locus-tag	class	description
K8O61_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K8O61_00020	COG0187	DNA topoisomerase II activity
K8O61_00025	COG1266	CAAX protease self-immunity
K8O61_00030	COG0501	Belongs to the peptidase M48B family
K8O61_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8O61_00095	COG4772	TonB-dependent receptor
K8O61_00105	COG3284	Transcriptional regulator
K8O61_00115	COG1012	belongs to the aldehyde dehydrogenase family
K8O61_00150	COG1304	FMN binding
K8O61_00155	COG2186	Transcriptional regulator
K8O61_00225	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K8O61_00245	COG4771	TonB-dependent receptor
K8O61_00300	COG3186	Phenylalanine-4-hydroxylase
K8O61_00305	COG1522	sequence-specific DNA binding
K8O61_00310	COG1752	Esterase of the alpha-beta hydrolase superfamily
K8O61_00325	COG0671	phosphoesterase, PA-phosphatase related
K8O61_00340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K8O61_00375	COG1929	Belongs to the glycerate kinase type-1 family
K8O61_00385	COG0531	amino acid
K8O61_00390	COG4566	intracellular signal transduction
K8O61_00395	COG4191	Histidine kinase
K8O61_00400	COG1285	pathogenesis
K8O61_00415	COG1322	Protein conserved in bacteria
K8O61_00420	COG0386	Belongs to the glutathione peroxidase family
K8O61_00425	COG2853	Lipoprotein
K8O61_00440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K8O61_00445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K8O61_00450	COG1127	ABC transporter
K8O61_00460	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K8O61_00465	COG1074	ATP-dependent DNA helicase activity
K8O61_00470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K8O61_00560	COG0840	transmembrane signaling receptor activity
K8O61_00565	COG0477	Major facilitator Superfamily
K8O61_00570	COG0302	gtp cyclohydrolase
K8O61_00575	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K8O61_00605	COG0730	response to heat
K8O61_00620	COG2951	lytic endotransglycosylase activity
K8O61_00675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K8O61_00690	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K8O61_00695	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K8O61_00700	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K8O61_00720	COG0493	'glutamate synthase
K8O61_00725	COG0067	glutamate synthase
K8O61_00725	COG0069	glutamate synthase activity
K8O61_00725	COG0070	glutamate synthase
K8O61_00770	COG1111	helicase
K8O61_00770	COG1205	dead DEAH box helicase
K8O61_00810	COG2271	Major facilitator Superfamily
K8O61_00860	COG1192	Involved in chromosome partitioning
K8O61_00865	COG2062	phosphohistidine phosphatase, SixA
K8O61_00875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8O61_00880	COG2050	protein possibly involved in aromatic compounds catabolism
K8O61_00890	COG2267	carboxylic ester hydrolase activity
K8O61_00905	COG1881	PFAM PEBP family protein
K8O61_00910	COG1968	undecaprenyl-diphosphatase activity
K8O61_00915	COG0174	glutamine synthetase
K8O61_00920	COG0347	Belongs to the P(II) protein family
K8O61_00925	COG0004	ammonium transporteR
K8O61_00930	COG3852	Histidine kinase
K8O61_00935	COG2204	response regulator
K8O61_00940	COG2032	superoxide dismutase activity
K8O61_00945	COG2032	superoxide dismutase activity
K8O61_00970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K8O61_00975	COG1960	acyl-CoA dehydrogenase activity
K8O61_00985	COG3245	cytochrome
K8O61_01010	COG0523	cobalamin synthesis protein
K8O61_01015	COG0697	spore germination
K8O61_01025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K8O61_01030	COG1846	Transcriptional regulator
K8O61_01035	COG1764	response to oxidative stress
K8O61_01045	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K8O61_01050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K8O61_01070	COG2814	Major facilitator Superfamily
K8O61_01075	COG1404	Belongs to the peptidase S8 family
K8O61_01100	COG1902	pentaerythritol trinitrate reductase activity
K8O61_01130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K8O61_01170	COG3228	Belongs to the MtfA family
K8O61_01180	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K8O61_01180	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K8O61_01185	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K8O61_01215	COG3237	CsbD-like
K8O61_01225	COG0180	Tryptophanyl-tRNA synthetase
K8O61_01255	COG0339	signal peptide processing
K8O61_01270	COG0583	DNA-binding transcription factor activity
K8O61_01275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K8O61_01280	COG2224	Isocitrate lyase
K8O61_01315	COG0659	secondary active sulfate transmembrane transporter activity
K8O61_01345	COG0596	Alpha beta hydrolase
K8O61_01350	COG2130	NADP-dependent
K8O61_01365	COG1187	pseudouridine synthase activity
K8O61_01375	COG1643	Atp-dependent helicase
K8O61_01380	COG0084	hydrolase, TatD family'
K8O61_01395	COG0842	Transport permease protein
K8O61_01400	COG1131	(ABC) transporter
K8O61_01405	COG0633	Ferredoxin
K8O61_01405	COG0543	2 iron, 2 sulfur cluster binding
K8O61_01415	COG1476	TRANSCRIPTIONal
K8O61_01425	COG4555	ABC transporter
K8O61_01445	COG0625	glutathione transferase activity
K8O61_01515	COG1199	ATP-dependent helicase activity
K8O61_01555	COG0628	permease
K8O61_01570	COG0129	dihydroxy-acid dehydratase activity
K8O61_01575	COG2133	pyrroloquinoline quinone binding
K8O61_01625	COG5463	Belongs to the UPF0441 family
K8O61_01630	COG0754	glutathionylspermidine amidase activity
K8O61_01640	COG0714	Associated with various cellular activities
K8O61_01685	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K8O61_01700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O61_01705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8O61_01715	COG2203	Gaf domain
K8O61_01715	COG2200	EAL domain
K8O61_01715	COG2199	diguanylate cyclase activity
K8O61_01770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K8O61_01775	COG1040	competence protein
K8O61_01780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K8O61_01810	COG0606	chelatase, subunit chli
K8O61_01815	COG2960	long-chain fatty acid transporting porin activity
K8O61_01840	COG1166	arginine decarboxylase activity
K8O61_01855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8O61_01860	COG1819	glycosyl
K8O61_01865	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K8O61_01865	COG2755	lipolytic protein G-D-S-L family
K8O61_01875	COG0583	DNA-binding transcription factor activity
K8O61_01890	COG4221	oxidoreductase activity
K8O61_01910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K8O61_01930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K8O61_01940	COG2814	Major facilitator Superfamily
K8O61_01955	COG0739	heme binding
K8O61_01960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K8O61_01990	COG1064	alcohol dehydrogenase
K8O61_01995	COG2234	aminopeptidase activity
K8O61_02005	COG4942	peptidase
K8O61_02010	COG0793	Belongs to the peptidase S41A family
K8O61_02050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K8O61_02055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K8O61_02060	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K8O61_02090	COG0109	protoheme IX farnesyltransferase activity
K8O61_02105	COG0358	DNA primase activity
K8O61_02110	COG1295	ribonuclease BN
K8O61_02125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K8O61_02130	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K8O61_02135	COG2308	Evidence 4 Homologs of previously reported genes of
K8O61_02150	COG2133	pyrroloquinoline quinone binding
K8O61_02180	COG0531	amino acid
K8O61_02200	COG4771	TonB-dependent receptor
K8O61_02245	COG5383	Protein conserved in bacteria
K8O61_02255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8O61_02260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8O61_02265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O61_02280	COG1652	LysM domain
K8O61_02290	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K8O61_02295	COG1518	maintenance of DNA repeat elements
K8O61_02350	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K8O61_02355	COG3118	belongs to the thioredoxin family
K8O61_02365	COG2884	Cell division ATP-binding protein ftsE
K8O61_02370	COG2177	Part of the ABC transporter FtsEX involved in
K8O61_02375	COG2201	protein-glutamate methylesterase activity
K8O61_02380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K8O61_02385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K8O61_02390	COG2860	membrane
K8O61_02395	COG1252	NADH dehydrogenase
K8O61_02405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K8O61_02415	COG0534	Mate efflux family protein
K8O61_02420	COG0616	signal peptide processing
K8O61_02430	COG1028	Short-chain dehydrogenase reductase Sdr
K8O61_02445	COG0009	L-threonylcarbamoyladenylate synthase
K8O61_02450	COG1754	DNA topoisomerase type I activity
K8O61_02450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K8O61_02455	COG1714	RDD family
K8O61_02470	COG0758	DNA mediated transformation
K8O61_02475	COG1652	LysM domain
K8O61_02480	COG0242	peptide deformylase activity
K8O61_02485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K8O61_02490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K8O61_02490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K8O61_02495	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K8O61_02545	COG1490	D-aminoacyl-tRNA deacylase activity
K8O61_02550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K8O61_02570	COG1609	Transcriptional regulator
K8O61_02580	COG0366	Alpha amylase catalytic
K8O61_02585	COG0366	Alpha amylase catalytic
