locus-tag	class	description
ISN30_00035	COG0366	Alpha amylase catalytic
ISN30_00040	COG0366	Alpha amylase catalytic
ISN30_00050	COG1609	Transcriptional regulator
ISN30_00080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN30_00085	COG1490	D-aminoacyl-tRNA deacylase activity
ISN30_00100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISN30_00125	COG3307	-O-antigen
ISN30_00135	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ISN30_00140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISN30_00140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN30_00145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISN30_00150	COG0242	peptide deformylase activity
ISN30_00155	COG1652	LysM domain
ISN30_00160	COG0758	DNA mediated transformation
ISN30_00175	COG1714	RDD family
ISN30_00180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN30_00180	COG1754	DNA topoisomerase type I activity
ISN30_00185	COG0009	L-threonylcarbamoyladenylate synthase
ISN30_00200	COG1028	Short-chain dehydrogenase reductase Sdr
ISN30_00210	COG0616	signal peptide processing
ISN30_00215	COG0534	Mate efflux family protein
ISN30_00225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISN30_00235	COG1252	NADH dehydrogenase
ISN30_00240	COG2860	membrane
ISN30_00245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN30_00250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISN30_00255	COG2201	protein-glutamate methylesterase activity
ISN30_00260	COG2177	Part of the ABC transporter FtsEX involved in
ISN30_00265	COG2884	Cell division ATP-binding protein ftsE
ISN30_00275	COG3118	belongs to the thioredoxin family
ISN30_00280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISN30_00290	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ISN30_00340	COG1518	maintenance of DNA repeat elements
ISN30_00345	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ISN30_00360	COG1652	LysM domain
ISN30_00375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN30_00380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN30_00395	COG5383	Protein conserved in bacteria
ISN30_00430	COG3409	Peptidoglycan-binding domain 1 protein
ISN30_00430	COG3501	Rhs element vgr protein
ISN30_00460	COG4771	TonB-dependent receptor
ISN30_00470	COG4948	Mandelate Racemase Muconate Lactonizing
ISN30_00480	COG0531	amino acid
ISN30_00500	COG2133	pyrroloquinoline quinone binding
ISN30_00515	COG2308	Evidence 4 Homologs of previously reported genes of
ISN30_00535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISN30_00555	COG1295	ribonuclease BN
ISN30_00560	COG0358	DNA primase activity
ISN30_00580	COG0109	protoheme IX farnesyltransferase activity
ISN30_00615	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ISN30_00620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN30_00625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISN30_00625	COG1565	acr, cog1565
ISN30_00645	COG1486	melibiose metabolic process
ISN30_00650	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ISN30_00650	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ISN30_00655	COG0531	amino acid
ISN30_00690	COG0793	Belongs to the peptidase S41A family
ISN30_00695	COG4942	peptidase
ISN30_00705	COG2234	aminopeptidase activity
ISN30_00710	COG1064	alcohol dehydrogenase
ISN30_00740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ISN30_00745	COG0739	heme binding
ISN30_00750	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ISN30_00760	COG2814	Major facilitator Superfamily
ISN30_00770	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ISN30_00790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISN30_00810	COG4221	oxidoreductase activity
ISN30_00830	COG0583	DNA-binding transcription factor activity
ISN30_00835	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN30_00835	COG2755	lipolytic protein G-D-S-L family
ISN30_00840	COG1819	glycosyl
ISN30_00845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN30_00850	COG1166	arginine decarboxylase activity
ISN30_00870	COG2960	long-chain fatty acid transporting porin activity
ISN30_00875	COG0606	chelatase, subunit chli
ISN30_00905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN30_00910	COG1040	competence protein
ISN30_00915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISN30_00950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISN30_00965	COG5001	Diguanylate cyclase
ISN30_00965	COG3706	GGDEF domain
ISN30_00965	COG4251	negative regulation of phosphorylation
ISN30_00965	COG2203	Gaf domain
ISN30_00975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN30_00980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN30_00995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISN30_01010	COG1522	sequence-specific DNA binding
ISN30_01045	COG0714	Associated with various cellular activities
ISN30_01055	COG0754	glutathionylspermidine amidase activity
ISN30_01095	COG2133	pyrroloquinoline quinone binding
ISN30_01105	COG0628	permease
ISN30_01135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN30_01200	COG1199	ATP-dependent helicase activity
ISN30_01275	COG0625	glutathione transferase activity
ISN30_01295	COG4555	ABC transporter
ISN30_01305	COG1476	TRANSCRIPTIONal
ISN30_01315	COG0543	2 iron, 2 sulfur cluster binding
ISN30_01315	COG0633	Ferredoxin
ISN30_01320	COG1131	(ABC) transporter
ISN30_01325	COG0842	Transport permease protein
ISN30_01425	COG0084	hydrolase, TatD family'
ISN30_01430	COG1643	Atp-dependent helicase
ISN30_01440	COG1187	pseudouridine synthase activity
ISN30_01455	COG2130	NADP-dependent
ISN30_01460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN30_01495	COG0659	secondary active sulfate transmembrane transporter activity
ISN30_01530	COG2224	Isocitrate lyase
ISN30_01535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISN30_01540	COG0583	DNA-binding transcription factor activity
ISN30_01560	COG0339	signal peptide processing
ISN30_01580	COG0564	pseudouridine synthase activity
ISN30_01585	COG4232	protein-disulfide reductase activity
ISN30_01600	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN30_01610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN30_01625	COG0318	PFAM AMP-dependent synthetase and ligase
ISN30_01630	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISN30_01640	COG0596	Alpha beta hydrolase
ISN30_01655	COG3177	Filamentation induced by cAMP protein fic
ISN30_01660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN30_01670	COG0612	Peptidase, M16
ISN30_01680	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISN30_01690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ISN30_01695	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ISN30_01735	COG0183	Belongs to the thiolase family
ISN30_01745	COG2032	superoxide dismutase activity
ISN30_01750	COG2032	superoxide dismutase activity
ISN30_01755	COG2204	response regulator
ISN30_01760	COG3852	Histidine kinase
ISN30_01765	COG0004	ammonium transporteR
ISN30_01770	COG0347	Belongs to the P(II) protein family
ISN30_01775	COG0174	glutamine synthetase
ISN30_01780	COG1968	undecaprenyl-diphosphatase activity
ISN30_01785	COG1881	PFAM PEBP family protein
ISN30_01795	COG2267	carboxylic ester hydrolase activity
ISN30_01805	COG2050	protein possibly involved in aromatic compounds catabolism
ISN30_01810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN30_01820	COG2062	phosphohistidine phosphatase, SixA
ISN30_01825	COG1192	Involved in chromosome partitioning
ISN30_01865	COG2271	Major facilitator Superfamily
ISN30_01895	COG1111	helicase
ISN30_01895	COG1205	dead DEAH box helicase
ISN30_01940	COG0067	glutamate synthase
ISN30_01940	COG0069	glutamate synthase activity
ISN30_01940	COG0070	glutamate synthase
ISN30_01945	COG0493	'glutamate synthase
ISN30_01950	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN30_01955	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN30_01960	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN30_01965	COG1803	Methylglyoxal synthase
ISN30_02020	COG2951	lytic endotransglycosylase activity
ISN30_02035	COG0730	response to heat
ISN30_02065	COG0302	gtp cyclohydrolase
ISN30_02070	COG0477	Major facilitator Superfamily
ISN30_02125	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ISN30_02150	COG0537	adenosine 5'-monophosphoramidase activity
ISN30_02170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISN30_02175	COG1074	ATP-dependent DNA helicase activity
ISN30_02180	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISN30_02185	COG1127	ABC transporter
ISN30_02190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN30_02195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN30_02210	COG2853	Lipoprotein
ISN30_02215	COG0386	Belongs to the glutathione peroxidase family
ISN30_02220	COG1322	Protein conserved in bacteria
ISN30_02240	COG4191	Histidine kinase
ISN30_02245	COG4566	intracellular signal transduction
ISN30_02250	COG0531	amino acid
ISN30_02260	COG1929	Belongs to the glycerate kinase type-1 family
ISN30_02295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ISN30_02310	COG0671	phosphoesterase, PA-phosphatase related
ISN30_02325	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISN30_02365	COG1522	sequence-specific DNA binding
ISN30_02370	COG3186	Phenylalanine-4-hydroxylase
ISN30_02385	COG1028	Short-chain dehydrogenase reductase Sdr
ISN30_02390	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ISN30_02400	COG1609	Transcriptional regulator
ISN30_02405	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN30_02420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISN30_02465	COG4771	TonB-dependent receptor
ISN30_02485	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN30_02560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN30_02585	COG2186	Transcriptional regulator
ISN30_02590	COG1304	FMN binding
ISN30_02625	COG1012	belongs to the aldehyde dehydrogenase family
