
G4Q83_01695	COG0424	maF-like protein
G4Q83_01710	COG0312	modulator of DNA gyrase
G4Q83_01715	COG3028	Belongs to the UPF0307 family
G4Q83_01720	COG0312	modulator of DNA gyrase
G4Q83_01730	COG4104	PAAR repeat-containing protein
G4Q83_01735	COG0142	geranyltranstransferase activity
G4Q83_01740	COG1722	exodeoxyribonuclease VII activity
G4Q83_01745	COG0037	tRNA processing
G4Q83_01755	COG1785	Belongs to the alkaline phosphatase family
G4Q83_01760	COG1301	dicarboxylic acid transport
G4Q83_01780	COG1607	acyl-coa hydrolase
G4Q83_01785	COG0791	NLP P60 protein
G4Q83_01790	COG0791	NLP P60 protein
G4Q83_01795	COG1047	Peptidyl-prolyl cis-trans
G4Q83_01800	COG2311	Membrane
G4Q83_01870	COG3590	peptidase
G4Q83_01890	COG4771	TonB-dependent receptor
G4Q83_01895	COG0489	protein tyrosine kinase activity
G4Q83_01900	COG0717	Belongs to the dCTP deaminase family
G4Q83_01915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4Q83_01980	COG0494	nUDIX hydrolase
G4Q83_01985	COG0433	COG0433 Predicted ATPase
G4Q83_01990	COG0741	lytic transglycosylase activity
G4Q83_02000	COG0688	phosphatidylethanolamine metabolic process
G4Q83_02010	COG2890	protein-(glutamine-N5) methyltransferase activity
G4Q83_02025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G4Q83_02040	COG0101	tRNA pseudouridine synthase activity
G4Q83_02095	COG1959	2 iron, 2 sulfur cluster binding
G4Q83_02140	COG0297	glycogen (starch) synthase activity
G4Q83_02155	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_02160	COG0149	triose-phosphate isomerase activity
G4Q83_02175	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Q83_02185	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Q83_02190	COG0649	NAD binding
G4Q83_02195	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
G4Q83_02200	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G4Q83_02205	COG1034	ATP synthesis coupled electron transport
G4Q83_02240	COG1007	ATP synthesis coupled electron transport
G4Q83_02255	COG0195	Participates in both transcription termination and antitermination
G4Q83_02280	COG1185	polyribonucleotide nucleotidyltransferase activity
G4Q83_02300	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G4Q83_02315	COG0840	transmembrane signaling receptor activity
G4Q83_02320	COG0835	chemotaxis
G4Q83_02350	COG2080	2 iron, 2 sulfur cluster binding
G4Q83_02355	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G4Q83_02375	COG3214	Protein conserved in bacteria
G4Q83_02480	COG2226	methyltransferase
G4Q83_02560	COG2373	Large extracellular alpha-helical protein
G4Q83_02600	COG2205	protein histidine kinase activity
G4Q83_02600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4Q83_02625	COG1187	pseudouridine synthase activity
G4Q83_02635	COG1666	GTP binding
G4Q83_02640	COG0697	spore germination
G4Q83_02650	COG2011	ABC-type metal ion transport system permease component
G4Q83_02685	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4Q83_02690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4Q83_02710	COG0356	it plays a direct role in the translocation of protons across the membrane
G4Q83_02720	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G4Q83_02725	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4Q83_02730	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G4Q83_02740	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G4Q83_02745	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G4Q83_02765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G4Q83_02780	COG4191	Histidine kinase
G4Q83_02790	COG0577	efflux transmembrane transporter activity
G4Q83_02790	COG1136	(ABC) transporter
G4Q83_02800	COG0577	efflux transmembrane transporter activity
G4Q83_02800	COG1136	(ABC) transporter
G4Q83_02810	COG1136	(ABC) transporter
G4Q83_02810	COG0577	efflux transmembrane transporter activity
G4Q83_02815	COG0577	efflux transmembrane transporter activity
G4Q83_02820	COG0577	efflux transmembrane transporter activity
G4Q83_02830	COG1136	(ABC) transporter
G4Q83_02840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4Q83_02865	COG2132	Multicopper oxidase
G4Q83_02890	COG2217	Heavy metal translocating P-type atpase
G4Q83_02905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4Q83_02915	COG4178	(ABC) transporter
G4Q83_02920	COG3118	belongs to the thioredoxin family
G4Q83_02930	COG0339	signal peptide processing
G4Q83_02950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G4Q83_02955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4Q83_02970	COG0583	DNA-binding transcription factor activity
G4Q83_02975	COG0546	phosphoglycolate phosphatase activity
G4Q83_02980	COG4206	TonB-dependent receptor
G4Q83_02990	COG1956	GAF domain-containing protein
G4Q83_02995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G4Q83_03005	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_03015	COG0583	DNA-binding transcription factor activity
G4Q83_03050	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_03065	COG1902	pentaerythritol trinitrate reductase activity
G4Q83_03075	COG1162	GTPase activity
G4Q83_03100	COG2211	Major facilitator Superfamily
G4Q83_03105	COG1609	Transcriptional regulator
G4Q83_03110	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_03115	COG2851	Citrate transporter
G4Q83_03130	COG0642	Histidine kinase
G4Q83_03145	COG2197	response regulator
G4Q83_03160	COG2963	transposase activity
G4Q83_03190	COG4191	Histidine kinase
G4Q83_03200	COG1301	dicarboxylic acid transport
G4Q83_03270	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_03295	COG1560	Kdo2-lipid A biosynthetic process
G4Q83_03300	COG1519	Transferase
G4Q83_03305	COG1538	Outer membrane efflux protein
G4Q83_03310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G4Q83_03320	COG2201	protein-glutamate methylesterase activity
G4Q83_03335	COG3537	Alpha-1,2-mannosidase
G4Q83_03345	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Q83_03355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
G4Q83_03360	COG3858	chitin binding
G4Q83_03360	COG1388	LysM domain
G4Q83_03385	COG0837	glucose binding
G4Q83_03400	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G4Q83_03410	COG0494	nUDIX hydrolase
G4Q83_03415	COG1218	3'(2'),5'-bisphosphate nucleotidase
G4Q83_03420	COG3956	TIGRFAM MazG family protein
G4Q83_03425	COG0330	HflC and HflK could
G4Q83_03490	COG2124	cytochrome p450
G4Q83_03495	COG2124	cytochrome p450
G4Q83_03500	COG1141	Ferredoxin
G4Q83_03505	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_03510	COG2124	cytochrome p450
G4Q83_03515	COG0142	geranyltranstransferase activity
G4Q83_03525	COG1657	PFAM Prenyltransferase squalene oxidase
G4Q83_03535	COG1304	FMN binding
G4Q83_03550	COG1309	transcriptional regulator
G4Q83_03555	COG4206	TonB-dependent receptor
G4Q83_03565	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G4Q83_03570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4Q83_03575	COG0463	Glycosyl transferase, family 2
G4Q83_03580	COG0517	IMP dehydrogenase activity
G4Q83_03590	COG1272	protein, Hemolysin III
G4Q83_03595	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G4Q83_03605	COG1131	(ABC) transporter
G4Q83_03610	COG1725	Transcriptional regulator
G4Q83_03615	COG0739	heme binding
G4Q83_03620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G4Q83_03625	COG0626	cystathionine gamma-synthase activity
G4Q83_03630	COG0460	homoserine dehydrogenase
G4Q83_03630	COG0527	aspartate kinase activity
G4Q83_03640	COG3706	GGDEF domain
G4Q83_03645	COG1760	l-serine dehydratase
G4Q83_03660	COG3038	cytochrome b561
G4Q83_03685	COG0477	Major facilitator Superfamily
G4Q83_03695	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G4Q83_03705	COG4977	sequence-specific DNA binding
G4Q83_03710	COG1335	isochorismatase
G4Q83_03745	COG1842	Phage shock protein A
G4Q83_03770	COG5463	Belongs to the UPF0441 family
G4Q83_03775	COG0754	glutathionylspermidine amidase activity
G4Q83_03780	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_03790	COG4804	nuclease activity
G4Q83_03805	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_03845	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G4Q83_03870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G4Q83_03885	COG0495	leucyl-tRNA aminoacylation
G4Q83_03895	COG3118	belongs to the thioredoxin family
G4Q83_03910	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G4Q83_03920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G4Q83_03950	COG3079	Belongs to the UPF0149 family
G4Q83_03955	COG0006	proline dipeptidase activity
G4Q83_03960	COG0006	proline dipeptidase activity
G4Q83_04025	COG2814	Major facilitator Superfamily
G4Q83_04040	COG0640	Transcriptional regulator
G4Q83_04080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4Q83_04090	COG1216	Glycosyl transferase, family 2
G4Q83_04095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4Q83_04105	COG1199	ATP-dependent helicase activity
