locus-tag	class	description
KM547_00010	COG0592	DNA-directed DNA polymerase activity
KM547_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KM547_00020	COG0187	DNA topoisomerase II activity
KM547_00025	COG1266	CAAX protease self-immunity
KM547_00030	COG0501	Belongs to the peptidase M48B family
KM547_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM547_00085	COG1280	lysine exporter protein (LysE YggA)
KM547_00105	COG4772	TonB-dependent receptor
KM547_00120	COG1012	belongs to the aldehyde dehydrogenase family
KM547_00155	COG1304	FMN binding
KM547_00160	COG2186	Transcriptional regulator
KM547_00180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM547_00225	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KM547_00250	COG4771	TonB-dependent receptor
KM547_00280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KM547_00295	COG3507	Belongs to the glycosyl hydrolase 43 family
KM547_00300	COG1609	Transcriptional regulator
KM547_00315	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_00330	COG3186	Phenylalanine-4-hydroxylase
KM547_00335	COG1522	sequence-specific DNA binding
KM547_00340	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM547_00355	COG0671	phosphoesterase, PA-phosphatase related
KM547_00365	COG0861	Integral membrane protein TerC family
KM547_00370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KM547_00400	COG1522	sequence-specific DNA binding
KM547_00405	COG4771	TonB-dependent receptor
KM547_00410	COG0531	amino acid
KM547_00415	COG0154	amidase activity
KM547_00490	COG0477	Major facilitator Superfamily
KM547_00495	COG0302	gtp cyclohydrolase
KM547_00520	COG0730	response to heat
KM547_00540	COG2951	lytic endotransglycosylase activity
KM547_00605	COG1803	Methylglyoxal synthase
KM547_00610	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KM547_00615	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KM547_00620	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KM547_00625	COG0493	'glutamate synthase
KM547_00630	COG0070	glutamate synthase
KM547_00630	COG0067	glutamate synthase
KM547_00630	COG0069	glutamate synthase activity
KM547_00680	COG1205	dead DEAH box helicase
KM547_00680	COG1111	helicase
KM547_00715	COG2271	Major facilitator Superfamily
KM547_00770	COG1192	Involved in chromosome partitioning
KM547_00775	COG2062	phosphohistidine phosphatase, SixA
KM547_00785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM547_00790	COG2050	protein possibly involved in aromatic compounds catabolism
KM547_00800	COG2267	carboxylic ester hydrolase activity
KM547_00815	COG1881	PFAM PEBP family protein
KM547_00820	COG1968	undecaprenyl-diphosphatase activity
KM547_00825	COG0174	glutamine synthetase
KM547_00830	COG0347	Belongs to the P(II) protein family
KM547_00835	COG0004	ammonium transporteR
KM547_00840	COG3852	Histidine kinase
KM547_00845	COG2204	response regulator
KM547_00850	COG2032	superoxide dismutase activity
KM547_00855	COG2032	superoxide dismutase activity
KM547_00865	COG0183	Belongs to the thiolase family
KM547_00905	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KM547_00910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KM547_00920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KM547_00930	COG0612	Peptidase, M16
KM547_00940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM547_00945	COG3177	Filamentation induced by cAMP protein fic
KM547_00960	COG0596	Alpha beta hydrolase
KM547_00970	COG0727	PFAM Uncharacterised protein family (UPF0153)
KM547_00975	COG0318	PFAM AMP-dependent synthetase and ligase
KM547_00990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM547_01000	COG1181	Belongs to the D-alanine--D-alanine ligase family
KM547_01020	COG4232	protein-disulfide reductase activity
KM547_01025	COG0564	pseudouridine synthase activity
KM547_01050	COG0681	Belongs to the peptidase S26 family
KM547_01070	COG0583	DNA-binding transcription factor activity
KM547_01075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KM547_01080	COG2224	Isocitrate lyase
KM547_01085	COG3706	GGDEF domain
KM547_01110	COG0659	secondary active sulfate transmembrane transporter activity
KM547_01140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM547_01145	COG2130	NADP-dependent
KM547_01160	COG1187	pseudouridine synthase activity
KM547_01180	COG0084	hydrolase, TatD family'
KM547_01270	COG0842	Transport permease protein
KM547_01275	COG1131	(ABC) transporter
KM547_01280	COG0633	Ferredoxin
KM547_01280	COG0543	2 iron, 2 sulfur cluster binding
KM547_01290	COG1476	TRANSCRIPTIONal
KM547_01300	COG4555	ABC transporter
KM547_01320	COG0625	glutathione transferase activity
KM547_01430	COG1199	ATP-dependent helicase activity
KM547_01475	COG0628	permease
KM547_01495	COG2133	pyrroloquinoline quinone binding
KM547_01515	COG0456	acetyltransferase
KM547_01515	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM547_01555	COG2801	Transposase and inactivated derivatives
KM547_01565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM547_01625	COG5463	Belongs to the UPF0441 family
KM547_01630	COG0754	glutathionylspermidine amidase activity
KM547_01640	COG0714	Associated with various cellular activities
KM547_01675	COG1522	sequence-specific DNA binding
KM547_01695	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KM547_01710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM547_01715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM547_01740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KM547_01760	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_01775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KM547_01785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM547_01790	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KM547_01850	COG0606	chelatase, subunit chli
KM547_01855	COG2960	long-chain fatty acid transporting porin activity
KM547_01880	COG1166	arginine decarboxylase activity
KM547_01885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KM547_01890	COG1819	glycosyl
KM547_01895	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KM547_01895	COG2755	lipolytic protein G-D-S-L family
KM547_01920	COG4221	oxidoreductase activity
KM547_01940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM547_01960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KM547_01970	COG2814	Major facilitator Superfamily
KM547_01980	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KM547_01985	COG0739	heme binding
KM547_01990	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KM547_02040	COG1064	alcohol dehydrogenase
KM547_02045	COG2234	aminopeptidase activity
KM547_02055	COG4942	peptidase
KM547_02060	COG0793	Belongs to the peptidase S41A family
KM547_02095	COG0531	amino acid
KM547_02100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KM547_02100	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KM547_02105	COG1486	melibiose metabolic process
KM547_02120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KM547_02125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KM547_02130	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
KM547_02160	COG0109	protoheme IX farnesyltransferase activity
KM547_02175	COG0358	DNA primase activity
KM547_02180	COG1295	ribonuclease BN
KM547_02200	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KM547_02205	COG2308	Evidence 4 Homologs of previously reported genes of
KM547_02220	COG2133	pyrroloquinoline quinone binding
KM547_02245	COG0531	amino acid
KM547_02255	COG4948	Mandelate Racemase Muconate Lactonizing
KM547_02265	COG4771	TonB-dependent receptor
KM547_02320	COG5383	Protein conserved in bacteria
KM547_02340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM547_02355	COG1652	LysM domain
KM547_02365	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KM547_02425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KM547_02430	COG3118	belongs to the thioredoxin family
KM547_02440	COG2884	Cell division ATP-binding protein ftsE
KM547_02445	COG2177	Part of the ABC transporter FtsEX involved in
KM547_02450	COG2201	protein-glutamate methylesterase activity
KM547_02455	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KM547_02460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM547_02465	COG2860	membrane
KM547_02470	COG1252	NADH dehydrogenase
KM547_02475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KM547_02490	COG0534	Mate efflux family protein
KM547_02495	COG0616	signal peptide processing
KM547_02505	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_02520	COG0009	L-threonylcarbamoyladenylate synthase
KM547_02525	COG1754	DNA topoisomerase type I activity
KM547_02525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM547_02530	COG1714	RDD family
KM547_02545	COG0758	DNA mediated transformation
KM547_02550	COG1652	LysM domain
KM547_02555	COG0242	peptide deformylase activity
KM547_02560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KM547_02565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KM547_02565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KM547_02570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KM547_02585	COG1215	transferase activity, transferring glycosyl groups
KM547_02605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KM547_02620	COG1490	D-aminoacyl-tRNA deacylase activity
KM547_02625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM547_02640	COG1609	Transcriptional regulator
KM547_02650	COG0366	Alpha amylase catalytic
KM547_02655	COG0366	Alpha amylase catalytic
KM547_02735	COG4974	Belongs to the 'phage' integrase family
KM547_02765	COG1074	ATP-dependent DNA helicase activity
KM547_02780	COG0596	Alpha beta hydrolase
KM547_02795	COG1309	transcriptional regulator
KM547_02830	COG0840	transmembrane signaling receptor activity
KM547_02845	COG3546	catalase activity
KM547_02850	COG3685	Protein conserved in bacteria
KM547_02855	COG3685	Protein conserved in bacteria
KM547_02860	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_02870	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KM547_02885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KM547_02900	COG0028	Belongs to the TPP enzyme family
