locus-tag	class	description
KM317_00010	COG0592	DNA-directed DNA polymerase activity
KM317_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KM317_00020	COG0187	DNA topoisomerase II activity
KM317_00025	COG1266	CAAX protease self-immunity
KM317_00030	COG0501	Belongs to the peptidase M48B family
KM317_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM317_00085	COG1280	lysine exporter protein (LysE YggA)
KM317_00100	COG4772	TonB-dependent receptor
KM317_00110	COG3284	Transcriptional regulator
KM317_00115	COG1012	belongs to the aldehyde dehydrogenase family
KM317_00155	COG1304	FMN binding
KM317_00160	COG2186	Transcriptional regulator
KM317_00180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM317_00260	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KM317_00285	COG4771	TonB-dependent receptor
KM317_00330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KM317_00345	COG3507	Belongs to the glycosyl hydrolase 43 family
KM317_00350	COG1609	Transcriptional regulator
KM317_00360	COG1028	Short-chain dehydrogenase reductase Sdr
KM317_00375	COG3186	Phenylalanine-4-hydroxylase
KM317_00380	COG1522	sequence-specific DNA binding
KM317_00395	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM317_00410	COG0671	phosphoesterase, PA-phosphatase related
KM317_00425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KM317_00460	COG1929	Belongs to the glycerate kinase type-1 family
KM317_00470	COG0531	amino acid
KM317_00475	COG4566	intracellular signal transduction
KM317_00480	COG4191	Histidine kinase
KM317_00485	COG1285	pathogenesis
KM317_00500	COG1322	Protein conserved in bacteria
KM317_00505	COG0386	Belongs to the glutathione peroxidase family
KM317_00515	COG2853	Lipoprotein
KM317_00530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KM317_00535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KM317_00540	COG1127	ABC transporter
KM317_00545	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KM317_00550	COG1074	ATP-dependent DNA helicase activity
KM317_00555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KM317_00575	COG0537	adenosine 5'-monophosphoramidase activity
KM317_00645	COG0477	Major facilitator Superfamily
KM317_00650	COG0302	gtp cyclohydrolase
KM317_00655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KM317_00685	COG0730	response to heat
KM317_00705	COG2951	lytic endotransglycosylase activity
KM317_00730	COG3135	benzoate transporter
KM317_00760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM317_00765	COG1803	Methylglyoxal synthase
KM317_00770	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KM317_00775	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KM317_00780	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KM317_00785	COG0493	'glutamate synthase
KM317_00790	COG0070	glutamate synthase
KM317_00790	COG0069	glutamate synthase activity
KM317_00790	COG0067	glutamate synthase
KM317_00835	COG1111	helicase
KM317_00835	COG1205	dead DEAH box helicase
KM317_00885	COG2271	Major facilitator Superfamily
KM317_00930	COG1192	Involved in chromosome partitioning
KM317_00935	COG2062	phosphohistidine phosphatase, SixA
KM317_00945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM317_00950	COG2050	protein possibly involved in aromatic compounds catabolism
KM317_00960	COG2267	carboxylic ester hydrolase activity
KM317_00975	COG1968	undecaprenyl-diphosphatase activity
KM317_00980	COG0174	glutamine synthetase
KM317_00985	COG0347	Belongs to the P(II) protein family
KM317_00990	COG0004	ammonium transporteR
KM317_00995	COG3852	Histidine kinase
KM317_01000	COG2204	response regulator
KM317_01005	COG2032	superoxide dismutase activity
KM317_01010	COG2032	superoxide dismutase activity
KM317_01020	COG0183	Belongs to the thiolase family
KM317_01060	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KM317_01065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KM317_01085	COG0702	epimerase
KM317_01090	COG0583	DNA-binding transcription factor activity
KM317_01115	COG0612	Peptidase, M16
KM317_01125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM317_01130	COG3177	Filamentation induced by cAMP protein fic
KM317_01145	COG0596	Alpha beta hydrolase
KM317_01155	COG0727	PFAM Uncharacterised protein family (UPF0153)
KM317_01160	COG0318	PFAM AMP-dependent synthetase and ligase
KM317_01175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM317_01185	COG1181	Belongs to the D-alanine--D-alanine ligase family
KM317_01205	COG4232	protein-disulfide reductase activity
KM317_01210	COG0564	pseudouridine synthase activity
KM317_01230	COG0339	signal peptide processing
KM317_01235	COG0681	Belongs to the peptidase S26 family
KM317_01255	COG0583	DNA-binding transcription factor activity
KM317_01260	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KM317_01265	COG2224	Isocitrate lyase
KM317_01270	COG3706	GGDEF domain
KM317_01300	COG0659	secondary active sulfate transmembrane transporter activity
KM317_01330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM317_01335	COG2130	NADP-dependent
KM317_01350	COG1187	pseudouridine synthase activity
KM317_01360	COG1643	Atp-dependent helicase
KM317_01365	COG0084	hydrolase, TatD family'
KM317_01455	COG0842	Transport permease protein
KM317_01460	COG1131	(ABC) transporter
KM317_01465	COG0543	2 iron, 2 sulfur cluster binding
KM317_01465	COG0633	Ferredoxin
KM317_01475	COG1476	TRANSCRIPTIONal
KM317_01485	COG4555	ABC transporter
KM317_01505	COG0625	glutathione transferase activity
KM317_01585	COG1199	ATP-dependent helicase activity
KM317_01650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM317_01665	COG0628	permease
KM317_01685	COG2133	pyrroloquinoline quinone binding
KM317_01735	COG5463	Belongs to the UPF0441 family
KM317_01740	COG0754	glutathionylspermidine amidase activity
KM317_01750	COG0714	Associated with various cellular activities
KM317_01785	COG1522	sequence-specific DNA binding
KM317_01805	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KM317_01820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM317_01825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM317_01850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KM317_01870	COG1028	Short-chain dehydrogenase reductase Sdr
KM317_01885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KM317_01895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM317_01910	COG0582	viral genome integration into host DNA
KM317_01965	COG0606	chelatase, subunit chli
KM317_01970	COG2960	long-chain fatty acid transporting porin activity
KM317_02000	COG1166	arginine decarboxylase activity
KM317_02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KM317_02010	COG1819	glycosyl
KM317_02015	COG2755	lipolytic protein G-D-S-L family
KM317_02015	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KM317_02020	COG0583	DNA-binding transcription factor activity
KM317_02040	COG4221	oxidoreductase activity
KM317_02060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM317_02080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KM317_02090	COG2814	Major facilitator Superfamily
KM317_02100	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KM317_02105	COG0739	heme binding
KM317_02110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KM317_02140	COG2885	chlorophyll binding
KM317_02145	COG1064	alcohol dehydrogenase
KM317_02150	COG2234	aminopeptidase activity
KM317_02160	COG4942	peptidase
KM317_02165	COG0793	Belongs to the peptidase S41A family
KM317_02200	COG0531	amino acid
KM317_02205	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KM317_02205	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KM317_02210	COG1486	melibiose metabolic process
KM317_02225	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KM317_02225	COG1565	acr, cog1565
KM317_02230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KM317_02235	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
KM317_02265	COG0109	protoheme IX farnesyltransferase activity
KM317_02280	COG0358	DNA primase activity
KM317_02285	COG1295	ribonuclease BN
KM317_02305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KM317_02325	COG2133	pyrroloquinoline quinone binding
KM317_02350	COG0531	amino acid
KM317_02360	COG4948	Mandelate Racemase Muconate Lactonizing
KM317_02370	COG4771	TonB-dependent receptor
KM317_02405	COG3501	Rhs element vgr protein
KM317_02405	COG3409	Peptidoglycan-binding domain 1 protein
KM317_02440	COG5383	Protein conserved in bacteria
KM317_02450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM317_02460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM317_02475	COG1652	LysM domain
KM317_02485	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KM317_02490	COG1518	maintenance of DNA repeat elements
KM317_02550	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KM317_02555	COG3118	belongs to the thioredoxin family
KM317_02565	COG2884	Cell division ATP-binding protein ftsE
KM317_02570	COG2177	Part of the ABC transporter FtsEX involved in
KM317_02575	COG2201	protein-glutamate methylesterase activity
KM317_02580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KM317_02585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM317_02590	COG2860	membrane
KM317_02605	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KM317_02615	COG0534	Mate efflux family protein
KM317_02620	COG0616	signal peptide processing
KM317_02630	COG1028	Short-chain dehydrogenase reductase Sdr
KM317_02645	COG0009	L-threonylcarbamoyladenylate synthase
KM317_02650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM317_02650	COG1754	DNA topoisomerase type I activity
KM317_02655	COG1714	RDD family
KM317_02675	COG0758	DNA mediated transformation
KM317_02680	COG1652	LysM domain
KM317_02685	COG0242	peptide deformylase activity
KM317_02690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KM317_02695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KM317_02695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KM317_02700	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KM317_02715	COG1215	transferase activity, transferring glycosyl groups
KM317_02735	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KM317_02750	COG1490	D-aminoacyl-tRNA deacylase activity
KM317_02755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM317_02770	COG1609	Transcriptional regulator
KM317_02785	COG0366	Alpha amylase catalytic