K8O61_02665	COG1309	transcriptional regulator
K8O61_02700	COG0840	transmembrane signaling receptor activity
K8O61_02715	COG3546	catalase activity
K8O61_02720	COG3685	Protein conserved in bacteria
K8O61_02725	COG3685	Protein conserved in bacteria
K8O61_02730	COG1028	Short-chain dehydrogenase reductase Sdr
K8O61_02740	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
K8O61_02755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K8O61_02770	COG0028	Belongs to the TPP enzyme family
K8O61_02775	COG4191	Histidine kinase
K8O61_02780	COG2204	response regulator
K8O61_02805	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K8O61_02820	COG3645	SOS response
K8O61_02840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K8O61_02840	COG1648	precorrin-2 dehydrogenase activity
K8O61_02850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K8O61_02850	COG1116	anion transmembrane transporter activity
K8O61_02855	COG2223	nitrite transmembrane transporter activity
K8O61_02860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K8O61_02865	COG2146	nitrite reductase [NAD(P)H] activity
K8O61_02870	COG0243	molybdopterin cofactor binding
K8O61_02895	COG1640	4-alpha-glucanotransferase
K8O61_02900	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K8O61_02910	COG0297	glycogen (starch) synthase activity
K8O61_02920	COG2204	response regulator
K8O61_02945	COG0181	hydroxymethylbilane synthase activity
K8O61_02960	COG1733	regulation of RNA biosynthetic process
K8O61_02975	COG1505	serine-type exopeptidase activity
K8O61_02980	COG0436	Aminotransferase
K8O61_02990	COG2832	Protein of unknown function (DUF454)
K8O61_03045	COG2226	methyltransferase
K8O61_03055	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K8O61_03060	COG0308	aminopeptidase N
K8O61_03065	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8O61_03065	COG0596	Alpha beta hydrolase
K8O61_03080	COG3284	Transcriptional regulator
K8O61_03095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K8O61_03100	COG1077	Cell shape determining protein MreB Mrl
K8O61_03115	COG0768	penicillin binding
K8O61_03120	COG0772	Belongs to the SEDS family
K8O61_03130	COG5434	Belongs to the glycosyl hydrolase 28 family
K8O61_03135	COG2951	lytic endotransglycosylase activity
K8O61_03145	COG1686	Belongs to the peptidase S11 family
K8O61_03165	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K8O61_03190	COG1051	belongs to the nudix hydrolase family
K8O61_03190	COG1056	cytidyltransferase-related domain
K8O61_03210	COG1090	epimerase
K8O61_03220	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K8O61_03225	COG0673	inositol 2-dehydrogenase activity
K8O61_03230	COG2823	Periplasmic or secreted lipoprotein
K8O61_03240	COG2205	protein histidine kinase activity
K8O61_03240	COG2202	Pas domain
K8O61_03245	COG0784	Response regulator, receiver
K8O61_03250	COG4191	Histidine kinase
K8O61_03260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K8O61_03280	COG4305	rare lipoprotein A
K8O61_03295	COG3250	beta-galactosidase activity
K8O61_03310	COG2188	Transcriptional regulator
K8O61_03320	COG1609	Transcriptional regulator
K8O61_03325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K8O61_03330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K8O61_03345	COG0617	tRNA 3'-terminal CCA addition
K8O61_03390	COG2207	Transcriptional regulator
K8O61_03415	COG2205	protein histidine kinase activity
K8O61_03430	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K8O61_03435	COG3791	Glutathione-dependent formaldehyde-activating
K8O61_03445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8O61_03455	COG0697	spore germination
K8O61_03500	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K8O61_03525	COG0436	Aminotransferase
K8O61_03530	COG1162	GTPase activity
K8O61_03555	COG2211	Major facilitator Superfamily
K8O61_03565	COG1028	Short-chain dehydrogenase reductase Sdr
K8O61_03570	COG2851	Citrate transporter
K8O61_03585	COG0642	Histidine kinase
K8O61_03615	COG1301	dicarboxylic acid transport
K8O61_03620	COG0281	malic enzyme
K8O61_03620	COG0280	phosphate acetyltransferase
K8O61_03635	COG1132	(ABC) transporter
K8O61_03660	COG1560	Kdo2-lipid A biosynthetic process
K8O61_03665	COG1519	Transferase
K8O61_03670	COG1538	Outer membrane efflux protein
K8O61_03675	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K8O61_03685	COG3706	GGDEF domain
K8O61_03690	COG0473	3-isopropylmalate dehydrogenase activity
K8O61_03695	COG0066	3-isopropylmalate dehydratase activity
K8O61_03715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K8O61_03740	COG0840	transmembrane signaling receptor activity
K8O61_03765	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K8O61_03775	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K8O61_03800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K8O61_03810	COG0671	phosphoesterase, PA-phosphatase related
K8O61_03825	COG1940	carbohydrate kinase activity
K8O61_03835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K8O61_03850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K8O61_03860	COG1773	rubredoxin
K8O61_03875	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K8O61_03885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K8O61_03910	COG3079	Belongs to the UPF0149 family
K8O61_03915	COG0006	proline dipeptidase activity
K8O61_03925	COG3038	cytochrome b561
K8O61_03930	COG1309	transcriptional regulator
K8O61_03935	COG0006	proline dipeptidase activity
K8O61_03950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K8O61_03955	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K8O61_03960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K8O61_03965	COG1561	YicC-like family, N-terminal region
K8O61_03970	COG0194	GDP metabolic process
K8O61_03975	COG1758	RNA polymerase activity
K8O61_03980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K8O61_04000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K8O61_04010	COG0254	rRNA binding
K8O61_04015	COG0372	Belongs to the citrate synthase family
K8O61_04030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K8O61_04060	COG0714	Associated with various cellular activities
K8O61_04090	COG1301	dicarboxylic acid transport
K8O61_04095	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K8O61_04120	COG0739	heme binding
K8O61_04125	COG1376	ErfK ybiS ycfS ynhG family protein
K8O61_04165	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K8O61_04170	COG4149	molybdate abc transporter
K8O61_04175	COG0725	ABC transporter, periplasmic molybdate-binding protein
K8O61_04185	COG0640	Transcriptional regulator
K8O61_04200	COG3047	cAMP biosynthetic process
K8O61_04205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K8O61_04250	COG0469	pyruvate kinase activity
K8O61_04255	COG3588	fructose-bisphosphate aldolase
K8O61_04265	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K8O61_04300	COG1648	precorrin-2 dehydrogenase activity
K8O61_04300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K8O61_04315	COG2205	protein histidine kinase activity
K8O61_04315	COG2198	Histidine kinase
K8O61_04315	COG0784	Response regulator, receiver
K8O61_04320	COG1393	Belongs to the ArsC family
K8O61_04350	COG0175	sulfate reduction
K8O61_04355	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K8O61_04360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K8O61_04370	COG2895	sulfate adenylyltransferase (ATP) activity
K8O61_04370	COG0529	Catalyzes the synthesis of activated sulfate
K8O61_04385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K8O61_04405	COG1609	Transcriptional regulator
K8O61_04420	COG0179	Fumarylacetoacetate (FAA) hydrolase
K8O61_04435	COG3273	potassium ion transport
K8O61_04435	COG0471	metal ion transport
K8O61_04445	COG2022	thiamine diphosphate biosynthetic process
K8O61_04465	COG0174	glutamine synthetase
K8O61_04470	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K8O61_04480	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K8O61_04495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K8O61_04520	COG1028	Short-chain dehydrogenase reductase Sdr
K8O61_04525	COG3511	phospholipase C
K8O61_04535	COG0189	ligase activity
K8O61_04545	COG0745	RESPONSE REGULATOR receiver
K8O61_04560	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K8O61_04600	COG0297	glycogen (starch) synthase activity
K8O61_04615	COG1216	Glycosyl transferase, family 2
K8O61_04670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K8O61_04670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K8O61_04680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K8O61_04695	COG1174	glycine betaine transport
K8O61_04700	COG1125	glycine betaine transport
K8O61_04710	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K8O61_04715	COG0564	pseudouridine synthase activity
K8O61_04740	COG4993	Dehydrogenase
K8O61_04750	COG3387	PFAM Glycoside hydrolase 15-related
K8O61_04775	COG0454	-acetyltransferase
K8O61_04795	COG0542	response to heat
K8O61_04815	COG0019	diaminopimelate decarboxylase activity
K8O61_04820	COG4264	IucA IucC family
K8O61_04825	COG2814	Major facilitator Superfamily
K8O61_04830	COG4264	IucA IucC family
K8O61_04840	COG4772	TonB-dependent receptor
K8O61_04850	COG4651	solute:proton antiporter activity
K8O61_04850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K8O61_04880	COG0488	(ABC) transporter
K8O61_04910	COG4774	siderophore transport
K8O61_04950	COG0217	transcriptional regulatory protein
K8O61_04960	COG0632	four-way junction helicase activity
K8O61_04965	COG3158	transport of potassium into the cell
K8O61_04970	COG2255	four-way junction helicase activity
K8O61_04975	COG0824	Thioesterase