KM547_02905	COG4191	Histidine kinase
KM547_02930	COG1648	precorrin-2 dehydrogenase activity
KM547_02930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KM547_02935	COG0784	Response regulator, receiver
KM547_02935	COG2198	Histidine kinase
KM547_02935	COG2205	protein histidine kinase activity
KM547_02940	COG1116	anion transmembrane transporter activity
KM547_02940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM547_02955	COG2223	nitrite transmembrane transporter activity
KM547_02960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM547_02965	COG2146	nitrite reductase [NAD(P)H] activity
KM547_02970	COG0243	molybdopterin cofactor binding
KM547_02995	COG1640	4-alpha-glucanotransferase
KM547_03000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KM547_03010	COG0297	glycogen (starch) synthase activity
KM547_03020	COG2204	response regulator
KM547_03045	COG0181	hydroxymethylbilane synthase activity
KM547_03060	COG1733	regulation of RNA biosynthetic process
KM547_03075	COG1505	serine-type exopeptidase activity
KM547_03080	COG0436	Aminotransferase
KM547_03090	COG2832	Protein of unknown function (DUF454)
KM547_03145	COG2226	methyltransferase
KM547_03175	COG0308	aminopeptidase N
KM547_03180	COG0596	Alpha beta hydrolase
KM547_03180	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM547_03205	COG2010	Cytochrome c
KM547_03215	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KM547_03225	COG3284	Transcriptional regulator
KM547_03230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM547_03235	COG1077	Cell shape determining protein MreB Mrl
KM547_03240	COG1792	Involved in formation and maintenance of cell shape
KM547_03250	COG0768	penicillin binding
KM547_03255	COG0772	Belongs to the SEDS family
KM547_03270	COG2951	lytic endotransglycosylase activity
KM547_03280	COG1686	Belongs to the peptidase S11 family
KM547_03295	COG0321	lipoyl(octanoyl) transferase activity
KM547_03300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KM547_03330	COG1056	cytidyltransferase-related domain
KM547_03330	COG1051	belongs to the nudix hydrolase family
KM547_03355	COG1090	epimerase
KM547_03365	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KM547_03370	COG0673	inositol 2-dehydrogenase activity
KM547_03375	COG2823	Periplasmic or secreted lipoprotein
KM547_03385	COG2205	protein histidine kinase activity
KM547_03385	COG2202	Pas domain
KM547_03390	COG0784	Response regulator, receiver
KM547_03395	COG4191	Histidine kinase
KM547_03405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KM547_03410	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_03425	COG4305	rare lipoprotein A
KM547_03435	COG3250	beta-galactosidase activity
KM547_03450	COG2188	Transcriptional regulator
KM547_03460	COG1609	Transcriptional regulator
KM547_03465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KM547_03470	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KM547_03525	COG0494	nUDIX hydrolase
KM547_03535	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KM547_03560	COG2226	methyltransferase
KM547_03600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KM547_03620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM547_03640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM547_03645	COG0667	Aldo Keto reductase
KM547_03680	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KM547_03685	COG4181	ATPase activity
KM547_03700	COG0642	Histidine kinase
KM547_03710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KM547_03715	COG0861	Integral membrane protein TerC family
KM547_03720	COG1704	LemA family
KM547_03750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KM547_03755	COG2967	ApaG domain
KM547_03760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KM547_03765	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KM547_03770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM547_03775	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KM547_03785	COG2096	Adenosyltransferase
KM547_03795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM547_03800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM547_03815	COG0673	inositol 2-dehydrogenase activity
KM547_03840	COG0697	spore germination
KM547_03845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KM547_03870	COG2197	response regulator
KM547_03880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM547_03890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KM547_03900	COG0583	DNA-binding transcription factor activity
KM547_03905	COG3634	alkyl hydroperoxide reductase activity
KM547_03950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM547_03950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM547_04015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM547_04020	COG1404	Belongs to the peptidase S8 family
KM547_04030	COG1404	Belongs to the peptidase S8 family
KM547_04035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KM547_04055	COG1295	ribonuclease BN
KM547_04060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM547_04080	COG0521	Mo-molybdopterin cofactor biosynthetic process
KM547_04085	COG5297	Belongs to the glycosyl hydrolase family 6
KM547_04105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KM547_04110	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KM547_04135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KM547_04145	COG0193	aminoacyl-tRNA hydrolase activity
KM547_04150	COG0012	GTP binding
KM547_04170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KM547_04180	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM547_04185	COG0250	Participates in transcription elongation, termination and antitermination
KM547_04190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KM547_04205	COG0222	ribosome binding
KM547_04215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KM547_04230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KM547_04235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KM547_04240	COG0051	transcription antitermination factor activity, RNA binding
KM547_04250	COG0088	Forms part of the polypeptide exit tunnel
KM547_04255	COG0089	rRNA binding
KM547_04260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KM547_04275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KM547_04285	COG0255	Belongs to the universal ribosomal protein uL29 family
KM547_04290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KM547_04300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KM547_04305	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KM547_04335	COG1841	ribosomal large subunit assembly
KM547_04345	COG0201	protein transport
KM547_04370	COG0203	ribosomal protein L17
KM547_04375	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KM547_04385	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KM547_04405	COG1217	gtp-binding protein TYPA
KM547_04410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KM547_04420	COG0039	L-malate dehydrogenase activity
KM547_04440	COG0625	glutathione transferase activity
KM547_04485	COG0446	pyridine nucleotide-disulphide oxidoreductase
KM547_04485	COG1902	pentaerythritol trinitrate reductase activity
KM547_04490	COG0604	alcohol dehydrogenase
KM547_04495	COG0667	Aldo Keto reductase
KM547_04505	COG2814	Major facilitator Superfamily
KM547_04510	COG0583	DNA-binding transcription factor activity
KM547_04515	COG2885	chlorophyll binding
KM547_04530	COG0156	8-amino-7-oxononanoate synthase activity
KM547_04535	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KM547_04540	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KM547_04545	COG4208	sulfate ABC transporter
KM547_04550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KM547_04570	COG0588	phosphoglycerate mutase activity
KM547_04575	COG0285	dihydrofolate synthase activity
KM547_04595	COG2833	Protein of unknown function (DUF455)
KM547_04605	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KM547_04610	COG0671	phosphoesterase, PA-phosphatase related
KM547_04615	COG0438	transferase activity, transferring glycosyl groups
KM547_04625	COG0248	Ppx GppA phosphatase
KM547_04630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KM547_04645	COG4783	chaperone-mediated protein folding
KM547_04660	COG0473	3-isopropylmalate dehydrogenase activity
KM547_04695	COG0544	peptidyl-prolyl cis-trans isomerase activity
KM547_04705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KM547_04745	COG1388	LysM domain
KM547_04745	COG3942	CHAP domain
KM547_04750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM547_04760	COG0328	RNA-DNA hybrid ribonuclease activity
KM547_04765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KM547_04770	COG0631	protein serine/threonine phosphatase activity
KM547_04790	COG0859	PFAM glycosyl transferase family 9
KM547_04800	COG1234	tRNA 3'-trailer cleavage
KM547_04805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KM547_04815	COG0315	cyclic pyranopterin monophosphate synthase activity
KM547_04820	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KM547_04825	COG0314	molybdopterin synthase activity
KM547_04915	COG1002	Type II restriction enzyme, methylase subunits
KM547_04955	COG0537	adenosine 5'-monophosphoramidase activity
KM547_04975	COG0714	Associated with various cellular activities
KM547_05000	COG1399	metal-binding, possibly nucleic acid-binding protein
KM547_05005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KM547_05010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM547_05015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KM547_05020	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_05025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM547_05035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KM547_05040	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KM547_05045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KM547_05065	COG4115	mRNA cleavage