KM317_02790	COG0366	Alpha amylase catalytic
KM317_02805	COG0582	viral genome integration into host DNA
KM317_02810	COG0270	DNA (cytosine-5-)-methyltransferase activity
KM317_02840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KM317_02845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM317_02875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM317_02960	COG2003	Belongs to the UPF0758 family
KM317_02970	COG0484	heat shock protein binding
KM317_03040	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KM317_03105	COG1309	transcriptional regulator
KM317_03140	COG0840	transmembrane signaling receptor activity
KM317_03155	COG3546	catalase activity
KM317_03160	COG3685	Protein conserved in bacteria
KM317_03165	COG3685	Protein conserved in bacteria
KM317_03170	COG1028	Short-chain dehydrogenase reductase Sdr
KM317_03175	COG2205	protein histidine kinase activity
KM317_03185	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KM317_03200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KM317_03215	COG0028	Belongs to the TPP enzyme family
KM317_03220	COG4191	Histidine kinase
KM317_03225	COG2204	response regulator
KM317_03245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KM317_03245	COG1648	precorrin-2 dehydrogenase activity
KM317_03255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM317_03255	COG1116	anion transmembrane transporter activity
KM317_03260	COG2223	nitrite transmembrane transporter activity
KM317_03265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM317_03270	COG2146	nitrite reductase [NAD(P)H] activity
KM317_03275	COG0243	molybdopterin cofactor binding
KM317_03305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KM317_03315	COG0297	glycogen (starch) synthase activity
KM317_03325	COG2204	response regulator
KM317_03350	COG0181	hydroxymethylbilane synthase activity
KM317_03365	COG1733	regulation of RNA biosynthetic process
KM317_03380	COG1505	serine-type exopeptidase activity
KM317_03385	COG0436	Aminotransferase
KM317_03395	COG2832	Protein of unknown function (DUF454)
KM317_03405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KM317_03450	COG2226	methyltransferase
KM317_03475	COG0308	aminopeptidase N
KM317_03480	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM317_03480	COG0596	Alpha beta hydrolase
KM317_03505	COG2010	Cytochrome c
KM317_03515	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KM317_03525	COG3284	Transcriptional regulator
KM317_03530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM317_03535	COG1077	Cell shape determining protein MreB Mrl
KM317_03540	COG1792	Involved in formation and maintenance of cell shape
KM317_03550	COG0768	penicillin binding
KM317_03555	COG0772	Belongs to the SEDS family
KM317_03565	COG5434	Belongs to the glycosyl hydrolase 28 family
KM317_03570	COG2951	lytic endotransglycosylase activity
KM317_03580	COG1686	Belongs to the peptidase S11 family
KM317_03615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KM317_03640	COG1051	belongs to the nudix hydrolase family
KM317_03640	COG1056	cytidyltransferase-related domain
KM317_03670	COG1090	epimerase
KM317_03680	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KM317_03685	COG0673	inositol 2-dehydrogenase activity
KM317_03690	COG2823	Periplasmic or secreted lipoprotein
KM317_03700	COG2202	Pas domain
KM317_03700	COG2205	protein histidine kinase activity
KM317_03705	COG0784	Response regulator, receiver
KM317_03710	COG4191	Histidine kinase
KM317_03720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KM317_03725	COG1028	Short-chain dehydrogenase reductase Sdr
KM317_03740	COG4305	rare lipoprotein A
KM317_03755	COG3250	beta-galactosidase activity
KM317_03770	COG2188	Transcriptional regulator
KM317_03780	COG1609	Transcriptional regulator
KM317_03785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KM317_03790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KM317_03800	COG0617	tRNA 3'-terminal CCA addition
KM317_03830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KM317_03855	COG2207	Transcriptional regulator
KM317_03875	COG2205	protein histidine kinase activity
KM317_03895	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KM317_03900	COG3791	Glutathione-dependent formaldehyde-activating
KM317_03910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM317_03920	COG0697	spore germination
KM317_03930	COG1307	EDD domain protein, DegV family
KM317_03945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KM317_03970	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KM317_03995	COG0436	Aminotransferase
KM317_04030	COG1162	GTPase activity
KM317_04055	COG2211	Major facilitator Superfamily
KM317_04065	COG1028	Short-chain dehydrogenase reductase Sdr
KM317_04070	COG2851	Citrate transporter
KM317_04085	COG0642	Histidine kinase
KM317_04110	COG4191	Histidine kinase
KM317_04120	COG1301	dicarboxylic acid transport
KM317_04125	COG0280	phosphate acetyltransferase
KM317_04125	COG0281	malic enzyme
KM317_04150	COG1560	Kdo2-lipid A biosynthetic process
KM317_04155	COG1519	Transferase
KM317_04160	COG1538	Outer membrane efflux protein
KM317_04165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KM317_04175	COG3706	GGDEF domain
KM317_04180	COG0473	3-isopropylmalate dehydrogenase activity
KM317_04185	COG0066	3-isopropylmalate dehydratase activity
KM317_04205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KM317_04225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM317_04230	COG0840	transmembrane signaling receptor activity
KM317_04255	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KM317_04265	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KM317_04290	COG0563	adenylate kinase activity
KM317_04295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KM317_04320	COG0671	phosphoesterase, PA-phosphatase related
KM317_04335	COG1940	carbohydrate kinase activity
KM317_04345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM317_04505	COG0537	adenosine 5'-monophosphoramidase activity
KM317_04525	COG0714	Associated with various cellular activities
KM317_04550	COG1399	metal-binding, possibly nucleic acid-binding protein
KM317_04555	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KM317_04560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM317_04565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KM317_04570	COG1028	Short-chain dehydrogenase reductase Sdr
KM317_04575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM317_04585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KM317_04590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KM317_04595	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KM317_04630	COG4115	mRNA cleavage
KM317_04635	COG2161	toxin-antitoxin pair type II binding
KM317_04655	COG2010	Cytochrome c
KM317_04665	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
KM317_04675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KM317_04690	COG1773	rubredoxin
KM317_04705	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KM317_04715	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KM317_04740	COG3300	MHYT domain
KM317_04740	COG5001	Diguanylate cyclase
KM317_04745	COG3079	Belongs to the UPF0149 family
KM317_04750	COG0006	proline dipeptidase activity
KM317_04770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM317_04775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KM317_04780	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KM317_04785	COG1561	YicC-like family, N-terminal region
KM317_04790	COG0194	GDP metabolic process
KM317_04795	COG1758	RNA polymerase activity
KM317_04800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KM317_04835	COG0587	DNA-directed DNA polymerase activity
KM317_04850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KM317_04855	COG0372	Belongs to the citrate synthase family
KM317_04905	COG2373	Large extracellular alpha-helical protein
KM317_04920	COG4953	penicillin-binding protein 1C
KM317_04930	COG0678	peroxiredoxin activity
KM317_04950	COG0604	alcohol dehydrogenase
KM317_04955	COG0330	HflC and HflK could
KM317_04960	COG0330	HflC and HflK could
KM317_04970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KM317_05040	COG4804	nuclease activity
KM317_05045	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KM317_05070	COG3275	phosphorelay sensor kinase activity
KM317_05100	COG0492	ferredoxin-NADP+ reductase activity
KM317_05120	COG3459	Glycosyltransferase 36 associated
KM317_05130	COG1063	alcohol dehydrogenase
KM317_05155	COG0753	catalase activity
KM317_05160	COG2203	Gaf domain
KM317_05160	COG3706	GGDEF domain
KM317_05160	COG4251	negative regulation of phosphorylation
KM317_05160	COG5001	Diguanylate cyclase
KM317_05170	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KM317_05170	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KM317_05195	COG2814	Major facilitator Superfamily
KM317_05230	COG2194	sulfuric ester hydrolase activity
KM317_05240	COG0745	RESPONSE REGULATOR receiver
KM317_05245	COG2205	protein histidine kinase activity
KM317_05255	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KM317_05260	COG2894	cell division
KM317_05265	COG0850	regulation of cytokinetic process
KM317_05275	COG4585	Histidine kinase
KM317_05295	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM317_05305	COG1216	Glycosyl transferase, family 2
KM317_05310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM317_05320	COG1199	ATP-dependent helicase activity
KM317_05340	COG0189	ligase activity
KM317_05355	COG0835	chemotaxis
KM317_05360	COG0840	transmembrane signaling receptor activity
KM317_05365	COG0643	Histidine kinase
KM317_05365	COG0784	Response regulator, receiver
KM317_05365	COG2198	Histidine kinase
KM317_05370	COG2201	protein-glutamate methylesterase activity
KM317_05390	COG1446	asparaginase
KM317_05395	COG3142	Participates in the control of copper homeostasis
KM317_05485	COG3537	Alpha-1,2-mannosidase
KM317_05495	COG1472	Belongs to the glycosyl hydrolase 3 family
KM317_05505	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KM317_05510	COG3858	chitin binding
KM317_05510	COG1388	LysM domain
KM317_05525	COG0837	glucose binding
KM317_05535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KM317_05545	COG0494	nUDIX hydrolase
KM317_05550	COG1218	3'(2'),5'-bisphosphate nucleotidase
KM317_05555	COG3956	TIGRFAM MazG family protein
KM317_05560	COG1742	UPF0060 membrane protein
