locus-tag	class	description
KM539_00010	COG0592	DNA-directed DNA polymerase activity
KM539_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KM539_00020	COG0187	DNA topoisomerase II activity
KM539_00025	COG1266	CAAX protease self-immunity
KM539_00030	COG0501	Belongs to the peptidase M48B family
KM539_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM539_00100	COG1280	lysine exporter protein (LysE YggA)
KM539_00125	COG4772	TonB-dependent receptor
KM539_00140	COG3284	Transcriptional regulator
KM539_00145	COG1012	belongs to the aldehyde dehydrogenase family
KM539_00180	COG1304	FMN binding
KM539_00185	COG2186	Transcriptional regulator
KM539_00205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM539_00300	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KM539_00375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KM539_00390	COG3507	Belongs to the glycosyl hydrolase 43 family
KM539_00395	COG1609	Transcriptional regulator
KM539_00410	COG1028	Short-chain dehydrogenase reductase Sdr
KM539_00425	COG3186	Phenylalanine-4-hydroxylase
KM539_00430	COG1522	sequence-specific DNA binding
KM539_00445	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM539_00460	COG0671	phosphoesterase, PA-phosphatase related
KM539_00475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KM539_00505	COG1522	sequence-specific DNA binding
KM539_00510	COG4771	TonB-dependent receptor
KM539_00515	COG0531	amino acid
KM539_00520	COG0154	amidase activity
KM539_00525	COG1929	Belongs to the glycerate kinase type-1 family
KM539_00535	COG0531	amino acid
KM539_00540	COG4566	intracellular signal transduction
KM539_00545	COG4191	Histidine kinase
KM539_00550	COG1285	pathogenesis
KM539_00565	COG1322	Protein conserved in bacteria
KM539_00570	COG0386	Belongs to the glutathione peroxidase family
KM539_00580	COG2853	Lipoprotein
KM539_00595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KM539_00600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KM539_00605	COG1127	ABC transporter
KM539_00610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KM539_00615	COG1074	ATP-dependent DNA helicase activity
KM539_00620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KM539_00640	COG0537	adenosine 5'-monophosphoramidase activity
KM539_00650	COG0537	adenosine 5'-monophosphoramidase activity
KM539_00740	COG0477	Major facilitator Superfamily
KM539_00745	COG0302	gtp cyclohydrolase
KM539_00770	COG0730	response to heat
KM539_00785	COG3706	GGDEF domain
KM539_00790	COG2951	lytic endotransglycosylase activity
KM539_00810	COG3135	benzoate transporter
KM539_00840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM539_00845	COG1803	Methylglyoxal synthase
KM539_00850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KM539_00855	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KM539_00860	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KM539_00870	COG0493	'glutamate synthase
KM539_00875	COG0067	glutamate synthase
KM539_00875	COG0070	glutamate synthase
KM539_00875	COG0069	glutamate synthase activity
KM539_00920	COG1205	dead DEAH box helicase
KM539_00920	COG1111	helicase
KM539_00960	COG2271	Major facilitator Superfamily
KM539_01000	COG1192	Involved in chromosome partitioning
KM539_01005	COG2062	phosphohistidine phosphatase, SixA
KM539_01015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM539_01020	COG2050	protein possibly involved in aromatic compounds catabolism
KM539_01030	COG2267	carboxylic ester hydrolase activity
KM539_01045	COG1968	undecaprenyl-diphosphatase activity
KM539_01050	COG0174	glutamine synthetase
KM539_01055	COG0347	Belongs to the P(II) protein family
KM539_01060	COG0004	ammonium transporteR
KM539_01065	COG3852	Histidine kinase
KM539_01070	COG2204	response regulator
KM539_01075	COG2032	superoxide dismutase activity
KM539_01080	COG2032	superoxide dismutase activity
KM539_01090	COG0183	Belongs to the thiolase family
KM539_01130	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KM539_01135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KM539_01145	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KM539_01155	COG0612	Peptidase, M16
KM539_01165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM539_01170	COG3177	Filamentation induced by cAMP protein fic
KM539_01175	COG0596	Alpha beta hydrolase
KM539_01185	COG0727	PFAM Uncharacterised protein family (UPF0153)
KM539_01190	COG0318	PFAM AMP-dependent synthetase and ligase
KM539_01205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM539_01215	COG1181	Belongs to the D-alanine--D-alanine ligase family
KM539_01235	COG4232	protein-disulfide reductase activity
KM539_01240	COG0564	pseudouridine synthase activity
KM539_01260	COG0339	signal peptide processing
KM539_01265	COG0681	Belongs to the peptidase S26 family
KM539_01285	COG0583	DNA-binding transcription factor activity
KM539_01290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KM539_01295	COG2224	Isocitrate lyase
KM539_01300	COG3706	GGDEF domain
KM539_01330	COG0659	secondary active sulfate transmembrane transporter activity
KM539_01360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM539_01365	COG2130	NADP-dependent
KM539_01380	COG1187	pseudouridine synthase activity
KM539_01395	COG1643	Atp-dependent helicase
KM539_01400	COG0084	hydrolase, TatD family'
KM539_01410	COG1846	Transcriptional regulator
KM539_01415	COG1764	response to oxidative stress
KM539_01430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KM539_01435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KM539_01440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KM539_01450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM539_01460	COG0583	DNA-binding transcription factor activity
KM539_01465	COG2814	Major facilitator Superfamily
KM539_01480	COG1902	pentaerythritol trinitrate reductase activity
KM539_01485	COG2084	Dehydrogenase
KM539_01560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM539_01590	COG3228	Belongs to the MtfA family
KM539_01600	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KM539_01600	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KM539_01605	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KM539_01710	COG3237	CsbD-like
KM539_01720	COG0180	Tryptophanyl-tRNA synthetase
KM539_01740	COG0697	spore germination
KM539_01760	COG0577	efflux transmembrane transporter activity
KM539_01765	COG1136	(ABC) transporter
KM539_01775	COG1131	(ABC) transporter
KM539_01785	COG4585	Histidine kinase
KM539_01820	COG0753	catalase activity
KM539_01830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KM539_01835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KM539_01860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM539_01935	COG0412	Dienelactone hydrolase
KM539_01950	COG4773	Receptor
KM539_01960	COG1418	mRNA catabolic process
KM539_01970	COG4807	Protein conserved in bacteria
KM539_01985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KM539_02015	COG1028	Short-chain dehydrogenase reductase Sdr
KM539_02020	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM539_02025	COG4948	Mandelate Racemase Muconate Lactonizing
KM539_02030	COG3254	rhamnose metabolic process
KM539_02035	COG0738	Major facilitator superfamily
KM539_02040	COG1414	Transcriptional regulator
KM539_02075	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
KM539_02090	COG1802	Transcriptional regulator
KM539_02110	COG1595	DNA-templated transcription, initiation
KM539_02140	COG3321	synthase
KM539_02140	COG1028	Short-chain dehydrogenase reductase Sdr
KM539_02140	COG0604	alcohol dehydrogenase
KM539_02145	COG3264	Mechanosensitive ion channel
KM539_02145	COG1196	nuclear chromosome segregation
KM539_02175	COG2354	Protein conserved in bacteria
KM539_02185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM539_02205	COG0513	Belongs to the DEAD box helicase family
KM539_02210	COG3227	Zinc metalloprotease (Elastase)
KM539_02235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM539_02250	COG3104	oligopeptide transport
KM539_02270	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KM539_02285	COG0530	calcium, potassium:sodium antiporter activity
KM539_02290	COG1320	monovalent cation:proton antiporter activity
KM539_02295	COG2212	antiporter activity
KM539_02305	COG0651	ATP synthesis coupled electron transport
KM539_02310	COG1006	Multisubunit Na H antiporter MnhC subunit
KM539_02315	COG2111	Na H antiporter
KM539_02315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM539_02320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM539_02350	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KM539_02365	COG1597	lipid kinase activity
KM539_02410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KM539_02415	COG0134	indole-3-glycerol-phosphate synthase activity
KM539_02425	COG4124	Belongs to the glycosyl hydrolase 26 family
KM539_02425	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KM539_02430	COG0730	response to heat
KM539_02435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM539_02440	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM539_02455	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
KM539_02480	COG1051	belongs to the nudix hydrolase family
KM539_02485	COG2906	2 iron, 2 sulfur cluster binding
KM539_02530	COG2816	NAD+ diphosphatase activity
KM539_02570	COG2814	Major facilitator Superfamily
KM539_02575	COG1289	transmembrane transporter activity
KM539_02580	COG0151	Belongs to the GarS family
KM539_02585	COG0138	bifunctional purine biosynthesis protein purh
KM539_02590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KM539_02615	COG4589	Belongs to the CDS family
KM539_02620	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KM539_02640	COG2264	protein methyltransferase activity
KM539_02655	COG0439	Biotin carboxylase
KM539_02660	COG0511	ligase activity, forming carbon-carbon bonds
KM539_02665	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KM539_02675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM539_02685	COG1324	tolerance protein
KM539_02690	COG2356	endonuclease I
KM539_02700	COG0459	protein refolding