KM547_05070	COG2161	toxin-antitoxin pair type II binding
KM547_05100	COG0587	DNA-directed DNA polymerase activity
KM547_05115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KM547_05120	COG0372	Belongs to the citrate synthase family
KM547_05165	COG2373	Large extracellular alpha-helical protein
KM547_05195	COG4953	penicillin-binding protein 1C
KM547_05205	COG0678	peroxiredoxin activity
KM547_05230	COG0604	alcohol dehydrogenase
KM547_05235	COG0330	HflC and HflK could
KM547_05240	COG0330	HflC and HflK could
KM547_05255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KM547_05315	COG4804	nuclease activity
KM547_05320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KM547_05360	COG0492	ferredoxin-NADP+ reductase activity
KM547_05380	COG3459	Glycosyltransferase 36 associated
KM547_05390	COG1063	alcohol dehydrogenase
KM547_05415	COG0753	catalase activity
KM547_05420	COG4251	negative regulation of phosphorylation
KM547_05420	COG3706	GGDEF domain
KM547_05420	COG2203	Gaf domain
KM547_05420	COG5001	Diguanylate cyclase
KM547_05425	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KM547_05425	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KM547_05450	COG2814	Major facilitator Superfamily
KM547_05470	COG2194	sulfuric ester hydrolase activity
KM547_05480	COG0745	RESPONSE REGULATOR receiver
KM547_05485	COG2205	protein histidine kinase activity
KM547_05505	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KM547_05510	COG2894	cell division
KM547_05515	COG0850	regulation of cytokinetic process
KM547_05525	COG4585	Histidine kinase
KM547_05545	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM547_05550	COG1216	Glycosyl transferase, family 2
KM547_05555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM547_05565	COG1199	ATP-dependent helicase activity
KM547_05585	COG0189	ligase activity
KM547_05600	COG0835	chemotaxis
KM547_05605	COG0840	transmembrane signaling receptor activity
KM547_05610	COG0784	Response regulator, receiver
KM547_05610	COG2198	Histidine kinase
KM547_05610	COG0643	Histidine kinase
KM547_05615	COG2201	protein-glutamate methylesterase activity
KM547_05670	COG3142	Participates in the control of copper homeostasis
KM547_05675	COG1446	asparaginase
KM547_05735	COG3537	Alpha-1,2-mannosidase
KM547_05745	COG1472	Belongs to the glycosyl hydrolase 3 family
KM547_05760	COG1472	Belongs to the glycosyl hydrolase 3 family
KM547_05770	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KM547_05775	COG1388	LysM domain
KM547_05775	COG3858	chitin binding
KM547_05790	COG0837	glucose binding
KM547_05800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KM547_05810	COG0494	nUDIX hydrolase
KM547_05815	COG1218	3'(2'),5'-bisphosphate nucleotidase
KM547_05820	COG3956	TIGRFAM MazG family protein
KM547_05825	COG1742	UPF0060 membrane protein
KM547_05830	COG0330	HflC and HflK could
KM547_05870	COG0697	spore germination
KM547_05900	COG2124	cytochrome p450
KM547_05905	COG2124	cytochrome p450
KM547_05910	COG1141	Ferredoxin
KM547_05915	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_05920	COG2124	cytochrome p450
KM547_05925	COG0142	geranyltranstransferase activity
KM547_05930	COG1657	PFAM Prenyltransferase squalene oxidase
KM547_05940	COG1304	FMN binding
KM547_05945	COG1960	acyl-CoA dehydrogenase activity
KM547_05990	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KM547_05995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM547_06000	COG0463	Glycosyl transferase, family 2
KM547_06005	COG0517	IMP dehydrogenase activity
KM547_06010	COG2982	Protein involved in outer membrane biogenesis
KM547_06015	COG1272	protein, Hemolysin III
KM547_06020	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KM547_06025	COG0739	heme binding
KM547_06030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM547_06035	COG0626	cystathionine gamma-synthase activity
KM547_06040	COG0460	homoserine dehydrogenase
KM547_06040	COG0527	aspartate kinase activity
KM547_06045	COG0596	Alpha beta hydrolase
KM547_06045	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM547_06055	COG1760	l-serine dehydratase
KM547_06070	COG3038	cytochrome b561
KM547_06090	COG2814	Major facilitator Superfamily
KM547_06100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KM547_06110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM547_06115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM547_06135	COG0259	pyridoxamine-phosphate oxidase activity
KM547_06190	COG0519	Catalyzes the synthesis of GMP from XMP
KM547_06205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KM547_06225	COG0840	transmembrane signaling receptor activity
KM547_06235	COG1113	amino acid transport
KM547_06255	COG2239	Acts as a magnesium transporter
KM547_06260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KM547_06265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM547_06275	COG1660	Displays ATPase and GTPase activities
KM547_06285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM547_06300	COG1137	ATPase activity
KM547_06315	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KM547_06380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KM547_06405	COG0628	permease
KM547_06415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KM547_06420	COG3178	'Phosphotransferase
KM547_06435	COG1555	photosystem II stabilization
KM547_06455	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KM547_06460	COG1477	protein flavinylation
KM547_06485	COG4774	siderophore transport
KM547_06490	COG2146	nitrite reductase [NAD(P)H] activity
KM547_06500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KM547_06505	COG0719	Fe-S assembly protein
KM547_06510	COG0396	ATPase activity
KM547_06515	COG0719	Fe-S assembly protein
KM547_06530	COG0693	protein deglycase activity
KM547_06545	COG0739	heme binding
KM547_06560	COG1764	response to oxidative stress
KM547_06570	COG0384	phenazine biosynthesis protein PhzF
KM547_06575	COG0527	aspartate kinase activity
KM547_06600	COG0142	geranyltranstransferase activity
KM547_06605	COG0629	single-stranded DNA binding
KM547_06610	COG3550	peptidyl-serine autophosphorylation
KM547_06625	COG3104	oligopeptide transport
KM547_06630	COG1297	OPT oligopeptide transporter protein
KM547_06635	COG0823	Involved in the tonB-independent uptake of proteins
KM547_06635	COG1506	peptidase
KM547_06655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KM547_06665	COG2879	small protein
KM547_06670	COG1966	Carbon starvation protein
KM547_06695	COG1515	deoxyribonuclease V activity
KM547_06715	COG2211	Major facilitator Superfamily
KM547_06740	COG5001	Diguanylate cyclase
KM547_06740	COG4251	negative regulation of phosphorylation
KM547_06740	COG3706	GGDEF domain
KM547_06740	COG2203	Gaf domain
KM547_06745	COG0835	chemotaxis
KM547_06750	COG0840	transmembrane signaling receptor activity
KM547_06755	COG0840	transmembrane signaling receptor activity
KM547_06760	COG0840	transmembrane signaling receptor activity
KM547_06765	COG0643	Histidine kinase
KM547_06765	COG2198	Histidine kinase
KM547_06775	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KM547_06795	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KM547_06815	COG4452	Inner membrane protein CreD
KM547_06840	COG0735	belongs to the Fur family
KM547_06920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM547_07015	COG1187	pseudouridine synthase activity
KM547_07040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KM547_07065	COG1132	(ABC) transporter
KM547_07130	COG1981	membrane
KM547_07155	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KM547_07160	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KM547_07170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KM547_07180	COG0750	zinc metalloprotease
KM547_07185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KM547_07190	COG0575	Belongs to the CDS family
KM547_07195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KM547_07205	COG0528	UMP kinase activity
KM547_07215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KM547_07255	COG0024	Methionine aminopeptidase
KM547_07270	COG1393	Belongs to the ArsC family
KM547_07275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM547_07285	COG0367	asparagine synthase
KM547_07325	COG1566	PFAM secretion protein HlyD family protein
KM547_07330	COG2814	Major facilitator Superfamily
KM547_07365	COG0557	exoribonuclease II activity
KM547_07375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM547_07385	COG3668	Plasmid stabilization system
KM547_07400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KM547_07420	COG0704	Plays a role in the regulation of phosphate uptake
KM547_07430	COG0581	inorganic phosphate transmembrane transporter activity
KM547_07435	COG0573	inorganic phosphate transmembrane transporter activity
KM547_07440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM547_07445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM547_07465	COG0659	secondary active sulfate transmembrane transporter activity
KM547_07470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KM547_07480	COG1024	Enoyl-CoA hydratase
KM547_07535	COG0784	Response regulator, receiver
KM547_07535	COG2205	protein histidine kinase activity
KM547_07535	COG5002	protein histidine kinase activity
KM547_07540	COG2733	membrane
KM547_07560	COG0686	Belongs to the AlaDH PNT family
KM547_07565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM547_07570	COG1396	sequence-specific DNA binding
KM547_07570	COG1917	Cupin 2, conserved barrel domain protein
KM547_07575	COG1012	belongs to the aldehyde dehydrogenase family
KM547_07590	COG2223	nitrite transmembrane transporter activity
KM547_07600	COG0243	molybdopterin cofactor binding
KM547_07615	COG0477	Major facilitator Superfamily
KM547_07620	COG3706	GGDEF domain
KM547_07625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM547_07630	COG0174	glutamine synthetase
KM547_07635	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KM547_07640	COG0174	glutamine synthetase