K8O61_04985	COG0848	biopolymer transport protein
K8O61_05000	COG2885	chlorophyll binding
K8O61_05010	COG0602	queuosine metabolic process
K8O61_05015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K8O61_05035	COG0514	ATP-dependent DNA helicase (RecQ)
K8O61_05040	COG0783	Belongs to the Dps family
K8O61_05045	COG1643	Atp-dependent helicase
K8O61_05090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K8O61_05115	COG1073	alpha beta
K8O61_05140	COG4638	Rieske (2fe-2S)
K8O61_05155	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K8O61_05170	COG1946	Acyl-CoA thioesterase
K8O61_05175	COG1024	Enoyl-CoA hydratase
K8O61_05185	COG0824	Thioesterase
K8O61_05190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K8O61_05195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K8O61_05200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K8O61_05215	COG0728	peptidoglycan biosynthetic process
K8O61_05250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K8O61_05270	COG0750	zinc metalloprotease
K8O61_05285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K8O61_05290	COG1845	cytochrome c oxidase, subunit III
K8O61_05295	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K8O61_05315	COG3152	Membrane
K8O61_05340	COG0745	RESPONSE REGULATOR receiver
K8O61_05370	COG4794	Type iii secretion
K8O61_05395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K8O61_05420	COG1317	bacterial-type flagellum organization
K8O61_05440	COG2207	Transcriptional regulator
K8O61_05465	COG0129	dihydroxy-acid dehydratase activity
K8O61_05470	COG1028	Short-chain dehydrogenase reductase Sdr
K8O61_05485	COG1012	belongs to the aldehyde dehydrogenase family
K8O61_05490	COG1879	ABC-type sugar transport system periplasmic component
K8O61_05495	COG1129	ABC transporter
K8O61_05500	COG1172	Belongs to the binding-protein-dependent transport system permease family
K8O61_05505	COG1172	Belongs to the binding-protein-dependent transport system permease family
K8O61_05515	COG1082	Xylose isomerase domain protein TIM barrel
K8O61_05520	COG0625	glutathione transferase activity
K8O61_05540	COG0475	glutathione-regulated potassium exporter activity
K8O61_05565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K8O61_05585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K8O61_05595	COG0335	large ribosomal subunit rRNA binding
K8O61_05600	COG0534	Mate efflux family protein
K8O61_05625	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K8O61_05630	COG2894	cell division
K8O61_05635	COG0850	regulation of cytokinetic process
K8O61_05645	COG4585	Histidine kinase
K8O61_05665	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K8O61_05670	COG1216	Glycosyl transferase, family 2
K8O61_05675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K8O61_05685	COG1199	ATP-dependent helicase activity
K8O61_05705	COG0189	ligase activity
K8O61_05720	COG0835	chemotaxis
K8O61_05725	COG0840	transmembrane signaling receptor activity
K8O61_05730	COG0643	Histidine kinase
K8O61_05730	COG0784	Response regulator, receiver
K8O61_05730	COG2198	Histidine kinase
K8O61_05735	COG2201	protein-glutamate methylesterase activity
K8O61_05750	COG3209	COG3209 Rhs family protein
K8O61_05755	COG1446	asparaginase
K8O61_05760	COG3142	Participates in the control of copper homeostasis
K8O61_05855	COG3537	Alpha-1,2-mannosidase
K8O61_05875	COG1472	Belongs to the glycosyl hydrolase 3 family
K8O61_05885	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K8O61_05890	COG3858	chitin binding
K8O61_05890	COG1388	LysM domain
K8O61_05905	COG0837	glucose binding
K8O61_05915	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K8O61_05925	COG0494	nUDIX hydrolase
K8O61_05930	COG1218	3'(2'),5'-bisphosphate nucleotidase
K8O61_05935	COG3956	TIGRFAM MazG family protein
K8O61_05940	COG1742	UPF0060 membrane protein
K8O61_05945	COG0330	HflC and HflK could
K8O61_06010	COG2124	cytochrome p450
K8O61_06015	COG2124	cytochrome p450
K8O61_06020	COG1141	Ferredoxin
K8O61_06025	COG1028	Short-chain dehydrogenase reductase Sdr
K8O61_06030	COG2124	cytochrome p450
K8O61_06035	COG0142	geranyltranstransferase activity
K8O61_06040	COG1657	PFAM Prenyltransferase squalene oxidase
K8O61_06050	COG1304	FMN binding
K8O61_06055	COG1960	acyl-CoA dehydrogenase activity
K8O61_06090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K8O61_06095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K8O61_06100	COG0463	Glycosyl transferase, family 2
K8O61_06105	COG0517	IMP dehydrogenase activity
K8O61_06110	COG2982	Protein involved in outer membrane biogenesis
K8O61_06115	COG1272	protein, Hemolysin III
K8O61_06120	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K8O61_06135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K8O61_06140	COG0626	cystathionine gamma-synthase activity
K8O61_06145	COG0527	aspartate kinase activity
K8O61_06145	COG0460	homoserine dehydrogenase
K8O61_06160	COG1760	l-serine dehydratase
K8O61_06175	COG3038	cytochrome b561
K8O61_06195	COG2814	Major facilitator Superfamily
K8O61_06200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K8O61_06210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O61_06215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8O61_06255	COG0789	Transcriptional regulator
K8O61_06275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K8O61_06290	COG0519	Catalyzes the synthesis of GMP from XMP
K8O61_06305	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K8O61_06325	COG0840	transmembrane signaling receptor activity
K8O61_06335	COG1113	amino acid transport
K8O61_06355	COG2239	Acts as a magnesium transporter
K8O61_06360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K8O61_06365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8O61_06375	COG1660	Displays ATPase and GTPase activities
K8O61_06385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8O61_06400	COG1137	ATPase activity
K8O61_06415	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K8O61_06460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K8O61_06480	COG0628	permease
K8O61_06490	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K8O61_06495	COG3178	'Phosphotransferase
K8O61_06510	COG1555	photosystem II stabilization
K8O61_06535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K8O61_06540	COG1477	protein flavinylation
K8O61_06565	COG4774	siderophore transport
K8O61_06570	COG2146	nitrite reductase [NAD(P)H] activity
K8O61_06580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K8O61_06585	COG0719	Fe-S assembly protein
K8O61_06590	COG0396	ATPase activity
K8O61_06595	COG0719	Fe-S assembly protein
K8O61_06610	COG0693	protein deglycase activity
K8O61_06625	COG0739	heme binding
K8O61_06640	COG1764	response to oxidative stress
K8O61_06650	COG0384	phenazine biosynthesis protein PhzF
K8O61_06655	COG0527	aspartate kinase activity
K8O61_06670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K8O61_06680	COG0142	geranyltranstransferase activity
K8O61_06685	COG0629	single-stranded DNA binding
K8O61_06700	COG1297	OPT oligopeptide transporter protein
K8O61_06705	COG0823	Involved in the tonB-independent uptake of proteins
K8O61_06705	COG1506	peptidase
K8O61_06720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K8O61_06725	COG2879	small protein
K8O61_06730	COG1966	Carbon starvation protein
K8O61_06775	COG1515	deoxyribonuclease V activity
K8O61_06810	COG5001	Diguanylate cyclase
K8O61_06810	COG3706	GGDEF domain
K8O61_06810	COG2203	Gaf domain
K8O61_06810	COG4251	negative regulation of phosphorylation
K8O61_06815	COG0835	chemotaxis
K8O61_06820	COG0840	transmembrane signaling receptor activity
K8O61_06825	COG0840	transmembrane signaling receptor activity
K8O61_06835	COG0643	Histidine kinase
K8O61_06835	COG2198	Histidine kinase
K8O61_06845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K8O61_06865	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K8O61_06910	COG0735	belongs to the Fur family
K8O61_06980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K8O61_07050	COG1187	pseudouridine synthase activity
K8O61_07075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K8O61_07160	COG1981	membrane
K8O61_07170	COG0825	malonyl-CoA metabolic process
K8O61_07185	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8O61_07190	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8O61_07205	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K8O61_07210	COG0750	zinc metalloprotease
K8O61_07215	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K8O61_07220	COG0575	Belongs to the CDS family
K8O61_07225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K8O61_07235	COG0528	UMP kinase activity
K8O61_07245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K8O61_07285	COG0024	Methionine aminopeptidase
K8O61_07300	COG1393	Belongs to the ArsC family
K8O61_07305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K8O61_07315	COG0367	asparagine synthase
K8O61_07350	COG1566	PFAM secretion protein HlyD family protein
K8O61_07355	COG2814	Major facilitator Superfamily
K8O61_07395	COG0557	exoribonuclease II activity
K8O61_07405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K8O61_07430	COG0704	Plays a role in the regulation of phosphate uptake
K8O61_07440	COG0581	inorganic phosphate transmembrane transporter activity
K8O61_07455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K8O61_07475	COG0659	secondary active sulfate transmembrane transporter activity
K8O61_07480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K8O61_07490	COG1024	Enoyl-CoA hydratase
K8O61_07535	COG0116	Belongs to the methyltransferase superfamily