G4Q83_04120	COG0189	ligase activity
G4Q83_04135	COG0835	chemotaxis
G4Q83_04140	COG0840	transmembrane signaling receptor activity
G4Q83_04145	COG0784	Response regulator, receiver
G4Q83_04145	COG0643	Histidine kinase
G4Q83_04145	COG2198	Histidine kinase
G4Q83_04145	COG2198	Histidine kinase
G4Q83_04145	COG0784	Response regulator, receiver
G4Q83_04145	COG0643	Histidine kinase
G4Q83_04150	COG2201	protein-glutamate methylesterase activity
G4Q83_04195	COG0583	DNA-binding transcription factor activity
G4Q83_04200	COG0483	inositol monophosphate 1-phosphatase activity
G4Q83_04210	COG0300	oxidoreductase activity
G4Q83_04230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G4Q83_04240	COG1256	bacterial-type flagellum assembly
G4Q83_04240	COG4786	Flagellar basal body rod
G4Q83_04240	COG1256	bacterial-type flagellum assembly
G4Q83_04240	COG4786	Flagellar basal body rod
G4Q83_04255	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G4Q83_04270	COG1749	Flagellar hook protein flgE
G4Q83_04280	COG1558	bacterial-type flagellum-dependent cell motility
G4Q83_04290	COG0835	chemotaxis
G4Q83_04290	COG0784	Response regulator, receiver
G4Q83_04335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4Q83_04340	COG1116	anion transmembrane transporter activity
G4Q83_04370	COG1546	Belongs to the CinA family
G4Q83_04375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G4Q83_04380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G4Q83_04385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G4Q83_04390	COG2137	regulation of response to DNA damage stimulus
G4Q83_04395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G4Q83_04400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G4Q83_04430	COG0588	phosphoglycerate mutase activity
G4Q83_04460	COG1741	Belongs to the pirin family
G4Q83_04470	COG1741	Belongs to the pirin family
G4Q83_04475	COG1966	Carbon starvation protein
G4Q83_04480	COG2879	small protein
G4Q83_04520	COG0488	(ABC) transporter
G4Q83_04525	COG0513	Belongs to the DEAD box helicase family
G4Q83_04570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G4Q83_04590	COG1024	Enoyl-CoA hydratase
G4Q83_04625	COG0505	Belongs to the CarA family
G4Q83_04635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G4Q83_04640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4Q83_04650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G4Q83_04730	COG2963	transposase activity
G4Q83_04795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4Q83_04805	COG0784	Response regulator, receiver
G4Q83_04805	COG2198	Histidine kinase
G4Q83_04805	COG2205	protein histidine kinase activity
G4Q83_04810	COG1024	Enoyl-CoA hydratase
G4Q83_04815	COG0318	PFAM AMP-dependent synthetase and ligase
G4Q83_04860	COG0840	transmembrane signaling receptor activity
G4Q83_04870	COG0840	transmembrane signaling receptor activity
G4Q83_04880	COG0835	chemotaxis
G4Q83_04895	COG0840	transmembrane signaling receptor activity
G4Q83_04900	COG0840	transmembrane signaling receptor activity
G4Q83_04910	COG0745	RESPONSE REGULATOR receiver
G4Q83_04925	COG1192	Involved in chromosome partitioning
G4Q83_04930	COG1360	Flagellar Motor Protein
G4Q83_04935	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G4Q83_04940	COG0643	Histidine kinase
G4Q83_04940	COG2198	Histidine kinase
G4Q83_04940	COG0784	Response regulator, receiver
G4Q83_04990	COG2267	carboxylic ester hydrolase activity
G4Q83_04995	COG1733	regulation of RNA biosynthetic process
G4Q83_05015	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_05025	COG3657	addiction module killer protein
G4Q83_05040	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
G4Q83_05045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G4Q83_05055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4Q83_05095	COG1136	(ABC) transporter
G4Q83_05095	COG0577	efflux transmembrane transporter activity
G4Q83_05125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4Q83_05125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4Q83_05130	COG1105	Belongs to the carbohydrate kinase PfkB family
G4Q83_05135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4Q83_05135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4Q83_05140	COG1609	Transcriptional regulator
G4Q83_05160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G4Q83_05180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4Q83_05280	COG0537	adenosine 5'-monophosphoramidase activity
G4Q83_05300	COG0714	Associated with various cellular activities
G4Q83_05365	COG0714	Associated with various cellular activities
G4Q83_05395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G4Q83_05425	COG1294	oxidase, subunit
G4Q83_05435	COG4988	ABC transporter
G4Q83_05440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G4Q83_05445	COG1404	Belongs to the peptidase S8 family
G4Q83_05450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G4Q83_05455	COG3385	transposase activity
G4Q83_05480	COG0488	(ABC) transporter
G4Q83_05535	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G4Q83_05565	COG4221	oxidoreductase activity
G4Q83_05605	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G4Q83_05610	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G4Q83_05615	COG1605	Chorismate mutase
G4Q83_05615	COG0077	Prephenate dehydratase
G4Q83_05635	COG0519	Catalyzes the synthesis of GMP from XMP
G4Q83_05650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G4Q83_05675	COG1113	amino acid transport
G4Q83_05695	COG2239	Acts as a magnesium transporter
G4Q83_05700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4Q83_05705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4Q83_05715	COG1660	Displays ATPase and GTPase activities
G4Q83_05725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4Q83_05740	COG1137	ATPase activity
G4Q83_05755	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G4Q83_05790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G4Q83_05815	COG0628	permease
G4Q83_05825	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G4Q83_05830	COG3178	'Phosphotransferase
G4Q83_05845	COG1555	photosystem II stabilization
G4Q83_05895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4Q83_05900	COG1846	Transcriptional regulator
G4Q83_05905	COG0339	signal peptide processing
G4Q83_05910	COG0386	Belongs to the glutathione peroxidase family
G4Q83_05945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4Q83_05950	COG1595	DNA-templated transcription, initiation
G4Q83_05960	COG0625	glutathione transferase activity
G4Q83_05990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G4Q83_05995	COG0084	hydrolase, TatD family'
G4Q83_06025	COG0305	Participates in initiation and elongation during chromosome replication
G4Q83_06035	COG0415	Belongs to the DNA photolyase family
G4Q83_06050	COG0583	DNA-binding transcription factor activity
G4Q83_06065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4Q83_06085	COG3706	GGDEF domain
G4Q83_06140	COG2336	PFAM SpoVT AbrB
G4Q83_06170	COG0859	PFAM glycosyl transferase family 9
G4Q83_06180	COG1234	tRNA 3'-trailer cleavage
G4Q83_06185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G4Q83_06190	COG0315	cyclic pyranopterin monophosphate synthase activity
G4Q83_06195	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G4Q83_06200	COG0314	molybdopterin synthase activity
G4Q83_06225	COG0735	belongs to the Fur family
G4Q83_06260	COG0552	protein localization to endoplasmic reticulum
G4Q83_06270	COG3938	Belongs to the proline racemase family
G4Q83_06275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4Q83_06290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4Q83_06300	COG0006	proline dipeptidase activity
G4Q83_06315	COG0531	amino acid
G4Q83_06385	COG1012	belongs to the aldehyde dehydrogenase family
G4Q83_06390	COG1879	ABC-type sugar transport system periplasmic component
G4Q83_06395	COG1129	ABC transporter
G4Q83_06400	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Q83_06405	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Q83_06435	COG0475	glutathione-regulated potassium exporter activity
G4Q83_06470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G4Q83_06505	COG1477	protein flavinylation
G4Q83_06530	COG4774	siderophore transport
G4Q83_06545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4Q83_06550	COG0719	Fe-S assembly protein
G4Q83_06555	COG0396	ATPase activity
G4Q83_06565	COG0719	Fe-S assembly protein
G4Q83_06580	COG0693	protein deglycase activity
G4Q83_06595	COG0739	heme binding
G4Q83_06610	COG1764	response to oxidative stress
G4Q83_06620	COG0384	phenazine biosynthesis protein PhzF
G4Q83_06625	COG0527	aspartate kinase activity
G4Q83_06650	COG0142	geranyltranstransferase activity
G4Q83_06655	COG0629	single-stranded DNA binding
G4Q83_06660	COG3279	Response regulator of the LytR AlgR family