KM547_07660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KM547_07680	COG3842	ATPase activity
KM547_07685	COG1176	ABC-type spermidine putrescine transport system, permease component I
KM547_07690	COG1177	transmembrane transport
KM547_07695	COG1012	belongs to the aldehyde dehydrogenase family
KM547_07710	COG4535	Mg2 and Co2 transporter CorC
KM547_07725	COG1702	phosphate starvation-inducible protein PhoH
KM547_07740	COG0741	lytic transglycosylase activity
KM547_07745	COG0723	plastoquinol--plastocyanin reductase activity
KM547_07750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KM547_07760	COG2857	Cytochrome c1
KM547_07765	COG0625	glutathione transferase activity
KM547_07770	COG2969	positive regulation of protein catabolic process
KM547_07810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KM547_07815	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_07820	COG2095	MarC family integral membrane protein
KM547_07830	COG1611	Belongs to the LOG family
KM547_07835	COG3275	phosphorelay sensor kinase activity
KM547_07880	COG0556	nucleotide-excision repair
KM547_07895	COG3505	Type IV secretory pathway VirD4
KM547_07915	COG2948	multi-organism process
KM547_07980	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KM547_07990	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KM547_07995	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KM547_08045	COG0438	transferase activity, transferring glycosyl groups
KM547_08050	COG0438	transferase activity, transferring glycosyl groups
KM547_08060	COG0438	transferase activity, transferring glycosyl groups
KM547_08080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KM547_08090	COG1960	acyl-CoA dehydrogenase activity
KM547_08130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KM547_08135	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KM547_08135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KM547_08140	COG0802	atpase or kinase
KM547_08145	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM547_08150	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KM547_08175	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_08210	COG2081	HI0933 family
KM547_08215	COG4681	YaeQ
KM547_08220	COG0564	pseudouridine synthase activity
KM547_08230	COG0625	glutathione transferase activity
KM547_08235	COG0657	acetylesterase activity
KM547_08265	COG0513	Belongs to the DEAD box helicase family
KM547_08270	COG0488	(ABC) transporter
KM547_08285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM547_08295	COG1472	Belongs to the glycosyl hydrolase 3 family
KM547_08330	COG1846	Transcriptional regulator
KM547_08335	COG0339	signal peptide processing
KM547_08345	COG0386	Belongs to the glutathione peroxidase family
KM547_08415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KM547_08420	COG0084	hydrolase, TatD family'
KM547_08435	COG1960	acyl-CoA dehydrogenase activity
KM547_08445	COG0305	Participates in initiation and elongation during chromosome replication
KM547_08450	COG0415	Belongs to the DNA photolyase family
KM547_08465	COG0583	DNA-binding transcription factor activity
KM547_08480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM547_08555	COG1404	Belongs to the peptidase S8 family
KM547_08560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KM547_08565	COG2867	negative regulation of translational initiation
KM547_08575	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KM547_08580	COG0735	belongs to the Fur family
KM547_08585	COG0497	DNA recombination
KM547_08590	COG1420	regulation of RNA biosynthetic process
KM547_08595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KM547_08600	COG0443	Heat shock 70 kDa protein
KM547_08605	COG0484	heat shock protein binding
KM547_08610	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
KM547_08615	COG0287	Prephenate dehydrogenase
KM547_08615	COG1605	Chorismate mutase
KM547_08625	COG1132	(ABC) transporter
KM547_08680	COG2850	peptidyl-arginine hydroxylation
KM547_08720	COG1131	(ABC) transporter
KM547_08725	COG1725	Transcriptional regulator
KM547_08735	COG0386	Belongs to the glutathione peroxidase family
KM547_08750	COG2900	Belongs to the SlyX family
KM547_08770	COG0646	methionine synthase
KM547_08770	COG1410	methionine synthase
KM547_08775	COG0646	methionine synthase
KM547_08775	COG1410	methionine synthase
KM547_08780	COG2226	methyltransferase
KM547_08785	COG1960	acyl-CoA dehydrogenase activity
KM547_08790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM547_08795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM547_08805	COG2902	Dehydrogenase
KM547_08835	COG2925	Exonuclease
KM547_08845	COG3844	kynureninase activity
KM547_08855	COG0662	Cupin 2, conserved barrel domain protein
KM547_08860	COG0288	reversible hydration of carbon dioxide
KM547_08905	COG2197	response regulator
KM547_08930	COG0316	Belongs to the HesB IscA family
KM547_08935	COG2977	Belongs to the P-Pant transferase superfamily
KM547_08970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KM547_08975	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KM547_08985	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KM547_09020	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KM547_09035	COG1228	amidohydrolase
KM547_09050	COG4221	oxidoreductase activity
KM547_09090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KM547_09095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KM547_09100	COG1605	Chorismate mutase
KM547_09100	COG0077	Prephenate dehydratase
KM547_09175	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_09185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM547_09205	COG2201	protein-glutamate methylesterase activity
KM547_09210	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KM547_09215	COG2197	response regulator
KM547_09235	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KM547_09240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KM547_09245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KM547_09250	COG1256	bacterial-type flagellum assembly
KM547_09250	COG4786	Flagellar basal body rod
KM547_09260	COG1706	bacterial-type flagellum-dependent cell motility
KM547_09265	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KM547_09280	COG1749	Flagellar hook protein flgE
KM547_09290	COG1558	bacterial-type flagellum-dependent cell motility
KM547_09300	COG0835	chemotaxis
KM547_09300	COG0784	Response regulator, receiver
KM547_09345	COG1116	anion transmembrane transporter activity
KM547_09360	COG2915	High frequency lysogenization protein hflD homolog
KM547_09365	COG0482	sulfurtransferase activity
KM547_09385	COG0542	response to heat
KM547_09395	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KM547_09405	COG0492	ferredoxin-NADP+ reductase activity
KM547_09410	COG1674	ftsk spoiiie
KM547_09440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KM547_09445	COG0038	chloride channel
KM547_09480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM547_09515	COG1595	DNA-templated transcription, initiation
KM547_09535	COG3038	cytochrome b561
KM547_09565	COG2244	polysaccharide biosynthetic process
KM547_09605	COG0438	transferase activity, transferring glycosyl groups
KM547_09610	COG0438	transferase activity, transferring glycosyl groups
KM547_09630	COG1132	(ABC) transporter
KM547_09640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM547_09690	COG4644	lycopene metabolic process
KM547_09695	COG1649	PFAM Uncharacterised BCR, COG1649
KM547_09705	COG4644	lycopene metabolic process
KM547_09760	COG5000	phosphorelay sensor kinase activity
KM547_09760	COG5002	protein histidine kinase activity
KM547_09820	COG0784	Response regulator, receiver
KM547_09820	COG2205	protein histidine kinase activity
KM547_09825	COG2183	response to ionizing radiation
KM547_09830	COG0784	Response regulator, receiver
KM547_09830	COG4191	Histidine kinase
KM547_09840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM547_09840	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KM547_09860	COG3243	poly(R)-hydroxyalkanoic acid synthase
KM547_09870	COG1183	phosphatidylcholine synthase activity
KM547_09875	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_09890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KM547_09900	COG0668	transmembrane transport
KM547_09905	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KM547_09920	COG1914	H( )-stimulated, divalent metal cation uptake system
KM547_09930	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KM547_09935	COG1501	Belongs to the glycosyl hydrolase 31 family
KM547_09965	COG0475	glutathione-regulated potassium exporter activity
KM547_09965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM547_09970	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM547_09980	COG0746	molybdenum cofactor guanylyltransferase activity
KM547_09990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KM547_10000	COG1426	Protein conserved in bacteria
KM547_10010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KM547_10025	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM547_10025	COG1024	Enoyl-CoA hydratase
KM547_10030	COG0183	Belongs to the thiolase family
KM547_10035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM547_10045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KM547_10050	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KM547_10060	COG0776	regulation of translation
KM547_10065	COG0539	negative regulation of cytoplasmic translation
KM547_10070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KM547_10075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KM547_10085	COG2957	Belongs to the agmatine deiminase family
KM547_10090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KM547_10130	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KM547_10130	COG0316	Belongs to the HesB IscA family
KM547_10145	COG0428	transporter
KM547_10160	COG1530	ribonuclease E activity
KM547_10190	COG1677	Flagellar hook-basal body complex protein FliE
KM547_10240	COG3190	flagellar
KM547_10250	COG1987	bacterial-type flagellum assembly