K8O61_07535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K8O61_07545	COG0784	Response regulator, receiver
K8O61_07545	COG2205	protein histidine kinase activity
K8O61_07545	COG5002	protein histidine kinase activity
K8O61_07550	COG2733	membrane
K8O61_07570	COG0686	Belongs to the AlaDH PNT family
K8O61_07575	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K8O61_07580	COG1917	Cupin 2, conserved barrel domain protein
K8O61_07580	COG1396	sequence-specific DNA binding
K8O61_07585	COG1012	belongs to the aldehyde dehydrogenase family
K8O61_07610	COG2223	nitrite transmembrane transporter activity
K8O61_07620	COG0243	molybdopterin cofactor binding
K8O61_07640	COG0477	Major facilitator Superfamily
K8O61_07650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8O61_07655	COG0174	glutamine synthetase
K8O61_07660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K8O61_07665	COG0174	glutamine synthetase
K8O61_07675	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K8O61_07680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K8O61_07700	COG3842	ATPase activity
K8O61_07705	COG1176	ABC-type spermidine putrescine transport system, permease component I
K8O61_07710	COG1177	transmembrane transport
K8O61_07715	COG1012	belongs to the aldehyde dehydrogenase family
K8O61_07730	COG4535	Mg2 and Co2 transporter CorC
K8O61_07745	COG1702	phosphate starvation-inducible protein PhoH
K8O61_07760	COG0741	lytic transglycosylase activity
K8O61_07765	COG0723	plastoquinol--plastocyanin reductase activity
K8O61_07770	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K8O61_07780	COG2857	Cytochrome c1
K8O61_07785	COG0625	glutathione transferase activity
K8O61_07790	COG2969	positive regulation of protein catabolic process
K8O61_07805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O61_07855	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K8O61_07860	COG1028	Short-chain dehydrogenase reductase Sdr
K8O61_07865	COG2095	MarC family integral membrane protein
K8O61_07875	COG1611	Belongs to the LOG family
K8O61_07880	COG3275	phosphorelay sensor kinase activity
K8O61_07965	COG0556	nucleotide-excision repair
K8O61_08005	COG1741	Belongs to the pirin family
K8O61_08010	COG0583	DNA-binding transcription factor activity
K8O61_08030	COG0351	phosphomethylpyrimidine kinase
K8O61_08045	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K8O61_08050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K8O61_08060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K8O61_08070	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K8O61_08075	COG3734	2-keto-3-deoxy-galactonokinase
K8O61_08090	COG0800	Aldolase
K8O61_08105	COG1070	Carbohydrate kinase
K8O61_08110	COG2115	Belongs to the xylose isomerase family
K8O61_08115	COG0477	Major facilitator Superfamily
K8O61_08125	COG0860	N-Acetylmuramoyl-L-alanine amidase
K8O61_08145	COG0617	tRNA 3'-terminal CCA addition
K8O61_08155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K8O61_08170	COG0166	Belongs to the GPI family
K8O61_08295	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K8O61_08310	COG0671	phosphoesterase, PA-phosphatase related
K8O61_08335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K8O61_08340	COG0167	dihydroorotate dehydrogenase activity
K8O61_08355	COG1012	belongs to the aldehyde dehydrogenase family
K8O61_08370	COG0460	homoserine dehydrogenase
K8O61_08370	COG0527	aspartate kinase activity
K8O61_08380	COG2951	lytic endotransglycosylase activity
K8O61_08390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K8O61_08400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K8O61_08405	COG0124	histidyl-tRNA synthetase
K8O61_08415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K8O61_08420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K8O61_08425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K8O61_08435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K8O61_08450	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K8O61_08450	COG0140	phosphoribosyl-ATP diphosphatase activity
K8O61_08465	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
K8O61_08470	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K8O61_08475	COG0235	Class ii aldolase
K8O61_08480	COG0531	amino acid
K8O61_08485	COG0531	amino acid
K8O61_08500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K8O61_08505	COG0277	FAD linked oxidase domain protein
K8O61_08525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K8O61_08545	COG1024	Enoyl-CoA hydratase
K8O61_08565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8O61_08570	COG2258	MOSC domain
K8O61_08575	COG0084	hydrolase, TatD family'
K8O61_08590	COG1960	acyl-CoA dehydrogenase activity
K8O61_08600	COG0305	Participates in initiation and elongation during chromosome replication
K8O61_08605	COG0415	Belongs to the DNA photolyase family
K8O61_08620	COG0583	DNA-binding transcription factor activity
K8O61_08635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O61_08775	COG1404	Belongs to the peptidase S8 family
K8O61_08780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K8O61_08785	COG2867	negative regulation of translational initiation
K8O61_08795	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K8O61_08800	COG0735	belongs to the Fur family
K8O61_08805	COG0497	DNA recombination
K8O61_08810	COG1420	regulation of RNA biosynthetic process
K8O61_08815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K8O61_08820	COG0443	Heat shock 70 kDa protein
K8O61_08825	COG0484	heat shock protein binding
K8O61_08830	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K8O61_08835	COG0287	Prephenate dehydrogenase
K8O61_08835	COG1605	Chorismate mutase
K8O61_08845	COG1132	(ABC) transporter
K8O61_08870	COG2826	transposase and inactivated derivatives, IS30 family
K8O61_08885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K8O61_08910	COG2850	peptidyl-arginine hydroxylation
K8O61_08950	COG1131	(ABC) transporter
K8O61_08955	COG1725	Transcriptional regulator
K8O61_08965	COG0386	Belongs to the glutathione peroxidase family
K8O61_08980	COG2900	Belongs to the SlyX family
K8O61_08990	COG2755	lipolytic protein G-D-S-L family
K8O61_08990	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K8O61_09000	COG0646	methionine synthase
K8O61_09000	COG1410	methionine synthase
K8O61_09005	COG1410	methionine synthase
K8O61_09005	COG0646	methionine synthase
K8O61_09010	COG2226	methyltransferase
K8O61_09015	COG1960	acyl-CoA dehydrogenase activity
K8O61_09020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8O61_09025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O61_09035	COG2902	Dehydrogenase
K8O61_09075	COG2925	Exonuclease
K8O61_09085	COG3844	kynureninase activity
K8O61_09095	COG0662	Cupin 2, conserved barrel domain protein
K8O61_09100	COG0288	reversible hydration of carbon dioxide
K8O61_09145	COG2197	response regulator
K8O61_09170	COG0316	Belongs to the HesB IscA family
K8O61_09210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K8O61_09215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K8O61_09225	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K8O61_09260	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K8O61_09290	COG4221	oxidoreductase activity
K8O61_09330	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K8O61_09335	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K8O61_09340	COG0077	Prephenate dehydratase
K8O61_09340	COG1605	Chorismate mutase
K8O61_09380	COG1530	ribonuclease E activity
K8O61_09390	COG3064	Membrane
K8O61_09395	COG0428	transporter
K8O61_09410	COG0316	Belongs to the HesB IscA family
K8O61_09410	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K8O61_09450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K8O61_09455	COG2957	Belongs to the agmatine deiminase family
K8O61_09465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K8O61_09470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K8O61_09475	COG0539	negative regulation of cytoplasmic translation
K8O61_09480	COG0776	regulation of translation
K8O61_09490	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K8O61_09495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K8O61_09505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K8O61_09510	COG0183	Belongs to the thiolase family
K8O61_09515	COG1024	Enoyl-CoA hydratase
K8O61_09515	COG1250	3-hydroxyacyl-CoA dehydrogenase
K8O61_09530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K8O61_09540	COG1426	Protein conserved in bacteria
K8O61_09550	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K8O61_09570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K8O61_09575	COG0475	glutathione-regulated potassium exporter activity
K8O61_09575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K8O61_09580	COG4773	Receptor
K8O61_09610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K8O61_09635	COG1501	Belongs to the glycosyl hydrolase 31 family
K8O61_09640	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
K8O61_09650	COG1914	H( )-stimulated, divalent metal cation uptake system
K8O61_09665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K8O61_09670	COG0668	transmembrane transport
K8O61_09695	COG1028	Short-chain dehydrogenase reductase Sdr
K8O61_09700	COG1183	phosphatidylcholine synthase activity
K8O61_09710	COG3243	poly(R)-hydroxyalkanoic acid synthase
K8O61_09730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8O61_09730	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K8O61_09740	COG0784	Response regulator, receiver
K8O61_09740	COG4191	Histidine kinase
K8O61_09745	COG2183	response to ionizing radiation