G4Q83_06695	COG0405	Gamma-glutamyltransferase
G4Q83_06700	COG4206	TonB-dependent receptor
G4Q83_06705	COG1297	OPT oligopeptide transporter protein
G4Q83_06710	COG1506	peptidase
G4Q83_06710	COG0823	Involved in the tonB-independent uptake of proteins
G4Q83_06770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G4Q83_06785	COG1960	acyl-CoA dehydrogenase activity
G4Q83_06795	COG1566	PFAM secretion protein HlyD family protein
G4Q83_06850	COG2915	High frequency lysogenization protein hflD homolog
G4Q83_06855	COG0482	sulfurtransferase activity
G4Q83_06875	COG0542	response to heat
G4Q83_06905	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G4Q83_06930	COG1674	ftsk spoiiie
G4Q83_06940	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G4Q83_06950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G4Q83_06955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G4Q83_06990	COG4651	solute:proton antiporter activity
G4Q83_06990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4Q83_07035	COG4264	IucA IucC family
G4Q83_07040	COG2814	Major facilitator Superfamily
G4Q83_07045	COG4264	IucA IucC family
G4Q83_07050	COG0019	diaminopimelate decarboxylase activity
G4Q83_07055	COG2223	nitrite transmembrane transporter activity
G4Q83_07080	COG0542	response to heat
G4Q83_07105	COG0454	-acetyltransferase
G4Q83_07135	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G4Q83_07145	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G4Q83_07150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G4Q83_07205	COG2211	Major facilitator Superfamily
G4Q83_07235	COG0835	chemotaxis
G4Q83_07240	COG0840	transmembrane signaling receptor activity
G4Q83_07250	COG0643	Histidine kinase
G4Q83_07250	COG2198	Histidine kinase
G4Q83_07265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G4Q83_07285	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G4Q83_07300	COG0642	Histidine kinase
G4Q83_07305	COG3111	PFAM Bacterial OB fold (BOF) protein
G4Q83_07360	COG3702	type iv secretory pathway
G4Q83_07390	COG3409	Peptidoglycan-binding domain 1 protein
G4Q83_07390	COG3267	Type II secretory pathway component ExeA
G4Q83_07410	COG3409	Peptidoglycan-binding domain 1 protein
G4Q83_07410	COG3773	Cell wall hydrolase
G4Q83_07450	COG2925	Exonuclease
G4Q83_07460	COG3844	kynureninase activity
G4Q83_07475	COG0288	reversible hydration of carbon dioxide
G4Q83_07505	COG0017	Asparaginyl-tRNA synthetase
G4Q83_07510	COG0316	Belongs to the HesB IscA family
G4Q83_07515	COG2977	Belongs to the P-Pant transferase superfamily
G4Q83_07525	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G4Q83_07540	COG3115	cell septum assembly
G4Q83_07550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G4Q83_07595	COG0124	histidyl-tRNA synthetase
G4Q83_07605	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G4Q83_07610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G4Q83_07625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G4Q83_07640	COG0140	phosphoribosyl-ATP diphosphatase activity
G4Q83_07640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G4Q83_07660	COG5265	(ABC) transporter
G4Q83_07685	COG1131	(ABC) transporter
G4Q83_07730	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
G4Q83_07735	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
G4Q83_07745	COG0531	amino acid
G4Q83_07750	COG0531	amino acid
G4Q83_07765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4Q83_07770	COG0277	FAD linked oxidase domain protein
G4Q83_07780	COG1914	H( )-stimulated, divalent metal cation uptake system
G4Q83_07785	COG1321	iron dependent repressor
G4Q83_07795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G4Q83_07800	COG0668	transmembrane transport
G4Q83_07810	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G4Q83_07825	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_07830	COG1183	phosphatidylcholine synthase activity
G4Q83_07840	COG3243	poly(R)-hydroxyalkanoic acid synthase
G4Q83_07860	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G4Q83_07860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4Q83_07870	COG2183	response to ionizing radiation
G4Q83_07905	COG2801	Transposase and inactivated derivatives
G4Q83_07920	COG1002	Type II restriction enzyme, methylase subunits
G4Q83_07950	COG0583	DNA-binding transcription factor activity
G4Q83_07970	COG1070	Carbohydrate kinase
G4Q83_07975	COG2115	Belongs to the xylose isomerase family
G4Q83_07980	COG0477	Major facilitator Superfamily
G4Q83_08000	COG0617	tRNA 3'-terminal CCA addition
G4Q83_08005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G4Q83_08010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G4Q83_08025	COG0166	Belongs to the GPI family
G4Q83_08045	COG0840	transmembrane signaling receptor activity
G4Q83_08060	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
G4Q83_08075	COG0671	phosphoesterase, PA-phosphatase related
G4Q83_08150	COG0475	glutathione-regulated potassium exporter activity
G4Q83_08150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4Q83_08160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G4Q83_08170	COG0746	molybdenum cofactor guanylyltransferase activity
G4Q83_08180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4Q83_08185	COG2976	Protein conserved in bacteria
G4Q83_08190	COG1426	Protein conserved in bacteria
G4Q83_08200	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G4Q83_08215	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4Q83_08215	COG1024	Enoyl-CoA hydratase
G4Q83_08220	COG0183	Belongs to the thiolase family
G4Q83_08225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4Q83_08235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4Q83_08240	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G4Q83_08250	COG0776	regulation of translation
G4Q83_08255	COG0539	negative regulation of cytoplasmic translation
G4Q83_08260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G4Q83_08265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G4Q83_08275	COG2957	Belongs to the agmatine deiminase family
G4Q83_08280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4Q83_08305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4Q83_08345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G4Q83_08345	COG0316	Belongs to the HesB IscA family
G4Q83_08360	COG0428	transporter
G4Q83_08365	COG3064	Membrane
G4Q83_08375	COG1530	ribonuclease E activity
G4Q83_08390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G4Q83_08415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4Q83_08430	COG1024	Enoyl-CoA hydratase
G4Q83_08430	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4Q83_08435	COG3706	GGDEF domain
G4Q83_08490	COG1643	Atp-dependent helicase
G4Q83_08495	COG0783	Belongs to the Dps family
G4Q83_08510	COG0514	ATP-dependent DNA helicase (RecQ)
G4Q83_08570	COG1196	nuclear chromosome segregation
G4Q83_08665	COG3179	chitinase
G4Q83_08670	COG3657	addiction module killer protein
G4Q83_08840	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G4Q83_08845	COG0602	queuosine metabolic process
G4Q83_08855	COG2885	chlorophyll binding
G4Q83_08870	COG0848	biopolymer transport protein
G4Q83_08880	COG0824	Thioesterase
G4Q83_08890	COG3158	transport of potassium into the cell
G4Q83_08895	COG0632	four-way junction helicase activity
G4Q83_08905	COG0217	transcriptional regulatory protein
G4Q83_08920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4Q83_08935	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G4Q83_08970	COG0488	(ABC) transporter
G4Q83_09020	COG0372	Belongs to the citrate synthase family
G4Q83_09030	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_09060	COG2086	electron transfer activity
G4Q83_09075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G4Q83_09075	COG0546	phosphoglycolate phosphatase activity
G4Q83_09080	COG0277	FAD linked oxidase domain protein
G4Q83_09085	COG0300	oxidoreductase activity
G4Q83_09095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4Q83_09125	COG3754	Rhamnan synthesis protein F
G4Q83_09130	COG1216	Glycosyl transferase, family 2
G4Q83_09130	COG0438	transferase activity, transferring glycosyl groups
G4Q83_09150	COG0626	cystathionine gamma-synthase activity
G4Q83_09180	COG0625	glutathione transferase activity
G4Q83_09190	COG0513	Belongs to the DEAD box helicase family
G4Q83_09195	COG0720	synthase
G4Q83_09295	COG2197	response regulator
G4Q83_09300	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G4Q83_09305	COG2201	protein-glutamate methylesterase activity
G4Q83_09325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4Q83_09330	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_09335	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_09395	COG1677	Flagellar hook-basal body complex protein FliE
G4Q83_09405	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4Q83_09445	COG3190	flagellar
G4Q83_09460	COG1684	flagellar biosynthetic protein fliR