KM547_10255	COG1684	flagellar biosynthetic protein fliR
KM547_10305	COG0643	Histidine kinase
KM547_10305	COG0784	Response regulator, receiver
KM547_10305	COG2198	Histidine kinase
KM547_10310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM547_10320	COG1192	Involved in chromosome partitioning
KM547_10335	COG0745	RESPONSE REGULATOR receiver
KM547_10345	COG0840	transmembrane signaling receptor activity
KM547_10350	COG0840	transmembrane signaling receptor activity
KM547_10355	COG0840	transmembrane signaling receptor activity
KM547_10360	COG0840	transmembrane signaling receptor activity
KM547_10370	COG0840	transmembrane signaling receptor activity
KM547_10375	COG0840	transmembrane signaling receptor activity
KM547_10380	COG0840	transmembrane signaling receptor activity
KM547_10390	COG0840	transmembrane signaling receptor activity
KM547_10400	COG0835	chemotaxis
KM547_10410	COG0840	transmembrane signaling receptor activity
KM547_10420	COG0840	transmembrane signaling receptor activity
KM547_10460	COG5001	Diguanylate cyclase
KM547_10465	COG3706	GGDEF domain
KM547_10505	COG0318	PFAM AMP-dependent synthetase and ligase
KM547_10510	COG1024	Enoyl-CoA hydratase
KM547_10515	COG0784	Response regulator, receiver
KM547_10515	COG2205	protein histidine kinase activity
KM547_10515	COG2198	Histidine kinase
KM547_10525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KM547_10555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KM547_10560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KM547_10570	COG0505	Belongs to the CarA family
KM547_10580	COG2258	MOSC domain
KM547_10585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM547_10595	COG1918	ferrous iron import across plasma membrane
KM547_10595	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM547_10605	COG1024	Enoyl-CoA hydratase
KM547_10625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KM547_10645	COG0277	FAD linked oxidase domain protein
KM547_10650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KM547_10665	COG0531	amino acid
KM547_10670	COG0531	amino acid
KM547_10675	COG0235	Class ii aldolase
KM547_10680	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KM547_10685	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
KM547_10700	COG0140	phosphoribosyl-ATP diphosphatase activity
KM547_10700	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KM547_10715	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KM547_10730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KM547_10735	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KM547_10745	COG0124	histidyl-tRNA synthetase
KM547_10750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM547_10760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KM547_10770	COG2951	lytic endotransglycosylase activity
KM547_10780	COG0460	homoserine dehydrogenase
KM547_10780	COG0527	aspartate kinase activity
KM547_10795	COG1012	belongs to the aldehyde dehydrogenase family
KM547_10810	COG0167	dihydroorotate dehydrogenase activity
KM547_10815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM547_10825	COG0210	DNA helicase
KM547_10830	COG0671	phosphoesterase, PA-phosphatase related
KM547_10845	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
KM547_10865	COG0166	Belongs to the GPI family
KM547_10880	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KM547_10890	COG0617	tRNA 3'-terminal CCA addition
KM547_10910	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM547_10915	COG0477	Major facilitator Superfamily
KM547_10920	COG2115	Belongs to the xylose isomerase family
KM547_10925	COG1070	Carbohydrate kinase
KM547_10935	COG1501	Belongs to the glycosyl hydrolase 31 family
KM547_10960	COG0800	Aldolase
KM547_10975	COG3734	2-keto-3-deoxy-galactonokinase
KM547_10980	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KM547_10990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KM547_11000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KM547_11005	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KM547_11020	COG0352	thiamine-phosphate diphosphorylase activity
KM547_11020	COG0351	phosphomethylpyrimidine kinase
KM547_11045	COG0583	DNA-binding transcription factor activity
KM547_11050	COG1741	Belongs to the pirin family
KM547_11085	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KM547_11090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KM547_11095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KM547_11100	COG1546	Belongs to the CinA family
KM547_11105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KM547_11115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KM547_11120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KM547_11125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM547_11130	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KM547_11135	COG1534	Rna-binding protein
KM547_11150	COG1238	metal cluster binding
KM547_11160	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KM547_11175	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KM547_11180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KM547_11185	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KM547_11225	COG1253	flavin adenine dinucleotide binding
KM547_11240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM547_11280	COG0069	glutamate synthase activity
KM547_11285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KM547_11300	COG1609	Transcriptional regulator
KM547_11305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM547_11305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KM547_11310	COG1105	Belongs to the carbohydrate kinase PfkB family
KM547_11315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM547_11315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM547_11345	COG0577	efflux transmembrane transporter activity
KM547_11345	COG1136	(ABC) transporter
KM547_11400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM547_11410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM547_11415	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
KM547_11425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM547_11435	COG0348	domain, Protein
KM547_11465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KM547_11480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KM547_11490	COG1663	tetraacyldisaccharide 4'-kinase activity
KM547_11495	COG1132	(ABC) transporter
KM547_11500	COG0848	biopolymer transport protein
KM547_11505	COG0811	peptide transport
KM547_11525	COG4591	ABC-type transport system involved in lipoprotein release permease component
KM547_11535	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KM547_11550	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KM547_11555	COG2009	succinate dehydrogenase
KM547_11565	COG0354	folic acid binding
KM547_11570	COG3842	ATPase activity
KM547_11575	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM547_11590	COG0129	dihydroxy-acid dehydratase activity
KM547_11605	COG0395	ABC-type sugar transport system, permease component
KM547_11640	COG2350	Protein conserved in bacteria
KM547_11645	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KM547_11655	COG1187	pseudouridine synthase activity
KM547_11685	COG0436	Aminotransferase
KM547_11690	COG4133	protoheme IX ABC transporter activity
KM547_11735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM547_11740	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KM547_11745	COG4988	ABC transporter
KM547_11755	COG1294	oxidase, subunit
KM547_11780	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KM547_11800	COG0165	Argininosuccinate lyase
KM547_11805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KM547_11815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KM547_11820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM547_11825	COG0137	argininosuccinate synthase activity
KM547_11830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KM547_11845	COG2166	iron-sulfur cluster assembly
KM547_11850	COG2814	Major facilitator Superfamily
KM547_11890	COG2010	Cytochrome c
KM547_11890	COG4993	Dehydrogenase
KM547_11915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KM547_11925	COG4677	pectinesterase activity
KM547_11930	COG5434	Belongs to the glycosyl hydrolase 28 family
KM547_11955	COG0402	S-adenosylhomocysteine deaminase activity
KM547_11960	COG3548	integral membrane protein
KM547_11970	COG1509	lysine 2,3-aminomutase activity
KM547_12005	COG1862	Preprotein translocase
KM547_12015	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KM547_12025	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM547_12035	COG2755	lipolytic protein G-D-S-L family
KM547_12035	COG0657	acetylesterase activity
KM547_12040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KM547_12045	COG3291	Pkd domain containing protein
KM547_12050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM547_12080	COG0644	oxidoreductase
KM547_12100	COG0405	Gamma-glutamyltransferase
KM547_12105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KM547_12120	COG0742	ribosomal rna small subunit methyltransferase
KM547_12150	COG4771	TonB-dependent receptor
KM547_12205	COG0531	amino acid
KM547_12220	COG0006	proline dipeptidase activity
KM547_12230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KM547_12245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM547_12250	COG3938	Belongs to the proline racemase family
KM547_12260	COG0552	protein localization to endoplasmic reticulum
KM547_12265	COG1194	a g-specific adenine glycosylase
KM547_12310	COG0835	chemotaxis
KM547_12315	COG0840	transmembrane signaling receptor activity
KM547_12320	COG0840	transmembrane signaling receptor activity
KM547_12325	COG1201	RNA secondary structure unwinding
KM547_12335	COG3300	MHYT domain
KM547_12335	COG5001	Diguanylate cyclase
KM547_12345	COG1185	polyribonucleotide nucleotidyltransferase activity
KM547_12355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KM547_12370	COG0195	Participates in both transcription termination and antitermination