ISN30_02630	COG3284	Transcriptional regulator
ISN30_02640	COG4772	TonB-dependent receptor
ISN30_02655	COG1280	lysine exporter protein (LysE YggA)
ISN30_02670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN30_02680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISN30_02710	COG0501	Belongs to the peptidase M48B family
ISN30_02715	COG1266	CAAX protease self-immunity
ISN30_02720	COG0187	DNA topoisomerase II activity
ISN30_02725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISN30_02730	COG0592	DNA-directed DNA polymerase activity
ISN30_02745	COG0594	ribonuclease P activity
ISN30_02750	COG0706	membrane insertase activity
ISN30_02765	COG1119	ATPase activity
ISN30_02780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ISN30_02795	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ISN30_02805	COG1435	thymidine kinase activity
ISN30_02810	COG0210	DNA helicase
ISN30_02830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN30_02835	COG0519	Catalyzes the synthesis of GMP from XMP
ISN30_02835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN30_02845	COG0805	protein transport
ISN30_02855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISN30_02865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISN30_02885	COG0037	tRNA processing
ISN30_02890	COG2115	Belongs to the xylose isomerase family
ISN30_02900	COG3661	Belongs to the glycosyl hydrolase 67 family
ISN30_02910	COG4948	Mandelate Racemase Muconate Lactonizing
ISN30_02920	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN30_02925	COG0246	Mannitol dehydrogenase
ISN30_02940	COG3046	protein related to deoxyribodipyrimidine photolyase
ISN30_02950	COG3386	PFAM SMP-30 Gluconolaconase
ISN30_02965	COG1904	glucuronate isomerase
ISN30_02970	COG3693	PFAM glycoside hydrolase, family 10
ISN30_02985	COG2211	Major facilitator Superfamily
ISN30_03010	COG2937	Belongs to the GPAT DAPAT family
ISN30_03020	COG1609	Transcriptional regulator
ISN30_03035	COG0284	orotidine-5'-phosphate decarboxylase activity
ISN30_03065	COG3132	Protein of unknown function, DUF480
ISN30_03085	COG0729	surface antigen
ISN30_03090	COG2911	Protein conserved in bacteria
ISN30_03110	COG2211	Major facilitator Superfamily
ISN30_03115	COG3459	Glycosyltransferase 36 associated
ISN30_03120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN30_03130	COG2205	protein histidine kinase activity
ISN30_03135	COG1971	Probably functions as a manganese efflux pump
ISN30_03155	COG0477	Major facilitator Superfamily
ISN30_03180	COG2091	lysine biosynthetic process via aminoadipic acid
ISN30_03190	COG0357	Ribosomal RNA small subunit methyltransferase G
ISN30_03195	COG1192	Involved in chromosome partitioning
ISN30_03200	COG1475	DNA binding
ISN30_03210	COG0463	Glycosyl transferase, family 2
ISN30_03260	COG0210	DNA helicase
ISN30_03285	COG0589	response to stress
ISN30_03300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN30_03300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN30_03305	COG2323	membrane
ISN30_03315	COG0408	coproporphyrinogen oxidase activity
ISN30_03335	COG1271	oxidase subunit
ISN30_03340	COG1294	oxidase, subunit
ISN30_03365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN30_03380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISN30_03415	COG0463	Glycosyl transferase, family 2
ISN30_03425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISN30_03430	COG3100	YcgL domain-containing protein
ISN30_03440	COG1404	Belongs to the peptidase S8 family
ISN30_03455	COG0745	RESPONSE REGULATOR receiver
ISN30_03460	COG3387	PFAM Glycoside hydrolase 15-related
ISN30_03465	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN30_03480	COG1278	Cold shock
ISN30_03495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISN30_03500	COG1960	acyl-CoA dehydrogenase activity
ISN30_03510	COG3245	cytochrome
ISN30_03520	COG1742	UPF0060 membrane protein
ISN30_03530	COG0523	cobalamin synthesis protein
ISN30_03535	COG0697	spore germination
ISN30_03545	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISN30_03550	COG1846	Transcriptional regulator
ISN30_03555	COG1764	response to oxidative stress
ISN30_03565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN30_03570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN30_03585	COG0583	DNA-binding transcription factor activity
ISN30_03590	COG2814	Major facilitator Superfamily
ISN30_03600	COG1902	pentaerythritol trinitrate reductase activity
ISN30_03605	COG2084	Dehydrogenase
ISN30_03630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN30_03660	COG3228	Belongs to the MtfA family
ISN30_03670	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ISN30_03670	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ISN30_03675	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ISN30_03710	COG0180	Tryptophanyl-tRNA synthetase
ISN30_03725	COG0697	spore germination
ISN30_03745	COG0577	efflux transmembrane transporter activity
ISN30_03750	COG1136	(ABC) transporter
ISN30_03775	COG0753	catalase activity
ISN30_03780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN30_03785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN30_03810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN30_03895	COG0823	Involved in the tonB-independent uptake of proteins
ISN30_03895	COG1506	peptidase
ISN30_03915	COG4773	Receptor
ISN30_03935	COG4807	Protein conserved in bacteria
ISN30_03950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISN30_03980	COG1028	Short-chain dehydrogenase reductase Sdr
ISN30_03985	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN30_03990	COG4948	Mandelate Racemase Muconate Lactonizing
ISN30_04000	COG3254	rhamnose metabolic process
ISN30_04005	COG0738	Major facilitator superfamily
ISN30_04010	COG1414	Transcriptional regulator
ISN30_04040	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
ISN30_04055	COG1802	Transcriptional regulator
ISN30_04070	COG1595	DNA-templated transcription, initiation
ISN30_04090	COG3321	synthase
ISN30_04090	COG1028	Short-chain dehydrogenase reductase Sdr
ISN30_04090	COG0604	alcohol dehydrogenase
ISN30_04095	COG1196	nuclear chromosome segregation
ISN30_04095	COG3264	Mechanosensitive ion channel
ISN30_04115	COG2354	Protein conserved in bacteria
ISN30_04145	COG0513	Belongs to the DEAD box helicase family
ISN30_04150	COG3227	Zinc metalloprotease (Elastase)
ISN30_04165	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN30_04180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISN30_04200	COG3104	oligopeptide transport
ISN30_04220	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ISN30_04235	COG0530	calcium, potassium:sodium antiporter activity
ISN30_04240	COG1320	monovalent cation:proton antiporter activity
ISN30_04245	COG2212	antiporter activity
ISN30_04250	COG1863	multisubunit Na H antiporter MnhE subunit
ISN30_04255	COG0651	ATP synthesis coupled electron transport
ISN30_04260	COG1006	Multisubunit Na H antiporter MnhC subunit
ISN30_04265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISN30_04265	COG2111	Na H antiporter
ISN30_04270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN30_04285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISN30_04300	COG1597	lipid kinase activity
ISN30_04320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISN30_04325	COG0134	indole-3-glycerol-phosphate synthase activity
ISN30_04335	COG0730	response to heat
ISN30_04340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN30_04345	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ISN30_04360	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ISN30_04390	COG2906	2 iron, 2 sulfur cluster binding
ISN30_04430	COG2816	NAD+ diphosphatase activity
ISN30_04470	COG2814	Major facilitator Superfamily
ISN30_04475	COG1289	transmembrane transporter activity
ISN30_04480	COG0151	Belongs to the GarS family
ISN30_04485	COG0138	bifunctional purine biosynthesis protein purh
ISN30_04490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN30_04495	COG2267	carboxylic ester hydrolase activity
ISN30_04515	COG4589	Belongs to the CDS family
ISN30_04520	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISN30_04545	COG2264	protein methyltransferase activity
ISN30_04560	COG0439	Biotin carboxylase
ISN30_04565	COG0511	ligase activity, forming carbon-carbon bonds
ISN30_04570	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ISN30_04580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN30_04585	COG4232	protein-disulfide reductase activity
ISN30_04590	COG1324	tolerance protein
ISN30_04605	COG0459	protein refolding
ISN30_04610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISN30_04630	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ISN30_04645	COG0584	glycerophosphoryl diester phosphodiesterase
ISN30_04670	COG2353	YceI-like domain
ISN30_04685	COG0840	transmembrane signaling receptor activity
ISN30_04885	COG2267	carboxylic ester hydrolase activity
ISN30_04910	COG0697	spore germination
ISN30_04915	COG1113	amino acid transport
ISN30_04920	COG0598	Magnesium transport protein CorA
ISN30_04930	COG2207	Transcriptional regulator
ISN30_04950	COG0741	lytic transglycosylase activity
ISN30_04965	COG5297	Belongs to the glycosyl hydrolase family 6
ISN30_04965	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN30_04975	COG0531	amino acid
ISN30_04995	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ISN30_05000	COG3275	phosphorelay sensor kinase activity
ISN30_05045	COG2076	Multidrug Resistance protein
ISN30_05055	COG4106	trans-aconitate 2-methyltransferase activity
ISN30_05085	COG5001	Diguanylate cyclase
ISN30_05095	COG3706	GGDEF domain
ISN30_05115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN30_05120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN30_05130	COG0667	Aldo Keto reductase
ISN30_05150	COG3384	dioxygenase
ISN30_05165	COG1573	uracil-dna glycosylase
ISN30_05170	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISN30_05180	COG0025	NhaP-type Na H and K H