G4Q83_09475	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_09530	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
G4Q83_09540	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
G4Q83_09545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G4Q83_09560	COG0460	homoserine dehydrogenase
G4Q83_09560	COG0527	aspartate kinase activity
G4Q83_09615	COG1012	belongs to the aldehyde dehydrogenase family
G4Q83_09635	COG0167	dihydroorotate dehydrogenase activity
G4Q83_09640	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G4Q83_09655	COG2205	protein histidine kinase activity
G4Q83_09680	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G4Q83_09685	COG5002	protein histidine kinase activity
G4Q83_09690	COG0745	RESPONSE REGULATOR receiver
G4Q83_09695	COG4774	siderophore transport
G4Q83_09700	COG0174	glutamine synthetase
G4Q83_09710	COG0174	glutamine synthetase
G4Q83_09715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4Q83_09725	COG0477	Major facilitator Superfamily
G4Q83_09745	COG2223	nitrite transmembrane transporter activity
G4Q83_09765	COG1012	belongs to the aldehyde dehydrogenase family
G4Q83_09770	COG1396	sequence-specific DNA binding
G4Q83_09770	COG1917	Cupin 2, conserved barrel domain protein
G4Q83_09775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G4Q83_09785	COG2733	membrane
G4Q83_09805	COG0582	viral genome integration into host DNA
G4Q83_09880	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G4Q83_09885	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_09890	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G4Q83_09895	COG0534	Mate efflux family protein
G4Q83_09900	COG0335	large ribosomal subunit rRNA binding
G4Q83_09910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G4Q83_09925	COG2070	2-Nitropropane dioxygenase
G4Q83_09950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G4Q83_09965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G4Q83_10020	COG0351	phosphomethylpyrimidine kinase
G4Q83_10035	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G4Q83_10040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G4Q83_10050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4Q83_10140	COG3275	phosphorelay sensor kinase activity
G4Q83_10145	COG1611	Belongs to the LOG family
G4Q83_10155	COG2095	MarC family integral membrane protein
G4Q83_10160	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_10165	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G4Q83_10205	COG2969	positive regulation of protein catabolic process
G4Q83_10210	COG0625	glutathione transferase activity
G4Q83_10215	COG2857	Cytochrome c1
G4Q83_10220	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G4Q83_10225	COG0723	plastoquinol--plastocyanin reductase activity
G4Q83_10230	COG0741	lytic transglycosylase activity
G4Q83_10260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4Q83_10270	COG1702	phosphate starvation-inducible protein PhoH
G4Q83_10295	COG4535	Mg2 and Co2 transporter CorC
G4Q83_10310	COG1012	belongs to the aldehyde dehydrogenase family
G4Q83_10315	COG1177	transmembrane transport
G4Q83_10320	COG1176	ABC-type spermidine putrescine transport system, permease component I
G4Q83_10325	COG3842	ATPase activity
G4Q83_10345	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G4Q83_10365	COG2902	Dehydrogenase
G4Q83_10375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4Q83_10380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4Q83_10385	COG1960	acyl-CoA dehydrogenase activity
G4Q83_10390	COG2226	methyltransferase
G4Q83_10395	COG0646	methionine synthase
G4Q83_10395	COG1410	methionine synthase
G4Q83_10400	COG1410	methionine synthase
G4Q83_10400	COG0646	methionine synthase
G4Q83_10415	COG2755	lipolytic protein G-D-S-L family
G4Q83_10415	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G4Q83_10425	COG2900	Belongs to the SlyX family
G4Q83_10440	COG0386	Belongs to the glutathione peroxidase family
G4Q83_10450	COG1725	Transcriptional regulator
G4Q83_10455	COG1131	(ABC) transporter
G4Q83_10490	COG2850	peptidyl-arginine hydroxylation
G4Q83_10520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4Q83_10530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G4Q83_10555	COG0800	Aldolase
G4Q83_10570	COG3734	2-keto-3-deoxy-galactonokinase
G4Q83_10575	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G4Q83_10605	COG0556	nucleotide-excision repair
G4Q83_10685	COG3273	potassium ion transport
G4Q83_10685	COG0471	metal ion transport
G4Q83_10700	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4Q83_10720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4Q83_10740	COG0438	transferase activity, transferring glycosyl groups
G4Q83_10750	COG0529	Catalyzes the synthesis of activated sulfate
G4Q83_10750	COG2895	sulfate adenylyltransferase (ATP) activity
G4Q83_10760	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G4Q83_10765	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4Q83_10770	COG0175	sulfate reduction
G4Q83_10790	COG0840	transmembrane signaling receptor activity
G4Q83_10825	COG3588	fructose-bisphosphate aldolase
G4Q83_10850	COG0725	ABC transporter, periplasmic molybdate-binding protein
G4Q83_10855	COG4149	molybdate abc transporter
G4Q83_10860	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G4Q83_10885	COG0427	acetyl-CoA hydrolase
G4Q83_10905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G4Q83_10910	COG1301	dicarboxylic acid transport
G4Q83_10980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G4Q83_11010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4Q83_11015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G4Q83_11020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G4Q83_11040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G4Q83_11045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4Q83_11050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G4Q83_11055	COG1399	metal-binding, possibly nucleic acid-binding protein
G4Q83_11090	COG0254	rRNA binding
G4Q83_11100	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G4Q83_11110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4Q83_11115	COG1758	RNA polymerase activity
G4Q83_11165	COG0625	glutathione transferase activity
G4Q83_11180	COG4681	YaeQ
G4Q83_11185	COG2081	HI0933 family
G4Q83_11205	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_11240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G4Q83_11245	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4Q83_11250	COG0802	atpase or kinase
G4Q83_11255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G4Q83_11255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G4Q83_11260	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G4Q83_11275	COG3040	lipid binding
G4Q83_11285	COG2161	toxin-antitoxin pair type II binding
G4Q83_11290	COG4115	mRNA cleavage
G4Q83_11300	COG5001	Diguanylate cyclase
G4Q83_11305	COG1595	DNA-templated transcription, initiation
G4Q83_11320	COG1132	(ABC) transporter
G4Q83_11330	COG1605	Chorismate mutase
G4Q83_11330	COG0287	Prephenate dehydrogenase
G4Q83_11335	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
G4Q83_11340	COG0484	heat shock protein binding
G4Q83_11345	COG0443	Heat shock 70 kDa protein
G4Q83_11350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G4Q83_11355	COG1420	regulation of RNA biosynthetic process
G4Q83_11360	COG0497	DNA recombination
G4Q83_11365	COG0735	belongs to the Fur family
G4Q83_11370	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4Q83_11380	COG2867	negative regulation of translational initiation
G4Q83_11385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G4Q83_11390	COG3385	transposase activity
G4Q83_11430	COG2197	response regulator
G4Q83_11480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4Q83_11525	COG4790	Type iii secretion
G4Q83_11570	COG2207	Transcriptional regulator
G4Q83_11620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4Q83_11630	COG1534	Rna-binding protein
G4Q83_11655	COG1238	metal cluster binding
G4Q83_11660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G4Q83_11665	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G4Q83_11670	COG2840	Smr protein MutS2
G4Q83_11680	COG0585	pseudouridine synthase activity
G4Q83_11685	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G4Q83_11690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G4Q83_11705	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G4Q83_11710	COG0504	CTP synthase activity
G4Q83_11725	COG1879	ABC-type sugar transport system periplasmic component
G4Q83_11745	COG0840	transmembrane signaling receptor activity
G4Q83_11770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G4Q83_11805	COG2878	Part of a membrane complex involved in electron transport
G4Q83_11820	COG1595	DNA-templated transcription, initiation
G4Q83_11835	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