KM539_02705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KM539_02725	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KM539_02745	COG0584	glycerophosphoryl diester phosphodiesterase
KM539_02770	COG2353	YceI-like domain
KM539_02795	COG0840	transmembrane signaling receptor activity
KM539_02965	COG0583	DNA-binding transcription factor activity
KM539_02975	COG0697	spore germination
KM539_02985	COG1113	amino acid transport
KM539_02990	COG0598	Magnesium transport protein CorA
KM539_03000	COG2207	Transcriptional regulator
KM539_03020	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KM539_03030	COG0612	Peptidase, M16
KM539_03035	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KM539_03035	COG5297	Belongs to the glycosyl hydrolase family 6
KM539_03060	COG1309	transcriptional regulator
KM539_03095	COG0840	transmembrane signaling receptor activity
KM539_03115	COG3685	Protein conserved in bacteria
KM539_03120	COG3685	Protein conserved in bacteria
KM539_03125	COG1028	Short-chain dehydrogenase reductase Sdr
KM539_03135	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KM539_03150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KM539_03165	COG0028	Belongs to the TPP enzyme family
KM539_03170	COG4191	Histidine kinase
KM539_03175	COG2204	response regulator
KM539_03195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KM539_03195	COG1648	precorrin-2 dehydrogenase activity
KM539_03205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM539_03205	COG1116	anion transmembrane transporter activity
KM539_03210	COG2223	nitrite transmembrane transporter activity
KM539_03215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM539_03220	COG2146	nitrite reductase [NAD(P)H] activity
KM539_03225	COG0243	molybdopterin cofactor binding
KM539_03260	COG1640	4-alpha-glucanotransferase
KM539_03265	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KM539_03285	COG2204	response regulator
KM539_03310	COG0181	hydroxymethylbilane synthase activity
KM539_03325	COG1733	regulation of RNA biosynthetic process
KM539_03345	COG0436	Aminotransferase
KM539_03355	COG2832	Protein of unknown function (DUF454)
KM539_03415	COG2226	methyltransferase
KM539_03440	COG0308	aminopeptidase N
KM539_03445	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM539_03445	COG0596	Alpha beta hydrolase
KM539_03470	COG2010	Cytochrome c
KM539_03480	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KM539_03490	COG3284	Transcriptional regulator
KM539_03495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM539_03500	COG1077	Cell shape determining protein MreB Mrl
KM539_03505	COG1792	Involved in formation and maintenance of cell shape
KM539_03515	COG0768	penicillin binding
KM539_03520	COG0772	Belongs to the SEDS family
KM539_03535	COG2951	lytic endotransglycosylase activity
KM539_03545	COG1686	Belongs to the peptidase S11 family
KM539_03560	COG0321	lipoyl(octanoyl) transferase activity
KM539_03565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KM539_03590	COG1051	belongs to the nudix hydrolase family
KM539_03590	COG1056	cytidyltransferase-related domain
KM539_03615	COG1090	epimerase
KM539_03625	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KM539_03630	COG0673	inositol 2-dehydrogenase activity
KM539_03635	COG2823	Periplasmic or secreted lipoprotein
KM539_03645	COG2202	Pas domain
KM539_03645	COG2205	protein histidine kinase activity
KM539_03650	COG0784	Response regulator, receiver
KM539_03655	COG4191	Histidine kinase
KM539_03665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KM539_03670	COG1028	Short-chain dehydrogenase reductase Sdr
KM539_03685	COG4305	rare lipoprotein A
KM539_03695	COG3250	beta-galactosidase activity
KM539_03710	COG2188	Transcriptional regulator
KM539_03720	COG1609	Transcriptional regulator
KM539_03725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KM539_03730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KM539_03745	COG0617	tRNA 3'-terminal CCA addition
KM539_03765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KM539_03790	COG2207	Transcriptional regulator
KM539_03815	COG2205	protein histidine kinase activity
KM539_03830	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KM539_03845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM539_03855	COG0697	spore germination
KM539_03870	COG1307	EDD domain protein, DegV family
KM539_03885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KM539_03890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KM539_03905	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KM539_03930	COG0436	Aminotransferase
KM539_03970	COG1162	GTPase activity
KM539_04010	COG1028	Short-chain dehydrogenase reductase Sdr
KM539_04015	COG2851	Citrate transporter
KM539_04030	COG0642	Histidine kinase
KM539_04070	COG4191	Histidine kinase
KM539_04080	COG1301	dicarboxylic acid transport
KM539_04085	COG0281	malic enzyme
KM539_04085	COG0280	phosphate acetyltransferase
KM539_04140	COG1560	Kdo2-lipid A biosynthetic process
KM539_04145	COG1519	Transferase
KM539_04150	COG1538	Outer membrane efflux protein
KM539_04155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KM539_04165	COG3706	GGDEF domain
KM539_04170	COG0473	3-isopropylmalate dehydrogenase activity
KM539_04175	COG0066	3-isopropylmalate dehydratase activity
KM539_04195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KM539_04215	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM539_04220	COG0840	transmembrane signaling receptor activity
KM539_04250	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KM539_04260	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KM539_04290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KM539_04315	COG0671	phosphoesterase, PA-phosphatase related
KM539_04330	COG1940	carbohydrate kinase activity
KM539_04340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM539_04355	COG2010	Cytochrome c
KM539_04365	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
KM539_04375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KM539_04390	COG1773	rubredoxin
KM539_04405	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KM539_04415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KM539_04440	COG3079	Belongs to the UPF0149 family
KM539_04445	COG0006	proline dipeptidase activity
KM539_04450	COG0006	proline dipeptidase activity
KM539_04470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM539_04475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KM539_04480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KM539_04485	COG1561	YicC-like family, N-terminal region
KM539_04490	COG0194	GDP metabolic process
KM539_04495	COG1758	RNA polymerase activity
KM539_04500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KM539_04520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KM539_04530	COG0254	rRNA binding
KM539_04545	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KM539_04575	COG0714	Associated with various cellular activities
KM539_04605	COG1301	dicarboxylic acid transport
KM539_04610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KM539_04660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM539_04665	COG1404	Belongs to the peptidase S8 family
KM539_04670	COG1404	Belongs to the peptidase S8 family
KM539_04675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KM539_04695	COG1295	ribonuclease BN
KM539_04700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM539_04720	COG0521	Mo-molybdopterin cofactor biosynthetic process
KM539_04725	COG5297	Belongs to the glycosyl hydrolase family 6
KM539_04740	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KM539_04745	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KM539_04760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KM539_04770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KM539_04780	COG0193	aminoacyl-tRNA hydrolase activity
KM539_04785	COG0012	GTP binding
KM539_04805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KM539_04815	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM539_04820	COG0250	Participates in transcription elongation, termination and antitermination
KM539_04825	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KM539_04840	COG0222	ribosome binding
KM539_04850	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KM539_04865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KM539_04870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KM539_04875	COG0051	transcription antitermination factor activity, RNA binding
KM539_04885	COG0088	Forms part of the polypeptide exit tunnel
KM539_04890	COG0089	rRNA binding
KM539_04895	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KM539_04920	COG0255	Belongs to the universal ribosomal protein uL29 family
KM539_04925	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KM539_04935	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KM539_04940	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KM539_04970	COG1841	ribosomal large subunit assembly
KM539_04980	COG0201	protein transport
KM539_05005	COG0203	ribosomal protein L17
KM539_05010	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KM539_05020	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KM539_05040	COG1217	gtp-binding protein TYPA
KM539_05045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KM539_05055	COG0039	L-malate dehydrogenase activity
KM539_05065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM539_05070	COG0625	glutathione transferase activity
KM539_05115	COG0446	pyridine nucleotide-disulphide oxidoreductase
KM539_05115	COG1902	pentaerythritol trinitrate reductase activity
KM539_05120	COG0604	alcohol dehydrogenase
KM539_05125	COG0667	Aldo Keto reductase
KM539_05135	COG2814	Major facilitator Superfamily
KM539_05140	COG0583	DNA-binding transcription factor activity
KM539_05145	COG2885	chlorophyll binding
KM539_05155	COG1187	pseudouridine synthase activity
KM539_05160	COG0156	8-amino-7-oxononanoate synthase activity
KM539_05165	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KM539_05170	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KM539_05175	COG4208	sulfate ABC transporter