K8O61_09750	COG0784	Response regulator, receiver
K8O61_09750	COG2205	protein histidine kinase activity
K8O61_09820	COG1649	PFAM Uncharacterised BCR, COG1649
K8O61_09840	COG0512	Glutamine amidotransferase of anthranilate synthase
K8O61_09860	COG1132	(ABC) transporter
K8O61_09880	COG0438	transferase activity, transferring glycosyl groups
K8O61_09885	COG0297	glycogen (starch) synthase activity
K8O61_09890	COG2264	protein methyltransferase activity
K8O61_09915	COG1215	transferase activity, transferring glycosyl groups
K8O61_09920	COG2244	polysaccharide biosynthetic process
K8O61_09950	COG3038	cytochrome b561
K8O61_09970	COG1595	DNA-templated transcription, initiation
K8O61_10025	COG0038	chloride channel
K8O61_10030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K8O61_10050	COG1674	ftsk spoiiie
K8O61_10055	COG0492	ferredoxin-NADP+ reductase activity
K8O61_10075	COG0542	response to heat
K8O61_10095	COG0482	sulfurtransferase activity
K8O61_10100	COG2915	High frequency lysogenization protein hflD homolog
K8O61_10115	COG1116	anion transmembrane transporter activity
K8O61_10160	COG0784	Response regulator, receiver
K8O61_10160	COG0835	chemotaxis
K8O61_10170	COG1558	bacterial-type flagellum-dependent cell motility
K8O61_10180	COG1749	Flagellar hook protein flgE
K8O61_10195	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K8O61_10210	COG1256	bacterial-type flagellum assembly
K8O61_10210	COG4786	Flagellar basal body rod
K8O61_10210	COG4786	Flagellar basal body rod
K8O61_10210	COG1256	bacterial-type flagellum assembly
K8O61_10215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K8O61_10220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K8O61_10225	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K8O61_10245	COG2197	response regulator
K8O61_10250	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K8O61_10255	COG2201	protein-glutamate methylesterase activity
K8O61_10275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8O61_10280	COG1028	Short-chain dehydrogenase reductase Sdr
K8O61_10325	COG1677	Flagellar hook-basal body complex protein FliE
K8O61_10375	COG3190	flagellar
K8O61_10385	COG1987	bacterial-type flagellum assembly
K8O61_10390	COG1684	flagellar biosynthetic protein fliR
K8O61_10435	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K8O61_10440	COG2198	Histidine kinase
K8O61_10440	COG0784	Response regulator, receiver
K8O61_10440	COG0643	Histidine kinase
K8O61_10445	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K8O61_10450	COG1360	Flagellar Motor Protein
K8O61_10460	COG0835	chemotaxis
K8O61_10470	COG0745	RESPONSE REGULATOR receiver
K8O61_10485	COG0840	transmembrane signaling receptor activity
K8O61_10490	COG0840	transmembrane signaling receptor activity
K8O61_10495	COG0840	transmembrane signaling receptor activity
K8O61_10500	COG0840	transmembrane signaling receptor activity
K8O61_10510	COG0840	transmembrane signaling receptor activity
K8O61_10525	COG0840	transmembrane signaling receptor activity
K8O61_10530	COG0840	transmembrane signaling receptor activity
K8O61_10540	COG0840	transmembrane signaling receptor activity
K8O61_10550	COG0835	chemotaxis
K8O61_10560	COG0840	transmembrane signaling receptor activity
K8O61_10575	COG0840	transmembrane signaling receptor activity
K8O61_10635	COG0318	PFAM AMP-dependent synthetase and ligase
K8O61_10640	COG1024	Enoyl-CoA hydratase
K8O61_10645	COG2198	Histidine kinase
K8O61_10645	COG2205	protein histidine kinase activity
K8O61_10645	COG0784	Response regulator, receiver
K8O61_10710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K8O61_10715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K8O61_10725	COG0505	Belongs to the CarA family
K8O61_10740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K8O61_10805	COG0386	Belongs to the glutathione peroxidase family
K8O61_10825	COG1846	Transcriptional regulator
K8O61_10870	COG1472	Belongs to the glycosyl hydrolase 3 family
K8O61_10880	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K8O61_10895	COG0488	(ABC) transporter
K8O61_10900	COG0513	Belongs to the DEAD box helicase family
K8O61_10905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K8O61_10930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K8O61_10935	COG0657	acetylesterase activity
K8O61_10940	COG0625	glutathione transferase activity
K8O61_10950	COG0564	pseudouridine synthase activity
K8O61_10955	COG4681	YaeQ
K8O61_10960	COG2081	HI0933 family
K8O61_10980	COG1028	Short-chain dehydrogenase reductase Sdr
K8O61_11000	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K8O61_11005	COG0860	N-Acetylmuramoyl-L-alanine amidase
K8O61_11010	COG0802	atpase or kinase
K8O61_11015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K8O61_11015	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K8O61_11020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K8O61_11025	COG1570	exodeoxyribonuclease VII activity
K8O61_11065	COG1960	acyl-CoA dehydrogenase activity
K8O61_11075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K8O61_11100	COG0438	transferase activity, transferring glycosyl groups
K8O61_11110	COG0438	transferase activity, transferring glycosyl groups
K8O61_11115	COG0438	transferase activity, transferring glycosyl groups
K8O61_11165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K8O61_11170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K8O61_11180	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K8O61_11215	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K8O61_11220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K8O61_11225	COG2137	regulation of response to DNA damage stimulus
K8O61_11230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K8O61_11235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K8O61_11240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K8O61_11245	COG1546	Belongs to the CinA family
K8O61_11250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K8O61_11265	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K8O61_11270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K8O61_11275	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K8O61_11280	COG1534	Rna-binding protein
K8O61_11295	COG1238	metal cluster binding
K8O61_11305	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K8O61_11320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K8O61_11325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K8O61_11330	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K8O61_11340	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K8O61_11345	COG0504	CTP synthase activity
K8O61_11365	COG0306	phosphate transporter
K8O61_11375	COG1253	flavin adenine dinucleotide binding
K8O61_11390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K8O61_11420	COG3447	MASE1 domain protein
K8O61_11420	COG5001	Diguanylate cyclase
K8O61_11420	COG5002	protein histidine kinase activity
K8O61_11435	COG0069	glutamate synthase activity
K8O61_11440	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K8O61_11450	COG1609	Transcriptional regulator
K8O61_11455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K8O61_11455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8O61_11460	COG1105	Belongs to the carbohydrate kinase PfkB family
K8O61_11465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K8O61_11465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K8O61_11495	COG1136	(ABC) transporter
K8O61_11495	COG0577	efflux transmembrane transporter activity
K8O61_11535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8O61_11545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K8O61_11550	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
K8O61_11560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K8O61_11570	COG0348	domain, Protein
K8O61_11690	COG3179	chitinase
K8O61_11885	COG3209	COG3209 Rhs family protein
K8O61_11910	COG5444	nuclease activity
K8O61_11925	COG3209	COG3209 Rhs family protein
K8O61_11945	COG3209	COG3209 Rhs family protein
K8O61_11970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K8O61_11985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K8O61_11995	COG1663	tetraacyldisaccharide 4'-kinase activity
K8O61_12000	COG1132	(ABC) transporter
K8O61_12010	COG0811	peptide transport
K8O61_12030	COG4591	ABC-type transport system involved in lipoprotein release permease component
K8O61_12045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K8O61_12055	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K8O61_12060	COG2009	succinate dehydrogenase
K8O61_12070	COG0354	folic acid binding
K8O61_12075	COG3842	ATPase activity
K8O61_12080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K8O61_12095	COG0129	dihydroxy-acid dehydratase activity
K8O61_12100	COG0800	Aldolase
K8O61_12110	COG0395	ABC-type sugar transport system, permease component
K8O61_12145	COG2350	Protein conserved in bacteria
K8O61_12150	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K8O61_12155	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K8O61_12160	COG1187	pseudouridine synthase activity
K8O61_12180	COG0436	Aminotransferase
K8O61_12185	COG4133	protoheme IX ABC transporter activity
K8O61_12230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K8O61_12235	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K8O61_12240	COG4988	ABC transporter
K8O61_12250	COG1294	oxidase, subunit
K8O61_12285	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K8O61_12305	COG0165	Argininosuccinate lyase