ISN30_05185	COG1131	(ABC) transporter
ISN30_05190	COG0842	Transport permease protein
ISN30_05250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN30_05275	COG2205	protein histidine kinase activity
ISN30_05275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISN30_05300	COG1187	pseudouridine synthase activity
ISN30_05310	COG1666	GTP binding
ISN30_05315	COG0697	spore germination
ISN30_05320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISN30_05355	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN30_05360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISN30_05375	COG0356	it plays a direct role in the translocation of protons across the membrane
ISN30_05385	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISN30_05395	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISN30_05410	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISN30_05430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISN30_05440	COG4191	Histidine kinase
ISN30_05450	COG1136	(ABC) transporter
ISN30_05450	COG0577	efflux transmembrane transporter activity
ISN30_05455	COG1136	(ABC) transporter
ISN30_05455	COG0577	efflux transmembrane transporter activity
ISN30_05460	COG1136	(ABC) transporter
ISN30_05470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN30_05485	COG2132	Multicopper oxidase
ISN30_05500	COG2217	Heavy metal translocating P-type atpase
ISN30_05515	COG0339	signal peptide processing
ISN30_05540	COG0546	phosphoglycolate phosphatase activity
ISN30_05545	COG4206	TonB-dependent receptor
ISN30_05555	COG1956	GAF domain-containing protein
ISN30_05560	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISN30_05570	COG0720	synthase
ISN30_05575	COG0513	Belongs to the DEAD box helicase family
ISN30_05585	COG0625	glutathione transferase activity
ISN30_05615	COG0626	cystathionine gamma-synthase activity
ISN30_05630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN30_05635	COG0438	transferase activity, transferring glycosyl groups
ISN30_05635	COG1216	Glycosyl transferase, family 2
ISN30_05640	COG1216	Glycosyl transferase, family 2
ISN30_05640	COG0438	transferase activity, transferring glycosyl groups
ISN30_05680	COG0493	'glutamate synthase
ISN30_05695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN30_05700	COG0300	oxidoreductase activity
ISN30_05705	COG0277	FAD linked oxidase domain protein
ISN30_05710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ISN30_05710	COG0546	phosphoglycolate phosphatase activity
ISN30_05725	COG2086	electron transfer activity
ISN30_05750	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ISN30_05750	COG0662	Cupin 2, conserved barrel domain protein
ISN30_05755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISN30_05760	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISN30_05790	COG3218	ABC-type transport auxiliary lipoprotein component
ISN30_05790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN30_05795	COG1127	ABC transporter
ISN30_05800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN30_05815	COG0442	prolyl-tRNA aminoacylation
ISN30_05825	COG1183	phosphatidylcholine synthase activity
ISN30_05855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN30_05880	COG4974	Belongs to the 'phage' integrase family
ISN30_05885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN30_05890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISN30_05890	COG0047	phosphoribosylformylglycinamidine synthase activity
ISN30_05895	COG0840	transmembrane signaling receptor activity
ISN30_05905	COG5295	Hep Hag repeat protein
ISN30_05910	COG1404	Belongs to the peptidase S8 family
ISN30_05915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN30_05920	COG1459	type II secretion system
ISN30_05925	COG2165	general secretion pathway protein
ISN30_05930	COG4970	Tfp pilus assembly protein FimT
ISN30_05935	COG2165	general secretion pathway protein
ISN30_05940	COG4795	General secretion pathway protein
ISN30_05945	COG3156	type II secretion system protein K
ISN30_05950	COG3166	PFAM Fimbrial assembly family protein
ISN30_05965	COG1450	Type ii and iii secretion system protein
ISN30_05975	COG2188	Transcriptional regulator
ISN30_06035	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISN30_06045	COG1215	transferase activity, transferring glycosyl groups
ISN30_06075	COG0242	peptide deformylase activity
ISN30_06080	COG0488	(ABC) transporter
ISN30_06100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISN30_06110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN30_06110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN30_06125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ISN30_06130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN30_06135	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISN30_06155	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ISN30_06160	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ISN30_06170	COG2205	protein histidine kinase activity
ISN30_06175	COG0745	RESPONSE REGULATOR receiver
ISN30_06180	COG0277	FAD linked oxidase domain protein
ISN30_06190	COG0792	nuclease activity
ISN30_06225	COG2001	Belongs to the MraZ family
ISN30_06230	COG0275	rRNA processing
ISN30_06235	COG3116	cell division
ISN30_06250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISN30_06265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISN30_06275	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN30_06280	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISN30_06290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISN30_06295	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ISN30_06305	COG0739	heme binding
ISN30_06370	COG0494	nUDIX hydrolase
ISN30_06380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISN30_06445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISN30_06470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN30_06490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISN30_06495	COG0667	Aldo Keto reductase
ISN30_06505	COG4771	TonB-dependent receptor
ISN30_06525	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISN30_06530	COG4181	ATPase activity
ISN30_06545	COG0642	Histidine kinase
ISN30_06555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISN30_06560	COG0861	Integral membrane protein TerC family
ISN30_06565	COG1704	LemA family
ISN30_06600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ISN30_06605	COG2967	ApaG domain
ISN30_06610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN30_06615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISN30_06620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISN30_06635	COG2096	Adenosyltransferase
ISN30_06645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN30_06650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN30_06690	COG0697	spore germination
ISN30_06695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISN30_06725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISN30_06740	COG0583	DNA-binding transcription factor activity
ISN30_06745	COG3634	alkyl hydroperoxide reductase activity
ISN30_06845	COG0488	(ABC) transporter
ISN30_06885	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISN30_06890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ISN30_06905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ISN30_06915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISN30_06925	COG0193	aminoacyl-tRNA hydrolase activity
ISN30_06930	COG0012	GTP binding
ISN30_06950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN30_06960	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISN30_06965	COG0250	Participates in transcription elongation, termination and antitermination
ISN30_06970	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ISN30_06985	COG0222	ribosome binding
ISN30_06995	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ISN30_07010	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISN30_07015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN30_07020	COG0051	transcription antitermination factor activity, RNA binding
ISN30_07030	COG0088	Forms part of the polypeptide exit tunnel
ISN30_07035	COG0089	rRNA binding
ISN30_07040	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISN30_07065	COG0255	Belongs to the universal ribosomal protein uL29 family
ISN30_07070	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISN30_07080	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ISN30_07085	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISN30_07090	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ISN30_07115	COG1841	ribosomal large subunit assembly
ISN30_07125	COG0201	protein transport
ISN30_07150	COG0203	ribosomal protein L17
ISN30_07155	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ISN30_07165	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ISN30_07180	COG1217	gtp-binding protein TYPA
ISN30_07185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISN30_07195	COG0039	L-malate dehydrogenase activity
ISN30_07205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ISN30_07210	COG0625	glutathione transferase activity
ISN30_07255	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISN30_07255	COG1902	pentaerythritol trinitrate reductase activity
ISN30_07265	COG0667	Aldo Keto reductase
ISN30_07285	COG2885	chlorophyll binding
ISN30_07305	COG0156	8-amino-7-oxononanoate synthase activity
ISN30_07310	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISN30_07315	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISN30_07320	COG4208	sulfate ABC transporter
ISN30_07325	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISN30_07345	COG0588	phosphoglycerate mutase activity
ISN30_07350	COG0285	dihydrofolate synthase activity
ISN30_07370	COG2833	Protein of unknown function (DUF455)
ISN30_07375	COG3291	Pkd domain containing protein