KM539_05180	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KM539_05200	COG0588	phosphoglycerate mutase activity
KM539_05205	COG0285	dihydrofolate synthase activity
KM539_05225	COG2833	Protein of unknown function (DUF455)
KM539_05235	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KM539_05250	COG0438	transferase activity, transferring glycosyl groups
KM539_05260	COG0248	Ppx GppA phosphatase
KM539_05265	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KM539_05280	COG4783	chaperone-mediated protein folding
KM539_05295	COG0473	3-isopropylmalate dehydrogenase activity
KM539_05335	COG0544	peptidyl-prolyl cis-trans isomerase activity
KM539_05345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KM539_05375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM539_05380	COG1388	LysM domain
KM539_05380	COG3942	CHAP domain
KM539_05385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM539_05395	COG0328	RNA-DNA hybrid ribonuclease activity
KM539_05405	COG0631	protein serine/threonine phosphatase activity
KM539_05425	COG0859	PFAM glycosyl transferase family 9
KM539_05435	COG1234	tRNA 3'-trailer cleavage
KM539_05440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KM539_05450	COG0315	cyclic pyranopterin monophosphate synthase activity
KM539_05455	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KM539_05460	COG0314	molybdopterin synthase activity
KM539_05495	COG3041	Addiction module toxin RelE StbE family
KM539_05550	COG0537	adenosine 5'-monophosphoramidase activity
KM539_05570	COG0714	Associated with various cellular activities
KM539_05595	COG1399	metal-binding, possibly nucleic acid-binding protein
KM539_05600	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KM539_05605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM539_05610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KM539_05615	COG1028	Short-chain dehydrogenase reductase Sdr
KM539_05620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM539_05630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KM539_05635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KM539_05640	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KM539_05690	COG0587	DNA-directed DNA polymerase activity
KM539_05705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KM539_05710	COG0372	Belongs to the citrate synthase family
KM539_05755	COG2373	Large extracellular alpha-helical protein
KM539_05775	COG4953	penicillin-binding protein 1C
KM539_05785	COG0678	peroxiredoxin activity
KM539_05805	COG0604	alcohol dehydrogenase
KM539_05810	COG0330	HflC and HflK could
KM539_05815	COG0330	HflC and HflK could
KM539_05830	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KM539_05900	COG3275	phosphorelay sensor kinase activity
KM539_05960	COG3459	Glycosyltransferase 36 associated
KM539_05970	COG1063	alcohol dehydrogenase
KM539_05995	COG0753	catalase activity
KM539_06000	COG5001	Diguanylate cyclase
KM539_06000	COG2203	Gaf domain
KM539_06000	COG3706	GGDEF domain
KM539_06000	COG4251	negative regulation of phosphorylation
KM539_06010	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KM539_06010	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KM539_06035	COG2814	Major facilitator Superfamily
KM539_06085	COG2194	sulfuric ester hydrolase activity
KM539_06095	COG0745	RESPONSE REGULATOR receiver
KM539_06100	COG2205	protein histidine kinase activity
KM539_06110	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KM539_06115	COG2894	cell division
KM539_06120	COG0850	regulation of cytokinetic process
KM539_06130	COG4585	Histidine kinase
KM539_06150	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM539_06165	COG1216	Glycosyl transferase, family 2
KM539_06170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM539_06180	COG1199	ATP-dependent helicase activity
KM539_06200	COG0189	ligase activity
KM539_06215	COG0835	chemotaxis
KM539_06220	COG0840	transmembrane signaling receptor activity
KM539_06225	COG2198	Histidine kinase
KM539_06225	COG0784	Response regulator, receiver
KM539_06225	COG0643	Histidine kinase
KM539_06230	COG2201	protein-glutamate methylesterase activity
KM539_06270	COG1446	asparaginase
KM539_06275	COG3142	Participates in the control of copper homeostasis
KM539_06330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KM539_06355	COG0628	permease
KM539_06365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KM539_06370	COG3178	'Phosphotransferase
KM539_06385	COG1555	photosystem II stabilization
KM539_06405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KM539_06410	COG1477	protein flavinylation
KM539_06435	COG4774	siderophore transport
KM539_06440	COG2146	nitrite reductase [NAD(P)H] activity
KM539_06450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KM539_06455	COG0719	Fe-S assembly protein
KM539_06460	COG0396	ATPase activity
KM539_06465	COG0719	Fe-S assembly protein
KM539_06480	COG0693	protein deglycase activity
KM539_06500	COG0739	heme binding
KM539_06515	COG1764	response to oxidative stress
KM539_06525	COG0384	phenazine biosynthesis protein PhzF
KM539_06530	COG0527	aspartate kinase activity
KM539_06555	COG0142	geranyltranstransferase activity
KM539_06560	COG0629	single-stranded DNA binding
KM539_06565	COG3550	peptidyl-serine autophosphorylation
KM539_06605	COG2192	nodulation
KM539_06620	COG1297	OPT oligopeptide transporter protein
KM539_06625	COG0823	Involved in the tonB-independent uptake of proteins
KM539_06625	COG1506	peptidase
KM539_06645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KM539_06655	COG2879	small protein
KM539_06660	COG1966	Carbon starvation protein
KM539_06665	COG1741	Belongs to the pirin family
KM539_06680	COG1515	deoxyribonuclease V activity
KM539_06700	COG2211	Major facilitator Superfamily
KM539_06725	COG2203	Gaf domain
KM539_06725	COG3706	GGDEF domain
KM539_06725	COG4251	negative regulation of phosphorylation
KM539_06725	COG5001	Diguanylate cyclase
KM539_06730	COG0835	chemotaxis
KM539_06735	COG0840	transmembrane signaling receptor activity
KM539_06740	COG0840	transmembrane signaling receptor activity
KM539_06745	COG0840	transmembrane signaling receptor activity
KM539_06750	COG0643	Histidine kinase
KM539_06750	COG2198	Histidine kinase
KM539_06760	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KM539_06775	COG3878	Protein conserved in bacteria
KM539_06780	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KM539_06785	COG0745	RESPONSE REGULATOR receiver
KM539_06810	COG4452	Inner membrane protein CreD
KM539_06845	COG0735	belongs to the Fur family
KM539_06855	COG0667	Aldo Keto reductase
KM539_07005	COG1187	pseudouridine synthase activity
KM539_07030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KM539_07055	COG1132	(ABC) transporter
KM539_07120	COG1981	membrane
KM539_07130	COG0825	malonyl-CoA metabolic process
KM539_07145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KM539_07150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KM539_07160	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KM539_07165	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KM539_07170	COG0750	zinc metalloprotease
KM539_07175	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KM539_07180	COG0575	Belongs to the CDS family
KM539_07185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KM539_07195	COG0528	UMP kinase activity
KM539_07205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KM539_07245	COG0024	Methionine aminopeptidase
KM539_07260	COG1393	Belongs to the ArsC family
KM539_07265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM539_07275	COG0367	asparagine synthase
KM539_07315	COG1566	PFAM secretion protein HlyD family protein
KM539_07320	COG2814	Major facilitator Superfamily
KM539_07360	COG0557	exoribonuclease II activity
KM539_07370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM539_07385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KM539_07405	COG0704	Plays a role in the regulation of phosphate uptake
KM539_07415	COG0581	inorganic phosphate transmembrane transporter activity
KM539_07425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM539_07430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM539_07450	COG0659	secondary active sulfate transmembrane transporter activity
KM539_07465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KM539_07475	COG1024	Enoyl-CoA hydratase
KM539_07515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KM539_07525	COG0494	nUDIX hydrolase
KM539_07530	COG1218	3'(2'),5'-bisphosphate nucleotidase
KM539_07535	COG3956	TIGRFAM MazG family protein
KM539_07540	COG1742	UPF0060 membrane protein
KM539_07545	COG0330	HflC and HflK could
KM539_07595	COG0697	spore germination
KM539_07625	COG2124	cytochrome p450
KM539_07630	COG2124	cytochrome p450
KM539_07635	COG1141	Ferredoxin
KM539_07640	COG1028	Short-chain dehydrogenase reductase Sdr
KM539_07645	COG2124	cytochrome p450
KM539_07650	COG0142	geranyltranstransferase activity
KM539_07655	COG1657	PFAM Prenyltransferase squalene oxidase
KM539_07665	COG1304	FMN binding
KM539_07670	COG0475	glutathione-regulated potassium exporter activity
KM539_07695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KM539_07700	COG2070	2-Nitropropane dioxygenase
KM539_07710	COG0228	four-way junction DNA binding
KM539_07715	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KM539_07725	COG0335	large ribosomal subunit rRNA binding
KM539_07730	COG0534	Mate efflux family protein
KM539_07760	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KM539_07780	COG4245	von Willebrand factor, type A
KM539_07785	COG0631	protein serine/threonine phosphatase activity
KM539_07790	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
KM539_07920	COG2855	membrane
KM539_07940	COG1024	Enoyl-CoA hydratase
KM539_07940	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM539_07955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM539_07960	COG0481	GTPase activity
KM539_07965	COG0681	Belongs to the peptidase S26 family
KM539_07980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KM539_07985	COG1381	Involved in DNA repair and RecF pathway recombination