K8O61_12310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K8O61_12320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K8O61_12325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K8O61_12330	COG0137	argininosuccinate synthase activity
K8O61_12335	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K8O61_12350	COG2166	iron-sulfur cluster assembly
K8O61_12380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K8O61_12390	COG4677	pectinesterase activity
K8O61_12415	COG0402	S-adenosylhomocysteine deaminase activity
K8O61_12420	COG3548	integral membrane protein
K8O61_12430	COG1509	lysine 2,3-aminomutase activity
K8O61_12435	COG3706	GGDEF domain
K8O61_12435	COG4251	negative regulation of phosphorylation
K8O61_12435	COG5001	Diguanylate cyclase
K8O61_12435	COG2203	Gaf domain
K8O61_12465	COG1862	Preprotein translocase
K8O61_12475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K8O61_12485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K8O61_12500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K8O61_12505	COG3291	Pkd domain containing protein
K8O61_12510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8O61_12515	COG0405	Gamma-glutamyltransferase
K8O61_12520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K8O61_12535	COG0742	ribosomal rna small subunit methyltransferase
K8O61_12570	COG4771	TonB-dependent receptor
K8O61_12615	COG0531	amino acid
K8O61_12630	COG0006	proline dipeptidase activity
K8O61_12640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K8O61_12655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8O61_12660	COG3938	Belongs to the proline racemase family
K8O61_12670	COG0552	protein localization to endoplasmic reticulum
K8O61_12720	COG0835	chemotaxis
K8O61_12725	COG0840	transmembrane signaling receptor activity
K8O61_12730	COG0840	transmembrane signaling receptor activity
K8O61_12750	COG3300	MHYT domain
K8O61_12750	COG5001	Diguanylate cyclase
K8O61_12755	COG1185	polyribonucleotide nucleotidyltransferase activity
K8O61_12780	COG0195	Participates in both transcription termination and antitermination
K8O61_12795	COG1007	ATP synthesis coupled electron transport
K8O61_12830	COG1034	ATP synthesis coupled electron transport
K8O61_12835	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K8O61_12840	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K8O61_12845	COG0649	NAD binding
K8O61_12850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8O61_12860	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8O61_12890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K8O61_12930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K8O61_12945	COG2890	protein-(glutamine-N5) methyltransferase activity
K8O61_12955	COG0688	phosphatidylethanolamine metabolic process
K8O61_12965	COG0433	COG0433 Predicted ATPase
K8O61_12975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K8O61_13000	COG0717	Belongs to the dCTP deaminase family
K8O61_13005	COG0489	protein tyrosine kinase activity
K8O61_13010	COG4771	TonB-dependent receptor
K8O61_13015	COG4771	TonB-dependent receptor
K8O61_13020	COG0457	Tetratricopeptide repeat
K8O61_13030	COG3590	peptidase
K8O61_13050	COG0697	spore germination
K8O61_13070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8O61_13075	COG2311	Membrane
K8O61_13080	COG1047	Peptidyl-prolyl cis-trans
K8O61_13085	COG0791	NLP P60 protein
K8O61_13090	COG0791	NLP P60 protein
K8O61_13105	COG1607	acyl-coa hydrolase
K8O61_13110	COG2226	methyltransferase
K8O61_13115	COG1301	dicarboxylic acid transport
K8O61_13120	COG1785	Belongs to the alkaline phosphatase family
K8O61_13130	COG0037	tRNA processing
K8O61_13135	COG1722	exodeoxyribonuclease VII activity
K8O61_13140	COG0142	geranyltranstransferase activity
K8O61_13145	COG4104	PAAR repeat-containing protein
K8O61_13155	COG1858	cytochrome C peroxidase
K8O61_13180	COG2815	serine threonine protein kinase
K8O61_13180	COG0515	serine threonine protein kinase
K8O61_13185	COG0631	protein serine/threonine phosphatase activity
K8O61_13280	COG0312	modulator of DNA gyrase
K8O61_13290	COG0312	modulator of DNA gyrase
K8O61_13310	COG2968	Membrane
K8O61_13325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K8O61_13340	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K8O61_13355	COG0495	leucyl-tRNA aminoacylation
K8O61_13365	COG3118	belongs to the thioredoxin family
K8O61_13380	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K8O61_13390	COG2040	homocysteine
K8O61_13400	COG0346	lactoylglutathione lyase activity
K8O61_13405	COG1131	(ABC) transporter
K8O61_13435	COG2878	Part of a membrane complex involved in electron transport
K8O61_13450	COG1595	DNA-templated transcription, initiation
K8O61_13475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K8O61_13495	COG0251	oxidation-reduction process
K8O61_13505	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K8O61_13505	COG0392	lysyltransferase activity
K8O61_13535	COG2814	Major facilitator Superfamily
K8O61_13540	COG1902	pentaerythritol trinitrate reductase activity
K8O61_13545	COG2824	Alkylphosphonate utilization operon protein PhnA
K8O61_13550	COG1047	Peptidyl-prolyl cis-trans
K8O61_13555	COG1077	Cell shape determining protein MreB Mrl
K8O61_13590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K8O61_13600	COG1451	nucleotide metabolic process
K8O61_13620	COG2205	protein histidine kinase activity
K8O61_13630	COG2186	Transcriptional regulator
K8O61_13635	COG3250	beta-galactosidase activity
K8O61_13680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K8O61_13680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K8O61_13680	COG1703	isobutyryl-CoA mutase activity
K8O61_13705	COG0183	Belongs to the thiolase family
K8O61_13750	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K8O61_13750	COG1793	dna ligase
K8O61_13755	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K8O61_13755	COG1793	dna ligase
K8O61_13760	COG1201	RNA secondary structure unwinding
K8O61_13770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K8O61_13775	COG1278	Cold shock
K8O61_13780	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K8O61_13785	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K8O61_13790	COG1472	Belongs to the glycosyl hydrolase 3 family
K8O61_13795	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K8O61_13800	COG2954	triphosphatase activity
K8O61_13810	COG0745	RESPONSE REGULATOR receiver
K8O61_13815	COG1381	Involved in DNA repair and RecF pathway recombination
K8O61_13820	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K8O61_13835	COG0681	Belongs to the peptidase S26 family
K8O61_13840	COG0481	GTPase activity
K8O61_13845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K8O61_13860	COG1250	3-hydroxyacyl-CoA dehydrogenase
K8O61_13860	COG1024	Enoyl-CoA hydratase
K8O61_13875	COG2855	membrane
K8O61_13890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K8O61_13910	COG2205	protein histidine kinase activity
K8O61_13915	COG0745	RESPONSE REGULATOR receiver
K8O61_13925	COG2194	sulfuric ester hydrolase activity
K8O61_13945	COG2814	Major facilitator Superfamily
K8O61_13970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K8O61_13970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K8O61_13975	COG0753	catalase activity
K8O61_14000	COG1063	alcohol dehydrogenase
K8O61_14010	COG3459	Glycosyltransferase 36 associated
K8O61_14080	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K8O61_14130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K8O61_14140	COG0330	HflC and HflK could
K8O61_14145	COG0330	HflC and HflK could
K8O61_14150	COG0604	alcohol dehydrogenase
K8O61_14170	COG0678	peroxiredoxin activity
K8O61_14180	COG4953	penicillin-binding protein 1C
K8O61_14200	COG2373	Large extracellular alpha-helical protein
K8O61_14230	COG3609	addiction module antidote protein, CC2985 family
K8O61_14255	COG0372	Belongs to the citrate synthase family
K8O61_14260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K8O61_14275	COG0587	DNA-directed DNA polymerase activity
K8O61_14315	COG2161	toxin-antitoxin pair type II binding
K8O61_14320	COG4115	mRNA cleavage
K8O61_14340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K8O61_14345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K8O61_14350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K8O61_14360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8O61_14365	COG1028	Short-chain dehydrogenase reductase Sdr
K8O61_14370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K8O61_14375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8O61_14380	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K8O61_14385	COG1399	metal-binding, possibly nucleic acid-binding protein
K8O61_14405	COG0714	Associated with various cellular activities
K8O61_14425	COG0537	adenosine 5'-monophosphoramidase activity
K8O61_14485	COG0210	DNA helicase
K8O61_14525	COG2003	Belongs to the UPF0758 family
K8O61_14595	COG2336	PFAM SpoVT AbrB
K8O61_14660	COG0314	molybdopterin synthase activity
K8O61_14665	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K8O61_14670	COG0315	cyclic pyranopterin monophosphate synthase activity
K8O61_14680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K8O61_14685	COG1234	tRNA 3'-trailer cleavage
K8O61_14695	COG0859	PFAM glycosyl transferase family 9
K8O61_14710	COG0631	protein serine/threonine phosphatase activity
K8O61_14720	COG0328	RNA-DNA hybrid ribonuclease activity
K8O61_14730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8O61_14735	COG3942	CHAP domain
K8O61_14735	COG1388	LysM domain
K8O61_14770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K8O61_14780	COG0544	peptidyl-prolyl cis-trans isomerase activity