ISN30_07385	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN30_07400	COG0438	transferase activity, transferring glycosyl groups
ISN30_07405	COG0248	Ppx GppA phosphatase
ISN30_07410	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISN30_07425	COG4783	chaperone-mediated protein folding
ISN30_07440	COG0473	3-isopropylmalate dehydrogenase activity
ISN30_07485	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISN30_07495	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISN30_07535	COG3942	CHAP domain
ISN30_07535	COG1388	LysM domain
ISN30_07540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN30_07550	COG0328	RNA-DNA hybrid ribonuclease activity
ISN30_07555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN30_07560	COG0631	protein serine/threonine phosphatase activity
ISN30_07580	COG0859	PFAM glycosyl transferase family 9
ISN30_07590	COG1234	tRNA 3'-trailer cleavage
ISN30_07595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISN30_07605	COG0315	cyclic pyranopterin monophosphate synthase activity
ISN30_07610	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISN30_07615	COG0314	molybdopterin synthase activity
ISN30_07645	COG0537	adenosine 5'-monophosphoramidase activity
ISN30_07665	COG0714	Associated with various cellular activities
ISN30_07690	COG1399	metal-binding, possibly nucleic acid-binding protein
ISN30_07700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN30_07705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISN30_07710	COG1028	Short-chain dehydrogenase reductase Sdr
ISN30_07715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN30_07725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISN30_07730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISN30_07735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ISN30_07755	COG4115	mRNA cleavage
ISN30_07760	COG2161	toxin-antitoxin pair type II binding
ISN30_07785	COG0372	Belongs to the citrate synthase family
ISN30_07800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISN30_07855	COG2373	Large extracellular alpha-helical protein
ISN30_07875	COG4953	penicillin-binding protein 1C
ISN30_07885	COG0678	peroxiredoxin activity
ISN30_07910	COG0604	alcohol dehydrogenase
ISN30_07915	COG0330	HflC and HflK could
ISN30_07920	COG0330	HflC and HflK could
ISN30_07930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISN30_08065	COG3459	Glycosyltransferase 36 associated
ISN30_08075	COG1063	alcohol dehydrogenase
ISN30_08095	COG4106	trans-aconitate 2-methyltransferase activity
ISN30_08110	COG0753	catalase activity
ISN30_08120	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN30_08120	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN30_08145	COG2814	Major facilitator Superfamily
ISN30_08225	COG2194	sulfuric ester hydrolase activity
ISN30_08235	COG0745	RESPONSE REGULATOR receiver
ISN30_08240	COG2205	protein histidine kinase activity
ISN30_08250	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISN30_08255	COG2894	cell division
ISN30_08260	COG0850	regulation of cytokinetic process
ISN30_08270	COG4585	Histidine kinase
ISN30_08295	COG1216	Glycosyl transferase, family 2
ISN30_08300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN30_08310	COG1199	ATP-dependent helicase activity
ISN30_08330	COG0189	ligase activity
ISN30_08345	COG0835	chemotaxis
ISN30_08350	COG0840	transmembrane signaling receptor activity
ISN30_08355	COG0784	Response regulator, receiver
ISN30_08355	COG2198	Histidine kinase
ISN30_08355	COG0643	Histidine kinase
ISN30_08360	COG2201	protein-glutamate methylesterase activity
ISN30_08390	COG1446	asparaginase
ISN30_08395	COG3142	Participates in the control of copper homeostasis
ISN30_08435	COG0217	transcriptional regulatory protein
ISN30_08445	COG0632	four-way junction helicase activity
ISN30_08450	COG3158	transport of potassium into the cell
ISN30_08455	COG2255	four-way junction helicase activity
ISN30_08460	COG0824	Thioesterase
ISN30_08470	COG0848	biopolymer transport protein
ISN30_08485	COG2885	chlorophyll binding
ISN30_08495	COG0602	queuosine metabolic process
ISN30_08500	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ISN30_08520	COG0514	ATP-dependent DNA helicase (RecQ)
ISN30_08525	COG0783	Belongs to the Dps family
ISN30_08530	COG1643	Atp-dependent helicase
ISN30_08580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN30_08605	COG1073	alpha beta
ISN30_08645	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ISN30_08660	COG1946	Acyl-CoA thioesterase
ISN30_08665	COG1024	Enoyl-CoA hydratase
ISN30_08675	COG0824	Thioesterase
ISN30_08680	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISN30_08685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISN30_08690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISN30_08700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ISN30_08710	COG0728	peptidoglycan biosynthetic process
ISN30_08730	COG0196	riboflavin kinase activity
ISN30_08745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ISN30_08775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN30_08780	COG1845	cytochrome c oxidase, subunit III
ISN30_08785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISN30_08795	COG0156	8-amino-7-oxononanoate synthase activity
ISN30_08805	COG3152	Membrane
ISN30_08820	COG1595	DNA-templated transcription, initiation
ISN30_08845	COG0745	RESPONSE REGULATOR receiver
ISN30_08875	COG4794	Type iii secretion
ISN30_08900	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISN30_08945	COG2207	Transcriptional regulator
ISN30_08975	COG0129	dihydroxy-acid dehydratase activity
ISN30_08995	COG1012	belongs to the aldehyde dehydrogenase family
ISN30_09000	COG1879	ABC-type sugar transport system periplasmic component
ISN30_09005	COG1129	ABC transporter
ISN30_09010	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN30_09015	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN30_09025	COG1082	Xylose isomerase domain protein TIM barrel
ISN30_09030	COG0625	glutathione transferase activity
ISN30_09040	COG0475	glutathione-regulated potassium exporter activity
ISN30_09065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISN30_09070	COG2070	2-Nitropropane dioxygenase
ISN30_09080	COG0228	four-way junction DNA binding
ISN30_09085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISN30_09090	COG0336	Belongs to the RNA methyltransferase TrmD family
ISN30_09095	COG0335	large ribosomal subunit rRNA binding
ISN30_09100	COG0534	Mate efflux family protein
ISN30_09110	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISN30_09130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISN30_09145	COG2855	membrane
ISN30_09165	COG1024	Enoyl-CoA hydratase
ISN30_09165	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN30_09180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN30_09185	COG0481	GTPase activity
ISN30_09190	COG0681	Belongs to the peptidase S26 family
ISN30_09205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISN30_09210	COG1381	Involved in DNA repair and RecF pathway recombination
ISN30_09225	COG2954	triphosphatase activity
ISN30_09235	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN30_09240	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISN30_09245	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ISN30_09250	COG1278	Cold shock
ISN30_09255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN30_09265	COG1201	RNA secondary structure unwinding
ISN30_09270	COG1793	dna ligase
ISN30_09270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN30_09275	COG1793	dna ligase
ISN30_09275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN30_09305	COG0443	Heat shock 70 kDa protein
ISN30_09315	COG0183	Belongs to the thiolase family
ISN30_09345	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN30_09345	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN30_09345	COG1703	isobutyryl-CoA mutase activity
ISN30_09410	COG3250	beta-galactosidase activity
ISN30_09415	COG2186	Transcriptional regulator
ISN30_09425	COG2198	Histidine kinase
ISN30_09425	COG2205	protein histidine kinase activity
ISN30_09425	COG0784	Response regulator, receiver
ISN30_09445	COG1451	nucleotide metabolic process
ISN30_09455	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISN30_09490	COG1077	Cell shape determining protein MreB Mrl
ISN30_09495	COG1047	Peptidyl-prolyl cis-trans
ISN30_09500	COG2824	Alkylphosphonate utilization operon protein PhnA
ISN30_09505	COG1902	pentaerythritol trinitrate reductase activity
ISN30_09510	COG2814	Major facilitator Superfamily
ISN30_09540	COG0392	lysyltransferase activity
ISN30_09540	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ISN30_09550	COG0251	oxidation-reduction process
ISN30_09575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISN30_09600	COG1595	DNA-templated transcription, initiation
ISN30_09615	COG2878	Part of a membrane complex involved in electron transport
ISN30_09635	COG0346	lactoylglutathione lyase activity
ISN30_09645	COG0833	amino acid
ISN30_09650	COG2040	homocysteine
ISN30_09660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISN30_09675	COG3118	belongs to the thioredoxin family
ISN30_09685	COG0495	leucyl-tRNA aminoacylation
ISN30_09700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ISN30_09715	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISN30_09730	COG2968	Membrane
ISN30_09750	COG0312	modulator of DNA gyrase
ISN30_09760	COG0312	modulator of DNA gyrase
ISN30_09850	COG0631	protein serine/threonine phosphatase activity
ISN30_09855	COG2815	serine threonine protein kinase
ISN30_09855	COG0515	serine threonine protein kinase
ISN30_09880	COG1858	cytochrome C peroxidase
ISN30_09890	COG0142	geranyltranstransferase activity
ISN30_09895	COG1722	exodeoxyribonuclease VII activity
ISN30_09900	COG0037	tRNA processing
ISN30_09910	COG1785	Belongs to the alkaline phosphatase family
ISN30_09915	COG1301	dicarboxylic acid transport