KM539_08000	COG2954	triphosphatase activity
KM539_08010	COG1472	Belongs to the glycosyl hydrolase 3 family
KM539_08015	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KM539_08020	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KM539_08025	COG1278	Cold shock
KM539_08040	COG1201	RNA secondary structure unwinding
KM539_08045	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KM539_08045	COG1793	dna ligase
KM539_08050	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KM539_08050	COG1793	dna ligase
KM539_08080	COG0443	Heat shock 70 kDa protein
KM539_08090	COG0183	Belongs to the thiolase family
KM539_08120	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KM539_08120	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KM539_08120	COG1703	isobutyryl-CoA mutase activity
KM539_08165	COG3250	beta-galactosidase activity
KM539_08170	COG2186	Transcriptional regulator
KM539_08180	COG2205	protein histidine kinase activity
KM539_08180	COG0784	Response regulator, receiver
KM539_08180	COG2198	Histidine kinase
KM539_08200	COG1451	nucleotide metabolic process
KM539_08210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KM539_08245	COG1077	Cell shape determining protein MreB Mrl
KM539_08250	COG1047	Peptidyl-prolyl cis-trans
KM539_08260	COG2824	Alkylphosphonate utilization operon protein PhnA
KM539_08265	COG1902	pentaerythritol trinitrate reductase activity
KM539_08270	COG2814	Major facilitator Superfamily
KM539_08300	COG0392	lysyltransferase activity
KM539_08300	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KM539_08310	COG0251	oxidation-reduction process
KM539_08335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KM539_08360	COG1595	DNA-templated transcription, initiation
KM539_08375	COG2878	Part of a membrane complex involved in electron transport
KM539_08415	COG0346	lactoylglutathione lyase activity
KM539_08425	COG2040	homocysteine
KM539_08435	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KM539_08450	COG3118	belongs to the thioredoxin family
KM539_08460	COG0495	leucyl-tRNA aminoacylation
KM539_08475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KM539_08490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KM539_08505	COG2968	Membrane
KM539_08530	COG0312	modulator of DNA gyrase
KM539_08540	COG0312	modulator of DNA gyrase
KM539_08555	COG4104	PAAR repeat-containing protein
KM539_08560	COG0142	geranyltranstransferase activity
KM539_08565	COG1722	exodeoxyribonuclease VII activity
KM539_08580	COG1785	Belongs to the alkaline phosphatase family
KM539_08585	COG1301	dicarboxylic acid transport
KM539_08595	COG1607	acyl-coa hydrolase
KM539_08600	COG0791	NLP P60 protein
KM539_08605	COG0791	NLP P60 protein
KM539_08610	COG1047	Peptidyl-prolyl cis-trans
KM539_08615	COG2311	Membrane
KM539_08620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM539_08685	COG3590	peptidase
KM539_08700	COG0457	Tetratricopeptide repeat
KM539_08705	COG4771	TonB-dependent receptor
KM539_08710	COG4771	TonB-dependent receptor
KM539_08720	COG0489	protein tyrosine kinase activity
KM539_08725	COG0717	Belongs to the dCTP deaminase family
KM539_08730	COG1714	RDD family
KM539_08750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KM539_08765	COG0494	nUDIX hydrolase
KM539_08770	COG0433	COG0433 Predicted ATPase
KM539_08775	COG0741	lytic transglycosylase activity
KM539_08785	COG0688	phosphatidylethanolamine metabolic process
KM539_08795	COG2890	protein-(glutamine-N5) methyltransferase activity
KM539_08830	COG3853	Toxic anion resistance protein (TelA)
KM539_08855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KM539_08885	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM539_08895	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM539_08900	COG0649	NAD binding
KM539_08905	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KM539_08910	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KM539_08915	COG1034	ATP synthesis coupled electron transport
KM539_08950	COG1007	ATP synthesis coupled electron transport
KM539_08965	COG0195	Participates in both transcription termination and antitermination
KM539_08980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KM539_08990	COG1185	polyribonucleotide nucleotidyltransferase activity
KM539_08995	COG3300	MHYT domain
KM539_08995	COG5001	Diguanylate cyclase
KM539_09010	COG1201	RNA secondary structure unwinding
KM539_09020	COG0840	transmembrane signaling receptor activity
KM539_09025	COG0840	transmembrane signaling receptor activity
KM539_09030	COG0835	chemotaxis
KM539_09080	COG0582	viral genome integration into host DNA
KM539_09120	COG1194	a g-specific adenine glycosylase
KM539_09125	COG0552	protein localization to endoplasmic reticulum
KM539_09135	COG3938	Belongs to the proline racemase family
KM539_09140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM539_09155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KM539_09165	COG0006	proline dipeptidase activity
KM539_09180	COG0531	amino acid
KM539_09220	COG3507	Belongs to the glycosyl hydrolase 43 family
KM539_09230	COG4771	TonB-dependent receptor
KM539_09260	COG0742	ribosomal rna small subunit methyltransferase
KM539_09275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KM539_09280	COG0405	Gamma-glutamyltransferase
KM539_09300	COG0644	oxidoreductase
KM539_09330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM539_09335	COG3291	Pkd domain containing protein
KM539_09340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KM539_09350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM539_09360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KM539_09370	COG1862	Preprotein translocase
KM539_09400	COG2203	Gaf domain
KM539_09400	COG5001	Diguanylate cyclase
KM539_09400	COG4251	negative regulation of phosphorylation
KM539_09400	COG3706	GGDEF domain
KM539_09405	COG1509	lysine 2,3-aminomutase activity
KM539_09415	COG3548	integral membrane protein
KM539_09420	COG0402	S-adenosylhomocysteine deaminase activity
KM539_09440	COG4677	pectinesterase activity
KM539_09450	COG5434	Belongs to the glycosyl hydrolase 28 family
KM539_09455	COG4677	pectinesterase activity
KM539_09465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KM539_09500	COG2814	Major facilitator Superfamily
KM539_09505	COG2166	iron-sulfur cluster assembly
KM539_09520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KM539_09525	COG0137	argininosuccinate synthase activity
KM539_09530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM539_09535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KM539_09550	COG0165	Argininosuccinate lyase
KM539_09570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KM539_09595	COG1294	oxidase, subunit
KM539_09605	COG4988	ABC transporter
KM539_09610	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KM539_09615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM539_09660	COG4133	protoheme IX ABC transporter activity
KM539_09665	COG0436	Aminotransferase
KM539_09700	COG1187	pseudouridine synthase activity
KM539_09705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KM539_09710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KM539_09715	COG2350	Protein conserved in bacteria
KM539_09750	COG0395	ABC-type sugar transport system, permease component
KM539_09760	COG0800	Aldolase
KM539_09765	COG0129	dihydroxy-acid dehydratase activity
KM539_09780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM539_09785	COG3842	ATPase activity
KM539_09790	COG0354	folic acid binding
KM539_09800	COG2009	succinate dehydrogenase
KM539_09805	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KM539_09830	COG4591	ABC-type transport system involved in lipoprotein release permease component
KM539_09850	COG0811	peptide transport
KM539_09855	COG0848	biopolymer transport protein
KM539_09860	COG1132	(ABC) transporter
KM539_09865	COG1663	tetraacyldisaccharide 4'-kinase activity
KM539_09875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KM539_09890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KM539_09920	COG0348	domain, Protein
KM539_09930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM539_09940	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
KM539_09945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM539_09955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM539_10015	COG1136	(ABC) transporter
KM539_10015	COG0577	efflux transmembrane transporter activity
KM539_10045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM539_10045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM539_10050	COG1105	Belongs to the carbohydrate kinase PfkB family
KM539_10055	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM539_10055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KM539_10060	COG1609	Transcriptional regulator
KM539_10075	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KM539_10080	COG0069	glutamate synthase activity
KM539_10120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM539_10135	COG1253	flavin adenine dinucleotide binding
KM539_10165	COG0504	CTP synthase activity
KM539_10170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KM539_10180	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KM539_10185	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KM539_10190	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KM539_10205	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KM539_10215	COG1238	metal cluster binding
KM539_10230	COG1534	Rna-binding protein
KM539_10235	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KM539_10240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM539_10245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KM539_10260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KM539_10275	COG1546	Belongs to the CinA family
KM539_10285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KM539_10290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KM539_10295	COG2137	regulation of response to DNA damage stimulus
KM539_10300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM539_10370	COG1741	Belongs to the pirin family
KM539_10375	COG0583	DNA-binding transcription factor activity