G4Q83_11845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4Q83_11865	COG0251	oxidation-reduction process
G4Q83_11875	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
G4Q83_11875	COG0392	lysyltransferase activity
G4Q83_11910	COG2814	Major facilitator Superfamily
G4Q83_11915	COG1902	pentaerythritol trinitrate reductase activity
G4Q83_11925	COG2824	Alkylphosphonate utilization operon protein PhnA
G4Q83_11975	COG0443	Heat shock 70 kDa protein
G4Q83_11995	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G4Q83_12015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G4Q83_12050	COG5487	UPF0391 membrane protein
G4Q83_12125	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_12195	COG3142	Participates in the control of copper homeostasis
G4Q83_12200	COG1446	asparaginase
G4Q83_12210	COG1561	YicC-like family, N-terminal region
G4Q83_12215	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G4Q83_12220	COG0346	lactoylglutathione lyase activity
G4Q83_12235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4Q83_12285	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G4Q83_12300	COG0165	Argininosuccinate lyase
G4Q83_12315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G4Q83_12320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Q83_12330	COG0137	argininosuccinate synthase activity
G4Q83_12335	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4Q83_12350	COG2166	iron-sulfur cluster assembly
G4Q83_12405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G4Q83_12420	COG4303	Ethanolamine ammonia lyase large subunit
G4Q83_12425	COG4302	ethanolamine ammonia-lyase activity
G4Q83_12440	COG5434	Belongs to the glycosyl hydrolase 28 family
G4Q83_12460	COG0402	S-adenosylhomocysteine deaminase activity
G4Q83_12475	COG1509	lysine 2,3-aminomutase activity
G4Q83_12505	COG0583	DNA-binding transcription factor activity
G4Q83_12525	COG0671	phosphoesterase, PA-phosphatase related
G4Q83_12540	COG2211	Major facilitator Superfamily
G4Q83_12555	COG1862	Preprotein translocase
G4Q83_12575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4Q83_12580	COG1309	transcriptional regulator
G4Q83_12590	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G4Q83_12605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4Q83_12610	COG0405	Gamma-glutamyltransferase
G4Q83_12615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4Q83_12635	COG0742	ribosomal rna small subunit methyltransferase
G4Q83_12640	COG0326	Molecular chaperone. Has ATPase activity
G4Q83_12685	COG2072	flavoprotein involved in K transport
G4Q83_12700	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_12710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4Q83_12730	COG0306	phosphate transporter
G4Q83_12740	COG1253	flavin adenine dinucleotide binding
G4Q83_12750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Q83_12805	COG1663	tetraacyldisaccharide 4'-kinase activity
G4Q83_12810	COG1132	(ABC) transporter
G4Q83_12820	COG0811	peptide transport
G4Q83_12840	COG4591	ABC-type transport system involved in lipoprotein release permease component
G4Q83_12855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G4Q83_12865	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G4Q83_12870	COG2009	succinate dehydrogenase
G4Q83_12880	COG0354	folic acid binding
G4Q83_12890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G4Q83_12905	COG0129	dihydroxy-acid dehydratase activity
G4Q83_12910	COG0800	Aldolase
G4Q83_12920	COG0395	ABC-type sugar transport system, permease component
G4Q83_12955	COG2350	Protein conserved in bacteria
G4Q83_12960	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G4Q83_12965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G4Q83_12970	COG1187	pseudouridine synthase activity
G4Q83_12995	COG0436	Aminotransferase
G4Q83_13000	COG4133	protoheme IX ABC transporter activity
G4Q83_13065	COG1024	Enoyl-CoA hydratase
G4Q83_13075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G4Q83_13090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G4Q83_13095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G4Q83_13100	COG0573	inorganic phosphate transmembrane transporter activity
G4Q83_13105	COG0581	inorganic phosphate transmembrane transporter activity
G4Q83_13115	COG0704	Plays a role in the regulation of phosphate uptake
G4Q83_13140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4Q83_13150	COG2205	protein histidine kinase activity
G4Q83_13175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4Q83_13185	COG0557	exoribonuclease II activity
G4Q83_13250	COG2197	response regulator
G4Q83_13265	COG2814	Major facilitator Superfamily
G4Q83_13270	COG1566	PFAM secretion protein HlyD family protein
G4Q83_13305	COG0367	asparagine synthase
G4Q83_13310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Q83_13315	COG1393	Belongs to the ArsC family
G4Q83_13330	COG0024	Methionine aminopeptidase
G4Q83_13365	COG0052	Belongs to the universal ribosomal protein uS2 family
G4Q83_13385	COG0528	UMP kinase activity
G4Q83_13405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G4Q83_13410	COG0575	Belongs to the CDS family
G4Q83_13415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G4Q83_13420	COG0750	zinc metalloprotease
G4Q83_13425	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4Q83_13440	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G4Q83_13460	COG0825	malonyl-CoA metabolic process
G4Q83_13465	COG1981	membrane
G4Q83_13535	COG1132	(ABC) transporter
G4Q83_13590	COG1187	pseudouridine synthase activity
G4Q83_13620	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_13710	COG3039	Transposase
G4Q83_13725	COG1196	nuclear chromosome segregation
G4Q83_13740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G4Q83_13750	COG0494	nUDIX hydrolase
G4Q83_13770	COG0653	protein targeting
G4Q83_13775	COG0739	heme binding
G4Q83_13800	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G4Q83_13805	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4Q83_13830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G4Q83_13845	COG3116	cell division
G4Q83_13850	COG0275	rRNA processing
G4Q83_13855	COG2001	Belongs to the MraZ family
G4Q83_13910	COG0792	nuclease activity
G4Q83_13915	COG0277	FAD linked oxidase domain protein
G4Q83_13925	COG0745	RESPONSE REGULATOR receiver
G4Q83_13930	COG2205	protein histidine kinase activity
G4Q83_13940	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
G4Q83_13945	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G4Q83_13965	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G4Q83_13970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4Q83_13975	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G4Q83_13990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4Q83_13990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4Q83_14040	COG1877	trehalose-phosphatase activity
G4Q83_14045	COG3387	PFAM Glycoside hydrolase 15-related
G4Q83_14075	COG0564	pseudouridine synthase activity
G4Q83_14080	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4Q83_14090	COG1125	glycine betaine transport
G4Q83_14095	COG1174	glycine betaine transport
G4Q83_14105	COG1450	Type ii and iii secretion system protein
G4Q83_14120	COG3166	PFAM Fimbrial assembly family protein
G4Q83_14125	COG3156	type II secretion system protein K
G4Q83_14130	COG4795	General secretion pathway protein
G4Q83_14135	COG2165	general secretion pathway protein
G4Q83_14140	COG4970	Tfp pilus assembly protein FimT
G4Q83_14145	COG2165	general secretion pathway protein
G4Q83_14150	COG1459	type II secretion system
G4Q83_14155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G4Q83_14160	COG0047	phosphoribosylformylglycinamidine synthase activity
G4Q83_14160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4Q83_14165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4Q83_14170	COG4974	Belongs to the 'phage' integrase family
G4Q83_14190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G4Q83_14195	COG2927	DNA polymerase III (CHI subunit)
G4Q83_14230	COG2175	clavaminate synthase activity
G4Q83_14250	COG0456	acetyltransferase
G4Q83_14270	COG1183	phosphatidylcholine synthase activity
G4Q83_14280	COG0442	prolyl-tRNA aminoacylation
G4Q83_14295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4Q83_14300	COG1127	ABC transporter
G4Q83_14305	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G4Q83_14305	COG3218	ABC-type transport auxiliary lipoprotein component
G4Q83_14345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4Q83_14355	COG0328	RNA-DNA hybrid ribonuclease activity
G4Q83_14360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4Q83_14365	COG0631	protein serine/threonine phosphatase activity
G4Q83_14390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4Q83_14430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4Q83_14470	COG0544	peptidyl-prolyl cis-trans isomerase activity