ISN30_09925	COG1607	acyl-coa hydrolase
ISN30_09940	COG0791	NLP P60 protein
ISN30_09945	COG0791	NLP P60 protein
ISN30_09950	COG1047	Peptidyl-prolyl cis-trans
ISN30_09955	COG2311	Membrane
ISN30_09960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN30_10020	COG3590	peptidase
ISN30_10035	COG0457	Tetratricopeptide repeat
ISN30_10040	COG4771	TonB-dependent receptor
ISN30_10050	COG4771	TonB-dependent receptor
ISN30_10060	COG0489	protein tyrosine kinase activity
ISN30_10065	COG0717	Belongs to the dCTP deaminase family
ISN30_10070	COG1714	RDD family
ISN30_10090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN30_10105	COG0494	nUDIX hydrolase
ISN30_10110	COG0433	COG0433 Predicted ATPase
ISN30_10115	COG0741	lytic transglycosylase activity
ISN30_10120	COG0688	phosphatidylethanolamine metabolic process
ISN30_10130	COG2890	protein-(glutamine-N5) methyltransferase activity
ISN30_10190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISN30_10220	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN30_10230	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN30_10235	COG0649	NAD binding
ISN30_10240	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ISN30_10245	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ISN30_10285	COG1007	ATP synthesis coupled electron transport
ISN30_10300	COG0195	Participates in both transcription termination and antitermination
ISN30_10325	COG1185	polyribonucleotide nucleotidyltransferase activity
ISN30_10345	COG5001	Diguanylate cyclase
ISN30_10345	COG3300	MHYT domain
ISN30_10365	COG0840	transmembrane signaling receptor activity
ISN30_10370	COG0840	transmembrane signaling receptor activity
ISN30_10375	COG0835	chemotaxis
ISN30_10420	COG1194	a g-specific adenine glycosylase
ISN30_10425	COG0552	protein localization to endoplasmic reticulum
ISN30_10435	COG3938	Belongs to the proline racemase family
ISN30_10440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN30_10455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN30_10465	COG0006	proline dipeptidase activity
ISN30_10480	COG0531	amino acid
ISN30_10505	COG4206	TonB-dependent receptor
ISN30_10515	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN30_10525	COG4771	TonB-dependent receptor
ISN30_10550	COG0742	ribosomal rna small subunit methyltransferase
ISN30_10565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISN30_10570	COG0405	Gamma-glutamyltransferase
ISN30_10575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN30_10580	COG3291	Pkd domain containing protein
ISN30_10585	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ISN30_10595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN30_10605	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISN30_10615	COG1862	Preprotein translocase
ISN30_10620	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN30_10645	COG4251	negative regulation of phosphorylation
ISN30_10645	COG2203	Gaf domain
ISN30_10645	COG3706	GGDEF domain
ISN30_10645	COG5001	Diguanylate cyclase
ISN30_10650	COG1509	lysine 2,3-aminomutase activity
ISN30_10660	COG3548	integral membrane protein
ISN30_10665	COG0402	S-adenosylhomocysteine deaminase activity
ISN30_10720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN30_10750	COG2166	iron-sulfur cluster assembly
ISN30_10765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ISN30_10770	COG0137	argininosuccinate synthase activity
ISN30_10775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN30_10780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISN30_10790	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISN30_10795	COG0165	Argininosuccinate lyase
ISN30_10815	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ISN30_10845	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN30_10855	COG1070	Carbohydrate kinase
ISN30_10865	COG0477	Major facilitator Superfamily
ISN30_10870	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN30_10890	COG0617	tRNA 3'-terminal CCA addition
ISN30_10900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ISN30_10915	COG0166	Belongs to the GPI family
ISN30_10935	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ISN30_10950	COG0671	phosphoesterase, PA-phosphatase related
ISN30_10975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISN30_10980	COG0167	dihydroorotate dehydrogenase activity
ISN30_10995	COG1012	belongs to the aldehyde dehydrogenase family
ISN30_11010	COG0527	aspartate kinase activity
ISN30_11010	COG0460	homoserine dehydrogenase
ISN30_11020	COG2951	lytic endotransglycosylase activity
ISN30_11030	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISN30_11040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN30_11045	COG0124	histidyl-tRNA synthetase
ISN30_11055	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ISN30_11060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISN30_11065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN30_11075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISN30_11090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISN30_11090	COG0140	phosphoribosyl-ATP diphosphatase activity
ISN30_11105	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
ISN30_11110	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ISN30_11120	COG0531	amino acid
ISN30_11125	COG0531	amino acid
ISN30_11140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISN30_11145	COG0277	FAD linked oxidase domain protein
ISN30_11165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISN30_11180	COG1024	Enoyl-CoA hydratase
ISN30_11220	COG1741	Belongs to the pirin family
ISN30_11225	COG0583	DNA-binding transcription factor activity
ISN30_11245	COG0351	phosphomethylpyrimidine kinase
ISN30_11260	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ISN30_11265	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISN30_11275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN30_11285	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ISN30_11290	COG3734	2-keto-3-deoxy-galactonokinase
ISN30_11305	COG0800	Aldolase
ISN30_11340	COG2198	Histidine kinase
ISN30_11340	COG0784	Response regulator, receiver
ISN30_11340	COG2205	protein histidine kinase activity
ISN30_11345	COG1024	Enoyl-CoA hydratase
ISN30_11350	COG0318	PFAM AMP-dependent synthetase and ligase
ISN30_11405	COG0840	transmembrane signaling receptor activity
ISN30_11415	COG0840	transmembrane signaling receptor activity
ISN30_11425	COG0835	chemotaxis
ISN30_11435	COG0840	transmembrane signaling receptor activity
ISN30_11445	COG0840	transmembrane signaling receptor activity
ISN30_11450	COG0840	transmembrane signaling receptor activity
ISN30_11455	COG0840	transmembrane signaling receptor activity
ISN30_11465	COG0840	transmembrane signaling receptor activity
ISN30_11475	COG0840	transmembrane signaling receptor activity
ISN30_11480	COG0840	transmembrane signaling receptor activity
ISN30_11485	COG0840	transmembrane signaling receptor activity
ISN30_11490	COG0840	transmembrane signaling receptor activity
ISN30_11505	COG0745	RESPONSE REGULATOR receiver
ISN30_11520	COG1192	Involved in chromosome partitioning
ISN30_11530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ISN30_11535	COG2198	Histidine kinase
ISN30_11535	COG0784	Response regulator, receiver
ISN30_11535	COG0643	Histidine kinase
ISN30_11540	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISN30_11585	COG1684	flagellar biosynthetic protein fliR
ISN30_11590	COG1987	bacterial-type flagellum assembly
ISN30_11600	COG3190	flagellar
ISN30_11650	COG1677	Flagellar hook-basal body complex protein FliE
ISN30_11695	COG1028	Short-chain dehydrogenase reductase Sdr
ISN30_11700	COG1028	Short-chain dehydrogenase reductase Sdr
ISN30_11705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN30_11725	COG2201	protein-glutamate methylesterase activity
ISN30_11730	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISN30_11735	COG2197	response regulator
ISN30_11755	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ISN30_11760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN30_11765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN30_11770	COG4786	Flagellar basal body rod
ISN30_11770	COG4786	Flagellar basal body rod
ISN30_11770	COG1256	bacterial-type flagellum assembly
ISN30_11770	COG1256	bacterial-type flagellum assembly
ISN30_11785	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ISN30_11800	COG1749	Flagellar hook protein flgE
ISN30_11810	COG1558	bacterial-type flagellum-dependent cell motility
ISN30_11820	COG0784	Response regulator, receiver
ISN30_11820	COG0835	chemotaxis
ISN30_11885	COG2915	High frequency lysogenization protein hflD homolog
ISN30_11890	COG0482	sulfurtransferase activity
ISN30_11910	COG0542	response to heat
ISN30_11920	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ISN30_11930	COG0492	ferredoxin-NADP+ reductase activity
ISN30_11935	COG1674	ftsk spoiiie
ISN30_11955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISN30_11960	COG0038	chloride channel
ISN30_12010	COG1595	DNA-templated transcription, initiation
ISN30_12030	COG3038	cytochrome b561
ISN30_12060	COG2244	polysaccharide biosynthetic process
ISN30_12080	COG4106	trans-aconitate 2-methyltransferase activity
ISN30_12100	COG0438	transferase activity, transferring glycosyl groups
ISN30_12105	COG0438	transferase activity, transferring glycosyl groups
ISN30_12125	COG1132	(ABC) transporter
ISN30_12165	COG1022	Amp-dependent synthetase and ligase
ISN30_12190	COG0512	Glutamine amidotransferase of anthranilate synthase
ISN30_12210	COG2801	Transposase and inactivated derivatives
ISN30_12235	COG1530	ribonuclease E activity
ISN30_12250	COG0428	transporter
ISN30_12265	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISN30_12265	COG0316	Belongs to the HesB IscA family
ISN30_12285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN30_12305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN30_12310	COG2957	Belongs to the agmatine deiminase family