KM547_12385	COG1007	ATP synthesis coupled electron transport
KM547_12420	COG1034	ATP synthesis coupled electron transport
KM547_12425	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KM547_12430	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KM547_12435	COG0649	NAD binding
KM547_12440	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM547_12450	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM547_12480	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KM547_12540	COG2890	protein-(glutamine-N5) methyltransferase activity
KM547_12550	COG0688	phosphatidylethanolamine metabolic process
KM547_12565	COG0741	lytic transglycosylase activity
KM547_12570	COG0433	COG0433 Predicted ATPase
KM547_12575	COG0494	nUDIX hydrolase
KM547_12590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KM547_12615	COG0717	Belongs to the dCTP deaminase family
KM547_12620	COG0489	protein tyrosine kinase activity
KM547_12635	COG4771	TonB-dependent receptor
KM547_12645	COG4771	TonB-dependent receptor
KM547_12650	COG0457	Tetratricopeptide repeat
KM547_12660	COG3590	peptidase
KM547_12670	COG0705	Rhomboid family
KM547_12695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM547_12700	COG2311	Membrane
KM547_12705	COG1047	Peptidyl-prolyl cis-trans
KM547_12710	COG0791	NLP P60 protein
KM547_12715	COG0791	NLP P60 protein
KM547_12720	COG1607	acyl-coa hydrolase
KM547_12730	COG1301	dicarboxylic acid transport
KM547_12735	COG1785	Belongs to the alkaline phosphatase family
KM547_12750	COG1722	exodeoxyribonuclease VII activity
KM547_12755	COG0142	geranyltranstransferase activity
KM547_12765	COG4104	PAAR repeat-containing protein
KM547_12780	COG0312	modulator of DNA gyrase
KM547_12790	COG0312	modulator of DNA gyrase
KM547_12810	COG2968	Membrane
KM547_12825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KM547_12840	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KM547_12855	COG0495	leucyl-tRNA aminoacylation
KM547_12865	COG3118	belongs to the thioredoxin family
KM547_12880	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KM547_12890	COG2040	homocysteine
KM547_12900	COG0346	lactoylglutathione lyase activity
KM547_12925	COG2878	Part of a membrane complex involved in electron transport
KM547_12940	COG1595	DNA-templated transcription, initiation
KM547_12965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KM547_12990	COG0251	oxidation-reduction process
KM547_13000	COG0392	lysyltransferase activity
KM547_13000	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KM547_13030	COG2814	Major facilitator Superfamily
KM547_13035	COG1902	pentaerythritol trinitrate reductase activity
KM547_13040	COG0583	DNA-binding transcription factor activity
KM547_13055	COG2824	Alkylphosphonate utilization operon protein PhnA
KM547_13060	COG1047	Peptidyl-prolyl cis-trans
KM547_13065	COG1077	Cell shape determining protein MreB Mrl
KM547_13085	COG3287	FIST C domain
KM547_13085	COG2199	diguanylate cyclase activity
KM547_13085	COG2200	EAL domain
KM547_13100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KM547_13110	COG1451	nucleotide metabolic process
KM547_13135	COG0784	Response regulator, receiver
KM547_13135	COG2198	Histidine kinase
KM547_13135	COG2205	protein histidine kinase activity
KM547_13145	COG2186	Transcriptional regulator
KM547_13150	COG3250	beta-galactosidase activity
KM547_13195	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KM547_13195	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KM547_13195	COG1703	isobutyryl-CoA mutase activity
KM547_13220	COG0183	Belongs to the thiolase family
KM547_13260	COG1793	dna ligase
KM547_13260	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KM547_13265	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KM547_13265	COG1793	dna ligase
KM547_13270	COG1201	RNA secondary structure unwinding
KM547_13285	COG1278	Cold shock
KM547_13290	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KM547_13295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KM547_13300	COG1472	Belongs to the glycosyl hydrolase 3 family
KM547_13310	COG2954	triphosphatase activity
KM547_13320	COG2204	response regulator
KM547_13325	COG1381	Involved in DNA repair and RecF pathway recombination
KM547_13330	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KM547_13345	COG0681	Belongs to the peptidase S26 family
KM547_13350	COG0481	GTPase activity
KM547_13355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM547_13370	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM547_13370	COG1024	Enoyl-CoA hydratase
KM547_13385	COG2855	membrane
KM547_13400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KM547_13430	COG0534	Mate efflux family protein
KM547_13435	COG0335	large ribosomal subunit rRNA binding
KM547_13445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KM547_13450	COG0228	four-way junction DNA binding
KM547_13460	COG2070	2-Nitropropane dioxygenase
KM547_13465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KM547_13485	COG0475	glutathione-regulated potassium exporter activity
KM547_13495	COG0625	glutathione transferase activity
KM547_13500	COG1082	Xylose isomerase domain protein TIM barrel
KM547_13510	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM547_13515	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM547_13520	COG1129	ABC transporter
KM547_13525	COG1879	ABC-type sugar transport system periplasmic component
KM547_13530	COG1012	belongs to the aldehyde dehydrogenase family
KM547_13545	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_13550	COG0129	dihydroxy-acid dehydratase activity
KM547_13575	COG2207	Transcriptional regulator
KM547_13620	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM547_13645	COG4794	Type iii secretion
KM547_13675	COG0745	RESPONSE REGULATOR receiver
KM547_13725	COG3152	Membrane
KM547_13735	COG0156	8-amino-7-oxononanoate synthase activity
KM547_13745	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KM547_13750	COG1845	cytochrome c oxidase, subunit III
KM547_13755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KM547_13765	COG0750	zinc metalloprotease
KM547_13790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KM547_13805	COG0196	riboflavin kinase activity
KM547_13835	COG2801	Transposase and inactivated derivatives
KM547_13850	COG0728	peptidoglycan biosynthetic process
KM547_13870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KM547_13875	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KM547_13880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM547_13885	COG0824	Thioesterase
KM547_13900	COG1024	Enoyl-CoA hydratase
KM547_13905	COG1946	Acyl-CoA thioesterase
KM547_13920	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KM547_13960	COG1073	alpha beta
KM547_13985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KM547_14035	COG1643	Atp-dependent helicase
KM547_14040	COG0783	Belongs to the Dps family
KM547_14045	COG0514	ATP-dependent DNA helicase (RecQ)
KM547_14070	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KM547_14075	COG0602	queuosine metabolic process
KM547_14085	COG2885	chlorophyll binding
KM547_14100	COG0848	biopolymer transport protein
KM547_14110	COG0824	Thioesterase
KM547_14120	COG3158	transport of potassium into the cell
KM547_14125	COG0632	four-way junction helicase activity
KM547_14135	COG0217	transcriptional regulatory protein
KM547_14220	COG0488	(ABC) transporter
KM547_14275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM547_14275	COG4651	solute:proton antiporter activity
KM547_14285	COG4772	TonB-dependent receptor
KM547_14295	COG4264	IucA IucC family
KM547_14300	COG2814	Major facilitator Superfamily
KM547_14305	COG4264	IucA IucC family
KM547_14310	COG0019	diaminopimelate decarboxylase activity
KM547_14340	COG0542	response to heat
KM547_14365	COG0454	-acetyltransferase
KM547_14385	COG1877	trehalose-phosphatase activity
KM547_14390	COG3387	PFAM Glycoside hydrolase 15-related
KM547_14400	COG4993	Dehydrogenase
KM547_14405	COG0840	transmembrane signaling receptor activity
KM547_14415	COG0564	pseudouridine synthase activity
KM547_14420	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KM547_14430	COG1125	glycine betaine transport
KM547_14435	COG1174	glycine betaine transport
KM547_14450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KM547_14460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KM547_14460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KM547_14490	COG3657	addiction module killer protein
KM547_14495	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KM547_14530	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KM547_14545	COG0745	RESPONSE REGULATOR receiver
KM547_14555	COG0189	ligase activity
KM547_14565	COG3511	phospholipase C
KM547_14585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KM547_14600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KM547_14610	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KM547_14615	COG0174	glutamine synthetase
KM547_14645	COG2022	thiamine diphosphate biosynthetic process
KM547_14655	COG3273	potassium ion transport
KM547_14655	COG0471	metal ion transport
KM547_14670	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM547_14685	COG1609	Transcriptional regulator
KM547_14695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM547_14720	COG1115	amino acid carrier protein
KM547_14740	COG0438	transferase activity, transferring glycosyl groups
KM547_14745	COG0840	transmembrane signaling receptor activity
KM547_14750	COG0529	Catalyzes the synthesis of activated sulfate
KM547_14750	COG2895	sulfate adenylyltransferase (ATP) activity
KM547_14760	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KM547_14765	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM547_14770	COG0175	sulfate reduction
KM547_14800	COG1393	Belongs to the ArsC family
KM547_14810	COG2198	Histidine kinase
KM547_14810	COG0784	Response regulator, receiver
KM547_14810	COG2205	protein histidine kinase activity