KM317_05565	COG0330	HflC and HflK could
KM317_05600	COG0697	spore germination
KM317_05625	COG2124	cytochrome p450
KM317_05630	COG2124	cytochrome p450
KM317_05635	COG2124	cytochrome p450
KM317_05640	COG1141	Ferredoxin
KM317_05645	COG1028	Short-chain dehydrogenase reductase Sdr
KM317_05650	COG2124	cytochrome p450
KM317_05655	COG0142	geranyltranstransferase activity
KM317_05660	COG1657	PFAM Prenyltransferase squalene oxidase
KM317_05670	COG1304	FMN binding
KM317_05685	COG1309	transcriptional regulator
KM317_05705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KM317_05710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM317_05715	COG0463	Glycosyl transferase, family 2
KM317_05720	COG0517	IMP dehydrogenase activity
KM317_05725	COG2982	Protein involved in outer membrane biogenesis
KM317_05730	COG1272	protein, Hemolysin III
KM317_05735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KM317_05740	COG0739	heme binding
KM317_05745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM317_05750	COG0626	cystathionine gamma-synthase activity
KM317_05755	COG0460	homoserine dehydrogenase
KM317_05755	COG0527	aspartate kinase activity
KM317_05760	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM317_05760	COG0596	Alpha beta hydrolase
KM317_05770	COG1760	l-serine dehydratase
KM317_05785	COG3038	cytochrome b561
KM317_05805	COG2814	Major facilitator Superfamily
KM317_05810	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KM317_05820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM317_05900	COG0519	Catalyzes the synthesis of GMP from XMP
KM317_05915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KM317_05940	COG0840	transmembrane signaling receptor activity
KM317_05950	COG1113	amino acid transport
KM317_05975	COG2239	Acts as a magnesium transporter
KM317_05980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KM317_05985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM317_05995	COG1660	Displays ATPase and GTPase activities
KM317_06005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM317_06020	COG1137	ATPase activity
KM317_06035	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KM317_06080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KM317_06105	COG0628	permease
KM317_06115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KM317_06120	COG3178	'Phosphotransferase
KM317_06135	COG1555	photosystem II stabilization
KM317_06155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KM317_06160	COG1477	protein flavinylation
KM317_06185	COG4774	siderophore transport
KM317_06190	COG2146	nitrite reductase [NAD(P)H] activity
KM317_06200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KM317_06205	COG0719	Fe-S assembly protein
KM317_06210	COG0396	ATPase activity
KM317_06215	COG0719	Fe-S assembly protein
KM317_06230	COG0693	protein deglycase activity
KM317_06245	COG0739	heme binding
KM317_06260	COG1764	response to oxidative stress
KM317_06270	COG0384	phenazine biosynthesis protein PhzF
KM317_06275	COG0527	aspartate kinase activity
KM317_06290	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KM317_06300	COG0142	geranyltranstransferase activity
KM317_06305	COG0629	single-stranded DNA binding
KM317_06310	COG3550	peptidyl-serine autophosphorylation
KM317_06325	COG3104	oligopeptide transport
KM317_06330	COG1297	OPT oligopeptide transporter protein
KM317_06335	COG0823	Involved in the tonB-independent uptake of proteins
KM317_06335	COG1506	peptidase
KM317_06355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KM317_06360	COG2879	small protein
KM317_06365	COG1966	Carbon starvation protein
KM317_06390	COG1515	deoxyribonuclease V activity
KM317_06410	COG2211	Major facilitator Superfamily
KM317_06435	COG5001	Diguanylate cyclase
KM317_06435	COG2203	Gaf domain
KM317_06435	COG4251	negative regulation of phosphorylation
KM317_06435	COG3706	GGDEF domain
KM317_06440	COG0835	chemotaxis
KM317_06445	COG0840	transmembrane signaling receptor activity
KM317_06450	COG0840	transmembrane signaling receptor activity
KM317_06455	COG0840	transmembrane signaling receptor activity
KM317_06460	COG0643	Histidine kinase
KM317_06460	COG2198	Histidine kinase
KM317_06470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KM317_06490	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KM317_06510	COG4452	Inner membrane protein CreD
KM317_06535	COG0735	belongs to the Fur family
KM317_06545	COG0667	Aldo Keto reductase
KM317_06670	COG1187	pseudouridine synthase activity
KM317_06695	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KM317_06720	COG1132	(ABC) transporter
KM317_06740	COG0583	DNA-binding transcription factor activity
KM317_06785	COG1981	membrane
KM317_06795	COG0825	malonyl-CoA metabolic process
KM317_06810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KM317_06815	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KM317_06825	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KM317_06830	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KM317_06835	COG0750	zinc metalloprotease
KM317_06840	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KM317_06845	COG0575	Belongs to the CDS family
KM317_06850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KM317_06860	COG0528	UMP kinase activity
KM317_06870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KM317_06910	COG0024	Methionine aminopeptidase
KM317_06925	COG1393	Belongs to the ArsC family
KM317_06930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM317_06940	COG0367	asparagine synthase
KM317_06985	COG1566	PFAM secretion protein HlyD family protein
KM317_06990	COG2814	Major facilitator Superfamily
KM317_07025	COG0557	exoribonuclease II activity
KM317_07035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM317_07060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KM317_07080	COG0704	Plays a role in the regulation of phosphate uptake
KM317_07090	COG0581	inorganic phosphate transmembrane transporter activity
KM317_07095	COG0573	inorganic phosphate transmembrane transporter activity
KM317_07100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM317_07105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM317_07125	COG0659	secondary active sulfate transmembrane transporter activity
KM317_07130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KM317_07140	COG1024	Enoyl-CoA hydratase
KM317_07200	COG5002	protein histidine kinase activity
KM317_07200	COG0784	Response regulator, receiver
KM317_07200	COG2205	protein histidine kinase activity
KM317_07205	COG2733	membrane
KM317_07225	COG0686	Belongs to the AlaDH PNT family
KM317_07230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM317_07235	COG1396	sequence-specific DNA binding
KM317_07235	COG1917	Cupin 2, conserved barrel domain protein
KM317_07240	COG1012	belongs to the aldehyde dehydrogenase family
KM317_07260	COG2223	nitrite transmembrane transporter activity
KM317_07270	COG0243	molybdopterin cofactor binding
KM317_07290	COG0477	Major facilitator Superfamily
KM317_07295	COG3706	GGDEF domain
KM317_07300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM317_07305	COG0174	glutamine synthetase
KM317_07310	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KM317_07315	COG0174	glutamine synthetase
KM317_07325	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KM317_07330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KM317_07350	COG3842	ATPase activity
KM317_07355	COG1176	ABC-type spermidine putrescine transport system, permease component I
KM317_07360	COG1177	transmembrane transport
KM317_07365	COG1012	belongs to the aldehyde dehydrogenase family
KM317_07380	COG4535	Mg2 and Co2 transporter CorC
KM317_07395	COG1702	phosphate starvation-inducible protein PhoH
KM317_07405	COG0625	glutathione transferase activity
KM317_07410	COG0741	lytic transglycosylase activity
KM317_07415	COG0723	plastoquinol--plastocyanin reductase activity
KM317_07420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KM317_07430	COG2857	Cytochrome c1
KM317_07435	COG0625	glutathione transferase activity
KM317_07440	COG2969	positive regulation of protein catabolic process
KM317_07480	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KM317_07485	COG1028	Short-chain dehydrogenase reductase Sdr
KM317_07490	COG2095	MarC family integral membrane protein
KM317_07500	COG1611	Belongs to the LOG family
KM317_07505	COG3275	phosphorelay sensor kinase activity
KM317_07550	COG0556	nucleotide-excision repair
KM317_07565	COG3505	Type IV secretory pathway VirD4
KM317_07585	COG2948	multi-organism process
KM317_07650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KM317_07660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KM317_07665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KM317_07715	COG0438	transferase activity, transferring glycosyl groups
KM317_07720	COG0438	transferase activity, transferring glycosyl groups
KM317_07750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KM317_07760	COG1960	acyl-CoA dehydrogenase activity
KM317_07800	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KM317_07805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KM317_07805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KM317_07810	COG0802	atpase or kinase
KM317_07815	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM317_07820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KM317_07840	COG1028	Short-chain dehydrogenase reductase Sdr
KM317_07870	COG2081	HI0933 family
KM317_07875	COG4681	YaeQ
KM317_07880	COG0564	pseudouridine synthase activity
KM317_07890	COG0625	glutathione transferase activity
KM317_07895	COG0657	acetylesterase activity
KM317_07900	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KM317_07925	COG0513	Belongs to the DEAD box helicase family
KM317_07930	COG0488	(ABC) transporter
KM317_07945	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM317_07955	COG1472	Belongs to the glycosyl hydrolase 3 family
KM317_08000	COG1846	Transcriptional regulator
KM317_08005	COG0339	signal peptide processing
KM317_08015	COG0386	Belongs to the glutathione peroxidase family
KM317_08085	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KM317_08090	COG0084	hydrolase, TatD family'
KM317_08105	COG1960	acyl-CoA dehydrogenase activity
KM317_08115	COG0305	Participates in initiation and elongation during chromosome replication
KM317_08145	COG0582	viral genome integration into host DNA