ISN30_12320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISN30_12325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISN30_12330	COG0539	negative regulation of cytoplasmic translation
ISN30_12335	COG0776	regulation of translation
ISN30_12345	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISN30_12350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISN30_12360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISN30_12365	COG0183	Belongs to the thiolase family
ISN30_12370	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN30_12370	COG1024	Enoyl-CoA hydratase
ISN30_12385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISN30_12395	COG1426	Protein conserved in bacteria
ISN30_12405	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN30_12415	COG0746	molybdenum cofactor guanylyltransferase activity
ISN30_12425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISN30_12430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN30_12430	COG0475	glutathione-regulated potassium exporter activity
ISN30_12445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISN30_12455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN30_12455	COG0519	Catalyzes the synthesis of GMP from XMP
ISN30_12515	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN30_12520	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN30_12530	COG1914	H( )-stimulated, divalent metal cation uptake system
ISN30_12545	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISN30_12550	COG0668	transmembrane transport
ISN30_12560	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISN30_12575	COG1028	Short-chain dehydrogenase reductase Sdr
ISN30_12580	COG1183	phosphatidylcholine synthase activity
ISN30_12590	COG3243	poly(R)-hydroxyalkanoic acid synthase
ISN30_12610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN30_12610	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ISN30_12620	COG4191	Histidine kinase
ISN30_12620	COG0784	Response regulator, receiver
ISN30_12625	COG2183	response to ionizing radiation
ISN30_12630	COG0784	Response regulator, receiver
ISN30_12630	COG2205	protein histidine kinase activity
ISN30_12700	COG1649	PFAM Uncharacterised BCR, COG1649
ISN30_12705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN30_12710	COG1304	FMN binding
ISN30_12720	COG0346	lactoylglutathione lyase activity
ISN30_12740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN30_12765	COG1024	Enoyl-CoA hydratase
ISN30_12770	COG1024	Enoyl-CoA hydratase
ISN30_12780	COG1024	Enoyl-CoA hydratase
ISN30_12795	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN30_12800	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN30_12885	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISN30_12895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN30_12900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISN30_12910	COG0505	Belongs to the CarA family
ISN30_12920	COG2258	MOSC domain
ISN30_12925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISN30_12955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN30_12965	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN30_12970	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ISN30_13015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN30_13030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISN30_13040	COG1663	tetraacyldisaccharide 4'-kinase activity
ISN30_13045	COG1132	(ABC) transporter
ISN30_13055	COG0811	peptide transport
ISN30_13080	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISN30_13090	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISN30_13105	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISN30_13110	COG2009	succinate dehydrogenase
ISN30_13125	COG3842	ATPase activity
ISN30_13130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN30_13145	COG0129	dihydroxy-acid dehydratase activity
ISN30_13160	COG0395	ABC-type sugar transport system, permease component
ISN30_13195	COG2350	Protein conserved in bacteria
ISN30_13200	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ISN30_13205	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ISN30_13210	COG1187	pseudouridine synthase activity
ISN30_13235	COG0436	Aminotransferase
ISN30_13240	COG4133	protoheme IX ABC transporter activity
ISN30_13285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN30_13290	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISN30_13295	COG4988	ABC transporter
ISN30_13305	COG1294	oxidase, subunit
ISN30_13365	COG2137	regulation of response to DNA damage stimulus
ISN30_13370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ISN30_13375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISN30_13380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ISN30_13385	COG1546	Belongs to the CinA family
ISN30_13390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISN30_13400	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN30_13405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISN30_13415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN30_13420	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ISN30_13425	COG1534	Rna-binding protein
ISN30_13440	COG1238	metal cluster binding
ISN30_13450	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ISN30_13465	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ISN30_13470	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ISN30_13475	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ISN30_13490	COG0504	CTP synthase activity
ISN30_13510	COG0306	phosphate transporter
ISN30_13520	COG1253	flavin adenine dinucleotide binding
ISN30_13535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISN30_13575	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISN30_13585	COG1609	Transcriptional regulator
ISN30_13590	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN30_13590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN30_13595	COG1105	Belongs to the carbohydrate kinase PfkB family
ISN30_13600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN30_13600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN30_13630	COG1136	(ABC) transporter
ISN30_13630	COG0577	efflux transmembrane transporter activity
ISN30_13670	COG0583	DNA-binding transcription factor activity
ISN30_13695	COG1605	Chorismate mutase
ISN30_13695	COG0077	Prephenate dehydratase
ISN30_13700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ISN30_13705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISN30_13745	COG4221	oxidoreductase activity
ISN30_13760	COG1228	amidohydrolase
ISN30_13775	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISN30_13810	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ISN30_13820	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ISN30_13825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ISN30_13830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN30_13865	COG0316	Belongs to the HesB IscA family
ISN30_13935	COG0288	reversible hydration of carbon dioxide
ISN30_13950	COG3844	kynureninase activity
ISN30_13960	COG2925	Exonuclease
ISN30_14000	COG2201	protein-glutamate methylesterase activity
ISN30_14030	COG2902	Dehydrogenase
ISN30_14040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN30_14045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN30_14075	COG1960	acyl-CoA dehydrogenase activity
ISN30_14080	COG2226	methyltransferase
ISN30_14085	COG1410	methionine synthase
ISN30_14085	COG0646	methionine synthase
ISN30_14090	COG1410	methionine synthase
ISN30_14090	COG0646	methionine synthase
ISN30_14100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN30_14100	COG2755	lipolytic protein G-D-S-L family
ISN30_14110	COG2900	Belongs to the SlyX family
ISN30_14125	COG0386	Belongs to the glutathione peroxidase family
ISN30_14135	COG1725	Transcriptional regulator
ISN30_14140	COG1131	(ABC) transporter
ISN30_14195	COG2850	peptidyl-arginine hydroxylation
ISN30_14205	COG0567	Dehydrogenase, E1 component
ISN30_14250	COG1132	(ABC) transporter
ISN30_14260	COG1605	Chorismate mutase
ISN30_14260	COG0287	Prephenate dehydrogenase
ISN30_14265	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISN30_14275	COG0484	heat shock protein binding
ISN30_14280	COG0443	Heat shock 70 kDa protein
ISN30_14285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISN30_14290	COG1420	regulation of RNA biosynthetic process
ISN30_14295	COG0497	DNA recombination
ISN30_14300	COG0735	belongs to the Fur family
ISN30_14305	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN30_14315	COG2867	negative regulation of translational initiation
ISN30_14320	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ISN30_14330	COG1404	Belongs to the peptidase S8 family
ISN30_14365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN30_14380	COG0583	DNA-binding transcription factor activity
ISN30_14395	COG0415	Belongs to the DNA photolyase family
ISN30_14400	COG0305	Participates in initiation and elongation during chromosome replication
ISN30_14410	COG1960	acyl-CoA dehydrogenase activity
ISN30_14425	COG0084	hydrolase, TatD family'
ISN30_14430	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISN30_14505	COG0386	Belongs to the glutathione peroxidase family
ISN30_14520	COG1846	Transcriptional regulator
ISN30_14560	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN30_14570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISN30_14590	COG0488	(ABC) transporter
ISN30_14595	COG0513	Belongs to the DEAD box helicase family
ISN30_14620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ISN30_14625	COG0657	acetylesterase activity
ISN30_14630	COG0625	glutathione transferase activity
ISN30_14640	COG0564	pseudouridine synthase activity
ISN30_14645	COG4681	YaeQ
ISN30_14650	COG2081	HI0933 family
ISN30_14670	COG1028	Short-chain dehydrogenase reductase Sdr