KM539_10395	COG0351	phosphomethylpyrimidine kinase
KM539_10395	COG0352	thiamine-phosphate diphosphorylase activity
KM539_10410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KM539_10415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KM539_10425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KM539_10435	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KM539_10440	COG3734	2-keto-3-deoxy-galactonokinase
KM539_10455	COG0800	Aldolase
KM539_10475	COG1501	Belongs to the glycosyl hydrolase 31 family
KM539_10485	COG1070	Carbohydrate kinase
KM539_10490	COG2115	Belongs to the xylose isomerase family
KM539_10495	COG0477	Major facilitator Superfamily
KM539_10500	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM539_10520	COG0617	tRNA 3'-terminal CCA addition
KM539_10530	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KM539_10545	COG0166	Belongs to the GPI family
KM539_10565	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
KM539_10580	COG0671	phosphoesterase, PA-phosphatase related
KM539_10610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM539_10615	COG0167	dihydroorotate dehydrogenase activity
KM539_10630	COG1012	belongs to the aldehyde dehydrogenase family
KM539_10645	COG0460	homoserine dehydrogenase
KM539_10645	COG0527	aspartate kinase activity
KM539_10650	COG0083	homoserine kinase activity
KM539_10655	COG2951	lytic endotransglycosylase activity
KM539_10665	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KM539_10675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM539_10680	COG0124	histidyl-tRNA synthetase
KM539_10690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KM539_10695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KM539_10700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM539_10710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KM539_10725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KM539_10725	COG0140	phosphoribosyl-ATP diphosphatase activity
KM539_10750	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
KM539_10755	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KM539_10760	COG0235	Class ii aldolase
KM539_10765	COG0531	amino acid
KM539_10770	COG0531	amino acid
KM539_10785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KM539_10790	COG0277	FAD linked oxidase domain protein
KM539_10810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KM539_10830	COG1024	Enoyl-CoA hydratase
KM539_10860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM539_10865	COG2258	MOSC domain
KM539_10875	COG0505	Belongs to the CarA family
KM539_10885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KM539_10890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KM539_10900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KM539_10905	COG4676	Protein conserved in bacteria
KM539_10910	COG3279	Response regulator of the LytR AlgR family
KM539_10930	COG2205	protein histidine kinase activity
KM539_10930	COG2198	Histidine kinase
KM539_10930	COG0784	Response regulator, receiver
KM539_10935	COG1024	Enoyl-CoA hydratase
KM539_10940	COG0318	PFAM AMP-dependent synthetase and ligase
KM539_11030	COG0840	transmembrane signaling receptor activity
KM539_11040	COG0840	transmembrane signaling receptor activity
KM539_11050	COG0835	chemotaxis
KM539_11060	COG0840	transmembrane signaling receptor activity
KM539_11070	COG0840	transmembrane signaling receptor activity
KM539_11075	COG0840	transmembrane signaling receptor activity
KM539_11080	COG0840	transmembrane signaling receptor activity
KM539_11090	COG0840	transmembrane signaling receptor activity
KM539_11095	COG0840	transmembrane signaling receptor activity
KM539_11100	COG0840	transmembrane signaling receptor activity
KM539_11105	COG0840	transmembrane signaling receptor activity
KM539_11115	COG0745	RESPONSE REGULATOR receiver
KM539_11130	COG1192	Involved in chromosome partitioning
KM539_11140	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM539_11150	COG0784	Response regulator, receiver
KM539_11150	COG0643	Histidine kinase
KM539_11150	COG2198	Histidine kinase
KM539_11155	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
KM539_11200	COG1684	flagellar biosynthetic protein fliR
KM539_11205	COG1987	bacterial-type flagellum assembly
KM539_11215	COG3190	flagellar
KM539_11265	COG1677	Flagellar hook-basal body complex protein FliE
KM539_11300	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KM539_11325	COG1028	Short-chain dehydrogenase reductase Sdr
KM539_11335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM539_11355	COG2201	protein-glutamate methylesterase activity
KM539_11360	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KM539_11365	COG2197	response regulator
KM539_11385	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KM539_11390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KM539_11395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KM539_11400	COG1256	bacterial-type flagellum assembly
KM539_11400	COG4786	Flagellar basal body rod
KM539_11415	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KM539_11430	COG1749	Flagellar hook protein flgE
KM539_11440	COG1558	bacterial-type flagellum-dependent cell motility
KM539_11450	COG0784	Response regulator, receiver
KM539_11450	COG0835	chemotaxis
KM539_11495	COG1116	anion transmembrane transporter activity
KM539_11515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM539_11535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KM539_11540	COG2957	Belongs to the agmatine deiminase family
KM539_11555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KM539_11560	COG0539	negative regulation of cytoplasmic translation
KM539_11565	COG0776	regulation of translation
KM539_11575	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KM539_11580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KM539_11590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM539_11595	COG0183	Belongs to the thiolase family
KM539_11600	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM539_11600	COG1024	Enoyl-CoA hydratase
KM539_11615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KM539_11625	COG1426	Protein conserved in bacteria
KM539_11635	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KM539_11645	COG0746	molybdenum cofactor guanylyltransferase activity
KM539_11655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM539_11660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM539_11660	COG0475	glutathione-regulated potassium exporter activity
KM539_11680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KM539_11715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM539_11720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM539_11725	COG1538	Outer membrane efflux protein
KM539_11735	COG2207	Transcriptional regulator
KM539_11740	COG1501	Belongs to the glycosyl hydrolase 31 family
KM539_11745	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KM539_11755	COG1914	H( )-stimulated, divalent metal cation uptake system
KM539_11770	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KM539_11775	COG0668	transmembrane transport
KM539_11800	COG1028	Short-chain dehydrogenase reductase Sdr
KM539_11805	COG1183	phosphatidylcholine synthase activity
KM539_11815	COG3243	poly(R)-hydroxyalkanoic acid synthase
KM539_11835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM539_11835	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KM539_11845	COG0784	Response regulator, receiver
KM539_11845	COG4191	Histidine kinase
KM539_11850	COG2183	response to ionizing radiation
KM539_11855	COG0784	Response regulator, receiver
KM539_11855	COG2205	protein histidine kinase activity
KM539_11920	COG1649	PFAM Uncharacterised BCR, COG1649
KM539_11945	COG1132	(ABC) transporter
KM539_11970	COG0438	transferase activity, transferring glycosyl groups
KM539_11975	COG0297	glycogen (starch) synthase activity
KM539_12015	COG2244	polysaccharide biosynthetic process
KM539_12045	COG3038	cytochrome b561
KM539_12065	COG1595	DNA-templated transcription, initiation
KM539_12100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM539_12140	COG0038	chloride channel
KM539_12145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KM539_12175	COG1674	ftsk spoiiie
KM539_12180	COG0492	ferredoxin-NADP+ reductase activity
KM539_12200	COG0542	response to heat
KM539_12220	COG0482	sulfurtransferase activity
KM539_12225	COG2915	High frequency lysogenization protein hflD homolog
KM539_12255	COG0316	Belongs to the HesB IscA family
KM539_12255	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KM539_12270	COG0428	transporter
KM539_12285	COG1530	ribonuclease E activity
KM539_12345	COG0077	Prephenate dehydratase
KM539_12345	COG1605	Chorismate mutase
KM539_12350	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KM539_12355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KM539_12395	COG4221	oxidoreductase activity
KM539_12410	COG1228	amidohydrolase
KM539_12430	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KM539_12445	COG1309	transcriptional regulator
KM539_12475	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KM539_12485	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KM539_12490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KM539_12495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM539_12525	COG2977	Belongs to the P-Pant transferase superfamily
KM539_12530	COG0316	Belongs to the HesB IscA family
KM539_12555	COG2197	response regulator
KM539_12600	COG0288	reversible hydration of carbon dioxide
KM539_12615	COG3844	kynureninase activity
KM539_12625	COG2925	Exonuclease
KM539_12655	COG2902	Dehydrogenase
KM539_12665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM539_12670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM539_12675	COG1960	acyl-CoA dehydrogenase activity
KM539_12680	COG2226	methyltransferase
KM539_12685	COG1410	methionine synthase
KM539_12685	COG0646	methionine synthase
KM539_12690	COG1410	methionine synthase
KM539_12690	COG0646	methionine synthase
KM539_12700	COG2755	lipolytic protein G-D-S-L family