KM317_08150	COG0583	DNA-binding transcription factor activity
KM317_08225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM317_08235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM317_08240	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
KM317_08250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM317_08295	COG0583	DNA-binding transcription factor activity
KM317_08315	COG0352	thiamine-phosphate diphosphorylase activity
KM317_08315	COG0351	phosphomethylpyrimidine kinase
KM317_08330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KM317_08335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KM317_08345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KM317_08355	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KM317_08360	COG3734	2-keto-3-deoxy-galactonokinase
KM317_08375	COG0800	Aldolase
KM317_08395	COG1501	Belongs to the glycosyl hydrolase 31 family
KM317_08405	COG1070	Carbohydrate kinase
KM317_08410	COG2115	Belongs to the xylose isomerase family
KM317_08415	COG0477	Major facilitator Superfamily
KM317_08420	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM317_08440	COG0617	tRNA 3'-terminal CCA addition
KM317_08450	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KM317_08465	COG0166	Belongs to the GPI family
KM317_08485	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
KM317_08500	COG0671	phosphoesterase, PA-phosphatase related
KM317_08530	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM317_08535	COG0167	dihydroorotate dehydrogenase activity
KM317_08550	COG1012	belongs to the aldehyde dehydrogenase family
KM317_08565	COG0460	homoserine dehydrogenase
KM317_08565	COG0527	aspartate kinase activity
KM317_08570	COG0083	homoserine kinase activity
KM317_08575	COG2951	lytic endotransglycosylase activity
KM317_08585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KM317_08595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM317_08600	COG0124	histidyl-tRNA synthetase
KM317_08610	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KM317_08615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KM317_08620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM317_08630	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KM317_08645	COG0140	phosphoribosyl-ATP diphosphatase activity
KM317_08645	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KM317_08660	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
KM317_08665	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KM317_08670	COG0235	Class ii aldolase
KM317_08675	COG0531	amino acid
KM317_08680	COG0531	amino acid
KM317_08695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KM317_08700	COG0277	FAD linked oxidase domain protein
KM317_08720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KM317_08740	COG1024	Enoyl-CoA hydratase
KM317_08770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM317_08775	COG2258	MOSC domain
KM317_08785	COG0505	Belongs to the CarA family
KM317_08795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KM317_08800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KM317_08815	COG4676	Protein conserved in bacteria
KM317_08840	COG2198	Histidine kinase
KM317_08840	COG0784	Response regulator, receiver
KM317_08840	COG2205	protein histidine kinase activity
KM317_08845	COG1024	Enoyl-CoA hydratase
KM317_08850	COG0318	PFAM AMP-dependent synthetase and ligase
KM317_08915	COG0840	transmembrane signaling receptor activity
KM317_08925	COG0840	transmembrane signaling receptor activity
KM317_08935	COG0835	chemotaxis
KM317_08945	COG0840	transmembrane signaling receptor activity
KM317_08955	COG0840	transmembrane signaling receptor activity
KM317_08960	COG0840	transmembrane signaling receptor activity
KM317_08965	COG0840	transmembrane signaling receptor activity
KM317_08975	COG0840	transmembrane signaling receptor activity
KM317_08980	COG0840	transmembrane signaling receptor activity
KM317_08985	COG0840	transmembrane signaling receptor activity
KM317_08990	COG0840	transmembrane signaling receptor activity
KM317_09005	COG0745	RESPONSE REGULATOR receiver
KM317_09020	COG1192	Involved in chromosome partitioning
KM317_09030	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM317_09035	COG2198	Histidine kinase
KM317_09035	COG0784	Response regulator, receiver
KM317_09035	COG0643	Histidine kinase
KM317_09040	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
KM317_09090	COG1684	flagellar biosynthetic protein fliR
KM317_09095	COG1987	bacterial-type flagellum assembly
KM317_09105	COG3190	flagellar
KM317_09155	COG1677	Flagellar hook-basal body complex protein FliE
KM317_09180	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KM317_09215	COG1028	Short-chain dehydrogenase reductase Sdr
KM317_09220	COG1028	Short-chain dehydrogenase reductase Sdr
KM317_09225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM317_09245	COG2201	protein-glutamate methylesterase activity
KM317_09250	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KM317_09255	COG2197	response regulator
KM317_09275	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KM317_09280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KM317_09285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KM317_09290	COG1256	bacterial-type flagellum assembly
KM317_09290	COG4786	Flagellar basal body rod
KM317_09305	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KM317_09320	COG1749	Flagellar hook protein flgE
KM317_09330	COG1558	bacterial-type flagellum-dependent cell motility
KM317_09340	COG0784	Response regulator, receiver
KM317_09340	COG0835	chemotaxis
KM317_09385	COG1116	anion transmembrane transporter activity
KM317_09405	COG2915	High frequency lysogenization protein hflD homolog
KM317_09410	COG0482	sulfurtransferase activity
KM317_09430	COG0542	response to heat
KM317_09440	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KM317_09450	COG0492	ferredoxin-NADP+ reductase activity
KM317_09455	COG1674	ftsk spoiiie
KM317_09475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KM317_09480	COG0038	chloride channel
KM317_09525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM317_09560	COG1595	DNA-templated transcription, initiation
KM317_09580	COG3038	cytochrome b561
KM317_09610	COG2244	polysaccharide biosynthetic process
KM317_09650	COG0297	glycogen (starch) synthase activity
KM317_09655	COG0438	transferase activity, transferring glycosyl groups
KM317_09675	COG1132	(ABC) transporter
KM317_09685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM317_09690	COG1304	FMN binding
KM317_09700	COG0346	lactoylglutathione lyase activity
KM317_09745	COG1024	Enoyl-CoA hydratase
KM317_09750	COG1024	Enoyl-CoA hydratase
KM317_09760	COG1024	Enoyl-CoA hydratase
KM317_09775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KM317_09780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KM317_09840	COG1136	(ABC) transporter
KM317_09840	COG0577	efflux transmembrane transporter activity
KM317_09870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM317_09870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM317_09875	COG1105	Belongs to the carbohydrate kinase PfkB family
KM317_09880	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM317_09880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KM317_09885	COG1609	Transcriptional regulator
KM317_09900	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KM317_09905	COG0069	glutamate synthase activity
KM317_09945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM317_09960	COG1253	flavin adenine dinucleotide binding
KM317_09970	COG0306	phosphate transporter
KM317_09990	COG0504	CTP synthase activity
KM317_09995	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KM317_10005	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KM317_10010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KM317_10015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KM317_10030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KM317_10040	COG1238	metal cluster binding
KM317_10055	COG1534	Rna-binding protein
KM317_10060	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KM317_10065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM317_10070	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KM317_10075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KM317_10085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KM317_10090	COG1546	Belongs to the CinA family
KM317_10095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KM317_10100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KM317_10105	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KM317_10115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM317_10150	COG4191	Histidine kinase
KM317_10150	COG0784	Response regulator, receiver
KM317_10155	COG2204	response regulator
KM317_10160	COG2204	response regulator
KM317_10165	COG0415	Belongs to the DNA photolyase family
KM317_10180	COG0583	DNA-binding transcription factor activity
KM317_10195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM317_10240	COG1404	Belongs to the peptidase S8 family
KM317_10245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KM317_10250	COG2867	negative regulation of translational initiation
KM317_10260	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KM317_10265	COG0735	belongs to the Fur family
KM317_10270	COG0497	DNA recombination
KM317_10275	COG1420	regulation of RNA biosynthetic process
KM317_10280	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KM317_10285	COG0443	Heat shock 70 kDa protein
KM317_10290	COG0484	heat shock protein binding
KM317_10295	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
KM317_10300	COG0287	Prephenate dehydrogenase
KM317_10300	COG1605	Chorismate mutase
KM317_10315	COG1132	(ABC) transporter
KM317_10360	COG0567	Dehydrogenase, E1 component
KM317_10370	COG2850	peptidyl-arginine hydroxylation
KM317_10380	COG2885	chlorophyll binding
KM317_10430	COG1131	(ABC) transporter
KM317_10435	COG1725	Transcriptional regulator
KM317_10445	COG0386	Belongs to the glutathione peroxidase family
KM317_10460	COG2900	Belongs to the SlyX family
KM317_10470	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KM317_10470	COG2755	lipolytic protein G-D-S-L family
KM317_10480	COG1410	methionine synthase
KM317_10480	COG0646	methionine synthase
KM317_10485	COG0646	methionine synthase