ISN30_14690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISN30_14695	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN30_14700	COG0802	atpase or kinase
ISN30_14705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISN30_14705	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISN30_14710	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN30_14715	COG1570	exodeoxyribonuclease VII activity
ISN30_14750	COG1960	acyl-CoA dehydrogenase activity
ISN30_14760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISN30_14780	COG0438	transferase activity, transferring glycosyl groups
ISN30_14790	COG0438	transferase activity, transferring glycosyl groups
ISN30_14795	COG0438	transferase activity, transferring glycosyl groups
ISN30_14845	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISN30_14850	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISN30_14860	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ISN30_14970	COG2948	multi-organism process
ISN30_15005	COG0556	nucleotide-excision repair
ISN30_15050	COG3275	phosphorelay sensor kinase activity
ISN30_15055	COG1611	Belongs to the LOG family
ISN30_15065	COG2095	MarC family integral membrane protein
ISN30_15070	COG1028	Short-chain dehydrogenase reductase Sdr
ISN30_15075	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN30_15115	COG2969	positive regulation of protein catabolic process
ISN30_15120	COG0625	glutathione transferase activity
ISN30_15125	COG2857	Cytochrome c1
ISN30_15135	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ISN30_15140	COG0723	plastoquinol--plastocyanin reductase activity
ISN30_15145	COG0741	lytic transglycosylase activity
ISN30_15160	COG1702	phosphate starvation-inducible protein PhoH
ISN30_15175	COG4535	Mg2 and Co2 transporter CorC
ISN30_15190	COG1012	belongs to the aldehyde dehydrogenase family
ISN30_15195	COG1177	transmembrane transport
ISN30_15200	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISN30_15205	COG3842	ATPase activity
ISN30_15225	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISN30_15230	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISN30_15240	COG0174	glutamine synthetase
ISN30_15245	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN30_15250	COG0174	glutamine synthetase
ISN30_15255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN30_15265	COG0477	Major facilitator Superfamily
ISN30_15290	COG0243	molybdopterin cofactor binding
ISN30_15300	COG2223	nitrite transmembrane transporter activity
ISN30_15320	COG1012	belongs to the aldehyde dehydrogenase family
ISN30_15325	COG1917	Cupin 2, conserved barrel domain protein
ISN30_15325	COG1396	sequence-specific DNA binding
ISN30_15330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISN30_15335	COG0686	Belongs to the AlaDH PNT family
ISN30_15355	COG2733	membrane
ISN30_15360	COG0784	Response regulator, receiver
ISN30_15360	COG2205	protein histidine kinase activity
ISN30_15360	COG5002	protein histidine kinase activity
ISN30_15420	COG1024	Enoyl-CoA hydratase
ISN30_15430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISN30_15435	COG0659	secondary active sulfate transmembrane transporter activity
ISN30_15455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN30_15460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN30_15470	COG0581	inorganic phosphate transmembrane transporter activity
ISN30_15480	COG0704	Plays a role in the regulation of phosphate uptake
ISN30_15500	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN30_15510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN30_15520	COG0557	exoribonuclease II activity
ISN30_15555	COG2814	Major facilitator Superfamily
ISN30_15560	COG1566	PFAM secretion protein HlyD family protein
ISN30_15595	COG0367	asparagine synthase
ISN30_15610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN30_15615	COG1393	Belongs to the ArsC family
ISN30_15630	COG0024	Methionine aminopeptidase
ISN30_15670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISN30_15680	COG0528	UMP kinase activity
ISN30_15690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISN30_15695	COG0575	Belongs to the CDS family
ISN30_15700	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISN30_15705	COG0750	zinc metalloprotease
ISN30_15710	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN30_15715	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN30_15725	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN30_15730	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN30_15755	COG1981	membrane
ISN30_15795	COG0583	DNA-binding transcription factor activity
ISN30_15815	COG1132	(ABC) transporter
ISN30_15835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISN30_15860	COG1187	pseudouridine synthase activity
ISN30_15960	COG2080	2 iron, 2 sulfur cluster binding
ISN30_15965	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ISN30_15970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ISN30_16005	COG0735	belongs to the Fur family
ISN30_16010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISN30_16040	COG2205	protein histidine kinase activity
ISN30_16050	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISN30_16055	COG3878	Protein conserved in bacteria
ISN30_16070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISN30_16080	COG0643	Histidine kinase
ISN30_16080	COG2198	Histidine kinase
ISN30_16085	COG0840	transmembrane signaling receptor activity
ISN30_16090	COG0840	transmembrane signaling receptor activity
ISN30_16095	COG0840	transmembrane signaling receptor activity
ISN30_16100	COG0835	chemotaxis
ISN30_16105	COG5001	Diguanylate cyclase
ISN30_16105	COG4251	negative regulation of phosphorylation
ISN30_16105	COG3706	GGDEF domain
ISN30_16105	COG2203	Gaf domain
ISN30_16135	COG2211	Major facilitator Superfamily
ISN30_16150	COG0588	phosphoglycerate mutase activity
ISN30_16175	COG1966	Carbon starvation protein
ISN30_16180	COG2879	small protein
ISN30_16185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN30_16210	COG1506	peptidase
ISN30_16210	COG0823	Involved in the tonB-independent uptake of proteins
ISN30_16215	COG1297	OPT oligopeptide transporter protein
ISN30_16220	COG3104	oligopeptide transport
ISN30_16235	COG3550	peptidyl-serine autophosphorylation
ISN30_16240	COG0629	single-stranded DNA binding
ISN30_16245	COG0142	geranyltranstransferase activity
ISN30_16270	COG0527	aspartate kinase activity
ISN30_16275	COG0384	phenazine biosynthesis protein PhzF
ISN30_16285	COG1764	response to oxidative stress
ISN30_16300	COG0739	heme binding
ISN30_16315	COG0693	protein deglycase activity
ISN30_16330	COG0719	Fe-S assembly protein
ISN30_16335	COG0396	ATPase activity
ISN30_16340	COG0719	Fe-S assembly protein
ISN30_16345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISN30_16355	COG2146	nitrite reductase [NAD(P)H] activity
ISN30_16360	COG4774	siderophore transport
ISN30_16385	COG1477	protein flavinylation
ISN30_16390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN30_16410	COG1555	photosystem II stabilization
ISN30_16425	COG3178	'Phosphotransferase
ISN30_16430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ISN30_16440	COG0628	permease
ISN30_16465	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISN30_16510	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISN30_16525	COG1137	ATPase activity
ISN30_16540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN30_16550	COG1660	Displays ATPase and GTPase activities
ISN30_16560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN30_16565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN30_16570	COG2239	Acts as a magnesium transporter
ISN30_16590	COG1113	amino acid transport
ISN30_16600	COG0840	transmembrane signaling receptor activity
ISN30_16620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISN30_16635	COG0519	Catalyzes the synthesis of GMP from XMP
ISN30_16695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISN30_16710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN30_16715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN30_16725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ISN30_16730	COG2814	Major facilitator Superfamily
ISN30_16750	COG3038	cytochrome b561
ISN30_16765	COG1760	l-serine dehydratase
ISN30_16775	COG2267	carboxylic ester hydrolase activity
ISN30_16780	COG0527	aspartate kinase activity
ISN30_16780	COG0460	homoserine dehydrogenase
ISN30_16785	COG0626	cystathionine gamma-synthase activity
ISN30_16790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN30_16800	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ISN30_16805	COG1272	protein, Hemolysin III
ISN30_16810	COG2982	Protein involved in outer membrane biogenesis
ISN30_16815	COG0517	IMP dehydrogenase activity
ISN30_16820	COG0463	Glycosyl transferase, family 2
ISN30_16825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN30_16830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ISN30_16840	COG4206	TonB-dependent receptor
ISN30_16855	COG1960	acyl-CoA dehydrogenase activity
ISN30_16860	COG1304	FMN binding
ISN30_16870	COG1657	PFAM Prenyltransferase squalene oxidase
ISN30_16875	COG0142	geranyltranstransferase activity
ISN30_16880	COG2124	cytochrome p450
ISN30_16885	COG1028	Short-chain dehydrogenase reductase Sdr
ISN30_16890	COG1141	Ferredoxin
ISN30_16895	COG2124	cytochrome p450
ISN30_16900	COG2124	cytochrome p450
ISN30_16965	COG0330	HflC and HflK could
ISN30_16970	COG1742	UPF0060 membrane protein
ISN30_16975	COG3956	TIGRFAM MazG family protein
ISN30_16980	COG1218	3'(2'),5'-bisphosphate nucleotidase
ISN30_16985	COG0494	nUDIX hydrolase
ISN30_16995	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISN30_17005	COG0837	glucose binding
ISN30_17020	COG3858	chitin binding
ISN30_17020	COG1388	LysM domain
ISN30_17025	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ISN30_17035	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN30_17065	COG3537	Alpha-1,2-mannosidase