KM539_12700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KM539_12710	COG2900	Belongs to the SlyX family
KM539_12725	COG0386	Belongs to the glutathione peroxidase family
KM539_12735	COG1725	Transcriptional regulator
KM539_12740	COG1131	(ABC) transporter
KM539_12790	COG2885	chlorophyll binding
KM539_12800	COG2850	peptidyl-arginine hydroxylation
KM539_12810	COG0567	Dehydrogenase, E1 component
KM539_12830	COG5001	Diguanylate cyclase
KM539_12850	COG1132	(ABC) transporter
KM539_12860	COG0287	Prephenate dehydrogenase
KM539_12860	COG1605	Chorismate mutase
KM539_12865	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
KM539_12870	COG0484	heat shock protein binding
KM539_12875	COG0443	Heat shock 70 kDa protein
KM539_12880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KM539_12885	COG1420	regulation of RNA biosynthetic process
KM539_12890	COG0497	DNA recombination
KM539_12895	COG0735	belongs to the Fur family
KM539_12900	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KM539_12910	COG2867	negative regulation of translational initiation
KM539_12915	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KM539_12925	COG1404	Belongs to the peptidase S8 family
KM539_12945	COG3209	COG3209 Rhs family protein
KM539_12990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM539_13005	COG0583	DNA-binding transcription factor activity
KM539_13020	COG0415	Belongs to the DNA photolyase family
KM539_13025	COG0305	Participates in initiation and elongation during chromosome replication
KM539_13035	COG1960	acyl-CoA dehydrogenase activity
KM539_13050	COG0084	hydrolase, TatD family'
KM539_13055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KM539_13130	COG0386	Belongs to the glutathione peroxidase family
KM539_13140	COG0339	signal peptide processing
KM539_13145	COG1846	Transcriptional regulator
KM539_13180	COG1472	Belongs to the glycosyl hydrolase 3 family
KM539_13190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM539_13205	COG0488	(ABC) transporter
KM539_13210	COG0513	Belongs to the DEAD box helicase family
KM539_13240	COG0657	acetylesterase activity
KM539_13245	COG0625	glutathione transferase activity
KM539_13255	COG0564	pseudouridine synthase activity
KM539_13260	COG4681	YaeQ
KM539_13265	COG2081	HI0933 family
KM539_13295	COG1028	Short-chain dehydrogenase reductase Sdr
KM539_13315	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KM539_13320	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM539_13325	COG0802	atpase or kinase
KM539_13330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KM539_13330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KM539_13335	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KM539_13375	COG1960	acyl-CoA dehydrogenase activity
KM539_13385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KM539_13405	COG0438	transferase activity, transferring glycosyl groups
KM539_13415	COG0438	transferase activity, transferring glycosyl groups
KM539_13420	COG0438	transferase activity, transferring glycosyl groups
KM539_13470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KM539_13475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KM539_13485	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KM539_13565	COG2948	multi-organism process
KM539_13600	COG0556	nucleotide-excision repair
KM539_13650	COG1611	Belongs to the LOG family
KM539_13660	COG2095	MarC family integral membrane protein
KM539_13665	COG0300	oxidoreductase activity
KM539_13670	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KM539_13710	COG2969	positive regulation of protein catabolic process
KM539_13715	COG0625	glutathione transferase activity
KM539_13720	COG2857	Cytochrome c1
KM539_13730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KM539_13735	COG0723	plastoquinol--plastocyanin reductase activity
KM539_13740	COG0741	lytic transglycosylase activity
KM539_13745	COG0625	glutathione transferase activity
KM539_13755	COG1702	phosphate starvation-inducible protein PhoH
KM539_13770	COG4535	Mg2 and Co2 transporter CorC
KM539_13785	COG1012	belongs to the aldehyde dehydrogenase family
KM539_13795	COG1177	transmembrane transport
KM539_13800	COG1176	ABC-type spermidine putrescine transport system, permease component I
KM539_13805	COG3842	ATPase activity
KM539_13825	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KM539_13840	COG0174	glutamine synthetase
KM539_13845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KM539_13850	COG0174	glutamine synthetase
KM539_13855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM539_13860	COG3706	GGDEF domain
KM539_13865	COG0477	Major facilitator Superfamily
KM539_13885	COG0243	molybdopterin cofactor binding
KM539_13895	COG2223	nitrite transmembrane transporter activity
KM539_13915	COG1012	belongs to the aldehyde dehydrogenase family
KM539_13920	COG1396	sequence-specific DNA binding
KM539_13920	COG1917	Cupin 2, conserved barrel domain protein
KM539_13925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM539_13930	COG0686	Belongs to the AlaDH PNT family
KM539_13950	COG2733	membrane
KM539_13955	COG0784	Response regulator, receiver
KM539_13955	COG2205	protein histidine kinase activity
KM539_13955	COG5002	protein histidine kinase activity
KM539_13995	COG0837	glucose binding
KM539_14010	COG3858	chitin binding
KM539_14010	COG1388	LysM domain
KM539_14015	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KM539_14025	COG1472	Belongs to the glycosyl hydrolase 3 family
KM539_14040	COG3537	Alpha-1,2-mannosidase
KM539_14140	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KM539_14155	COG1137	ATPase activity
KM539_14170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM539_14180	COG1660	Displays ATPase and GTPase activities
KM539_14190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM539_14195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KM539_14200	COG2239	Acts as a magnesium transporter
KM539_14220	COG1113	amino acid transport
KM539_14230	COG0840	transmembrane signaling receptor activity
KM539_14255	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KM539_14270	COG0519	Catalyzes the synthesis of GMP from XMP
KM539_14285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KM539_14350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM539_14360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KM539_14365	COG2814	Major facilitator Superfamily
KM539_14385	COG3038	cytochrome b561
KM539_14400	COG1760	l-serine dehydratase
KM539_14410	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM539_14410	COG0596	Alpha beta hydrolase
KM539_14415	COG0460	homoserine dehydrogenase
KM539_14415	COG0527	aspartate kinase activity
KM539_14420	COG0626	cystathionine gamma-synthase activity
KM539_14425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM539_14435	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KM539_14440	COG1272	protein, Hemolysin III
KM539_14445	COG2982	Protein involved in outer membrane biogenesis
KM539_14450	COG0517	IMP dehydrogenase activity
KM539_14455	COG0463	Glycosyl transferase, family 2
KM539_14460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM539_14465	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KM539_14485	COG1309	transcriptional regulator
KM539_14495	COG1960	acyl-CoA dehydrogenase activity
KM539_14505	COG0625	glutathione transferase activity
KM539_14510	COG1082	Xylose isomerase domain protein TIM barrel
KM539_14520	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM539_14525	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM539_14530	COG1129	ABC transporter
KM539_14535	COG1879	ABC-type sugar transport system periplasmic component
KM539_14540	COG1012	belongs to the aldehyde dehydrogenase family
KM539_14565	COG0129	dihydroxy-acid dehydratase activity
KM539_14590	COG2207	Transcriptional regulator
KM539_14615	COG1317	bacterial-type flagellum organization
KM539_14640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM539_14665	COG4794	Type iii secretion
KM539_14695	COG0745	RESPONSE REGULATOR receiver
KM539_14750	COG3152	Membrane
KM539_14760	COG0156	8-amino-7-oxononanoate synthase activity
KM539_14770	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KM539_14775	COG1845	cytochrome c oxidase, subunit III
KM539_14780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KM539_14820	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KM539_14835	COG0196	riboflavin kinase activity
KM539_14875	COG0728	peptidoglycan biosynthetic process
KM539_14890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KM539_14895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KM539_14900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM539_14905	COG0824	Thioesterase
KM539_14915	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM539_14915	COG1024	Enoyl-CoA hydratase
KM539_14920	COG1946	Acyl-CoA thioesterase
KM539_14935	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KM539_14975	COG1073	alpha beta
KM539_15000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KM539_15050	COG1643	Atp-dependent helicase
KM539_15055	COG0783	Belongs to the Dps family
KM539_15065	COG0514	ATP-dependent DNA helicase (RecQ)
KM539_15090	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KM539_15095	COG0602	queuosine metabolic process
KM539_15105	COG2885	chlorophyll binding
KM539_15120	COG0848	biopolymer transport protein
KM539_15130	COG0824	Thioesterase
KM539_15135	COG2255	four-way junction helicase activity
KM539_15140	COG3158	transport of potassium into the cell
KM539_15145	COG0632	four-way junction helicase activity
KM539_15155	COG0217	transcriptional regulatory protein
KM539_15205	COG2755	lipolytic protein G-D-S-L family
KM539_15205	COG0657	acetylesterase activity
KM539_15230	COG0488	(ABC) transporter
KM539_15290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM539_15290	COG4651	solute:proton antiporter activity
KM539_15300	COG4772	TonB-dependent receptor
KM539_15310	COG4264	IucA IucC family
KM539_15315	COG2814	Major facilitator Superfamily
KM539_15320	COG4264	IucA IucC family
KM539_15325	COG0019	diaminopimelate decarboxylase activity
KM539_15350	COG0542	response to heat
KM539_15385	COG0454	-acetyltransferase