KM547_14830	COG1648	precorrin-2 dehydrogenase activity
KM547_14830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KM547_14855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KM547_14865	COG2351	hydroxyisourate hydrolase activity
KM547_14870	COG2072	flavoprotein involved in K transport
KM547_14890	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KM547_14935	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KM547_14940	COG3588	fructose-bisphosphate aldolase
KM547_14945	COG0469	pyruvate kinase activity
KM547_14990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM547_14995	COG3047	cAMP biosynthetic process
KM547_15020	COG0640	Transcriptional regulator
KM547_15030	COG0725	ABC transporter, periplasmic molybdate-binding protein
KM547_15035	COG4149	molybdate abc transporter
KM547_15040	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KM547_15080	COG1376	ErfK ybiS ycfS ynhG family protein
KM547_15085	COG0739	heme binding
KM547_15110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KM547_15115	COG1301	dicarboxylic acid transport
KM547_15145	COG0714	Associated with various cellular activities
KM547_15175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KM547_15190	COG0372	Belongs to the citrate synthase family
KM547_15195	COG0254	rRNA binding
KM547_15205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KM547_15230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KM547_15235	COG1758	RNA polymerase activity
KM547_15240	COG0194	GDP metabolic process
KM547_15245	COG1561	YicC-like family, N-terminal region
KM547_15250	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KM547_15255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KM547_15260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM547_15280	COG0006	proline dipeptidase activity
KM547_15285	COG3079	Belongs to the UPF0149 family
KM547_15310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KM547_15320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KM547_15335	COG1773	rubredoxin
KM547_15350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KM547_15360	COG2010	Cytochrome c
KM547_15370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM547_15380	COG1940	carbohydrate kinase activity
KM547_15395	COG0671	phosphoesterase, PA-phosphatase related
KM547_15405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KM547_15415	COG0563	adenylate kinase activity
KM547_15435	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KM547_15445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KM547_15470	COG0840	transmembrane signaling receptor activity
KM547_15495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KM547_15515	COG0066	3-isopropylmalate dehydratase activity
KM547_15520	COG0473	3-isopropylmalate dehydrogenase activity
KM547_15525	COG3706	GGDEF domain
KM547_15535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KM547_15540	COG1538	Outer membrane efflux protein
KM547_15545	COG1519	Transferase
KM547_15550	COG1560	Kdo2-lipid A biosynthetic process
KM547_15630	COG0280	phosphate acetyltransferase
KM547_15630	COG0281	malic enzyme
KM547_15635	COG1301	dicarboxylic acid transport
KM547_15645	COG4191	Histidine kinase
KM547_15680	COG0642	Histidine kinase
KM547_15695	COG2851	Citrate transporter
KM547_15700	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_15755	COG1162	GTPase activity
KM547_15805	COG0436	Aminotransferase
KM547_15830	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KM547_15845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KM547_15850	COG1228	amidohydrolase
KM547_15865	COG1307	EDD domain protein, DegV family
KM547_15875	COG0697	spore germination
KM547_15885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM547_15895	COG3791	Glutathione-dependent formaldehyde-activating
KM547_15900	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KM547_15915	COG2205	protein histidine kinase activity
KM547_15955	COG2207	Transcriptional regulator
KM547_15980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KM547_16010	COG0617	tRNA 3'-terminal CCA addition
KM547_16065	COG0739	heme binding
KM547_16075	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KM547_16080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KM547_16090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KM547_16095	COG1181	Belongs to the D-alanine--D-alanine ligase family
KM547_16120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KM547_16135	COG3116	cell division
KM547_16140	COG0275	rRNA processing
KM547_16145	COG2001	Belongs to the MraZ family
KM547_16175	COG0792	nuclease activity
KM547_16180	COG1988	membrane-bound metal-dependent
KM547_16185	COG0277	FAD linked oxidase domain protein
KM547_16190	COG0745	RESPONSE REGULATOR receiver
KM547_16195	COG2205	protein histidine kinase activity
KM547_16205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KM547_16210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KM547_16235	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KM547_16240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KM547_16245	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KM547_16260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM547_16260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM547_16270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KM547_16300	COG0488	(ABC) transporter
KM547_16305	COG0242	peptide deformylase activity
KM547_16350	COG1215	transferase activity, transferring glycosyl groups
KM547_16360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM547_16410	COG2188	Transcriptional regulator
KM547_16420	COG1450	Type ii and iii secretion system protein
KM547_16435	COG3166	PFAM Fimbrial assembly family protein
KM547_16440	COG3156	type II secretion system protein K
KM547_16445	COG4795	General secretion pathway protein
KM547_16450	COG2165	general secretion pathway protein
KM547_16455	COG4970	Tfp pilus assembly protein FimT
KM547_16460	COG2165	general secretion pathway protein
KM547_16465	COG1459	type II secretion system
KM547_16470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KM547_16475	COG1404	Belongs to the peptidase S8 family
KM547_16480	COG5295	Hep Hag repeat protein
KM547_16485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KM547_16485	COG0047	phosphoribosylformylglycinamidine synthase activity
KM547_16490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KM547_16495	COG4974	Belongs to the 'phage' integrase family
KM547_16520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KM547_16530	COG0525	valine-tRNA ligase activity
KM547_16550	COG1183	phosphatidylcholine synthase activity
KM547_16560	COG0442	prolyl-tRNA aminoacylation
KM547_16575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KM547_16580	COG1127	ABC transporter
KM547_16585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KM547_16585	COG3218	ABC-type transport auxiliary lipoprotein component
KM547_16615	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KM547_16620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KM547_16625	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KM547_16625	COG0662	Cupin 2, conserved barrel domain protein
KM547_16650	COG2086	electron transfer activity
KM547_16665	COG0546	phosphoglycolate phosphatase activity
KM547_16665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KM547_16670	COG0277	FAD linked oxidase domain protein
KM547_16675	COG0300	oxidoreductase activity
KM547_16680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM547_16695	COG0493	'glutamate synthase
KM547_16725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KM547_16735	COG0438	transferase activity, transferring glycosyl groups
KM547_16735	COG1216	Glycosyl transferase, family 2
KM547_16740	COG0438	transferase activity, transferring glycosyl groups
KM547_16740	COG1216	Glycosyl transferase, family 2
KM547_16745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KM547_16760	COG0626	cystathionine gamma-synthase activity
KM547_16790	COG0625	glutathione transferase activity
KM547_16800	COG0513	Belongs to the DEAD box helicase family
KM547_16805	COG0720	synthase
KM547_16815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KM547_16820	COG1956	GAF domain-containing protein
KM547_16830	COG4206	TonB-dependent receptor
KM547_16835	COG0546	phosphoglycolate phosphatase activity
KM547_16860	COG0339	signal peptide processing
KM547_16865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM547_16875	COG2217	Heavy metal translocating P-type atpase
KM547_16890	COG2132	Multicopper oxidase
KM547_16910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KM547_16920	COG1136	(ABC) transporter
KM547_16935	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KM547_16950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KM547_16965	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KM547_16975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KM547_16985	COG0356	it plays a direct role in the translocation of protons across the membrane
KM547_17000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM547_17005	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM547_17040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM547_17045	COG0697	spore germination
KM547_17050	COG1666	GTP binding
KM547_17060	COG1187	pseudouridine synthase activity
KM547_17065	COG2813	Specifically methylates the guanine in position
KM547_17085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM547_17085	COG2205	protein histidine kinase activity
KM547_17110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM547_17190	COG0842	Transport permease protein
KM547_17195	COG1131	(ABC) transporter
KM547_17200	COG0025	NhaP-type Na H and K H
KM547_17210	COG1573	uracil-dna glycosylase
KM547_17220	COG3384	dioxygenase
KM547_17245	COG0667	Aldo Keto reductase
KM547_17255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM547_17280	COG3706	GGDEF domain
KM547_17290	COG5001	Diguanylate cyclase
KM547_17320	COG4106	trans-aconitate 2-methyltransferase activity