KM317_10485	COG1410	methionine synthase
KM317_10490	COG2226	methyltransferase
KM317_10495	COG1960	acyl-CoA dehydrogenase activity
KM317_10500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM317_10505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM317_10520	COG2902	Dehydrogenase
KM317_10550	COG2925	Exonuclease
KM317_10560	COG3844	kynureninase activity
KM317_10565	COG1289	transmembrane transporter activity
KM317_10575	COG0288	reversible hydration of carbon dioxide
KM317_10620	COG2197	response regulator
KM317_10645	COG0316	Belongs to the HesB IscA family
KM317_10650	COG2977	Belongs to the P-Pant transferase superfamily
KM317_10680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM317_10685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KM317_10690	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KM317_10700	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KM317_10725	COG1309	transcriptional regulator
KM317_10745	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KM317_10765	COG1228	amidohydrolase
KM317_10780	COG4221	oxidoreductase activity
KM317_10820	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KM317_10825	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KM317_10830	COG0077	Prephenate dehydratase
KM317_10830	COG1605	Chorismate mutase
KM317_10880	COG1530	ribonuclease E activity
KM317_10895	COG0428	transporter
KM317_10910	COG0316	Belongs to the HesB IscA family
KM317_10910	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KM317_10930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM317_10950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KM317_10955	COG2957	Belongs to the agmatine deiminase family
KM317_10965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KM317_10970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KM317_10975	COG0539	negative regulation of cytoplasmic translation
KM317_10980	COG0776	regulation of translation
KM317_10990	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KM317_10995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KM317_11005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM317_11010	COG0183	Belongs to the thiolase family
KM317_11015	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM317_11015	COG1024	Enoyl-CoA hydratase
KM317_11030	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KM317_11040	COG1426	Protein conserved in bacteria
KM317_11050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KM317_11060	COG0746	molybdenum cofactor guanylyltransferase activity
KM317_11070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM317_11075	COG0475	glutathione-regulated potassium exporter activity
KM317_11075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM317_11090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KM317_11145	COG1649	PFAM Uncharacterised BCR, COG1649
KM317_11175	COG5002	protein histidine kinase activity
KM317_11175	COG5000	phosphorelay sensor kinase activity
KM317_11235	COG0784	Response regulator, receiver
KM317_11235	COG2205	protein histidine kinase activity
KM317_11240	COG2183	response to ionizing radiation
KM317_11245	COG4191	Histidine kinase
KM317_11245	COG0784	Response regulator, receiver
KM317_11275	COG3243	poly(R)-hydroxyalkanoic acid synthase
KM317_11285	COG1183	phosphatidylcholine synthase activity
KM317_11290	COG1028	Short-chain dehydrogenase reductase Sdr
KM317_11305	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KM317_11315	COG0668	transmembrane transport
KM317_11320	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KM317_11335	COG1914	H( )-stimulated, divalent metal cation uptake system
KM317_11345	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KM317_11350	COG1501	Belongs to the glycosyl hydrolase 31 family
KM317_11355	COG2207	Transcriptional regulator
KM317_11365	COG1538	Outer membrane efflux protein
KM317_11375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM317_11400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KM317_11415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KM317_11425	COG1663	tetraacyldisaccharide 4'-kinase activity
KM317_11430	COG1132	(ABC) transporter
KM317_11435	COG0848	biopolymer transport protein
KM317_11440	COG0811	peptide transport
KM317_11465	COG1136	(ABC) transporter
KM317_11470	COG4591	ABC-type transport system involved in lipoprotein release permease component
KM317_11480	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KM317_11495	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KM317_11500	COG2009	succinate dehydrogenase
KM317_11510	COG0354	folic acid binding
KM317_11515	COG3842	ATPase activity
KM317_11520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM317_11535	COG0129	dihydroxy-acid dehydratase activity
KM317_11540	COG0800	Aldolase
KM317_11550	COG0395	ABC-type sugar transport system, permease component
KM317_11585	COG2350	Protein conserved in bacteria
KM317_11590	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KM317_11595	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KM317_11600	COG1187	pseudouridine synthase activity
KM317_11635	COG0436	Aminotransferase
KM317_11640	COG4133	protoheme IX ABC transporter activity
KM317_11685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM317_11690	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KM317_11695	COG4988	ABC transporter
KM317_11705	COG1294	oxidase, subunit
KM317_11730	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KM317_11750	COG0165	Argininosuccinate lyase
KM317_11755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KM317_11765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KM317_11770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM317_11780	COG0137	argininosuccinate synthase activity
KM317_11785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KM317_11800	COG2166	iron-sulfur cluster assembly
KM317_11805	COG2814	Major facilitator Superfamily
KM317_11855	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KM317_11865	COG4677	pectinesterase activity
KM317_11875	COG4677	pectinesterase activity
KM317_11895	COG0402	S-adenosylhomocysteine deaminase activity
KM317_11900	COG3548	integral membrane protein
KM317_11910	COG1509	lysine 2,3-aminomutase activity
KM317_11940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM317_11945	COG1862	Preprotein translocase
KM317_11955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KM317_11965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM317_11980	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KM317_11985	COG3291	Pkd domain containing protein
KM317_11990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM317_12020	COG0644	oxidoreductase
KM317_12040	COG0405	Gamma-glutamyltransferase
KM317_12045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KM317_12060	COG0742	ribosomal rna small subunit methyltransferase
KM317_12085	COG4771	TonB-dependent receptor
KM317_12095	COG3507	Belongs to the glycosyl hydrolase 43 family
KM317_12130	COG0531	amino acid
KM317_12145	COG0006	proline dipeptidase activity
KM317_12155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KM317_12170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM317_12175	COG3938	Belongs to the proline racemase family
KM317_12185	COG0552	protein localization to endoplasmic reticulum
KM317_12190	COG1194	a g-specific adenine glycosylase
KM317_12230	COG0582	viral genome integration into host DNA
KM317_12255	COG0835	chemotaxis
KM317_12260	COG0840	transmembrane signaling receptor activity
KM317_12265	COG0840	transmembrane signaling receptor activity
KM317_12270	COG1201	RNA secondary structure unwinding
KM317_12280	COG5001	Diguanylate cyclase
KM317_12280	COG3300	MHYT domain
KM317_12285	COG1185	polyribonucleotide nucleotidyltransferase activity
KM317_12295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KM317_12310	COG0195	Participates in both transcription termination and antitermination
KM317_12325	COG1007	ATP synthesis coupled electron transport
KM317_12360	COG1034	ATP synthesis coupled electron transport
KM317_12365	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KM317_12370	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KM317_12375	COG0649	NAD binding
KM317_12380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM317_12390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM317_12420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KM317_12450	COG3853	Toxic anion resistance protein (TelA)
KM317_12485	COG2890	protein-(glutamine-N5) methyltransferase activity
KM317_12495	COG0688	phosphatidylethanolamine metabolic process
KM317_12510	COG0741	lytic transglycosylase activity
KM317_12515	COG0433	COG0433 Predicted ATPase
KM317_12530	COG0189	ligase activity
KM317_12545	COG0494	nUDIX hydrolase
KM317_12560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KM317_12580	COG1714	RDD family
KM317_12585	COG0717	Belongs to the dCTP deaminase family
KM317_12590	COG0489	protein tyrosine kinase activity
KM317_12595	COG4771	TonB-dependent receptor
KM317_12600	COG4771	TonB-dependent receptor
KM317_12605	COG0457	Tetratricopeptide repeat
KM317_12620	COG3590	peptidase
KM317_12655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM317_12660	COG2311	Membrane
KM317_12665	COG1047	Peptidyl-prolyl cis-trans
KM317_12670	COG0791	NLP P60 protein
KM317_12675	COG0791	NLP P60 protein
KM317_12680	COG1607	acyl-coa hydrolase
KM317_12690	COG1301	dicarboxylic acid transport
KM317_12695	COG1785	Belongs to the alkaline phosphatase family
KM317_12710	COG1722	exodeoxyribonuclease VII activity
KM317_12715	COG0142	geranyltranstransferase activity
KM317_12725	COG4104	PAAR repeat-containing protein
KM317_12740	COG0312	modulator of DNA gyrase
KM317_12750	COG0312	modulator of DNA gyrase
KM317_12770	COG2968	Membrane
KM317_12785	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KM317_12800	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KM317_12815	COG0495	leucyl-tRNA aminoacylation
KM317_12825	COG3118	belongs to the thioredoxin family
KM317_12840	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KM317_12850	COG2040	homocysteine
KM317_12860	COG0346	lactoylglutathione lyase activity
KM317_12900	COG2878	Part of a membrane complex involved in electron transport
KM317_12915	COG1595	DNA-templated transcription, initiation
KM317_12940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KM317_12960	COG0251	oxidation-reduction process