KM539_15405	COG1877	trehalose-phosphatase activity
KM539_15410	COG3387	PFAM Glycoside hydrolase 15-related
KM539_15425	COG4993	Dehydrogenase
KM539_15430	COG0840	transmembrane signaling receptor activity
KM539_15440	COG0564	pseudouridine synthase activity
KM539_15445	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KM539_15455	COG1125	glycine betaine transport
KM539_15460	COG1174	glycine betaine transport
KM539_15475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KM539_15485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KM539_15485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KM539_15515	COG3657	addiction module killer protein
KM539_15520	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KM539_15545	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KM539_15560	COG0745	RESPONSE REGULATOR receiver
KM539_15570	COG0189	ligase activity
KM539_15580	COG3511	phospholipase C
KM539_15600	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KM539_15615	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KM539_15630	COG0174	glutamine synthetase
KM539_15650	COG2022	thiamine diphosphate biosynthetic process
KM539_15660	COG3273	potassium ion transport
KM539_15660	COG0471	metal ion transport
KM539_15675	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM539_15690	COG1609	Transcriptional regulator
KM539_15705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM539_15715	COG1115	amino acid carrier protein
KM539_15735	COG0438	transferase activity, transferring glycosyl groups
KM539_15740	COG0840	transmembrane signaling receptor activity
KM539_15745	COG2895	sulfate adenylyltransferase (ATP) activity
KM539_15745	COG0529	Catalyzes the synthesis of activated sulfate
KM539_15750	COG0175	sulfate reduction
KM539_15755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KM539_15760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM539_15765	COG0175	sulfate reduction
KM539_15800	COG2205	protein histidine kinase activity
KM539_15800	COG0784	Response regulator, receiver
KM539_15800	COG2198	Histidine kinase
KM539_15850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KM539_15860	COG2351	hydroxyisourate hydrolase activity
KM539_15865	COG2072	flavoprotein involved in K transport
KM539_15885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KM539_15930	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KM539_15935	COG3588	fructose-bisphosphate aldolase
KM539_15940	COG0469	pyruvate kinase activity
KM539_15975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM539_16005	COG0640	Transcriptional regulator
KM539_16015	COG0725	ABC transporter, periplasmic molybdate-binding protein
KM539_16020	COG4149	molybdate abc transporter
KM539_16025	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KM539_16050	COG1376	ErfK ybiS ycfS ynhG family protein
KM539_16055	COG0739	heme binding
KM539_16100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM539_16100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM539_16170	COG3634	alkyl hydroperoxide reductase activity
KM539_16175	COG0583	DNA-binding transcription factor activity
KM539_16185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KM539_16205	COG2197	response regulator
KM539_16230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KM539_16235	COG0697	spore germination
KM539_16275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM539_16280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM539_16290	COG2096	Adenosyltransferase
KM539_16300	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KM539_16305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM539_16310	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KM539_16320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KM539_16325	COG2967	ApaG domain
KM539_16330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KM539_16360	COG1704	LemA family
KM539_16365	COG0861	Integral membrane protein TerC family
KM539_16370	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KM539_16380	COG0642	Histidine kinase
KM539_16395	COG4181	ATPase activity
KM539_16400	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KM539_16420	COG4771	TonB-dependent receptor
KM539_16430	COG0667	Aldo Keto reductase
KM539_16435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM539_16455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM539_16475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KM539_16550	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KM539_16560	COG0494	nUDIX hydrolase
KM539_16575	COG0739	heme binding
KM539_16585	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KM539_16590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KM539_16600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KM539_16610	COG1181	Belongs to the D-alanine--D-alanine ligase family
KM539_16620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KM539_16635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KM539_16650	COG3116	cell division
KM539_16655	COG0275	rRNA processing
KM539_16660	COG2001	Belongs to the MraZ family
KM539_16695	COG0792	nuclease activity
KM539_16700	COG1988	membrane-bound metal-dependent
KM539_16705	COG0277	FAD linked oxidase domain protein
KM539_16710	COG0745	RESPONSE REGULATOR receiver
KM539_16715	COG2205	protein histidine kinase activity
KM539_16725	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KM539_16730	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KM539_16755	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KM539_16760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KM539_16765	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KM539_16780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM539_16780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM539_16790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KM539_16815	COG0477	Major facilitator Superfamily
KM539_16820	COG0488	(ABC) transporter
KM539_16825	COG0242	peptide deformylase activity
KM539_16835	COG1960	acyl-CoA dehydrogenase activity
KM539_16845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KM539_16855	COG1696	Membrane protein involved in D-alanine export
KM539_16875	COG1215	transferase activity, transferring glycosyl groups
KM539_16885	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM539_16935	COG2188	Transcriptional regulator
KM539_16945	COG1450	Type ii and iii secretion system protein
KM539_16960	COG3166	PFAM Fimbrial assembly family protein
KM539_16965	COG3156	type II secretion system protein K
KM539_16970	COG4795	General secretion pathway protein
KM539_16975	COG2165	general secretion pathway protein
KM539_16980	COG4970	Tfp pilus assembly protein FimT
KM539_16985	COG2165	general secretion pathway protein
KM539_16990	COG1459	type II secretion system
KM539_16995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KM539_17000	COG1404	Belongs to the peptidase S8 family
KM539_17005	COG5295	Hep Hag repeat protein
KM539_17010	COG0047	phosphoribosylformylglycinamidine synthase activity
KM539_17010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KM539_17015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KM539_17020	COG4974	Belongs to the 'phage' integrase family
KM539_17045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KM539_17055	COG0525	valine-tRNA ligase activity
KM539_17080	COG1183	phosphatidylcholine synthase activity
KM539_17090	COG0442	prolyl-tRNA aminoacylation
KM539_17105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KM539_17110	COG1127	ABC transporter
KM539_17115	COG3218	ABC-type transport auxiliary lipoprotein component
KM539_17115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KM539_17145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KM539_17150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KM539_17155	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KM539_17155	COG0662	Cupin 2, conserved barrel domain protein
KM539_17180	COG2086	electron transfer activity
KM539_17195	COG0546	phosphoglycolate phosphatase activity
KM539_17195	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KM539_17200	COG0277	FAD linked oxidase domain protein
KM539_17205	COG0300	oxidoreductase activity
KM539_17230	COG0493	'glutamate synthase
KM539_17250	COG0438	transferase activity, transferring glycosyl groups
KM539_17250	COG1216	Glycosyl transferase, family 2
KM539_17255	COG0438	transferase activity, transferring glycosyl groups
KM539_17255	COG1216	Glycosyl transferase, family 2
KM539_17275	COG0626	cystathionine gamma-synthase activity
KM539_17305	COG0625	glutathione transferase activity
KM539_17315	COG0513	Belongs to the DEAD box helicase family
KM539_17320	COG0720	synthase
KM539_17330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KM539_17335	COG1956	GAF domain-containing protein
KM539_17345	COG4206	TonB-dependent receptor
KM539_17350	COG0546	phosphoglycolate phosphatase activity
KM539_17375	COG0339	signal peptide processing
KM539_17380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM539_17390	COG2217	Heavy metal translocating P-type atpase
KM539_17405	COG2132	Multicopper oxidase
KM539_17430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KM539_17440	COG1136	(ABC) transporter
KM539_17445	COG0577	efflux transmembrane transporter activity
KM539_17450	COG0577	efflux transmembrane transporter activity
KM539_17455	COG0577	efflux transmembrane transporter activity
KM539_17460	COG0577	efflux transmembrane transporter activity
KM539_17465	COG0577	efflux transmembrane transporter activity
KM539_17465	COG1136	(ABC) transporter
KM539_17470	COG0577	efflux transmembrane transporter activity
KM539_17485	COG4191	Histidine kinase
KM539_17495	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KM539_17510	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KM539_17525	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KM539_17535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KM539_17545	COG0356	it plays a direct role in the translocation of protons across the membrane