G4Q83_14510	COG0473	3-isopropylmalate dehydrogenase activity
G4Q83_14525	COG4783	chaperone-mediated protein folding
G4Q83_14530	COG0745	RESPONSE REGULATOR receiver
G4Q83_14540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G4Q83_14545	COG0248	Ppx GppA phosphatase
G4Q83_14550	COG0438	transferase activity, transferring glycosyl groups
G4Q83_14560	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G4Q83_14575	COG2833	Protein of unknown function (DUF455)
G4Q83_14595	COG0285	dihydrofolate synthase activity
G4Q83_14600	COG0588	phosphoglycerate mutase activity
G4Q83_14635	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G4Q83_14640	COG4208	sulfate ABC transporter
G4Q83_14645	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G4Q83_14650	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G4Q83_14655	COG0156	8-amino-7-oxononanoate synthase activity
G4Q83_14660	COG1187	pseudouridine synthase activity
G4Q83_14670	COG2885	chlorophyll binding
G4Q83_14675	COG0583	DNA-binding transcription factor activity
G4Q83_14680	COG2814	Major facilitator Superfamily
G4Q83_14690	COG0667	Aldo Keto reductase
G4Q83_14700	COG1902	pentaerythritol trinitrate reductase activity
G4Q83_14700	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4Q83_14735	COG0625	glutathione transferase activity
G4Q83_14750	COG2249	NAD(P)H dehydrogenase (quinone) activity
G4Q83_14770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4Q83_14775	COG1217	gtp-binding protein TYPA
G4Q83_14790	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G4Q83_14800	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G4Q83_14805	COG0203	ribosomal protein L17
G4Q83_14815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G4Q83_14830	COG0201	protein transport
G4Q83_14840	COG1841	ribosomal large subunit assembly
G4Q83_14850	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G4Q83_14865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G4Q83_14870	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G4Q83_14875	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G4Q83_14885	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G4Q83_14890	COG0255	Belongs to the universal ribosomal protein uL29 family
G4Q83_14905	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G4Q83_14915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G4Q83_14920	COG0089	rRNA binding
G4Q83_14925	COG0088	Forms part of the polypeptide exit tunnel
G4Q83_14935	COG0051	transcription antitermination factor activity, RNA binding
G4Q83_14940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G4Q83_14945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G4Q83_14960	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G4Q83_14970	COG0222	ribosome binding
G4Q83_14995	COG0250	Participates in transcription elongation, termination and antitermination
G4Q83_15010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G4Q83_15030	COG0469	pyruvate kinase activity
G4Q83_15080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4Q83_15085	COG3047	cAMP biosynthetic process
G4Q83_15115	COG0625	glutathione transferase activity
G4Q83_15170	COG4555	ABC transporter
G4Q83_15180	COG1476	TRANSCRIPTIONal
G4Q83_15190	COG0633	Ferredoxin
G4Q83_15190	COG0543	2 iron, 2 sulfur cluster binding
G4Q83_15195	COG1131	(ABC) transporter
G4Q83_15200	COG0842	Transport permease protein
G4Q83_15205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G4Q83_15205	COG1648	precorrin-2 dehydrogenase activity
G4Q83_15300	COG2353	YceI-like domain
G4Q83_15330	COG0584	glycerophosphoryl diester phosphodiesterase
G4Q83_15355	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G4Q83_15430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4Q83_15435	COG1960	acyl-CoA dehydrogenase activity
G4Q83_15445	COG3245	cytochrome
G4Q83_15460	COG0523	cobalamin synthesis protein
G4Q83_15475	COG1196	nuclear chromosome segregation
G4Q83_15475	COG3264	Mechanosensitive ion channel
G4Q83_15480	COG0604	alcohol dehydrogenase
G4Q83_15480	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_15480	COG3321	synthase
G4Q83_15490	COG1802	Transcriptional regulator
G4Q83_15505	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
G4Q83_15550	COG1414	Transcriptional regulator
G4Q83_15555	COG0738	Major facilitator superfamily
G4Q83_15560	COG3254	rhamnose metabolic process
G4Q83_15575	COG0793	Belongs to the peptidase S41A family
G4Q83_15580	COG4942	peptidase
G4Q83_15590	COG2234	aminopeptidase activity
G4Q83_15635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G4Q83_15635	COG0519	Catalyzes the synthesis of GMP from XMP
G4Q83_15640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G4Q83_15660	COG0210	DNA helicase
G4Q83_15665	COG1435	thymidine kinase activity
G4Q83_15670	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G4Q83_15680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4Q83_15695	COG2186	Transcriptional regulator
G4Q83_15700	COG1304	FMN binding
G4Q83_15705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4Q83_15710	COG0697	spore germination
G4Q83_15750	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
G4Q83_15760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G4Q83_15775	COG3385	transposase activity
G4Q83_15785	COG0840	transmembrane signaling receptor activity
G4Q83_15810	COG0308	aminopeptidase N
G4Q83_15815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G4Q83_15825	COG2226	methyltransferase
G4Q83_15845	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G4Q83_15875	COG2832	Protein of unknown function (DUF454)
G4Q83_15885	COG0436	Aminotransferase
G4Q83_15900	COG1505	serine-type exopeptidase activity
G4Q83_15930	COG0181	hydroxymethylbilane synthase activity
G4Q83_15955	COG2204	response regulator
G4Q83_15970	COG2963	transposase activity
G4Q83_16065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4Q83_16070	COG1490	D-aminoacyl-tRNA deacylase activity
G4Q83_16075	COG1560	Kdo2-lipid A biosynthetic process
G4Q83_16085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4Q83_16095	COG1324	tolerance protein
G4Q83_16100	COG2356	endonuclease I
G4Q83_16110	COG0459	protein refolding
G4Q83_16120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G4Q83_16130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G4Q83_16160	COG2267	carboxylic ester hydrolase activity
G4Q83_16190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Q83_16195	COG1077	Cell shape determining protein MreB Mrl
G4Q83_16200	COG1792	Involved in formation and maintenance of cell shape
G4Q83_16210	COG0768	penicillin binding
G4Q83_16215	COG0772	Belongs to the SEDS family
G4Q83_16240	COG2951	lytic endotransglycosylase activity
G4Q83_16245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G4Q83_16250	COG1686	Belongs to the peptidase S11 family
G4Q83_16270	COG2921	Belongs to the UPF0250 family
G4Q83_16280	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G4Q83_16330	COG0667	Aldo Keto reductase
G4Q83_16335	COG0667	Aldo Keto reductase
G4Q83_16350	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_16365	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G4Q83_16375	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
G4Q83_16390	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
G4Q83_16395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4Q83_16410	COG0463	Glycosyl transferase, family 2
G4Q83_16425	COG1475	DNA binding
G4Q83_16430	COG1192	Involved in chromosome partitioning
G4Q83_16435	COG0357	Ribosomal RNA small subunit methyltransferase G
G4Q83_16440	COG2091	lysine biosynthetic process via aminoadipic acid
G4Q83_16505	COG1971	Probably functions as a manganese efflux pump
G4Q83_16520	COG2205	protein histidine kinase activity
G4Q83_16525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4Q83_16550	COG2937	Belongs to the GPAT DAPAT family
G4Q83_16555	COG2937	Belongs to the GPAT DAPAT family
G4Q83_16590	COG0284	orotidine-5'-phosphate decarboxylase activity
G4Q83_16595	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
G4Q83_16600	COG3265	gluconokinase activity
G4Q83_16640	COG0840	transmembrane signaling receptor activity
G4Q83_16650	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G4Q83_16660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4Q83_16670	COG0805	protein transport
G4Q83_16685	COG3384	dioxygenase
G4Q83_16730	COG0473	3-isopropylmalate dehydrogenase activity
G4Q83_16735	COG0066	3-isopropylmalate dehydratase activity
G4Q83_16745	COG4106	trans-aconitate 2-methyltransferase activity
G4Q83_16750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4Q83_16770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G4Q83_16800	COG3568	Endonuclease Exonuclease Phosphatase
G4Q83_16805	COG0392	lysyltransferase activity
G4Q83_16850	COG1940	carbohydrate kinase activity
G4Q83_16895	COG1597	lipid kinase activity