KM317_12970	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KM317_12970	COG0392	lysyltransferase activity
KM317_13000	COG2814	Major facilitator Superfamily
KM317_13005	COG1902	pentaerythritol trinitrate reductase activity
KM317_13015	COG0583	DNA-binding transcription factor activity
KM317_13030	COG2824	Alkylphosphonate utilization operon protein PhnA
KM317_13035	COG1047	Peptidyl-prolyl cis-trans
KM317_13040	COG1077	Cell shape determining protein MreB Mrl
KM317_13075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KM317_13090	COG1451	nucleotide metabolic process
KM317_13120	COG2186	Transcriptional regulator
KM317_13125	COG3250	beta-galactosidase activity
KM317_13170	COG1703	isobutyryl-CoA mutase activity
KM317_13170	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KM317_13170	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KM317_13195	COG0183	Belongs to the thiolase family
KM317_13205	COG0443	Heat shock 70 kDa protein
KM317_13235	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KM317_13235	COG1793	dna ligase
KM317_13240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KM317_13240	COG1793	dna ligase
KM317_13245	COG1201	RNA secondary structure unwinding
KM317_13255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM317_13260	COG1278	Cold shock
KM317_13265	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KM317_13270	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KM317_13275	COG1472	Belongs to the glycosyl hydrolase 3 family
KM317_13280	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM317_13285	COG2954	triphosphatase activity
KM317_13295	COG2204	response regulator
KM317_13300	COG1381	Involved in DNA repair and RecF pathway recombination
KM317_13305	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KM317_13320	COG0681	Belongs to the peptidase S26 family
KM317_13325	COG0481	GTPase activity
KM317_13330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM317_13345	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM317_13345	COG1024	Enoyl-CoA hydratase
KM317_13365	COG2855	membrane
KM317_13375	COG0577	efflux transmembrane transporter activity
KM317_13375	COG1136	(ABC) transporter
KM317_13380	COG0577	efflux transmembrane transporter activity
KM317_13380	COG1136	(ABC) transporter
KM317_13445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KM317_13475	COG0534	Mate efflux family protein
KM317_13480	COG0335	large ribosomal subunit rRNA binding
KM317_13490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KM317_13495	COG0228	four-way junction DNA binding
KM317_13505	COG2070	2-Nitropropane dioxygenase
KM317_13510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KM317_13535	COG0475	glutathione-regulated potassium exporter activity
KM317_13545	COG0625	glutathione transferase activity
KM317_13550	COG1082	Xylose isomerase domain protein TIM barrel
KM317_13560	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM317_13565	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM317_13570	COG1129	ABC transporter
KM317_13575	COG1879	ABC-type sugar transport system periplasmic component
KM317_13580	COG1012	belongs to the aldehyde dehydrogenase family
KM317_13600	COG0129	dihydroxy-acid dehydratase activity
KM317_13625	COG2207	Transcriptional regulator
KM317_13645	COG1317	bacterial-type flagellum organization
KM317_13670	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM317_13695	COG4794	Type iii secretion
KM317_13730	COG0745	RESPONSE REGULATOR receiver
KM317_13780	COG3152	Membrane
KM317_13790	COG0156	8-amino-7-oxononanoate synthase activity
KM317_13800	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KM317_13805	COG1845	cytochrome c oxidase, subunit III
KM317_13810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KM317_13840	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KM317_13855	COG0196	riboflavin kinase activity
KM317_13860	COG0728	peptidoglycan biosynthetic process
KM317_13875	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KM317_13880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KM317_13885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM317_13890	COG0824	Thioesterase
KM317_13900	COG1024	Enoyl-CoA hydratase
KM317_13905	COG1946	Acyl-CoA thioesterase
KM317_13960	COG1073	alpha beta
KM317_13985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KM317_14030	COG1643	Atp-dependent helicase
KM317_14035	COG0783	Belongs to the Dps family
KM317_14045	COG0514	ATP-dependent DNA helicase (RecQ)
KM317_14065	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KM317_14070	COG0602	queuosine metabolic process
KM317_14080	COG2885	chlorophyll binding
KM317_14095	COG0848	biopolymer transport protein
KM317_14105	COG0824	Thioesterase
KM317_14110	COG2255	four-way junction helicase activity
KM317_14115	COG3158	transport of potassium into the cell
KM317_14120	COG0632	four-way junction helicase activity
KM317_14130	COG0217	transcriptional regulatory protein
KM317_14180	COG0657	acetylesterase activity
KM317_14180	COG2755	lipolytic protein G-D-S-L family
KM317_14205	COG0488	(ABC) transporter
KM317_14255	COG4651	solute:proton antiporter activity
KM317_14255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM317_14265	COG4772	TonB-dependent receptor
KM317_14275	COG4264	IucA IucC family
KM317_14280	COG2814	Major facilitator Superfamily
KM317_14285	COG4264	IucA IucC family
KM317_14290	COG0019	diaminopimelate decarboxylase activity
KM317_14315	COG0542	response to heat
KM317_14340	COG0454	-acetyltransferase
KM317_14365	COG3387	PFAM Glycoside hydrolase 15-related
KM317_14380	COG4993	Dehydrogenase
KM317_14385	COG0840	transmembrane signaling receptor activity
KM317_14395	COG0564	pseudouridine synthase activity
KM317_14400	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KM317_14410	COG1125	glycine betaine transport
KM317_14415	COG1174	glycine betaine transport
KM317_14430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KM317_14440	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KM317_14440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KM317_14470	COG3657	addiction module killer protein
KM317_14475	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KM317_14500	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KM317_14515	COG0745	RESPONSE REGULATOR receiver
KM317_14525	COG0189	ligase activity
KM317_14535	COG3511	phospholipase C
KM317_14555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KM317_14605	COG2022	thiamine diphosphate biosynthetic process
KM317_14615	COG0471	metal ion transport
KM317_14615	COG3273	potassium ion transport
KM317_14630	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM317_14645	COG1609	Transcriptional regulator
KM317_14655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM317_14665	COG1115	amino acid carrier protein
KM317_14690	COG0438	transferase activity, transferring glycosyl groups
KM317_14695	COG0840	transmembrane signaling receptor activity
KM317_14700	COG0529	Catalyzes the synthesis of activated sulfate
KM317_14700	COG2895	sulfate adenylyltransferase (ATP) activity
KM317_14710	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KM317_14715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM317_14720	COG0175	sulfate reduction
KM317_14750	COG1393	Belongs to the ArsC family
KM317_14755	COG0784	Response regulator, receiver
KM317_14755	COG2198	Histidine kinase
KM317_14755	COG2205	protein histidine kinase activity
KM317_14775	COG1648	precorrin-2 dehydrogenase activity
KM317_14775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KM317_14805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KM317_14815	COG2351	hydroxyisourate hydrolase activity
KM317_14820	COG2072	flavoprotein involved in K transport
KM317_14840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KM317_14885	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KM317_14890	COG3588	fructose-bisphosphate aldolase
KM317_14895	COG0469	pyruvate kinase activity
KM317_14940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM317_14945	COG3047	cAMP biosynthetic process
KM317_14965	COG0640	Transcriptional regulator
KM317_14975	COG0725	ABC transporter, periplasmic molybdate-binding protein
KM317_14980	COG4149	molybdate abc transporter
KM317_14985	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KM317_15025	COG1376	ErfK ybiS ycfS ynhG family protein
KM317_15030	COG0739	heme binding
KM317_15060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KM317_15065	COG1301	dicarboxylic acid transport
KM317_15095	COG0714	Associated with various cellular activities
KM317_15125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KM317_15145	COG0372	Belongs to the citrate synthase family
KM317_15150	COG0254	rRNA binding
KM317_15160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KM317_15185	COG0314	molybdopterin synthase activity
KM317_15190	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KM317_15195	COG0315	cyclic pyranopterin monophosphate synthase activity
KM317_15205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KM317_15210	COG1234	tRNA 3'-trailer cleavage
KM317_15220	COG0859	PFAM glycosyl transferase family 9
KM317_15240	COG0631	protein serine/threonine phosphatase activity
KM317_15245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KM317_15250	COG0328	RNA-DNA hybrid ribonuclease activity
KM317_15260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM317_15265	COG3942	CHAP domain
KM317_15265	COG1388	LysM domain
KM317_15300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KM317_15310	COG0544	peptidyl-prolyl cis-trans isomerase activity
KM317_15350	COG0473	3-isopropylmalate dehydrogenase activity
KM317_15365	COG4783	chaperone-mediated protein folding
KM317_15380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KM317_15385	COG0248	Ppx GppA phosphatase
KM317_15390	COG0438	transferase activity, transferring glycosyl groups
KM317_15400	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KM317_15415	COG2833	Protein of unknown function (DUF455)
KM317_15435	COG0285	dihydrofolate synthase activity
KM317_15440	COG0588	phosphoglycerate mutase activity
KM317_15460	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KM317_15465	COG4208	sulfate ABC transporter
KM317_15470	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KM317_15475	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KM317_15480	COG0156	8-amino-7-oxononanoate synthase activity