ISN30_17170	COG5297	Belongs to the glycosyl hydrolase family 6
ISN30_17175	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISN30_17195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN30_17200	COG1295	ribonuclease BN
ISN30_17235	COG1404	Belongs to the peptidase S8 family
ISN30_17240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISN30_17280	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISN30_17305	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN30_17305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN30_17390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN30_17390	COG4651	solute:proton antiporter activity
ISN30_17400	COG4772	TonB-dependent receptor
ISN30_17410	COG4264	IucA IucC family
ISN30_17415	COG2814	Major facilitator Superfamily
ISN30_17420	COG4264	IucA IucC family
ISN30_17425	COG0019	diaminopimelate decarboxylase activity
ISN30_17460	COG0542	response to heat
ISN30_17510	COG3387	PFAM Glycoside hydrolase 15-related
ISN30_17535	COG0564	pseudouridine synthase activity
ISN30_17540	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN30_17550	COG1125	glycine betaine transport
ISN30_17555	COG1174	glycine betaine transport
ISN30_17570	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISN30_17580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISN30_17580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN30_17625	COG3657	addiction module killer protein
ISN30_17630	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISN30_17655	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ISN30_17670	COG0745	RESPONSE REGULATOR receiver
ISN30_17680	COG0189	ligase activity
ISN30_17690	COG3511	phospholipase C
ISN30_17715	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN30_17730	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN30_17740	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ISN30_17745	COG0174	glutamine synthetase
ISN30_17765	COG2022	thiamine diphosphate biosynthetic process
ISN30_17775	COG3273	potassium ion transport
ISN30_17775	COG0471	metal ion transport
ISN30_17790	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN30_17810	COG1609	Transcriptional regulator
ISN30_17820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN30_17850	COG0840	transmembrane signaling receptor activity
ISN30_17855	COG0529	Catalyzes the synthesis of activated sulfate
ISN30_17855	COG2895	sulfate adenylyltransferase (ATP) activity
ISN30_17860	COG0175	sulfate reduction
ISN30_17865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN30_17870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN30_17875	COG0175	sulfate reduction
ISN30_17905	COG1393	Belongs to the ArsC family
ISN30_17910	COG2205	protein histidine kinase activity
ISN30_17910	COG0784	Response regulator, receiver
ISN30_17910	COG2198	Histidine kinase
ISN30_17940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN30_17980	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ISN30_17985	COG3588	fructose-bisphosphate aldolase
ISN30_17990	COG0469	pyruvate kinase activity
ISN30_18035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISN30_18040	COG3047	cAMP biosynthetic process
ISN30_18060	COG0640	Transcriptional regulator
ISN30_18070	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISN30_18075	COG4149	molybdate abc transporter
ISN30_18080	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ISN30_18105	COG1376	ErfK ybiS ycfS ynhG family protein
ISN30_18110	COG0739	heme binding
ISN30_18145	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISN30_18150	COG1301	dicarboxylic acid transport
ISN30_18180	COG0714	Associated with various cellular activities
ISN30_18210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISN30_18225	COG0372	Belongs to the citrate synthase family
ISN30_18230	COG0254	rRNA binding
ISN30_18245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISN30_18260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN30_18265	COG1758	RNA polymerase activity
ISN30_18270	COG0194	GDP metabolic process
ISN30_18275	COG1561	YicC-like family, N-terminal region
ISN30_18280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ISN30_18285	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISN30_18290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISN30_18310	COG0006	proline dipeptidase activity
ISN30_18315	COG0006	proline dipeptidase activity
ISN30_18320	COG3079	Belongs to the UPF0149 family
ISN30_18345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISN30_18355	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ISN30_18370	COG1773	rubredoxin
ISN30_18385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISN30_18395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN30_18405	COG1940	carbohydrate kinase activity
ISN30_18420	COG0671	phosphoesterase, PA-phosphatase related
ISN30_18430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISN30_18450	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ISN30_18460	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISN30_18485	COG0840	transmembrane signaling receptor activity
ISN30_18490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISN30_18510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISN30_18520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ISN30_18530	COG0066	3-isopropylmalate dehydratase activity
ISN30_18535	COG0473	3-isopropylmalate dehydrogenase activity
ISN30_18540	COG3706	GGDEF domain
ISN30_18550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ISN30_18555	COG1538	Outer membrane efflux protein
ISN30_18560	COG1519	Transferase
ISN30_18565	COG1560	Kdo2-lipid A biosynthetic process
ISN30_18635	COG0281	malic enzyme
ISN30_18635	COG0280	phosphate acetyltransferase
ISN30_18640	COG1301	dicarboxylic acid transport
ISN30_18650	COG4191	Histidine kinase
ISN30_18670	COG0642	Histidine kinase
ISN30_18685	COG2851	Citrate transporter
ISN30_18690	COG1028	Short-chain dehydrogenase reductase Sdr
ISN30_18700	COG2211	Major facilitator Superfamily
ISN30_18725	COG1162	GTPase activity
ISN30_18755	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN30_18775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN30_18825	COG3791	Glutathione-dependent formaldehyde-activating
ISN30_18830	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN30_18845	COG2205	protein histidine kinase activity
ISN30_18870	COG2207	Transcriptional regulator
ISN30_18895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN30_18920	COG0617	tRNA 3'-terminal CCA addition
ISN30_18930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISN30_18935	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN30_18940	COG1609	Transcriptional regulator
ISN30_18945	COG0738	Major facilitator superfamily
ISN30_18950	COG2188	Transcriptional regulator
ISN30_18965	COG3250	beta-galactosidase activity
ISN30_18975	COG4305	rare lipoprotein A
ISN30_18990	COG1028	Short-chain dehydrogenase reductase Sdr
ISN30_18995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISN30_19005	COG4191	Histidine kinase
ISN30_19010	COG0784	Response regulator, receiver
ISN30_19015	COG2205	protein histidine kinase activity
ISN30_19015	COG2202	Pas domain
ISN30_19025	COG2823	Periplasmic or secreted lipoprotein
ISN30_19030	COG0673	inositol 2-dehydrogenase activity
ISN30_19035	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ISN30_19045	COG1090	epimerase
ISN30_19065	COG1056	cytidyltransferase-related domain
ISN30_19065	COG1051	belongs to the nudix hydrolase family
ISN30_19100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ISN30_19105	COG0321	lipoyl(octanoyl) transferase activity
ISN30_19175	COG1686	Belongs to the peptidase S11 family
ISN30_19185	COG2951	lytic endotransglycosylase activity
ISN30_19200	COG0772	Belongs to the SEDS family
ISN30_19205	COG0768	penicillin binding
ISN30_19215	COG1792	Involved in formation and maintenance of cell shape
ISN30_19220	COG1077	Cell shape determining protein MreB Mrl
ISN30_19225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN30_19230	COG3284	Transcriptional regulator
ISN30_19240	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN30_19250	COG2010	Cytochrome c
ISN30_19275	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN30_19275	COG0596	Alpha beta hydrolase
ISN30_19280	COG0308	aminopeptidase N
ISN30_19285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN30_19295	COG2226	methyltransferase
ISN30_19340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISN30_19350	COG2832	Protein of unknown function (DUF454)
ISN30_19360	COG0436	Aminotransferase
ISN30_19365	COG1505	serine-type exopeptidase activity
ISN30_19380	COG1733	regulation of RNA biosynthetic process
ISN30_19395	COG0181	hydroxymethylbilane synthase activity
ISN30_19420	COG0745	RESPONSE REGULATOR receiver
ISN30_19440	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ISN30_19445	COG1640	4-alpha-glucanotransferase
ISN30_19470	COG0243	molybdopterin cofactor binding
ISN30_19475	COG2146	nitrite reductase [NAD(P)H] activity
ISN30_19480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN30_19485	COG2223	nitrite transmembrane transporter activity
ISN30_19490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISN30_19490	COG1116	anion transmembrane transporter activity
ISN30_19500	COG1648	precorrin-2 dehydrogenase activity
ISN30_19500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ISN30_19525	COG4191	Histidine kinase
ISN30_19530	COG0028	Belongs to the TPP enzyme family
ISN30_19545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISN30_19560	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN30_19570	COG1028	Short-chain dehydrogenase reductase Sdr
ISN30_19575	COG3685	Protein conserved in bacteria
ISN30_19580	COG3685	Protein conserved in bacteria
ISN30_19585	COG3546	catalase activity
ISN30_19605	COG0840	transmembrane signaling receptor activity
ISN30_19645	COG1309	transcriptional regulator