K8O61_14815	COG0473	3-isopropylmalate dehydrogenase activity
K8O61_14830	COG4783	chaperone-mediated protein folding
K8O61_14845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K8O61_14850	COG0248	Ppx GppA phosphatase
K8O61_14855	COG0438	transferase activity, transferring glycosyl groups
K8O61_14865	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8O61_14880	COG2833	Protein of unknown function (DUF455)
K8O61_14900	COG0285	dihydrofolate synthase activity
K8O61_14905	COG0588	phosphoglycerate mutase activity
K8O61_14925	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K8O61_14930	COG4208	sulfate ABC transporter
K8O61_14935	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K8O61_14940	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
K8O61_14945	COG0156	8-amino-7-oxononanoate synthase activity
K8O61_14960	COG2885	chlorophyll binding
K8O61_14970	COG2814	Major facilitator Superfamily
K8O61_14980	COG0667	Aldo Keto reductase
K8O61_14995	COG1902	pentaerythritol trinitrate reductase activity
K8O61_14995	COG0446	pyridine nucleotide-disulphide oxidoreductase
K8O61_15020	COG0584	glycerophosphoryl diester phosphodiesterase
K8O61_15040	COG0625	glutathione transferase activity
K8O61_15055	COG0039	L-malate dehydrogenase activity
K8O61_15065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K8O61_15070	COG1217	gtp-binding protein TYPA
K8O61_15090	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K8O61_15100	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K8O61_15105	COG0203	ribosomal protein L17
K8O61_15115	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K8O61_15130	COG0201	protein transport
K8O61_15140	COG1841	ribosomal large subunit assembly
K8O61_15170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K8O61_15175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K8O61_15185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K8O61_15190	COG0255	Belongs to the universal ribosomal protein uL29 family
K8O61_15215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K8O61_15220	COG0089	rRNA binding
K8O61_15225	COG0088	Forms part of the polypeptide exit tunnel
K8O61_15235	COG0051	transcription antitermination factor activity, RNA binding
K8O61_15240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K8O61_15245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K8O61_15260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K8O61_15270	COG0222	ribosome binding
K8O61_15285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K8O61_15290	COG0250	Participates in transcription elongation, termination and antitermination
K8O61_15295	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K8O61_15305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K8O61_15325	COG0012	GTP binding
K8O61_15330	COG0193	aminoacyl-tRNA hydrolase activity
K8O61_15340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K8O61_15365	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K8O61_15370	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K8O61_15390	COG0521	Mo-molybdopterin cofactor biosynthetic process
K8O61_15410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8O61_15415	COG1295	ribonuclease BN
K8O61_15435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K8O61_15445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K8O61_15520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8O61_15520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8O61_15555	COG2890	protein-(glutamine-N5) methyltransferase activity
K8O61_15565	COG3634	alkyl hydroperoxide reductase activity
K8O61_15570	COG0583	DNA-binding transcription factor activity
K8O61_15580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K8O61_15590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K8O61_15620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K8O61_15625	COG0697	spore germination
K8O61_15650	COG0673	inositol 2-dehydrogenase activity
K8O61_15665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K8O61_15670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K8O61_15680	COG2096	Adenosyltransferase
K8O61_15695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K8O61_15700	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K8O61_15705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K8O61_15710	COG2967	ApaG domain
K8O61_15715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K8O61_15745	COG1704	LemA family
K8O61_15750	COG0861	Integral membrane protein TerC family
K8O61_15755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K8O61_15765	COG0642	Histidine kinase
K8O61_15780	COG4181	ATPase activity
K8O61_15785	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K8O61_15805	COG4771	TonB-dependent receptor
K8O61_15815	COG0667	Aldo Keto reductase
K8O61_15820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8O61_15835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K8O61_15860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K8O61_15900	COG2226	methyltransferase
K8O61_15925	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K8O61_15935	COG0494	nUDIX hydrolase
K8O61_15950	COG0739	heme binding
K8O61_15960	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K8O61_15965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K8O61_15975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K8O61_15980	COG1181	Belongs to the D-alanine--D-alanine ligase family
K8O61_15990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K8O61_16005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K8O61_16020	COG3116	cell division
K8O61_16025	COG0275	rRNA processing
K8O61_16030	COG2001	Belongs to the MraZ family
K8O61_16055	COG0792	nuclease activity
K8O61_16065	COG0277	FAD linked oxidase domain protein
K8O61_16070	COG0745	RESPONSE REGULATOR receiver
K8O61_16075	COG2205	protein histidine kinase activity
K8O61_16085	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K8O61_16090	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K8O61_16115	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K8O61_16120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K8O61_16125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K8O61_16140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K8O61_16140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K8O61_16150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K8O61_16170	COG0488	(ABC) transporter
K8O61_16175	COG0242	peptide deformylase activity
K8O61_16200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8O61_16210	COG1215	transferase activity, transferring glycosyl groups
K8O61_16220	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K8O61_16275	COG2188	Transcriptional regulator
K8O61_16285	COG1450	Type ii and iii secretion system protein
K8O61_16300	COG3166	PFAM Fimbrial assembly family protein
K8O61_16305	COG3156	type II secretion system protein K
K8O61_16310	COG4795	General secretion pathway protein
K8O61_16315	COG2165	general secretion pathway protein
K8O61_16320	COG4970	Tfp pilus assembly protein FimT
K8O61_16325	COG2165	general secretion pathway protein
K8O61_16330	COG1459	type II secretion system
K8O61_16335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K8O61_16340	COG1404	Belongs to the peptidase S8 family
K8O61_16345	COG5295	Hep Hag repeat protein
K8O61_16360	COG0047	phosphoribosylformylglycinamidine synthase activity
K8O61_16360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K8O61_16365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K8O61_16370	COG4974	Belongs to the 'phage' integrase family
K8O61_16395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K8O61_16400	COG2927	DNA polymerase III (CHI subunit)
K8O61_16430	COG1183	phosphatidylcholine synthase activity
K8O61_16440	COG0442	prolyl-tRNA aminoacylation
K8O61_16455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K8O61_16460	COG1127	ABC transporter
K8O61_16465	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K8O61_16465	COG3218	ABC-type transport auxiliary lipoprotein component
K8O61_16495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K8O61_16500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K8O61_16505	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K8O61_16505	COG0662	Cupin 2, conserved barrel domain protein
K8O61_16530	COG2086	electron transfer activity
K8O61_16545	COG0546	phosphoglycolate phosphatase activity
K8O61_16545	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K8O61_16550	COG0277	FAD linked oxidase domain protein
K8O61_16555	COG0300	oxidoreductase activity
K8O61_16560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8O61_16575	COG0493	'glutamate synthase
K8O61_16595	COG0438	transferase activity, transferring glycosyl groups
K8O61_16595	COG1216	Glycosyl transferase, family 2
K8O61_16610	COG1216	Glycosyl transferase, family 2
K8O61_16610	COG0438	transferase activity, transferring glycosyl groups
K8O61_16615	COG1216	Glycosyl transferase, family 2
K8O61_16615	COG0438	transferase activity, transferring glycosyl groups
K8O61_16620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K8O61_16635	COG0626	cystathionine gamma-synthase activity
K8O61_16665	COG0625	glutathione transferase activity
K8O61_16680	COG0720	synthase
K8O61_16690	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K8O61_16695	COG1956	GAF domain-containing protein
K8O61_16705	COG4206	TonB-dependent receptor
K8O61_16750	COG0339	signal peptide processing
K8O61_16755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K8O61_16765	COG2217	Heavy metal translocating P-type atpase
K8O61_16780	COG2132	Multicopper oxidase