KM317_15495	COG2885	chlorophyll binding
KM317_15500	COG0583	DNA-binding transcription factor activity
KM317_15505	COG2814	Major facilitator Superfamily
KM317_15515	COG0667	Aldo Keto reductase
KM317_15520	COG0604	alcohol dehydrogenase
KM317_15525	COG1902	pentaerythritol trinitrate reductase activity
KM317_15525	COG0446	pyridine nucleotide-disulphide oxidoreductase
KM317_15570	COG0625	glutathione transferase activity
KM317_15575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM317_15585	COG0039	L-malate dehydrogenase activity
KM317_15595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KM317_15600	COG1217	gtp-binding protein TYPA
KM317_15620	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KM317_15630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KM317_15635	COG0203	ribosomal protein L17
KM317_15660	COG0201	protein transport
KM317_15670	COG1841	ribosomal large subunit assembly
KM317_15700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KM317_15705	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KM317_15715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KM317_15720	COG0255	Belongs to the universal ribosomal protein uL29 family
KM317_15745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KM317_15750	COG0089	rRNA binding
KM317_15755	COG0088	Forms part of the polypeptide exit tunnel
KM317_15765	COG0051	transcription antitermination factor activity, RNA binding
KM317_15770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KM317_15775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KM317_15790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KM317_15800	COG0222	ribosome binding
KM317_15815	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KM317_15820	COG0250	Participates in transcription elongation, termination and antitermination
KM317_15825	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM317_15835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KM317_15855	COG0012	GTP binding
KM317_15860	COG0193	aminoacyl-tRNA hydrolase activity
KM317_15870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KM317_15895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KM317_15900	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KM317_15915	COG5297	Belongs to the glycosyl hydrolase family 6
KM317_15920	COG0521	Mo-molybdopterin cofactor biosynthetic process
KM317_15940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM317_15945	COG1295	ribonuclease BN
KM317_15965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KM317_15970	COG1404	Belongs to the peptidase S8 family
KM317_15975	COG1404	Belongs to the peptidase S8 family
KM317_15980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM317_16020	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KM317_16040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM317_16040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM317_16085	COG3634	alkyl hydroperoxide reductase activity
KM317_16090	COG0583	DNA-binding transcription factor activity
KM317_16100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KM317_16120	COG2197	response regulator
KM317_16145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KM317_16150	COG0697	spore germination
KM317_16195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM317_16200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM317_16210	COG2096	Adenosyltransferase
KM317_16220	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KM317_16225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM317_16230	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KM317_16235	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KM317_16240	COG2967	ApaG domain
KM317_16245	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KM317_16275	COG1704	LemA family
KM317_16280	COG0861	Integral membrane protein TerC family
KM317_16285	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KM317_16295	COG0642	Histidine kinase
KM317_16310	COG4181	ATPase activity
KM317_16315	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KM317_16335	COG4771	TonB-dependent receptor
KM317_16345	COG0667	Aldo Keto reductase
KM317_16350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM317_16370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM317_16390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KM317_16460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KM317_16470	COG0494	nUDIX hydrolase
KM317_16485	COG0739	heme binding
KM317_16495	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KM317_16500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KM317_16510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KM317_16515	COG1181	Belongs to the D-alanine--D-alanine ligase family
KM317_16525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KM317_16540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KM317_16555	COG3116	cell division
KM317_16560	COG0275	rRNA processing
KM317_16565	COG2001	Belongs to the MraZ family
KM317_16600	COG0792	nuclease activity
KM317_16605	COG1988	membrane-bound metal-dependent
KM317_16610	COG0277	FAD linked oxidase domain protein
KM317_16630	COG0745	RESPONSE REGULATOR receiver
KM317_16635	COG2205	protein histidine kinase activity
KM317_16645	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KM317_16650	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KM317_16675	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KM317_16680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KM317_16685	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KM317_16700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM317_16700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM317_16710	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KM317_16765	COG0477	Major facilitator Superfamily
KM317_16770	COG0488	(ABC) transporter
KM317_16775	COG0242	peptide deformylase activity
KM317_16785	COG1960	acyl-CoA dehydrogenase activity
KM317_16795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KM317_16805	COG1696	Membrane protein involved in D-alanine export
KM317_16825	COG1215	transferase activity, transferring glycosyl groups
KM317_16835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM317_16890	COG2188	Transcriptional regulator
KM317_16900	COG1450	Type ii and iii secretion system protein
KM317_16915	COG3166	PFAM Fimbrial assembly family protein
KM317_16920	COG3156	type II secretion system protein K
KM317_16925	COG4795	General secretion pathway protein
KM317_16930	COG2165	general secretion pathway protein
KM317_16935	COG4970	Tfp pilus assembly protein FimT
KM317_16940	COG2165	general secretion pathway protein
KM317_16945	COG1459	type II secretion system
KM317_16950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KM317_16965	COG5295	Hep Hag repeat protein
KM317_16970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KM317_16970	COG0047	phosphoribosylformylglycinamidine synthase activity
KM317_16975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KM317_16980	COG4974	Belongs to the 'phage' integrase family
KM317_17005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KM317_17015	COG0525	valine-tRNA ligase activity
KM317_17040	COG1183	phosphatidylcholine synthase activity
KM317_17050	COG0442	prolyl-tRNA aminoacylation
KM317_17065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KM317_17070	COG1127	ABC transporter
KM317_17075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KM317_17075	COG3218	ABC-type transport auxiliary lipoprotein component
KM317_17105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KM317_17110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KM317_17115	COG0662	Cupin 2, conserved barrel domain protein
KM317_17115	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KM317_17140	COG2086	electron transfer activity
KM317_17160	COG0277	FAD linked oxidase domain protein
KM317_17165	COG0300	oxidoreductase activity
KM317_17170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM317_17185	COG0493	'glutamate synthase
KM317_17210	COG0438	transferase activity, transferring glycosyl groups
KM317_17210	COG1216	Glycosyl transferase, family 2
KM317_17215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KM317_17225	COG0438	transferase activity, transferring glycosyl groups
KM317_17225	COG1216	Glycosyl transferase, family 2
KM317_17230	COG0438	transferase activity, transferring glycosyl groups
KM317_17230	COG1216	Glycosyl transferase, family 2
KM317_17235	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KM317_17250	COG0626	cystathionine gamma-synthase activity
KM317_17280	COG0625	glutathione transferase activity
KM317_17295	COG0720	synthase
KM317_17305	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KM317_17310	COG1956	GAF domain-containing protein
KM317_17320	COG4206	TonB-dependent receptor
KM317_17325	COG0583	DNA-binding transcription factor activity
KM317_17340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM317_17345	COG0546	phosphoglycolate phosphatase activity
KM317_17385	COG0339	signal peptide processing
KM317_17390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM317_17400	COG2217	Heavy metal translocating P-type atpase
KM317_17415	COG2132	Multicopper oxidase
KM317_17435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KM317_17445	COG1136	(ABC) transporter
KM317_17455	COG0577	efflux transmembrane transporter activity
KM317_17455	COG1136	(ABC) transporter
KM317_17460	COG0577	efflux transmembrane transporter activity
KM317_17465	COG0577	efflux transmembrane transporter activity
KM317_17470	COG0577	efflux transmembrane transporter activity
KM317_17475	COG0577	efflux transmembrane transporter activity
KM317_17480	COG0577	efflux transmembrane transporter activity
KM317_17480	COG1136	(ABC) transporter
KM317_17485	COG1136	(ABC) transporter
KM317_17485	COG0577	efflux transmembrane transporter activity
KM317_17490	COG0577	efflux transmembrane transporter activity
KM317_17490	COG1136	(ABC) transporter
KM317_17510	COG4191	Histidine kinase
KM317_17525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KM317_17540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KM317_17555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KM317_17565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KM317_17575	COG0356	it plays a direct role in the translocation of protons across the membrane