KM539_17560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM539_17565	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM539_17600	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM539_17605	COG0697	spore germination
KM539_17610	COG1666	GTP binding
KM539_17620	COG1187	pseudouridine synthase activity
KM539_17645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM539_17645	COG2205	protein histidine kinase activity
KM539_17670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM539_17760	COG0842	Transport permease protein
KM539_17765	COG1131	(ABC) transporter
KM539_17770	COG0025	NhaP-type Na H and K H
KM539_17780	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
KM539_17785	COG1573	uracil-dna glycosylase
KM539_17800	COG3384	dioxygenase
KM539_17820	COG0667	Aldo Keto reductase
KM539_17825	COG0667	Aldo Keto reductase
KM539_17835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM539_17840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM539_17860	COG3706	GGDEF domain
KM539_17870	COG5001	Diguanylate cyclase
KM539_17900	COG4106	trans-aconitate 2-methyltransferase activity
KM539_17910	COG2076	Multidrug Resistance protein
KM539_17920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KM539_17940	COG3279	Response regulator of the LytR AlgR family
KM539_17945	COG3275	phosphorelay sensor kinase activity
KM539_17970	COG0531	amino acid
KM539_17995	COG4974	Belongs to the 'phage' integrase family
KM539_18095	COG0366	Alpha amylase catalytic
KM539_18100	COG0366	Alpha amylase catalytic
KM539_18115	COG1609	Transcriptional regulator
KM539_18135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM539_18140	COG1490	D-aminoacyl-tRNA deacylase activity
KM539_18155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KM539_18175	COG1215	transferase activity, transferring glycosyl groups
KM539_18190	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KM539_18195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KM539_18195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KM539_18200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KM539_18205	COG0242	peptide deformylase activity
KM539_18210	COG1652	LysM domain
KM539_18230	COG1714	RDD family
KM539_18235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM539_18235	COG1754	DNA topoisomerase type I activity
KM539_18240	COG0009	L-threonylcarbamoyladenylate synthase
KM539_18255	COG1028	Short-chain dehydrogenase reductase Sdr
KM539_18265	COG0616	signal peptide processing
KM539_18270	COG0534	Mate efflux family protein
KM539_18285	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KM539_18295	COG1252	NADH dehydrogenase
KM539_18300	COG2860	membrane
KM539_18305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM539_18310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KM539_18315	COG2201	protein-glutamate methylesterase activity
KM539_18320	COG2177	Part of the ABC transporter FtsEX involved in
KM539_18325	COG2884	Cell division ATP-binding protein ftsE
KM539_18335	COG3118	belongs to the thioredoxin family
KM539_18340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KM539_18390	COG1518	maintenance of DNA repeat elements
KM539_18395	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KM539_18410	COG1652	LysM domain
KM539_18425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM539_18430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM539_18435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM539_18445	COG5383	Protein conserved in bacteria
KM539_18480	COG3501	Rhs element vgr protein
KM539_18480	COG3409	Peptidoglycan-binding domain 1 protein
KM539_18510	COG3023	N-Acetylmuramoyl-L-alanine amidase
KM539_18515	COG4771	TonB-dependent receptor
KM539_18535	COG0531	amino acid
KM539_18560	COG2133	pyrroloquinoline quinone binding
KM539_18575	COG2308	Evidence 4 Homologs of previously reported genes of
KM539_18580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KM539_18600	COG1295	ribonuclease BN
KM539_18605	COG0358	DNA primase activity
KM539_18655	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
KM539_18660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KM539_18665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KM539_18665	COG1565	acr, cog1565
KM539_18680	COG1486	melibiose metabolic process
KM539_18685	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KM539_18685	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KM539_18690	COG0531	amino acid
KM539_18725	COG0793	Belongs to the peptidase S41A family
KM539_18730	COG4942	peptidase
KM539_18740	COG2234	aminopeptidase activity
KM539_18745	COG1064	alcohol dehydrogenase
KM539_18775	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KM539_18780	COG0739	heme binding
KM539_18785	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KM539_18795	COG2814	Major facilitator Superfamily
KM539_18805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KM539_18825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM539_18845	COG4221	oxidoreductase activity
KM539_18865	COG0583	DNA-binding transcription factor activity
KM539_18870	COG2755	lipolytic protein G-D-S-L family
KM539_18870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KM539_18880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KM539_18885	COG1166	arginine decarboxylase activity
KM539_18910	COG2960	long-chain fatty acid transporting porin activity
KM539_18980	COG0210	DNA helicase
KM539_19080	COG2267	carboxylic ester hydrolase activity
KM539_19095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM539_19105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KM539_19145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KM539_19170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM539_19175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KM539_19190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KM539_19200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KM539_19205	COG1522	sequence-specific DNA binding
KM539_19240	COG0714	Associated with various cellular activities
KM539_19250	COG0754	glutathionylspermidine amidase activity
KM539_19255	COG5463	Belongs to the UPF0441 family
KM539_19325	COG2133	pyrroloquinoline quinone binding
KM539_19340	COG0628	permease
KM539_19355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM539_19410	COG1199	ATP-dependent helicase activity
KM539_19485	COG0625	glutathione transferase activity
KM539_19505	COG4555	ABC transporter
KM539_19515	COG1476	TRANSCRIPTIONal
KM539_19525	COG0633	Ferredoxin
KM539_19525	COG0543	2 iron, 2 sulfur cluster binding
KM539_19530	COG1131	(ABC) transporter
KM539_19535	COG0842	Transport permease protein
KM539_19575	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KM539_19585	COG0697	spore germination
KM539_19590	COG0523	cobalamin synthesis protein
KM539_19600	COG1742	UPF0060 membrane protein
KM539_19610	COG3245	cytochrome
KM539_19620	COG1960	acyl-CoA dehydrogenase activity
KM539_19625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KM539_19650	COG1278	Cold shock
KM539_19665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM539_19670	COG3387	PFAM Glycoside hydrolase 15-related
KM539_19675	COG0745	RESPONSE REGULATOR receiver
KM539_19690	COG1404	Belongs to the peptidase S8 family
KM539_19700	COG3100	YcgL domain-containing protein
KM539_19705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KM539_19715	COG0463	Glycosyl transferase, family 2
KM539_19750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KM539_19765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM539_19805	COG1294	oxidase, subunit
KM539_19810	COG1271	oxidase subunit
KM539_19830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM539_19835	COG0408	coproporphyrinogen oxidase activity
KM539_19845	COG2323	membrane
KM539_19850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM539_19850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM539_19865	COG0589	response to stress
KM539_19895	COG0210	DNA helicase
KM539_19965	COG0463	Glycosyl transferase, family 2
KM539_19975	COG1475	DNA binding
KM539_19980	COG1192	Involved in chromosome partitioning
KM539_19985	COG0357	Ribosomal RNA small subunit methyltransferase G
KM539_19995	COG2091	lysine biosynthetic process via aminoadipic acid
KM539_20020	COG1011	Hydrolase
KM539_20025	COG0477	Major facilitator Superfamily
KM539_20055	COG1971	Probably functions as a manganese efflux pump
KM539_20060	COG2205	protein histidine kinase activity
KM539_20065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM539_20070	COG3459	Glycosyltransferase 36 associated
KM539_20075	COG2211	Major facilitator Superfamily
KM539_20080	COG3265	gluconokinase activity
KM539_20095	COG2911	Protein conserved in bacteria
KM539_20100	COG0729	surface antigen
KM539_20120	COG3132	Protein of unknown function, DUF480
KM539_20205	COG0284	orotidine-5'-phosphate decarboxylase activity
KM539_20225	COG1609	Transcriptional regulator
KM539_20235	COG2937	Belongs to the GPAT DAPAT family
KM539_20290	COG3693	PFAM glycoside hydrolase, family 10
KM539_20295	COG1904	glucuronate isomerase
KM539_20310	COG3386	PFAM SMP-30 Gluconolaconase
KM539_20330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM539_20350	COG0246	Mannitol dehydrogenase
KM539_20355	COG1472	Belongs to the glycosyl hydrolase 3 family
KM539_20365	COG4948	Mandelate Racemase Muconate Lactonizing
KM539_20375	COG3661	Belongs to the glycosyl hydrolase 67 family
KM539_20385	COG2115	Belongs to the xylose isomerase family
KM539_20390	COG0037	tRNA processing
KM539_20410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM539_20420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KM539_20430	COG0805	protein transport
KM539_20440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KM539_20440	COG0519	Catalyzes the synthesis of GMP from XMP
KM539_20445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KM539_20465	COG0210	DNA helicase
KM539_20470	COG1435	thymidine kinase activity
KM539_20485	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
KM539_20500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KM539_20515	COG1119	ATPase activity
KM539_20530	COG0706	membrane insertase activity
KM539_20535	COG0594	ribonuclease P activity