KM547_17330	COG2076	Multidrug Resistance protein
KM547_17340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KM547_17375	COG0531	amino acid
KM547_17385	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KM547_17385	COG5297	Belongs to the glycosyl hydrolase family 6
KM547_17390	COG0612	Peptidase, M16
KM547_17400	COG0741	lytic transglycosylase activity
KM547_17415	COG2207	Transcriptional regulator
KM547_17425	COG0598	Magnesium transport protein CorA
KM547_17430	COG1113	amino acid transport
KM547_17440	COG0697	spore germination
KM547_17450	COG0583	DNA-binding transcription factor activity
KM547_17470	COG2267	carboxylic ester hydrolase activity
KM547_17565	COG0464	growth
KM547_17575	COG0840	transmembrane signaling receptor activity
KM547_17615	COG2353	YceI-like domain
KM547_17645	COG0584	glycerophosphoryl diester phosphodiesterase
KM547_17660	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KM547_17680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KM547_17685	COG0459	protein refolding
KM547_17700	COG1324	tolerance protein
KM547_17710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM547_17720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KM547_17725	COG0511	ligase activity, forming carbon-carbon bonds
KM547_17730	COG0439	Biotin carboxylase
KM547_17745	COG2264	protein methyltransferase activity
KM547_17765	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KM547_17805	COG2267	carboxylic ester hydrolase activity
KM547_17810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KM547_17815	COG0138	bifunctional purine biosynthesis protein purh
KM547_17820	COG0151	Belongs to the GarS family
KM547_17825	COG1289	transmembrane transporter activity
KM547_17830	COG2814	Major facilitator Superfamily
KM547_17865	COG2816	NAD+ diphosphatase activity
KM547_17905	COG2906	2 iron, 2 sulfur cluster binding
KM547_17935	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
KM547_17950	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM547_17955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM547_17960	COG0730	response to heat
KM547_17965	COG4124	Belongs to the glycosyl hydrolase 26 family
KM547_17965	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KM547_17975	COG0134	indole-3-glycerol-phosphate synthase activity
KM547_17980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KM547_18000	COG1597	lipid kinase activity
KM547_18015	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KM547_18035	COG3179	chitinase
KM547_18045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM547_18050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM547_18050	COG2111	Na H antiporter
KM547_18055	COG1006	Multisubunit Na H antiporter MnhC subunit
KM547_18060	COG0651	ATP synthesis coupled electron transport
KM547_18070	COG2212	antiporter activity
KM547_18075	COG1320	monovalent cation:proton antiporter activity
KM547_18080	COG0530	calcium, potassium:sodium antiporter activity
KM547_18095	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KM547_18120	COG3104	oligopeptide transport
KM547_18135	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM547_18160	COG3227	Zinc metalloprotease (Elastase)
KM547_18165	COG0513	Belongs to the DEAD box helicase family
KM547_18180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM547_18185	COG1285	pathogenesis
KM547_18205	COG2354	Protein conserved in bacteria
KM547_18225	COG1196	nuclear chromosome segregation
KM547_18225	COG3264	Mechanosensitive ion channel
KM547_18230	COG3321	synthase
KM547_18230	COG0604	alcohol dehydrogenase
KM547_18230	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_18250	COG1595	DNA-templated transcription, initiation
KM547_18265	COG1802	Transcriptional regulator
KM547_18280	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
KM547_18315	COG1414	Transcriptional regulator
KM547_18320	COG0738	Major facilitator superfamily
KM547_18325	COG3254	rhamnose metabolic process
KM547_18335	COG4948	Mandelate Racemase Muconate Lactonizing
KM547_18340	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM547_18345	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_18360	COG0546	phosphoglycolate phosphatase activity
KM547_18375	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KM547_18390	COG4807	Protein conserved in bacteria
KM547_18400	COG1418	mRNA catabolic process
KM547_18415	COG0708	Exodeoxyribonuclease III
KM547_18445	COG4773	Receptor
KM547_18470	COG3800	Transcriptional regulator
KM547_18470	COG1396	sequence-specific DNA binding
KM547_18490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KM547_18495	COG1074	ATP-dependent DNA helicase activity
KM547_18500	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KM547_18505	COG1127	ABC transporter
KM547_18510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KM547_18515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KM547_18530	COG2853	Lipoprotein
KM547_18545	COG0386	Belongs to the glutathione peroxidase family
KM547_18550	COG1322	Protein conserved in bacteria
KM547_18565	COG1285	pathogenesis
KM547_18570	COG4191	Histidine kinase
KM547_18575	COG4566	intracellular signal transduction
KM547_18580	COG0531	amino acid
KM547_18590	COG1929	Belongs to the glycerate kinase type-1 family
KM547_18655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM547_18675	COG0628	permease
KM547_18680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KM547_18685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KM547_18695	COG0753	catalase activity
KM547_18705	COG2197	response regulator
KM547_18710	COG4585	Histidine kinase
KM547_18720	COG1131	(ABC) transporter
KM547_18730	COG1136	(ABC) transporter
KM547_18735	COG0577	efflux transmembrane transporter activity
KM547_18750	COG2962	Rard protein
KM547_18755	COG0697	spore germination
KM547_18770	COG0180	Tryptophanyl-tRNA synthetase
KM547_18780	COG3237	CsbD-like
KM547_18810	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KM547_18815	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KM547_18815	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KM547_18825	COG3228	Belongs to the MtfA family
KM547_18855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM547_18880	COG2084	Dehydrogenase
KM547_18885	COG1902	pentaerythritol trinitrate reductase activity
KM547_18895	COG2814	Major facilitator Superfamily
KM547_18900	COG0583	DNA-binding transcription factor activity
KM547_18920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KM547_18925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KM547_18930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KM547_18935	COG1764	response to oxidative stress
KM547_18940	COG1846	Transcriptional regulator
KM547_18950	COG1028	Short-chain dehydrogenase reductase Sdr
KM547_18960	COG0463	Glycosyl transferase, family 2
KM547_18970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KM547_18975	COG3100	YcgL domain-containing protein
KM547_19005	COG3387	PFAM Glycoside hydrolase 15-related
KM547_19010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM547_19030	COG1278	Cold shock
KM547_19045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KM547_19050	COG1960	acyl-CoA dehydrogenase activity
KM547_19060	COG3245	cytochrome
KM547_19070	COG1742	UPF0060 membrane protein
KM547_19085	COG0697	spore germination
KM547_19095	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KM547_19120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KM547_19135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM547_19155	COG1294	oxidase, subunit
KM547_19160	COG1271	oxidase subunit
KM547_19175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM547_19180	COG0408	coproporphyrinogen oxidase activity
KM547_19190	COG2323	membrane
KM547_19195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM547_19195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM547_19210	COG0589	response to stress
KM547_19225	COG0210	DNA helicase
KM547_19290	COG0463	Glycosyl transferase, family 2
KM547_19300	COG1475	DNA binding
KM547_19305	COG1192	Involved in chromosome partitioning
KM547_19310	COG0357	Ribosomal RNA small subunit methyltransferase G
KM547_19315	COG2091	lysine biosynthetic process via aminoadipic acid
KM547_19340	COG0477	Major facilitator Superfamily
KM547_19370	COG1971	Probably functions as a manganese efflux pump
KM547_19375	COG2205	protein histidine kinase activity
KM547_19380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM547_19385	COG3459	Glycosyltransferase 36 associated
KM547_19390	COG2211	Major facilitator Superfamily
KM547_19395	COG3265	gluconokinase activity
KM547_19420	COG2911	Protein conserved in bacteria
KM547_19425	COG0729	surface antigen
KM547_19445	COG3132	Protein of unknown function, DUF480
KM547_19485	COG0284	orotidine-5'-phosphate decarboxylase activity
KM547_19500	COG1609	Transcriptional regulator
KM547_19510	COG2937	Belongs to the GPAT DAPAT family
KM547_19535	COG2211	Major facilitator Superfamily
KM547_19550	COG3693	PFAM glycoside hydrolase, family 10
KM547_19555	COG1904	glucuronate isomerase
KM547_19590	COG0246	Mannitol dehydrogenase
KM547_19595	COG1472	Belongs to the glycosyl hydrolase 3 family
KM547_19605	COG4948	Mandelate Racemase Muconate Lactonizing
KM547_19615	COG3661	Belongs to the glycosyl hydrolase 67 family
KM547_19625	COG2115	Belongs to the xylose isomerase family
KM547_19630	COG0037	tRNA processing
KM547_19650	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM547_19660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KM547_19670	COG0805	protein transport
KM547_19680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KM547_19680	COG0519	Catalyzes the synthesis of GMP from XMP
KM547_19685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KM547_19700	COG0210	DNA helicase
KM547_19705	COG1435	thymidine kinase activity
KM547_19715	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
KM547_19725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KM547_19750	COG0706	membrane insertase activity
KM547_19755	COG0594	ribonuclease P activity