KM317_17590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM317_17595	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM317_17630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM317_17635	COG0697	spore germination
KM317_17640	COG1666	GTP binding
KM317_17650	COG1187	pseudouridine synthase activity
KM317_17675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM317_17675	COG2205	protein histidine kinase activity
KM317_17700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM317_17730	COG1360	Flagellar Motor Protein
KM317_17770	COG0842	Transport permease protein
KM317_17775	COG1131	(ABC) transporter
KM317_17780	COG0025	NhaP-type Na H and K H
KM317_17790	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
KM317_17795	COG1573	uracil-dna glycosylase
KM317_17805	COG3384	dioxygenase
KM317_17825	COG0667	Aldo Keto reductase
KM317_17830	COG0667	Aldo Keto reductase
KM317_17840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM317_17845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM317_17875	COG5001	Diguanylate cyclase
KM317_17905	COG4106	trans-aconitate 2-methyltransferase activity
KM317_17915	COG2076	Multidrug Resistance protein
KM317_17925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KM317_17950	COG3279	Response regulator of the LytR AlgR family
KM317_17955	COG3275	phosphorelay sensor kinase activity
KM317_17960	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KM317_17980	COG0531	amino acid
KM317_17995	COG0612	Peptidase, M16
KM317_18005	COG0741	lytic transglycosylase activity
KM317_18020	COG2207	Transcriptional regulator
KM317_18030	COG0598	Magnesium transport protein CorA
KM317_18035	COG1113	amino acid transport
KM317_18045	COG0697	spore germination
KM317_18065	COG0583	DNA-binding transcription factor activity
KM317_18155	COG1192	Involved in chromosome partitioning
KM317_18165	COG0840	transmembrane signaling receptor activity
KM317_18190	COG2353	YceI-like domain
KM317_18235	COG0584	glycerophosphoryl diester phosphodiesterase
KM317_18250	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KM317_18270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KM317_18275	COG0459	protein refolding
KM317_18285	COG2356	endonuclease I
KM317_18290	COG1324	tolerance protein
KM317_18300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM317_18310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KM317_18315	COG0511	ligase activity, forming carbon-carbon bonds
KM317_18320	COG0439	Biotin carboxylase
KM317_18335	COG2264	protein methyltransferase activity
KM317_18355	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KM317_18360	COG4589	Belongs to the CDS family
KM317_18385	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KM317_18390	COG0138	bifunctional purine biosynthesis protein purh
KM317_18395	COG0151	Belongs to the GarS family
KM317_18405	COG1289	transmembrane transporter activity
KM317_18410	COG2814	Major facilitator Superfamily
KM317_18490	COG2906	2 iron, 2 sulfur cluster binding
KM317_18495	COG1051	belongs to the nudix hydrolase family
KM317_18520	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
KM317_18535	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM317_18540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM317_18545	COG0730	response to heat
KM317_18550	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KM317_18550	COG4124	Belongs to the glycosyl hydrolase 26 family
KM317_18560	COG0134	indole-3-glycerol-phosphate synthase activity
KM317_18565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KM317_18585	COG1597	lipid kinase activity
KM317_18600	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KM317_18625	COG3179	chitinase
KM317_18635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM317_18640	COG2111	Na H antiporter
KM317_18640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM317_18645	COG1006	Multisubunit Na H antiporter MnhC subunit
KM317_18650	COG0651	ATP synthesis coupled electron transport
KM317_18660	COG2212	antiporter activity
KM317_18665	COG1320	monovalent cation:proton antiporter activity
KM317_18670	COG0530	calcium, potassium:sodium antiporter activity
KM317_18690	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KM317_18710	COG3104	oligopeptide transport
KM317_18725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM317_18750	COG3227	Zinc metalloprotease (Elastase)
KM317_18755	COG0513	Belongs to the DEAD box helicase family
KM317_18780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM317_18790	COG2354	Protein conserved in bacteria
KM317_18810	COG3264	Mechanosensitive ion channel
KM317_18810	COG1196	nuclear chromosome segregation
KM317_18815	COG0604	alcohol dehydrogenase
KM317_18815	COG1028	Short-chain dehydrogenase reductase Sdr
KM317_18815	COG3321	synthase
KM317_18835	COG1595	DNA-templated transcription, initiation
KM317_18855	COG1802	Transcriptional regulator
KM317_18870	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
KM317_18900	COG5599	Phosphatase
KM317_18905	COG1414	Transcriptional regulator
KM317_18915	COG3254	rhamnose metabolic process
KM317_18920	COG4948	Mandelate Racemase Muconate Lactonizing
KM317_18935	COG0546	phosphoglycolate phosphatase activity
KM317_18950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KM317_18965	COG4807	Protein conserved in bacteria
KM317_18975	COG1418	mRNA catabolic process
KM317_18985	COG4773	Receptor
KM317_19000	COG0412	Dienelactone hydrolase
KM317_19055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM317_19085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KM317_19090	COG0753	catalase activity
KM317_19100	COG2197	response regulator
KM317_19105	COG4585	Histidine kinase
KM317_19115	COG1131	(ABC) transporter
KM317_19125	COG1136	(ABC) transporter
KM317_19130	COG0577	efflux transmembrane transporter activity
KM317_19150	COG0697	spore germination
KM317_19165	COG0180	Tryptophanyl-tRNA synthetase
KM317_19175	COG3237	CsbD-like
KM317_19205	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KM317_19210	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KM317_19210	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KM317_19220	COG3228	Belongs to the MtfA family
KM317_19250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM317_19275	COG2084	Dehydrogenase
KM317_19280	COG1902	pentaerythritol trinitrate reductase activity
KM317_19295	COG2814	Major facilitator Superfamily
KM317_19300	COG0583	DNA-binding transcription factor activity
KM317_19320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KM317_19325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KM317_19330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KM317_19335	COG1764	response to oxidative stress
KM317_19340	COG1846	Transcriptional regulator
KM317_19350	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KM317_19360	COG0697	spore germination
KM317_19365	COG0523	cobalamin synthesis protein
KM317_19375	COG1742	UPF0060 membrane protein
KM317_19385	COG3245	cytochrome
KM317_19395	COG1960	acyl-CoA dehydrogenase activity
KM317_19400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KM317_19415	COG1278	Cold shock
KM317_19435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM317_19440	COG3387	PFAM Glycoside hydrolase 15-related
KM317_19445	COG0745	RESPONSE REGULATOR receiver
KM317_19460	COG1404	Belongs to the peptidase S8 family
KM317_19470	COG3100	YcgL domain-containing protein
KM317_19475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KM317_19485	COG0463	Glycosyl transferase, family 2
KM317_19520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KM317_19535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM317_19560	COG1294	oxidase, subunit
KM317_19565	COG1271	oxidase subunit
KM317_19580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM317_19590	COG0408	coproporphyrinogen oxidase activity
KM317_19600	COG2323	membrane
KM317_19605	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM317_19605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM317_19625	COG0589	response to stress
KM317_19655	COG0210	DNA helicase
KM317_19720	COG0463	Glycosyl transferase, family 2
KM317_19730	COG1475	DNA binding
KM317_19735	COG1192	Involved in chromosome partitioning
KM317_19740	COG0357	Ribosomal RNA small subunit methyltransferase G
KM317_19750	COG2091	lysine biosynthetic process via aminoadipic acid
KM317_19780	COG0477	Major facilitator Superfamily
KM317_19810	COG1971	Probably functions as a manganese efflux pump
KM317_19815	COG2205	protein histidine kinase activity
KM317_19825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM317_19830	COG3459	Glycosyltransferase 36 associated
KM317_19835	COG2211	Major facilitator Superfamily
KM317_19840	COG3265	gluconokinase activity
KM317_19845	COG2911	Protein conserved in bacteria
KM317_19850	COG0729	surface antigen
KM317_19870	COG3132	Protein of unknown function, DUF480
KM317_19890	COG3210	domain, Protein
KM317_19890	COG3210	domain, Protein
KM317_19895	COG3210	domain, Protein
KM317_19910	COG0284	orotidine-5'-phosphate decarboxylase activity
KM317_19925	COG1609	Transcriptional regulator
KM317_19935	COG2937	Belongs to the GPAT DAPAT family
KM317_19960	COG2211	Major facilitator Superfamily
KM317_19975	COG3693	PFAM glycoside hydrolase, family 10
KM317_19995	COG3386	PFAM SMP-30 Gluconolaconase
KM317_20040	COG0246	Mannitol dehydrogenase
KM317_20045	COG1472	Belongs to the glycosyl hydrolase 3 family
KM317_20055	COG4948	Mandelate Racemase Muconate Lactonizing
KM317_20065	COG3661	Belongs to the glycosyl hydrolase 67 family
KM317_20075	COG2115	Belongs to the xylose isomerase family
KM317_20080	COG0037	tRNA processing
KM317_20100	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM317_20110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KM317_20120	COG0805	protein transport
KM317_20130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KM317_20130	COG0519	Catalyzes the synthesis of GMP from XMP
KM317_20135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KM317_20160	COG0210	DNA helicase
KM317_20165	COG1435	thymidine kinase activity
KM317_20175	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
KM317_20185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KM317_20200	COG1119	ATPase activity
KM317_20215	COG0706	membrane insertase activity
KM317_20220	COG0594	ribonuclease P activity