G4Q83_16915	COG0484	heat shock protein binding
G4Q83_16940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4Q83_16940	COG2111	Na H antiporter
G4Q83_16945	COG1006	Multisubunit Na H antiporter MnhC subunit
G4Q83_16950	COG0651	ATP synthesis coupled electron transport
G4Q83_16960	COG2212	antiporter activity
G4Q83_16965	COG1320	monovalent cation:proton antiporter activity
G4Q83_17005	COG3104	oligopeptide transport
G4Q83_17010	COG3483	tryptophan 2,3-dioxygenase activity
G4Q83_17050	COG4191	Histidine kinase
G4Q83_17055	COG0784	Response regulator, receiver
G4Q83_17060	COG2202	Pas domain
G4Q83_17060	COG2205	protein histidine kinase activity
G4Q83_17070	COG2823	Periplasmic or secreted lipoprotein
G4Q83_17075	COG0673	inositol 2-dehydrogenase activity
G4Q83_17080	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G4Q83_17090	COG1090	epimerase
G4Q83_17160	COG4772	TonB-dependent receptor
G4Q83_17215	COG0045	succinate-CoA ligase (ADP-forming) activity
G4Q83_17215	COG1042	CoA-binding domain protein
G4Q83_17215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Q83_17250	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G4Q83_17315	COG0367	asparagine synthase
G4Q83_17350	COG1132	(ABC) transporter
G4Q83_17375	COG0531	amino acid
G4Q83_17390	COG5297	Belongs to the glycosyl hydrolase family 6
G4Q83_17390	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
G4Q83_17395	COG0612	Peptidase, M16
G4Q83_17445	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G4Q83_17485	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
G4Q83_17490	COG2207	Transcriptional regulator
G4Q83_17500	COG0598	Magnesium transport protein CorA
G4Q83_17505	COG1113	amino acid transport
G4Q83_17510	COG0697	spore germination
G4Q83_17535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4Q83_17565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G4Q83_17570	COG0134	indole-3-glycerol-phosphate synthase activity
G4Q83_17605	COG0069	glutamate synthase activity
G4Q83_17605	COG0070	glutamate synthase
G4Q83_17605	COG0067	glutamate synthase
G4Q83_17610	COG0493	'glutamate synthase
G4Q83_17670	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G4Q83_17675	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G4Q83_17675	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G4Q83_17710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4Q83_17750	COG1309	transcriptional regulator
G4Q83_17770	COG4948	Mandelate Racemase Muconate Lactonizing
G4Q83_17775	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4Q83_17780	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_17795	COG0546	phosphoglycolate phosphatase activity
G4Q83_17810	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_17825	COG1024	Enoyl-CoA hydratase
G4Q83_17855	COG0710	3-dehydroquinate dehydratase activity
G4Q83_17865	COG3420	alginic acid biosynthetic process
G4Q83_17870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G4Q83_17900	COG0714	Associated with various cellular activities
G4Q83_17925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G4Q83_17930	COG2130	NADP-dependent
G4Q83_17945	COG1187	pseudouridine synthase activity
G4Q83_17960	COG1643	Atp-dependent helicase
G4Q83_17980	COG2050	protein possibly involved in aromatic compounds catabolism
G4Q83_17985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4Q83_17995	COG2062	phosphohistidine phosphatase, SixA
G4Q83_18000	COG1192	Involved in chromosome partitioning
G4Q83_18005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4Q83_18040	COG4221	oxidoreductase activity
G4Q83_18045	COG0583	DNA-binding transcription factor activity
G4Q83_18065	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_18085	COG3093	addiction module antidote protein HigA
G4Q83_18090	COG3549	Plasmid maintenance system killer
G4Q83_18095	COG1111	helicase
G4Q83_18095	COG1205	dead DEAH box helicase
G4Q83_18170	COG0339	signal peptide processing
G4Q83_18210	COG2911	Protein conserved in bacteria
G4Q83_18215	COG0729	surface antigen
G4Q83_18240	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4Q83_18245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G4Q83_18250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G4Q83_18255	COG3485	protocatechuate 3,4-dioxygenase
G4Q83_18260	COG3485	protocatechuate 3,4-dioxygenase
G4Q83_18270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G4Q83_18295	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_18305	COG2885	chlorophyll binding
G4Q83_18340	COG0501	Belongs to the peptidase M48B family
G4Q83_18345	COG1266	CAAX protease self-immunity
G4Q83_18350	COG0187	DNA topoisomerase II activity
G4Q83_18355	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G4Q83_18380	COG0706	membrane insertase activity
G4Q83_18395	COG0582	viral genome integration into host DNA
G4Q83_18405	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G4Q83_18415	COG0732	type I restriction modification DNA specificity domain
G4Q83_18420	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G4Q83_18485	COG3186	Phenylalanine-4-hydroxylase
G4Q83_18490	COG1522	sequence-specific DNA binding
G4Q83_18510	COG1752	Esterase of the alpha-beta hydrolase superfamily
G4Q83_18525	COG0671	phosphoesterase, PA-phosphatase related
G4Q83_18540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G4Q83_18565	COG1322	Protein conserved in bacteria
G4Q83_18570	COG2853	Lipoprotein
G4Q83_18585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G4Q83_18590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4Q83_18595	COG1127	ABC transporter
G4Q83_18605	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_18615	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G4Q83_18620	COG1074	ATP-dependent DNA helicase activity
G4Q83_18645	COG1119	ATPase activity
G4Q83_18665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G4Q83_18680	COG0753	catalase activity
G4Q83_18685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G4Q83_18690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4Q83_18715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4Q83_18760	COG1294	oxidase, subunit
G4Q83_18765	COG1271	oxidase subunit
G4Q83_18780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Q83_18785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G4Q83_18790	COG0408	coproporphyrinogen oxidase activity
G4Q83_18795	COG2323	membrane
G4Q83_18820	COG0589	response to stress
G4Q83_18840	COG0183	Belongs to the thiolase family
G4Q83_18875	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G4Q83_18880	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G4Q83_18910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G4Q83_18920	COG0612	Peptidase, M16
G4Q83_18930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4Q83_18935	COG3177	Filamentation induced by cAMP protein fic
G4Q83_18945	COG0596	Alpha beta hydrolase
G4Q83_18950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G4Q83_18960	COG0727	PFAM Uncharacterised protein family (UPF0153)
G4Q83_18975	COG0318	PFAM AMP-dependent synthetase and ligase
G4Q83_18980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4Q83_18990	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4Q83_19070	COG0671	phosphoesterase, PA-phosphatase related
G4Q83_19130	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G4Q83_19135	COG3791	Glutathione-dependent formaldehyde-activating
G4Q83_19185	COG0583	DNA-binding transcription factor activity
G4Q83_19205	COG0697	spore germination
G4Q83_19215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4Q83_19285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G4Q83_19290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4Q83_19295	COG1609	Transcriptional regulator
G4Q83_19305	COG2188	Transcriptional regulator
G4Q83_19325	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_19330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G4Q83_19365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G4Q83_19365	COG1565	acr, cog1565
G4Q83_19375	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
G4Q83_19425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G4Q83_19485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4Q83_19550	COG4807	Protein conserved in bacteria
G4Q83_19575	COG2203	Gaf domain
G4Q83_19575	COG3706	GGDEF domain
G4Q83_19575	COG4251	negative regulation of phosphorylation
G4Q83_19575	COG5001	Diguanylate cyclase
G4Q83_19610	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G4Q83_19635	COG2032	superoxide dismutase activity
G4Q83_19640	COG2032	superoxide dismutase activity
G4Q83_19670	COG2204	response regulator
G4Q83_19675	COG3852	Histidine kinase
G4Q83_19680	COG0004	ammonium transporteR
G4Q83_19685	COG0347	Belongs to the P(II) protein family
G4Q83_19690	COG0174	glutamine synthetase
G4Q83_19730	COG0251	oxidation-reduction process
G4Q83_19745	COG1414	Transcriptional regulator