K8O61_16800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K8O61_16825	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K8O61_16840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K8O61_16855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K8O61_16865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K8O61_16875	COG0356	it plays a direct role in the translocation of protons across the membrane
K8O61_16890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K8O61_16895	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8O61_16930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K8O61_16935	COG0697	spore germination
K8O61_16940	COG1666	GTP binding
K8O61_16950	COG1187	pseudouridine synthase activity
K8O61_16975	COG2205	protein histidine kinase activity
K8O61_16975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8O61_17000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8O61_17080	COG0842	Transport permease protein
K8O61_17085	COG1131	(ABC) transporter
K8O61_17090	COG0025	NhaP-type Na H and K H
K8O61_17100	COG1573	uracil-dna glycosylase
K8O61_17110	COG3384	dioxygenase
K8O61_17115	COG0583	DNA-binding transcription factor activity
K8O61_17125	COG0667	Aldo Keto reductase
K8O61_17135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8O61_17140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8O61_17165	COG3706	GGDEF domain
K8O61_17180	COG5001	Diguanylate cyclase
K8O61_17210	COG4106	trans-aconitate 2-methyltransferase activity
K8O61_17220	COG2076	Multidrug Resistance protein
K8O61_17230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K8O61_17265	COG3275	phosphorelay sensor kinase activity
K8O61_17270	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
K8O61_17290	COG0531	amino acid
K8O61_17300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K8O61_17300	COG5297	Belongs to the glycosyl hydrolase family 6
K8O61_17305	COG0612	Peptidase, M16
K8O61_17315	COG0741	lytic transglycosylase activity
K8O61_17330	COG2207	Transcriptional regulator
K8O61_17340	COG0598	Magnesium transport protein CorA
K8O61_17345	COG1113	amino acid transport
K8O61_17350	COG0697	spore germination
K8O61_17385	COG5520	Belongs to the glycosyl hydrolase 30 family
K8O61_17490	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K8O61_17510	COG0840	transmembrane signaling receptor activity
K8O61_17545	COG2353	YceI-like domain
K8O61_17575	COG0584	glycerophosphoryl diester phosphodiesterase
K8O61_17585	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K8O61_17605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K8O61_17610	COG0459	protein refolding
K8O61_17625	COG1324	tolerance protein
K8O61_17635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8O61_17645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K8O61_17650	COG0511	ligase activity, forming carbon-carbon bonds
K8O61_17655	COG0439	Biotin carboxylase
K8O61_17670	COG2264	protein methyltransferase activity
K8O61_17690	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K8O61_17710	COG0138	bifunctional purine biosynthesis protein purh
K8O61_17715	COG0151	Belongs to the GarS family
K8O61_17720	COG1289	transmembrane transporter activity
K8O61_17725	COG2814	Major facilitator Superfamily
K8O61_17760	COG2816	NAD+ diphosphatase activity
K8O61_17800	COG2906	2 iron, 2 sulfur cluster binding
K8O61_17830	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
K8O61_17845	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K8O61_17850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K8O61_17855	COG0730	response to heat
K8O61_17870	COG0134	indole-3-glycerol-phosphate synthase activity
K8O61_17875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K8O61_17895	COG1597	lipid kinase activity
K8O61_17910	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K8O61_17930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K8O61_17930	COG2111	Na H antiporter
K8O61_17935	COG1006	Multisubunit Na H antiporter MnhC subunit
K8O61_17940	COG0651	ATP synthesis coupled electron transport
K8O61_17950	COG2212	antiporter activity
K8O61_17955	COG1320	monovalent cation:proton antiporter activity
K8O61_17960	COG0530	calcium, potassium:sodium antiporter activity
K8O61_17975	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K8O61_17980	COG2852	Protein conserved in bacteria
K8O61_18005	COG3104	oligopeptide transport
K8O61_18010	COG3483	tryptophan 2,3-dioxygenase activity
K8O61_18020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K8O61_18035	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8O61_18050	COG0513	Belongs to the DEAD box helicase family
K8O61_18070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K8O61_18080	COG2354	Protein conserved in bacteria
K8O61_18095	COG3264	Mechanosensitive ion channel
K8O61_18095	COG1196	nuclear chromosome segregation
K8O61_18100	COG1028	Short-chain dehydrogenase reductase Sdr
K8O61_18100	COG3321	synthase
K8O61_18100	COG0604	alcohol dehydrogenase
K8O61_18120	COG1595	DNA-templated transcription, initiation
K8O61_18135	COG1802	Transcriptional regulator
K8O61_18185	COG1414	Transcriptional regulator
K8O61_18190	COG0738	Major facilitator superfamily
K8O61_18195	COG3254	rhamnose metabolic process
K8O61_18200	COG4948	Mandelate Racemase Muconate Lactonizing
K8O61_18205	COG0179	Fumarylacetoacetate (FAA) hydrolase
K8O61_18210	COG1028	Short-chain dehydrogenase reductase Sdr
K8O61_18240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K8O61_18255	COG4807	Protein conserved in bacteria
K8O61_18285	COG1506	peptidase
K8O61_18285	COG0823	Involved in the tonB-independent uptake of proteins
K8O61_18360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K8O61_18385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K8O61_18390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K8O61_18400	COG0753	catalase activity
K8O61_18420	COG1136	(ABC) transporter
K8O61_18425	COG0577	efflux transmembrane transporter activity
K8O61_18445	COG0697	spore germination
K8O61_18450	COG0564	pseudouridine synthase activity
K8O61_18470	COG1181	Belongs to the D-alanine--D-alanine ligase family
K8O61_18480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8O61_18495	COG0318	PFAM AMP-dependent synthetase and ligase
K8O61_18500	COG0727	PFAM Uncharacterised protein family (UPF0153)
K8O61_18510	COG0596	Alpha beta hydrolase
K8O61_18525	COG3177	Filamentation induced by cAMP protein fic
K8O61_18530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8O61_18540	COG0612	Peptidase, M16
K8O61_18550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K8O61_18560	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K8O61_18565	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K8O61_18600	COG0183	Belongs to the thiolase family
K8O61_18610	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K8O61_18615	COG3387	PFAM Glycoside hydrolase 15-related
K8O61_18620	COG0745	RESPONSE REGULATOR receiver
K8O61_18635	COG1404	Belongs to the peptidase S8 family
K8O61_18665	COG3100	YcgL domain-containing protein
K8O61_18670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K8O61_18680	COG0463	Glycosyl transferase, family 2
K8O61_18715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K8O61_18730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8O61_18770	COG1294	oxidase, subunit
K8O61_18775	COG1271	oxidase subunit
K8O61_18790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K8O61_18795	COG0408	coproporphyrinogen oxidase activity
K8O61_18805	COG2323	membrane
K8O61_18830	COG0589	response to stress
K8O61_18845	COG0210	DNA helicase
K8O61_18895	COG0463	Glycosyl transferase, family 2
K8O61_18910	COG1192	Involved in chromosome partitioning
K8O61_18915	COG0357	Ribosomal RNA small subunit methyltransferase G
K8O61_18920	COG3540	Alkaline phosphatase
K8O61_18925	COG2091	lysine biosynthetic process via aminoadipic acid
K8O61_18950	COG0477	Major facilitator Superfamily
K8O61_18970	COG1971	Probably functions as a manganese efflux pump
K8O61_18975	COG2205	protein histidine kinase activity
K8O61_18990	COG3459	Glycosyltransferase 36 associated
K8O61_18995	COG2211	Major facilitator Superfamily
K8O61_19000	COG3265	gluconokinase activity
K8O61_19020	COG2911	Protein conserved in bacteria
K8O61_19025	COG0729	surface antigen
K8O61_19050	COG3132	Protein of unknown function, DUF480
K8O61_19085	COG0284	orotidine-5'-phosphate decarboxylase activity
K8O61_19110	COG2937	Belongs to the GPAT DAPAT family
K8O61_19135	COG2211	Major facilitator Superfamily
K8O61_19145	COG3693	PFAM glycoside hydrolase, family 10
K8O61_19155	COG3386	PFAM SMP-30 Gluconolaconase
K8O61_19165	COG3046	protein related to deoxyribodipyrimidine photolyase
K8O61_19180	COG0246	Mannitol dehydrogenase
K8O61_19185	COG1472	Belongs to the glycosyl hydrolase 3 family
K8O61_19190	COG3507	Belongs to the glycosyl hydrolase 43 family
K8O61_19205	COG2115	Belongs to the xylose isomerase family
K8O61_19235	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K8O61_19245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K8O61_19255	COG0805	protein transport
K8O61_19265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K8O61_19265	COG0519	Catalyzes the synthesis of GMP from XMP
K8O61_19270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K8O61_19285	COG0210	DNA helicase
K8O61_19290	COG1435	thymidine kinase activity
K8O61_19300	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K8O61_19310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K8O61_19325	COG1119	ATPase activity
K8O61_19340	COG0706	membrane insertase activity
K8O61_19345	COG0594	ribonuclease P activity