G4Q83_19765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4Q83_19795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G4Q83_19815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4Q83_19820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G4Q83_19825	COG2201	protein-glutamate methylesterase activity
G4Q83_19830	COG2177	Part of the ABC transporter FtsEX involved in
G4Q83_19835	COG2884	Cell division ATP-binding protein ftsE
G4Q83_19845	COG3118	belongs to the thioredoxin family
G4Q83_19850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G4Q83_19870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4Q83_19920	COG1518	maintenance of DNA repeat elements
G4Q83_19925	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
G4Q83_19935	COG1652	LysM domain
G4Q83_19950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4Q83_19955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4Q83_19970	COG5383	Protein conserved in bacteria
G4Q83_20020	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G4Q83_20140	COG0180	Tryptophanyl-tRNA synthetase
G4Q83_20165	COG0697	spore germination
G4Q83_20195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G4Q83_20210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4Q83_20225	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_20260	COG1252	NADH dehydrogenase
G4Q83_20280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G4Q83_20290	COG0534	Mate efflux family protein
G4Q83_20295	COG0616	signal peptide processing
G4Q83_20310	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_20325	COG0009	L-threonylcarbamoyladenylate synthase
G4Q83_20330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4Q83_20330	COG1754	DNA topoisomerase type I activity
G4Q83_20335	COG1714	RDD family
G4Q83_20350	COG0758	DNA mediated transformation
G4Q83_20355	COG1652	LysM domain
G4Q83_20360	COG0242	peptide deformylase activity
G4Q83_20370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4Q83_20370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G4Q83_20375	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G4Q83_20390	COG0463	Glycosyl transferase, family 2
G4Q83_20410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4Q83_20440	COG0025	NhaP-type Na H and K H
G4Q83_20445	COG1131	(ABC) transporter
G4Q83_20450	COG0842	Transport permease protein
G4Q83_20465	COG1404	Belongs to the peptidase S8 family
G4Q83_20480	COG0745	RESPONSE REGULATOR receiver
G4Q83_20505	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G4Q83_20530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4Q83_20540	COG4953	penicillin-binding protein 1C
G4Q83_20570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4Q83_20580	COG0028	Belongs to the TPP enzyme family
G4Q83_20595	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G4Q83_20610	COG3385	transposase activity
G4Q83_20620	COG4948	Mandelate Racemase Muconate Lactonizing
G4Q83_20630	COG4771	TonB-dependent receptor
G4Q83_20670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G4Q83_20675	COG0366	Alpha amylase catalytic
G4Q83_20680	COG0366	Alpha amylase catalytic
G4Q83_20690	COG1609	Transcriptional regulator
G4Q83_20715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G4Q83_20735	COG4221	oxidoreductase activity
G4Q83_20745	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G4Q83_20770	COG1199	ATP-dependent helicase activity
G4Q83_20815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G4Q83_20825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4Q83_20835	COG0477	Major facilitator Superfamily
G4Q83_20840	COG0583	DNA-binding transcription factor activity
G4Q83_20845	COG0210	DNA helicase
G4Q83_20855	COG1289	transmembrane transporter activity
G4Q83_20860	COG2814	Major facilitator Superfamily
G4Q83_20895	COG2816	NAD+ diphosphatase activity
G4Q83_20940	COG1051	belongs to the nudix hydrolase family
G4Q83_20965	COG0708	Exodeoxyribonuclease III
G4Q83_20970	COG2814	Major facilitator Superfamily
G4Q83_20980	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G4Q83_20985	COG0739	heme binding
G4Q83_20990	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G4Q83_21110	COG2801	Transposase and inactivated derivatives
G4Q83_21125	COG0840	transmembrane signaling receptor activity
G4Q83_21130	COG3511	phospholipase C
G4Q83_21150	COG0745	RESPONSE REGULATOR receiver
G4Q83_21165	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G4Q83_21205	COG2814	Major facilitator Superfamily
G4Q83_21210	COG0583	DNA-binding transcription factor activity
G4Q83_21215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4Q83_21215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G4Q83_21225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4Q83_21235	COG2188	Transcriptional regulator
G4Q83_21295	COG2264	protein methyltransferase activity
G4Q83_21315	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G4Q83_21320	COG0138	bifunctional purine biosynthesis protein purh
G4Q83_21325	COG0151	Belongs to the GarS family
G4Q83_21335	COG0129	dihydroxy-acid dehydratase activity
G4Q83_21340	COG1028	Short-chain dehydrogenase reductase Sdr
G4Q83_21365	COG1012	belongs to the aldehyde dehydrogenase family
G4Q83_21370	COG1879	ABC-type sugar transport system periplasmic component
G4Q83_21375	COG1129	ABC transporter
G4Q83_21380	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Q83_21385	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Q83_21440	COG0702	epimerase
G4Q83_21445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Q83_21450	COG1285	pathogenesis
G4Q83_21465	COG2354	Protein conserved in bacteria
G4Q83_21485	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G4Q83_21490	COG1846	Transcriptional regulator
G4Q83_21495	COG1764	response to oxidative stress
G4Q83_21500	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4Q83_21505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4Q83_21525	COG0583	DNA-binding transcription factor activity
G4Q83_21530	COG2814	Major facilitator Superfamily
G4Q83_21550	COG0745	RESPONSE REGULATOR receiver
G4Q83_21560	COG1902	pentaerythritol trinitrate reductase activity
G4Q83_21605	COG0678	peroxiredoxin activity
G4Q83_21625	COG0604	alcohol dehydrogenase
G4Q83_21630	COG0330	HflC and HflK could
G4Q83_21635	COG0330	HflC and HflK could
G4Q83_21645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G4Q83_21700	COG0358	DNA primase activity
G4Q83_21705	COG1295	ribonuclease BN
G4Q83_21725	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G4Q83_21730	COG2308	Evidence 4 Homologs of previously reported genes of
G4Q83_21745	COG2133	pyrroloquinoline quinone binding
G4Q83_21755	COG0531	amino acid
G4Q83_21790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4Q83_21805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G4Q83_21810	COG0667	Aldo Keto reductase
G4Q83_21820	COG4771	TonB-dependent receptor
G4Q83_21865	COG2169	Transcriptional regulator
G4Q83_21865	COG1917	Cupin 2, conserved barrel domain protein
G4Q83_21875	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G4Q83_21880	COG4181	ATPase activity
G4Q83_21895	COG0642	Histidine kinase
G4Q83_21905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G4Q83_21910	COG0861	Integral membrane protein TerC family
G4Q83_21915	COG1704	LemA family
G4Q83_21945	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4Q83_21950	COG2967	ApaG domain
G4Q83_21955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G4Q83_21960	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G4Q83_21965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4Q83_21970	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G4Q83_21980	COG2096	Adenosyltransferase
G4Q83_21990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4Q83_21995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4Q83_22015	COG0697	spore germination
G4Q83_22025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4Q83_22035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G4Q83_22045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4Q83_22050	COG0583	DNA-binding transcription factor activity
G4Q83_22055	COG3634	alkyl hydroperoxide reductase activity
G4Q83_22065	COG2890	protein-(glutamine-N5) methyltransferase activity
G4Q83_22095	COG2826	transposase and inactivated derivatives, IS30 family
G4Q83_22130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4Q83_22130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4Q83_22165	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
G4Q83_22205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4Q83_22210	COG1404	Belongs to the peptidase S8 family
G4Q83_22215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G4Q83_22350	COG1475	DNA binding
G4Q83_22390	COG4962	Type ii secretion system protein e
G4Q83_22405	COG3451	type IV secretory pathway VirB4
G4Q83_22450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone